#=GF ID   PRD_Mga
#=GF AC   PF08270.16
#=GF DE   M protein trans-acting positive regulator (MGA) PRD domain
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_5126 (release 7.7)
#=GF GA   23.00 23.00;
#=GF TC   23.70 23.20;
#=GF NC   22.80 22.80;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 8 -Z 90746521 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0166
#=GF RN   [1]
#=GF RM   11952907
#=GF RT   Two DNA-binding domains of Mga are required for virulence gene
#=GF RT   activation in the group A streptococcus. 
#=GF RA   McIver KS, Myles RL; 
#=GF RL   Mol Microbiol 2002;43:1591-1601.
#=GF DR   INTERPRO; IPR013236;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Mga is a DNA-binding protein that activates the expression of
#=GF CC   several important virulence genes in group A streptococcus in
#=GF CC   response to changing environmental conditions [1]. This
#=GF CC   corresponds to the PRD like region.
#=GF SQ   56
#=GS E8K314_9STRE/174-392      AC E8K314.1
#=GS Q99XU9_STRP1/179-397      AC Q99XU9.1
#=GS H3NIL0_9LACT/173-388      AC H3NIL0.1
#=GS A0A4R9BZX7_9FIRM/171-391  AC A0A4R9BZX7.1
#=GS A0A917N4K7_9ENTE/173-388  AC A0A917N4K7.1
#=GS K1LPL9_9LACT/172-390      AC K1LPL9.1
#=GS S0KQC2_9ENTE/175-392      AC S0KQC2.1
#=GS C8NG86_9LACT/173-392      AC C8NG86.1
#=GS W1Q4A6_ABIDE/132-350      AC W1Q4A6.1
#=GS B9DT24_STRU0/177-394      AC B9DT24.1
#=GS A0A0U3MC74_9LACT/177-384  AC A0A0U3MC74.1
#=GS Q8DYW7_STRA5/169-385      AC Q8DYW7.1
#=GS H3NDN7_9LACT/175-400      AC H3NDN7.1
#=GS A3CQR4_STRSV/173-392      AC A3CQR4.1
#=GS G5JZP2_9STRE/178-374      AC G5JZP2.1
#=GS A0A1M4VE17_9LACT/172-389  AC A0A1M4VE17.1
#=GS F4BS53_CARS1/173-392      AC F4BS53.1
#=GS A0A0H2ZN44_STRP2/173-392  AC A0A0H2ZN44.1
#=GS H3NE90_9LACT/179-400      AC H3NE90.1
#=GS A0A4R9C3B8_9FIRM/195-396  AC A0A4R9C3B8.1
#=GS A0A347WJL7_9LACT/172-390  AC A0A347WJL7.1
#=GS Q034F8_LACP3/175-389      AC Q034F8.1
#=GS A0A0H2ZQ44_STRP2/173-391  AC A0A0H2ZQ44.1
#=GS A0A0P6SF93_9STRE/177-394  AC A0A0P6SF93.1
#=GS Q8DP24_STRR6/181-399      AC Q8DP24.1
#=GS F3AEN4_9FIRM/2-199        AC F3AEN4.1
#=GS V8BCG9_STRPA/173-390      AC V8BCG9.1
#=GS A0A347WJT6_9LACT/175-392  AC A0A347WJT6.1
#=GS A0A429ZHR0_9ENTE/177-387  AC A0A429ZHR0.1
#=GS A0A347WNV7_9LACT/157-348  AC A0A347WNV7.1
#=GS K8E1E3_CARML/172-386      AC K8E1E3.1
#=GS A0A940PDR4_9ENTE/178-385  AC A0A940PDR4.1
#=GS Q9A1S4_STRP1/171-380      AC Q9A1S4.1
#=GS D0BJK3_9LACT/173-391      AC D0BJK3.1
#=GS A0A662Z1T8_9STAP/175-391  AC A0A662Z1T8.1
#=GS Y1800_STRPN/173-392       AC Q97P44.1
#=GS A0A1H9AUM2_9LACT/173-393  AC A0A1H9AUM2.1
#=GS A0A4R9BZY2_9FIRM/182-392  AC A0A4R9BZY2.1
#=GS H3NI02_9LACT/175-390      AC H3NI02.1
#=GS W7CLY3_9LIST/180-385      AC W7CLY3.1
#=GS F9HJB6_9STRE/173-392      AC F9HJB6.1
#=GS A0A1F2EMR7_9LACT/175-390  AC A0A1F2EMR7.1
#=GS A0A0X8FM36_9LACT/173-363  AC A0A0X8FM36.1
#=GS Q8DNN5_STRR6/192-411      AC Q8DNN5.1
#=GS A0A347WJV4_9LACT/173-392  AC A0A347WJV4.1
#=GS F3AN62_9FIRM/2-199        AC F3AN62.1
#=GS A0A1D2LU82_BROTH/180-381  AC A0A1D2LU82.1
#=GS A0A1X7KM69_9BACL/173-359  AC A0A1X7KM69.1
#=GS A0A2N6SQ50_9LACT/19-238   AC A0A2N6SQ50.1
#=GS A0A839A7F6_9LACT/173-391  AC A0A839A7F6.1
#=GS F4BSA8_CARS1/173-390      AC F4BSA8.1
#=GS A0A0H2UNQ4_STRPN/186-385  AC A0A0H2UNQ4.1
#=GS A8AZ88_STRGC/173-392      AC A8AZ88.1
#=GS A0A6G8AMQ0_9ENTE/170-391  AC A0A6G8AMQ0.1
#=GS A0A6I2GF92_9LACT/173-390  AC A0A6I2GF92.1
#=GS A0A0X8FBX0_9LACT/173-394  AC A0A0X8FBX0.1
E8K314_9STRE/174-392                 ............................k-EADIDSFV...SFFINLAKFPAKYQNLY.QIRTQ...ATVDLHRMKRGYFV..R...FPKQ..TT-.S.WLS.PIYDQ.L...SDFQ.YQLQDLAQGLNVEVTPENLNQIFSPFAEPG..L.FFTVE.D.FLEARQ.SY.EQ..V.D......RS.YHTAR...DILDNL..T..RRFGVQFSNTDTLIWNLHNTALLE..R.REINS..ESIISQNKDYTLGKIKKFFPKFYEATV...FEM.MRYKNIM.G..QK..E..KTPALSHLIYTLFTHAEGL.....................................................
Q99XU9_STRP1/179-397                 ........................lknce------RLL...SLMIKEVDVRVNFTLFQ.HLKIL...SSVNLIRYYKGHSA..V...YDNK..KTS.Q.RFS.QLIQS.S...LEFQ.DLSRLFHLKFGLYLDETTIAEMFSNHVNDQ..L.EIG--.Y.AFDSIK.QD.SP..T.-......GC.RKVTNw.vHLLDEL..E..IRLNLSVTNKYEVAVILHNTTVLK..E.EDITA..NYLFFDYKKSYLNFYKQEHPHLYKAFV...AGV.EKLMRSE.K..EP..I..STELTNQLIYAFFITW---ensf.................................................
H3NIL0_9LACT/173-388                 .........................dvhq----VHQVM...RLGAKAFDFHLSFDKVH.KWMTR...TAINLVRNHYGYYL..D...LEED..LL-.N.YVH.QQIQQ.S...PDWP.AFQAAYQAATHLTCTPRLLIECFYPHIHEA..F.CMD--.-.-QPKSK.QE.EA..N.Q......NT.YQAIQ...DFLAGF..T..DHFKIELEDTHDLVQDLYETIQLN..Q.QNLLR..P-LFVSRRDQFIQGFRMDFPLIYDYLT...QEI.TSIANHL.NlkPC..E..EDSLIHQLVYTAIIKLS--pl...................................................
A0A4R9BZX7_9FIRM/171-391             ...............keierssfhnmiie---------...--FYNINNAKFVYSFLE.IMSLI...CAVNFTRIKNKGFImnN...IDKN..NI-.-.-NL.NSLQN.Y...INSN.PFKE-FFNKFNIVLNEDNLIELFYNYLNKD..F.I-F--.S.FKEMIE.KS.KY..V.N.....lIS.SSLLKi.lSETDRI..R..KKFKLNLENLDELIIRIHNGAILY..N.TNTNI..NYIAYNRNDFYVTQIKQVFPKFTKDVE...LFI.QDLLIEI.K..GV..A..KPFEINHLTYILISTWN--dl...................................................
A0A917N4K7_9ENTE/173-388             .......................qvalvd------SLI...KTFAQVFDFPLNFPDMK.LLRVI...GLVNITRISHQHVL..S...IEHL..TT-.-.QYD.DLISM.L...VEAP.DFQQRFSLLFGFEGTVSVIKDVFSVFLAPS..F.VLDSY.Q.QTLNAI.QH.SL..S.E......NE.FLANF..tLFLDTL..H..KRIPIVMSNKTQVIQEV----FNL..Q.HLFFG.nNYILFDKHSQFIKSIEKDFPNFMTILK...QEL.HNLKFYP.S..FE..W..TDVSFNTVLYTMIIHWKNL.....................................................
K1LPL9_9LACT/172-390                 .........................dida----LKEFL...ISSYSIAGAQLNYPTLR.FLLFS...LSVNIVRLRQGHRI..F...VETN..AF-.D.IVY.QEFLK.M...PDQV.DRMQELAQQLGFELTLNNIKQLFIAYAKEA..F.ELP-S.I.KETINE.TAiES..V.R......QS.TEYLA...QIIHQL..S..DKYHVPIEDVAELAGYLHNTAHLF..K.WETET..FNILYPYLPNFIDRAYYYIGDFVTEAQ...QSL.HDYIEAM.E..LD..S..SEMMHNLLVYDLITHWPNL.....................................................
S0KQC2_9ENTE/175-392                 ...........................sd--NALSTLV...TALLKENKLPQNYRQHE.QLYFS...GAVSIWRQNNGHLLpqE...IEKS..GFL.KaESS.STTNA.V...VQLK.ETLMSINWHFNFLETFWTVCHDYVL-----..-.-LSFA.H.FQQAQK.RN.PR..I.K......RL.AQRTN...HYLDALlsS..TKQNIASLEKEELIWHFCNENYIH..L.RNCDF..IAILSNCRREFVLNYEKKFPNVITGLK...KFI.NNYHNKY.Q..IH..I..TSDQVYQQLYLIITL----lpqi.................................................
C8NG86_9LACT/173-392                 ...........................sp--DPLSQLL...ELVYKATSFPMNLSTHR.MLKLL...LVTNLYRIKFGHFL..E...VEKD..SFN.N.QLL.EFLMQ.E...DEME.DIVKKFETEYNISLTKEVIGQLFVSYFQKM..F.FIDEK.V.FLKYTK.TD.IY..V.K......KS.YHLLG...DLVDQV..S..KEYNIKVDNKDNLIWHLHNTAHLH..R.QELST..EFILFDQKGNTIKNFQNIFPRFVSDLK...EGI.LHYLQTL.D..ID..S..SSMKVNHLAYTFITHSKHL.....................................................
W1Q4A6_ABIDE/132-350                 ...........................ke--AHVDKFV...ATFIKILDRPLDFSLYY.LIKRA...TIINIKR--HHFKR..D...LPLH..KTNvS.TLF.AQALE.Q...KADQ.EFVRSLADYVGEPLGDIVLSNLLYPFLRDD..F.FYTYE.D.MLKASR.LQ.AA..I.H......TS.LTQAQ...LMIEDI..R..QHFNLEINNPEVLTILFHNASSVE..C.YEVFA..KSEIFRRRATWMSHLYEDFPDFYNYIE...KSV.IQYRQAN.K..LH..T..GTEIVRYLIYTIFSTWS--el...................................................
B9DT24_STRU0/177-394                 ............................n-EIALTSLV...DMTASKFSHRVTHSLFA.YLKIM...SAVNLIRFSKGYRV..N..eVYPR..SC-.-.SLY.EKLKE.D...PTFL.HLSELFWRDFGKPLDQVALSEMFSTYFRQD..L.ILN-A.E.LDRQNT.DK.EV..E.G......VT.YEDML...ETLEGI..E..NRFGMPIANKSEISLLIYNALILK..E.HDIYE..NFLVYDYREPYIAYFNDSYPKLLEAFQ...EAL.LAPFKAK.G..VE..L..AKERQNHLLYILLVNWDNL.....................................................
A0A0U3MC74_9LACT/177-384             ........................dtaqt-------YI...ELLPKNVNTPNFSEIAQgKVALW...LVICLERIEQGYFI..D...HEYE..IF-.-.-PF.KVSKK.E...PLFD.LLQKDLSFTIPLE-DQNFMTYLY---QNKD..G.PLD--.-.-KTYLA.EN.SR..V.V......GL.FQEIL...AFIEAL..K..KQTGYTLENQSCFITNL-IRHYFY..R.SLFKG.pGHILIDRVERNGKALERNFDKFTKAVR...ETL.AASPSNN.W..VE..K..MRENENDLIFTLIT-----fwtgl................................................
Q8DYW7_STRA5/169-385                 .............................SEVMIRDFIeysNFKGCDYDLKDLSEEYY.YFYIL...VNLVWKR--KEYKV..E...IPQT..ESF.N.QLK.KSILY.M...ELSK.AAQKSIAIHLGIELNEGLLDYLYLVFCISD..G.PLF-S.N.RDDINI.NE.EF..I.F......AS.YKISKs.kAFKNFC..G..RLLGREFIDSQHFKDIN---AYFL..R.HFICY.cYYFIPDFYFLNTSRLSYSK-DLYHLLD...KGL.ADIFNLK.G..G-..-..NLTFSKHETVLLTMQLSNL.....................................................
H3NDN7_9LACT/175-400                 ............................n-EAELDDFL...WYFVKALDVSIQFISFT.SFKIY...TYVNIQRYKQGNIV..DpqtMNTE..NYL.N.QLF.DNLNN.D..pDKIQ.ELKDMISHVLNIPFSTEMIGQIFHNYMQSE..Y.CLNYDdL.ISNIQS.NE.KY..S.S......--.-LLLNl.dSMLYKL..K..KEFEIELPNKFDVILELHNATHSH..N.IDLGS..NYLLIRHNHYFCNHMEKIIPFFYERAK...ELI.RLFINQY.H..SS..KkmDTTLHSYLMYTLIVNWQNL.....................................................
A3CQR4_STRSV/173-392                 ...........................sv--EPLCKLL...ALVYKETAFPVNFATQR.MLKLL...LVTNLYRIKFGHFL..E...VEKD..SFN.N.QLL.ESFMQ.A...EGIE.DIVASFDSEYHISLNKEVIGQLFVSYFQKM..F.FIDEN.L.FMSCAK.TD.SY..V.K......NS.YQLLS...DLIDQI..E..SKYNLKIDNNDNLIWHLHNTAHLH..R.QELST..EFILFDQKGNTIKNFQNIFPQFVSDIK...KGI.EYYLETL.D..IH..S..TPMKVNHLSYTFITHSKHL.....................................................
G5JZP2_9STRE/178-374                 .......................nkknhe------RLI...SLLVEKTSLNINFALFQ.HLKIV...SGVNLIRFQKGYRI..N...EYNN..NQG.K.LLL.NALEN.S...KEMK.DLSSLFRMKFNYYITEDVLTELFSNYLDKR..L.ELGIS.T.-KTVAF.SR.EV..T.P......SP.YILSSw.iAVLDSF..E..QKLNLSISNKYNLAVHLHATVILG..Q.EDIGV..NFLVYDYKQNYLTLLSSQY--------...---.-------.-..--..-..-------------------etiyscflnlvedlydk....................................
A0A1M4VE17_9LACT/172-389             ..........................den---GLDLFL...NFFIKFTHMDADFAYYN.IFKTV...SAVNLIRYKQGHFV..N...ISNI..HV-.-.NFD.EIIPD.L...TVYQ.ETFSYFEETNQVKVDNMLIQQIFTPYISEE..F.SLNYE.R.LIEKTK.TQ.QK..L.S......TE.VAFLD...DMLEDL..S..KTHQLSLNNKETVLLNIMNAAYLE..Y.KEPRS..GYILHNHNLEFASKIESEFPFFYKNLY...QAT.KNYRQLI.G..KP..L..IDDGIFFMMYTI-------fifwedl..............................................
F4BS53_CARS1/173-392                 ........................nqnff-----EQLL...IFIAKTNNIPVNFADFK.RLKLW...TAVPYLRVKQGHQV..S...VMSS..NY-.-.--S.KMIPD.F...SNFQ.PLTGLIEKKLAITLDKNFIEQVFSIFINND..FkFSYES.L.IEDTKI.NP.AV..KeR......VS.YH--T...TLLHNL..S..NQIGIPIPNQQHLLKEMFNISHFVfkS.KEGQYplPYILFNSKKYFVQSMEELFPDFITLAF...SNL.KKYEKKT.N..EH..Y..SETARYEIIYTLLIHWDHL.....................................................
A0A0H2ZN44_STRP2/173-392             .............................SSEPLSQLL...ELVYKETSFPMNLSTHR.MLKLL...LVTNLYRIKFGHFM..E...VDKD..SFN.D.QSL.DFLMQ.A...EGIE.GVAQSFESEYNISLDEEVVCQLFVSYFQKM..F.FIDES.L.FMKCVK.KD.SY..V.E......KS.YHLLS...DFIDQI..S..VKYQIEIENKDNLIWHLHNTAHLY..R.QELFT..EFILFDQKGNTIRNFQNIFPKFVSDVK...KEL.SHYLETL.E..VC..S..SSMMVNHLSYTFITHTKHL.....................................................
H3NE90_9LACT/179-400                 .................lekslldlislm---------...-------DITVEFMTFA.SFKFL...TYVGLRRYKQGNLV..NsdtLNTA..FYL.D.HLY.QSLNYdS...DKIK.QFKQHTEKIFGIPYSDELIGQIFYVYVQNN..Y.AIN--.-.YDHLIQ.MN.QH..D.L......KS.TQLQLdigGMLYRL..S..HEFKIDLPNKFDLLLEIHNSIHLF..N.IDLGS..NYLYVRRNHYACKHLQQLIPEFYERAEgllREL.VSSLEIK.H..L-..D..DPNYMEYLMYILLINWH--dl...................................................
A0A4R9C3B8_9FIRM/195-396             ..................vkkfpyidnei---------...-----------------.-MTIL...YPIHIERLKSGHCV..-...LPYL..--I.K.ENF.NTIKV.Q...EAYNcSELKNLFEEFELEFTKENIIDIFYYYLHKD..I.AFSFL.D.LIKKTK.SN.TL..I.N......FSiYQALE...S-TYKL..S..DKFNLKLNNPYELITYIHNANVFL..Y.DNFNS..NYIVFDKHNIYISKLQIVFPEFMKELS...KTI.KKYLLII.K..GE..V..KKCHIEYLIYTVISTWDNL.....................................................
A0A347WJL7_9LACT/172-390             ...........................de--RVLETFI...QYFTRELNIGMNFSYYY.FVKIL...TAISLIRTIQGFFI..E...TDNS..HI-.E.PVY.NVIKD.Q...HTFK.EMKKYIREHYDRELDIDFIGQMFISFLSPN..Y.FFTID.S.FYLETR.LN.DQ..I.N......SS.ITYLD...WMISRL..M..RDFDLELDNKQELIYELHNTNVLN..K.ADLNV..TPILYDQKGGFVREFSAKYPEFYEAAF...KAM.QGYRNHM.L..EK..P..DYYMERHLTYTLIVQWR--yl...................................................
Q034F8_LACP3/175-389                 ..........videliseffaqfpslqsp---------...--------ERQVFSYLN.KLRTM...LFISFKRLKKGRRL..-...-ASH..DQI.D.EQY.SLLLS.E...K---.-LSKKIAVCYHIDCTKDVLHQLFFLFFNRR..Y.AWSAN.D.LQKKAE.HD.EA..I.A......KV.RRTLL...AFFAKI..E..KSEQLVLINKDELLLLLYNATSYT..-.--WTS..AKILHNPSEDFFVNLNHYHEGFARRIK...KEL.VACLN--.-..--..-..-------------------reqldiylddsvinqllfmlvtawkgl..........................
A0A0H2ZQ44_STRP2/173-391             .............................PEEDLTEFA...DFFYKITNYPMRFSIYR.MYKLM...IAISIHRVKNGHFI..D...LPNH..FY-.K.EYY.PLLKS.I...PNFQ.ETLAYFSKHFGLEMTPDTIAQIFISFLQND..I.FLDPQ.E.FFNSLE.DN.SQ..A.R......YS.YQLLS...QILEGL..S..KQYKITFTNHDELIWHLHNTAFFE..R.QEIFS..TPILFEQKALTIKKFEVYFPDFMGSAR...QEL.AQYRQAI.G..QH..D..HPEQLEHLMYTILTHAENL.....................................................
A0A0P6SF93_9STRE/177-394             .......................ennhgr-------LI...HLMASLTEIDLDFSIFR.YLKIL...SAVNLIRYLKGFAI..G...EEKK..LS-.G.IFL.SLLSD.S...QEMQ.DLSHLFTLKFSLPLDELALSEMFSNYLDEG..L.VLGRS.L.QVTNSQ.TE.PL..G.P......KS.LNSWT...DLLSKV..E..HDTGLVLSNKYEVARRLHATVILA..A.EDIND..SYLIYDYKREYLAFFKKHYTHVYHKLV...DYI.RELFACG.Q..ED..L..ADTIQNNLLYTLLTTWENL.....................................................
Q8DP24_STRR6/181-399                 .............................PEEDLTEFA...DFFYKITNYPMRFSIYR.MYKLM...IAISIHRVKNGHFI..D...LPNH..FY-.K.EYY.PLLKS.I...PNFQ.ETLAYFSKHFGLEMTPDTIAQIFISFLQND..I.FLDPQ.E.FFNSLE.DN.SQ..A.R......YS.YQLLS...QILEGL..S..KQYKITFTNHDELIWHLHNTAFFE..R.QEIFS..TPILFEQKALTIKKFEVYFPDFMGSAR...QEL.AQYRQAI.G..QH..D..HPEQLEHLMYTILTHAENL.....................................................
F3AEN4_9FIRM/2-199                   ........................nflec---------...-----------TSAEYG.YFEYL...LILAWKR--KKYPL..T...FEKS..EEL.E.SLK.QLFVF.P...ELKK.YLQENLENKLNISFSDRDYDYIFLVYCCTNscV.FADKW.K.REDIEL.VH.KI..I.F......AN.GKV-K...HLIKKF..E..NKFCLDVTQSHAFKSSI---IYFY..K.KCFFN.lHCIIPDKHFYLDSKKDSSK-LM---VR...QCV.SE-----.-..--..-..-------------------midtwkkenhipypvdaghlqylslqif.........................
V8BCG9_STRPA/173-390                 ............................k-EEAVTDLI...TFFFKLYGYPLTFSVLR.SYKVL...LTVYLSRIKQGYFI..D...MPTN..-Y-.D.VYK.DQYQG.V...TNVE.EMLRYFSLQLGVELNEKVLEQFFIIFIQEN..F.YFSPE.S.LIEAAE.TD.PY..A.K......ES.TTLIR...DMFKDL..C..YTYDLDIENLDEMLMHVHNTSHLD..R.KELFS..EFLLFDTKTNTNEDFMSIFPAFYDDLK...EHI.ITYMKTM.K..HD..L..NEEIIKHMIYTVYTHWERL.....................................................
A0A347WJT6_9LACT/175-392             ...........................de--AFITDLL...VFLTDLLNVPMTFASMQ.MVKMN...ISVAMTRTLQGFRI..E...SNHS..KI-.Q.AMY.QIALD.M...HDFR.RFQAEFKKHYDIELNMDFLEQLFSEYTGEY..Y.YFNHD.D.FYMAQQ.AN.TY..V.N......QS.VTYLN...LMLTNI..S..SMHRLEIPNRKELIYHLHNTAHLD..Q.FDTYV..TPILFPRKRRFVEEVESMYPAFYQDIY...RGL.VGYRDFL.E..RP..V..DENMLNHLIYTLCI-----fwet.................................................
A0A429ZHR0_9ENTE/177-387             ................fqnllltqleplg---------...--------LKLKFSEIE.LLTFM...FLTICTRVKFGMLL..S...FPND..DV-.-.KNH.PWIDL.F...LSDK.TFSLLFKKEFKRSWNAVIIEQIFYPFLKDT..F.FFSIT.E.LDLAAD.LS.KD..I.Q......QR.LDRIK...SLIHSL..S..TKIATPIPNKKELVLILYNYHLF-..-.-FIGN..NHVLFDKRKNYVLTLSEEYPQIVSLMK...QTL.LDFQFHD.H..FE..W..SEAALNEAIYLLTTNWEN-f....................................................
A0A347WNV7_9LACT/157-348             .................deqsltncltni---------...---ALALNIPLDYKKLR.YLKLA...TCVSWLRLRQGHKF..H...LGNRreRII.D.EAR.D-ILG.M...PRFH.SCLRTSSIMNALSFDEDLLSQTFAIFMNQA..H.LID--.-.-LNSYS.DD.VF..I.E......ES.RVFFQ...DKVEEL..I..ERFSLKLEDTEA------------..-.-----..---------------------------...---.-------.-..--..-..-------------------yyrqivsnirlipasleartlfvdritpfneciqafnpdfyqalsamtqeyld
K8E1E3_CARML/172-386                 ........................kelgl----INTIL...DFFLKYYQDDSGFSNKK.KLLFS...AMTALTRLKNGHVR..K...IGKI..SK-.-.ENE.EIIHE.I...LSHT.NLVQSFRQLMGIELTKNMLIQLFYVFFHDD..Y.ILS-T.N.IFPEKL.HN.PK..V.E......ED.FAIID...QFLESL..S..IKLGIELQNKELLVLKI----YNA..R.NFLFG.kNYILHNKKIGFSQHIEQEYPLFSKILK...KEIkAASFSTI.E..K-..E..NPSFFNEVLYELIIHWTNL.....................................................
A0A940PDR4_9ENTE/178-385             ........drllqkladalaidltfpdlk---------...-----------------.QVRLT...LATGLIRIKNGHT-..-...-QSH..EL-.-.ATD.SPILQ.L...LLKE.EAVQDLENACQLKLDSEALIDLFYFFLRED..Y.ALTAD.YlYQTLMP.HN.PA..I.K......QT.VATIE...NWLTTL..A..DRLAIPLENKEILTWEIYN---VQ..R.VFLID..NFILFNKKQAFRQQALAEYPQLIPLLK...REL.SLLTTEM.G..SR..W..NETAIDEVLYMILIHWPNL.....................................................
Q9A1S4_STRP1/171-380                 ..........dkntihsflshssthlkts---------...---------PWLSESFS.FYDIL...LALSWKR--HQFSV..T...IPQT..RIF.Q.QLK.KLFVY.D...SLKK.SSHDIIETYCQLNFSAGDLDYLYLIYITAN.nS.FASLQ.W.TPEHIR.QY.CQ..L.F......EE.NDTFR...LLLNPI..I..TLLPNLKEQKASLVKAL---MFFS..K.SFLFN.lQHFIPE---------------------...---.-------.-..--..-..-------------------tnlfvspyykgnqklytslkliveewmaklpgkrdlnhkhfhlfch.......
D0BJK3_9LACT/173-391                 ............................n-EEDLDEFA...KYFYTPTNYPMGFAIFH.MYKWM...VMIGIYRVKNKHFV..P...IPDN..FF-.D.EVF.PPFAQ.L...PDIE.EKLVYFSEKFQISMTPEVLAQIFISFIQDT..I.FLSPE.E.FYASLE.ED.EY..A.K......NS.CRLLD...EMLLKL..E..FKLNIHFNNRNDLIWYMHNTVHLE..R.QETFT..DPLLFNQKQRTMNNFQKHFSSAFEIVK...SEI.MNYLKLM.N..RT..H..TPEHIHHLIYTLFTHGED-m....................................................
A0A662Z1T8_9STAP/175-391             ............................n-EKELESFM...YSFIKELPLDIDFAFFR.NMKFI...IAINIIRIKKGFKS..K...L---..SSN.N.DID.PFILE.V...LDKN.HTHSKFSKLINLELNLETIKDIFYGFVDEL..I.SYSSN.E.LIESAT.RN.IT..I.S......QS.YFQML...NIIKQL..T..TKFDLTIPNQEIVITNLHNTVTLG..Q.IEVTS..NFVSEDRIKSFLQSAKDISPHFLNEAK...YLF.TEYLEDV.F..GI..K..DDVLLNTMLFNIYTHW---hgl..................................................
Y1800_STRPN/173-392                  .............................SSEPLSQLL...ELVYKETSFPMNLSTHR.MLKLL...LVTNLYRIKFGHFM..E...VDKD..SFN.D.QSL.DFLMQ.A...EGIE.GVAQSFESEYNISLDEEVVCQLFVSYFQKM..F.FIDES.L.FMKCVK.KD.SY..V.E......KS.YHLLS...DFIDQI..S..VKYQIEMENKDNLIWHLHNTAHLY..R.QELFT..EFILFDQKGNTIRNFQNIFPKFVSDIK...KEL.SHYLETL.E..VC..S..SSMMVNHLSYTFITHTKHL.....................................................
A0A1H9AUM2_9LACT/173-393             ...........................de--HFLEEFL...IFLSHHCQIKLTFADLR.ALKLS...TAVYLYRHFDQHIAnwH...IDQD..KS-.D.DYY.HSLMM.D...YRFR.NLQVEFEQRYQITFNQKTFEDLFGPYLHPL..Y.FLSFR.D.WQQERK.YS.PL..A.E......KS.YQFLS...HWLTDL..A..RQFEIPLENKDLIMLKLHNTLQTE..G.IETRA..IFLMSNRKQQFCQLIKDKDIEFYHKIH...QGI.LEYRQLF.H..KN..D..NIQIVYHMIYLVYITWTNL.....................................................
A0A4R9BZY2_9FIRM/182-392             ................iteyfkinninkf---------...--------------EYS.YLEIMswtCAVNLHRTKLNFPV..-...ISQM..ETN.K.INY.DIIKN.L...LKSN.-ILQNIFRTFYIPLTENNLINIFYNYVHVD..L.VHTFK.E.FTDKAD.YS.PN..I.A......IS.LH--R...GFSDTF..SikNKYNLQLNNIENLIISVHNSAVLY..N.SDIKS..NCVIYNRRKMYIDQIYKQFPELVTDIK...TYL.SNYLTSL.K..GS..I..KKNEVEHLTYVAVS-----twkgl................................................
H3NI02_9LACT/175-390                 .............qplmlefvqipfsyie---------...--------PSQSFASFR.NFLLE...TTVNLFRIQQGYNS..Q...LSTV..DQK.KiNAC.SIILS.D...THFH.TIKQDVEQFFAIRIDTTQIYQIFFNYLHES..F.ALS--.-.TMDLME.TP.DH..-.H......RS.FQLLR...QMIHSL..C..DEFNITTENSRDLIIYLHNLVHSE..N.FYIGN..QPLLINRNQSFSQMARFLQPAFYDRIK...SML.DHYLAEM.N..IQ..I..SENGKEFMIVCIYTQWKEL.....................................................
W7CLY3_9LIST/180-385                 ...lyemmcetvnetpamqdrlrlrywfm---------...-----------------.-----...--ASIIRINNGHHL..T...LESN..EV-.P.QEV.KQLYQ.N...EQLQ.---IAFTFLLDCEFTPTILMELLVIFADIN..Y.FSNTS.A.LKTHLK.QT.TT..D.N......LL.ARNIY...TFLTNL..S..ENTHIPLTNIDEVALQLYNKHYLL..-.--VGP..NYIIYNRKALFAKRIREVYPFFVASVQ...QEL.SKLSSAQ.D..FY..Y..KDYAVNEILYTLLIHWEN-f....................................................
F9HJB6_9STRE/173-392                 ...........................sp--EPLSQLL...ELVYKVTSFPMNLSTHR.MLKLL...LVTNLYRIKFGHFL..E...VEKD..SFN.N.QLL.ESFMQ.A...EEIE.DIVVSFDSEYHISLNKEVIGQLFVSYFQKM..F.FIDEN.L.FMSCAK.TD.NY..V.K......NS.YQLLS...DLIDQI..E..SKYNLKIDNKDNLIWHLHNTAHLH..R.QELST..EFILFDQKGNTIKNFQNIFPQFVSDIK...KGI.EHYLVTL.D..IN..N..NSMKVNHLSYTFITHSKHL.....................................................
A0A1F2EMR7_9LACT/175-390             ...................hfyqnlllym---------...---VSFTSYKLDTYSIR.SFSIS...VVVNEIRYNYGHKH..Q...LPLT..RLH.N.NLS.E-VSD.V...YGF-.-NLDELNKKFDLNLDQEYIEQILGLFIEQD..F.KYDYA.E.IKALRS.SD.AH..I.A......DI.LDSLE...EILDQL..I..HQFKVPLPNREALILELYNIVLIE..G.QARSK..PFILRDLFLEHNQMIRNFHPSFYDAVF...EGM.DKYCQLIfG..EH..Y..D------------------philyatiysvfnywedl...................................
A0A0X8FM36_9LACT/173-363             .........................nlqd----FDDLI...QDVALEINYNDYFIDYR.HLRFY...IAVNFFRYQAGHLT..E...----..DFT.D.KAE.QVIEQ.L...--SP.QVLDRLQQFFGQAMTPALAKQIFGRHVARD..F.YYTIA.E.MHEKLP.QN.NY..Y.S......QL.NAMFV...QQMDLV..C..QEFNMTLANRDLVILEMHNSYFLN..T.NPGNR..KYILHNHSAIIISDLRQHYPKVIDLL-...---.-------.-..--..-..-------------------itsyqnvpask..........................................
Q8DNN5_STRR6/192-411                 .............................SSEPLSQLL...ELVYKETSFPMNLSTHR.MLKLL...LVTNLYRIKFGHFM..E...VDKD..SFN.D.QSL.DFLMQ.A...EGIE.GVAQSFESEYNISLDEEVVCQLFVSYFQKM..F.FIDES.L.FMKCVK.KD.SY..V.E......KS.YHLLS...DFIDQI..S..VKYQIEIENKDNLIWHLHNTAHLY..R.QELFT..EFILFDQKGNTIRNFQNIFPKFVSDVK...KEL.SHYLETL.E..VC..S..SSMMVNHLSYTFITHTKHL.....................................................
A0A347WJV4_9LACT/173-392             ..........................dqq---VLDNFI...NFILDSFRIDINYEEFR.YVEYV...MSVTLLRMSLGFVL..E...VDTT..NPM.M.PIFeAFIQS.N...NQNV.EAFRVLVEALGIELTATNFSHMIAKFYETP..F.LNYGI.Q.NIVNME.RS.NL..L.E......ET.HRLIG...DIVDIL..T..EKYELQLNNRHHLMNNVNKLLHMS..S.SNLGS..NELFFRQQESFLRKIRAINPDFYKSIY...-E-.-------.-..--..-..-------------------lvdnklinayqndawssdylvaiillnweni......................
F3AN62_9FIRM/2-199                   ........................nflec---------...-----------TSAEYG.YFEYL...LILAWKR--KKYPL..T...FEKS..EEL.E.SLK.QLFVF.P...ELKK.YLQENLENKLNISFSDRDYDYIFLVYCCTNscV.FADKW.K.REDIEL.VH.KI..I.F......AN.GKV-K...HLIKKF..E..NKFCLDVTQSHAFKSSI---IYFY..K.KCFFN.lHCIIPDKHFYLDSKKDSSK-LM---VR...QCV.SE-----.-..--..-..-------------------midtwkkenhipypvdaghlqylslqif.........................
A0A1D2LU82_BROTH/180-381             .............fisatksnghtvnfpq---------...---------------IE.KLRIW...IMVIIIRLQNGNHT..D...VYTP..FS-.E.DVD.LSALE.N...PLFK.N---LFKLTFKVELTDEVIFRLFYPFINEN..F.AVNQE.T.LTSMVQ.KK.SE..V.A......EK.VTALR...TLLDNI..A..LKMNIPQPNQNEVLLNLYNISIFQ..Y.---GK..PYILYNRYQYFVDSIEKDYPEFIAVFK...EEL.SKS-NLG.E..L-..-..ETHTINSFAYTIFTNWQNL.....................................................
A0A1X7KM69_9BACL/173-359             .......................eqefar------QLL...AEFTAENEIDSSFFHQK.FLEIT...ILLCLIRMRNGHVR..P...VDES..FPT.D.IST.AFLDN.S...EMAS.A----CSQLFGISLNESELQQLFFMFLRPE..A.ARSEK.H.LMELVR.RK.QCnaH.H......RV.YQI-E...GFLDRL..S..ERLGIPIPNKRTLLLKLYNV----..-.-----..---------------------------...---.-------.-..--..-..-------------------qtlfeydkkydleadseffyehavktfpyfveavkevlke.............
A0A2N6SQ50_9LACT/19-238              .......................aeapfd------QIA...QVYLDHFETQINVGSYR.TLKLS...LLINLMRFKQGFFA..Q...MNDE..GA-.K.RFV.E-TMS.A...ERKK.KLKNIIEKDLGVPYSISFVTQFLGPIANTC..Y.FLSQK.D.ILNIFE.QL.PD..M.I......GP.QTYLF...HFFEKI..E..SNFDLEIPNRTEIIDALHVASYHS..F.LEIGN..KGIAYEPSFCFNQSVKTMYPKFYQMIQ...EGL.ATYVEMM.P..YKseN..NSHIIDDLTMVL-------fvtwkgl..............................................
A0A839A7F6_9LACT/173-391             ...........................de--AAIADLI...IIVTDAIHYPLDYIGIN.YMKFL...VAVNLVRLRQGHDV..E...IESE..KA-.A.YIY.KTLQS.T...PFKS.DQTKQTMKRLGVPLNQHTVNQLFHVFINSD..Y.IFPNS.K.IINFSK.DI.DK..R.I......ES.FNHFN...YIVETL..K..KEFDLTFDNPGPLILNLHNAAILN..H.LDIDS..GNILLDSKTKFIEDLSRRFPDFISRAS...QLF.QEYCMKM.G..SK..-..-------------------wdrflndrlihhlfiqwetl.................................
F4BSA8_CARS1/173-390                 ...........................he--NSLDKLL...IFFTDFVPLPIDFSHYN.DFKLV...TVVNLIRYQNNHYV..D...TDNF..EI-.-.NFD.EIIPD.L...SIYA.DIFQSFEDSLGVKFNNDLINQLFTPFVQEG..F.SLSYE.R.LIEKTR.EN.KT..M.A......AE.VSLLI...KLLDKL..S..TDNDIPLVNKERVILEMQNTTHLE..Y.QKPQS..GHILYNNNKYFSEAIRYKFPVFYNDLY...EGM.IAYRKLQ.D..K-..-..-------------------pitedgidfficslftywknl................................
A0A0H2UNQ4_STRPN/186-385             ....................shelleitp---------...-------------DEYV.HFSIL...VALTWKR--REFPL..E...FPES..KEF.E.KLK.NLFMY.P...ILME.HCQTYLEPHANMTFTQEELDYIFLVYCSAN..S.SFS-K.D.KWNQEK.KT.HT..I.QlilqhtRG.KHLLS...KFKNI-..-..--LGNDISNSLSFLTAL---TFLT..R.TFLFG.lQNLVPY---------------------...---.-------.-..--..-..-------------------ynyyehygiesdkplyhiskaivqewmteqkiegvidqhrlylfslylte...
A8AZ88_STRGC/173-392                 ...........................sv--EPLCKLL...ALVYKETAFPVNFATQR.MLKLL...LVTNLYRIKFGHFL..E...VEKN..SFN.N.QLL.ESFMQ.A...EGVE.DIIASFDSEYHISLNKEVIGQLFVSYFQKM..F.FIDEE.V.FLNYAK.TD.SY..V.K......KS.YQLLG...DLVDQV..S..REYNIQVDNKDNLIWHLHNTAHLH..R.QELST..EFILFDQKGNTIKNFQNIFPRFVSEVK...EGI.EHYLKAL.D..ME..R..NSMKVNHLSYTFITHSKHL.....................................................
A0A6G8AMQ0_9ENTE/170-391             ......sedkiktaktyfyyleentditl---------...-----------SYPDKK.LLTVV...FLTHLDRIAHGFR-..-...LTDR..PYS.N.DVE.PFIVS.FldnPDNP.IDKKAFYKTFNVTLSSDVIQEIFSAFLSND..F.ILTPA.D.FDKRLAlKE.EP..L.Y......SR.VGIIQ...TFLTNL..S..NRLKIDIPNYDKLVFELYN---IH..K.LFIGK..NYILFNRREYFAQYAKKEYPYFVSVLI...EEL.DNFK---.-..--..-..-------------------fdssfewdqdsfnevlytllinwqdi...........................
A0A6I2GF92_9LACT/173-390             ............................d-EKALTDLL...KITLNYIKLNVGHANFI.NFKFL...TAVSLSRLRNNYRI..D...LTLE..QT-.-.NLH.ELLIH.P...FDIT.PEFYATIKQLNIHITEDVLLQLFTLYIRQD..F.SLTYE.G.FLNKSQ.YN.HE..L.K......RS.IEALD...QLLEEL..S..ITYNIPLVNKEEIILTVQNTTYNE..G.YLPHT..AYILYNPNEELMTEIEKFSPEFIYDLT...VKV.QHYRQLV.S..KP..I..GHFTIEHLVYQICVRWKHL.....................................................
A0A0X8FBX0_9LACT/173-394             ....vnlqycelflstawkvtchqytnaw---------...---------------FQ.SGKIL...LAIGIIRTQKGHLI..Q...SKDI..PLF.K.GIY.QDLID.E...LEKN.DDLKNMEQSFNFKLNLTNAVQLFMPVLNQN..I.YVDLR.N.FQAEIS.ER.PL..I.Q......RS.VEYLN...QFLDTI..C..QEAHVHIEHRDRLILSLHNYAFLT..TvADIQK..DSLLIDRKADYIETMSHFYPDLYDLIV...KES.EHYFQSI.G..LK..P..-------------------lpygltnfiyalytgwekl..................................
#=GC seq_cons                        ............................t......phh....hhhp.hphshsasphp.hh+lh...hslslhRhppGahl..p...lspp..ph..p.phh.phlhp......php.phhpthppphslplspcslpplFhsahpps..a.hhs.p.p.hhpttp.ps.sh..l.p......po.hphlp...phlcpl..s..pcaslplsN+cpLlhpLaNssalp..p.pplts..paIlasp+tthhpphpphaPpFhptlp...ptl.tphhphh.t.........p..hhpphhYhhhhp.........................................................
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