#=GF ID   HTH_SpdB_C
#=GF AC   PF27079.2
#=GF DE   SpdB plasmid transfer protein, C-terminal HTH domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   TED:P22408_TED03
#=GF GA   58.00 58.00;
#=GF TC   59.90 59.40;
#=GF NC   56.70 57.50;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -E 1000 -Z 90746521 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0123
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents the C-terminal helix-turn-helix (HTH)
#=GF CC   domain (residues 242-287) of SpdB, a plasmid transfer protein
#=GF CC   from Streptomyces species. SpdB is encoded on conjugative
#=GF CC   plasmids such as pIJ101 from Streptomyces lividans and functions
#=GF CC   in bacterial conjugation. The full-length protein is a 291 amino
#=GF CC   acid multi-pass membrane protein with three transmembrane
#=GF CC   helices in the N-terminal region. This C-terminal HTH domain
#=GF CC   likely functions in DNA binding or protein-protein interactions
#=GF CC   required for plasmid transfer. The domain is located in the
#=GF CC   cytoplasmic region following the membrane- spanning segments,
#=GF CC   where it may regulate conjugative transfer or interact with
#=GF CC   other components of the conjugation machinery.
#=GF SQ   132
#=GS A0A2N8PQA4_STRNR/314-367  AC A0A2N8PQA4.1
#=GS A0A7K2ZBH3_9ACTN/238-288  AC A0A7K2ZBH3.1
#=GS A0A2T7T6G2_9ACTN/244-294  AC A0A2T7T6G2.1
#=GS A0A4S5B1M2_9ACTN/220-267  AC A0A4S5B1M2.1
#=GS A0A081XRI2_STRTO/237-286  AC A0A081XRI2.1
#=GS A0A1H9XET5_9ACTN/250-299  AC A0A1H9XET5.1
#=GS A0A089XB01_STRGA/235-284  AC A0A089XB01.1
#=GS A0A7W7LMN4_9ACTN/295-348  AC A0A7W7LMN4.1
#=GS A0A5N8XD73_9ACTN/298-351  AC A0A5N8XD73.1
#=GS A0A918BV23_9ACTN/235-285  AC A0A918BV23.1
#=GS A0A117RW14_9ACTN/237-286  AC A0A117RW14.1
#=GS A0A7H0I3T8_9ACTN/225-274  AC A0A7H0I3T8.1
#=GS A0A7L4Y407_9ACTN/236-286  AC A0A7L4Y407.1
#=GS A0A1Q4VB55_9ACTN/233-283  AC A0A1Q4VB55.1
#=GS A0A124HCB0_9ACTN/282-335  AC A0A124HCB0.1
#=GS A0AA38HHD2_9CUCU/311-364  AC A0AA38HHD2.1
#=GS A0A7H8IUG9_9ACTN/235-284  AC A0A7H8IUG9.1
#=GS A0A2M8M652_9ACTN/331-384  AC A0A2M8M652.1
#=GS A0A6G2RX13_9ACTN/237-287  AC A0A6G2RX13.1
#=GS A0A0L8KW25_9ACTN/237-286  AC A0A0L8KW25.1
#=GS A0A0U2WQ14_9ACTN/236-285  AC A0A0U2WQ14.1
#=GS A0A940YWA3_9ACTN/237-286  AC A0A940YWA3.1
#=GS A0A7K2TD05_9ACTN/315-368  AC A0A7K2TD05.1
#=GS A0A0J6XKF1_9ACTN/295-348  AC A0A0J6XKF1.1
#=GS A0A7H8IQY6_9ACTN/235-284  AC A0A7H8IQY6.1
#=GS A0A7W7M2I7_9ACTN/237-287  AC A0A7W7M2I7.1
#=GS A0A6J8BLC6_MYTCO/126-178  AC A0A6J8BLC6.1
#=GS A0A0M9ZZT2_9ACTN/226-275  AC A0A0M9ZZT2.1
#=GS A0A7H8NKE8_9ACTN/305-358  AC A0A7H8NKE8.1
#=GS A0A2M9MBD3_9ACTN/318-371  AC A0A2M9MBD3.1
#=GS A0A1D2IFV2_9ACTN/237-287  AC A0A1D2IFV2.1
#=GS A0A7H0I5A1_9ACTN/299-352  AC A0A7H0I5A1.1
#=GS A0A177HLL7_9ACTN/314-367  AC A0A177HLL7.1
#=GS A0A171BE16_9ACTN/316-369  AC A0A171BE16.1
#=GS A0A6B2VC84_9ACTN/237-287  AC A0A6B2VC84.1
#=GS A0A5P2BDC6_STRVZ/236-285  AC A0A5P2BDC6.1
#=GS A0A4U0N8W6_9ACTN/236-286  AC A0A4U0N8W6.1
#=GS A0A150VZD6_9ACTN/236-289  AC A0A150VZD6.1
#=GS A0A2U2Z088_9ACTN/313-366  AC A0A2U2Z088.1
#=GS A0A1C4MW48_9ACTN/235-284  AC A0A1C4MW48.1
#=GS A0A918UHP0_9ACTN/239-288  AC A0A918UHP0.1
#=GS F3NJ30_9ACTN/236-285      AC F3NJ30.1
#=GS A0A1C4MWR3_9ACTN/219-268  AC A0A1C4MWR3.1
#=GS A0A365Z931_9ACTN/235-285  AC A0A365Z931.1
#=GS A0A3N6GM58_9ACTN/239-290  AC A0A3N6GM58.1
#=GS A0A494UTP1_9ACTN/237-286  AC A0A494UTP1.1
#=GS A0A926PZB3_9ACTN/298-351  AC A0A926PZB3.1
#=GS A0A926GPL3_9ACTN/331-384  AC A0A926GPL3.1
#=GS A0A918HCY8_9ACTN/295-348  AC A0A918HCY8.1
#=GS A0A940XFT4_9ACTN/310-363  AC A0A940XFT4.1
#=GS A0A5N8XWF5_9ACTN/298-343  AC A0A5N8XWF5.1
#=GS A0A918ZKN4_9ACTN/237-286  AC A0A918ZKN4.1
#=GS A0A0Q9AKJ1_9ACTN/241-290  AC A0A0Q9AKJ1.1
#=GS A0A1S6JGH5_9ACTN/315-368  AC A0A1S6JGH5.1
#=GS A0A1H4Y091_9ACTN/282-335  AC A0A1H4Y091.1
#=GS A0A4Z0GGZ7_9ACTN/333-386  AC A0A4Z0GGZ7.1
#=GS A0A510TQ94_9ACTN/312-365  AC A0A510TQ94.1
#=GS A0A124I5V7_9ACTN/295-348  AC A0A124I5V7.1
#=GS A0A3N4S910_9ACTN/285-338  AC A0A3N4S910.1
#=GS A0A2U2Z7U3_9ACTN/237-286  AC A0A2U2Z7U3.1
#=GS A0A918IC18_9ACTN/298-351  AC A0A918IC18.1
#=GS E2Q6K6_STRCL/295-348      AC E2Q6K6.1
#=GS C9YWM5_STRSW/237-290      AC C9YWM5.1
#=GS A0A250VE02_STROL/240-290  AC A0A250VE02.1
#=GS A0A7X0HP97_9ACTN/308-361  AC A0A7X0HP97.1
#=GS A0A494V3F7_9ACTN/237-286  AC A0A494V3F7.1
#=GS A0A124HWU8_9ACTN/237-286  AC A0A124HWU8.1
#=GS A0A1I2G5E3_9ACTN/295-348  AC A0A1I2G5E3.1
#=GS A0A0C2AUZ8_9ACTN/313-366  AC A0A0C2AUZ8.1
#=GS D5SIJ3_STRCL/412-465      AC D5SIJ3.1
#=GS A0A0M8VJ81_9ACTN/225-274  AC A0A0M8VJ81.1
#=GS A0A7K2TKT6_9ACTN/236-289  AC A0A7K2TKT6.1
#=GS A0A4Z0FR61_9ACTN/361-414  AC A0A4Z0FR61.1
#=GS A0A5J5C804_9PERO/70-122   AC A0A5J5C804.1
#=GS A0A7W7PNN7_9ACTN/237-286  AC A0A7W7PNN7.1
#=GS A0A1E5PPW7_9ACTN/298-351  AC A0A1E5PPW7.1
#=GS A0A4S5D9N5_9ACTN/250-297  AC A0A4S5D9N5.1
#=GS A0A117PHK1_9ACTN/235-285  AC A0A117PHK1.1
#=GS A0A250VG00_STROL/237-287  AC A0A250VG00.1
#=GS A0A918EMP1_9ACTN/235-285  AC A0A918EMP1.1
#=GS A0A919A445_9ACTN/236-286  AC A0A919A445.1
#=GS A0A919B920_9ACTN/290-343  AC A0A919B920.1
#=GS A0A918B0V3_9ACTN/236-286  AC A0A918B0V3.1
#=GS G2GLX0_9ACTN/241-291      AC G2GLX0.1
#=GS A0A1H5BQL0_9ACTN/239-288  AC A0A1H5BQL0.1
#=GS A0A1R1SI05_9ACTN/279-332  AC A0A1R1SI05.1
#=GS A0A1A5P0W5_9ACTN/237-286  AC A0A1A5P0W5.1
#=GS A0A5J5C8I3_9PERO/102-154  AC A0A5J5C8I3.1
#=GS A0A0Q9ASF8_9ACTN/241-290  AC A0A0Q9ASF8.1
#=GS A0A4S5CGV6_9ACTN/118-171  AC A0A4S5CGV6.1
#=GS A0A4Q9HY72_STRKA/346-399  AC A0A4Q9HY72.1
#=GS A0A6B3AT68_9ACTN/237-287  AC A0A6B3AT68.1
#=GS A0A2N8P5P4_STRNR/237-286  AC A0A2N8P5P4.1
#=GS A0A1S2JZN7_9ACTN/311-364  AC A0A1S2JZN7.1
#=GS A0A944INQ9_9ACTN/225-275  AC A0A944INQ9.1
#=GS A0A5N8XQ19_9ACTN/298-351  AC A0A5N8XQ19.1
#=GS A0A1H5LD35_9ACTN/280-333  AC A0A1H5LD35.1
#=GS A0A0U3QDP6_9ACTN/368-421  AC A0A0U3QDP6.1
#=GS A0A944E2J3_9ACTN/237-288  AC A0A944E2J3.1
#=GS A0A2U2ZTH2_9ACTN/284-337  AC A0A2U2ZTH2.1
#=GS A0A0J6XP44_9ACTN/299-352  AC A0A0J6XP44.1
#=GS A0A3N4ZJB0_9ACTN/238-289  AC A0A3N4ZJB0.1
#=GS A0A2Z5K2Z7_9ACTN/236-285  AC A0A2Z5K2Z7.1
#=GS A0A089XEQ2_STRGA/295-348  AC A0A089XEQ2.1
#=GS A0A0F5VQ72_9ACTN/239-291  AC A0A0F5VQ72.1
#=GS A0A1M5Z6T1_9ACTN/233-284  AC A0A1M5Z6T1.1
#=GS A0A8S3SR08_MYTED/155-207  AC A0A8S3SR08.1
#=GS A0A2W2MIV6_9ACTN/235-284  AC A0A2W2MIV6.1
#=GS G2GJU0_9ACTN/241-291      AC G2GJU0.1
#=GS A0A917XHZ3_9ACTN/280-333  AC A0A917XHZ3.1
#=GS A0A3N4SG66_9ACTN/240-289  AC A0A3N4SG66.1
#=GS A0A6G2S3G1_9ACTN/240-290  AC A0A6G2S3G1.1
#=GS A0A1Q5KZH5_9ACTN/235-286  AC A0A1Q5KZH5.1
#=GS A0A3N6IDL9_9ACTN/237-288  AC A0A3N6IDL9.1
#=GS A0A1C4ID11_9ACTN/234-287  AC A0A1C4ID11.1
#=GS A0A941BUK0_9ACTN/237-287  AC A0A941BUK0.1
#=GS A0A6B3FH91_9ACTN/401-454  AC A0A6B3FH91.1
#=GS A0A9W7WRD2_TRIRA/163-215  AC A0A9W7WRD2.1
#=GS A0A291QB90_9ACTN/236-290  AC A0A291QB90.1
#=GS L7FID8_9ACTN/237-287      AC L7FID8.1
#=GS A0A171BGV5_9ACTN/235-291  AC A0A171BGV5.1
#=GS A0A9W7X2S8_TRIRA/149-201  AC A0A9W7X2S8.1
#=GS A0A6I6N7U3_9ACTN/295-348  AC A0A6I6N7U3.1
#=GS C9Z133_STRSW/237-287      AC C9Z133.1
#=GS A0A919H3W2_9ACTN/299-352  AC A0A919H3W2.1
#=GS A0A066YR77_9ACTN/364-417  AC A0A066YR77.1
#=GS A0A918FUW1_9ACTN/237-290  AC A0A918FUW1.1
#=GS A0A8T4IY69_9ACTN/234-287  AC A0A8T4IY69.1
#=GS A0A918HI21_9ACTN/237-290  AC A0A918HI21.1
#=GS A0A8S3R8N7_MYTED/104-156  AC A0A8S3R8N7.1
#=GS A0A918RVT2_9ACTN/236-289  AC A0A918RVT2.1
#=GS A0A3N6GV22_9ACTN/236-287  AC A0A3N6GV22.1
A0A2N8PQA4_STRNR/314-367             LTDEQLVVVL.RHLRYRDDP...PLSYRQAGTDFRDAGFVGSEQRVRRAWGALLSHEE...
A0A7K2ZBH3_9ACTN/238-288             LSDAELDRLV.DEIRHSETP...ALSYREMSTRFRAAGHAASEFRLRAAWKRVA----a..
A0A2T7T6G2_9ACTN/244-294             LTDAALDVLV.DQIRHSESP...ALSYREMAARFRTAGHSASEVRLRAAWKRVA----a..
A0A4S5B1M2_9ACTN/220-267             FSDAELDAVV.DEIRCSQAP...PLSYREMALRFRAAGRSAAEMRLRAAWRR------...
A0A081XRI2_STRTO/237-286             LTDEALDVLV.DEIRHSETP...ALSYREMAARFRAAGHSASEVRLRAAWKRV-----a..
A0A1H9XET5_9ACTN/250-299             LTDDELDALV.DEIRHSETP...ALSYREMAARFRAAGHSASEGRLRDAWKRV-----a..
A0A089XB01_STRGA/235-284             LTDTALDDLV.REIRDSEVP...ALSYREMAARFRAAGHSASEVRLRAAWKRV-----a..
A0A7W7LMN4_9ACTN/295-348             LTDAQLVVVL.RNLRYTDDP...PLSYRQAVTAFREGGFVGGEQRVRKAWGSLMSHEE...
A0A5N8XD73_9ACTN/298-351             LTDAQLVVVL.RHLRYSDDP...PLSYRQAVAAFREGGFVGGEQRVRKAWGSLMSHEE...
A0A918BV23_9ACTN/235-285             LTDEALDALV.DEIRHSEVP...ALSYREMATRFRGAGHSASEVRLRAAWKRVV----a..
A0A117RW14_9ACTN/237-286             LTDAALDVLV.DEIRHSETP...TLSYREMAIRFRTAGHSASEMRLRAAWKRV-----v..
A0A7H0I3T8_9ACTN/225-274             LTDAELDRLV.DDIRHSETP...SLSYREMAVRFRAAGHSASEVRLRAAWKRV-----a..
A0A7L4Y407_9ACTN/236-286             LTDDALDALV.DQIRHSQTP...ALSYREMATRFRAAGHSASEVRLRAAWKRVA----a..
A0A1Q4VB55_9ACTN/233-283             LTNDQLDQVV.DQIRHSETP...ALSYREMAVRFRAAGHSASEVRLRAAWKRVA----a..
A0A124HCB0_9ACTN/282-335             LTEEQLMVVL.RWLRHSENP...PLSYRKALAAYRAAGFSAKEERVRKAYAALIDAE-d..
A0AA38HHD2_9CUCU/311-364             LTDAQLDVVL.RHLRYTDDP...PRSYRQARDDFRAAGFVGSEERVRRVWAALMENEE...
A0A7H8IUG9_9ACTN/235-284             LTDEALDALV.DEIRHSETP...ALSYREMSARFRAAGHSASEVRLRAAWKRV-----a..
A0A2M8M652_9ACTN/331-384             LSDEQLIVVL.RHLRYSVDP...PLSYRQAVAAFREAGYVGGEQRVRTAWGAVMSQEE...
A0A6G2RX13_9ACTN/237-287             LTDDALDEVV.EEIRTSRTP...PLSYREMSARFRAAGHSASEVRLRAAWKRVA----a..
A0A0L8KW25_9ACTN/237-286             LTDDALDALV.DEIRHSETP...ALSYREMAIRFRAAGHSASEVRLRAAWKRV-----a..
A0A0U2WQ14_9ACTN/236-285             LTDAELDALV.DSIRNSQTP...ALSYREMAVRFRAAGHSASEVRLRAAWKRV-----a..
A0A940YWA3_9ACTN/237-286             LTDDALDVVV.DEIRRSEDP...ALSYREMAARFRAAGHSASEVRLRAAWKRV-----v..
A0A7K2TD05_9ACTN/315-368             LTDTQLGVVL.RHLRYSDDP...PLSYRQARDDFRAAGFVGSEERVRRVWGALLTHEE...
A0A0J6XKF1_9ACTN/295-348             LTDVQLVVVL.RHLRYSDDP...PLSYRQAVTAFRDAGFVGGEQRIRTAWGALMSQEE...
A0A7H8IQY6_9ACTN/235-284             LTDEALDALV.DEIRNSETP...ALSYREMATRFRAAGYSASEVRLRAAWKRV-----a..
A0A7W7M2I7_9ACTN/237-287             LTDDALDVIV.DEIRTSETP...ALSYREMATRFRAAGHSASEVRLRAAWKRVA----a..
A0A6J8BLC6_MYTCO/126-178             ICDDDLDQLL.QPI-IEENP...HLGYRSIQARLKVCGHFCPETRVRAALVRLDPAA-v..
A0A0M9ZZT2_9ACTN/226-275             LTDDELDALV.DEIRHSQTP...ALSYREMAIRFRAAGHSASEVRLRAAWKRV-----a..
A0A7H8NKE8_9ACTN/305-358             LTDPQLAVVL.RYLRYDDDP...PLSYRQAVAAFREAGFVGGEARIRRTWGHLMSQEE...
A0A2M9MBD3_9ACTN/318-371             LSDEQLVVVL.RHLRYSVDP...PMSYRQAAAAFREAGYVGAESRVRAAWGVLMEQE-a..
A0A1D2IFV2_9ACTN/237-287             LTDEALDVVV.DEIRHSEAP...ALSYREMSARFRASGHSASEVRLRAAWKRVV----a..
A0A7H0I5A1_9ACTN/299-352             LTGPQLGVVL.RHLRYAEDP...PASYRQAVKAFRQAGYVGSEERVRHEWGALMSREE...
A0A177HLL7_9ACTN/314-367             LTDAQLLVVL.RFLRHSQNP...PLSYRQAAAEFRRRGFKGAEDRVREAWTALMARES...
A0A171BE16_9ACTN/316-369             LSDAQLLVVL.RHLRYAEDP...PLSYRQAVAAFREAGFVGGEQRVRRAWGALMSHEE...
A0A6B2VC84_9ACTN/237-287             LTDDALDVLV.DQIRHSESP...ALSYREMATRFRAAGHSASEVRLRAAWKRVV----a..
A0A5P2BDC6_STRVZ/236-285             LTDAALDQLV.DAIRTSEDP...ALSYRDMATRFRASGHSASEVRLRAAWKRV-----a..
A0A4U0N8W6_9ACTN/236-286             LTDDALDALV.DEIRHSEVP...ALSYNKMSTRFRAAGHSASEVRLRAAWKRVA----a..
A0A150VZD6_9ACTN/236-289             LSDAELDRIV.TELHTSEIP...PLSYRELSLRFRAAGHSASETRLRAAWRRVTTTA-s..
A0A2U2Z088_9ACTN/313-366             LTDGQLDVVL.RHLRYHDDP...PLSYRQAVTTFRDHGFVGSEKRVRRAWGALLSNEE...
A0A1C4MW48_9ACTN/235-284             LTDDALDVVV.DQIRLSQDP...PLSYREMSARFRAAGHSASEVRLRASWKRV-----a..
A0A918UHP0_9ACTN/239-288             LTDAELDALV.DRIRHSQTP...ALSYREMAARFRAAGHSASEVRLRAAWKRV-----a..
F3NJ30_9ACTN/236-285                 LSDDELDTLV.HDIRHSQTP...PLSYREMAARFRAAGHSASEVRLRAAWKRV-----a..
A0A1C4MWR3_9ACTN/219-268             LSDDALDAVV.DQIRHSQDP...ALSYREMAARFRATGHAASEVRLRAAWKRV-----v..
A0A365Z931_9ACTN/235-285             LTDEALDAVV.DQIRTSEDP...ALSYREMAARFRAAGHSASEVRLRAAWKRVA----a..
A0A3N6GM58_9ACTN/239-290             LSDEALEALV.DQIRHSETP...ALSYREMATRFRTAGHSASEVRLRAAWKRVEA---a..
A0A494UTP1_9ACTN/237-286             LTDDALDVIV.DDIRTSETP...ALSYREMAARFRAAGHSASEVRLRAAWKRV-----a..
A0A926PZB3_9ACTN/298-351             LTNEQITVVL.RALRYSEDP...PMSYRQAAAEFRRAGYLGGEDRVRPLWRELKKQES...
A0A926GPL3_9ACTN/331-384             LTDEQITVVL.RWLRYDMEP...PRSFNQAREAYRKAGFKGAENRIRPLWALIEAAE-a..
A0A918HCY8_9ACTN/295-348             LSDAQLVVVL.RHLRYSDDP...PLSYRQAVAAFREGGFVGGEQRVRKAWGSLMSHEE...
A0A940XFT4_9ACTN/310-363             LTDAQLDVAL.RHLRYTDDP...PRSYRKARDDFRDAGFVGSEARVRRVWGALLTHEE...
A0A5N8XWF5_9ACTN/298-343             LTDAQLVVVL.RHLRYSDDP...PLSYRQAVAAFREGGFVGGEQRVRKAW--------...
A0A918ZKN4_9ACTN/237-286             LTDEALDALV.NEIRHSEDP...ALSYREMAARFRAAGHSASEVRLRAAWKRV-----a..
A0A0Q9AKJ1_9ACTN/241-290             LTDAQLDALV.DTIRHSQTP...ALSYREMAVRFRAAGHSASEVRLRAAWKRV-----a..
A0A1S6JGH5_9ACTN/315-368             LSDAQLCVVL.RHLRYTDDP...PRSYRHAQKEFRDRGFVGSDERLRRAWGALLTHEE...
A0A1H4Y091_9ACTN/282-335             LTEEQLTVVL.RWLRHSENP...PLSYRKALIAYRAAGFSAKEERVRKAYAALIDAE-d..
A0A4Z0GGZ7_9ACTN/333-386             LTDDQLDVVL.RHLRYSEDP...PLSYRQAVTAFRDGGYVGGEQRVRKAWGQLMSHEE...
A0A510TQ94_9ACTN/312-365             LTDAQIGVVL.RHLRYCDDP...PLSFRQARASYRGAGYQGSEERIRHAWAALRANE-g..
A0A124I5V7_9ACTN/295-348             LTDVQLVVVL.RHLRYSDDP...PLSYRQAVAAFRESGFVGGEQRVRRAWGSLMSHEE...
A0A3N4S910_9ACTN/285-338             LTEEQLTVVL.RWLRHSENP...PLSYRKALAAYRAAGFSAKEERVRKAYAALIDAE-d..
A0A2U2Z7U3_9ACTN/237-286             LSDDALAALV.DDIRHSESP...ALSYREMATRFRAAGHAASEVRLRAAWKRV-----a..
A0A918IC18_9ACTN/298-351             LTDEQLIVVL.RHLRYSDDP...PLSYRQAVTAFREGGFVGGEQRVRKAWGSLMSHEE...
E2Q6K6_STRCL/295-348                 LTEDQLMVVL.RYLRHSEDP...PLSYRQALAAYRAAGYVGGDARIRLVWTALLARE-g..
C9YWM5_STRSW/237-290                 LSDTALDALV.DEIRHSETP...ALSYREMAIRFRATGHSASEMRLRAAWKRVVAH--ps.
A0A250VE02_STROL/240-290             LTDEALDTLV.DEIRHSETP...ALSYREMATRFRAAGHSASEVRLRAAWKRVV----a..
A0A7X0HP97_9ACTN/308-361             LSDEQIEVVL.RWLRYDMDP...PRSYRQAVEDYRKHGFVGGESRIRPIWALIEARE-k..
A0A494V3F7_9ACTN/237-286             LTDEALDVIV.DEIRTSETP...ALSYREMAARFRAAGHSASEMRLRAAWKRV-----a..
A0A124HWU8_9ACTN/237-286             LTDAALDALV.DEITHSETP...ALSYREMAARFRQAGHSASEVRLRAAWKRV-----a..
A0A1I2G5E3_9ACTN/295-348             LSDAHLDVVL.RWLRYQTDP...PLSYRQAVSAFRVAGFVGAEDRVRRAYAALVARD-g..
A0A0C2AUZ8_9ACTN/313-366             LTDGQMEVVL.RQFRYSDDP...PLSYRQAMSAFRAAGFVGSEERVRRVWAGLMSKEE...
D5SIJ3_STRCL/412-465                 LTGTQLVVVL.RHLRYREDP...PLSYRQAVAAFREAGFVGGEERIRRTWAELTAQE-g..
A0A0M8VJ81_9ACTN/225-274             LTDDALDSLV.DDIRHSEDP...ALSYREMSSRFRAAGHSASEVRLRAAWKRV-----v..
A0A7K2TKT6_9ACTN/236-289             LTDDALDTLV.DQIRHSRTP...PLSYREMATRFRTAGHSASEVRLRAAWKRVAER--pa.
A0A4Z0FR61_9ACTN/361-414             LTDEQLRVVL.RHFRHRDDP...PRSYRKAVAAFRDEKFQGGEERVRPIWNELMKSE-g..
A0A5J5C804_9PERO/70-122              LTDDELDILV.SAI-HSSSP...NAGYRMMMGLLRAQGHRVQWQRIRASMHRVDTV--gi.
A0A7W7PNN7_9ACTN/237-286             LTDEALDVLV.DEIRTSETP...ALSYREMATRFRAAGHSASEVRLRAAWKRV-----a..
A0A1E5PPW7_9ACTN/298-351             LTDEQIVVVL.RFLRYSADP...PLSYRQTVTAFRESGFTGGEARIRGAWATLMAQEE...
A0A4S5D9N5_9ACTN/250-297             FSDAELDAVV.DEIRCSQTP...PLSYREMALRFRTAGRSAAEMRLRAAWRR------...
A0A117PHK1_9ACTN/235-285             LTDAALDALV.DEIRHSETP...ALSYREMATRFRAAGHSASEVRLRAAWKRVA----a..
A0A250VG00_STROL/237-287             LTDEALDALV.DEIRHSETP...ALSYREMATRFRASGHSASEVRLRAAWKRVV----a..
A0A918EMP1_9ACTN/235-285             LTDGELDRLV.DEIRRSQTP...ALSYREMSIRFRAAGHSASETRLRAAWKRVA----a..
A0A919A445_9ACTN/236-286             LSDDALDTLV.HDIRHSQTP...PLSYREMAARFRAAGHSASEVRLRAAWKRVA----a..
A0A919B920_9ACTN/290-343             LTARQLDVVL.RHLRYSTDP...PTSYRQARDHFRDAGFVGSEERIRLAWAVLMANE-k..
A0A918B0V3_9ACTN/236-286             LTDGELDRLV.DEIRRSQTP...ALSYREMSIRFRAAGHSASETRLRAAWKRVV----a..
G2GLX0_9ACTN/241-291                 LTDAQLDELV.EEIRDSRTP...PLSYREMATRFRTAGHAASEVRLRAAWKRVV----a..
A0A1H5BQL0_9ACTN/239-288             LTDAELDSLV.DEIRHSEIP...ALSYREMAIRFRAAGHSASEVRLRAAWKRV-----a..
A0A1R1SI05_9ACTN/279-332             LSDVQLVVVL.RHLRYSDDP...PLSYRQAVAAFREAGFVGGEQRVRRAWGSLMSHEE...
A0A1A5P0W5_9ACTN/237-286             LTDEALDVVV.DEIRHSETP...ALSYREMSARFRAAGHSASEVRLRAAWKRV-----a..
A0A5J5C8I3_9PERO/102-154             LTNDELDILV.SAI-HSSSP...NAGYRMMMGLLRAQGHRVQWQRIRASMHRVDTV--gi.
A0A0Q9ASF8_9ACTN/241-290             LTDAQLDAVV.DTIRHSQTP...ALSYREMAVRFRAAGHSASEVRLRAAWKRV-----a..
A0A4S5CGV6_9ACTN/118-171             FSDAELDAVV.DEIRCSQTT...PLSYREMALRFRAAGHSAAEMRLRAAWRRVTTQT-d..
A0A4Q9HY72_STRKA/346-399             LSDTQLVVVL.RHLRYREDP...PLSYRQAVTAFRDAGFVGGEERIRRTWGELMSSEE...
A0A6B3AT68_9ACTN/237-287             LTDEALDVIV.DEIRTSETP...ALSYREMAARFRAAGHAASEMRLRAAWKRVA----a..
A0A2N8P5P4_STRNR/237-286             -SDDALDVLV.EEIRTSRTP...PLSYREMSARFRAAGHSASEVRLRAAWKRVA----a..
A0A1S2JZN7_9ACTN/311-364             LTDGQLDVVL.RHLRYRDDP...PLSYRQARDHFRDSGYVGSEARVRRSWAALMSNEQ...
A0A944INQ9_9ACTN/225-275             LSDDALDTLV.HNIRHSQTP...PLSYRDMAARFRAAGHSASEVRLRAAWKRVA----a..
A0A5N8XQ19_9ACTN/298-351             LTDAQLVVVL.RHLRYSDDP...PLSYRQAVAAFREGGFVGGEERVRKAWGSLMSHEE...
A0A1H5LD35_9ACTN/280-333             LTEEQLTVVL.RWLRHSENP...PLSYRKALAAYRAAGFPAKEERVRKAYAALIDAE-d..
A0A0U3QDP6_9ACTN/368-421             LTEAQLEVVL.RHLRYSDDP...PLSYRQAVAAFRDAGFVGGEERVRRVWGHLMSHEE...
A0A944E2J3_9ACTN/237-288             LTDEALDRLV.DEIRHSETP...ALSYREMATRFRAAGHSASEVRLRAAWKRVV----gg.
A0A2U2ZTH2_9ACTN/284-337             LTEEQLTVVL.RWLRHSENP...PLSYRKALAAYRAAGFSAKEERVRKAYADLVEAE-d..
A0A0J6XP44_9ACTN/299-352             LSDEQLVVVL.RHLRYSADP...PLSYRQAVTAFRDAGFVGGEQRVRKAWGVLMSQEE...
A0A3N4ZJB0_9ACTN/238-289             LTDAALDALV.DEIRHSQTP...TLSYREMATRFRAAGHSASEVRLRAAWKRVVA---a..
A0A2Z5K2Z7_9ACTN/236-285             LSDEALDALV.DEIRTSEVP...ALSYREMAARFRAAGHSASEVRLRAAWKRV-----a..
A0A089XEQ2_STRGA/295-348             LSDEQMAVVL.RHLRYSDDP...PLSYRKARADYRGAGFVGSEERVRHVWGTVLMAE-g..
A0A0F5VQ72_9ACTN/239-291             LTDAALDALV.EEIRTSETP...ALSYREMAKRFRAAGHSASEVRLRAAWNRVTAV--a..
A0A1M5Z6T1_9ACTN/233-284             LTDEALDRVV.HEIRHSQTP...ALSYREMAARFRAAGHSASEVRLREAWKRVVA---a..
A0A8S3SR08_MYTED/155-207             ICDDDLDQLL.QPI-IEENP...HIGYRSIQARLKVCGHFCQETRVREALVRLDPAA-v..
A0A2W2MIV6_9ACTN/235-284             LTDAALDALV.EEIRNSETP...ALSYREMATRFRAAGHSASEVRLRAAWKRV-----a..
G2GJU0_9ACTN/241-291                 LTDAQLDVLV.EEIRDSRTP...PLSYREMATRFRTAGHAASEVRLRAAWKRVA----a..
A0A917XHZ3_9ACTN/280-333             LTEEQLTVVL.RWLRHSDNP...PLSYRKALAAYRAAGFSAKEERVRKAYAALIDAE-d..
A0A3N4SG66_9ACTN/240-289             LSDAALDTLV.DEIRHSEQP...PLSYREMATRFRTAGHSASEVRLRAAWKRV-----v..
A0A6G2S3G1_9ACTN/240-290             LSDEALDALV.DQIRHSEVP...ALSYREMATRFRAAGHSASEIRLRAAWKRLA----a..
A0A1Q5KZH5_9ACTN/235-286             LTDAALDRLV.DEIRTSQDP...ALSYREMATRFRAAGHSASEVRLRAAWKRVVA---a..
A0A3N6IDL9_9ACTN/237-288             LTDEALDALV.DQIRHSETP...ALSYREMATRFRAAGHSASEVRLRTAWKRVAA---a..
A0A1C4ID11_9ACTN/234-287             LTDGELDALV.AGIRVSRVP...VLSYREMASRFRSAGHSASEVRLRGAWKRVLAEE-t..
A0A941BUK0_9ACTN/237-287             LTDEALDLIV.DEIRTSETP...ALSYREMAARFRAAGHAASEMRLRAAWKRVA----a..
A0A6B3FH91_9ACTN/401-454             ISNEQIAVVL.RHLRYSDNP...PKSYRKSMAEFRAAGFVGSEERIRKVFSSLDED--as.
A0A9W7WRD2_TRIRA/163-215             LSDQELDMLV.SNI-KSEMP...HVGYRLMMGRLRSLGHRIQWSRLRASMHRIDAV--gv.
A0A291QB90_9ACTN/236-290             LTDTALDQLVeEEIRISEDP...ALSYRDMAARFRASGHSASEVRLRAAWKRVTS---ptp
L7FID8_9ACTN/237-287                 LTDQELDDLV.DTIRHSETP...ALSYREMAIRFRAAGHAASEVRLRAAWKRVA----a..
A0A171BGV5_9ACTN/235-291             LTDTDLEWIV.TDIIDTEAQkgrALSYREVATLFRAAGYSASETRLRAAWRRATGREE...
A0A9W7X2S8_TRIRA/149-201             LSDQELDMLV.SNI-KSEMP...HVGYRLMMGRLRSLGHRIQWSRLRASMHRIDAV--gv.
A0A6I6N7U3_9ACTN/295-348             LTDAQLVVVL.RHLRYSDDP...PLSYRQAVTAFREGGFVGGEQRVRKAWGSLMSHEE...
C9Z133_STRSW/237-287                 LTDGALGVLV.DEIRHSETP...ALSYREMSARFRAAGHSSSEMRLRAAWKRVV----a..
A0A919H3W2_9ACTN/299-352             LSDVQLVVVL.RHLRYSDDP...PLSYRQAVTAFRDAGFVGGEQRIRTAWGALMSQEE...
A0A066YR77_9ACTN/364-417             LTDVELDVVV.HMIRTETEP...PRSYREMEARFRELGYQGSAARLRAAWDRVATE--al.
A0A918FUW1_9ACTN/237-290             LSDAALDALV.DEIRHSETP...ALSYREMAIRFRAAGHSASEMRLRAAWKRVVA---yps
A0A8T4IY69_9ACTN/234-287             LTDEALDALV.VQIRDSEVP...PLSYRETASRFRAAGHAASEVRLRAAWKRVTTAA-p..
A0A918HI21_9ACTN/237-290             LSDAALDALV.DEIRHSETP...ALSYREMAIRFRAAGHSASEVRLRAAWKRVVA---yps
A0A8S3R8N7_MYTED/104-156             ICDDDLDQLL.QPI-KEENP...HIGYRSIQARLKVCGHFCQETRVREALVRLDPAA-v..
A0A918RVT2_9ACTN/236-289             LTDAALDGLV.DEIRHSQSP...ALSYRETAARFRAAGHSASEVRLRAAWKRVAAA--dr.
A0A3N6GV22_9ACTN/236-287             LTDEALDALV.DQIRHSETP...ALSYREMATRFRSAGHSASEVRLRTAWKRVVA---a..
#=GC seq_cons                        LTDstLDslV.ccIRaS-sP...sLSYRchusRFRuAGHuASEsRLRuAW+Rlh....s..
//