#=GF ID Nrf1_activ_bdg
#=GF AC PF10492.14
#=GF DE Nrf1 activator activation site binding domain
#=GF AU Buljan M;0000-0001-8101-8197
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE TreeFam_TF105308
#=GF GA 20.00 20.00;
#=GF TC 20.50 21.90;
#=GF NC 19.90 19.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 8 -E 1000 -Z 90746521 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 10656923
#=GF RT Coding sequence, chromosomal localization, and expression
#=GF RT pattern of Nrf1: the mouse homolog of Drosophila erect wing.
#=GF RA Schaefer L, Engman H, Miller JB;
#=GF RL Mamm Genome. 2000;11:104-110.
#=GF RN [2]
#=GF RM 11069771
#=GF RT Dynein light chain interacts with NRF-1 and EWG, structurally
#=GF RT and functionally related transcription factors from humans and
#=GF RT drosophila.
#=GF RA Herzig RP, Andersson U, Scarpulla RC;
#=GF RL J Cell Sci. 2000;113:4263-4273.
#=GF RN [3]
#=GF RM 11278998
#=GF RT Conserved regions of the Drosophila erect wing protein
#=GF RT contribute both positively and negatively to transcriptional
#=GF RT activity.
#=GF RA Fazio IK, Bolger TA, Gill G;
#=GF RL J Biol Chem. 2001;276:18710-18716.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC In Drosophila, the erect wing (ewg) protein is required for
#=GF CC proper development of the central nervous system and the
#=GF CC indirect flight muscles. The fly ewg gene encodes a novel
#=GF CC DNA-binding domain that is also found in four genes previously
#=GF CC identified in sea urchin, chicken, zebrafish, and human [1].
#=GF CC Nuclear respiratory factor-1 is a transcriptional activator that
#=GF CC has been implicated in the nuclear control of respiratory chain
#=GF CC expression in vertebrates. The first 26 amino acids of nuclear
#=GF CC respiratory factor-1 are required for the binding of dynein
#=GF CC light chain. The interaction with dynein light chain is observed
#=GF CC for both ewg and Nrf-1, transcription factors that are
#=GF CC structurally and functionally similar between humans and
#=GF CC Drosophila [2]. The highest level of expression of both ewg and
#=GF CC Nrf-1 was found in the central nervous system, somites, first
#=GF CC branchial arch, optic vesicle, and otic vesicle. In the mouse
#=GF CC Nrf-1 protein, Swiss:Q8C4C0, there is an activation domain at
#=GF CC 303-469, the most conserved part of which is this domain
#=GF CC 446-469. Ewg is a site-specific transcriptional activator, and
#=GF CC evolutionarily conserved regions of ewg contribute both
#=GF CC positively and negatively to transcriptional activity [3]. The
#=GF CC family Nrf1_DNA-bind is associated with this domain towards the
#=GF CC N-terminal, as is the N terminal of the activation domain.
#=GF SQ 11
#=GS A7SRK9_NEMVE/392-471 AC A7SRK9.1
#=GS A0A6P8HI43_ACTTE/383-465 AC A0A6P8HI43.1
#=GS A0A3M6TII8_POCDA/382-464 AC A0A3M6TII8.1
#=GS A0A913XUT9_EXADI/430-511 AC A0A913XUT9.1
#=GS A0A7D9IZY6_PARCT/375-456 AC A0A7D9IZY6.1
#=GS A0A9W9YAE1_9CNID/397-479 AC A0A9W9YAE1.1
#=GS A0AAD9Q6P3_ACRCE/390-473 AC A0AAD9Q6P3.1
#=GS F1VVM7_9BURK/59-128 AC F1VVM7.1
#=GS A0A7M7HK67_STRPU/394-454 AC A0A7M7HK67.1
#=GS A0A2B4RYH6_STYPI/393-475 AC A0A2B4RYH6.1
#=GS P3A2_STRPU/390-450 AC Q04073.1
A7SRK9_NEMVE/392-471 ....SQMVTIPVQAAASLMQIQGHTMLTNSQAQFI.T..S...VPQVAMAPHTI....V...TVTSGGHTH.HHHIVD.TNCDG.VPVATQAV--EVVTLDN....
A0A6P8HI43_ACTTE/383-465 vqdg--MVTIPVQAAVSLMQFQGQ-MLSSGQPHYV.TtsS...VPQVAMAPHTI....I...TVTSSNHSD.SHNNMV.DSVEG.VPVATQAV--EVVTLEN....
A0A3M6TII8_POCDA/382-464 ....SNMVTIPVQAAASLMQIQTHHLPASTHSQYI.S.aS...VPQVAMAPHSI....IqtvTTSTMGHEV.HTQIVD.T-CEG.VPVATQAV--EVVTLEN....
A0A913XUT9_EXADI/430-511 ..dg--MVSIPVQAAASLMQIQGH-MLNNNQTHYI.T..SttgVPQVAMAPHTI....I...TVTSSNQAEsHTHIVD.S-TEG.VPVATQAV--EVVTLEN....
A0A7D9IZY6_PARCT/375-456 ...s-NLVTIPVHAAAAMMQIQNG-QITNSQTQYIaT..S...IPQVAMAPHSN....L..hTVNSPQSI-.QTQLVDsTGAENpVPGASQAV--EVVTY--st..
A0A9W9YAE1_9CNID/397-479 ....SNMVTIPLQAAASLMQIQTHHLPVSTHAQYMsA..S...VPQVAMAPHSI....IqtvTTSAMGHEV.HTHIVD.T-CEG.VPVATQAV--EVVTLEN....
A0AAD9Q6P3_ACRCE/390-473 ....SNMVTIPVQAAASLMQIQTHHLPVSSHSQYMsA..S...VPQVAMAPHSMpqtaT...TSAVGGHDD.NTHMVV.T-CEG.VPVATQAV--EVVTLEN....
F1VVM7_9BURK/59-128 ..lr---IATPVAAAAEL-----HTMSMTGNVMKM.R..E...VPEIAIAANTT....L...TMASGDGY-.--HVML.TGLKQ.PLIAGQPVPL-------sltf
A0A7M7HK67_STRPU/394-454 ....AQGIVIPA----SVYQ----TVVA-GDGQ--.-..P...I-QIANVN---....I...AQQSGGGT-.----TM.AAIKN.AVMQSQPIPSQVATLVV....
A0A2B4RYH6_STYPI/393-475 ....SNMVTIPVQAAASLMQIQTHHLPASTHSQYI.S.aS...VPQVAMAPHSI....IqtvTTSTMGHEV.HTQIVD.T-CEG.VPVATQAV--EVVTLEN....
P3A2_STRPU/390-450 ....AQGIVIPA----SVYQ----TVVA-GDGQ--.-..P...I-QIANVN---....I...AQQSGGGT-.----TM.AAIKN.AVMQSQPIPSQVATLVV....
#=GC seq_cons ....upMVTIPVQAAASLMQIQsHphsssupuQYh.s..S...VPQVAMAPHoh....I...TssSuGpp..ppplVs.T.sEG.VPVATQAV..EVVTL-N....
//
