#=GF ID Orf78
#=GF AC PF06024.15
#=GF DE Orf78 (ac78)
#=GF PI DUF912;
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_8809 (release 9.0)
#=GF GA 28.00 28.00;
#=GF TC 28.00 28.20;
#=GF NC 27.90 27.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 23698311
#=GF RT The Autographa californica multiple nucleopolyhedrovirus Orf78
#=GF RT is essential for budded virus production and general occlusion
#=GF RT body formation.
#=GF RA Tao XY, Choi JY, Kim WJ, Lee JH, Liu Q, Kim SE, An SB, Lee SH,
#=GF RA Woo SD, Jin BR, Je YH;
#=GF RL J Virol. 2013;87:8441-8450.
#=GF RN [2]
#=GF RM 25087880
#=GF RT Disruption of the baculovirus core gene ac78 results in
#=GF RT decreased production of multiple nucleocapsid-enveloped
#=GF RT occlusion-derived virions and the failure of primary infection
#=GF RT in vivo.
#=GF RA Li SN, Wang JY, Yuan MJ, Yang K;
#=GF RL Virus Res. 2014;191:70-82.
#=GF DR INTERPRO; IPR009261;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Family members include Autographa californica nuclear
#=GF CC polyhedrosis virus (AcMNPV), AC78 or Orf78. AC78 is a late gene
#=GF CC in the viral life cycle and encodes an envelope structural
#=GF CC protein that plays an essential role in embedding the
#=GF CC occlusion-derived virus (ODV) in the occlusion body [1].
#=GF CC Although AC78 is not essential for budding virus formation or
#=GF CC nucleocapsid assembly and ODV formation, number are
#=GF CC significantly reduced if the gene is knocked-out [2].
#=GF SQ 21
#=GS A0A6A5B8U0_NAEFO/18-108 AC A0A6A5B8U0.1
#=GS Y078_NPVOP/3-100 AC O10331.1
#=GS A9YMW7_9BBAC/5-101 AC A9YMW7.1
#=GS A0A063BVC7_USTVR/254-344 AC A0A063BVC7.1
#=GS A0A1S5YE07_9BBAC/4-97 AC A0A1S5YE07.1
#=GS AC78_NPVAC/3-104 AC Q06693.1
#=GS Q8B9H6_NPVR1/3-104 AC Q8B9H6.1
#=GS A0A162GUT3_9ABAC/3-106 AC A0A162GUT3.1
#=GS Q2NNZ9_NPVHC/3-102 AC Q2NNZ9.1
#=GS A0A162GW05_9BBAC/5-106 AC A0A162GW05.1
#=GS C3VNX3_NPVBM/3-105 AC C3VNX3.1
#=GS Q71AA7_9ABAC/3-112 AC Q71AA7.1
#=GS Q9J856_9ABAC/3-126 AC Q9J856.1
#=GS A0A183MAX1_9TREM/4-80 AC A0A183MAX1.1
#=GS A0A0B5A1C8_9ABAC/3-122 AC A0A0B5A1C8.1
#=GS A0A343RRJ8_NPVMN/3-114 AC A0A343RRJ8.1
#=GS A0A1D8QLD4_GVTN/5-105 AC A0A1D8QLD4.1
#=GS D2J4Q6_9BBAC/8-94 AC D2J4Q6.1
#=GS Q6JPC5_NPVNC/1-92 AC Q6JPC5.1
#=GS A0A288Q7F2_9ABAC/3-107 AC A0A288Q7F2.1
#=GS A0A024WFD9_PLAFA/4-94 AC A0A024WFD9.1
A0A6A5B8U0_NAEFO/18-108 .......aherten------------.--------------..............NYNNNNNLVYTIYATNSTTHHNVTASSSQt...............dsGTSTERVVLVCLLLLVVSVLLVVMVFAIYYWMKKRRER.KEQM...------eatqqlpqsq...
Y078_NPVOP/3-100 ..............LDVPYYRLGAHE.RVEYIPLKLALND-..............DAPPPAAHEYAE-------ARAAGGEAAP..................PAEQWSAGVIVLIGLVAFVALFLLLYVIYYFVILRDQP.QYSD...------didndppfa....
A9YMW7_9BBAC/5-101 ..............LDIPFDRLTVPD.VVDAIPLKLAYSK-..............ESDDNNKPPVVPSAQAVYGSREEKSAQSD..................-------MSNVWFIALACITVLVVIMLISYYIVSVLRT.NNA-...------plrdydddd....
A0A063BVC7_USTVR/254-344 platsslltqplqq------------.--------------..............-QQQQQQLQQLQQQQKQQQQQQQQQQQQQ..................QQQQQQQQHVVVVVVVVVVVVVVVVVVVVVVVVVEQQAaQSQV...QQ----ppcv.........
A0A1S5YE07_9BBAC/4-97 ..............LDIPLERWSVPD.VVDAIPLKLAYTS-..............-----SKDTTPPSAQAVYNSKDDDAVSPP..................---PATTDTNVWFIAFACITVLAIVLLISYYIVSALRI.----...------ddtaeprdld...
AC78_NPVAC/3-104 ..............LDVPYYRLGNHE.KVEYIPLKLALND-..............--DTASEPQQFSEPVHKMPINDMVGYDNT..................-TSNVSAGIIILISVVAFIALFLLLYVIYYFVILREQQ.QYSD...------sidtdspfv....
Q8B9H6_NPVR1/3-104 ..............LDVPYYRLGNHE.KVEYIPLKLALND-..............--DIASEPQQFSEPVHKMPINDMVGYDNT..................-TSNVSAGIIILISVVAFIALFLLLYVIYYFVILREQQ.QYSD...------sidtdspfv....
A0A162GUT3_9ABAC/3-106 .............f-NLPYKNFTINN.SVEYIPLKLVLNK-..............DSSNDTKMSSNDTSNRTLLMNESDNLYYE..................KTILKLKFDILILYCVIVVCVTLVLYFILYYVILRERR.NNFV...------girqnnly.....
Q2NNZ9_NPVHC/3-102 ..............LDVPYYRLGNHE.RVEYIPLKLALND-..............DAPPDNSHEYADSM----EHKMDGEMQTR..................-ANQMSTGLIMFISLIAFVALFLLLYVIYYFVILREQP.QYSNdidNDPSF-l............
A0A162GW05_9BBAC/5-106 ..............LEIPFERFNISG.VVEAIPLKLAYSK-..............--ESDNAPDSKSPVVPSAQAVYGKNEEK-..................-XSMQSDSSNVWFIAMACISVLVVILLISYYIVNVLRT.N---...------ggsykdfsedeey
C3VNX3_NPVBM/3-105 ..............LDVPYYRLGNHE.KVEYIPLKLALND-..............--DITSEPQQFSEPVYKMPIDDMMVGYNN..................TASNVSAGIIILISVVAFIALFLLLYVIYYFVILREQQ.QYSD...------sidtdspfv....
Q71AA7_9ABAC/3-112 ..............LDIPYERLSPTL.TVKYIPLKLALNDIp...........dtSNGDTANSKNSNDSAASAPKVSITVPEKRny.............dtaVANPKQMYDVLVLGMLTVFCILVLLYAIYYFVILRDRQ.KPTT...------epril........
Q9J856_9ABAC/3-126 ..............LDVPYERLGTAT.KVDYIPLKLALTDLpennisssssssvdDYDNNDKNKTLSTAKNQRPKVDIDLTDRNlqlr..........qpsaDLSKQQFYNSLVLGLLTFFCVLVLLYAIFYFVILRDRQ.KSIV...-KPSYM.............
A0A183MAX1_9TREM/4-80 ...rrehllesnvt------------.--------------..............----------K-ATNNNNNHSNYLQNDEI..................EFEMFHLTNNLLIILLSVLCIIIILLLLIYIVYRRLRH.HQHH...HDSQY-f............
A0A0B5A1C8_9ABAC/3-122 ..............LEVPYERMSLNQkRVEYIPLKLAVNDIdengyk..kpkqktVN--------------DADDNEIKKIRTSptllsndiggntnyiayaNTEKTGVLNVVLLALLSIFCVLVILYAIYYFVIIRERE.KRIV...KPPYF-i............
A0A343RRJ8_NPVMN/3-114 ..............LDVPYERLGLNS.KIEYIPLKLAIEDV..............ENVTTTKNDIANKTNNSNFVKQTPNSSPEsfyd.........ngsggDIQYNNMLHFITICMLTVFCVIVLLYAVYYFIILRDRH.NNAL...N-----pqllf........
A0A1D8QLD4_GVTN/5-105 ..............LEIPFERFTIPD.VVDAIPLKLAYSK-..............ETDDDMKHN---NKSPVVPSAQAVYGNRD..................EKSTQSDTTNVWFIALACITVLVVIMLISYYIVSVLRR.NNAP...------lrdyeddd.....
D2J4Q6_9BBAC/8-94 ..........isll---------RNT.YVEPIALKLAHIN-..............NNSNNNNNHDQNES------NTVVASNE-..................----DNAKPAMWLIIASGVFILIVVLLVSYFIVSRING.RYRN...------dfdeeny......
Q6JPC5_NPVNC/1-92 .............m-NIDYNKISDDV.SVKTYPLKVNIPET..............IATKNLSPRETTDSSTDDATSNNDTNTTN..................--FVWQLLSICIVGLLIIVGIIVLLYFL----------.----...------ssrddgqaeii..
A0A288Q7F2_9ABAC/3-107 ..............LDLPYYRLGNHE.KVEYIPLKLALND-..............DISNEQQQQQHQKD--TFVHDESGANGGViiy............nagAEPAMPVAFIILISLAAFVALFLLLYIIYYYVVLREQQ.QQYS...------ddnfd........
A0A024WFD9_PLAFA/4-94 ...........pdf------------.--QAIPLK-AQ-EI..............VTQGTKAADAKTAEVSSRIAADITTKQTT.................aINSTYASYEITIIASIVAIVVIVLIMVIIYL-ILRYRR.KTKM..kKKLQ--yi...........
#=GC seq_cons ..............L-lPa.Rhs.pp.hV-hIPLKLAhsc.................ssssp.pthsps.tshstsphsstpsp...................tp.hsshpllllslluhlsllllLalIhYalllRppp.p.ts.........s.p..........
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