#=GF ID   PASD1_N
#=GF AC   PF30269.1
#=GF DE   Circadian clock protein PASD1 N-terminal domain
#=GF AU   Morveli N;0000-0003-2496-881X
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   TED:Q8IV76_TED02
#=GF GA   27.00 27.00;
#=GF TC   27.10 27.70;
#=GF NC   26.50 21.30;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -E 1000 -Z 90746521 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   25936801
#=GF RT   Cancer/testis antigen PASD1 silences the circadian clock.
#=GF RA   Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM,
#=GF RA   Banham AH, Partch CL;
#=GF RL   Mol Cell. 2015;58:743-754.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents a conserved N-terminal domain found in
#=GF CC   PASD1 (PAS domain-containing protein 1) from vertebrates. This
#=GF CC   domain contains a PAS-like fold. PASD1 functions as a nuclear
#=GF CC   repressor of the CLOCK-BMAL1 heterodimer, inhibiting
#=GF CC   transcriptional activation of core clock components [1]. PASD1
#=GF CC   is normally testis-specific but is also expressed in various
#=GF CC   cancers including melanoma, lung cancer and diffuse large B-cell
#=GF CC   lymphoma, and is classified as a cancer/testis antigen (CT63).
#=GF CC   Mutagenesis of residues within this region reduces inhibition of
#=GF CC   CLOCK-BMAL1 activity [1].
#=GF SQ   17
#=GS A0A2K6TEI5_SAIBB/469-513  AC A0A2K6TEI5.1
#=GS A0A8C9HFT0_9PRIM/471-521  AC A0A8C9HFT0.1
#=GS A0A2K5WV84_MACFA/474-519  AC A0A2K5WV84.2
#=GS A0A0D9R410_CHLSB/487-532  AC A0A0D9R410.1
#=GS G1RTN3_NOMLE/479-524      AC G1RTN3.2
#=GS A0A2R9CDN9_PANPA/504-541  AC A0A2R9CDN9.1
#=GS PASD1_HUMAN/481-526       AC Q8IV76.1
#=GS F7GC03_MACMU/473-518      AC F7GC03.2
#=GS A0A6J3GQF2_SAPAP/481-526  AC A0A6J3GQF2.1
#=GS A0A096NYQ7_PAPAN/479-524  AC A0A096NYQ7.3
#=GS A0A8D2ESI6_THEGE/479-524  AC A0A8D2ESI6.1
#=GS G3QST1_GORGO/496-534      AC G3QST1.2
#=GS A0A2K5IWR9_COLAP/419-464  AC A0A2K5IWR9.1
#=GS H2PX29_PONAB/485-530      AC H2PX29.2
#=GS A0A2K5RDV2_CEBIM/478-523  AC A0A2K5RDV2.1
#=GS H2QZ83_PANTR/500-537      AC H2QZ83.2
#=GS A0A2K5C1F6_AOTNA/473-516  AC A0A2K5C1F6.1
A0A2K6TEI5_SAIBB/469-513             QLAQQEQRLKEQQQQLRKRLQHLREQRK..VHEQK.....KIQEKK-LQEHKM.
A0A8C9HFT0_9PRIM/471-521             QLTQQEQHLKEQQRQLRKQLQQLREQRK..VQKQKkmqekKMQEKKKLQERK-k
A0A2K5WV84_MACFA/474-519             QLAQQEQRLKEQQRQLRKQLQQLREQRK..VQKQK.....KMQEKKLLQEQKM.
A0A0D9R410_CHLSB/487-532             QLAQQEQRLKERQRQLRKHLQQLREQRK..VQKQK.....KMQAKKKLQEQKM.
G1RTN3_NOMLE/479-524                 QLAQQEERLKEQQRQLRKQLQQLREQRR..VQKQK.....KMQEKKKLQEQKM.
A0A2R9CDN9_PANPA/504-541             --------LREQQRQLRGQLQQLREQRK..VQKQK.....KMQEKKQLQEQKM.
PASD1_HUMAN/481-526                  QLVQQEQHLKEQQRQLREQLQQLREQRK..VQKQK.....KMQEKKKLQEQKM.
F7GC03_MACMU/473-518                 QLAQQEQRLKEQQRQLRKQLQQLREQRK..VQKQK.....KMQEKKLLQEQKM.
A0A6J3GQF2_SAPAP/481-526             QLAQQEQRLKEQQRQLRKRLQQLREQRK..VQKQK.....KMQEKKKLQEHKM.
A0A096NYQ7_PAPAN/479-524             QLAQQEQRLKEQQRQLRKQLQQLREQRK..VQKQK.....KMQEKKLLQEQKM.
A0A8D2ESI6_THEGE/479-524             QLAQQEQRLKEQQRQLRKQLQQLREQRK..VQKQK.....KMQEKKLLQEQKM.
G3QST1_GORGO/496-534                 --------LREQQRQLREQLQQLREQRKkkLQEQ-.....KMQEKKKLQEQR-q
A0A2K5IWR9_COLAP/419-464             QLAQQEQHLKEQQRQLRKQLQQLREQRK..VQKQK.....MMQEKKKLQEQKM.
H2PX29_PONAB/485-530                 QLAQQEQHLKEQQRQLRKQLQQLREQRK..VQKQK.....KMQEKKKLQEQKM.
A0A2K5RDV2_CEBIM/478-523             QLAQQEQRLKEQQRQLRKRLQQLREQRK..VQKQK.....KMQEKKKLQEHKM.
H2QZ83_PANTR/500-537                 --------LREQQRQLRGQLQQLREQRK..VQKQK.....KMQEKKQLQEQKM.
A0A2K5C1F6_AOTNA/473-516             QLAQEEQRLKEQLQQLREQ-RKMQEKKK..LQEQ-.....KMQEKKKLQEHKM.
#=GC seq_cons                        QLAQQEQ+LKEQQRQLRKQLQQLREQRK..VQKQK.....KMQEKKpLQEQKM.
//