#=GF ID PSY3
#=GF AC PF16836.12
#=GF DE Shu complex component Psy3, DNA-binding description
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE pdb_3vu9-A
#=GF GA 25.00 25.00;
#=GF TC 25.10 25.30;
#=GF NC 24.40 24.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 90746521 -E 1000 --cpu 8 HMM pfamseq
#=GF TP Domain
#=GF CL CL0023
#=GF RN [1]
#=GF RM 22465956
#=GF RT Structural analysis of Shu proteins reveals a DNA binding role
#=GF RT essential for resisting damage.
#=GF RA Tao Y, Li X, Liu Y, Ruan J, Qi S, Niu L, Teng M;
#=GF RL J Biol Chem. 2012;287:20231-20239.
#=GF RN [2]
#=GF RM 22749910
#=GF RT Structural and SAXS analysis of the budding yeast SHU-complex
#=GF RT proteins.
#=GF RA She Z, Gao ZQ, Liu Y, Wang WJ, Liu GF, Shtykova EV, Xu JH, Dong
#=GF RA YH;
#=GF RL FEBS Lett. 2012;586:2306-2312.
#=GF RN [3]
#=GF RM 23575680
#=GF RT A new protein complex promoting the assembly of Rad51 filaments.
#=GF RA Sasanuma H, Tawaramoto MS, Lao JP, Hosaka H, Sanda E, Suzuki M,
#=GF RA Yamashita E, Hunter N, Shinohara M, Nakagawa A, Shinohara A;
#=GF RL Nat Commun. 2013;4:1676.
#=GF DR INTERPRO; IPR031779;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC PSY3 is one of the components of the yeast Shu complex that
#=GF CC maintains genomic stability during replication. Psy3 complexes
#=GF CC first with Cms2, and their L2 loops confer the DNA-binding
#=GF CC activity to the Shu complex [1,2]. The Shu complex binds to
#=GF CC recombination sites and is required for Rad51 assembly and
#=GF CC function during meiosis. The heterodimer of Psy3-Csm2 stabilises
#=GF CC the Rad51-single-stranded DNA complex independently of
#=GF CC nucleotide cofactor because Psy3-Csm2 is a structural mimic of
#=GF CC the Rad51-dimer [3].
#=GF SQ 55
#=GS A0A1E5RI48_9ASCO/117-297 AC A0A1E5RI48.1
#=GS G8Y141_PICSO/1-220 AC G8Y141.1
#=GS C5DFB4_LACTC/1-169 AC C5DFB4.1
#=GS A0A512UIL2_9ASCO/126-244 AC A0A512UIL2.1
#=GS G8Y426_PICSO/1-220 AC G8Y426.1
#=GS A0A1G4JER0_9SACH/7-239 AC A0A1G4JER0.1
#=GS A0A9P0QTH2_9ASCO/1-204 AC A0A9P0QTH2.1
#=GS G0VKS3_NAUCA/20-233 AC G0VKS3.1
#=GS Q6FRY6_CANGA/7-226 AC Q6FRY6.1
#=GS A0A2H0ZLQ4_CANAR/5-197 AC A0A2H0ZLQ4.1
#=GS A0A7H9HTX1_9SACH/4-156 AC A0A7H9HTX1.1
#=GS A0A9P8THC8_9ASCO/12-221 AC A0A9P8THC8.1
#=GS I2GWV4_HENB6/7-227 AC I2GWV4.1
#=GS A0A1B7TGW0_9ASCO/58-248 AC A0A1B7TGW0.1
#=GS A0A1L0BQW6_9ASCO/4-114 AC A0A1L0BQW6.1
#=GS A0A1E3QJV3_9ASCO/12-208 AC A0A1E3QJV3.1
#=GS A0A8J5UXG7_9ASCO/23-203 AC A0A8J5UXG7.1
#=GS A0A367YEH8_9ASCO/38-216 AC A0A367YEH8.1
#=GS A0A1G4MDD8_LACFM/7-226 AC A0A1G4MDD8.1
#=GS J4U1Z8_SACK1/24-245 AC J4U1Z8.1
#=GS A0A2P7YXU5_9ASCO/694-881 AC A0A2P7YXU5.1
#=GS G8BQG7_TETPH/7-275 AC G8BQG7.1
#=GS A0A9P8TQQ3_WICPI/17-251 AC A0A9P8TQQ3.1
#=GS G8ZUU6_TORDE/7-214 AC G8ZUU6.1
#=GS H2ANU6_KAZAF/7-205 AC H2ANU6.1
#=GS Q6CPY4_KLULA/7-208 AC Q6CPY4.1
#=GS C5MD70_CANTT/22-216 AC C5MD70.1
#=GS A0A1D8PE34_CANAL/6-270 AC A0A1D8PE34.1
#=GS PSY3_YEAST/7-227 AC Q12318.1
#=GS A0A1E4SDF5_9ASCO/3-88 AC A0A1E4SDF5.1
#=GS A0A9P4M096_9PEZI/148-308 AC A0A9P4M096.1
#=GS J8PZ32_SACAR/7-227 AC J8PZ32.1
#=GS A0A1G4IND6_9SACH/7-231 AC A0A1G4IND6.1
#=GS A0A061B2Q2_CYBFA/3-185 AC A0A061B2Q2.1
#=GS A0A0C7N1M6_9SACH/7-232 AC A0A0C7N1M6.1
#=GS A0A367XRQ3_9ASCO/39-216 AC A0A367XRQ3.1
#=GS D8FGE4_EREGS/7-215 AC D8FGE4.1
#=GS A0A1X7RAK3_9SACH/7-215 AC A0A1X7RAK3.1
#=GS J7R2J2_HUIN7/7-203 AC J7R2J2.1
#=GS A0A1E3PAU5_WICAA/7-222 AC A0A1E3PAU5.1
#=GS A0A1E4RUT5_CYBJN/3-108 AC A0A1E4RUT5.1
#=GS A0A7H9B4X2_ZYGMR/7-214 AC A0A7H9B4X2.1
#=GS A0A4P6XSY0_9ASCO/3-125 AC A0A4P6XSY0.1
#=GS A0A1E4RC66_9ASCO/43-172 AC A0A1E4RC66.1
#=GS G8JQ08_ERECY/7-221 AC G8JQ08.1
#=GS G0WH23_NAUDC/7-268 AC G0WH23.1
#=GS M3HEE0_CANMX/3-154 AC M3HEE0.1
#=GS Q6BK21_DEBHA/47-194 AC Q6BK21.2
#=GS A5DTZ0_LODEL/1-223 AC A5DTZ0.1
#=GS A0A1E4RU86_CYBJN/9-211 AC A0A1E4RU86.1
#=GS A0A9W6YZ87_AMBMO/2-145 AC A0A9W6YZ87.1
#=GS A7TQ53_VANPO/1-107 AC A7TQ53.1
#=GS C4R0V5_KOMPG/7-178 AC C4R0V5.1
#=GS C5DRC4_ZYGRC/7-212 AC C5DRC4.1
#=GS A0A2V1ANR6_9ASCO/618-796 AC A0A2V1ANR6.1
A0A1E5RI48_9ASCO/117-297 .............................................................qrekecsdedla------------------.------.................---.----------------......-----.-------........-ETDKYVVILII...........DVASSWHTICP................................aMTFDKDTGITIIRqrfET..SIMsEL.SQLLSFLSN.TVLD..iSKFKLY.-LQK.....NFNIPDy..yQLGAIVIDNLS.YFnfdfstaaspcslshaitqmf...............nnstyhhffsynfxvklplpgEADNTE........SLNNLMQLLH...NIRDRYGALAITVSFDNRF--------.......------------.........--------------------f.............................
G8Y141_PICSO/1-220 ..................................mktktlldffeiqkqeitlplldpsgthvklqgqlchll------------------.------.................---.----------------......FEDRH.SKKELF-........KSIKEPNTIAIF...........DCGRNGFSYLP.................................------DNFEVLD...NF..S--.SL.DELLSSLED.ILD-...----IK.AC--.....HPLYHK....SLNTIIIDNLSvYYwdlkllnsn......................................tapagctyklKCHGND........YYLKLLSVLK...KIKQKTQCNIITTSWSNTFEKGYNYSNa.....eNKTIEGSDHDTEvd.....kfTFLPKQYLASFDFLIHS---qf............................
C5DFB4_LACTC/1-169 .....................................................................mtki------------------.------.................---.----------------......-----.-KSSVVHr.....liDELPNQTFVLMI...........DIASCWREFAT.................................EYSHEEKSVAYMN...SA..SLL.HF.ESLINFLAQ.LNDN...PQEALS.RCKQ.....AAPLQF....QLASIVIDNIS.YY.........................................................THDNAS........-YELLFKILR...MLRSRYGCSVMTVGFGLDFYNGVEQSF.......AT-NKSYDI--P.........TRLPMSYVKNMDCVLQRD--na............................
A0A512UIL2_9ASCO/126-244 ..................................................cgtpeelisvikgipenktpsig------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-------------...--..---.--.---------.----...------.----.....----SC....KLNTVVIENLSaFYw......................................................dkQ---RVprg.savqWYVEIGHWCG...VLQQKYGCNVVVTMWDKNFERGFNSRP.......------------.........--------------------vnelhprklddlsytpaelfavascilafr
G8Y426_PICSO/1-220 ....................................................................mrtkt-----LLDFFEIQKQEIT.LPLSDS.................-SG.THVKLQNQLCHLL---......FEDRE.SKEELF-........KSIKEPNAIAIF...........DCGRNGFQYLP.................................------ENFEVLD...NF..S--.SL.DELLSSLED.ILDI...-----K.AC--.....HPLYHK....SLNTIIIDNLSvYYwdlkllnsn......................................tipagctykhKCHGAD........YYLKLLTVLK...KIKQKTQCNIITTSWSNTFEKGYNYSNaes.ktiEGSPNDTEVDKF.........TFLPKQYLASFDFVIHS---qf............................
A0A1G4JER0_9SACH/7-239 .........................................................................CRVYPLSTFYDPTAISID.WLYKDLfgktvfdfdeddstsnlESS.KRKLGPIAFLHLIEHT......FKVST.FKLNLLKk.....lvQSSPSQSFVLII...........DVMSCWHELIP.................................SLSVEDRSAVYMN...SS..SLL.HF.DALVNFLSQ.LNEN...PPEALS.RCQS.....PVNMQH....QLAGIVIDNIS.YY.........................................................THDSAS........-YDLLFKLLR...MLRKKYGCYTVTVGYGLEFYNGVEQQQ.......PL-APSQGYDIP.........TRLPMSYVKNMDCVVLRETD..............................
A0A9P0QTH2_9ASCO/1-204 .......................mkikklrelievpkaelvlhtrssevtlrnqtchtlfkthseknsfyssl------------------.------.................---.----------------......-----.-------........---SKNSEVLIF...........DC-----D---.................................-LNLSSKESGYDN...IV..SIY.SS.AELLQQLTQ.LYLN...PSTPLS.----.....----LQ....QLRLVIIENISvFY.........................................................WTLKLGrd....lnYYVQLADLLS...KITQKYGCNAIVTSWDNDYERGYNYNRq.....rSGNEAHGDVQKDpnqhtlqnvSYLPRQYYDRVDLVT-----hyg...........................
G0VKS3_NAUCA/20-233 .........................................................................CRVYPLSNFYHPSPQSIT.LPNTLI.................SNT.DNDKPHIGLLHLIEHD......FKMSN.FKKQLFN........HLTTSNASYLII...........DITSTWKRFLL.................................SSSSASASLMYMN...ST..SIL.SF.EGLINYLVQ.LNDH...PTTALQ.RSLS.....INNEPLqltlPLSGIIIDNLS.YL.........................................................PQDPPQ........-FKILTNILK...LLRKSLGCWIMTTSYGLEYNQGIENTI.......STSASNSN----.........TYIPLNYTKEMDIVLLHERD..............................
Q6FRY6_CANGA/7-226 .........................................................................CRIYPISSFCATTETYFK.IPEDLV................nQHL.ALRTRKLGHIHVVEHS......FRLSK.VKKKLIT.......tNLDENSGLILLI...........DVISCWKQFAR.................................SLVNNGQSIAYLS...SA..SLC.QF.DGLLNFLGQ.LIDS...PDEALK.RCIF.....TDSYSCl.qqPLTGIIIDNLS.YY.........................................................QTPVAM.......rEFSALQKMLK...SLRSTFGCWTMTTSYGLEYYNGVEGGT.......STLYTSSGTSF-.........TRLPVSYIKDTDLVLMRDTE..............................
A0A2H0ZLQ4_CANAR/5-197 alakfialessllrvtlsleeqelrnesavilfqnlalkkrfyeklrpekgsivvfdsgagfmdsanivgscv------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-------------...-I..RIE.HF.DDLLSKMNG.LMND...EVKEVN.----.....----EL....HLNTLIIENIStFYwt....................................................lrsS----Shr....nlSYSKLRDLVD...TVKEWYKCNVIVTTWDSEFEKGYNLKR.......AN-ENPQKLGEL.........TFIPAEFYQKFDHIVA----vgqk..........................
A0A7H9HTX1_9SACH/4-156 ..................................................................cgnrsdl------------------.------.................---.----------------......-----.-------........-------TFLVV...........DIVSEWETMLY.................................---DCNMGFYVMN...ST..SIH.NM.EGLVNFLLQ.LNES...PREALM.RCRI.....KDSQSK....QLAGIVIDNIS.YL.........................................................SHDVNS........-YNLLIRTLK...MLRNTFGCWILTVSYGLEYYNGVENAL.......ASPHRAGSL---.........TRVPLGYTNEMDAMIIRDTD..............................
A0A9P8THC8_9ASCO/12-221 .........................................................lrnvqqlfqcpflski------------------.------.................---.----ETSTSIHFIEQY......QKIAHvLIAQLIId.....hyEKESGSGITILV...........DLTYSWNTNNKcyri........................ieqrlKSLNKSSHLIIVR...--..NIN.NF.TDLLRLLKS.IQDT...TYFK--.--NK.....PELLDF....PISSIFIDNISvFYwe....................................................cliSENIEQ........EYNGLASILM...KLKSFYGSSIITTSWDKDFDQSPLNTF.......KS--AKPDVLNY.........CNLPMKYLCSFRHV------yflkk.........................
I2GWV4_HENB6/7-227 .........................................................................CKIYPLSKFYKPNYQYYQ.LPPGIK.................PNE.NLDTSKISKLHLIEYG......FEITP.LKRSLLTt......mLMMEDVGNVLII...........DIVSIWLGTIE................................mMNMKQKKKINYLN...CI..S--.NI.KELNNFLSQ.LIET...PIVALR.RCQQ.....FENVDEviqrRLDGIFIDNVS.YL.........................................................QDFNEDqkg..nsqMYDELNKMIR...KVREVFGCWVVSISYGNEYYEGVEGCL.......NV--KSHSI---.........SGVPISFLNGMDMIVLRESE..............................
A0A1B7TGW0_9ASCO/58-248 ............................................fvhvilengfdvayqrflidklshidknn------------------.------.................---.----------------......-----.-DKPILT........NTFNSKKLVLIF...........DLNTAWRDSITnekdgimny..............rfkqendtffLRIPYLDIINQQE...EI..LLA.DVqNSFISFLQKnFLDS..qDIDNFF.NELN.....ISTTEY....HLSAVIIDNLS.MLsiyeepqn.........................................ielmklrrP-DNSK.......dNELVMMDFLK...DFYHLFGCLVITIGFNI----------.......------------.........--------------------..............................
A0A1L0BQW6_9ASCO/4-114 ...............................................................lrgipndqde------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-------------...--..---.--.---------.----...------.----.....--EISK...rHLNTLVVENISaFYwnl..................................................atlsSQEKFS........WYKGLNNELA...QIRKRYGCNVLVTGWDIDFDRGFNARR.......VIEKAPVALQDL.........TYLPGELFLGATRIIH----yget..........................
A0A1E3QJV3_9ASCO/12-208 ........................................................lssivapsprlnryltd------------------.------.................---.-LLHADVHFAHLIFSS.....pRRQVE.VLKTIV-........--SQASDAVLVF...........DCGYSWQSPSE.................................--------TVVFR...GT..--E.TL.GQLVEALS-.-IES...VCATLA.HV--.....--S-HH....SLETIVVDNLSvFK.........................................................FQEHGE.......rLYPALVDALQ...VLHGYFGCTIICTSWDASFDEGYKMIPtrafkytERVEK------KrevhiwqkfSQLPASVLCRFDAILA----fhgt..........................
A0A8J5UXG7_9ASCO/23-203 ..........................kvtllpnqlylhlcsnrriirhvidelykhqqattytiscmdgsiqs------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-------------...--..---.--.NSIVQTFTQ.LLIK...LRQIAN.-G-D.....FEFNDQ....VVNTILIHNLTaFYwdliivdkf......................................nyqqlgfdniLRPPQF........YYLNLFRILQ...VIVTKYNCNVVVTAYDIVFNNGIKENI.......AP-VRDTSLQRY.........TKLDPSFVLHFDQILHI---dni...........................
A0A367YEH8_9ASCO/38-216 ......................................dksslnnyilprltthkattlviscmdndtirknf------------------.------.................---.----------------......-----.-------........------------...........-----------.................................---------DHVV...QS..--R.SF.PETIKILED.LYNC...DRKS--.QY-V.....LGLLDT....EINHVIVHNISaFYfdlevldkyn.....................................ykklgfryynP----Sip...hdrYYDSLAYLLK...KVCEKYRCTGIVTSYDADFNCGMLGTY.......-TYKPVDELQKF.........TKLPVSFIKQFNRAVHFS--qd............................
A0A1G4MDD8_LACFM/7-226 .........................................................................CRVYPLSTFYSPTQIHINsILRDNYgn............vvdGED.GTLVENVGYLHLIEHR......FVLST.FKSKLMRq.....ilEQLPSQTATLII...........DIVSGWKEFST.................................TINVDEKQIFYMN...SP..SLL.HF.DTLINFLVQ.LNED...PEEALR.RCSS.....GYSVDL....QLATIVLDNIS.YY.........................................................THDNAS........-YHLLFKVLR...MLRQNYGCAVVTVGYGLEYYDGVEK-Y.......SESRQSF--DIP.........TRLPMSYVKNMDCVLVRDTD..............................
J4U1Z8_SACK1/24-245 ........................................................................i-RVYPLSNFITSSKTYIK.LPNELR................nLTT.KEQEDQLGFLHIIEND......FKPSA.LLQKLV-........DYTADEGKILII...........DIVSLWSQQ--.................................--KQRQPGAIYMN...SL..SCI.NI.TGLIAFLEL.LYDS...PMDALR.RCQ-.....VDRFDF....QLRGIVIDNLS.FL.........................................................NFENDNnynvinlsKFEKLFKILR...KLREFLGCWIITKSFPMEFYNGIENSLvd...kwS-IKRKGGVAQY........pTRLPESYMKGMDLVVCKE--va............................
A0A2P7YXU5_9ASCO/694-881 ..............................................dikrkrklqlnlpweektlenesavfl------------------.------.................---.----------------......FRNIS.FKRAFYD........KLGERDGSILVF...........DCGAGFTDTLN.................................--------LEDCR...VF..HVA.TF.DKLLLQLRG.IMAG...EMEEIK.----.....----DM....HLNTLVIENVSsFF........................................................wTLQREKlt....vmRYCKLRDTLN...ELKECYQCNVIVTGWDIEYERGYKP-F.......KAIADPSKLHHL.........SLLPSEFFQTFDHIVA----fgrh..........................
G8BQG7_TETPH/7-275 .........................................................................CRVYKLSSFKNPTEQFIK.LEKNEInit...........nnpVSL.SLILDKIKYLHLIEHE......FKLSN.FKCSLAQsciknlqaDGKGNEKCILVI...........DIISAWKKYLLnkeyiasdvkgssysetdgettshensqipepdSTENNEVGVYYLN...SS..DIL.NM.EGILKFFSK.LNEN...PIETLEkYCHFp...kTVNFKQ....QLSGIIVDNIS.YF.........................................................AHDNHMniq.qntaHYSTLLNMFK...TLRKTFGCWVISVSYGMEFYDGVELST.......SSIYRSGSH---.........TRVPINYTSGMDTILLRDTE..............................
A0A9P8TQQ3_WICPI/17-251 ........................................................itlpyhtslnspypfsg------------------.---QTH................iNKD.QNSNNNSTLIHIIDTSs....kVRHG-.VIKDIILet...yntTSSNSPGITVIF...........DLLDHWTMNNLnfse.........................iqsqLSSDQRERIIVIP...SE..SCD.DF.DSLLLQLSM.IQSGeffPKEL--.RCH-.....------....SVSLVIIDGLN.LLnwgvikdckpnkv...............................kipggkdqdqdilK----Vl.....seNYRLLSALLL...EIRSFYNCSIITTSFDHTY--GIKT-F.......SN--GSKKLQS-.........--------------------nptlrdelsytsgtgi..............
G8ZUU6_TORDE/7-214 .........................................................................CRIYPLSSFYHPAQWFIE.LAGLVT.................--T.DNELKPVGLLHLIEHS......FKTST.FKRDLFLq......cAGDRDDSSILVI...........DIVSEWKSLLK.................................---NYGVGVHVMS...ST..SIL.NI.DGLISFLLQ.LNES...PREALK.RCQR.....RDSLSK....QLSGIVIDNIS.YI.........................................................VHDPGS........-YNLLLRTLK...MLRNTFGCWIITISYGLEFYNGVENST.......ASLYRSGSI---.........TRVPISYTNEMDAMIIRDTD..............................
H2ANU6_KAZAF/7-205 .........................................................................CRIYPLSNFLKPKRNAIN.LEGLNIn..............nsNDI.TINNNESQSLHLIEHS......FRKSK.FKEQLV-........--SNNFEHIIII...........DIISIWQD---.................................------DKFNVIN...--..SIY.TF.NELINFLTK.FNDS...PLATLS.EY--.....GISMDT....-VEGIMIDNLS.YI.........................................................GNLNNK........SIVILIKILK...LIQINFGCFILSTSYGLEYYEGIEN--.......--FQRMKNLNLKy.......pTLLPMNYLLEMDTILLRET-g.............................
Q6CPY4_KLULA/7-208 .........................................................................CKVYSLDQFTSPYQYTCE.V-----.................---.--NGKKCTRIHVVQES......LRGNG.KTRTIVNt.....vrEQCEGNGLILNIssmprndhndnDLLETYPEFQQ.................................------------T...NL..SML.QF.DSFIQFMSQ.LCTD...PVTALS.RCQPq..nsETSTSK....QLAWVLIDNLS.HL.........................................................SMDPKF........DAKLLNRSIR...LVQQTFGSVVISTSLPLSFHGGIESTF.......KH-QSTKCASGD.........RLLP--YFNESDIIL-----..............................
C5MD70_CANTT/22-216 .....................esiiltskksclllypdkssflkqvlpqlvkhksttlviscmdndiirkcfd------------------.------.................---.----------------......-----.-------........------------...........-----------.................................----------HVI...T-..-TK.TF.PETIKILED.LFNC...DTSS--.KY-V.....SKFLDV....EIQFIVVHNISaFYydlevldkyn.....................................ykklgfvtynPNIPHE.......yYYNSLGYLLN...KICAKYKCSGIVTSYDLEFNCGVVGTY.......SY-KPQDDLQIF.........TKLPVSFIKLFDMAIH----lnrs..........................
A0A1D8PE34_CANAL/6-270 ....................................lldyhvskstkielglfentlnfsnndyglilypnrk------------------.------.................---.----------------......----T.FRQHILPqln..nnnNNTNATDSILVI...........---SCMDNELLrnnf.........................inivPCKNYPQLIKILQ...--..DLY.NC.NENSPYFDN.TTTT...TTTT--.----.....IQILDK....HINYILIHNISsFFydlqivdqynyqslgfeqfnqpdkspppdqgnnqpygktgkntktniqfnnddndddSTKTHG........YYNLLLTLVK...KINRKYNCLVVLTSYDIEFDSGLVGSY.......LY-NPNHELQRY.........TKLPIPFITRFTSTIH----isnd..........................
PSY3_YEAST/7-227 ........................................................................i-RIYPLSNFITSTKNYIN.LPNELR................nLIS.EEQESKLGFLHIIESD......FKPSV.ALQKLV-........NCTTGDEKILII...........DIVSIWSQ---.................................-QKQRQHGAIYMN...SL..SCI.NI.TGLIVFLEL.LYDS...PMDALR.RCQ-.....VDNFNF....QLRGIVIDNLS.FL.........................................................NFESDKnydvinlsKFEKLFKILR...KLREFLGCWIITKSFPTDFYNGIENTLv....dkWSIKRKSGVTLY........pTKLPDSYMKGMDLIIYRE--v.............................
A0A1E4SDF5_9ASCO/3-88 .......................................................nrsnyrefglkeftstlq------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-------------...--..---.--.---------.----...------.----.....------....-----------.--.........................................................------........LYSTFNDYLD...RVRIKYKCNLVVTSYDINVDKGYKSGF.......KE-VQFKDLDSV.........SFLRGAYLKRFDYILFR---gie...........................
A0A9P4M096_9PEZI/148-308 .........................................imkhyiitcakqqhqhladqddahianllhss------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-----------LT...HL..HIL.RP.QSQSALLAS.LATL...PAYLFN.-ARA.....HHSTHR....PLHALILDSASaFYwpvkaaeetsrlaqp..........................qdqngteneeklhpasS-SPTAs......eSYATLSRTLR...KLQRQLSCTVIVTSTSMPY--------.......------------.........--------------------thpntsatllp...................
J8PZ32_SACAR/7-227 ........................................................................i-RIYPLSNFITSSKNYID.LPNELK.................NLIpEEQEAKLGFLHIIEND......FKPSV.ILQKLA-........DNAADEGKVLII...........DIVSLWSQVKR.................................----RKHGVIYMN...SL..SCI.NL.TGLITFLEL.LYDS...PMDALR.RCQ-.....VNDFNF....QLRGIVIDNLS.FL.........................................................NFENDSnydvinlsKFEKLYKVLR...KLRDFLGCWIITKSFAMEFYNGIENTLvd...kwSMKDKGSVAQYP.........TKLPQSYMKGMDLIVYKE--l.............................
A0A1G4IND6_9SACH/7-231 .........................................................................CKVYPLSTFYRPAQVSIN.WIARDNfgnvv.......eggesGDG.NVGVGDVGFVHLIEHD......FKISE.FKGRMALr.....lvEQLPSQASILIV...........DVVASWRKWLD.................................AHAHVRARAHYLT...SP..SLA.RF.ETLIAFLNQ.LNET...PADALR.RCTV.....QQPLDM....QLGAIIIDNIS.YY.........................................................VHDSAT........-YEILLKTLR...RLRQNYGCIVLTTGYGLEFYDGVENS-.......-QRQPNQTLDIA.........TRLPMSYVKNMDCVLVRDT-a.............................
A0A061B2Q2_CYBFA/3-185 ..........................................................snsgyifdllkdnve------------------.------.................---.----------------......-----.-------........ERNLEDSAIVVF...........DLDYTWVHKDHryq...........................hiaAIGDVPTKTHIII...KN..GVT.SL.GDLIKNLRS.LQAG...ELLTS-.----.....SAQSTL....PISLVIINNVSvFDw......................................................nmSY---Egs...laeEYEALTSSLK...KLQKELSCSVIVTAKDIGFTTGIVKPK.......PRRNARFTILKE........nTGAPSVFTSIFDHIIYLHT-e.............................
A0A0C7N1M6_9SACH/7-232 .........................................................................CRVYPLSTFYKPVAINID.WLGKDSfgnai.......ldceqQPG.AQKLKPAGFLHLIEHS......FTPTT.FKEELLTr.....lvDNCPDQSFILVI...........DLISCLKPLLS.................................QLQLDDKDVAYLN...SA..SLV.NF.DSLINFLVQ.LNES...PQDALS.RCRK.....QVSLQY....QLAGIVIDNIS.YY.........................................................THDAAS........-YDLLFKVLR...LLRARYGCCIVTVGYGLEFYNGVEKGL......aETSVQPYE--IP.........TRLPISYVKNMDCVLLRDTE..............................
A0A367XRQ3_9ASCO/39-216 ...............................ksslnnyilprltihkattlviscmdndiirknfdhvvqsrs------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-------------...--..---.-F.PETTKILED.LYNC...DRKS--.QY-V.....LGLLDT....EINHVIVHNISaFYfdlevldkyn.....................................ykklgfrhynP----Sip...hdrYYDSLAYLLK...KVCEKYRYSGIVTSYDVEFNCGMLGTY.......-TYKPLDELQKF.........TKLPVSFIKQFNRAVYF---sqd...........................
D8FGE4_EREGS/7-215 .........................................................................CKIYSLARFVHPRQHSLD.WLAPGT.................---.-APRKSVHVVHVVERTmgelaaWRPRT.LARLL--........----EGGAVVIV...........DCVAVWGRAVA.................................-QHASSGRIHYVR...DA..GVL.SF.SGLLGFLAQ.LADA...PAATLRrRCRA.....PATAPA....PLAAVVLDNIS.AY.........................................................RAPPAA........-LGALRRALE...HLQLAHGCAVLTVGYGIEYYEGVESSF.......PT--RAGEV-GPw.......pTRLDHAYLASMDAVVVPATE..............................
A0A1X7RAK3_9SACH/7-215 .........................................................................CKVYSLSQYYHAQRQLLT.I-----.................---.DAKTEPVRSLHLIEPD......FKIYD.FKRQLLK........DNVTTNGKILII...........DIVSTWRNTLI.................................NDAKLLNNIWYIN...SE..ELF.TL.EGIICFLAR.LNAN...PSNTLHnECSIdkdqtKSNTDDs..iSLQGIIIDNLS.YL.........................................................YAGTANd.....ikSLNILLKLIK...NIQRTFGCWYVSTSLNNEFYQGIEHSF.......TS---QNN----.........-TIMSSYMNDIDLVMVRD--p.............................
J7R2J2_HUIN7/7-203 .........................................................................CKVYPLGKYITPAQRSLD.LPPAGH................tITN.GKPHSTHSRVHIIVKD......IRHGQ.IIQDIL-........TQSAGHGCVLVV...........D---NYGNNHP.................................PSAKDTHTVRHLV...SS..T--.RV.EDLTAYLRD.VPSQ..lPTEA--.RTM-.....------....PLQGIIVDNLSlCR.........................................................RSRGPG........ADAQLLETLR...KLQRRYGCWVVTVSYGIGF--------.......ATAGGQQLAQTAy.......pTSLPLQYLNECDTVLYTET-r.............................
A0A1E3PAU5_WICAA/7-222 .....................................................................ikpv----SLKNFVRPIQHEIQ.CPFTNT.................---.----RECTIIHMIDQPq....pIRHKY.ITEVILNyi....ktCMEGAIGRIIIF...........DTYYVWNTKNKyfnk.........................ltssLSPEQADRIRIVN...TR..N--.ST.AAIIKSMVS.LKDP...DSPLLE.KS--.....--DAEV....PIGLVIIDNIStFY.........................................................WGTKQQgt...lvqEYKALGSVLK...KTQSTLGCSIISTSWDKKF-----NIL.......QDTNSENELELK........yTAIPKEFFQFTDQI------ysfs..........................
A0A1E4RUT5_CYBJN/3-108 ...................................................................mleykl------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-------------...--..---.--.---------.----...------.----.....-DRMDL....PLKLLVIDDLSvFHwd....................................................llvDGTLEE........EYTALAKILQ...RLRHQFGTAIVTTSLGVEFESGMTLQH.......HRHHQNKPVYCQ........wSCIPPVFLQQTHDIVLA---tda...........................
A0A7H9B4X2_ZYGMR/7-214 .........................................................................CRVYPLSNFYKPVNQFVS.LPQNTV.................-KG.TLFCKEIAFLHVIEHD......FKLST.FKKQLYL.......nCKSNGNSTILLI...........DILSAWKEFIN.................................---STNDELFVMN...SL..SIM.TM.DGLVNFLLH.LNES...PLYALK.RCQK.....RDSFDK....QLSGIIIDNIS.YF.........................................................AHDPTS........-YGLLLKVLK...LLRKTFGCWIITISYGLEYYNGVENAT.......SQLYKGGS---Q.........TKIPTGYINEMDVVLIRDTD..............................
A0A4P6XSY0_9ASCO/3-125 ..................................................................fvhcgsp------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-------------...--..---.--.DGLILALKG.MLDT...TDPILG.HC--.....------....VLNTIIIENLSaYYwdl..................................................kchpRQEAVK........WYLELLQLCH...VLKERYMCNVVVTMWDKNFERGFNSRA.......VSNLEPRKLDDL.........TYTPMEFFQNADYVLA----ara...........................
A0A1E4RC66_9ASCO/43-172 ........................................................rnwyerlditnnitinc------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-------------...-G..TLL.TF.QDLMNEMNG.IMEN...YDSGM-.----.....------....VLRLIIIEDLSsFY.........................................................WEFKSR........HYQEIFSMID...KLRNKYGINIIITNWNNNYERGYNYKL.......KPSGTPNNLNDV.........TFVNNEFIKKLDYV------gyinnd........................
G8JQ08_ERECY/7-221 .........................................................................CKVYPLDRFLKPHLYTLN.WLPELS.................--V.DDKRKPVRFLHIVEKSmglldrWKASF.LRQLL--........-DQNDPATVLVI...........DAISIWSRMLP.................................--HKSESQVHYLN...NP..SIL.QF.SGLVGFLAQ.LCES...PDLALRsRCDI.....HASLDA....PLKTVILDNLSaYY.........................................................FQENAS........-LETLRKLLE...TLHATLGCAVVTFGYGIEYYEGVDNTY.......PT--RPSEIKGPw.......pTRLDYSYLKAMDSVLVFTQ-d.............................
G0WH23_NAUDC/7-268 .........................................................................CRIYPLANYIRPELKFIN.ISNDLIinnnksiisvndhldddKND.DNNTNKVALAHLIEHE......FKLTT.FKKKLLIdli.tipnHEKNGKNSYLII...........DISSTWKQYLIelf..........................drenNQTNFTTSINYMN...SF..SIL.NM.DGLINFLMQ.LNGS...PIDALK.RCQQypstsSDSIDQ...yQLSGIIIDNLS.YI.........................................................SSSSSSs.....tsTFPLLLKLLK...LLRKSFGCWIFTTSYGISYYKGIENSL.......ESSPSSSSIHLQqhs..kklpTYFPESFINGMDMILLHETE..............................
M3HEE0_CANMX/3-154 .............................................................nelmrnnyqnvi------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-------------...--..FAD.TF.AQMIKILED.LYNC...DPES--.KF-V.....SHVLDK....EIKMILLHNVSaFYfdfqvldqyn.....................................ytdlgfskfnKNIPEE.......hYYKNLSYLIK...KINAKYNCLSVVTSYDYEFNCGLQGSY.......QY-NPKDEYQKF.........TKMPSTFVKSFDTAVHI---nkn...........................
Q6BK21_DEBHA/47-194 ................................................................gdkciinsg------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-------------...--..-FA.TM.DQLLDNLRH.ILAI...GTDG-D.--TT.....HPLYNK....TVNTVIVDNLSvYYwdlkllnsdp.....................................knheqlgyacKASGLE........YYTKLISVLQ...EIQAKFKCNIVTSSWNNTFEKGHNYSG.......ATDCEATGLDSI.........TFLPQKYLMEFDYLIQK---sng...........................
A5DTZ0_LODEL/1-223 .........................................................................MKISNLTDHIEFQEYSVD.IPSQTG.................---.-------EPIITIKRQetclvlAENQR.IIQTVFVkvl.nkvrADSSTNSILINC...........EGQEYF-----.................................PRREFQNSESITT...EI..NVR.TV.QDLISALEN.ILAC...TSDAIM.----.....--NMER....ELRAILISNISsFYwtlhllnd........................................enyqnlgfkTYIPPS.......nIYLRLSHLFK...HIARKYHCTVIVFGFDFHFDCGLSA--.......DKYCPQSDLQKL.........SKLPSLFLSSFTHIVHK---gr............................
A0A1E4RU86_CYBJN/9-211 ......................................................................ftt-----LRQFISPVERFVA.LPGVIE.................---.-----GSGHLHVVCGD.....hGQRAG.VIRTCIE........SLREANGQTVVV...........D-LGLSSRHLE.................................SQLGGHFGTEITV...RT..DIE.SF.TQLLRCLMD.MLEY...K---LD.----.....--RMDL....PLKLLVLDDLSvFHwd....................................................llvDGTLEE........EYTALAKILQ...RLRHQFGTAIVTTSLGVEFESGMTLKH.......HRHHQNKPVYCQ........wSCIPPVFLQQTHDIVLA---tda...........................
A0A9W6YZ87_AMBMO/2-145 .....................................................................glvr------------------.------.................---.----------------......-----.---ELILn.....kfRNANDKEMIIII...........DCAYQFGNKELpnsf........................mfsiyKELWLQNGVSVTE...AFfkRIL.VF.RDFN-SLKD.VNNL...LEHLLE.RI--.....PKNFRE...yQLGTVVVSNTSiFY........................................................wSLRNDG........DNETLNKFYKncqLVSQKFHCPIISCQ-------------.......------------.........--------------------htln..........................
A7TQ53_VANPO/1-107 .........................................................................------------------.------.................---.----------------......-----.-------........------------...........-----------.................................-----------MN...SN..SIL.TM.DRLINFLIQ.LNES...PIEAFK.KCQF.....VGKSSQ....QLSGIIIDNIS.YF.........................................................THDNNEngiqnaskAYNNLLKILK...LLRKNFGCWIMTISYGMEYYDGVENST.......SH----------.........--------------------lik...........................
C4R0V5_KOMPG/7-178 ............................lkfidlstlcvsrnkhlklpeqnsgqlkffeknqhffdvrvyddi------------------.------.................---.----------------......AWNNY.LLETI--........-KSNTDGVVILF...........DCFLEWHKIQP.................................MFLRGSQSNHLFV...VS..EFT.AI.EELSNKLSK.FEDI...LLK---.-L-D.....VEARKL....PLKGIVLTNMSvYY.........................................................WQSKDNg.....kkTWFSVVDQLE...RLQAKYGCTIIR---------------.......------------.........--------------------gmwdft........................
C5DRC4_ZYGRC/7-212 .........................................................................CRVYPISNFYHAVPQSLT.LPSCIG.................---.---SHCVSFVHLIEHN......FKFTP.FKRQIWNqc....ieCSVNDGSSILVI...........DIISEWKKIIQ.................................---ENSQGVHYMN...ST..SIC.NM.EGLQNFLMQ.LQAS...PLEALQ.RCLI.....KDRLDK....QISGIIIDNLS.YL.........................................................AHDLSS........-YSALIKILK...QLRRTFGCWILTIGYGLEYYDGVENST.......STPNRTGAL---.........TKLPASYINEMDVIILRET-a.............................
A0A2V1ANR6_9ASCO/618-796 ...............................................ydelddfdeeinyeiyvvllfqrlsy------------------.------.................---.----------------......-----.-KRAFYQ........KLGQTKGSIIVF...........DCGAGFMDTIR.................................--LEDS----YSV...--..RVS.DF.NDLISQLKG.IMTD...QDKEIS.----.....----DR....EMNTLIIENLSdFYw......................................................tlRSSPQRv......sSYLRLRDLTA...QLKERYQCNIIVTSWDSDFEKGYNLKH.......SN-DDPKKLSDL.........TFIPPDFYTKFDHI------yaig..........................
#=GC seq_cons ....................................................................................................................................................ht.hh.............t.s.lllh...........Dhh..a.p...........................................th.hhs...p...shh.sh.ssLlshLpp.l.ss...shpslp.ph.........thsh....pLssIlIDNlS.aa.........................................................stpstp.........YptLhclL+...pl+ppaGCsllooSash-F.pGhptsh.......tp..psppl............ThlP.sahpphDhllh..................................
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