GenomeNet

Database: Pfam
Entry: PBP-Tp47_a
LinkDB: PBP-Tp47_a
Original site: PBP-Tp47_a 
#=GF ID   PBP-Tp47_a
#=GF AC   PF14889.8
#=GF DE   Penicillin-binding protein Tp47 domain a
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   CATH:1o75_A_03
#=GF GA   25.00 25.00;
#=GF TC   26.10 30.50;
#=GF NC   23.50 23.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12196546
#=GF RT   Crystal structure of the 47-kDa lipoprotein of Treponema
#=GF RT   pallidum reveals a novel penicillin-binding protein.
#=GF RA   Deka RK, Machius M, Norgard MV, Tomchick DR;
#=GF RL   J Biol Chem. 2002;277:41857-41864.
#=GF DR   INTERPRO; IPR029221;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the first domain in this unusual penicillin-binding
#=GF CC   protein PBP), Tp47 is mainly composed of beta-strands and is
#=GF CC   sequentially non-contiguous. The first three domains in Tp47
#=GF CC   interact with each other through intimate domain-domain
#=GF CC   interfaces. Domain A contacts domain B through its N-terminal
#=GF CC   segment. Domain A also interacts tightly with domain C, Tp47 is
#=GF CC   unusual in that it displays beta-lactamase activity, and thus it
#=GF CC   does not fit the classical structural and mechanistic paradigms
#=GF CC   for PBPs, and thus Tp47 appears to represent a new class of PBP
#=GF CC   [1]. 
#=GF SQ   27
#=GS A0A0D0RGI1_9FIRM/618-779  AC A0A0D0RGI1.1
#=GS A0A3E2XKM3_9FIRM/726-883  AC A0A3E2XKM3.1
#=GS A0A416BIV9_9FIRM/78-239   AC A0A416BIV9.1
#=GS R7ISI0_9FIRM/153-312      AC R7ISI0.1
#=GS R6AYB7_9FIRM/142-277      AC R6AYB7.1
#=GS R5UYY2_9FIRM/33-194       AC R5UYY2.1
#=GS A0A174A0X0_CLOVE/47-240   AC A0A174A0X0.1
#=GS R6BNT1_9FIRM/35-217       AC R6BNT1.1
#=GS R6GB89_9FIRM/1-50         AC R6GB89.1
#=GS R7I128_9CLOT/42-207       AC R7I128.1
#=GS R5U519_9FIRM/578-743      AC R5U519.1
#=GS U2KAE3_9FIRM/47-210       AC U2KAE3.1
#=GS TA47_TREPA/24-220         AC P29723.2
#=GS TA47_TREPA/24-220         DR PDB; 1O75 B; 7-201;
#=GS TA47_TREPA/24-220         DR PDB; 1O75 A; 7-201;
#=GS A0A373LFV6_9FIRM/1-41     AC A0A373LFV6.1
#=GS A0A1G5CWJ6_9FIRM/125-286  AC A0A1G5CWJ6.1
#=GS D4M2N0_9FIRM/649-809      AC D4M2N0.1
#=GS C4Z2X1_EUBE2/34-195       AC C4Z2X1.1
#=GS A0A2U1B742_9FIRM/817-969  AC A0A2U1B742.1
#=GS R5S9W5_9CLOT/32-196       AC R5S9W5.1
#=GS R6V2K1_9FIRM/654-820      AC R6V2K1.1
#=GS A0A174ANB4_9FIRM/534-702  AC A0A174ANB4.1
#=GS D4MVX7_ANAHA/43-213       AC D4MVX7.1
#=GS R7JW13_9FIRM/675-825      AC R7JW13.1
#=GS R7NKY5_9FIRM/39-208       AC R7NKY5.1
#=GS R7FCJ1_9FIRM/35-197       AC R7FCJ1.1
#=GS R6LRK9_9FIRM/665-830      AC R6LRK9.1
#=GS R7C694_9CLOT/40-207       AC R7C694.1
A0A0D0RGI1_9FIRM/618-779             ..................pd--GYKYVYAGLTWDEYWKSEGVYA...AGNA...--SSSSERDSRDEADKGGFDVVTRATKNHGLHRGSFQSIATIYDTDG....NSYKVLSWSKDG.............................KTINLVDGS..SIG..WS...KGT.....IT..KSDG...TTSTMKYYEVSGIKYVPVKVKEADYEEFAKKYQVTENAGSLTGGYSENQLKAY-v...................
A0A3E2XKM3_9FIRM/726-883             ...................n-TQYKYVYAGLTWSEYWANEAVYA...AGDS...--STSEAVDKRGESDKGAFDTVTRATANHGLHRGSFQCIATIYDADG....NSYKVAGWKSAS.............................-ELLLTDGS..TVA..FN...SKA.....KT..VNG-...--KTFDHYEVTGLKYVPVKVAAADYEDFCNKYVVVENGGTLTGGYSEVNLSSYT....................
A0A416BIV9_9FIRM/78-239              ....................EESYKYVYAGLSWEQFWASEGVYN...ATNT...--DANAETDAKGELDKGGFDTVTRATANHGLHRGSFQCIATIYDENG....GTYQISHWTDGG.............................KTIVLTDGS..TVA..FE...RGT.....IT..KADG...TSVMMEHYEIYGMKYIPVAVKAEDYDAFKQQYSVVETGGTVVGGYGEQRLVEY-s...................
R7ISI0_9FIRM/153-312                 ....................EDEYTYVYAELTYDEYYAAEPVQN...GDSA...--ESSDETDTRGEYDKGAFDAVTRATTNHGLHRGSFQSAVVIYDTEG....NVYEAAGWDGKN.............................-TIILTDGT..TVG..FD...RGT.....IT..IGE-...ETKTMAGYEVTGFKYIPVAVKTSDYEEFKNQYKVVENGETLFGGFSEVNLSAYS....................
R6AYB7_9FIRM/142-277                 atyssrgiinavnagvsvcl------------------------...----...---------CSAELDMGAFDTVSRATTNHGLHRGSYQCTSEITKKDG....TKLKVTYYTGAA.............................-TGVLTNGE..AFS..YD...KNE.....--..----...----IESYVVTGLKYVPVKVKTEDYEAFKAAYTVVENGSTLSGGFSEENLKNYT....................
R5UYY2_9FIRM/33-194                  ....................DEDYVYCAAALSWAEYWEQEGVFL...SDDAngdWTAESADSDTRGESDLGAYDTVTRATSNHGLHRGSYQCTVKVYDTDG....NAYDYTGKGNGE.............................SVDVVK-GD..---..-N...GTM.....IT..VDGK...EVGTYDHSMILGPKYVPVAVPASLYDDFKQKYSVLENGDSMVGGYTEKNLVA--in..................
A0A174A0X0_CLOVE/47-240              ..................nv--TYVYGYAPLSYAQYWAGELD-K...SVEE...LSKSSDKTDSEGVNDAGMFDAVTRATAKHGIYRQQFQYIVEVTGEKV....ISSEVVEENGKEttkyttdsndtqtvtvqasfdgvdsegtiTTAPVDD--..NVV..FE...DASs...iFT..IGEGdsaTQYKVAEYKVLGFNNIPVAIPSDMVDSAKEN-GFVEDSN---------------vssdtyglktmnsdg.....
R6BNT1_9FIRM/35-217                  ....................DSDYKYVYASLDWAEYWQNENVYL...ASGS..tLKSSSEEADARGEYDKGAFDVVTRATKNHGLHRGSFQCDAVIRDTDG....KAYEISYWTSEEvsakden..............gqdttkkvVYAVLTDGS..KIQ..FD...KGT.....IT..YTENgetKTATMEDYEVKGIKYVPVAVKTEDYADFCKKYSVTEDASAIEGGYTENALKAYT....................
R6GB89_9FIRM/1-50                    ....................------------------------...----...-----------------------------------------------....------------.............................---------..---..--...---.....--..----...----MKDYKVYGLKYVPVAVKSSDFEAFKAKYSVVENNGTLIGGYGEKNLQAYN....................
R7I128_9CLOT/42-207                  ....................QEEYEYVYAGISWAQYWESEGIYL...SGTN...MVASSSAVDTRGESDKGAFDAVSRATTNHGIHRGSFQCNTTIYGEDG....KTFDVSTWKSAS.............................-ELVLTDGS..TVG..FN...KGT.....IT..YTENgqeKTTTMKNYNVTGIKYVPVAVKKSDYEAFAAQYPVVSNAGILVGGYSETNLASYQ....................
R5U519_9FIRM/578-743                 ..................ap--EYTYVYASVPYAEYYANEDVQN...AGSA...--ASSDVMDTNGEYDKGAFDTVTRATANHGLHRGSFQQDVVIYDTDG....NTYEPISWTDGN.............................-TAILSNGK..TLVkaSD...RAT....gITtlTVDG...KTSTYDHYVIKGIKYVPVKVKSKNLEAFKAAYSVTENGETLSGGYSENNLKSYT....................
U2KAE3_9FIRM/47-210                  ...................t-TDYVYCAASLTWAEYWENEGVYLdsaADGN...WEASSADADSHGETDLGAYDAVTRATSNHGLHRGSYQCTVKVFDTEG....NSYDYTGRGQNE.............................SVDVVSNRD..A--..-G...TTT.....VM..VDGK...AAGAYDHSVIVGPKYVPVAVPAADYEDFKKAYTVYENGTEVKGGYTEKNLV---nid.................
TA47_TREPA/24-220                    ..................hh--ETHYGYATLSYADYWAGELGQS...-RDV...LLAGNAEADRAGDLDAGMFDAVSRATHGHGAFRQQFQYAVEVLGEKV....LSKQETEDSRGRkkweyetdpsvtkmvrasasfqdlgedgeIKFEAVEGA..VAL..AD...RAS.....SF..MVDS...EEYKITNVKVHGMKFVPVAVPHELKGIAKEKFHFVEDSR---------------vtentnglktmltedsfsar
#=GR TA47_TREPA/24-220         SS    ..................XX---EEEEEEEEEHHHHHHHHHT--...-TGG...G---------TT----SSSS-EEEE--SHHHHHHTTTEEEEEEEEEE....EEEEEEE-TTS-EEEEEEEEEEEEEEEEE-EEEEEE-TTS-EEEEE-TTS..B--..-T...T-S.....EE..EETT...EEEEEEEEEEEEEEEEEEEEEGGGHHHHHHHC--EE-TT-----------------TT-TTBEEEEETTEE---
A0A373LFV6_9FIRM/1-41                ....................------MYAGLTWQECWASEGVYE...AGNV...--QSSEAEDSRGCNN--------------------------------....------------.............................---------..---..--...---.....--..----...------------------------------------------------------khlntm..............
A0A1G5CWJ6_9FIRM/125-286             ..................tg--EYQYVYAGLTWGEYWAAEGVYA...AGDT...--SSSEEKDSHSEFDTGAFDTVTRATANHGLHRGSYQTEATIIAEDG....TRFDVSYWEDKG.............................STLYLTDGS..KVK..WN...RGS.....IT..TEDG...KTYTMDHYEIYGLKYVPVAVKTADFADFCKKYNVVQDGAVLSGGYSENNLQYYK....................
D4M2N0_9FIRM/649-809                 ....................ESEYTYAYVGLSWAEYWAAENVQA...AGDT...--SSSDAKDSKGESDKGAFDTVTRATVNHGLHRGSFQCNAVIKAENG....KEYAVEYWTDGT.............................-TAVLTDGS..KIT..FN...RGE.....IT..EESG...ATTKMTEYDVLGLKYVPVKVKTSDLDALKASYRVIENGSELAGGYSEKNLVSYT....................
C4Z2X1_EUBE2/34-195                  ....................DDEYSYVYAGLTWQEYWANEGVYN...AGDV...--TSSNEKDTHGEYDKGAFDTVTRATTNHGLHRGSYQCMATIDTEDG....NKYELAGWSSDG.............................KQMILTDGT..QLS..YN...RGT.....IT..NADG...STSKVSSYEVTGIKYVPVKVKTSDLADFEQHYRVVKNGEKLYGGFGENKLSSYE....................
A0A2U1B742_9FIRM/817-969             ..................tp--TYTYAYAAVPYDEYWQSEGVYL...NKGS..eWDAGFDARDGHNEYDKGAFDAVSRATTNHGLHRGSFQQSVVIHTADK....DYYPV-AWTDGD.............................-NFVDADGK..--T..YN...KKE.....IG..IT--...------SYNITGIKYVPVKVSSSDFADFCKQYTVTKNGETLQGGYSEFNLNAYT....................
R5S9W5_9CLOT/32-196                  ...................a-DDYTYLYAGLTWDQYWDAEDIYL...QSTK..sMTDANTEADARGELDKGAFDAVSRATTNHGLHRGSYQCDTVIYGEDG....SEFNVSHWSADG.............................KTLYLTDGT..SVS..YS...KGT.....IT..KADG...SQTKLKEYKVTGLKYVPVAVKTSELSDFKKIYKVVENDGELAGGYSEMNLSAY-d...................
R6V2K1_9FIRM/654-820                 ....................EEKYKYVYAGLSWAEYWASEGVYL...AEGS..nLASSSDVADKKGELDKGAFDTVSRATTNHGLHRGSYQCTAVIYDTDG....KEYPVSYWNSSS.............................-EAVLTDGS..VIT..FN...KGT.....IT..YNENgteKTATMKDYEVKGIKYVPVKVKTADYDEFCKKYQVVENAGTLAGGFTEKNLQAYT....................
A0A174ANB4_9FIRM/534-702             .................ysl---YSYVYAGLTWGEYWSQENVTA...AGNV...--SGSDEKDSHNESDTGAFDAVTRATTNHGLHRGSYQCMATIYTTEG....NTYQLSYWKSST.............................-EPVLADGT..VAN..WTpadRKTgtpasIQ..VNGG...AKESLDHYAVTGIKYVPVQVKAEDYADFAAKYPVVKNGETFVGGFSENNLKAY-r...................
D4MVX7_ANAHA/43-213                  ...................s-DEYVYCYAGLTWNEYWASEGVYA...AGND...--SSSDTLDSHNELDNGGYDAVTRATTNHGLHRGSFQCITTIYTTDG....IAYQISNWEQVKgsdg.....................kvtaTYLHLKDVE.gRVT..FN...KGT.....LT..FADN...STKKMDHYSVSGIKYVPVKVKASDYNDFKAKYSVVENNGTLIGGYTEGVLSSYK....................
R7JW13_9FIRM/675-825                 ...................e-TTYKYVYAGLTWAEYWAAEGVQA...AGSD...--AGSDETDSREESDKGAFDVVTRATTNHGLHRGSFQCAATIYMKDG....TTYDVAYYTAAT.............................-TAVLTNGE..TVT..YD...KSQ.....--..----...----IDHYEVKGLKYVPVKVSEDDYEDFCKKYVVVENGGTLSGGFSENKLQSYT....................
R7NKY5_9FIRM/39-208                  ...................a-KDYTYVFAGLTWDEYWKSEGVYV...ADNN...WTASSDVLDSHNEYDKGAFDVVSRATTNHGLHRGSFQCSTDIVATDAdgneKIFTISYWTKEDn...........................kTVLVLKDGS..KIT.dYA...KGK.....FT..YNN-...VAYTMAHYYVKGMKYIPVAVKNDDLADFESKYTVVKSGEAVEGGYSEGVLSSYS....................
R7FCJ1_9FIRM/35-197                  ...................t-ADYVYCYAALTWAEYWQNEGVYLddaADGD...LGASSTEKDTHGEYDLGAYDAVTRATSNHGLHRGSYQCTVKVYDTEG....NAYDYTGKGQDE.............................SVDVVKNGN..---..-G...GAD.....IT..VNGE...VAGTYDHSVNVGPKYVPVAVPADEYEAFKEAYTVYENGDTITGGYTEKNLV---nin.................
R6LRK9_9FIRM/665-830                 ...................k-SEYSYVYVGMSWSEYWAKEGVYA...AGDT...--GSSSDVDSRNEYDKGAFDAVTRATANHGLHRGSFQCSAVIEDTNG....NKYELAYWNADG.............................-KAVMSDGSvyTRS..TNedkKAV.....FT..AEDG...SSFIQADYKVTGIKYVPVKVKTADLNALQEEYAVVENGGTLSGGFSENQLQSYT....................
R7C694_9CLOT/40-207                  ....................DESYTYLYADLNWAEYWAAEDVYL...KDGK..nMTDSNETEDARGELDKGAFDAVSRATTNHGLHRGSFQCDAVITADNG....QNYPVSYWEQDKd..........................knQSFYTTDGQ..KIG..YA...KGV.....MT..LPDA...STTKVVNYTVTGIKYVPVAVKTADLQDFKSKYKVVENGEKLVGGYSENALSSYE....................
#=GC SS_cons                         ..................XX---EEEEEEEEEHHHHHHHHHT--...-TGG...G---------TT----SSSS-EEEE--SHHHHHHTTTEEEEEEEEEE....EEEEEEE-TTS-EEEEEEEEEEEEEEEEE-EEEEEE-TTS-EEEEE-TTS..B--..-T...T-S.....EE..EETT...EEEEEEEEEEEEEEEEEEEEEGGGHHHHHHHC--EE-TT-----------------TT-TTBEEEEETTEE---
#=GC seq_cons                        .....................tpYpYsYAuLoWsEYWssEsVYh...Asss.....uSSsptDo+GEhDpGAFDsVTRATsNHGLHRGSaQCsssIhsp-G....ppYplshWssss..............................phlLsDGs..pls..as...+us.....lT..hsst...tshphccYpVpGlKYVPVtVKssDapsFpppYsVVENGssL.GGYoEpsLpuYp....................
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