#=GF ID   PH_FAR1
#=GF AC   PF29445.1
#=GF DE   FAR1 PH domain
#=GF AU   Morveli N;0000-0003-2496-881X
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   ECOD:P21268_TED03
#=GF GA   27.00 27.00;
#=GF TC   27.30 27.20;
#=GF NC   26.90 26.60;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -E 1000 -Z 90746521 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0266
#=GF RC   Function description for P21268
#=GF RN   [1]
#=GF RM   8066461
#=GF RT   "Direct inhibition of the yeast cyclin-dependent kinase
#=GF RT   Cdc28-Cln by Far1.";
#=GF RA   Peter M., Herskowitz I.;
#=GF RL   Science 265:1228-1231(1994).
#=GF RC   Function description for P21268
#=GF RN   [2]
#=GF RM   7490290
#=GF RT   "FAR1 is required for oriented polarization of yeast cells in
#=GF RT   response to mating pheromones.";
#=GF RA   Valtz N., Peter M., Herskowitz I.;
#=GF RL   J. Cell Biol. 131:863-873(1995).
#=GF RC   Function description for P21268
#=GF RN   [3]
#=GF RM   9251033
#=GF RT   "Functional analysis of FAR1 in yeast.";
#=GF RA   Valtz N., Peter M.;
#=GF RL   Methods Enzymol. 283:350-365(1997).
#=GF RC   Function description for P21268
#=GF RN   [4]
#=GF RM   9367986
#=GF RT   "Phosphorylation- and ubiquitin-dependent degradation of the
#=GF RT   cyclin- dependent kinase inhibitor Far1p in budding yeast.";
#=GF RA   Henchoz S., Chi Y., Catarin B., Herskowitz I., Deshaies R.J.,
#=GF RA   Peter M.;
#=GF RL   Genes Dev. 11:3046-3060(1997).
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents a pleckstrin homology (PH) domain found in
#=GF CC   FAR1 and related cyclin-dependent kinase inhibitors. PH domains
#=GF CC   typically bind phosphoinositides and are involved in membrane
#=GF CC   localisation and protein-protein interactions. This PH domain is
#=GF CC   located in the C-terminal region of FAR1, which is required for
#=GF CC   oriented cell polarisation in response to mating pheromones [2].
#=GF CC   FAR1 functions as an inhibitor of the CDC28-CLN cyclin-dependent
#=GF CC   kinase complex and is essential for G1 cell cycle arrest during
#=GF CC   the mating response [1]. The domain is found in FAR1 orthologues
#=GF CC   across Saccharomycotina yeasts. The specific role of this PH
#=GF CC   domain in FAR1's mating functions remains to be determined.
#=GF SQ   60
#=GS C5E158_ZYGRC/454-582      AC C5E158.1
#=GS A0A1X7R9K5_9SACH/479-610  AC A0A1X7R9K5.1
#=GS G8B8T2_CANPC/309-436      AC G8B8T2.1
#=GS Q6FQH7_CANGA/436-574      AC Q6FQH7.1
#=GS A0A1E4TXN6_PACTA/384-520  AC A0A1E4TXN6.1
#=GS A0A8J5UYJ3_9ASCO/260-387  AC A0A8J5UYJ3.1
#=GS A0A1V2LCH0_CYBFA/201-331  AC A0A1V2LCH0.1
#=GS I2GWB4_HENB6/438-577      AC I2GWB4.1
#=GS G0VKB3_NAUCA/439-565      AC G0VKB3.1
#=GS A0A8H6F4S1_CANAX/122-247  AC A0A8H6F4S1.1
#=GS A0A9P8PQF2_9ASCO/333-460  AC A0A9P8PQF2.1
#=GS G8YEZ7_PICSO/230-359      AC G8YEZ7.1
#=GS M3JYD3_CANMX/216-346      AC M3JYD3.1
#=GS A0A1G4MH68_LACFM/479-607  AC A0A1G4MH68.1
#=GS A0A1D2VD72_9ASCO/378-518  AC A0A1D2VD72.1
#=GS A0A1E5RNE4_9ASCO/494-637  AC A0A1E5RNE4.1
#=GS A0A2U9QZD0_PICKU/361-493  AC A0A2U9QZD0.1
#=GS A0A1E4RRR5_9ASCO/257-390  AC A0A1E4RRR5.1
#=GS J7R3F3_HUIN7/416-551      AC J7R3F3.1
#=GS A0A1G4KBS1_9SACH/465-593  AC A0A1G4KBS1.1
#=GS A7TGQ6_VANPO/457-586      AC A7TGQ6.1
#=GS Q6BLG1_DEBHA/280-408      AC Q6BLG1.2
#=GS A0A9P0QNV4_9ASCO/238-375  AC A0A9P0QNV4.1
#=GS A0A642URB6_DIURU/197-343  AC A0A642URB6.1
#=GS C5MFU5_CANTT/285-406      AC C5MFU5.1
#=GS A5DCE9_PICGU/306-441      AC A5DCE9.2
#=GS G0W5I9_NAUDC/419-561      AC G0W5I9.1
#=GS A0A376B988_9ASCO/531-676  AC A0A376B988.1
#=GS G3AZK2_CANTC/377-507      AC G3AZK2.1
#=GS W1Q9J1_OGAPD/281-449      AC W1Q9J1.1
#=GS A0A448YRQ1_BRENA/1-153    AC A0A448YRQ1.1
#=GS A0A7H9HMK1_9SACH/438-565  AC A0A7H9HMK1.1
#=GS G8YCJ5_PICSO/230-360      AC G8YCJ5.1
#=GS A0A1D8PQH4_CANAL/181-306  AC A0A1D8PQH4.1
#=GS G3AVQ2_SPAPN/246-372      AC G3AVQ2.1
#=GS A0A1E3P5Y9_WICAA/322-451  AC A0A1E3P5Y9.1
#=GS A0A7H9AZ63_ZYGMR/453-584  AC A0A7H9AZ63.1
#=GS A3M0M2_PICST/270-396      AC A3M0M2.2
#=GS A5E749_LODEL/409-536      AC A5E749.1
#=GS A0A1E4SP32_9ASCO/298-425  AC A0A1E4SP32.1
#=GS K0KV34_WICCF/328-462      AC K0KV34.1
#=GS A0A421JCC1_9ASCO/310-445  AC A0A421JCC1.1
#=GS C4QVN4_KOMPG/362-492      AC C4QVN4.1
#=GS A0A421JNT0_9ASCO/131-251  AC A0A421JNT0.1
#=GS A0A1G4JCE7_9SACH/472-601  AC A0A1G4JCE7.1
#=GS A0A1E4TKT8_9ASCO/376-488  AC A0A1E4TKT8.1
#=GS A0A9P8TJ44_WICPI/388-516  AC A0A9P8TJ44.1
#=GS A0A9W4TZP1_9ASCO/270-396  AC A0A9W4TZP1.1
#=GS A0A367YIH8_9ASCO/275-402  AC A0A367YIH8.1
#=GS FAR1_YEAST/443-576        AC P21268.2
#=GS Q757W6_EREGS/446-578      AC Q757W6.2
#=GS A0AAI9SXA1_9ASCO/311-439  AC A0AAI9SXA1.1
#=GS C5DKI9_LACTC/473-599      AC C5DKI9.1
#=GS A0A875S8V8_EENNA/224-381  AC A0A875S8V8.1
#=GS A0A1E3QYT4_9ASCO/381-511  AC A0A1E3QYT4.1
#=GS I6ND08_ERECY/439-582      AC I6ND08.1
#=GS G8ZRW0_TORDE/433-560      AC G8ZRW0.1
#=GS A0A0C7MWS5_9SACH/470-604  AC A0A0C7MWS5.1
#=GS H2AWN1_KAZAF/432-558      AC H2AWN1.1
#=GS G8BN88_TETPH/428-577      AC G8BN88.1
C5E158_ZYGRC/454-582                 ..............FGSLSIFDQ.I.SYS.T.DGE.RWDENTLVCFFEKCLILF...............DLFEMKTI..GKI.PI.E.Q.VCHVNRL...SET.T..LIIDLKNR.TLPEIYFAFPPHL............R.NHKSVLE.......KW....KYYLM.........................................QPGR...........EPELE..fMSDTAWEIFPEDM.....APALM----givg.........................
A0A1X7R9K5_9SACH/479-610             .............e-SHLLMFDE.V.SYS.L.EGE.HWFEKTALFYFDGVLIII...............NKSKDNIC..GKI.PT.D.Q.ISSITKL...NEK.P.gLLICLKST.TLPEIYLQFNDHC............G.SDNMLLN.......KW....EYYLS.........................................HLEE...........KPPLYcdcISNTMFNTLPKVL.....KKEITTL--dl...........................
G8B8T2_CANPC/309-436                 ..............FGNLVIFDK.M.KIS.I.DGE.SWD-YSRVYLFSDYLVIY...............--NDNTLA..GMI.SI.S.N.DLSAASL...IDG.I..LNLNLTES.KLPELFLFN----............E.FSPTITQ.......KW....CYMLH.........................................KLMDne......qpiTNLFQ...FTSTCWLDYQY--.....---------emeipqnlirfnn................
Q6FQH7_CANGA/436-574                 ..............TGDLHMFSN.F.AFS.T.DGE.FWTQPILVFLFEKCLTLF...............EADSRNII..GQL.PV.N.Q.ISSTSELrhnNEE.I..IVIDLKSC.LFPQIFLKNHEVA............F.YKQEKIK.......KW....LYYLT.........................................DIGRv.........rPPLID...LTDCSINVIPIELsi.syEQ-------evlrqrinq....................
A0A1E4TXN6_PACTA/384-520             ..............LGELIIFDF.L.KIS.-.DGT.DWY-LAQCYLFENILLMV...............NEDGTSIN..GTV.MVkE.H.ISSVVET...DKR.IgsIMLNLKED.SLPILYISS----............-.ENRIINQ.......KW....FKYLS.........................................QIHKlskaktefnlkIPLIQ...ISTNAWSLVKDKDl...lPKEVI----lfnq.........................
A0A8J5UYJ3_9ASCO/260-387             ..............LGDLLMFDK.V.EVS.V.TGR.EWD-EATAYLFNQYFLLY...............--DEETLV..GVV.SL.E.D.DLTTVNA...EDR.M..LTLNLTKE.TLPELSVRFPST-............-.---VISV.......KW....DSAIN.........................................SLKNksn.....kvnYSLFE...FSGTFWKEFQ---.....---------dkfdipedlikftd...............
A0A1V2LCH0_CYBFA/201-331             ..........klpy---LRMFDC.F.DIS.L.DGS.VWE-YVYAFIFDETLILM...............NEELDSVI..GTV.LLgE.H.YTSCYKI...DNT.T..LVIYFSSA.SLPELQIHS----............-.QNKILLD.......KWveffEYKLR.........................................QKQM...........VPLVQ...MTTNTWDLIDDG-.....---------slelpseivkfnd................
I2GWB4_HENB6/438-577                 ...........ndd---VLLFDK.V.AYS.T.DGS.QWQYNCIAILFKSVIILY...............DIVLSSIE..GKI.PL.T.N.ISNISKL...NNK.T..LLMDVMST.ALPEVYFYFD--C............K.QNSHILE.......KW....KYCIK.........................................NIKKl........ktKTSLQ...LTETAWDIIPKSDv..ekQ--------adnkeelasankkela.............
G0VKB3_NAUCA/439-565                 ..............LGKLCIFEE.L.QFS.T.DDD.HWT-NVIGYLFSSYLLLI...............DVRTQLIV..GKI.PT.E.Q.ISKVTQI...TKG.N..LMIDLKST.VLPEIYLKFEGT-............S.VDQSLVD.......KW....KYYLE.........................................HRDE...........YPGLN..yVTSMSWTVLPETL.....VSEINKC--ia...........................
A0A8H6F4S1_CANAX/122-247             ..............VGQLVIFDI.L.EVS.V.TGK.SWD-SALVCLFENYFLIY...............--ENELLV..GII.SV.Q.H.DISSVDV...D-E.E..LILNLAKD.SLPELRLRH----............-.SNKLVVQ.......KW....GTLLL.........................................EIIDne.......svVTNIY..qLTNTYWTHLPPEIc...vPQNLTKL--nn...........................
A0A9P8PQF2_9ASCO/333-460             ............lp--QISLFDS.F.HIS.V.DGC.HWE-ITKSFLFNDFLIIL...............NNSMDGII..GTV.VI.S.N.HLTNLIV...QDD.I..IFLYFNTQ.TLPELQIKS----............-.SNKILSS.......KW....ANHLL.........................................NLKNd.........dLSLIK...MSTNLWDLIRFN-.....---------ndiqlpeeilkfsd...............
G8YEZ7_PICSO/230-359                 ..............LGSLWLFDQ.L.AIS.T.NGK.DWD-TVCVFLFSNVMLLV...............GEDLTEVI..GQI.RVqE.E.ICSINHY...E-Q.K..LYLNLVNE.ALPELQISH----............-.KSFVMLS.......KW....NHYLN.........................................CAIQgap.....scpTSLFQ...ITYNLWSLVPPELr...pQES------vqiyna.......................
M3JYD3_CANMX/216-346                 .............a-GELIVFDM.L.EIS.V.DGS.SWD-QTMACLFEEYLFFY...............D--HESLV..GMV.AI.K.Q.DISSLSR...SDN.V..IVFDLAKE.ALPELHMRH----............-.SHEVVVT.......KW....ERLLN.........................................KLIDgde.....dttTNLHQ...LTNTCWTTMEEYFd...iPPH------liklehtvk....................
A0A1G4MH68_LACFM/479-607             ..............LGQLELFDQ.V.EFS.S.DGD.NWT-LALGVLFNKCLAFS...............--QNGNIF..ACA.PI.S.E.VSGVHQM...DTH.T..LVFALKTK.SLPEIYLR----C............E.DGTLVVT.......KW....FNYLQlflp................................icrtiDTIN...........VPLGQ...VTTNMWNSLPHEL.....QKEVKE---rl...........................
A0A1D2VD72_9ASCO/378-518             ..............LGNLKMFDY.L.NFAlI.DGT.EYL-DAQCYLFEKYLLIL...............NNQGNSIT..GII.QI.KsD.LSSVIEL...NEN.T..ILLNSTIP.TLPEVDVY-----............S.EDKRIIS.......KW....KNYLKyssp.................................yidfKPKD...........VSLIS...LTTNAWDIIDQID.....---------sihhiipdyikeinnykr...........
A0A1E5RNE4_9ASCO/494-637             ............ei---LQMIDL.M.EVS.L.DDV.NYS-EWLLVMFENKIILKslktnk...sarnlqMGSLSSQV..INI.SN.K.E.LYSIMKC...KDK.T..F-VSLKSS.QIPELYMKN----............T.ENPIVLN.......KW....TVVMEyklgik.............................sannddK---...........-----...-------------.....---------ishfdksglnlsflhfttnafnlmqergl
A0A2U9QZD0_PICKU/361-493             ..............IGSLVVFDY.F.DVN.I.KTN.VFP-HTQVFLFDSCLIIL...............DSKGTQLL..LYQ.QL.D.D.RTFISSIy.eNNG.S..IIINLNSI.KLPSVTLSS----............-.ENKILLH.......KW....YIILG.........................................KFSEqvd....vsksIPLIQ...VSTNAWDLLED--.....---------apdetyadavped................
A0A1E4RRR5_9ASCO/257-390             ..............LGDLLLIDV.L.QVS.TtEGV.HWD-PLQCFCFTNGLIVY...............DNLSNSLI..GQI.IY.K.Q.DFKDLIF...DEN.K..IIIEFNNTdTIPELQLMS----............-.EIGLLSD.......KW....KYYLT.........................................KLLKqhl.....hfsIPLFQ...LTTTCWDSIIENL.....EVKL-----pselvkfse....................
J7R3F3_HUIN7/416-551                 .............a-AQLLMFDF.V.NYS.T.NGE.EWEKNVLLYYFQDVLIIY...............DDDNCKII..GKI.PI.N.Q.ISNAVTI...NEE.K..LLLDLKST.IVPEIYLQFTRTL............SsNSKFLTE.......KW....KYYLT.........................................YTQE...........IPSMM..qMTDTALSVLSSKM.....C--------dmfldwtrdkspan...............
A0A1G4KBS1_9SACH/465-593             ............sk--EVLLFDR.M.EFS.Q.DGD.TWA-EVEAYLFENNLAFF...............--QGTSIV..ADI.PL.D.Q.ISQLHPI...DAF.T..VVLNLKMK.SLHEAFINW----............H.GDARIMK.......KW....THYLK.........................................NASKrhma...ssvvVPLQD...FTTNGDSLLPDEI.....SN-------clragvg......................
A7TGQ6_VANPO/457-586                 ..............FGKLIMFDK.I.TYS.T.DGE.RWSDNIIAFLFTQYLVFY...............DSINKNVT..GKI.PL.D.Q.ISNINKL...KNR.M..MLIDLKTR.TLPEVYLLMPFT-............G.KDDDITS.......KW....KYYLQ.........................................NSNG...........FNELEfhiMTSTAWNFFPVNI.....YKEVQI---lle..........................
Q6BLG1_DEBHA/280-408                 ..............LGDLWMFDF.L.DIS.C.NGI.DWD-NISVYFFSHAIILV...............DNNGTRLM..GEV.LI.N.QdISSINRI...E-N.G..LILNLSNE.ALPELYMRH--T-............-.-CSLIIS.......KW....EYYLI.........................................QAVKnik.....tgqIPLLH...TTTNAWELLEES-.....---------nrsidglkfcn..................
A0A9P0QNV4_9ASCO/238-375             .............l-GGLIIFDI.F.DIN.I.NGN.DIG-DSEVYLFENGLIIM...............QGAQETCI..--L.QS.S.Q.FFTAVYS...SSN.E..IVLNLKSE.KIPEIKLTVEANYfg.......eyhI.EEWKIVE.......KW....LQIFDkii..................................sgedNLSS...........YCKFN..pITSNGWGMIPTDL.....RPHLDQI--dn...........................
A0A642URB6_DIURU/197-343             ............dt---LLCYDY.V.DIS.T.TSG.ALFDPIVAYLYANCMVFV...............--HHHSVI..GQV.QI.S.D.VAKVAAI...GS-.Q..LVVSLTTD.HLPELIFESH---............-.--PVAIV.......KW....EILLKrladsvaans.....................haslvqghdaK--Vve......vepLPLKQ...LTTNAWDYHPEVF.....---------dqwespelvefaeqv..............
C5MFU5_CANTT/285-406                 ..............VGELIMFDK.L.EIS.V.NGE.TWD-RITAYLFEDYLLLY...............--NTDILV..GML.SItS.D.ISSMDFI...NSK.C..LILNIAKE.SLPELQIR-----............S.SHEIIVT.......KW....ESFIS.........................................KLMKre......lvqSNIYQ...FTNTCW-------.....---------idlvdyfdipey.................
A5DCE9_PICGU/306-441                 .............l-STLILFDF.L.NIS.V.TGS.EWD-TLCCFLFDDRLLLV...............DFSKNEIV..GQL.SIhD.D.VASINK-...REN.G..ITLNLTQQ.GFPELQMC-----............H.SHPLICL.......KW....YTYFCr......................................vlA--Svsts...ivpsVPFNQ...LTTNGWYVLEDSF.....---------slipenaikvrtat...............
G0W5I9_NAUDC/419-561                 ..............CGSIIMIRR.V.KYS.T.DGE.QWTDSI-IYFYENYILLFdcn........fahnDLIEKKLL..GKI.PM.D.Q.LYKVTEF...NSN.E..LLLDLKST.VLPEVYLQFPSV-............-.FSETLSS.......KW....KYYLE.........................................KINNcdvkp.ieegcFPTLN..qLTVTAWDIIPISF.....IEKINQLY-s............................
A0A376B988_9ASCO/531-676             ...........wge--KIHMFDI.M.DVN.I.S-D.NWEENTIVILFDNFLTLL...............KLNNFENI..GKI.PI.N.E.ISRITFL..eDEN.T..IIIDLKSS.STPEILLK----H............E.FAGIIVK.......KW....AIYLQelvyn...............................ahletA--Kdsrg..gfnfkVPLIE...MTTNCLDILDPQI.....VD-------afpqgirtvle..................
G3AZK2_CANTC/377-507                 ..............LGKLVIFEI.I.GIS.T.NGT.NWD-QVRLLLFESCLILV...............DLKGEVLI..GKI.SI.D.QdILNMTRF...VS-.G..IRLDLNND.TIPELQICC----............-.EIPLIIS.......RL....EYFFK.........................................KLLEkqf.....vseTSLFQ...LTTNGWGLIKENY.....---------snlpvdiirfqn.................
W1Q9J1_OGAPD/281-449                 ..............LGHLVLFDIfV.SVS.I.DGN.SFH-HPQVYFFDRRLLIL...............NESGNELI..QNIyLM.D.K.LSTVFDD...ESNlE..ITLNLASL.SVPDVELKS----............-.ENKLIHD.......KW....LKLLSrivrraqrqpranpnnpfvaenpfderefspsnlfskeslsLSKE...........VPLIQ...MSTNAWGLLE---.....---------rnekvipeevlkfnk..............
A0A448YRQ1_BRENA/1-153               ..............MGKLVLFDQ.M.ENV.R.FNG.TSHENPLIFIFESVIVIL...............NSEASEIVlmQKV.NNeE.R.VSSVYAD..eTNN.S..IVVNFTTL.QLPEITFDT----............-.GNRILLQ.......KW....TKILKlfvertkgd......................dnhpfygrsaK--Stti.....gdfVPLIQ...VSTNSWNLLSDY-.....---------qdaipesirkfnk................
A0A7H9HMK1_9SACH/438-565             ..............LGSLVMFDR.G.DFS.T.DGE.GWNKGVILYLFDQFLILF...............DRQALTVR..GKI.PL.G.Q.ICQVLKL...DES.T..LLIDLKSR.TLPQVYMSFPPK-............V.TKNPQLE.......KW....RFYLG.........................................HIGS...........APSLE..dITRSSWDILPEEL.....VKDLNSF--fa...........................
G8YCJ5_PICSO/230-360                 ..............LGSLWLFDQ.L.AIS.T.NGK.DWD-TVCVFLFTNVMLLV...............GEDLGEVV..GQI.RV.QeE.ICSINH-...SEQ.K..LYLNLVNE.ALPELQIAH----............-.KSFLMLC.......KW....NHYLN.........................................CAIQgvs.....ncpTSPFQ...ITYNLWSLVPPEL.....RPQ------eseqiynam....................
A0A1D8PQH4_CANAL/181-306             ..............VGQLVIFDI.L.EVS.V.TGK.SWD-SALVCLFENYFLIY...............--ENELLV..GII.SV.Q.H.DISSVDV...D-E.E..LILNLAKD.SLPELRLRH----............-.SNKLVVQ.......KW....GTLLL.........................................EIIDne.......svVTNIY..qLTNTYWTHLPPEIc...vPQNLTKL--nn...........................
G3AVQ2_SPAPN/246-372                 ..............VGNLVMFDK.L.EVS.A.NGN.EWE-EVIAYLFESHLLFY...............D--GDSLA..GAI.AM.E.E.DMHNVNF...D-K.V..LTLNLTKE.TLPELSIKH----............-.DNPLVTT.......KW....EWVLNkvi..................................hnslNFSD...........INLFK...FSSTCW-------.....---------vdykdqfsldpdliefs............
A0A1E3P5Y9_WICAA/322-451             .............l-SKLRIFDF.V.EIS.L.DGY.NWE-FVQFFIFMNFLLIL...............NEEGDSII..GTI.MIkE.H.FSKLIKI...NDS.T..IILYFISS.TLPELQIRS----............-.NNKILIS.......KW....VDFFN.........................................NKLHkd.......seIPLIQ...MTTNGWDLIND--.....---------gtmgiplevvrfne...............
A0A7H9AZ63_ZYGMR/453-584             ..............VGSLLIFDA.I.DYS.T.DGE.QWIANIIAYLFQDILILF...............DHETMTTV..GKI.PM.K.Q.ICQVLKL...DRD.T..LLIDLKST.VLPEVYLSCRSF-............D.SKQSLME.......KW....MYYMS.........................................GGTE...........LPHLE..hITLTAWHILPVEI.....HSAIN----lhletlkq.....................
A3M0M2_PICST/270-396                 ..............LGNLVMFDN.L.YIS.T.NEV.EWD-IVKVFLFSKIILFS...............--RKDEMI..GKI.MIrE.D.ISSINKF...SG-.G..IILNLRNG.AIPEFYFRH----............-.TNPLIIA.......KW....ESIII.........................................QYFKwnk.....ldpLNRFQ...ITTNAFEIIPNVD.....---------fpedvrnlat...................
A5E749_LODEL/409-536                 ..............LGDLVIFDN.M.QIS.V.DGM.NWDDS-KIYLFSNYLLLY...............--NDKTLE..GMI.SIaD.D.LCSVTFY...-HG.I..LNLNLADG.ALPELNIRN----............K.LTDALTE.......KW....AFYLN.........................................QVRNqq......npeVSLFQ...FTSTCWLELQDEF.....---------eipsnlarfck..................
A0A1E4SP32_9ASCO/298-425             ............gd--DLIIFDH.L.HVS.T.NGH.DWD-GVCCFLFENILLLI...............--DGHKLI..GQV.LI.N.Q.DVRSVKA...TPN.G..VVLDLGDN.PVPQLHIRH----............-.DNPIVLS.......KW....ETMIQ.........................................KLLDhkp.....iayINMFQ...LSSNAWGLFKDCL.....---------diplevvefsh..................
K0KV34_WICCF/328-462                 ............fq--DLKIFDS.F.EIS.M.DGStNWE-KVQCFVFQKFILIL...............NSNGDEIL..GTI.IL.E.H.FHKIVQN...SNI.T..ITLIFSTQ.SVPELTIRS----............-.KNKILLT.......KW....FDYFD.........................................NKISsied...vttqIPIVQ...ITTNLWWLLDNDP.....---------qisipediikfne................
A0A421JCC1_9ASCO/310-445             .............l-STLILFDF.L.NIS.V.TGS.EWD-TLCCFLFDDRLLLV...............DFSKNEIV..GQL.SIhD.D.VASINK-...REN.G..ITLNLTQQ.GFPELQMC-----............H.SHPLICL.......KW....YTYFCr......................................vlA--Svsts...ivpsVPFNQ...LTTNGWYVLEDSF.....---------slipenalkvrtat...............
C4QVN4_KOMPG/362-492                 ..............LGTLLLFDI.F.QVG.V.DES.EWS-ELLIVFFERMLITM...............DIKGKQVV..GKV.AV.D.T.ISSITSQ...MED.T..IILNLTLL.SLPELILYS----............-.RDMTLID.......KW....KIVLQ.........................................KALKki......dqcIPLRS...LSLNGWSFLEDKS....lVPNLE----sqdlyqq......................
A0A421JNT0_9ASCO/131-251             ..hrtmieeleskn---------.-.---.-.---.-NQNSITAYLFDNYVLFY...............--DNDYLT..GAI.SI.E.NdIYNVNF-...-NE.A..LILNLTKE.ALPELLLRH----............-.QNGLVTD.......KW....EWALN.........................................HLLCsd......tphVNLFQ...LSSTCWEDYQEELa...iPQDLIS---fsn..........................
A0A1G4JCE7_9SACH/472-601             ..............TGTLEIFDV.L.RYS.E.DED.VWL-TVIVFLFQERLLFA...............--SEGSIV..RDI.SK.E.Q.ISELHQL...DPY.T..IILDLKSK.SLPEVFLG----C............G.EEPAVIR.......KW....FHCLKriy...................................lskE--Mq.........yIPLEQ...LTVNSWDLLPQDI.....AQSL-----rpkkigsf.....................
A0A1E4TKT8_9ASCO/376-488             nlricsmgraskdp---------.-.---.-.-QK.GWS-ETQLYLFESALVCL...............QHENNRLClrGVI.LV.S.QhLLSVVEI...NST.T..LKLKLSSA.GFEEFYLSFP---............-.-TNQLLS.......RW....SYALR.........................................FRH-...........-----...-------------.....---------asleeeveslsiqrykp............
A0A9P8TJ44_WICPI/388-516             ............lp--QLSLFDS.F.DIS.I.DGE.KWE-KTVNFLFGDSLVMF...............NDSLTHVI..GTV.LIsE.H.LISLILV...SDS.V..LVLYLSTQ.ALPELQIRS----............-.SNKVLLD.......RW....SRQLQ.........................................NLTN..........dVSLIK...MSTTLWSLIIH--.....---------egsqinlptnvikfne.............
A0A9W4TZP1_9ASCO/270-396             ..............LGELICFDN.L.NIS.I.DGL.NFE-NSIVYLFENYLIFY...............DLND-LPL..GMI.HK.S.D.FCNLNLI...EDN.I..LCLNLCKE.SLPELYLQ----H............E.FNNLIIS.......KW....EYLIN.........................................SMNEs........lhTNLYQ...FTSTMWIKYKEV-.....---------fqiskdlvkfnq.................
A0A367YIH8_9ASCO/275-402             ..............VGELVLFDK.L.EIS.V.NGE.TWD-ETIAYLFEDYLLLC...............--DNGVLI..GML.SV.TlD.ISSMYFV...NSH.C..LILNLAKE.SLPELHVRS----............-.SHEIVVC.......KW....EALLS.........................................KLMKrd......lqpSNIYQ...FTNTCWVDFE---.....---------ddfdipqylislnr...............
FAR1_YEAST/443-576                   ..............FGSLILFDK.L.MYS.D.DGE.QWVDNNLVILFSKFLVLF...............DFEEMKIL..GKI.PR.D.Q.FYQVIKF...NED.V..LLCSLKST.NIPEIYLRFNENC............-.-EKWLLP.......KW....KYCLE.........................................NSSLe.........tLPLSE...IVSTVKELSHVNI.....I--------galgappdvisaqs...............
Q757W6_EREGS/446-578                 ............ss--PLRLFDR.L.NYS.L.DGN.QWT-HVVVYCFEKCLLLVeq...........ehTDVEPVII..GKI.PM.E.H.LSRLYKY...NSN.T..IILDLKSI.SLPEVYLQD---L............K.GSAALIN.......KW....HFYLS.........................................NAQS..........rVPVAL...QTTNCWQLLPQHIld.kvPKELISYN-q............................
A0AAI9SXA1_9ASCO/311-439             ..............LGNLIIFDE.M.KIS.V.DGG.HWD-NSRLYLFENHLLFY...............--NDDVLA..GII.SI.E.N.DLCSMTF...SNG.I..LNLNLAEI.SLPELNIM----H............Q.VSDIITR.......KW....FYMLT.........................................QLKEk........lgVPNTNlfqFTSTCWIYLQHYF.....---------dissdlvrfnn..................
C5DKI9_LACTC/473-599                 ..............MGALETFDI.L.CYS.E.DEE.VWV-NVNAFLFSECLVFV...............--QEDNLV..GHI.LK.N.Q.ISEMHQL...DSH.T..LILNLKSK.SLPEIFLC----C............P.DDPSITR.......KW....TYYLR.........................................QVYLtrg.....gehVPLSQ...LTSNNWNFLPQKL.....IKKVR----ipse.........................
A0A875S8V8_EENNA/224-381             .............i-GKLVLLDY.MeKVR.F.NGE.DFYKEPLVILFESALVVL...............NNTASEVIlmQAI.DVdD.R.ISSVYAD..eANE.S..IIINFTIL.QLPEICFDT----............-.GSKIILQ.......KW....TKILKilmatansrdnd.................ssematfwqpqkA--Sav......snhIPLIQ...VSTNAWNILADYD.....---------edsipesvrkfn.................
A0A1E3QYT4_9ASCO/381-511             ..............FGDLIVLDS.F.ELS.V.DGK.KRD-PVQLYLFTKALLIL...............NPDSSAIL..GQI.NLtE.N.IVSLNKI...DDY.S..LIIDLRIS.PLLELHLYS----............-.KNPIVTH.......KW....ENLLT.........................................KRMLnig.....vrrLPLLQ...LTTNSWPFLKV--.....---------itglsnveipssv................
I6ND08_ERECY/439-582                 .............s-GKLRLFDR.L.QYS.L.DGN.QWT-PVVLYFFEKCLLLVqqgdsnfgdqddddqDTNTVRII..GKI.PM.N.Q.LSSFHKY...DPN.T..LILDLKSL.SFPEVYLQS---S............D.TSTGLIT.......KW....YFYLA.........................................NTEK..........eVPVVQ...QTTNCWSTLPSYIld.hiPKELISYN-q............................
G8ZRW0_TORDE/433-560                 ..............LGTLVMFDS.V.AYS.T.DGE.EWNENIMIYLFDQYLLLF...............DRDEMSTR..GKI.PM.K.Q.VCQVLKL...NDS.T..LLIDLKSR.ALPEVYICFPSD-............D.ARNSLLQ.......KW....KFYLG.........................................QSKE...........FPRLE..gITSTSWDILPEEL.....TLELKHL--wi...........................
A0A0C7MWS5_9SACH/470-604             ..............TGSLETFDK.M.SYS.E.DED.TWV-TVTAFMFQERLVLV...............--ADESLI..GNV.SR.D.Q.ISQLHQL...DPN.T..IIMNLKSK.LLPEIFLH----C............D.GDPAVIR.......KW....FYYLKrvfl.................................tpeeQSSS..........iVPLEQ...LTSNNWHFLPESMimpirPKSVES---yeg..........................
H2AWN1_KAZAF/432-558                 ..............IGKLLLFEK.C.KYS.V.EGE.EWSFNIIFCFYERLLILF...............DFSNEKIV..GRV.PV.D.R.VYDVTKI...SDL.K..ILIGMKST.ILPEMYIEF---C............G.PTEEKTA......lKW....KYYIE.........................................NLEK...........VPLLN..hITSSTTDFLPESL.....AVRFKSF--ak...........................
G8BN88_TETPH/428-577                 ..............YGELLMFDK.V.KYS.K.DGE.NWNSKITVLYFTKYLILF...............DNFEMKVS..GKL.PV.S.Q.IFQAKML...NHD.T..VIMDLMST.SVPEIYFCFDEGCnnsnsnssnnnnS.NSESLTDeinptalKW....KYYIE.........................................NAGKh........ieIPPQF...ITHNALDILSQDL.....QKNLVELK-a............................
#=GC seq_cons                        ..............hGpLllFDt.l.phS.h.-Gp.pWs.pshsaLFcshLllh...............s.psspll..GpI.sl.c.p.lsslhph...ssp.s..llLsLpsp.sLPElhlp...................psphllp.......KW....phhLp.........................................phhp...........lPlhp...lTossWshl.pph..............t............................
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