GenomeNet

Database: Pfam
Entry: Orbi_VP4
LinkDB: Orbi_VP4
Original site: Orbi_VP4 
#=GF ID   Orbi_VP4
#=GF AC   PF05059.15
#=GF DE   Orbivirus VP4 core protein
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_5992 (release 7.7)
#=GF GA   27.00 27.00;
#=GF TC   27.40 375.30;
#=GF NC   26.10 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0063
#=GF RN   [1]
#=GF RM   9811835
#=GF RT   Capping and methylation of mRNA by purified recombinant VP4
#=GF RT   protein of bluetongue virus. 
#=GF RA   Ramadevi N, Burroughs NJ, Mertens PP, Jones IM, Roy P; 
#=GF RL   Proc Natl Acad Sci U S A 1998;95:13537-13542.
#=GF DR   INTERPRO; IPR007753;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Orbiviruses are double stranded RNA retroviruses of which the
#=GF CC   bluetongue virus is a member. The core of bluetongue virus (BTV)
#=GF CC   is a multienzyme complex composed of two major proteins (VP7 and
#=GF CC   VP3) and three minor proteins (VP1, VP4 and VP6) in addition to
#=GF CC   the viral genome. VP4 has been shown to perform all RNA capping
#=GF CC   activities and has both methyltransferase type 1 and type 2
#=GF CC   activities associated with it [1].
#=GF SQ   34
#=GS A0A173G2X1_9REOV/1-641  AC A0A173G2X1.1
#=GS A0A0H4M5E8_9REOV/3-629  AC A0A0H4M5E8.1
#=GS H9ZXQ5_9REOV/3-642      AC H9ZXQ5.1
#=GS E1AA91_9REOV/3-616      AC E1AA91.1
#=GS A0A0K1RGY4_9REOV/3-642  AC A0A0K1RGY4.1
#=GS A0A0H4MKA1_9REOV/3-621  AC A0A0H4MKA1.1
#=GS A7WPQ2_AHSV1/2-640      AC A7WPQ2.1
#=GS U5NXR5_9REOV/3-639      AC U5NXR5.1
#=GS S6C8V7_9REOV/2-642      AC S6C8V7.1
#=GS M1GUF3_9REOV/3-640      AC M1GUF3.1
#=GS H9ZXS5_9REOV/3-642      AC H9ZXS5.1
#=GS A0A0B5GGK4_9REOV/2-640  AC A0A0B5GGK4.1
#=GS Q2YH53_9REOV/3-645      AC Q2YH53.1
#=GS A0A097I4H0_9REOV/3-637  AC A0A097I4H0.1
#=GS A0A0H4M6N2_9REOV/2-622  AC A0A0H4M6N2.1
#=GS V9SCQ8_9REOV/3-642      AC V9SCQ8.1
#=GS W5QLW5_9REOV/3-637      AC W5QLW5.1
#=GS U5NGJ6_9REOV/3-645      AC U5NGJ6.1
#=GS VP4_BTV10/3-642         AC P07132.2
#=GS VP4_BTV10/3-642         DR PDB; 2JHP A; 3-642;
#=GS VP4_BTV10/3-642         DR PDB; 2JHA A; 3-642;
#=GS VP4_BTV10/3-642         DR PDB; 2JH9 A; 3-642;
#=GS VP4_BTV10/3-642         DR PDB; 2JHC A; 3-642;
#=GS Q9DSP6_9REOV/3-628      AC Q9DSP6.1
#=GS M4MDF2_9REOV/3-623      AC M4MDF2.1
#=GS W5QLY4_9REOV/2-634      AC W5QLY4.1
#=GS A0A077JHF2_9REOV/1-643  AC A0A077JHF2.1
#=GS A0A0K1RH66_9REOV/3-642  AC A0A0K1RH66.1
#=GS A0A346RV18_9REOV/3-647  AC A0A346RV18.1
#=GS C8TE61_EHDV1/3-642      AC C8TE61.1
#=GS G8DP06_9REOV/1-643      AC G8DP06.1
#=GS C5IWW0_9REOV/3-642      AC C5IWW0.1
#=GS A0A0X8GWG9_9REOV/2-637  AC A0A0X8GWG9.1
#=GS A0A0K1TPI9_9REOV/3-641  AC A0A0K1TPI9.1
#=GS H9ZXR5_9REOV/3-642      AC H9ZXR5.1
#=GS Q2Q1E1_9REOV/3-646      AC Q2Q1E1.1
#=GS A0A1V0CK02_9REOV/3-642  AC A0A1V0CK02.1
#=GS U3RA82_9REOV/3-642      AC U3RA82.1
A0A173G2X1_9REOV/1-641             .m-AHTVLYLSGRLAPITRDLFLPTWQIKKGSDLNTLWLENGQYFSDVYAIGDISHLTLRQLRGHNFLFVL.H.K.RDrV.FAK.D..GEVPRDIEV.DD...AQL..RS.SSFplpKQLERLIGHGRVSLRRFFGNAVRKYAFSVANEFNGSEVETVMQADFKKHRVYG.LPENPP.AIgIEK..P...RDA.PYD..DDKGTDEKLVSMLDYAVMSAD.VVYYVGCGDMRTLRTFARQDPKRFSRATWLCIDP.IVSKSWH.K.NVLCINQPIEDPSDL-RKLYLDKRGESILIWDVRSDRGNMTD.WEWEDFCQEQDELGDRVALKNSDWLAYSIVKRRVPK.FKPSVE.MWSSLLIPQPGAPEDMYELRNII.KGQGFSYVDRSHIPEPKSQRISVNQ.MRKLV-LYHGKHRGKKLKISLIEYLHITRRDGLSVVSA-RSAHLFYLTNKRNQDRHFAIAEVIRAAEISTLWIGHDIPTGYDDFTWDRRDVMTRYSKDDTMVLDGNGFMLFMMWKID..S.-.KLKYIRYDPYWAENFAVVFKKRTKFEPVPDVSLCRFIGIRAESSMLRIRTDMIHHAPDVLKDMGLDLSGHLYVTLASGRYCTDLTWWFDMILKWSCEEKDTKLRLLNESGAEVIEWKKEKEGEPWHILPDLIAALRQAE..-..-------..--.---------iqnfgglscqyrkwvqylr....
A0A0H4M5E8_9REOV/3-629             ri--HAVLHLSRDAHTILKDSFLPRLDLSDRPDLNTLWIRNGQFSGDVIATGPVDSYTLRQLRGHGFIFIG.T.R.GA.R.-I-.-..RTKTCAVQP.DI...ILT..KN.MTT...KQAETKIGEIRTRMRRVFGNALRQYASRLCTVFHGSEVETLVAMDPLTVEVCG.LPKRPP.VG.TSR..S...RIS.YTH..-DSGVDEKLVSMLDYALFGFR.TVIYVGSGDGRTIKRFFQQHPKRAASLRWICIDP.IQPVYTK.H.-VLHYREEITHP-A--QLQRFRSHDPTIMLWDVRSDRGELDD.LGWEELTAREDALGRRVALENREWLNAALLKTRVPF.SD--FT.IETSELLFQPGAPAEMYEVRNWL.QLDGPGLRRDWLGPPREL--VVDRAwLVEGCQRLHGRDRGRRMKTEMIAYLHIKRMNGLDDTRVGQRADLFYLTNAQNPA--ELVEEAISRSTVCTLWAAGDPTYDYDDWVYDPRLAMLKHSTQERMVLDGLGFMLFGMWQ--..G.W.IEETLSFDPWWAANFIVIFPRS-RFPPVPDVSLCRFVGLRTASSHLRIREFDAHAKADLVKSTGLDLSGHLYVTLHTGWYTCDLVWWFNMILEWSVQDADSKRRDLDAAGAQVLEWKEDRASDPWHLRCDLVAALRIYQ..E..REERRSPylASlVTPWVEKL-r......................
H9ZXQ5_9REOV/3-642                 ..EPHAVLYVTSELVPLVELAFLPKWELSGDESLNEFWLKNGHFSQDVYCYGRISKWTARQLRAHGFIFIS.T.K.SS.V.KLK.D..CLMPVDVRI.PL...DFL..IR.YDV...KKFETFIGRKRIGLRKCFGNILRRYALSKANYFHGSEAETLNIANPRIHHVKG.LPKDPP.TH.YSW..H...SKV.MSD..DDEGTDEKLVSMLDYMMYSAE.EVHYVGSGDLRTLYMFKKRNPRRFNQATWHVYDP.IAETTEL.S.NVIVHKEPVTHHAQLMANINVLKRVERILIWDVSGDRGPLTS.EEWEEKRDREDRKGESIALELEGAFSLALIKHRVPQ.HTDKYW.CTTSALIPQPSAPTGMYELRNII.RLNGFSYVNRSHIPPHAMVRLNARD.MQAMCERFHVSGKGKRLKKSIFEFLHIEREDGLAADLQVPRADLFYLTCAENRNRWDDVKTTVMASQISTLWVGRNRLFDYNDYPVMRSEVMLIFSSRDIRVFDGNGAVLFLMWKYP..Y.M.FDKTLNYDPAWAANFAVMMKEPVPQPAVPDLSLCRFVGLRIASSVIRLNNPSIHSVPDELKAIGLDLSGHLYMTLVSGAYLADLRWWLEMILEWSSQDGEKKKRDIEKAHGEVIEWKDDMAFKPWHVRNDLIAALREYM..K..YCTEREK..PS.LTGWIMYL-q......................
E1AA91_9REOV/3-616                 .g-PHTVILLHQSLRRYRKELYGPSFQIRRDWTLNDLWRENGRYATDVYAEGDVSWLTIRQVRAHGIIFVG.P.AgAR.F.PMR.D..AVLSPDVII.-R...SV-..--.RDA...KDLETQIGRGRIKLRRTFGNAVRNYAWARATYFHGSEVETVTHGDIRGKKLFG.LPPRAP.L-.-AY..P...EVD.VEF.aSDGPVGEKLVSMLDYAVHGYD.TVLYVGAGDGRTVTQFSRKDPERFRRTRWVLIDP.IVREEGW.PsNVTTSRRRVDTPRDLARYQ---CNGATLLLWDVRSDRGTQAD.REWEETCRREDDLGESVAIANSAWLDSALLKRRVPF.S-DVLR.CTVSVLCFQPGAPADMYELRSFL.ALSGHEWLGEPM----SVT-LPTEP.LRRRIQRYHGKDRGRSLRTRLIQTLHIEQCDGLQSEL-TPRADLFYLTNRRNT--PESVFRVVSRSEISTLWVG-ARLLSYDDYTMSGAEVMLRCSTESHMVVDGLGFLLLLMLW--..G.E.VANTLSFDPGWAGQYAVVFRRR-RVPPVPDVWLCRFIGLRANSSLLRIREPCAHDTPDLIKRMGIDLSGHLYVSLVTDKYVADLRTWFQMILTWSVLGAEEKKDAIARAHGEVIEWKDQMESKPWHLREDLIAALRAFR..-..-------..--.---------llapehlhpyid...........
A0A0K1RGY4_9REOV/3-642             ..EPHAVLYVTNELSHLVKSGYLPLWHLTGDESLNDLWLENGKYATDVYAYGDVSRWTIRQLRGHGFIFIS.T.H.KS.V.QLA.D..IIKTVDVRI.SR...EVV..KS.QDM...KMFENEIGRRRIRMRKGFGDALRSYAFKVAIEFHGSEAETLNDANPRLHRVYG.MPEAPP.LY.MEY..A...EIR.NKF..DDEPTDEKLVSMLDYIIYSAE.EIHYVGCGDLRTLMQFKKRSPGRFKRVLWHVYDP.IASQCSD.T.NVVVHNVMVDSKKDILKHMNFLKRVERLFIWDVSSDRNQMDD.DEWESTRFAEDRLGEEIAYDMGGAFSSALIKHRIPA.MRDEYH.CISTYLLPQPGADTDMYELRNFM.RLKGYSHVDRHMHPDAAVMKVVSRD.VRRMVEMFHGKDRGRFLKKRIFEHLHIVRKNGLFHESDEPRADLFYLTNRCNMGLEPSIYEVMKKSTIATVWVGRTPLYDYDDYSLPRSTVMLNGSYRDIRVLDGNGAILFLMWKYP..D.L.IKKDLTYDPAWAMNFAVSLKEPIPDPPVPDISLCRFIGLRVESSVLRVRNPTLHETADELKRMGLDLSGHLYVTLMSGAYVTDLFWWFKMILEWSSQGKEQKIRDLKRSAAEVIEWKEQMAERPWHVRNDLIAALREYK..R..RMGTREG..AS.IDSWLELLR.......................
A0A0H4MKA1_9REOV/3-621             ..EPHAVIAVAPSLRRFLRDVHLPIWRPATAE-LNELWRQNGRYQTDVYFDGSPESLTVRQARAHGFLFVG.G.S.AErF.A--.-..-LKDVAIRP.DI...VIR..RA.CDA...KDFETQIGQSRVRMRRSFGNIIRGYAWTRATYFHGSEVETVVRDHLVEKRIYG.LPPTPM.LA.APR..TqclEVP.S-A..CDGPVDEKLVSLLDYTCHRVK.NVIYVGAGDGRTLLSFRRKDPTRAQAIHWTLIDP.ITPDIPH.D.NVLVVRTAVRQPSDIVP---YRRDGPTALIWDVRSDRGTLDD.DSWERRAASEDLLGRAVAE-GNRWLDISSIKLRIPT.GGLLTL.RASCV-TFQPGAPSDMYELRVI-.----YSH-QRDWLPVSNITLDL-DW.IRRMVPLVHGRDRGRRLRTSLIQFLHIERRDA-FHCIETPRADLFYLTNARNSGA--DIFTVVERSEVSTLWASREPTLEYDDIPVSRTEVMLRCSTETHCVVDGLGFVLLLMFLHE..-.-.LDLETSFDPQWAARFIVVFRRR-DLSAVPDVWLCRFIGLRVASSIIRIRDPGIHRVADLVKSTGLDVSGHLFVTLVSGAYAVDLICWFRMIVEWSVLGREAKLKQLAQAGAEVIEWKDDRADQAWHRPEDLRAALKIFS..R..M------..--.---------cpslsafvearlddlr.......
A7WPQ2_AHSV1/2-640                 ..EPYAILYVTQEIEYLLKDSFLPKWELDGIKDLNTLWLERGRMACDTYATGKIEQWSVRQLRAHRFLFIS.T.K.RK.I.RLK.D..CTISPDIFI.LK...KEL..KE.YNM...KRFETLIGRRRVTLRKSFGNMLRAYAFQHVTVLHGSEAETLSYADPKRHVVKG.QPKAAP.MY.DHP..D...RWW.RDV..DDGPTDKKLVSMLDYIIYSAD.EVYYVGCGDLKTLEQFASRDRKRFDRIKWICIDP.IAPETSY.A.NVKVVKEKVVSARD-LKHYLMRDEVERLLIWDVSADGLK-GT.IEWEKRRFKEDRNGENIAEALCADFALALIKHRIPE.ESDEYI.CRSSWLLPQPGAPITMYELRNLM.RLDGYSHVERKHIPRAYVRKIDAEV.ARRLVEEYHGEDVGRLLKRSLYENIHIERADGLTDGDERTRADLFYLTNMRNAAFMHDVYRVVEKSFISTLWVSNRQNFTYDDVPVNRNFITLRFSKKNRRVLDGNGAILFLMWQHP..K.D.FPKTMNYDPSWAENYAVIFYHALT-SPVPDLSLCRFIGLRLMSSTLRINSDRAHQVTDILKKLGLDVSGHLFICLMSNSYVADLDWWFRMILEWSVKDREGKLAALSEAKAELIEWKDEKADEPWHIKNDLLAALFEFMyfA..KHFEINE..RY.VESWIQYLR.......................
U5NXR5_9REOV/3-639                 ..EPHAVIYLTNELVQVILHAFLPKWRLTGAETLNDLWLQNGLYHYDVYAYGEISRWSYRQLRGHGFIFVS.T.R.KR.I.KLA.D..GEVEVDILL.KS...TFI..H-.GTT...KQLETEIGRRRLRLRKGFGDILRKYAFMVSKVLNGSEAETLNDADYKIHRVCG.LPAKPP.VY.GDG..C...EIS.YRR..D-GGTDEKLVSMLDYMIYSAN.EIHYVGCGDLRTLLKFKKRSEKRFNQVEWHVYDK.IVKYIDL.P.NVRIHNHFVYKASDIMKNVDVSKKRERLLIWDVSTDRIAHTN.LEWDAHRGREDRLGEVIATELEGMFALALIKHRIPT.NIESYR.CVTSHLIPQPGAPHDMFELRNVI.RLSGFSWVDRTHIPAYKYINVCSET.CRKMVVKYHGTDRGKELKKRLFEYLHIERVNGLHQKNEESRSDLFYLTNVVNKNDVKLIDGVVKTSMISTLWVSKRELYDYEDFPFERNEIMLRFSSRERRVFDGNGAVLFLLWNYP..H.I.FTRNDHYDPSWAMNFAVIMREPVPDPPVPDVSLCRFIGLRAESSQLRLNSPSTHEASDVVKELGLDLSGHLYVTLMCNGYIADLMWWFAMILKWSAQDRDKKMYDLKISKATIIEWKEEMASKPWHVKNDLIGALREFG..Y..QKKQLEP..QA.L-SWIEALR.......................
S6C8V7_9REOV/2-642                 ..EPCAVFHLSGNLTHLLPEVFLPIWDLSRIKVLNDLWIERGKWVSDVYALGDVSKWSIRQLRSHRFIFIS.T.N.TR.V.AVK.E..EWIHPDVKI.PR...DKA..NG.LSA...KELETIIGTQRLKLRKKFGDMLREYAMVTCVEFHGSEAETLNFVDPKKQKVFG.LPRMPY.TY.NNP..K...KTW.RDA..EDQGTSEKLVSMLDYGVWSAD.QVHYVGSGDLRTLKQFAQSDPKRFRRIEWFCYDP.ISPAGDL.S.NVYTFKRCVTSPSDLNITKRECANVERVFLWDVSTDKGSLDS.IEWCKKREKEDRLGEAIFRAIAGMFSYGIIKHRVPE.GNEDYC.IYTSDLLPQPGAPHDMYELRNLV.MGRGHTWVDRSHLMQPQFKWVNPTT.CRRMVIDIHSKHLGKIEKKLLYEYLHITRRDGLTHEGQGKRADLFYLTNRCNAPYKEKIVSVAKVSEIATLWVSRMTTPDYDDLPVSRSELMLRLSGNGKILLDGNGAILFLMWRYP..N.R.FKRTTNYDPAWAECFAVSFREDIPEDPIPELSLCRFIGLRGESSRIRLNAVKYHFVPDMLKSMSLDLSGHLYITLVSGSYVADLEWWLHMILRWSQKNAEEKVSSIKRLKGELIEWKEEKANSAWHLREDLIAAFRAFQ..A..H------..--.---------cdvfgidddhiqpwvsaa.....
M1GUF3_9REOV/3-640                 wq--HAILYVSQSLRTYLKDAFLPVWVLTGRETLNEMWINNGKFNTDIYAYGPLTKFSIRQLRGHGFIFIS.K.K.NE.ViQTR.DgpAPKDIEVTI.PK...TG-..--.ADL...KWLETQIGRGRVLLRKAFGDALRKIALRECVNLHGSEAETLMQADPHRHRVYG.LPRPPPaIG.IEV..S...RVQ.PYI..NDCKTDEKLVAMLDYYVYSAD.VVIYVGAGDLRTLKHFKKKDPQRYYRVQWHCIDP.ISEEMQD.D.NVHVHKIMMTSPNVLATFRPKHDNVEVALIWDVRSDRGVLGD.AEWERRCETEDRFGEKVAWDNREWLSSALIKLRVPL.RNGTLR.ATTSATFPQPGALDNLYELRNYM.RLYGFSHVDRTHIPIARELDLPIIT.LRMLVTNFHGESRGKKLKRSLLEFLHITYLNGLDAADNFKRADMFYLTNKQNEGRLAAIADVVNESKLATLWVGDQA-MDYDDFSYSARRAMLQFSTRKKLVLDGNGFMLFCMWKKS..H.I.INDGAKYDPWWASQFAIIYETDKGFEPVPDVSLCRFIGLRQHSSQLRLRSSSAHEKADMIKRMGLDLSGHLYVCLYSNAYVTDLQWWYRMITEWSCLPKEAKKSTLNKAGAEVLEWKEDRADLPWHKREDLIAAMKLI-..-..-------..--.---------rehafsdiprekldewiq.....
H9ZXS5_9REOV/3-642                 ..EPHAVIYTTKELEPLIKGSFLPVWELSGEESLNELWIQNGKYSSDVYCCGPIKRWTYRQLRGHGFIFVS.T.E.KM.I.QLA.D..ISHFVDIRI.PK...VIL..SS.KDV...KKFETEIGRKRLKMRKMFGDILRRYALLKAIELHGSEAETLNQANPRVHEVYG.LPEIPP.HY.DEF..V...TNY.DAF..EDEPTDEKLVSMLDYLMYSAE.EVHYVGSGDGRTLELFRKRSPERFNRAIWHLYDP.IAPQTTH.N.NVFVHRAKVEDKRILLSNMNMLKRVERLLIWDVSSDRERKTD.TEWESERFGQDRLGEEIAYELSGAFALALIKHRVPQ.LRDTYN.CISSIIFPQPSAPREMYELRNLL.NLRGYSHVNREHIPSARTIEVRVNR.LRDLVEKFHGIHRGKKLKKQLYEYIHIMYKNGLRAEGEQTRADLFYLTNSQNFGRWREIKEVILKSQIATLWVGRAPLFDYNDYVVDRAQAMLELSTRETRVLDGNGAVLYLIWKYP..E.I.FKRGLTYDPAWAMNFVVTLREPIPHPAVPDVSLCRFIGLRVESSLLRLRNPRLHEIADELKKIGLDVSGHLYVTLMSGAYATDLYWWFYMIMMWSPQGRENKISDLKASKSEVIEWKDEMADKPWHLRPDLIAALKEYD..F..KTRIKGM..AP.IDRWIDLL-h......................
A0A0B5GGK4_9REOV/2-640             ..EPYAILYVTQEIEYLLKDSFLPKWELDGIKDLNTLWLERGRMACDTYAVGKIEQWSVRQLRAHRFLFIS.T.K.RK.I.RLK.D..CTISPDIFI.LK...KEL..KE.YDM...KRFETLIGRRRVTLRKSFGNMLRAYAFQHVTVLHGSEAETLSYADPKRHVVKG.QPKAAP.MY.DHP..D...RWW.RDV..DDGPTDKKLVSMLDYIIYSAD.EVYYVGCGDLKTLEQFASRDRKRFDRIKWICIDP.IAPETSY.A.NVKVVKEKVVSARD-LKHYLMRDEVERLLIWDVSADGLK-GT.IEWEKRRFKEDRNGENIAEALCSDFALALIKHRIPE.ESDEYI.CRSSWLLPQPGAPITMYELRNLM.RLDGYSHVERKHIPRAHVRKIDAEV.ARRLVEEYHGEDVGRLLKRSLYEDIHIERADGLTDGDERTRADLFYLTNMRNAAFMHDVYRVVEKSFISTLWVSNRQNFTYDDVPVNRNFITLRFSKKNRRVLDGNGAILFLMWQHP..K.D.FPKTMNYDPSWAENYAVIFYHALT-SPVPDLSLCRFIGLRLMSSTLRINSDRPHQVTDILKKLGLDVSGHLFICLMSNSYVADLDWWFRMILEWSVKDREGKLAALSEAKAELIEWKDEKADEPWHIKNDLLAALFEFMyfA..KHFEINE..RY.VESWIQYLR.......................
Q2YH53_9REOV/3-645                 .s-THAVIYLARGFEPQLADVFLPILQITGKEDLNSLWKAIGMYNTDIYCQGTLQKWTVRQLRGLGFIFCA.R.R.GQ.T.ILTlS..GPAPIDIVF.PS...NYP..RD.TNS...KEFETKIGVDRVHLRRKFGNILRDWAFKFAIEFHGSEAETVMMADPRRHTVYG.KPTSPP.AL.GIP..S...QID.TPY.sSDHPTDEKLVCLLDYMTYSAD.VVYYVGSGDLRTLQKFRAKDQKRFERVTWFCIDP.IVGESFA.P.NVICMRLLITDP-SHLRGLKKPGNLEHMLLWDVRSDKTGHDS.EAWERITAYEDDLGQYVTMCNRDWLSLACLKLRIPV.TKQIFN.VFTSLIVPQPNAPITMFELRSIV.RLNGFSHVDRSHIPLGRVITVQHAD.CCTLVKNFHGSMRGKRLKRNLLEYLHITQRDGLEHRSGLPRVDLFYLTNNCNRNRVDIIDEILETSALATVWIGNAVHTGYDDFVYSPQKLMLRFCSQQRMVLDGNGFVLFLMWKGA..LgK.DGYKLSYDPAWASQFGVVTLRTYPTDLAPDVSLCRFLGLRRYSTMLRLNTDHVHRKPDILKSLQLDVSGHLLISLISGAYCFDLYWWIKMIRDWSVLPETDKLMMISQYKAEVVEWREDKANEPWHQVEDVRAALIL--..-..-------..--.---------aaelhlpavcasdylrwleilr.
A0A097I4H0_9REOV/3-637             ..EPRAVLYVTQDLEHLLSDVFLPVWKLNGTETLNDLWLANGKYATDVYAYGVIQWLSYRQMRGHNFILIS.S.K.RK.I.KLS.D..AIVNADIMI.TS...ETV..QS.GNS...KVFETELGHKRIKLRQRFGNILRQYALMSATYLNGCEAESLNVSDPKQHICYG.LPEKPP.HY.DNN..Y...VID.YTI..D-GATDEKLVSMLDFYIYSAD.EVFYIGSGDLRTMLSFKKRSPTRFNRIVWYCFDP.ITPNVSL.P.NVYTFREIVTSKEQLLRHCKG-NNVERCLIWDVSCDRGGLDD.SEWEKQRMNEDRLGEEIARDLSSVFAYALIKHRIPQ.FCERYL.CYSSYLFAQPGAPRDMYELRNFI.KLKGFIHVERIHLREPWIRRIEVKQ.AVTLVENCHGRDKGRVLKKRMYEFLHIIPYDGLYSEG-TPRADLFYLTNRRNQGAMNAISRIISTSEIATLWVGRRVLVDYDDFTYDRNSAMLKFSTERTRVLDGNGAVLFLIWRYP..D.V.FKKGLSYDPSWAMNFMVAIAEPVPDPPIPDISLCRFLGLRTDSSMLRLNSPNVHKVPDILKNMGLDLSGHLYITLVSNFHLTDMRWWFQMIIYWSSKDKAGKLSDLRKSKGEVIEWKTEMEEKPWHVRNDLIAALSEYK..K..VS--EHV..LQ.IEEWIQYLR.......................
A0A0H4M6N2_9REOV/2-622             ..DPHAVIHISSSLAHLLADAYLPVWRLTGTETKNQLWIQNGTYATDVYATGPIRGMPYRVARAHGFLFVGgA.N.DK.V.TLA.D..ATLTPDIRV.-R...NV-..--.RSM...KELETQIGRQRLRLRQRFGDLVREYAWTRAEFFNGSEIETLARDLACEKRILG.CPQMPP.LA.NSL..S..dEIR.PLQ..GDGPTDEKLVSMLDYATFRVD.TVIYVGAGDGRTVKQFRKKEPERFSRIRWILIDP.IICEAFD.T.NVSCHKDCIRQEKDLLPYRT--ARGTTLLLWDVRTDRGEMSD.RHWESQCKHEDRLGVSIAEGNRAWISLALLKTRVPF.-DDAMD.VLTSALLFQPGAPQDMYEVRNLL.VFSGRPWLPRP-----TRQRVDLNR.VRLGVQMYHGVMRGRVLRRLNCQYLAIETSDGLKNE-HGPRADLFYLTNEGN-GPPESLINVALKSEISTFWIRQSRTLSYNDRPFPAQMLMLRCSTDSHMVNDGLGFILWMIWKG-..-.Y.CSPTPSFDPSWAASFAVVWR-RVYTPCVPDVSLCRFVGLRSVSSTLRIREPHAHEYSDLVKSMGLDLSGHLYVTLVSGAYISDLRTWINMILKWSNLPAQEKVAQLEKHRAQVIEWKEDRADQPWHLREDLIAALRAYA..R..LSG----..--.---------ddvsvwiklln............
V9SCQ8_9REOV/3-642                 ..EPHAVIYVTEELTHLIKGSYLPVWEIRGNETLNELWLTNGKYSSDIYAHGKIETWSYRQLRGHGFIFVS.T.R.KT.V.QLS.D..VLMNVDVRI.PK...DII..KG.VDV...KAFETIIGRRRLKLRKTFGDVLRSYAFRKAIVLHGSEAETLNDANPRLHKVYG.LPKEPP.MY.HEG..L...CAR.GPF..LDEPTDEKLVSMLDYAIYSCE.EVHYVGSGDGRTVMCFAKRSPERFHRIVWHLYDP.IAVDLKY.N.NVYVHRMFVDGKRDIMKNVNLLKRVERLFIWDVSTDRGDMSD.REWERHRFAEDRLGEEIAMSTSGLFSMAIIKHRIPR.FMEQYH.ITSTYLFPQPGAPSDMYEVRNVM.RLRGYSHVDRTRHQDAQVHTIVQKD.VCKLVEWYHGREKGKKLKKMLFEYLHIMRENGLYAENEEPRADLFYLTNRCNYDMWREQKRVLRVSQIATMWVGGDQLFDYDDYSVPRALLMLECSHADVRVLDGNGAVLFLIWRYP..D.M.YKRGLNYDPSWAMKFVVTMKEPVPDPPVPDISLCRFIGLRVESSLMRVRNPRVHQVNDELKRMGLDVSGHLYVTLLSGAYATDLLWWFKMILEWSSQNKEEKIRQLKASKAEVIEWKDEMAERPWHVRNDLIAALREFK..F..KIQKRWD..AP.VESWLDLL-q......................
W5QLW5_9REOV/3-637                 ..EPHAVIYLTAEFEPLLHECYIDVWRLKGNETLNDVWLENGRFSSDVYALGPIVKWTIRQLRAHRFLFVS.T.S.KK.I.RVK.D..CEIAPDVYI.TR...ETL..-L.KGM...KAVETEIGRKRVRLRKSFGDVLRTYALRNAVVLHGSEAETLMVADPKVHQVYG.LPREIP.ND.MQP..D...KTW.TDA..DDSPTDEKLVSMLDYMIYSAE.EVHYVGAGDGRTLAEFKKRDPNRFRRVQWYCYDP.IF-KMED.V.NVHGLRKLVRTSKDIELT---PGRKDRVLLWDVSADSENRADpRAWERERLLEDERGACIALALRTDFSLACVKFRIPN.RRTVVL.PT-SMIIPQPGAHEMMYECRNIM.RLEGFSRVNREHLPTVVTRDIDCDA.LRGMVRNYHGRWRGRVLKRVIFEGLHIMKQNGLDWEGELPRSDLFYMTNRANVGREVDIERVARESVISTVWTSALQNFDYDDFKVHRNKLMFWNVGNDRLIFDGNGLMLFLMWRYP..G.I.CKKTVNYDPCWAERYGAVIQEAIPEPPIPELSLCRFVGLRKQSSWLRLNASRAHYKSDEVKQLGLDLSGHLYIALMSEGYVADLRWWFRMILEWSAQDRAKKIADLAKLNGEVIEWKEEKASEPWHKREDLIAALRAF-..-..-------..--.---------isfspyhlvpvasiirhldg...
U5NGJ6_9REOV/3-645                 .t-PHAVIYVAKGFEHQLNETFLPVIRLTGKETLNTVWRILGKHQTDIFVTGNIIPWSLRQLRGLNFIFVG.R.KgQK.I.QTR.D..GIAPLDIAF.PA...IYP..KD.ASA...KSFETKIGTDRVGLRKKCGDLVRKWCTTFAVEFHGSEAETLMCTDPRRHRVYG.LPIPPP.GL.GFS..T...TVKlPYL..DDGPTDEKLVCMLDYFVYDFD.VIYYVGAGDMRTLMKFRSKDIERFNRTTWVCIDP.ISPACSY.Q.NVVVMPILLETPEQLRGLMRFGEGLTHGLIWDVRSDRGDSSN.EEWEMRARNEDIMGTLVAMANRDWLCMACVKLRIPM.GEEVFT.VCTSLIVPQPMAPATMFELRTIL.KLNGYSRIARDHLIDARDVTVTHDE.CVTLVRNFHGFSRGRKLKRAILQFLHIMRADGLNHRSVLPRVDMFYLTNRRNNSNIPLINYILSTSAFATVWIGEETQTGYDDFRYSSTALMLKFCNEERMVLDLNGFILYLMWKGClgD.E.GF-RESYDPAWACKFGVVCMRRGPIEIVPDVSLCRFVGLRTHSTMLRLNTDYVHKRPDILKRLELDVSGHLYISLVSGAFCFDLLWWIKMIRDWSSLDEVGKLYLIAQCKAEMIEWREEGANEPWHKLEDLRAAL----..-..-------..--.---------ilastldlsgvrrrdferwidml
VP4_BTV10/3-642                    ..EPHAVLYVTNELSHIVKDGFLPIWKLTGDESLNDLWLENGKYATDVYAYGDVSKWTIRQLRGHGFIFIS.T.H.KN.V.QLA.D..IIKTVDVRI.PR...EVA..RS.HDM...KAFENEIGRRRIRMRKGFGDALRNYAFKMAIEFHGSEAETLNDANPRLHKIYG.MPEIPP.LY.MEY..A...EIG.TRF..DDEPTDEKLVSMLDYIVYSAE.EVHYIGCGDLRTLMQFKKRSPGRFRRVLWHVYDP.IAPECSD.P.NVIVHNIMVDSKKDILKHMNFLKRVERLFIWDVSSDRSQMND.HEWETTRFAEDRLGEEIAYEMGGAFSSALIKHRIPN.SKDEYH.CISTYLFPQPGADADMYELRNFM.RLRGYSHVDRHMHPDASVTKVVSRD.VRKMVELYHGRDRGRFLKKRLFEHLHIVRKNGLLHESDEPRADLFYLTNRCNMGLEPSIYEVMKKSVIATAWVGRAPLYDYDDFALPRSTVMLNGSYRDIRILDGNGAILFLMWRYP..D.I.VKKDLTYDPAWAMNFAVSLKEPIPDPPVPDISLCRFIGLRVESSVLRVRNPTLHETADELKRMGLDLSGHLYVTLMSGAYVTDLFWWFKMILDWSAQNREQKLRDLKRSAAEVIEWKEQMAERPWHVRNDLIAALREYK..R..KMGMREG..AS.IDSWLELLR.......................
#=GR VP4_BTV10/3-642         SS    ..----EEEE-CCCHHHHTTSSS-EEE--ST--HHHHHHHHTT-SS-EEEES--TSS-HHHHHCTTEEEEE.S.S.SE.E.E-S.S..SEEE-SEE-.-S...TTS..TT.T-H...HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-SEE-S--HHHHHT--TTT-EEEE.------.-B.SST..-...---.---..---B-S-HHHHHHHHH-SS-S.EEEEET-TTSHHHHHHHHHSHHHHHTSEEEEE-T.T------.T.TEEEE----SSTHHHHTTS-TTS---EEEEE-----------.---TCHHHHHHHHHHHHHHHCBTTECEEEEEEE--S.S-SEEE.EEESEEE--TT--TT--EEEEEE.E-SS--SS--TTS---EEEEEEHHH.HHHHHHHH--TT-BHHHHHHHHHHHHSEEB-TTT---SS-EEE-S-TTBGGGTT-HHHHHHHHCC-SEEEEE---S--TT--B----HHHHHHHH-BSSEEEEEHHHHHHHHHHHST..T.T.S-SS----HHHHTTEEEEEE----SS----TTT---TTHHHHHHHHHHHS----------------HHHHHHHHHHHS-----HHHHHHHHHTTSSS-TCCCTTTTTTTT---S-------------HHHHHHHHHHHH..H..C-SSSS-..ST.THHHHTTTS.......................
Q9DSP6_9REOV/3-628                 ps--HVVLYLSRSLCRYLGAGA-DLLTLRGAEDPQWLWQASSTRFKDFYCTGPIHNFSIRQLRGYSFLFVV.Y.EgDR.V.RCL.D..GDVPRDVVItPH...QLS..SL.KGQ...KDLESLIGKARVPLRRTFGDEIRKHAATFCDSFSGSEAETIMMLRTDRYHISGrTPNPPN.SN.FPY..P...SLP.FKG..DRECGD-KLVAMLDYLIPHAEyRAIYVGSGRGDTVQSFARRSPRRFSLGQWVLIDAnVSWEAPP.S.NVLLYQGYVHSVDDVAQFLV-PGALNQILIWDVRTDNVGLSK.FQWEERAMEQDMLGENTAEALQSELAAALLKHRIPQ.FSDNRDeVFTSTLLPQPGAPAGMYEMRNFC.RLDGPRTFNRSI-PTAQRHPIKYDE.CRAMVEELHRSRRGANLRRRIFEFLHIQDEDGLLHFG-EKTAHLFYLTNSCNEEHIGDLRAIVRSAGIATLWVGG-EIFGYPDFSYDRRLAIADFCTKDRMVYSGLGYILLLMWEG-..-.S.VPTSLPFDPWWADSFAVIVKRR-EVPFLPDVSLCRFIGIRERSSQLRLRFREVHDVMDVVKSLGVDASGHLFIGILSSNYVFDPYIWVNMIMLWSQQSRTDKIRDIESHGAAVIEWDRSHMDKPWHSFDDLTASLV---..-..-------..--.---------algkilppqry............
M4MDF2_9REOV/3-623                 .g-SHTVLLLHHSLRRIRKEVYLPWITIRREWTLNELWKENGKYGTDVYADGDVSRLSIRQARAHGLIFVG.P.R.NA.R.F--.-..LLRDAEVGP.DV...VVD..PA.AKT...KEIETQIGRERLRLRRAFGIILRDYAWTRAVHFHGSEVESITHGPHEGRRFYG.YPPRAP.LA.YPS..V...DC-.ELV..GDGPVDEKLVSMLDYAVHGFD.NVIYVGSGDGRTLRLFRKKDRRRFASVDWILIDP.IAQPIEDvD.NVVVIRETIDTPRDLRR---FRRDGTTLLLWDVRSDRCDLDD.AAWEQVCLREDELGEDVASANGDWLDAALLKRRVPF.A-GTFK.CFTSILCYQPGAPEDMYELRSFL.AFNS-----RRWLGTPSLVTLAADG.IRQRIPIYHGRGKGRLLRTRLIQTLHVEPADALTHTS-APRADLFYLTNRRNPP--EKVFDVAARSEISTLWVGD-PLLSYDDYSMDRTEIMLRCSSDTHMVTDGLGFVLLLMLE--..G.E.VKNTVKFDPGWACNYAVVFRRRA-VAAVPDVWLCRFIGLRANSSSLRLREPISHATSDLIKSFGIDLSGHLYVTLITGRYLSDLRTWFRMILDWSSKGREEKMLALAHARAEVIEWKDEMEDGPWHRKEDLIAALNVFR..S..MAR----..--.---------aalhpyvdavvehlr........
W5QLY4_9REOV/2-634                 ..EPFAVLHLSAKLAPLVREGFIPYVDLDNIKTLNDLWIEIGKCSSDVYAVGRINRWTIRQLRAYRFIFVS.E.K.RT.I.TLK.D..IKITPDV--.PI...RCA..DG.LDL...KLLETTIGRKRLVLRKTFGDILRKYALSQSVHLHGSEAETLNMADPTIHHVKG.LPMIAP.NH.LNP..T...KPW.SDL..DDTETDEKLVSMLDYAMYSAQ.EVHYVGSGDGRTIRLFAKRDKKRFDRAKWVCYDP.IMTDIGL.T.NVIAVKHYVNTFRDMLPYLNTGDRVERLLLWDVSGDAAK-HD.RFWEAQRTEEDRRGESVAVSLTEYFALAIIKHRIPI.YEEKYR.CTTSWIVPQPGAVREMYEMRNII.LLNGFSRVNRAHIPQAGVMEIEADV.LREMVRNFHGAGRGRLLKKSLYESLHIHQVDGLEDSEDGARSDLFYLTNQRNVNSIQSIRRVLGNSTVSTLWVSRERVFEYDDFNFDRSALMLWHRGREHLLFDGNGAVLYLMWQHG..D.R.YRKDVNYDPSWAEHFAVLIREPQPWRPVPDLSLCRFISLRRVSTVIRIRG-DIHRKSDQVKRLGLDLSGHLFVTLISGAYLADLRWWFRMIIQWSKQRRQEKIDDLAKVNAEVVEWKEEKADEPWHRKEDLIAALIAAK..S..ITGD---..QH.IDGWIAEL-r......................
A0A077JHF2_9REOV/1-643             .m-SHAVIHLSGSLEHLAGKLFLPTWKIEQSKSVNDLWIENGRYFTDVYATGKLHDITLRQARGHGMLFVT.YgD.DS.T.RLR.D..AIAPRDIHI.PKgslDLN..GS.EVH...KSLERIIGSKRVKLRAEFGNILRKYAFKRCTTFHGSEVETVTKADPRRHKVYG.LPILCP.MI.DKIgvK...DRD.IFT..DDGACDEKLVSMLDYAVYSCD.VVYYVGCGDLRTLRIFQRRDPSRFARVHWVCIDP.IAPEYDS.R.NVSVYRDLIREPKDLLKYKRS--GREHLLLWDVRSDRGGISP.WEWEDRCLEEDALGEEVARNNKSWLHMAITKRRIPQ.YQNQIA.VYGSCLLPQPGAPQNMFELRNVIiHHDAPSLVDRRHLNEAQLMHVNVRK.SQEFIHKFHGLERGRRLKRSIIETLHIMRENGLTSQNRERRCDLFYLTNKLNETEQTKIESVLMDSQIATVWVGDVQPYGYDDFKMDRRLLMLRYSSEDRLVIDGNGFILLLMWQG-..D.E.SAKQARYDPFWAEQFCVICRYVDFDRNLPDISLCRFIGLRAESSLMRIRSDHLHERTDLVKKLGLDVSGHLYVTLVSGRYCVDLLWWFRMIMEWSSLSAKDKLRKMKERQVEVIEWKDDKADEPWHVREDLIAALRHAQ..T..AA-----..--.---------nlsstdvhrwimylh........
A0A0K1RH66_9REOV/3-642             ..EPHAVLYVTNELSHLVKSGYLPIWHLTGDESLNDLWLENGKYATDVYAYGDVSRWTIRQLRGHGFIFIS.T.H.KS.V.QLA.D..IIKTVDVRI.PR...EVA..KS.QDM...KMFENEIGRRRIRMRKGFGDALRSYAFKVAIEFHGSEAETLNEANPRLHRVYG.MPEAPP.LY.MEY..A...EIG.NKF..DDEPTDEKLVSMLDYIIYSAE.EIHYVGCGDLRTLMQFKKRSPGRFKRVLWHVYDP.IAPQCSD.T.NVIVHNIMVDSKKDILKHMNFLKRVERLFIWDVSSDRNQMDD.DEWESTRFAEDRLGEEIAYDMGGAFSSALIKHRIPA.MRDEYH.CISTYLLPQPGADTDMYELRNFM.RLKGYSHVDRHMHPDAAVMKVVSRD.VRRMVEMFHGKDRGRFLKKRIFEHLHIIRKNGLFYESDEPRADLFYLTNRCNMGLEPSIYEVMKKSTIATVWVGRTPLYDYDDYSLPRSTVMLNGSYRDIRVLDGNGAILFLMWKYP..D.L.IKKDLTYDPAWAMNFAVSLKEPVPDPPVPDISLCRFIGLRVESSVLRVRNPTLHETADELKRMGLDLSGHLYVTLMSGAYVTDLFWWFKMILEWSSQGKEQKIRDLKRSAAEVIEWKEQMAERPWHVRNDLIAALREYK..R..RMGTREG..AS.IDSWLELLR.......................
A0A346RV18_9REOV/3-647             .a-AHAVIHVARGFETQLANVYLPVIKLSGKEDLNHLWRIIGQYNTDVYVTGHLTRWTLRQLRAFCFIFVS.R.RgQI.V.NLM.D..GPAPQDISF.PN...NYP..KD.SLS...KDFEIKIGVDRMHLRKRFGNLLRGWTMKFATEFHGCEAETLMMADPRRHTIYG.LPPSPPaIG.IDS..A...VYE.PYL..NDLPTDEKLVSLLDYMLFSAD.VVYYVGSGDLRTVMKFRHKDLARFNRVKWICIDP.ISPVSPA.P.NIICYKSMITHPGQLRELKLDGDGLEHMLIWDVRSDKTGRTP.EEWEIVTQNEDAMGACIALYNRDWLALACVKYRIPAgSRAPVG.VFTSMLVPQPSAPTTMYELRSIM.RLEGFSHVDRSHIPTARDLVVEHSD.CIRLVQNFHGAARGKMLKKSLLEYLHISRVDGLEHRSGKPRVDLFYLTNKCNSNKKKKIHEVLALSNVATVWIGEETLTGYDDFKFSSQTLMLRYSSKERMVLDGNGVILYLMWKGA..F.KeEPRKIIYDPSWAMKFGVVMRRSYGEDIVPDVSLCRFVGLRRLSTQYRLNTDFIHRRADVLKRLGLDVSGHLFVALVSGAYCFDMHWWVKMIKEWSVLSERDKLMSLANAKADIIEWREENANAPWHRPEDLAAALSLVS.sL..QIPVVSN..TD.IAKWLEILR.......................
C8TE61_EHDV1/3-642                 ..EPHAVIYVTEELTHLIKESYLPVWEIRGDETLNELWLTNGKYSSDIYAHGKIETWSYRQLRGHGFIFVS.T.R.KT.V.QLS.D..VLMNVDVRI.PK...DII..KG.VDV...KAFETIIGRRRLKLRKMFGDVLRSYAFRKAIILHGSEAETLNDANPRLHKVYG.LPKEPP.MY.HEG..L...CAQ.GPF..LDEPTDEKLVSMLDYAIYSCE.EVHYVGSGDGRTVMCFAKRSPERFHRIVWHLYDP.IAVDLKY.N.NVYVHRMFVDGKRDIIRNVNLLKRVERLFIWDVSTDRGDMSD.REWERHRFAEDRLGEEIAMSTSGLFSMAIIKHRIPR.FMEQYH.ITSTYLFPQPGAPSDMYEVRNVM.RLRGYSHVDRTRHQDAQVHTIVQKD.VCKLVEWYHGREKGKRLKKMLFEYLHIMRENGLYAENEEPRADLFYLTNRCNYDMWREQKRVLRVSQIATMWVGGDQLFDYDDYSVPRALLMLECSHADVRVLDGNGAVLFLIWRYP..D.M.YKRGLNYDPSWAMKFVVTMKEPVPDPPVPDISLCRFIGLRVESSLMRVRNPRVHQVNDELKRMGLDVSGHLYVTLLSGAYATDLLWWFKMILEWSSQNKEEKIRQLKASKAEVIEWKDEMAERPWHVRNDLIAALREFK..F..KIQKRWD..AP.VESWLDLL-q......................
G8DP06_9REOV/1-643                 .m-SHAVIHLSKSLEHLASKLFLPTWKIEGDKTVNELWIENGRYFTDVYAIGRLHALTIRQARGHSIIFVV.YgD.DS.T.RLK.D..AIAPRDIHI.PK...GSLdlRGpEVH...KMLERIIGAKRVRLRAEFGNVLRKYAFKNCITFHGSEIETVTKSDPRKHKVYG.LPELCP.MI.TRF..G...VMD.NEIyqSDAACDEKLVSMLDYAIYSCD.VVYYVGCGDLRTLRIFQKRDPQRFSRVKWVCIDP.IAPNYGS.S.NVKVYPCVFKEPKDLLKFKQTGK--EHMLIWDVRSDKGDASP.WEWEDICREQDALGEETARKNKSWLHMAIVKRRIPQ.YQEQLT.LYGSCVLPQPGAPQNMYELRNVIiHHDAPSHIDRKHLQEAQLFYVNVKK.AREMVAKFHGLDRGRKLKRSIIETLHIMRDNGLTSQHQEKRCDLFYLTNKRNEDYQMQISQILRESEIATLWVGDTKPYGYDDFKMDRRSLMLRYSAEDRLVIDGNGFMLLLMWQ-G..E.I.DARAIRYDPFWAEQFCVIVKYTDFERNLPDISLCRFIGLRAESSLMRIRSDHLHERTDLVKRLGLDVSGHLYVTLVSGRYCVDLLWWFRMIMEWSSMNAKDKLQRMREKNVEVIEWKDDKVDEPWHVREDLIAALRHAK..E..-MANLSS..MD.VHRW-----ivylh..................
C5IWW0_9REOV/3-642                 ..EPHAVLYVTNELSHIVKSGFLPIWRLTGDESLNDLWLENGKYATDVYAYGDVSKWTIRQLRGHGFIFVS.T.H.KN.I.QLA.D..IIKTVDVRI.PR...EVA..KS.QDM...KAFENEIGRRRIRMRKGFGDALRNYAFKMAIEFHGSEAETLNDANPRLHKVYG.MPEIPP.LY.MEY..A...EIG.TRF..DDEPTDEKLVSMLDYIVYSAE.EVHYVGCGDLRTLMQFKKRSPGRFRRVLWHVYDP.IAPESSD.P.NVIVHNVMVDSKKDILKHMNFLKRVERLFIWDVSSDRSQMDD.DEWESTRFAEDRLGEEIAYEMGGAFSSALIKHRIPN.SRDEYH.CISTYLLPQPGADADMYELRNFM.RLKGYSHVDRHMHPDASVMKVVSRD.VRKMVELYHGRDRGRFLKKRLFEHLHIVRKNGLLHESDEPRADLFYLTNRCNMGLEPSIYEVMKKSVIATAWVGRAPLYDYDDYALPRSTVMLNGSYRDIRVLDGNGAILFLMWKYP..D.I.VKKDLTYDPAWAMNFAVSLKEPIPDPPVPDISLCRFIGLRVESSVLRVRNPTLHETADELKRMGLDLSGHLYVTLMSGAYVTDLFWWFKMILDWSAQSKEQKLRDLKRSAAEVIEWKEQMAERPWHVRNDLIAALREYK..R..KMGMREG..AS.IDSWLELLR.......................
A0A0X8GWG9_9REOV/2-637             ..EPCAVLHVSGDIVPLIEKGFLPIFDVNRISTLNDLWIERGKFGTECYCYGTLTKWTIRQLRGHRFIFVS.T.K.KR.I.HLK.D..TIITPDVVI.SQ...QVL..-S.GGL...KELETVIGFKRIGLRKNFGDQLRKYALLSCRFLNGSEAETLNVAEPNVHKVRG.LTMEPP.TH.LNL..-...-LG.SYE..NDGPTDEKLVSMIDYITYSAD.QIYYVGCGDLRTLKLFAKRDKRRFNRVRWFCFDP.IAPESFA.E.NVLVRKTKIESYRDLKKYMDD-GTVERVLIWDVSGDGKK-GT.IEWEQQRASEDRMGEQVAKGLAKFFSFAVIKHRIPK.DNEVYS.CYSSLIVPQPGAAQDMYECRNII.KLEGFSKVDRTHLGEARIHYVSPKD.LRLLIHRFHGFGRGRKLKKSIFEYLHIERVNGL-DSLDEPRADLFYLTNHRNATRAEDIRRVVEQSTISTLWVGKRPLYDYPDFRYPRCDAMLRFSNITNRVFDGNGALLYLMWKYP..E.K.FSKKVNYDPAWAENYCVILKEDIPRIPVPELSLCRFIGLRTVSTMMRVQTNSVHQISDKVKKMGLDLSGHLFIALMSDSYISDIMWWFDMILNWSVLNREEKKRKLFEMNAEVIEWKEDRANEPWHIKPDLIAALMEFS..RftSVMMTDE..AC.VTKWILYLR.......................
A0A0K1TPI9_9REOV/3-641             ..EPHAVIYVTKELLPLIENSYLPIWYLSGKESINELWLENGKFAADVYAYGLINQWSYRQLRGHGFIFVS.T.Q.KK.I.QLS.D..VLMDVDVRV.SK...KIA..AE.RDV...KAFESEIGRRRLRMRKNFGDILRDYAFRNAVVFHGSEAETLNDASPRLHKVCG.LPEQPP.YY.DDY..T...ARF.EPF..PDSATDEKLVSMLDYALYSAE.EVHYVGAGDLRTLFKFKQRSEGRFKRVIWHVYDT.ILPTHAE.S.NVYNHRHYVDRPKDMLQYMNMTKRVERILIWDVSSDRGEQTD.DEWDRTRFAEDRLGEEIAMEMSGTFSMAIIKHRIPF.-REQYN.CISSFLIPQPAAPKTMYELRNVM.LLRGYSHVDRKHIPQAKIMSVQSHL.AQKMVELYHGVDRGKRLKKMLFEWLHIEHVNGLYYEGEEARADLFYLTNSLNRRDWGRIKKVLRTSMIGTLWCGRTQLYDYDDFVVERPKAMLELSYRDVRVMDGNGAILFLIWKHS..E.I.YKRGLNYDPAWAQNFIVTLREPIPNPPVPDISLCRFIGLRVESSLLRVRNPTMHEVADELKKLGLDLSGHLYVTLMSGSYVADLMWWFEMILKWSSLGAEEKKAQLRSSGAEVIEWKDQMADRPWHVKNDLIAALREYQ..Y..KMARREP..VQ.VQSWIDLLR.......................
H9ZXR5_9REOV/3-642                 ..EPHAVLYVTSELEPLAELAFLPKWELSGDESLNELWLKNGCFGQDVYCYGRIAKWSARQLRAHGFIFIS.T.K.KS.I.RLK.D..CMMPVDIRI.PL...DFL..IK.YDV...KKFETFIGRKRISLRKSFGNILRRYALSKANYFHGSEAETLNIANPRIHHVKG.MPRDPP.TH.YSW..H...NKI.MPD..DDEGTDEKLVSMLDYMMYSAE.EVHYIGSGDLRTLYMFKKRNPRRFNQATWHVYDP.IAETTEM.S.NVIVHKEMVTHHGQIMANINVLKRVERIFIWDVSGDRGPMNS.EEWEEKRDREDRKGESMALELEGAFSLALIKHRVPQ.HMDKYW.CTTSALIPQPSAPKGMYELRNII.RLNGYSYVNRSHIPPHAMVRLNTRD.MQAMCERFHVSGKGKKLKKLIFEFLHIEREDGLAADLQVPRADLFYLTCAENRTRWEDVKTTVMASQISTLWVGKNRLFDYNDFRVERSEVMLTFSSREVRVFDGNGAVLYLMWKYP..Y.M.FDKTLNYDPAWAANFAVMMKEPIPQPAVPDLSLCRFIGLRIASSIVRLNNPGIHAVPDELKAIGLDLSGHLFMTLVSGAYLADLRWWLAMILEWSSQDGEEKKRDIERAHAEVIEWKEDMAFKPWHVRNDLIAALREYT..K..YCTEREK..PS.LTGWIMH--lq.....................
Q2Q1E1_9REOV/3-646                 .t-THAVIYLAKGFGPQLKDVYLPILKLSGRESVNDLWKWVGQYNTDIYATGPLQKWSIRQLRGLGFIFVG.R.R.GQsI.LTR.D..GTAPLDIIF.PQ...NYP..ED.STS...KSFETKIGIDRVYLRKKFGDILRNYALKFAVEFHGSEAETLMVTDPKRHKVFG.LPELPP.AL.GIQ..T...DFN.APY.sDDNHTDEKLVSLLDYFVYSVD.IMFYIGCGNLRTLLKFRHKDETRFNRVTWICIDP.IVPESPA.P.NIICYPNMITHGGQLRALKKSAENFEYGLIWDVRSDRGSLSG.DEWDSITRKEDELGVYIALANRDWIHMACIKFRIPT.SEQSFN.VYTSILVPQPSAPITMFELRNIL.VLDGFSTVDRSHIPKARTLEIKHVD.CCSLVRNFHGNSRGRKLKKAILEYLHITRSNGLEHKGTLPRVDLFYLTNKRNREKMQEIGEVIEKSVLSTVWIGPELRSGYDDFTYPTQTLMIKYCKKEKMVIDGNGYILFLIWKGV.lG.D.EGFKVSYDPSWAAKFGIVCLRRSAVDMVPDVSLCRFVGLRRHSTMLRLNSDQVHRRPDILKRLGLDVSGHLFVSLTVGGFCFDLLWWIKMIKEWSILPEAQKLFAIAEAHAEIVEWREENANEPWHRPEDLRAALSLIS.tM..DMPLLRK..SD.YTRWMDMLR.......................
A0A1V0CK02_9REOV/3-642             ..EPHAVLYVTNELSHIVKSGFLPIWRLTGDESLNDLWLENGKYATDVYAYGDVSKWTIRQLRGHGFIFIS.T.H.KN.I.QLA.D..IIKTVDVRI.PR...EVA..KS.QDM...KAFENEIGRRRIRMRKGFGDALRNYAFKMAIEFHGSEAETLNDANPRLHKVYG.MPEIPP.LY.MEY..A...EIG.ARF..DDEPTDEKLVSMLDYIVYSAE.EVHYVGCGDLRTLMQFKKRSPGRFRRVLWHVYDP.IAPESSD.P.NVIVHNVMVDSKKDILKHMNFLKRVERLFIWDVSSDRSQMDE.DEWESTRFAEDRLGEEIAYEMGGAFSSALIKHRIPN.SRDEYH.CISTYLLPQPGADADMYELRNFM.RLKGYSHVDRHMHPDASVMKVVSRD.VRKMVELFHGRDRGRFLKKRLFEHLHIVRKNGLLHESDEPRADLFYLTNRCNMGLEPSIYEVMKKSVIATAWVGRAPLYDYDDYALPRSTVMLNGSYRDIRILDGNGAILFLMWKYP..D.I.VKKDLTYDPAWAMNFAVSLKEPIPDPPVPDISLCRFIGLRVESSVLRVRNPTLHETADELKRMGLDLSGHLYVTLMSGAYVTDLFWWFKMILDWSAQSKEQKLRDLKRSAAEVIEWKEQMAERPWHVRNDLIAALREYK..R..KMGMREG..AS.IDSWLELLR.......................
U3RA82_9REOV/3-642                 ..EPHAVLFVTKELVPLLKNSFLPVWELKGNETLNELWMQNGKFASDVYCYGNVSPWTYRQLRAHGFIFIS.T.K.KN.V.TLK.D..GALNVDIRI.PT...EVF..AS.NDL...KQLETYVGKKRLTLRKQFGNILRRFALAKASVLHGSEAETLNVANPRVHKVRG.WVRCPP.IY.GEF..A...IAP.WEV..SDDATDEKLVSMLDYFIYSAE.EVHYVGCGDLRTLHKYAQRNKKRFSNILWHCYDP.IAPADPN.V.NVRVHRTIVKSGSQLMEQMNMLKRVERVLIWDVSSDRGNKNV.VEWEQQRSEEDRLGESIAKELEGTFSMALIKHRVPQ.LVDEYW.CSTSILIPQPMAPKDMFELRNVM.KLSGFSYVKRDHIEKWREMKIDVRR.AQNFCVKYHRTNTGRKLKKMLFEYLHIEQEDGLRAKLDEARADLFYLSNRRNQAFWHCIRDVLKVTQIGTLWVGKRRLFDYDDFVVSRSTVMLQCSYRDVRVFDGNAAVLYLLWKYP..E.M.FDKTWSYDPGWAQNFAVIIHDSCPEPPVPDVSLCRFIGLRLQSSMIRLNSPSAHEMADHLKKIGLDVSGHMMMTLMSDAHVADLYWWIRMILEWSSQDAAGKLRDLHRSKADVIEWKEEMEGKPWHLKNDLISALIEYG..R..FCREGER..ES.INSWIEHLR.......................
#=GC SS_cons                       ..----EEEE-CCCHHHHTTSSS-EEE--ST--HHHHHHHHTT-SS-EEEES--TSS-HHHHHCTTEEEEE.S.S.SE.E.E-S.S..SEEE-SEE-.-S...TTS..TT.T-H...HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-SEE-S--HHHHHT--TTT-EEEE.------.-B.SST..-...---.---..---B-S-HHHHHHHHH-SS-S.EEEEET-TTSHHHHHHHHHSHHHHHTSEEEEE-T.T------.T.TEEEE----SSTHHHHTTS-TTS---EEEEE-----------.---TCHHHHHHHHHHHHHHHCBTTECEEEEEEE--S.S-SEEE.EEESEEE--TT--TT--EEEEEE.E-SS--SS--TTS---EEEEEEHHH.HHHHHHHH--TT-BHHHHHHHHHHHHSEEB-TTT---SS-EEE-S-TTBGGGTT-HHHHHHHHCC-SEEEEE---S--TT--B----HHHHHHHH-BSSEEEEEHHHHHHHHHHHST..T.T.S-SS----HHHHTTEEEEEE----SS----TTT---TTHHHHHHHHHHHS----------------HHHHHHHHHHHS-----HHHHHHHHHTTSSS-TCCCTTTTTTTT---S-------------HHHHHHHHHHHH..H..C-SSSS-..ST.THHHHTTTS.......................
#=GC seq_cons                      ..EPHAVlYlopcLppllccuFLPlWcLsGpEoLN-LWlpNG+auoDVYAhGslppWolRQLRGHGFIFlS.s.+.cp.l.pLp.D..shhssDlpI.sp...phh..ps.tsh...KphETpIG++Rl+LRKsFGshLRpYAhppAs.FHGSEAETLshAsP+hH+VaG.LPctPP.hh.hph..s...pht.s.h..sDpsTDEKLVSMLDYhlYSA-.pVaYVGsGDLRTLhpFp+RsPpRFpRlpWhshDP.Iuspsst.s.NVhla+phVcs.cDlhphhphhcclE+lLIWDVpoDRushss.pEWEppphpEDRLGEplAhphpuhhuhAlIK+RIPp.hp-pap.shoShLlPQPGAPpsMYELRNlh.+LcGaS+V-RpHlPpuphhplsscs.sRchVcpaHGpcRGRhLK+plaEaLHIpRpsGLtpcsppsRADLFYLTN+pNtshhppItcVlcpSpIuTlWVGcp.ha-YDDashsRsplMLchSsc-phVlDGNGhlLaLMW+as..p.h.hp+slsYDPuWAtsFuVlh+cshspsPVPDlSLCRFIGLRspSShLRlpssplHchsDhLK+hGLDlSGHLYVTLhSGuYlsDLhWWF+MIL-WSspsc-pKlpsLpcupAEVIEWK--hAscPWHl+pDLIAAL+tap..h..hh..........lttWh...........................
//
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