GenomeNet

Database: Pfam
Entry: PIP49_C
LinkDB: PIP49_C
Original site: PIP49_C 
#=GF ID   PIP49_C
#=GF AC   PF12260.10
#=GF DE   Protein-kinase domain of FAM69
#=GF AU   Assefa S;0000-0003-2178-533X
#=GF AU   Gavin OL;
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   PFAM-B_3196 (release 23.0)
#=GF GA   25.20 25.20;
#=GF TC   25.20 25.20;
#=GF NC   25.10 25.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0016
#=GF RN   [1]
#=GF RM   11281735
#=GF RT   Cloning and expression of the mouse PIP49 (Pancreatitis Induced
#=GF RT   Protein 49) mRNA which encodes a new putative transmembrane
#=GF RT   protein activated in the pancreas with acute pancreatitis.
#=GF RA   Samir AA, Ropolo A, Grasso D, Tomasini R, Dagorn JC, Dusetti N,
#=GF RA   Iovanna JL, Vaccaro MI;
#=GF RL   Mol Cell Biol Res Commun. 2000;4:188-193.
#=GF RN   [2]
#=GF RM   21334309
#=GF RT   Characterisation of the FAM69 family of cysteine-rich
#=GF RT   endoplasmic reticulum proteins.
#=GF RA   Tennant-Eyles AJ, Moffitt H, Whitehouse CA, Roberts RG;
#=GF RL   Biochem Biophys Res Commun. 2011;406:471-477.
#=GF DR   INTERPRO; IPR022049;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is the C-terminal region of a family of FAM69 proteins from
#=GF CC   Metazoa and Viridiplantae that are active protein-kinases. The
#=GF CC   family members have a short transmembrane helix close to the
#=GF CC   N-terminus, and thereafter are highly enriched with cysteines.
#=GF CC   FAM69 proteins are localised to the endoplasmic reticulum. Many
#=GF CC   members also have a short EF-hand, calcium-binding, domain just
#=GF CC   upstream of the kinase domain. The exact function of the more
#=GF CC   N-terminal family is uncertain.
#=GF SQ   2015
#=GS A0A3Q3NM20_9LABR/205-404    AC A0A3Q3NM20.1
#=GS A0A670I0H4_PODMU/62-238     AC A0A670I0H4.1
#=GS A0A2K6CPL8_MACNE/211-392    AC A0A2K6CPL8.1
#=GS A0A088A8I8_APIME/178-374    AC A0A088A8I8.1
#=GS A0A340WIR3_LIPVE/206-405    AC A0A340WIR3.1
#=GS G3SXE0_LOXAF/193-374        AC G3SXE0.1
#=GS A0A4U5PF42_STECR/292-477    AC A0A4U5PF42.1
#=GS A0A670HWK2_PODMU/141-321    AC A0A670HWK2.1
#=GS A0A2R9AKB6_PANPA/199-398    AC A0A2R9AKB6.1
#=GS L5LQD6_MYODS/127-326        AC L5LQD6.1
#=GS V8NFM5_OPHHA/184-386        AC V8NFM5.1
#=GS A0A2I3GE64_NOMLE/187-330    AC A0A2I3GE64.1
#=GS A0A2R8QS47_DANRE/149-350    AC A0A2R8QS47.1
#=GS A0A091X350_NIPNI/198-379    AC A0A091X350.1
#=GS A0A2T7NWP0_POMCA/198-385    AC A0A2T7NWP0.1
#=GS A0A060WD85_ONCMY/195-373    AC A0A060WD85.1
#=GS A0A2I3NGJ8_PAPAN/149-351    AC A0A2I3NGJ8.1
#=GS A0A401P040_SCYTO/183-385    AC A0A401P040.1
#=GS A0A1D2N818_ORCCI/203-407    AC A0A1D2N818.1
#=GS A0A6A5DQY9_PERFL/185-378    AC A0A6A5DQY9.1
#=GS F7DHI4_MONDO/181-382        AC F7DHI4.3
#=GS A0A2G9R4A0_LITCT/45-226     AC A0A2G9R4A0.1
#=GS A0A667Y6D5_9TELE/192-394    AC A0A667Y6D5.1
#=GS A0A5E4CD58_MARMO/212-393    AC A0A5E4CD58.1
#=GS A0A3Q0EJC3_CARSF/177-379    AC A0A3Q0EJC3.1
#=GS A0A182EI06_ONCOC/18-203     AC A0A182EI06.1
#=GS A0A0A0AZY6_CHAVO/177-379    AC A0A0A0AZY6.1
#=GS A0A6I8UWP8_DROPS/152-326    AC A0A6I8UWP8.1
#=GS A0A151J0J8_9HYME/194-390    AC A0A151J0J8.1
#=GS A7RRN9_NEMVE/193-381        AC A7RRN9.1
#=GS E1C167_CHICK/205-404        AC E1C167.2
#=GS W4YNX4_STRPU/160-247        AC W4YNX4.1
#=GS A0A672IZ02_SALFA/205-404    AC A0A672IZ02.1
#=GS A0A226PLE9_COLVI/317-423    AC A0A226PLE9.1
#=GS A0A341BCE7_NEOAA/169-371    AC A0A341BCE7.1
#=GS A0A3Q1CTT2_AMPOC/194-396    AC A0A3Q1CTT2.1
#=GS A0A2Y9JRJ3_ENHLU/211-392    AC A0A2Y9JRJ3.1
#=GS A0A1S3J434_LINUN/174-359    AC A0A1S3J434.1
#=GS G5BAR0_HETGA/121-316        AC G5BAR0.1
#=GS A0A2R8QGG9_DANRE/120-322    AC A0A2R8QGG9.1
#=GS A0A2K6G1Y0_PROCO/149-351    AC A0A2K6G1Y0.1
#=GS A0A5A9PD48_9TELE/205-404    AC A0A5A9PD48.1
#=GS A0A5E4C972_MARMO/95-297     AC A0A5E4C972.1
#=GS A0A2I0TKZ9_LIMLA/2-120      AC A0A2I0TKZ9.1
#=GS A0A2I0T434_LIMLA/97-299     AC A0A2I0T434.1
#=GS A0A672I418_SALFA/158-360    AC A0A672I418.1
#=GS M3YK90_MUSPF/206-405        AC M3YK90.1
#=GS A0A091I303_CALAN/1-118      AC A0A091I303.1
#=GS A0A4X2LXU3_VOMUR/180-381    AC A0A4X2LXU3.1
#=GS A0A401SLI5_CHIPU/185-388    AC A0A401SLI5.1
#=GS A0A484CZ47_PERFV/169-371    AC A0A484CZ47.1
#=GS A0A151NQH0_ALLMI/208-389    AC A0A151NQH0.1
#=GS G3GV29_CRIGR/1-132          AC G3GV29.1
#=GS A0A340Y4I0_LIPVE/110-312    AC A0A340Y4I0.1
#=GS A0A1A6G2P9_NEOLE/49-230     AC A0A1A6G2P9.1
#=GS A0A2K5PMZ5_CEBCA/206-405    AC A0A2K5PMZ5.1
#=GS A0A091HAF1_BUCRH/1-118      AC A0A091HAF1.1
#=GS K7F534_PELSI/179-380        AC K7F534.1
#=GS K7FI30_PELSI/204-386        AC K7FI30.1
#=GS A0A2U3W3I3_ODORO/149-351    AC A0A2U3W3I3.1
#=GS A0A671E2Y9_RHIFE/206-405    AC A0A671E2Y9.1
#=GS A0A3Q3XGS0_MOLML/140-349    AC A0A3Q3XGS0.1
#=GS U3I8J1_ANAPP/197-399        AC U3I8J1.2
#=GS A0A087V2S3_BALRE/122-323    AC A0A087V2S3.1
#=GS A0A673AI45_9TELE/214-416    AC A0A673AI45.1
#=GS A0A1S3ADH6_ERIEU/110-312    AC A0A1S3ADH6.1
#=GS G3QF08_GORGO/187-389        AC G3QF08.2
#=GS S9WDN1_CAMFR/165-367        AC S9WDN1.1
#=GS F1NEA9_CHICK/104-261        AC F1NEA9.4
#=GS A0A674CW81_SALTR/194-396    AC A0A674CW81.1
#=GS A0A3P9B5N2_9CICH/199-401    AC A0A3P9B5N2.1
#=GS A0A6I8P8B8_ORNAN/172-353    AC A0A6I8P8B8.1
#=GS B4QLH5_DROSI/167-357        AC B4QLH5.1
#=GS A0A3R7PVB5_PENVA/141-339    AC A0A3R7PVB5.1
#=GS A0A2I0UNR2_LIMLA/133-316    AC A0A2I0UNR2.1
#=GS A0A0V0TTC4_9BILA/211-320    AC A0A0V0TTC4.1
#=GS A0A3P6SRK0_LITSI/230-405    AC A0A3P6SRK0.1
#=GS S9XRN7_CAMFR/196-377        AC S9XRN7.1
#=GS A0A0L0C1Z9_LUCCU/74-263     AC A0A0L0C1Z9.1
#=GS A0A3Q0GZB8_ALLSI/45-195     AC A0A3Q0GZB8.1
#=GS A0A1V9Y1X5_9ACAR/261-342    AC A0A1V9Y1X5.1
#=GS A0A6A1Q907_BALPH/19-113     AC A0A6A1Q907.1
#=GS A0A4Z2EUN4_9TELE/1-88       AC A0A4Z2EUN4.1
#=GS A0A2A2J7J4_9BILA/194-379    AC A0A2A2J7J4.1
#=GS A0A2G8KQY4_STIJA/5-225      AC A0A2G8KQY4.1
#=GS A0A665TNK3_ECHNA/1-199      AC A0A665TNK3.1
#=GS A0A2K5Z6P6_MANLE/128-330    AC A0A2K5Z6P6.1
#=GS A0A5F4BRQ6_CANLF/151-353    AC A0A5F4BRQ6.1
#=GS A0A4W6C4Z0_LATCA/92-290     AC A0A4W6C4Z0.1
#=GS A0A5F4CS72_CANLF/1-86       AC A0A5F4CS72.1
#=GS A0A093HVY8_STRCA/196-377    AC A0A093HVY8.1
#=GS G1T3Q1_RABIT/67-266         AC G1T3Q1.2
#=GS A0A2P8Y8H6_BLAGE/1-170      AC A0A2P8Y8H6.1
#=GS A0A5J5CJ64_9PERO/1-167      AC A0A5J5CJ64.1
#=GS A0A0V1HPJ9_9BILA/209-359    AC A0A0V1HPJ9.1
#=GS M3VZS6_FELCA/191-372        AC M3VZS6.3
#=GS A0A2R9BES5_PANPA/211-392    AC A0A2R9BES5.1
#=GS A0A5N5N6L2_PANHP/155-345    AC A0A5N5N6L2.1
#=GS J9L8H2_ACYPI/191-394        AC J9L8H2.2
#=GS A0A091RYC8_9GRUI/131-333    AC A0A091RYC8.1
#=GS A0A093Q541_9PASS/185-387    AC A0A093Q541.1
#=GS A0A4W4EHV6_ELEEL/158-360    AC A0A4W4EHV6.1
#=GS L8I5H8_9CETA/65-247         AC L8I5H8.1
#=GS A0A455BV96_PHYMC/196-378    AC A0A455BV96.1
#=GS A0A2K6S7I6_SAIBB/152-334    AC A0A2K6S7I6.1
#=GS A0A2R8QL49_DANRE/209-391    AC A0A2R8QL49.1
#=GS C3ZED3_BRAFL/195-394        AC C3ZED3.1
#=GS R0K9H2_ANAPL/197-376        AC R0K9H2.1
#=GS A0A2Y9E535_TRIMA/188-385    AC A0A2Y9E535.1
#=GS A0A671FWF8_RHIFE/197-399    AC A0A671FWF8.1
#=GS A0A1V4JYL8_PATFA/194-396    AC A0A1V4JYL8.1
#=GS A0A673CYR7_9TELE/205-404    AC A0A673CYR7.1
#=GS A0A553QH94_9TELE/283-485    AC A0A553QH94.1
#=GS A0A087R4Q4_APTFO/177-379    AC A0A087R4Q4.1
#=GS A0A2K5NRR2_CERAT/206-405    AC A0A2K5NRR2.1
#=GS A0A3P7M807_9BILA/120-174    AC A0A3P7M807.1
#=GS A0A226PSP4_COLVI/251-450    AC A0A226PSP4.1
#=GS A0A3Q3VWL7_MOLML/189-391    AC A0A3Q3VWL7.1
#=GS A0A4X2K218_VOMUR/210-391    AC A0A4X2K218.1
#=GS A0A2U9CWQ9_SCOMX/205-404    AC A0A2U9CWQ9.1
#=GS A0A437C7K0_ORYJA/205-404    AC A0A437C7K0.1
#=GS A0A2Y9JQZ5_ENHLU/206-405    AC A0A2Y9JQZ5.1
#=GS A0A672TLV3_STRHB/179-380    AC A0A672TLV3.1
#=GS A0A484C1B7_PERFV/205-404    AC A0A484C1B7.1
#=GS A0A4W4EGN6_ELEEL/201-409    AC A0A4W4EGN6.1
#=GS G3SUG4_LOXAF/48-241         AC G3SUG4.1
#=GS C3Z3A2_BRAFL/73-205         AC C3Z3A2.1
#=GS A0A0B1S2N4_OESDE/133-183    AC A0A0B1S2N4.1
#=GS A0A5A9N4F3_9TELE/201-409    AC A0A5A9N4F3.1
#=GS A0A1S3A2E0_ERIEU/211-392    AC A0A1S3A2E0.1
#=GS A0A2K6JTQ7_RHIBE/206-405    AC A0A2K6JTQ7.1
#=GS A0A3Q3BTY1_HAPBU/194-396    AC A0A3Q3BTY1.1
#=GS A0A1R3GQN2_COCAP/403-524    AC A0A1R3GQN2.1
#=GS H3BBY5_LATCH/122-325        AC H3BBY5.1
#=GS A0A3N0YFF4_ANAGA/150-340    AC A0A3N0YFF4.1
#=GS A0A4W2F992_BOBOX/206-405    AC A0A4W2F992.1
#=GS A0A1D5QJ74_MACMU/206-405    AC A0A1D5QJ74.2
#=GS G1KCN5_ANOCA/194-396        AC G1KCN5.2
#=GS A0A093R420_PYGAD/131-333    AC A0A093R420.1
#=GS A0A1S3J7I3_LINUN/247-459    AC A0A1S3J7I3.1
#=GS A0A3P9PI74_POERE/199-401    AC A0A3P9PI74.1
#=GS U3J980_ANAPP/180-382        AC U3J980.2
#=GS A0A091RER1_9GRUI/46-227     AC A0A091RER1.1
#=GS A0A2K6NGP5_RHIRO/206-405    AC A0A2K6NGP5.1
#=GS A0A3Q1ITG6_ANATE/138-359    AC A0A3Q1ITG6.1
#=GS A0A3L8T0N4_CHLGU/265-466    AC A0A3L8T0N4.1
#=GS A0A096MKT4_PAPAN/194-396    AC A0A096MKT4.1
#=GS A0A452HMW5_9SAUR/14-161     AC A0A452HMW5.1
#=GS A0A670IGI8_PODMU/194-396    AC A0A670IGI8.1
#=GS A0A670KG09_PODMU/206-408    AC A0A670KG09.1
#=GS A0A3Q2VGP9_HAPBU/230-432    AC A0A3Q2VGP9.1
#=GS A0A182YR11_ANOST/220-409    AC A0A182YR11.1
#=GS G1NWA3_MYOLU/223-306        AC G1NWA3.1
#=GS A0A4W3HJ42_CALMI/180-382    AC A0A4W3HJ42.1
#=GS A0A2K5ZQR6_MANLE/205-407    AC A0A2K5ZQR6.1
#=GS A0A151XEC2_9HYME/25-210     AC A0A151XEC2.1
#=GS E2A934_CAMFO/178-374        AC E2A934.1
#=GS A0A3Q0DI87_CARSF/314-512    AC A0A3Q0DI87.1
#=GS A0A0B2VKA9_TOXCA/14-198     AC A0A0B2VKA9.1
#=GS A0A093IJ66_EURHL/1-118      AC A0A093IJ66.1
#=GS H3A422_LATCH/205-404        AC H3A422.1
#=GS A0A3S1BAU3_ELYCH/219-416    AC A0A3S1BAU3.1
#=GS A0A5J5CT26_9PERO/208-410    AC A0A5J5CT26.1
#=GS A0A1S3Q9N1_SALSA/196-393    AC A0A1S3Q9N1.1
#=GS A7SI84_NEMVE/135-325        AC A7SI84.1
#=GS A0A4W5PWI1_9TELE/179-376    AC A0A4W5PWI1.1
#=GS A0A6J3RKU8_TURTR/190-392    AC A0A6J3RKU8.1
#=GS A0A452E7H5_CAPHI/191-373    AC A0A452E7H5.1
#=GS A0A091SWJ6_NESNO/178-380    AC A0A091SWJ6.1
#=GS A0A091UQQ3_NIPNI/177-379    AC A0A091UQQ3.1
#=GS A0A5N3XZ14_MUNRE/181-377    AC A0A5N3XZ14.1
#=GS A0A5F4DBY2_CANLF/278-448    AC A0A5F4DBY2.1
#=GS A0A3P8ZHF7_ESOLU/152-349    AC A0A3P8ZHF7.1
#=GS A0A1S3LVQ9_SALSA/199-401    AC A0A1S3LVQ9.1
#=GS A0A226PLE9_COLVI/179-294    AC A0A226PLE9.1
#=GS H0YYV2_TAEGU/196-377        AC H0YYV2.2
#=GS A0A091SX04_PELCR/131-333    AC A0A091SX04.1
#=GS A0A667Y6F3_9TELE/194-396    AC A0A667Y6F3.1
#=GS A0A2F0BLJ2_ESCRO/227-348    AC A0A2F0BLJ2.1
#=GS DIK1A_PONAB/194-396         AC Q5R634.1
#=GS A0A3P4RZX8_GULGU/199-400    AC A0A3P4RZX8.1
#=GS A0A452R3X3_URSAM/149-330    AC A0A452R3X3.1
#=GS A0A2K6MPW9_RHIBE/197-399    AC A0A2K6MPW9.1
#=GS A0A5N4AKJ8_PHOPY/110-222    AC A0A5N4AKJ8.1
#=GS A0A2K6GZS7_PROCO/199-380    AC A0A2K6GZS7.1
#=GS A0A0P7W9J0_SCLFO/156-364    AC A0A0P7W9J0.1
#=GS A0A091GKK2_9AVES/177-379    AC A0A091GKK2.1
#=GS A0A226N594_CALSU/178-326    AC A0A226N594.1
#=GS A0A673V495_SURSU/211-392    AC A0A673V495.1
#=GS U3ITS6_ANAPP/209-390        AC U3ITS6.2
#=GS A0A4X2JP26_VOMUR/194-396    AC A0A4X2JP26.1
#=GS A0A0D9RTM5_CHLSB/197-399    AC A0A0D9RTM5.1
#=GS A0A3B3I2S3_ORYLA/159-358    AC A0A3B3I2S3.1
#=GS A0A2Y9NII1_DELLE/235-437    AC A0A2Y9NII1.1
#=GS A0A556TU61_BAGYA/85-287     AC A0A556TU61.1
#=GS A0A452ITG8_9SAUR/179-380    AC A0A452ITG8.1
#=GS A0A0N4TYD6_BRUPA/258-443    AC A0A0N4TYD6.2
#=GS A0A2R9BIN7_PANPA/152-334    AC A0A2R9BIN7.1
#=GS A0A2Y9NZK8_DELLE/206-405    AC A0A2Y9NZK8.1
#=GS A0A3Q3RWD3_9TELE/169-371    AC A0A3Q3RWD3.1
#=GS A0A3M6UND8_9CNID/1-92       AC A0A3M6UND8.1
#=GS A0A674HHE3_TAEGU/228-390    AC A0A674HHE3.1
#=GS A0A2Y9M1W9_DELLE/183-380    AC A0A2Y9M1W9.1
#=GS A0A3Q4ATH8_MOLML/194-396    AC A0A3Q4ATH8.1
#=GS A0A2K5DZG7_AOTNA/147-349    AC A0A2K5DZG7.1
#=GS A0A2T7PE46_POMCA/220-392    AC A0A2T7PE46.1
#=GS A0A3L8SPC9_CHLGU/194-396    AC A0A3L8SPC9.1
#=GS A0A4W3JUN5_CALMI/189-391    AC A0A4W3JUN5.1
#=GS A0A3Q7VJL1_URSAR/185-385    AC A0A3Q7VJL1.1
#=GS A0A091D0F2_FUKDA/185-387    AC A0A091D0F2.1
#=GS W5P3J5_SHEEP/71-215         AC W5P3J5.1
#=GS A0A087QMN5_APTFO/171-373    AC A0A087QMN5.1
#=GS A0A164U4Y5_9CRUS/273-487    AC A0A164U4Y5.1
#=GS A0A1L8F9V9_XENLA/155-334    AC A0A1L8F9V9.1
#=GS T1KCC1_TETUR/57-271         AC T1KCC1.1
#=GS A0A2K6P1S1_RHIRO/186-388    AC A0A2K6P1S1.1
#=GS A0A3Q3H0K1_9LABR/210-412    AC A0A3Q3H0K1.1
#=GS A0A2Y9JIL7_ENHLU/197-398    AC A0A2Y9JIL7.1
#=GS A0A183ADP1_9TREM/653-726    AC A0A183ADP1.1
#=GS A0A3P9PFV8_POERE/218-420    AC A0A3P9PFV8.1
#=GS A0A1S3FCQ3_DIPOR/169-371    AC A0A1S3FCQ3.1
#=GS A0A3B0K9Y4_DROGU/167-357    AC A0A3B0K9Y4.1
#=GS R7T451_CAPTE/131-325        AC R7T451.1
#=GS A0A5N4EJZ4_CAMDR/206-414    AC A0A5N4EJZ4.1
#=GS A0A093QU06_PYGAD/171-373    AC A0A093QU06.1
#=GS A0A4D9EBC4_9SAUR/194-396    AC A0A4D9EBC4.1
#=GS A0A3Q3N6N3_9TELE/199-401    AC A0A3Q3N6N3.1
#=GS K7GD28_PELSI/73-272         AC K7GD28.1
#=GS A0A4U5UHS4_COLLU/253-455    AC A0A4U5UHS4.1
#=GS A0A484CEJ2_PERFV/198-400    AC A0A484CEJ2.1
#=GS A0A2U3ZDR1_ODORO/1-167      AC A0A2U3ZDR1.1
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U3JG80_FICAL/191-393                   .....................................................AWALLQ.......LE.EFL....LMV..ILQD...K.E....-HTPKLIGFC.........G....D....L....Y...V.T.ER.VEYTSLYGIslpwiie...........................................llipsgfRRSMDQ.W.F..T.PSW...P..RK....A..KI.AIGLLE.FVED...I.......F.....HG..........PY...............GN...FLMCDT.....S.....A.KNLG..YN.....DK.......Y..D...L..KM..MDMRKIV.PEIN..L...KEI.IK..D.RQCDS........D.............................LDCIY....gT......DCR....T...L...C......D..Q...S.KM..R..CT..TEVI..QPN..LAKA.CQL..L........KDYL..................................L.R.GA.........PS......DIHEE....LEKQLYLCIA-l...........................................................
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H9J4A7_BOMMO/1-122                     ....................................................m------.......--.---....---..----...-.-....----------.........-....-....-....-...-.-.--.---------.........................................................------.-.-..-.---...-..--....-..--.------.---D...F.......T.....FK..........HD...............RF..rFYIMDW.....S.....T.DNIV..AN.....ER.......D..E...V..TF..VDLEDVI.ILDK..H...--I.SP..K.KDLPH........W............................yQRYIH....dI......DGP....G...F...V......F..S...I.EN..M..CK..HHLS..DHN..IWAA.CYV..L........AGEEa................................yL.Y.PI.........PS......QVNASr.phLDKLLNKCLN-g...........................................................
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H0UY21_CAVPO/38-232                    .....................................................AWSLLQ.......QE.EYV....YFS..LLQD...L.S....RHVLPVLGSC.........G....H....F....Y...V.V.EY.LAAGSPHHS........................................................aLFPLDE.S.G..R.AQD...K..AI....S..RI.ALSFLD.MVSH...F.......E.....ND..........FS...............HR...LHLCDI.....K.....P.ENFA..IR.....SD.......F..T...V..VA..IDVDMAF.FEPK..M...REI.L-..E.QNCTG........D.............................EDCNF.....F......DCF....S...K...C......D..L...R.IN..R..CG..AQRV..NSN..LQVI.CDK..I........FHRW..................................F.C.SS.........PRspavswPLRLQ....LQQAVRECA--gs..........................................................
L5KHS0_PTEAL/175-361                   .....................................................LWSLLQ.......QE.EFV....LLS..LLQG...L.S....RHALPVLGSC.........G....H....F....Y...A.V.EY.LAAGSPRHS........................................................aLFPLDG.A.S..R.SQA...Q..AV....S..DM.ALSFLD.LVSH...F.......D.....ND..........FS...............HR...LHLCDV.....K.....P.ENFA..IR.....RD.......F..T...V..VA..IDVDMAF.FEPK..M...REI.L-..E.QNCTG........D.............................EDCNF.....F......DCF....S...K...C......D..L...R.VN..K..CG..AQRV..NSN..LQVH.---..-........----..................................-.-.--.........--......-----....-----------sprlpgevlrlpcgdrlepyqpnisfvl................................
G3NHT7_GASAC/205-405                   .....................................................LMTLAF.......NP.EPL...vLTQ..SFPS...D.E...gWPFAKYLGAC.........G....R....M....V...A.V.NY.VGE-ELW--.........................................................-----S.F.Y..N.APW...E..KR....V..DL.ARQLMD.IAEQ...L.......T.....NN..........DF...............DF..aLYLLDV.....S.....F.DNFA..VG....pRD.......G..K...V..IV..VDAENVL.VADK..-...-RL.IK..Q.NKPES.......fDvwy......................esrfEECDR.....E......ACL....S...F...S......K..-...-.ES..L..CS..RVTV..DHN..YYAV.CQN..L........LSRYatwrg........................ttgglL.H.DP.........PA......HIAKDg..qLLTLLDECTRP............................................................
A0A493TAH6_ANAPP/190-392               .....................................................IWALLQ.......LN.EFL....LLL..SLHE...K.E....-HTAKLLGYC.........G....D....L....Y...V.T.EK.IPHSSLYGTdvppflq...........................................pllptalQRVLHQ.W.V..A.PAW...P..RR....A..KI.SIGLLE.FVEE...I.......F.....HG..........TY...............GN...FYICET.....S.....V.GNVG..YN.....EK.......Y..D...F..KM..VNLRKVA.TEMA..I...RGF.LK..G.RHCEQ........N.............................VDCTY....gQ......DCT....A...T...C......D..K...L.LK..Q..CK..GDVV..QPN..LAKV.CGL..L........QDYL..................................L.Y.GA.........PL......ELKDE....LQKQLRTCMT-l...........................................................
A0A2I3RWH9_PANTR/110-312               .....................................................VWALLQ.......RN.EFL....LLL..SLQE...K.E....-HASRLLGYC.........G....D....L....Y...L.T.EG.VPHGAWHAAalppllr...........................................pllppalQGALQQ.W.L..G.PAW...P..WR....A..KI.AIGLLE.FVEE...L.......F.....HG..........SY...............GT...FYMCET.....T.....L.ANVG..YT.....AT.......Y..D...F..KM..ADLQQVA.PEAT..V...RRF.LQ..G.RRCEH........S.............................ADCTY....gR......DCR....A...P...C......D..R...L.MR..Q..CK..GDLI..QPN..LAKV.CAL..L........RGYL..................................L.P.GA.........PA......DLREE....LGTQLRTCTT-l...........................................................
L5MHI7_MYODS/193-374                   .....................................................LYTLAV.......NA.HPI....LLQ..IFPG...A.E...gWPLPKYLGSC.........G....R....F....L...V.S.SS.TS-------.........................................................--PLQE.F.Y..A.APP...D..QA....A..DL.AHQLLR.ILES...L.......R.....NN..........DL...............NY..fLYFTHV.....D.....A.SMFG..IF.....NN.......G..H...L..FI..RDASALG.VIDR..Q...EGS.QA..A.ARAAE........N.............................KD--I.....F......SCL...vT...G...C......Q..A...E.LP..S..CD..SIPE..KQS..LVLV.CRQ..V........LPQL..................................L.Q.GK........fPS......PVQEQ....IDVLLAKCG--eg..........................................................
A0A4D9E5F6_9SAUR/209-323               .....................................................LYTLSV.......NA.HPI....LLQ..IFPE...A.E...gWPFPKYLGSC.........G....R....L....I...V.T.AS.TR-------.........................................................--PLKE.F.Y..S.SLP...E..VA....A..DL.ALQLLS.IVNA...M.......R.....NN..........DM...............NY..fFYFVHV.....D.....A.GTFG..IF.....NN.......G..L...L..FI..RDASTLG.IIDK..Q...EG-.--..-.-----........-.............................-----.....-......---....-...-...-......-..-...-.--..-..--..----..---..----.---..-........----..................................-.-.--.........--......-----....-----------tqyd........................................................
A0A096NRR9_PAPAN/197-399               .....................................................VWALLQ.......RN.EFL....LLL..SLQE...K.E....-HASRLLGYC.........G....D....L....Y...L.T.EG.VPHGAWHAAalppllr...........................................pllppalQGALQQ.W.L..G.PAW...P..WR....A..KI.AIGLLE.FVEE...L.......F.....HG..........SY...............GT...FYMCET.....T.....L.ANVG..YT.....AT.......Y..D...F..KM..ADLQQVA.PEAT..V...RRF.LQ..G.RRCEH........S.............................TDCTY....gR......DCR....A...P...C......D..R...L.MR..Q..CK..GDLI..QPN..LAKV.CAL..L........RGYL..................................L.P.GA.........PA......DLREE....LGTQLRTCTT-l...........................................................
A0A662YV38_ACIRT/185-387               ....................................................t-WALLQ.......LN.EFL....LMI..ILQD...K.E....-HTPKLLGFC.........G....N....L....Y...V.M.EK.VQYTSLYGIsipwime...........................................lfvpsgaRRSMDQ.W.F..T.PSW...P..RK....A..KI.SIGLLE.FVED...I.......F.....HG..........TF...............GN...FLMCDT.....S.....A.NNFG..YN.....AK.......H..D...L..KM..VDMRKIV.PEVS..F...KDL.IR..D.HHCET........D.............................EDCVY....gM......DCR....T...T...C......D..Q...T.KK..K..CT..TEVI..QPN..LAKA.CQS..L........KDYL..................................L.R.GA.........PP......EIREE....LEKQLYSCIA-l...........................................................
A0A3Q3AGN6_CHICK/205-404               .....................................................LITLAF.......NP.EPL....VLQ..SFPS...D.E...gWPFAKYLGAC.........G....R....M....V...A.V.NY.VGE-ELW--.........................................................-----S.Y.F..N.APW...E..KR....V..DL.AWQLME.IAEQ...L.......T.....NN..........DF...............EF..aLYLLDV.....S.....F.DNFA..VG....pRD.......G..K...V..II..VDAENVL.VADK..-...-RL.IR..Q.NKPEN........Wdvwy.....................eskfDDCDK.....E......ACL....S...F...S......K..-...-.EI..L..CA..RVTV..DHN..YYAV.CQN..L........LSRHatwrg........................tsgglL.H.DP.........PA......DIAKDg..rLEALLDECANP............................................................
A0A1U7TQJ6_CARSF/1-167                 ....................................................m------.......--.---....---..----...-.-....----------.........-....-....-....V...A.V.NY.VGE-ELW--.........................................................-----S.Y.F..N.APW...E..KR....V..DL.AWQLME.IAEQ...L.......T.....NN..........DF...............EF..aLYLLDV.....S.....F.DNFA..VG....pRD.......G..K...V..II..VDAENVL.VADK..-...-RL.IR..Q.NKPEN........Wdvwy.....................eskfDDCDK.....E......ACL....S...F...S......K..-...-.EI..L..CA..RATV..DHN..YYAV.CQN..L........LSRHatwrg........................tsgglL.H.DP.........PS......EIAKDg..rLEALLDECANP............................................................
A0A2K5X6R1_MACFA/194-396               .....................................................AWALLQ.......LN.EFL....LMV..ILQD...K.E....-HTPKLMGFC.........G....D....L....Y...V.M.ES.VEYTSLYGIslpwvie...........................................lfipsgfRRSMDQ.L.F..T.PSW...P..RK....A..KI.AIGLLE.FVED...V.......F.....HG..........PY...............GN...FLMCDT.....S.....A.RNLG..YN.....DK.......Y..D...L..KM..VDMRKIV.PETN..L...KEL.IK..D.RHCES........D.............................LDCVY....gT......DCR....T...S...C......D..Q...S.TM..K..CT..SEVI..QPN..LAKA.CQL..L........KDYL..................................L.R.GA.........PS......EIREE....LEKQLYSCIA-l...........................................................
A0A2R9CLK9_PANPA/128-330               .....................................................AWALLQ.......LN.EFL....LMV..ILQD...K.E....-HTPKLMGFC.........G....D....L....Y...V.M.ES.VEYTSLYGIslpwvie...........................................lfipsgfRRSMDQ.L.F..T.PSW...P..RK....A..KI.AIGLLE.FVED...V.......F.....HG..........PY...............GN...FLMCDT.....S.....A.KNLG..YN.....DK.......Y..D...L..KM..VDMRKIV.PETN..L...KEL.IK..D.RHCES........D.............................LDCVY....gT......DCR....T...S...C......D..Q...S.TM..K..CT..SEVI..QPN..LAKA.CQL..L........KDYL..................................L.R.GA.........PS......EIREE....LEKQLYSCIA-l...........................................................
A0A667XQW1_9TELE/172-374               .....................................................MWALLQ.......LN.EFL....LAL..VLQD...R.E....-HTPKLLGFC.........G....D....L....Y...V.V.EK.VPYSPLYGIslpwvie...........................................lwipaglRRSMDQ.W.F..T.PSW...P..RK....A..KI.SIALLE.LVED...I.......F.....HG..........TF...............GS...FLMCDV.....S.....A.TNFG..YN.....DR.......H..D...L..KV..LDARYIV.PEAS..F...QEG.MR..E.RRCDV........D.............................EDCLY....gV......DCH....T...S...C......D..L...T.KH..R..CT..PEVT..RPN..LAKA.CSA..L........KDYI..................................L.R.GA.........PS......DMSEE....LEKQLYACIA-l...........................................................
A0A1V4JCJ8_PATFA/192-373               .....................................................LYTLSV.......NS.HPI....LLQ..IFPD...V.E...gWPFPRYLGSC.........G....R....L....V...V.S.AS.TR-------.........................................................--PLRD.F.F..S.SAP...E..VS....A..DL.ALQLLA.VLRS...M.......G.....TN..........DL...............NY..fFYFTHV.....D.....G.GTFG..VF.....SN.......G..H...L..FI..RDASTLG.IIDK..E...EGS.QL..I.DDQQE........Y.............................KD--I.....F......SCL....T..vD...C......Q..S...A.FV..S..CD..SIGE..KHS..LVMV.CQE..L........LPKL..................................L.N.GK........fLQ......PVQGQ....IDSFLQHCAD-g...........................................................
A0A182YE53_ANOST/179-388               ................................................nllav----RT.......NV.EPL....LLK..LFAT...H.Dt.ssLYVPKLLDMI.........G....F....T....-...V.I.ES.YE-GQT---.........................................................---LEH.Y.Y..D.QPL...A..IR....L..LI.AAKLIQ.AAFS...F.......T.....EG..........IH...............GF..rFYLTDI.....N.....P.DNVV..VKvdhgnSN.......V..R...V..SI..VDLDNVI.ILDS..L...AGT.FS..S.QHAYH.......vH.............................GKIEC.....N......GCF....A...Y...V......Q..-...-.ED..V..CR..YRSS..DLN..LFAT.CQL..L........LENLngnyaagllh..............sghskskdqsL.T.DP.........YD......DAPQI....LHNLLEECV--hc..........................................................
A0A4W5RZZ8_9TELE/196-398               .....................................................AWALLQ.......LD.EVL....LGL..LLQD...R.G....-HTPRLLGFC.........G....D....L....Y...V.T.ER.VPYGPLYGLslpwple...........................................awvpseaRRSMDQ.W.F..T.PSW...P..RK....A..KI.SMGLLE.LVED...I.......F.....HG..........TY...............GS...FLMCDL.....S.....A.NHFG..YT.....DR.......H..D...L..RL..TDPRAIV.SEDA..F...RRT.MR..A.LHCEK........D.............................DDCVL....gP......DCR....T...S...C......D..M...A.QR..R..CR..EEVT..QPN..LAKV.CGA..L........RDYL..................................L.R.GA.........PS......ELREE....LERQLYACIA-l...........................................................
A0A498LUN3_LABRO/205-421               .....................................................LMTLAF.......NP.EPL....VLQ..SFPS...D.E...gWPFAKYLGAC.........G....R....M....V...A.V.NY.VGE-ELW--.........................................................-----S.F.F..N.APW...E..KR....V..DL.AKQLMD.IAEQ...L.......T.....NN..........DF...............DF..aLYLLDV.....S.....F.DNFA..VG....pRD.......G..K...V..IV..VDAENVV.VADKrlI...KQK.SQ..G.RYPTS........Drtlfreqdkp........enydiwyeskfEECDK.....E......ACL....S...F...S......K..-...-.DM..L..CS..RVTV..DHN..YYAI.CQN..L........LSRYamwrg........................ssgglL.H.DP.........PP......HIAKDg..qLEALLDECANP............................................................
A0A093FVS2_DRYPU/1-118                 ....................................................q------.......--.---....---..----...-.-....----------.........-....-....-....-...-.-.--.---------.........................................................------.-.-..-.---...-..--....-..-I.CLSLVK.LLFY...L.......A.....HS..........PL...............GS...IVLLDF.....Q.....P.RQFV..MV.....D-.......G..N...L..KV..TDMDDAS.TEEL..-...---.--..-.-SCKE........D.............................NDCTL....dF......PTK....SfplK...C......S..-...A.VG..K..CE..GINE..KKN..LFNA.YRY..F........FTYL..................................L.P.HS........aPP......ALRPF....LSDILN-----at..........................................................
A0A4W4FBW0_ELEEL/227-410               ..............................................lasfkiv------.......-K.EMT....LME..RLQH...P.N....--ILKLYGYC.........N....Q....D....Sn.dI.K.DT.VTAITELGS.........................................................PLEMIQ.L.L..Q.TPW...E..ER....F..RI.CLSLGR.LLHY...L.......A.....HS..........PL...............GS...LTLLDF.....R.....P.RQFV..LV.....GG.......-..E...L..KV..TDLDDAS.VEET..-...--P.C-..-.-SPAT........P.............................ANCLL....eF......PAR....NftlP...C......S..-...-.RG..R..CQ..GINE..KRN..LYNA.YRF..F........FTYL..................................L.P.HS........aPL......ALRPL....LDRIV------nstge.......................................................
A0A3Q0KQK3_SCHMA/273-352               ....................................................l-FNLAI.......DP.QSV....IIQ..SFPR...K.E...nWPFPTYLGSC.........G....R....W....S...V.E.EY.HG-VP----.........................................................---LSY.F.C..L.APL...W..IR....L..QI.LLNILS.LPEK...L.......E.....HQ..........SS...............DE...L-----.....-.....-.----..--.....--.......-..-...-..--..-------.----..-...---.--..-.-----........-.............................-----.....-......---....-...-...-......-..-...-.--..-..--..----..---..----.---..-........----..................................-.-.--.........--......-----....-----------nhd.........................................................
A0A091TS41_PHALP/46-227                .....................................................LYTLSV.......NS.HPI....LLQ..IFPD...V.E...gWPFPRYLGSC.........G....R....L....V...V.S.AS.TQ-------.........................................................--PLRD.F.Y..G.AAP...E..VA....A..DL.ALQLLA.VLRS...M.......G.....TN..........DL...............NY..fFYFTHV.....D.....A.GTFG..VF.....SN.......G..H...L..FI..RDASTLG.IIDK..E...EGS.QL..I.DGQQE........Y.............................KD--I.....F......SCL....T..vD...C......Q..S...A.FV..S..CN..SIRE..KHS..LVMV.CQE..L........LPKL..................................L.K.GK........fLQ......PVQEK....IDSFLQHCAD-g...........................................................
E7FCF0_DANRE/234-436                   .....................................................AWALLQ.......LN.EFL....LSV..VLQE...R.E....-HTPRLLGFC.........G....D....L....Y...V.M.EK.VPYVPLYGVslpwmve...........................................lwipaslRRSIDQ.W.A..T.PSW...P..RK....A..KI.AIGLFE.LVED...V.......F.....HG..........TF...............GS...FLMCDV.....S.....A.AGFG..YT.....ER.......H..D...I..KV..VDARQIV.PEVG..F...QEV.MR..E.RRCEE........D.............................TDCLY....gR......DCF....T...S...C......D..L...T.KH..R..CT..TEVT..QPN..LAKV.CST..L........KDYI..................................L.Y.GA.........PS......DIKDE....LDKQLYACIA-l...........................................................
A0A452FDA5_CAPHI/134-336               .....................................................AWALLQ.......LN.EFL....LMV..ILQD...K.E....-HTPKLMGFC.........G....D....L....Y...V.M.ES.VEYTSLYGIslpwvie...........................................lfipsgfRRSMDQ.L.F..T.PSW...P..RK....A..KI.AIGLLE.FVED...V.......F.....HG..........PY...............GN...FLMCDT.....S.....A.KNLG..YN.....DK.......Y..D...L..KM..VDMRKIV.PETN..L...KEL.IK..D.RHCES........D.............................LDCVY....gT......DCR....T...S...C......D..Q...S.TM..K..CT..SEVI..QPN..LAKA.CQL..L........KDYL..................................L.R.GA.........PS......EIREE....LEKQLYSCIA-l...........................................................
W5NC17_LEPOC/178-357                   ..............................................lvsykli------.......-K.EIM....LLQ..RLQH...P.N....--IIKLQGHC........qG....R....D....WgsgV.T.AA.LELGSP---.........................................................-LQMIQ.L.L..Q.SPW...E..ER....F..RI.CLSLVR.LLHY...L.......S.....IS..........PL...............GS...VALLDF.....Q.....P.RQFV..VV.....SG.......-..E...L..KL..TDLDDAS.TEER..-...---.--..-.-SCRT........D.............................SDCTL....tF......PHRn..fT...F...P......C..A...A.GG..I..CE..GLNE..KTN..LYNA.YRY..F........FTYL..................................L.P.HR........aPP......TLQH-....-----------lidnimnstg..................................................
F6R5C3_XENTR/476-678                   .....................................................IWALLH.......LN.EIL....LML..SLRE...K.E....-HTSQLLGHC.........G....D....L....Y...V.T.EK.IPHDSLYGSqipgflq...........................................tllpspvHRLVHQ.W.C..A.PAW...P..RR....A..KI.AIGLLE.FVEE...I.......F.....HG..........TY...............GS...FFICDS.....S.....F.KNIG..YN.....EK.......Y..D...F..KV..VDLRKVA.TEMT..I...RGF.LK..G.RHCEQ........N.............................SDCTF....gS......DCT....A...A...C......D..K...L.MK..Q..CR..NDVI..QPN..LAKA.CQL..L........QDYL..................................L.Y.GS.........PS......DLREE....LQKQLRTCMT-l...........................................................
A0A1U7S3Q4_ALLSI/197-399               .....................................................IWALLQ.......LN.EFL....LML..SLHE...K.E....-HTSKLLGHC.........G....D....L....Y...I.T.EK.IPHNSLYGMdvprflq...........................................pllpsaiHRLVHQ.W.F..A.PAW...P..RR....A..KI.AIGLLE.FVEE...I.......F.....HG..........TY...............GN...FYICET.....S.....F.KNVG..YN.....DK.......Y..D...F..KM..VNLRKVA.TEMT..I...RGF.LK..G.RHCEQ........N.............................VDCTY....gK......DCT....A...T...C......D..K...L.MK..Q..CK..SEVV..QPN..LAKV.CGL..L........QDYL..................................L.Y.GA.........PS......DLREE....LQKQLRTCMT-l...........................................................
A0A3Q2ZLW5_KRYMA/152-354               ....................................................t-WALLQ.......LN.EFL....LAL..VLQD...R.E....-HTPKLLGFC.........G....D....L....Y...M.M.EK.VPYTPLYGIslpwiie...........................................mwipaglRRSMDQ.W.F..T.PSW...P..HK....A..KI.SIGLLE.LVED...I.......F.....HG..........TF...............GS...FFMCDV.....S.....T.TIFG..YN.....DR.......H..D...F..KV..MDARYII.PEAT..F...QER.IR..Q.QRCDV........D.............................EDCLY....gT......DCL....T...S...C......D..L...T.KH..K..CT..PEVT..RPN..LAKA.CDR..L........KDYI..................................L.R.GA.........PS......DVSEE....LEKQLYACIA-l...........................................................
A0A3Q0HJA7_ALLSI/19-193                .........................................ttksdvnqqews------.......--.---....---..----...-.-....QTIPELYGQC.........Y....D....N....S...A.H.PD.IRVTAMLELg.......................................................sPLEMIQ.L.L..Q.TTW...E..ER....F..KV.CLSLVK.LLFY...L.......A.....HS..........PL...............GS...IVLLDF.....Q.....P.RQFV..MV.....D-.......G..N...L..KV..TDLDDAS.TEEL..-...---.--..-.-SCKD........D.............................NDCML....dF......PTK....SfllK...C......S..-...A.AG..K..CE..GINE..KKN..LFNA.YRY..F........FTYL..................................L.P.YT........aPP......GLQPF....LSDILN-----at..........................................................
D2I209_AILME/211-392                   .....................................................LYTLAV.......SA.HPI....LLQ..IFPG...A.E...gWPLPKYLGSC.........G....R....F....A...V.S.TS.TS-------.........................................................--PLRD.F.Y..G.AGP...D..QA....A..DL.AYQLLG.VLES...L.......R.....TN..........DL...............NY..fFYFTHV.....D.....A.DTFG..IL.....NN.......G..Q...L..FI..RDASALG.VIDR..Q...EGS.PA..A.AGAGD........S.............................KD--V.....F......SCL...lS...G...C......Q..A...E.LP..S..CY..TIPE..KQS..LVLV.CRQ..L........LPRL..................................L.Q.GK........fPS......PVQEE....IDNALAQCGE-d...........................................................
A0A671FYZ0_RHIFE/187-381               .....................................................LWSLLQ.......QE.EFV....LLS..LLQD...L.S....RHAPPVLGSC.........G....H....F....Y...A.V.EY.LAAGSPHHT........................................................aLFPLGG.A.S..R.GLA...R..AI....S..DM.ALSFLD.LVSH...F.......D.....ND..........FS...............HR...LHLCDV.....K.....P.ENFA..IR.....RD.......F..T...V..VA..IDVDMAF.FEPK..M...REI.L-..E.QNCTG........D.............................EDCNF.....F......DCF....S...K...C......D..L...R.VN..K..CG..AERV..NSN..LQVI.CDK..I........FRHW..................................F.S.STlgs...saiSL......ELRLQ....LQETVQDCADP............................................................
A0A0K0J806_BRUMA/224-409               .....................................................LWALLS.......QD.EYI....TFR..VLPL...T.R....-VTPKIIGTC.........G....H....F....Y...Q.V.ET.LVPFH---M.........................................................KGY---.-.-..-.-YM...N..LK....A..KI.LLHLMG.TLKL...F.......D.....EF..........LN...............EP...LEWCDI.....K.....F.DNLG..LA.....AD.......YpkR...F..MV..MDADMLY.TKSR..L...KAI.LT..S.RICKQ........D.............................EDCHY.....F......DCY....A...K...C......N..N...E.TG..F..CT..-DRT..NSN..LEVF.CDK..L........IYQL..................................-.-.--.........--......-----....-----------ygkfwtksnrylaacrdtsvtfeqriadl...............................
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