GenomeNet

Database: Pfam
Entry: Nup214_FG
LinkDB: Nup214_FG
Original site: Nup214_FG 
#=GF ID   Nup214_FG
#=GF AC   PF18617.3
#=GF DE   Nucleoporin Nup214 phenylalanine-glycine (FG) domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF08745
#=GF GA   26.10 26.10;
#=GF TC   26.90 40.60;
#=GF NC   25.50 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   26489467
#=GF RT   Structural and Functional Characterization of CRM1-Nup214
#=GF RT   Interactions Reveals Multiple FG-Binding Sites Involved in
#=GF RT   Nuclear Export.
#=GF RA   Port SA, Monecke T, Dickmanns A, Spillner C, Hofele R, Urlaub H,
#=GF RA   Ficner R, Kehlenbach RH;
#=GF RL   Cell Rep. 2015;13:690-702.
#=GF DR   INTERPRO; IPR041553;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   CRM1 is the major nuclear export receptor. During translocation
#=GF CC   through the nuclear pore, transport complexes transiently
#=GF CC   interact with phenylalanine-glycine (FG) repeats of multiple
#=GF CC   nucleoporins. On the cytoplasmic side of the nuclear pore, CRM1
#=GF CC   tightly interacts with the nucleoporin Nup214. Nup214 binds to
#=GF CC   N- and C-terminal regions of CRM1, thereby clamping CRM1 in a
#=GF CC   closed conformation and stabilizing the export complex. This
#=GF CC   entry represents an FG repeat region within the C terminus of
#=GF CC   Nup214 which is required for its interaction with CRM1 [1].
#=GF SQ   206
#=GS A0A673ZQN4_SALTR/1833-1900  AC A0A673ZQN4.1
#=GS A0A4W3J9Q0_CALMI/1471-1533  AC A0A4W3J9Q0.1
#=GS A0A553Q0X2_9TELE/1070-1130  AC A0A553Q0X2.1
#=GS D4ACK1_RAT/1616-1677        AC D4ACK1.2
#=GS A0A455BX00_PHYMC/1567-1629  AC A0A455BX00.1
#=GS A0A494C1F2_HUMAN/1903-1965  AC A0A494C1F2.1
#=GS A0A673A4Q5_9TELE/1409-1472  AC A0A673A4Q5.1
#=GS A0A2Y9HCH1_NEOSC/1217-1279  AC A0A2Y9HCH1.1
#=GS A0A2R9B1P9_PANPA/1915-1977  AC A0A2R9B1P9.1
#=GS F6PN31_MONDO/1826-1888      AC F6PN31.3
#=GS A0A226NPQ8_CALSU/1771-1832  AC A0A226NPQ8.1
#=GS S4RW40_PETMA/74-142         AC S4RW40.1
#=GS A0A1S3KZR7_SALSA/1830-1897  AC A0A1S3KZR7.1
#=GS A0A5C6NGP7_9TELE/1804-1866  AC A0A5C6NGP7.1
#=GS H0Z389_TAEGU/1910-1971      AC H0Z389.2
#=GS K7FJM7_PELSI/1913-1974      AC K7FJM7.1
#=GS A0A091IH84_CALAN/1444-1505  AC A0A091IH84.1
#=GS A0A2U9CFI8_SCOMX/1814-1877  AC A0A2U9CFI8.1
#=GS A0A2I3H3T4_NOMLE/740-802    AC A0A2I3H3T4.1
#=GS A0A091UMX4_PHALP/1460-1521  AC A0A091UMX4.1
#=GS A0A3Q2LCB0_HORSE/745-807    AC A0A3Q2LCB0.2
#=GS A0A5N5JVU4_PANHP/506-570    AC A0A5N5JVU4.1
#=GS A0A5F8GD67_MONDO/1765-1827  AC A0A5F8GD67.1
#=GS A0A671ESY8_RHIFE/1913-1975  AC A0A671ESY8.1
#=GS A0A670KF62_PODMU/1518-1580  AC A0A670KF62.1
#=GS A0A2I4BAT3_9TELE/1795-1858  AC A0A2I4BAT3.1
#=GS A0A151MFL4_ALLMI/1384-1446  AC A0A151MFL4.1
#=GS A0A091FW91_CORBR/1447-1508  AC A0A091FW91.1
#=GS A0A218V6F0_9PASE/1910-1971  AC A0A218V6F0.1
#=GS A0A2I4BAS3_9TELE/1795-1857  AC A0A2I4BAS3.1
#=GS A0A6Q2ZNR6_ESOLU/1610-1677  AC A0A6Q2ZNR6.1
#=GS G1MD28_AILME/1910-1972      AC G1MD28.1
#=GS A0A060WH25_ONCMY/1818-1885  AC A0A060WH25.1
#=GS A0A2K5ZJX9_MANLE/1899-1961  AC A0A2K5ZJX9.1
#=GS A0A060XAW2_ONCMY/311-378    AC A0A060XAW2.1
#=GS A0A4W5KMY0_9TELE/1829-1896  AC A0A4W5KMY0.1
#=GS A0A3P8WL25_CYNSE/1857-1919  AC A0A3P8WL25.1
#=GS A0A2K5IGI8_COLAP/1900-1962  AC A0A2K5IGI8.1
#=GS A0A3B5QG13_XIPMA/1806-1870  AC A0A3B5QG13.1
#=GS A0A0N8K2H4_SCLFO/9-71       AC A0A0N8K2H4.1
#=GS A0A3Q3M298_9TELE/1789-1851  AC A0A3Q3M298.1
#=GS U3J119_ANAPP/1599-1661      AC U3J119.2
#=GS G3RLU6_GORGO/1914-1976      AC G3RLU6.2
#=GS G3PWA7_GASAC/1797-1859      AC G3PWA7.1
#=GS L5MGH6_MYODS/70-132         AC L5MGH6.1
#=GS A0A1S3LC88_SALSA/1838-1906  AC A0A1S3LC88.1
#=GS A0A401T8V7_CHIPU/1-61       AC A0A401T8V7.1
#=GS A0A0A0MSW3_HUMAN/1344-1406  AC A0A0A0MSW3.1
#=GS G5AT56_HETGA/1914-1976      AC G5AT56.1
#=GS A0A6Q2Z6F2_ESOLU/1824-1891  AC A0A6Q2Z6F2.1
#=GS A0A452HNG0_9SAUR/1812-1873  AC A0A452HNG0.1
#=GS A0A671VCC1_SPAAU/1541-1602  AC A0A671VCC1.1
#=GS A0A1S3WKH3_ERIEU/1905-1967  AC A0A1S3WKH3.1
#=GS A0A2U3VD37_ODORO/1909-1971  AC A0A2U3VD37.1
#=GS A0A672GAN1_SALFA/1565-1626  AC A0A672GAN1.1
#=GS A0A091PJ35_APAVI/1475-1537  AC A0A091PJ35.1
#=GS A0A5F8GS57_MONDO/1724-1786  AC A0A5F8GS57.1
#=GS A0A5F5XSF1_FELCA/750-812    AC A0A5F5XSF1.1
#=GS A0A4W3J6U4_CALMI/978-1040   AC A0A4W3J6U4.1
#=GS A0A494C0Y1_HUMAN/263-325    AC A0A494C0Y1.1
#=GS A0A151MG00_ALLMI/1384-1445  AC A0A151MG00.1
#=GS A2ATN3_MOUSE/406-468        AC A2ATN3.1
#=GS F1PFL8_CANLF/1913-1975      AC F1PFL8.3
#=GS A0A3Q3M6R7_9TELE/1789-1851  AC A0A3Q3M6R7.1
#=GS A0A4D9E0M5_9SAUR/1930-1991  AC A0A4D9E0M5.1
#=GS K7FJN4_PELSI/1851-1912      AC K7FJN4.1
#=GS A0A5J5MIE1_MUNRE/706-768    AC A0A5J5MIE1.1
#=GS A0A2Y9F5G4_PHYMC/1929-1991  AC A0A2Y9F5G4.1
#=GS A0A3Q7WYE3_URSAR/1861-1923  AC A0A3Q7WYE3.1
#=GS A0A452G6L3_CAPHI/1875-1937  AC A0A452G6L3.1
#=GS A0A4W5KQX8_9TELE/1829-1896  AC A0A4W5KQX8.1
#=GS A0A5J5CQQ1_9PERO/1795-1857  AC A0A5J5CQQ1.1
#=GS A0A672G8W3_SALFA/1821-1882  AC A0A672G8W3.1
#=GS A0A2R9B875_PANPA/1915-1977  AC A0A2R9B875.1
#=GS B7ZAV2_HUMAN/741-803        AC B7ZAV2.1
#=GS A0A401P002_SCYTO/973-1036   AC A0A401P002.1
#=GS A0A673ZT71_SALTR/1529-1596  AC A0A673ZT71.1
#=GS A0A674MQL7_TAKRU/1562-1624  AC A0A674MQL7.1
#=GS G3SME4_LOXAF/1364-1426      AC G3SME4.1
#=GS G3WXU8_SARHA/1946-2008      AC G3WXU8.1
#=GS A0A670KBZ8_PODMU/1639-1701  AC A0A670KBZ8.1
#=GS W5MGY2_LEPOC/1882-1944      AC W5MGY2.1
#=GS A0A6Q2XMS2_ESOLU/1643-1710  AC A0A6Q2XMS2.1
#=GS M4AA87_XIPMA/1807-1871      AC M4AA87.1
#=GS A0A091LZ03_CARIC/1470-1531  AC A0A091LZ03.1
#=GS A0A099Z5J8_TINGU/1470-1531  AC A0A099Z5J8.1
#=GS H0Y837_HUMAN/768-830        AC H0Y837.1
#=GS H2QY24_PANTR/1915-1977      AC H2QY24.2
#=GS H9GW15_ANOCA/260-333        AC H9GW15.1
#=GS A0A3Q3SAY0_9TELE/1809-1871  AC A0A3Q3SAY0.1
#=GS A0A6I8PXG4_XENTR/1105-1164  AC A0A6I8PXG4.1
#=GS A0A3P9PRZ0_POERE/1792-1849  AC A0A3P9PRZ0.1
#=GS A0A6G0I0M1_LARCR/728-790    AC A0A6G0I0M1.1
#=GS A0A3Q2HL89_HORSE/1347-1409  AC A0A3Q2HL89.2
#=GS M3YMF4_MUSPF/1855-1917      AC M3YMF4.1
#=GS A0A4U5VA42_COLLU/1811-1873  AC A0A4U5VA42.1
#=GS G1P3G0_MYOLU/1891-1953      AC G1P3G0.1
#=GS A0A553Q105_9TELE/1121-1181  AC A0A553Q105.1
#=GS NU214_HUMAN/1915-1977       AC P35658.2
#=GS NU214_HUMAN/1915-1977       DR PDB; 5DIS D; 1916-1951;
#=GS A0A2R9B3B8_PANPA/741-803    AC A0A2R9B3B8.1
#=GS H2LQE1_ORYLA/1792-1855      AC H2LQE1.2
#=GS A0A6I8NR43_ORNAN/1772-1833  AC A0A6I8NR43.1
#=GS A0A437CUZ5_ORYJA/1785-1849  AC A0A437CUZ5.1
#=GS G3WXU7_SARHA/1949-2011      AC G3WXU7.1
#=GS A0A673VU17_SURSU/1905-1967  AC A0A673VU17.1
#=GS A0A673ZQ32_SALTR/1411-1478  AC A0A673ZQ32.1
#=GS A0A6Q2Z3A6_ESOLU/1822-1889  AC A0A6Q2Z3A6.1
#=GS A0A1S3FK94_DIPOR/1821-1883  AC A0A1S3FK94.1
#=GS A0A674PAR7_TAKRU/1596-1659  AC A0A674PAR7.1
#=GS A0A3L8SDM9_CHLGU/1947-2008  AC A0A3L8SDM9.1
#=GS G1N1Z5_MELGA/1898-1959      AC G1N1Z5.2
#=GS A0A670KDR2_PODMU/1633-1695  AC A0A670KDR2.1
#=GS A0A2I0TRH3_LIMLA/1011-1072  AC A0A2I0TRH3.1
#=GS A0A3P9A559_ESOLU/1823-1890  AC A0A3P9A559.2
#=GS A0A452HND8_9SAUR/1877-1938  AC A0A452HND8.1
#=GS A0A485MGY6_LYNPA/1266-1328  AC A0A485MGY6.1
#=GS A0A3P8TGL7_AMPPE/1803-1865  AC A0A3P8TGL7.1
#=GS H2T2B6_TAKRU/1804-1866      AC H2T2B6.3
#=GS F7EGH7_ORNAN/1915-1976      AC F7EGH7.2
#=GS A0A6A1QGV5_BALPH/50-99      AC A0A6A1QGV5.1
#=GS A0A096LWA4_POEFO/1783-1847  AC A0A096LWA4.1
#=GS A0A0A0AWW1_CHAVO/1475-1536  AC A0A0A0AWW1.1
#=GS A0A4X2L4D1_VOMUR/1935-1997  AC A0A4X2L4D1.1
#=GS A0A673A4L4_9TELE/1386-1449  AC A0A673A4L4.1
#=GS H2LQD9_ORYLA/1792-1855      AC H2LQD9.2
#=GS A0A671VDS7_SPAAU/1528-1589  AC A0A671VDS7.1
#=GS A0A673WML7_SALTR/1839-1907  AC A0A673WML7.1
#=GS H2PTQ3_PONAB/1872-1934      AC H2PTQ3.1
#=GS A0A2I4BAT4_9TELE/1794-1857  AC A0A2I4BAT4.1
#=GS A0A2I3RKQ3_PANTR/741-803    AC A0A2I3RKQ3.1
#=GS A0A4W5R372_9TELE/1827-1894  AC A0A4W5R372.1
#=GS A0A1S3LCJ1_SALSA/1838-1906  AC A0A1S3LCJ1.1
#=GS A0A6A5EFH8_PERFL/1801-1863  AC A0A6A5EFH8.1
#=GS A0A673WM85_SALTR/1839-1907  AC A0A673WM85.1
#=GS A0A3Q1BCI7_AMPOC/1789-1851  AC A0A3Q1BCI7.1
#=GS H3BBA7_LATCH/1917-1970      AC H3BBA7.1
#=GS A0A226P137_COLVI/1714-1775  AC A0A226P137.1
#=GS A0A384CRJ1_URSMA/1879-1941  AC A0A384CRJ1.1
#=GS A0A1S3KZN5_SALSA/1831-1898  AC A0A1S3KZN5.1
#=GS L8Y8B9_TUPCH/432-494        AC L8Y8B9.1
#=GS A0A1V4J6B8_PATFA/1855-1916  AC A0A1V4J6B8.1
#=GS A0A553Q0X4_9TELE/1055-1115  AC A0A553Q0X4.1
#=GS S9Y7D1_CAMFR/1526-1588      AC S9Y7D1.1
#=GS A0A452QWQ0_URSAM/1839-1901  AC A0A452QWQ0.1
#=GS A0A1V4J695_PATFA/1854-1915  AC A0A1V4J695.1
#=GS A0A093JBE0_STRCA/1471-1532  AC A0A093JBE0.1
#=GS A0A2Y9HB49_NEOSC/1911-1973  AC A0A2Y9HB49.1
#=GS A0A2K6PZ22_RHIRO/1900-1962  AC A0A2K6PZ22.1
#=GS A0A665WPM8_ECHNA/1644-1706  AC A0A665WPM8.1
#=GS A0A1S3LDL5_SALSA/1838-1906  AC A0A1S3LDL5.1
#=GS A0A5E4CX98_MARMO/1926-1988  AC A0A5E4CX98.1
#=GS I3KCK6_ORENI/1501-1563      AC I3KCK6.2
#=GS A0A452QWS4_URSAM/1550-1612  AC A0A452QWS4.1
#=GS A0A6Q2WZW2_ESOLU/1823-1890  AC A0A6Q2WZW2.1
#=GS A0A1S3KZL8_SALSA/1830-1898  AC A0A1S3KZL8.1
#=GS A0A452HNG4_9SAUR/1931-1992  AC A0A452HNG4.1
#=GS A0A3P8WRF5_CYNSE/1877-1939  AC A0A3P8WRF5.1
#=GS A0A1S3L009_SALSA/1831-1898  AC A0A1S3L009.1
#=GS A0A3Q7X6Q0_URSAR/1912-1974  AC A0A3Q7X6Q0.1
#=GS A0A087XYI8_POEFO/1511-1575  AC A0A087XYI8.2
#=GS A0A4W5R3U4_9TELE/1827-1894  AC A0A4W5R3U4.1
#=GS A0A493TE90_ANAPP/1616-1677  AC A0A493TE90.1
#=GS A0A315VTT8_GAMAF/1802-1865  AC A0A315VTT8.1
#=GS A0A3N0YF24_ANAGA/1736-1798  AC A0A3N0YF24.1
#=GS A0A5F5Y682_FELCA/1346-1408  AC A0A5F5Y682.1
#=GS A0A3M0JF95_HIRRU/1810-1871  AC A0A3M0JF95.1
#=GS A0A2I4BAP3_9TELE/1794-1857  AC A0A2I4BAP3.1
#=GS A0A384B544_BALAS/1768-1830  AC A0A384B544.1
#=GS A0A3Q0GRC7_ALLSI/1640-1701  AC A0A3Q0GRC7.1
#=GS A0A5F8HKG1_MONDO/1688-1750  AC A0A5F8HKG1.1
#=GS H3C4U1_TETNG/1638-1700      AC H3C4U1.1
#=GS A0A3Q7SR70_VULVU/1920-1982  AC A0A3Q7SR70.1
#=GS A0A3Q3AWE4_KRYMA/1793-1855  AC A0A3Q3AWE4.1
#=GS A0A3Q1FKP4_9TELE/1789-1851  AC A0A3Q1FKP4.1
#=GS A0A452QWN1_URSAM/1853-1915  AC A0A452QWN1.1
#=GS H3CL16_TETNG/1627-1689      AC H3CL16.1
#=GS A0A5E4CXD6_MARMO/1318-1380  AC A0A5E4CXD6.1
#=GS A0A2Y9F6D2_PHYMC/1928-1990  AC A0A2Y9F6D2.1
#=GS A0A4W5KMH5_9TELE/1829-1896  AC A0A4W5KMH5.1
#=GS A0A091DLG3_FUKDA/1907-1969  AC A0A091DLG3.1
#=GS A0A3Q7XSV7_URSAR/1911-1973  AC A0A3Q7XSV7.1
#=GS A0A3P9CV31_9CICH/1833-1895  AC A0A3P9CV31.1
#=GS A0A672UXL3_STRHB/1795-1856  AC A0A672UXL3.1
#=GS A0A3Q1J086_ANATE/1835-1897  AC A0A3Q1J086.1
#=GS U3JFF9_FICAL/1874-1935      AC U3JFF9.1
#=GS H3C706_TETNG/1285-1347      AC H3C706.1
#=GS R0LZR9_ANAPL/1865-1926      AC R0LZR9.1
#=GS A0A2Y9F5S3_PHYMC/1927-1989  AC A0A2Y9F5S3.1
#=GS A0A672G8W5_SALFA/1821-1882  AC A0A672G8W5.1
#=GS A0A0Q3X9G1_AMAAE/1727-1788  AC A0A0Q3X9G1.1
#=GS A0A6Q2XSL0_ESOLU/1823-1890  AC A0A6Q2XSL0.1
#=GS A0A452QWH3_URSAM/1905-1967  AC A0A452QWH3.1
#=GS A0A671VEI9_SPAAU/1537-1599  AC A0A671VEI9.1
#=GS A0A1S3LDJ8_SALSA/1838-1906  AC A0A1S3LDJ8.1
#=GS A0A452QWL7_URSAM/1876-1938  AC A0A452QWL7.1
#=GS A0A091P954_HALAL/1453-1514  AC A0A091P954.1
#=GS M7BGC9_CHEMY/1855-1916      AC M7BGC9.1
#=GS A0A2K6LZF4_RHIBE/707-769    AC A0A2K6LZF4.1
#=GS A0A4W3JLK3_CALMI/1491-1553  AC A0A4W3JLK3.1
#=GS A0A3Q4GMN7_NEOBR/1109-1172  AC A0A3Q4GMN7.1
#=GS A0A2I4BAN7_9TELE/1794-1856  AC A0A2I4BAN7.1
#=GS A0A665WPZ5_ECHNA/1512-1574  AC A0A665WPZ5.1
#=GS A0A665WNW7_ECHNA/1655-1717  AC A0A665WNW7.1
#=GS A0A2I3SSV6_PANTR/1915-1977  AC A0A2I3SSV6.1
#=GS A0A673A406_9TELE/1449-1512  AC A0A673A406.1
#=GS A0A6I8NCW8_ORNAN/1826-1887  AC A0A6I8NCW8.1
A0A673ZQN4_SALTR/1833-1900             ...q-TGGTTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPTKqTGGFGSAPVFG..
A0A4W3J9Q0_CALMI/1471-1533             ..dh---SPNLFGNSGAKTF...GFG.N.S.S..........F..GtEQKS.....SG...LFSAGS-SVASQGFGSFASPTKpAGGFGAAPVFG..
A0A553Q0X2_9TELE/1070-1130             ..nt--APASLFGSSGAKSF...SFA.G.S.S..........F..G.DQKQahglnSG...SFSSGAGSVAAQGFGSFNTPSK.SVG--------i.
D4ACK1_RAT/1616-1677                   ...t-PNTSNLFGNSGAKTF..gGFG.-.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A455BX00_PHYMC/1567-1629             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.DQKP.....AG...TFSSGGGSVASQGFG-FSTPSK.TGGFGAAPVFG..
A0A494C1F2_HUMAN/1903-1965             ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A673A4Q5_9TELE/1409-1472             ..pi--GANNLFGNSGAKAF...GFG.QqS.S..........F..G.EQKP.....TG...TFSTGGGSVASQGFGSFSTPSK.PGGFGSAPVFG..
A0A2Y9HCH1_NEOSC/1217-1279             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A2R9B1P9_PANPA/1915-1977             ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
F6PN31_MONDO/1826-1888                 ...t-PNTPNLFGNSGAKTF..gGFS.G.S.S..........F..G.EQKP.....TG...TFSSGGGSVAAQGFG-FSSPTK.TGGFGAAPVFG..
A0A226NPQ8_CALSU/1771-1832             ...s-QNSSNLFGNSGAKAF...GFG.S.S.S..........F..G.DQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
S4RW40_PETMA/74-142                    sssa--DPPSLFGAS-APAFcspTSG.T.G.G..........F..G.EQKP.....AGaggTFS-GGASVAAQGFGAISSPCK.TPGFGGPPAFG..
A0A1S3KZR7_SALSA/1830-1897             ...q-TGGTTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPTKqTGGFGSAPVFG..
A0A5C6NGP7_9TELE/1804-1866             ..pp--AANTLFGNSGAKTF...GFG.Q.S.S..........F..G.EQKA.....SG...TFTAGSGSVASQGFGSYSTPAK.PGGFGSAPVFG..
H0Z389_TAEGU/1910-1971                 ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.AGGFGAAPVFG..
K7FJM7_PELSI/1913-1974                 ...s-QNTSSLFGNNGAKTF...RFG.N.S.S..........Y..G.EQKP.....TG...TFSSGGGTVAAQGFG-FSSPTK.AGGFGAAPVFG..
A0A091IH84_CALAN/1444-1505             ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A2U9CFI8_SCOMX/1814-1877             ...aQTGGNSLFGNSGAKTF...GFG.Q.P.S..........F..G.EQKP.....GG...TFSTGGGSVSSQGFGSFSTPSK.SGAFGTAPVFG..
A0A2I3H3T4_NOMLE/740-802               ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A091UMX4_PHALP/1460-1521             ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.DQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A3Q2LCB0_HORSE/745-807               ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTQNK.TGGFGAAPVFG..
A0A5N5JVU4_PANHP/506-570               .qtn-QTSGNLFGNSGAKAF...GYG.V.S.T..........F..V.EQKP.....SG...TFSAGRGSVAAQGFGSFSTPAK.TGGFGSAPVFG..
A0A5F8GD67_MONDO/1765-1827             ...t-PNTPNLFGNSGAKTF..gGFS.G.S.S..........F..G.EQKP.....TG...TFSSGGGSVAAQGFG-FSSPTK.TGGFGAAPVFG..
A0A671ESY8_RHIFE/1913-1975             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FPVPNK.TGGFGAAPVFG..
A0A670KF62_PODMU/1518-1580             ...t-QNTSSLFGNSGAKTF...GFG.T.TaS..........F..G.EQKP.....MG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A2I4BAT3_9TELE/1795-1858             ....QPGTNNLFGNSGAKAF...GFG.Q.S.A..........F..G.EQKP.....SG...TFTTGAGSVASQGFGSFSTPQKtTGGFGSAPVFG..
A0A151MFL4_ALLMI/1384-1446             ..ts-QNTSSLFGNSGAKTF...GYG.T.S.T..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A091FW91_CORBR/1447-1508             ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.AGGFGAAPVFG..
A0A218V6F0_9PASE/1910-1971             ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.AGGFGAAPVFG..
A0A2I4BAS3_9TELE/1795-1857             ....QPGTNNLFGNSGAKAF...GFG.Q.S.A..........F..G.EQKP.....SG...TFTTGAGSVASQGFGSFSTPQK.TSGFGSAPVFG..
A0A6Q2ZNR6_ESOLU/1610-1677             ..pt--GGTTLFGSSGAKTF...GFG.S.P.As........aFggG.EQKP.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
G1MD28_AILME/1910-1972                 ...t-PNNSNLFGNSGAKTF..gGFT.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTANK.TGGFGAAPVFG..
A0A060WH25_ONCMY/1818-1885             ...q-TGGTTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPTKqTGGFGSAPVFG..
A0A2K5ZJX9_MANLE/1899-1961             ...t-ANTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A060XAW2_ONCMY/311-378               ..qt--GGPTLFGNSGAKTF...GFG.S.P.As........aFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A4W5KMY0_9TELE/1829-1896             ...q-TGGTTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPTKqTGGFGSAPVFG..
A0A3P8WL25_CYNSE/1857-1919             ....QTGTNTLFGNSGAKAF...GFG.Q.S.S..........F..G.EQKP.....SG...TFSTGGVSVASQGFGSFSTPTK.AAGFASAPVFG..
A0A2K5IGI8_COLAP/1900-1962             ...t-ANTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A3B5QG13_XIPMA/1806-1870             ....QSGSNNLFGNSGAKAF...GFG.Q.T.Ss........aF..G.DQKP.....SG...TFSTGGGSVASQGFGSFSSPTK.PGGFGSPPVFG..
A0A0N8K2H4_SCLFO/9-71                  ....HAGSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....AG...TFSAGGGSVAAQGFGSFTSPAK.PGGFGSAPVFG..
A0A3Q3M298_9TELE/1789-1851             ....QTGTSSLFGNSGAKTF...SFG.Q.T.P..........F..G.EQKS.....SG...TFSTGGGSVASQGFGSFSTPTK.SGGFGTAPVFG..
U3J119_ANAPP/1599-1661                 ..as-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
G3RLU6_GORGO/1914-1976                 ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
G3PWA7_GASAC/1797-1859                 ....QTGANTLFGSSSAKTF...GFG.Q.S.S..........F..G.EQKA.....SG...TFSTGAGSVASQGFGSFSSPTK.TGGFGSAPVFG..
L5MGH6_MYODS/70-132                    ...a-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSAGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A1S3LC88_SALSA/1838-1906             .nqt--GGPTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A401T8V7_CHIPU/1-61                  ...a----QSLFGNSGAKTF...GFG.S.A.S..........F..GsDLKT.....PG...SFSAGS-SVAAQGFGNFSTPSKpPGGFGAAPVFG..
A0A0A0MSW3_HUMAN/1344-1406             ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
G5AT56_HETGA/1914-1976                 ...t-PNTSNLFGNSGAKSF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSAPSK.TGGFGAAPVFG..
A0A6Q2Z6F2_ESOLU/1824-1891             ...q-TGGTTLFGSSGAKTF...GFG.S.P.As........aFggG.EQKP.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A452HNG0_9SAUR/1812-1873             ...s-QNTSSLFGNNGAKTF...RFG.N.S.S..........Y..G.EQKP.....TG...TFSSGGGTVAAQGFG-FSSPTK.AGGFGAAPVFG..
A0A671VCC1_SPAAU/1541-1602             ...l--GATSLFGNSGAKTF...GFG.Q.S.S..........F..G.EQKP.....SG...TFSTGGGTVASQGFGSFSSPSK.PGGFGSAPVFG..
A0A1S3WKH3_ERIEU/1905-1967             ...t-PNTSNLFGNSGAKTF..gGFA.T.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A2U3VD37_ODORO/1909-1971             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A672GAN1_SALFA/1565-1626             .ksf---TSVLFGNSGAKPL...GFG.Q.S.S..........F..G.EQKP.....GG...-FSTGGGSVASQGFGSFSTPTK.PGGFGSAPVFG..
A0A091PJ35_APAVI/1475-1537             ..as-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FTSPNK.AGGFGAAPVFG..
A0A5F8GS57_MONDO/1724-1786             ...t-PNTPNLFGNSGAKTF..gGFS.G.S.S..........F..G.EQKP.....TG...TFSSGGGSVAAQGFG-FSSPTK.TGGFGAAPVFG..
A0A5F5XSF1_FELCA/750-812               ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A4W3J6U4_CALMI/978-1040              ..dh---SPNLFGNSGAKTF...GFG.N.S.S..........F..GtEQKS.....SG...LFSAGS-SVASQGFGSFASPTKpAGGFGAAPVFG..
A0A494C0Y1_HUMAN/263-325               ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A151MG00_ALLMI/1384-1445             ...s-QNTSSLFGNSGAKTF...GYG.T.S.T..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A2ATN3_MOUSE/406-468                   ...a-PNTSNLFGNSGAKTF..gGFG.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
F1PFL8_CANLF/1913-1975                 ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A3Q3M6R7_9TELE/1789-1851             ....QTGTSSLFGNSGAKTF...SFG.Q.T.P..........F..G.EQKS.....SG...TFSTGGGSVASQGFGSFSTPTK.SGGFGTAPVFG..
A0A4D9E0M5_9SAUR/1930-1991             ...s-QNTSSLFGNNGAKTF...RFG.N.S.S..........Y..G.EQKP.....TG...TFSSGGGTVAAQGFG-FSSPTK.AGGFGAAPVFG..
K7FJN4_PELSI/1851-1912                 ...s-QNTSSLFGNNGAKTF...RFG.N.S.S..........Y..G.EQKP.....TG...TFSSGGGTVAAQGFG-FSSPTK.AGGFGAAPVFG..
A0A5J5MIE1_MUNRE/706-768               ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.DQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A2Y9F5G4_PHYMC/1929-1991             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.DQKP.....AG...TFSSGGGSVASQGFG-FSTPSK.TGGFGAAPVFG..
A0A3Q7WYE3_URSAR/1861-1923             ...t-PNTSNLFGNSGAKTF..gGFT.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTANK.TGGFGAAPVFG..
A0A452G6L3_CAPHI/1875-1937             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.DQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A4W5KQX8_9TELE/1829-1896             ...q-TGGTTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPTKqTGGFGSAPVFG..
A0A5J5CQQ1_9PERO/1795-1857             ....QTGANTLFGNSSAKTF...GFG.Q.S.S..........F..G.EQKP.....SG...TFSTGAGSVASQGFGSFSSPAK.SGGFGSAPVFG..
A0A672G8W3_SALFA/1821-1882             ....QAGTNSLFGNSGAKPL...GFG.Q.S.S..........F..G.EQKP.....GG...-FSTGGGSVASQGFGSFSTPTK.PGGFGSAPVFG..
A0A2R9B875_PANPA/1915-1977             ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
B7ZAV2_HUMAN/741-803                   ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A401P002_SCYTO/973-1036              ...a-AGAQSLFGNSGAKTF...GFG.S.A.T..........F..GsDLKS.....AG...SFSAGS-SVASQGFGSFTTPTKpPGGFGAAPVFG..
A0A673ZT71_SALTR/1529-1596             .nqt---GTTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPTKqTGGFGSAPVFG..
A0A674MQL7_TAKRU/1562-1624             ..pp--AANTLFGNSGAKTF...GFG.Q.S.S..........F..G.EQKA.....SG...TFTAGSGSVASQGFGSYSTPAK.PGGFGSAPVFG..
G3SME4_LOXAF/1364-1426                 ...t-PNTSNLFGNSGAKTF..gGFT.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.AGGFGAAPVFG..
G3WXU8_SARHA/1946-2008                 ...t-PNTSNLFGNSGAKTF..gGFS.G.S.S..........F..G.DQKP.....AG...TFSSGGGSVAAQGFG-FSSPTK.AGGFGAAPVFG..
A0A670KBZ8_PODMU/1639-1701             ...t-QNTSSLFGNSGAKTF...GFG.T.TaS..........F..G.EQKP.....MG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
W5MGY2_LEPOC/1882-1944                 ....QAGTSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....SG...TFSTGGGTVAAQGFGSFSTPAK.TGGFGGTPVFG..
A0A6Q2XMS2_ESOLU/1643-1710             .nqt---GTTLFGSSGAKTF...GFG.S.P.As........aFggG.EQKP.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
M4AA87_XIPMA/1807-1871                 ....QSGSNNLFGNSGAKAF...GFG.Q.T.Ss........aF..G.DQKP.....SG...TFSTGGGSVASQGFGSFSSPTK.PGGFGSPPVFG..
A0A091LZ03_CARIC/1470-1531             ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.AGGFGAAPVFG..
A0A099Z5J8_TINGU/1470-1531             ...s-QNSSSLFGNSGAKTF...RFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPSK.AGGFGAAPVFG..
H0Y837_HUMAN/768-830                   ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
H2QY24_PANTR/1915-1977                 ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
H9GW15_ANOCA/260-333                   ...t-QSTSSLFGNSGAKAF...GFG.S.P.AaaataaaassF..G.EQKPm...gAG...TFSSGAGSVAAQGFG-FSSPTK.AGGFGAAPVFG..
A0A3Q3SAY0_9TELE/1809-1871             ....QTGTSSLFGNSGAKTF...SFG.Q.T.P..........F..G.EQKS.....SG...TFSTGGGSVASQGFGSFSTPTK.SGGFGTAPVFG..
A0A6I8PXG4_XENTR/1105-1164             ...a-SNASNLFGNSGAKSF...GFG.G.T.S..........F..G.E-KP.....SG...TFSAG-GSVASQGFG-FPSPTK.TGGFGAAPVFG..
A0A3P9PRZ0_POERE/1792-1849             ....QSGSNNLFGNSGAKAF...GFG.Q.S.Ls........aF..G.DQKP.....SG...TFSTGAGSVASQGFGSFSSPTK.PG---------tl
A0A6G0I0M1_LARCR/728-790               ....QTGTNTLFGNSGAKTF...GFG.Q.S.S..........F..G.EQKP.....SG...TFSTGAGSVASQGFGSFSTPAK.PGGFGSAPVFG..
A0A3Q2HL89_HORSE/1347-1409             ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTQNK.TGGFGAAPVFG..
M3YMF4_MUSPF/1855-1917                 ...t-PNTSNLFGNSGAKTF..gGFA.G.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSAPNK.TGGFGAAPVFG..
A0A4U5VA42_COLLU/1811-1873             ....QTGTNTLFGNSGAKTF...GFG.Q.S.S..........F..G.EQKP.....SG...TFSTGAGSVASQGFGSFSTPAK.PGGFGSAPVFG..
G1P3G0_MYOLU/1891-1953                 ...a-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSAGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A553Q105_9TELE/1121-1181             ..nt--APASLFGSSGAKSF...SFA.G.S.S..........F..G.DQKQahglnSG...SFSSGAGSVAAQGFGSFNTPSK.SVG--------i.
NU214_HUMAN/1915-1977                  ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
#=GR NU214_HUMAN/1915-1977       SS    ...X-S-S---S--HHHHHT..S---.-.-.S..........S..S.SS-T.....TT...-S----XXXXXXXXX-XXXXXX.XXXXXXXXXXX..
A0A2R9B3B8_PANPA/741-803               ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
H2LQE1_ORYLA/1792-1855                 ....QSGPNSLFGSSSAKTF...GFG.Q.P.S..........F..G.EQKP.....SG...TFSTGGGSVACQGFGSFSTPSKsTSGFGSAPVFG..
A0A6I8NR43_ORNAN/1772-1833             ...t-SNSSNLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVAAQGFG-FSSPSK.TGGFGAAPVFG..
A0A437CUZ5_ORYJA/1785-1849             ....QSGANSLFGSSGPKAF...GFGgQ.P.S..........F..G.DQKP.....SG...TFSTGGGSVASQGFGSFSTPSKsTSGFGSAPVFG..
G3WXU7_SARHA/1949-2011                 ...t-PNTSNLFGNSGAKTF..gGFS.G.S.S..........F..G.DQKP.....AG...TFSSGGGSVAAQGFG-FSSPTK.AGGFGAAPVFG..
A0A673VU17_SURSU/1905-1967             ...s-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.DQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A673ZQ32_SALTR/1411-1478             .nqt---GTTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPTKqTGGFGSAPVFG..
A0A6Q2Z3A6_ESOLU/1822-1889             ...q-TGGTTLFGSSGAKTF...GFG.S.P.As........aFggG.EQKP.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A1S3FK94_DIPOR/1821-1883             ...t-PNTSNLFGNSGAKTF..gGFG.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPSK.TGGFGAAPVFG..
A0A674PAR7_TAKRU/1596-1659             .qpp--AANTLFGNSGAKTF...GFG.Q.S.S..........F..G.EQKA.....SG...TFTAGSGSVASQGFGSYSTPAK.PGGFGSAPVFG..
A0A3L8SDM9_CHLGU/1947-2008             ...v-RNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.AGGFGAAPVFG..
G1N1Z5_MELGA/1898-1959                 ...s-QNSSSLFGNSGAKAF...GFG.N.S.S..........F..G.DQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A670KDR2_PODMU/1633-1695             ...t-QNTSSLFGNSGAKTF...GFG.T.TaS..........F..G.EQKP.....MG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A2I0TRH3_LIMLA/1011-1072             ...a-SDSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A3P9A559_ESOLU/1823-1890             ...q-TGGTTLFGSSGAKTF...GFG.S.P.As........aFggG.EQKP.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A452HND8_9SAUR/1877-1938             ...s-QNTSSLFGNNGAKTF...RFG.N.S.S..........Y..G.EQKP.....TG...TFSSGGGTVAAQGFG-FSSPTK.AGGFGAAPVFG..
A0A485MGY6_LYNPA/1266-1328             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A3P8TGL7_AMPPE/1803-1865             ....QTGTNSLFGNSGAKTF...GFG.Q.S.S..........F..G.EQKP.....SG...TFSTGGGSVASQGFGSFSSPTK.PGGFGSAPVFG..
H2T2B6_TAKRU/1804-1866                 ..pp--AANTLFGNSGAKTF...GFG.Q.S.S..........F..G.EQKA.....SG...TFTAGSGSVASQGFGSYSTPAK.PGGFGSAPVFG..
F7EGH7_ORNAN/1915-1976                 ...t-SNSSNLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVAAQGFG-FSSPSK.TGGFGAAPVFG..
A0A6A1QGV5_BALPH/50-99                 ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.DQKP.....AG...TFSAGGGSVASQGFG-FSTP--.-----------..
A0A096LWA4_POEFO/1783-1847             ....QSGSNNLFGNSGAKAF...GFG.Q.S.Ss........aF..G.DQKP.....SG...TFSTGAGSVASQGFGSFSSPTK.SGGFGSPPVFG..
A0A0A0AWW1_CHAVO/1475-1536             ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A4X2L4D1_VOMUR/1935-1997             ...t-PNTSNLFGNSGAKTF..gGFS.G.S.S..........F..G.DQKP.....AG...TFSSGGGSVAAQGFG-FSSPTK.AGGFGAAPVFG..
A0A673A4L4_9TELE/1386-1449             ....QTGANNLFGNSGAKAF...GFG.QqS.S..........F..G.EQKP.....TG...TFSTGGGSVASQGFGSFSTPSK.PGGFGSAPVFG..
H2LQD9_ORYLA/1792-1855                 ....QSGPNSLFGSSSAKTF...GFG.Q.P.S..........F..G.EQKP.....SG...TFSTGGGSVACQGFGSFSTPSKsTSGFGSAPVFG..
A0A671VDS7_SPAAU/1528-1589             ...l--GATSLFGNSGAKTF...GFG.Q.S.S..........F..G.EQKP.....SG...TFSTGGGTVASQGFGSFSSPSK.PGGFGSAPVFG..
A0A673WML7_SALTR/1839-1907             .nqt--GGPTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
H2PTQ3_PONAB/1872-1934                 ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A2I4BAT4_9TELE/1794-1857             ....QPGTNNLFGNSGAKAF...GFG.Q.S.A..........F..G.EQKP.....SG...TFTTGAGSVASQGFGSFSTPQKtTGGFGSAPVFG..
A0A2I3RKQ3_PANTR/741-803               ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A4W5R372_9TELE/1827-1894             ..qt--GGPTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A1S3LCJ1_SALSA/1838-1906             .nqt--GGPTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A6A5EFH8_PERFL/1801-1863             ....QTGANTLFGNSGAKTF...GFG.Q.S.S..........F..G.EQKP.....SG...TFSTGAGSVASQGFGSFSSPAK.SGGFGSAPVFG..
A0A673WM85_SALTR/1839-1907             .nqt--GGPTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A3Q1BCI7_AMPOC/1789-1851             ....QTGTNSLFGNSGAKTF...GFG.Q.S.S..........F..G.EQKP.....SG...TFSTGGGSVASQGFGSFSSPTK.PGGFGSAPVFG..
H3BBA7_LATCH/1917-1970                 ...a-SNATTLFGSSGAKSF...GSG.S.S.T..........F..G.DQKP.....SG...TFSSGGGSVATQGFGSFSSPTK.TG---------..
A0A226P137_COLVI/1714-1775             ...s-QNSSNLFGNSGAKAF...GFG.S.S.S..........F..G.DQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A384CRJ1_URSMA/1879-1941             ...t-PNTSNLFGNSGAKTF..gGFT.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTANK.TGGFGAAPVFG..
A0A1S3KZN5_SALSA/1831-1898             ...q-TGGTTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPTKqTGGFGSAPVFG..
L8Y8B9_TUPCH/432-494                   ...t-PNTSSLFGNSGAKTF..gGFG.S.S.A..........F..G.EQKP.....AG...TFSAGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A1V4J6B8_PATFA/1855-1916             ...s-QNSSNLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A553Q0X4_9TELE/1055-1115             ..nt--APASLFGSSGAKSF...SFA.G.S.S..........F..G.DQKQahglnSG...SFSSGAGSVAAQGFGSFNTPSK.SVG--------i.
S9Y7D1_CAMFR/1526-1588                 ..tp--HTSSLFGNSGAKTF..gGFA.S.S.S..........F..G.DQKP.....AG...TFSSGGGSVASQGFG-FSAPNK.TGGFGAAPVFG..
A0A452QWQ0_URSAM/1839-1901             ...t-PNTSNLFGNSGAKTF..gGFT.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTANK.TGGFGAAPVFG..
A0A1V4J695_PATFA/1854-1915             ...s-QNSSNLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A093JBE0_STRCA/1471-1532             ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPSK.AGGFGAAPVFG..
A0A2Y9HB49_NEOSC/1911-1973             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A2K6PZ22_RHIRO/1900-1962             ...t-ANTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A665WPM8_ECHNA/1644-1706             ....QTGTSSLFGNSGAKSF...AFG.Q.S.S..........F..G.EQKP.....SG...TFTTGGGSVASQGFGSFSTPTK.PGGFGSAPVFG..
A0A1S3LDL5_SALSA/1838-1906             .nqt--GGPTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A5E4CX98_MARMO/1926-1988             ...t-PNTSNLFGNSGAKTF..gGFT.G.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
I3KCK6_ORENI/1501-1563                 ....QSSTNSLFGNSGAKTF...SFG.Q.S.S..........F..G.EQKP.....SG...TFSTGAGSVASQGFGSFSTPSK.PGGFGSAPVFG..
A0A452QWS4_URSAM/1550-1612             ...t-PNTSNLFGNSGAKTF..gGFT.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTANK.TGGFGAAPVFG..
A0A6Q2WZW2_ESOLU/1823-1890             ...q-TGGTTLFGSSGAKTF...GFG.S.P.As........aFggG.EQKP.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A1S3KZL8_SALSA/1830-1898             ..nq-TGGTTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPTKqTGGFGSAPVFG..
A0A452HNG4_9SAUR/1931-1992             ...s-QNTSSLFGNNGAKTF...RFG.N.S.S..........Y..G.EQKP.....TG...TFSSGGGTVAAQGFG-FSSPTK.AGGFGAAPVFG..
A0A3P8WRF5_CYNSE/1877-1939             ....QTGTNTLFGNSGAKAF...GFG.Q.S.S..........F..G.EQKP.....SG...TFSTGGVSVASQGFGSFSTPTK.AAGFASAPVFG..
A0A1S3L009_SALSA/1831-1898             ...q-TGGTTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPTKqTGGFGSAPVFG..
A0A3Q7X6Q0_URSAR/1912-1974             ...t-PNTSNLFGNSGAKTF..gGFT.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTANK.TGGFGAAPVFG..
A0A087XYI8_POEFO/1511-1575             ....QSGSNNLFGNSGAKAF...GFG.Q.S.Ss........aF..G.DQKP.....SG...TFSTGAGSVASQGFGSFSSPTK.SGGFGSPPVFG..
A0A4W5R3U4_9TELE/1827-1894             ..qt--GGPTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A493TE90_ANAPP/1616-1677             ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A315VTT8_GAMAF/1802-1865             ....QSGSNNLFGNSAAKAF...GFG.Q.S.S.........aF..G.DQKP.....SG...TFSTSGGSVASQGFGSFSSPTK.PGGFGSPPVFG..
A0A3N0YF24_ANAGA/1736-1798             ...n-TGSSNLFGSSGAKAF...SFA.S.S.S..........F..G.EQKP.....SG...SFSTGAGSVAAQGFGSFSTPTK.PAGFGSAPVFG..
A0A5F5Y682_FELCA/1346-1408             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A3M0JF95_HIRRU/1810-1871             ...a-SDSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.AGGFGAAPVFG..
A0A2I4BAP3_9TELE/1794-1857             ....QPGTNNLFGNSGAKAF...GFG.Q.S.A..........F..G.EQKP.....SG...TFTTGAGSVASQGFGSFSTPQKtTGGFGSAPVFG..
A0A384B544_BALAS/1768-1830             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.DQKP.....AG...TFSAGGGSVASQGFG-FSTPSK.TGGFGAAPVFG..
A0A3Q0GRC7_ALLSI/1640-1701             ...s-QNTSSLFGNSGAKTF...GYG.T.S.T..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A5F8HKG1_MONDO/1688-1750             ...t-PNTPNLFGNSGAKTF..gGFS.G.S.S..........F..G.EQKP.....TG...TFSSGGGSVAAQGFG-FSSPTK.TGGFGAAPVFG..
H3C4U1_TETNG/1638-1700                 ...q-PAANGLFGNSGAKSF...GFG.Q.S.S..........F..G.EQKV.....SG...TFTAGTGSVASQGFGSYSTPAK.PGGFGSAPVFG..
A0A3Q7SR70_VULVU/1920-1982             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A3Q3AWE4_KRYMA/1793-1855             ....QTGTTSLFGNSGAKAF...GFG.Q.S.T..........F..G.EQKP.....SG...TFTTGGGSVASQGFGSFSTPQK.TGGFGSPQVFG..
A0A3Q1FKP4_9TELE/1789-1851             ....QTGTNSLFGNSGAKAF...GFG.Q.S.S..........F..G.EQKP.....SG...TFSTGGGSVASQGFGSFSSPTK.PGGFGSAPVFG..
A0A452QWN1_URSAM/1853-1915             ...t-PNTSNLFGNSGAKTF..gGFT.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTANK.TGGFGAAPVFG..
H3CL16_TETNG/1627-1689                 ...q-PAANGLFGNSGAKSF...GFG.Q.S.S..........F..G.EQKV.....SG...TFTAGTGSVASQGFGSYSTPAK.PGGFGSAPVFG..
A0A5E4CXD6_MARMO/1318-1380             ...t-PNTSNLFGNSGAKTF..gGFT.G.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTPNK.TGGFGAAPVFG..
A0A2Y9F6D2_PHYMC/1928-1990             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.DQKP.....AG...TFSSGGGSVASQGFG-FSTPSK.TGGFGAAPVFG..
A0A4W5KMH5_9TELE/1829-1896             ...q-TGGTTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPTKqTGGFGSAPVFG..
A0A091DLG3_FUKDA/1907-1969             ...a-PNTSNLFGNSGAKSF..gGFA.G.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSAPNK.TGGFGAAPVFG..
A0A3Q7XSV7_URSAR/1911-1973             ...t-PNTSNLFGNSGAKTF..gGFT.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTANK.TGGFGAAPVFG..
A0A3P9CV31_9CICH/1833-1895             ....QTGTNSLFGNSGAKTF...SFG.Q.S.S..........F..G.EQKP.....TG...TFSTGAGSVASQGFGSFSTPSK.PGGFGSAPVFG..
A0A672UXL3_STRHB/1795-1856             ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.AGGFGAAPVFG..
A0A3Q1J086_ANATE/1835-1897             ....QTGTNSLFGNSGAKAF...GFG.Q.T.S..........F..G.EQKG.....SG...TFSTGGGSVASQGFGSFSTPTK.QGGFGTGPVFG..
U3JFF9_FICAL/1874-1935                 ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.AGGFGAAPVFG..
H3C706_TETNG/1285-1347                 ...q-PAANGLFGNSGAKSF...GFG.Q.S.S..........F..G.EQKV.....SG...TFTAGTGSVASQGFGSYSTPAK.PGGFGSAPVFG..
R0LZR9_ANAPL/1865-1926                 ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPTK.AGGFGAAPVFG..
A0A2Y9F5S3_PHYMC/1927-1989             ...t-PNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.DQKP.....AG...TFSSGGGSVASQGFG-FSTPSK.TGGFGAAPVFG..
A0A672G8W5_SALFA/1821-1882             ....QAGTNSLFGNSGAKPL...GFG.Q.S.S..........F..G.EQKP.....GG...-FSTGGGSVASQGFGSFSTPTK.PGGFGSAPVFG..
A0A0Q3X9G1_AMAAE/1727-1788             ...a-SDSSSLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.AGGFGAAPVFG..
A0A6Q2XSL0_ESOLU/1823-1890             ...q-TGGTTLFGSSGAKTF...GFG.S.P.As........aFggG.EQKP.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A452QWH3_URSAM/1905-1967             ...t-PNTSNLFGNSGAKTF..gGFT.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTANK.TGGFGAAPVFG..
A0A671VEI9_SPAAU/1537-1599             ....QTGATSLFGNSGAKTF...GFG.Q.S.S..........F..G.EQKP.....SG...TFSTGGGTVASQGFGSFSSPSK.PGGFGSAPVFG..
A0A1S3LDJ8_SALSA/1838-1906             .nqt--GGPTLFGNSGAKTF...GFG.S.P.As........tFggG.EQTA.....SG...TFSTGGGSVAAQGFGSFSTPAKqTGGFGSAPVFG..
A0A452QWL7_URSAM/1876-1938             ...t-PNTSNLFGNSGAKTF..gGFT.S.S.S..........F..G.EQKP.....AG...TFSSGGGSVASQGFG-FSTANK.TGGFGAAPVFG..
A0A091P954_HALAL/1453-1514             ...s-QNSSSLFGNSGAKTF...GFG.S.S.S..........F..G.DQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.AGGFGAAPVFG..
M7BGC9_CHEMY/1855-1916                 ...s-QNTSSLFGNNGAKTF...RFG.N.S.S..........Y..G.EQKP.....TG...TFSSGGGTVAAQGFG-FSSPTK.AGGFGAAPVFG..
A0A2K6LZF4_RHIBE/707-769               ...t-ANTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A4W3JLK3_CALMI/1491-1553             ..dh---SPNLFGNSGAKTF...GFG.N.S.S..........F..GtEQKS.....SG...LFSAGS-SVASQGFGSFASPTKpAGGFGAAPVFG..
A0A3Q4GMN7_NEOBR/1109-1172             ..qs-SQTGSLFGNSGAKTF...NFG.Q.S.S..........F..G.EQKP.....TG...TFSTGAGSVASQGFGSFSTPSK.PGGFGSAPVFG..
A0A2I4BAN7_9TELE/1794-1856             ....QPGTNNLFGNSGAKAF...GFG.Q.S.A..........F..G.EQKP.....SG...TFTTGAGSVASQGFGSFSTPQK.TSGFGSAPVFG..
A0A665WPZ5_ECHNA/1512-1574             ....QTGTSSLFGNSGAKSF...AFG.Q.S.S..........F..G.EQKP.....SG...TFTTGGGSVASQGFGSFSTPTK.PGGFGSAPVFG..
A0A665WNW7_ECHNA/1655-1717             ....QTGTSSLFGNSGAKSF...AFG.Q.S.S..........F..G.EQKP.....SG...TFTTGGGSVASQGFGSFSTPTK.PGGFGSAPVFG..
A0A2I3SSV6_PANTR/1915-1977             ...t-SNTSNLFGNSGAKTF..gGFA.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVASQGFG-FSSPNK.TGGFGAAPVFG..
A0A673A406_9TELE/1449-1512             ..pi--GANNLFGNSGAKAF...GFG.QqS.S..........F..G.EQKP.....TG...TFSTGGGSVASQGFGSFSTPSK.PGGFGSAPVFG..
A0A6I8NCW8_ORNAN/1826-1887             ...t-SNSSNLFGNSGAKTF...GFG.S.S.S..........F..G.EQKP.....TG...TFSSGGGSVAAQGFG-FSSPSK.TGGFGAAPVFG..
#=GC SS_cons                           ...X-S-S---S--HHHHHT..S---.-.-.S..........S..S.SS-T.....TT...-S----XXXXXXXXX-XXXXXX.XXXXXXXXXXX..
#=GC seq_cons                          ...s.ssoosLFGNSGAKTF...GFG.o.S.S..........F..G.EQKP.....oG...TFSoGGGSVASQGFG.FSoPsK.sGGFGuAPVFG..
//
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