#=GF ID PanZ
#=GF AC PF12568.15
#=GF DE Acetyltransferase (GNAT) domain, PanZ
#=GF PI DUF3749;
#=GF AU Gavin OL;
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Prosite
#=GF GA 22.00 22.00;
#=GF TC 22.00 22.00;
#=GF NC 21.90 21.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 90746521 --cpu 8 HMM pfamseq
#=GF TP Domain
#=GF CL CL0257
#=GF RN [1]
#=GF RM 25910242
#=GF RT The structure of the PanD/PanZ protein complex reveals negative
#=GF RT feedback regulation of pantothenate biosynthesis by coenzyme A.
#=GF RA Monteiro DC, Patel V, Bartlett CP, Nozaki S, Grant TD, Gowdy JA,
#=GF RA Thompson GS, Kalverda AP, Snell EH, Niki H, Pearson AR, Webb ME;
#=GF RL Chem Biol. 2015;22:492-503.
#=GF DR INTERPRO; IPR040448;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain family is found in bacteria, and is approximately 40
#=GF CC amino acids in length. The proteins in this family are members
#=GF CC of the acetyltransferases of the GNAT family. Family members
#=GF CC such as PanZ has been shown to be involved in the biosynthesis
#=GF CC of Coenzyme A (CoA). CoA is a ubiquitous and essential cofactor,
#=GF CC synthesized from the precursor pantothenate. In all organisms,
#=GF CC the final step in pantothenate biosynthesis relies on the
#=GF CC presence of beta-alanine, which comes from different sources in
#=GF CC bacteria, yeast, and plants. In bacteria, beta-alanine is
#=GF CC derived by the action of alpha-decarboxylase (ADC) enzyme. PanZ
#=GF CC promotes the activation of the zymogen, PanD, to form aspartate
#=GF CC alpha-decarboxylase (ADC) in a CoA-dependent manner. Thereby,
#=GF CC playing an essential role in the biosynthetic pathway to
#=GF CC pantothenate and the regulation of CoA biosynthesis. Structure
#=GF CC and function studies show that direct interaction of PanD with
#=GF CC the PanZ Arg43-Leu46 loop promotes PanD to adopt a reactive
#=GF CC conformation, which leads to activation [1].
#=GF SQ 245
#=GS W1DJ08_KLEPN/2-61 AC W1DJ08.1
#=GS A0A014NBP6_9GAMM/2-127 AC A0A014NBP6.1
#=GS A0A5M7PFB1_9GAMM/2-127 AC A0A5M7PFB1.1
#=GS Q6CZ11_PECAS/2-129 AC Q6CZ11.1
#=GS A0A3M3EIY7_9PSED/2-128 AC A0A3M3EIY7.1
#=GS B2U4D3_SHIB3/2-125 AC B2U4D3.1
#=GS A0A1H6R532_9GAMM/7-136 AC A0A1H6R532.1
#=GS A0A0K1XE38_9GAMM/2-128 AC A0A0K1XE38.1
#=GS A0A0B3BX64_9PSED/2-128 AC A0A0B3BX64.1
#=GS A0A1H0K3T6_9PSED/2-129 AC A0A1H0K3T6.1
#=GS A0A807LIM9_9ENTR/2-125 AC A0A807LIM9.1
#=GS A0A7U7EJS9_9GAMM/2-129 AC A0A7U7EJS9.1
#=GS A0A653WDB1_9PSED/2-129 AC A0A653WDB1.1
#=GS A0A2I0F4I8_9GAMM/2-135 AC A0A2I0F4I8.1
#=GS S2KLB2_LITA3/4-125 AC S2KLB2.1
#=GS A0A4Y7ZTY1_9GAMM/2-138 AC A0A4Y7ZTY1.1
#=GS A0A8J7GWH9_9ENTR/2-129 AC A0A8J7GWH9.1
#=GS E2X8Q2_SHIDY/2-125 AC E2X8Q2.1
#=GS A0A1Z9Z3L3_9GAMM/3-108 AC A0A1Z9Z3L3.1
#=GS A0A0D6STP3_9PSED/2-129 AC A0A0D6STP3.1
#=GS Q9HU40_PSEAE/2-129 AC Q9HU40.1
#=GS A0A1I4YWB3_9GAMM/2-127 AC A0A1I4YWB3.1
#=GS A0A368NKI8_9GAMM/2-127 AC A0A368NKI8.1
#=GS Q8X6S6_ECO57/2-125 AC Q8X6S6.1
#=GS W0HQP9_9GAMM/2-130 AC W0HQP9.1
#=GS A0A143G771_9GAMM/2-111 AC A0A143G771.1
#=GS A0A240ADM3_SERFI/2-129 AC A0A240ADM3.1
#=GS A0A2T0V9W3_9GAMM/3-118 AC A0A2T0V9W3.1
#=GS PANZ_ECOLI/2-125 AC P37613.1
#=GS I2JHY8_9GAMM/2-126 AC I2JHY8.1
#=GS A0A1W6B3J4_9GAMM/2-127 AC A0A1W6B3J4.1
#=GS A0A7T4UR00_9GAMM/2-126 AC A0A7T4UR00.1
#=GS A0A2T5HHS0_9PSED/2-129 AC A0A2T5HHS0.1
#=GS A0A7X3H162_9GAMM/2-125 AC A0A7X3H162.1
#=GS A0A1E7QYY5_9GAMM/4-108 AC A0A1E7QYY5.1
#=GS A0A2N0WVV4_9GAMM/2-137 AC A0A2N0WVV4.1
#=GS A0A511UQ83_9GAMM/3-124 AC A0A511UQ83.1
#=GS W0LDL3_9GAMM/2-129 AC W0LDL3.1
#=GS A0A7X4W0Y8_9GAMM/11-127 AC A0A7X4W0Y8.1
#=GS R8ASS8_PLESH/2-128 AC R8ASS8.1
#=GS A0A4P8QSL3_9GAMM/2-129 AC A0A4P8QSL3.1
#=GS A0A1M7HQA6_9GAMM/2-131 AC A0A1M7HQA6.1
#=GS A0A4U9D841_RAOTE/2-125 AC A0A4U9D841.1
#=GS D8MY72_ERWBE/2-127 AC D8MY72.1
#=GS A0A4R1NE46_9GAMM/2-130 AC A0A4R1NE46.1
#=GS W1DGF1_KLEPN/1-58 AC W1DGF1.1
#=GS A0A1G9E4A1_9GAMM/9-106 AC A0A1G9E4A1.1
#=GS A0A0H2Z3T0_ECOK1/2-125 AC A0A0H2Z3T0.1
#=GS A7ME89_CROS8/2-125 AC A7ME89.1
#=GS A0A0H3CQU1_ENTCC/2-125 AC A0A0H3CQU1.1
#=GS A0AA37SEC9_9GAMM/2-147 AC A0AA37SEC9.1
#=GS A0A7W4W547_9GAMM/2-112 AC A0A7W4W547.1
#=GS A0A1G9QE60_9GAMM/3-128 AC A0A1G9QE60.1
#=GS A0A1S1HND4_PROST/2-131 AC A0A1S1HND4.1
#=GS K6XAM9_9MICO/47-122 AC K6XAM9.1
#=GS A0A6M8U6R6_9GAMM/2-127 AC A0A6M8U6R6.1
#=GS A0A241W3F6_9GAMM/12-109 AC A0A241W3F6.1
#=GS A0A9J7AHB2_9GAMM/2-130 AC A0A9J7AHB2.1
#=GS A0A0X8HBN1_9GAMM/7-105 AC A0A0X8HBN1.1
#=GS A0A9E8JQS9_9GAMM/9-142 AC A0A9E8JQS9.1
#=GS W0HT02_9GAMM/2-130 AC W0HT02.1
#=GS A0A248KGY6_9ENTR/2-125 AC A0A248KGY6.1
#=GS A0AA37TUK8_9GAMM/2-127 AC A0AA37TUK8.1
#=GS A0A1I0AJ49_9GAMM/2-139 AC A0A1I0AJ49.1
#=GS A0A443IEA8_9GAMM/2-127 AC A0A443IEA8.1
#=GS A0A9X3ITX7_9GAMM/2-121 AC A0A9X3ITX7.1
#=GS A0A0L0AUG8_9ENTR/2-125 AC A0A0L0AUG8.1
#=GS A0A1T4NJD7_9GAMM/2-123 AC A0A1T4NJD7.1
#=GS A0A1I7J2V9_9GAMM/2-128 AC A0A1I7J2V9.1
#=GS A0A384LK62_SHIFL/2-125 AC A0A384LK62.1
#=GS A0A2D2MCI6_9PSED/2-127 AC A0A2D2MCI6.1
#=GS A0A4V1IP72_9GAMM/2-121 AC A0A4V1IP72.1
#=GS A0A5R9LMZ7_9ENTR/2-125 AC A0A5R9LMZ7.1
#=GS A0A0J5KZK3_PLUGE/2-125 AC A0A0J5KZK3.1
#=GS A0A380PG60_YERPE/2-129 AC A0A380PG60.1
#=GS A0A0C4WK31_9GAMM/2-129 AC A0A0C4WK31.1
#=GS A0A0H3H464_KLEPH/2-125 AC A0A0H3H464.1
#=GS A0A839IP29_9GAMM/2-122 AC A0A839IP29.1
#=GS N8Y4S1_9GAMM/2-112 AC N8Y4S1.1
#=GS A0A0L7T6T6_9GAMM/2-127 AC A0A0L7T6T6.1
#=GS A0A4Z0MW02_SALET/2-125 AC A0A4Z0MW02.1
#=GS A0A845SU55_9GAMM/2-130 AC A0A845SU55.1
#=GS H2IWL1_RAHAC/2-124 AC H2IWL1.1
#=GS A0A510X9I4_9GAMM/3-108 AC A0A510X9I4.1
#=GS A0A090V3K3_PSEVU/2-125 AC A0A090V3K3.1
#=GS A0A085VGZ4_PSESX/2-125 AC A0A085VGZ4.1
#=GS A0A084A1L1_9GAMM/2-129 AC A0A084A1L1.1
#=GS A0A0H3FKQ5_KLEAK/2-125 AC A0A0H3FKQ5.1
#=GS A0A8H9YX05_9PSED/2-125 AC A0A8H9YX05.1
#=GS A0A2T5PA26_9PSED/2-129 AC A0A2T5PA26.1
#=GS Q3YW69_SHISS/2-125 AC Q3YW69.1
#=GS A0A222FG48_9GAMM/2-133 AC A0A222FG48.1
#=GS A0A0B7G8Z6_KLEVA/2-125 AC A0A0B7G8Z6.1
#=GS A0A1H1WLN3_9PSED/2-126 AC A0A1H1WLN3.1
#=GS A0A1K1W7F2_9GAMM/5-116 AC A0A1K1W7F2.1
#=GS A0A078LQV1_9PSED/2-129 AC A0A078LQV1.1
#=GS A0A5S9N990_9GAMM/2-126 AC A0A5S9N990.1
#=GS A0A097R7A6_HAFAL/2-136 AC A0A097R7A6.1
#=GS A0A662ZF60_9GAMM/18-122 AC A0A662ZF60.1
#=GS A0A198FNZ0_9GAMM/2-130 AC A0A198FNZ0.1
#=GS A0A0N0IBQ6_9GAMM/2-129 AC A0A0N0IBQ6.1
#=GS A0A1X7APY1_9GAMM/2-121 AC A0A1X7APY1.1
#=GS V2UGZ2_9GAMM/2-114 AC V2UGZ2.1
#=GS A0A2T4J7S6_FUSBL/194-270 AC A0A2T4J7S6.1
#=GS A0A3E0H8N2_9GAMM/22-111 AC A0A3E0H8N2.1
#=GS A0A1I1H2D6_9GAMM/7-138 AC A0A1I1H2D6.1
#=GS A0A1G7UYT3_9GAMM/3-119 AC A0A1G7UYT3.1
#=GS A0A0C5VDJ7_9GAMM/9-122 AC A0A0C5VDJ7.1
#=GS A0A7Y3XAV9_9GAMM/4-129 AC A0A7Y3XAV9.1
#=GS A0A1N7NJ73_9GAMM/2-98 AC A0A1N7NJ73.1
#=GS A0A2N7ULF8_9GAMM/3-129 AC A0A2N7ULF8.1
#=GS A0A071LTW9_9ENTR/2-125 AC A0A071LTW9.1
#=GS A0A095TS71_9GAMM/2-126 AC A0A095TS71.1
#=GS A0A5M7QGI2_9GAMM/2-127 AC A0A5M7QGI2.1
#=GS A0A5R9QJ07_9GAMM/2-129 AC A0A5R9QJ07.1
#=GS A0A2N7TGK5_9GAMM/8-112 AC A0A2N7TGK5.1
#=GS A0A0H3DUE1_EDWTF/2-129 AC A0A0H3DUE1.1
#=GS A0A2I5T2X2_SERS3/2-129 AC A0A2I5T2X2.1
#=GS A0A7M2V609_9ENTR/2-125 AC A0A7M2V609.1
#=GS A0A0Q4NPP5_9GAMM/2-127 AC A0A0Q4NPP5.1
#=GS V2UWG3_9GAMM/2-116 AC V2UWG3.1
#=GS A9MM82_SALAR/2-125 AC A9MM82.1
#=GS R4YK43_OLEAN/2-127 AC R4YK43.1
#=GS A0A420ELA2_9ALTE/2-122 AC A0A420ELA2.1
#=GS A0A1T1HBP9_OCELI/2-137 AC A0A1T1HBP9.1
#=GS B7L5R2_ECO55/2-125 AC B7L5R2.1
#=GS B4EX09_PROMH/2-130 AC B4EX09.1
#=GS E3GAY4_ENTLS/2-125 AC E3GAY4.1
#=GS A0A839VI77_9GAMM/2-109 AC A0A839VI77.1
#=GS A0A1B7JYH8_9GAMM/2-131 AC A0A1B7JYH8.1
#=GS A0A7Y8X4W4_9ACTN/86-162 AC A0A7Y8X4W4.1
#=GS D4E0A0_SEROD/2-129 AC D4E0A0.1
#=GS A0A542CV70_SERFO/2-129 AC A0A542CV70.1
#=GS A0A378AMH1_KLEPO/2-125 AC A0A378AMH1.1
#=GS A0A0M2KGV9_9GAMM/2-127 AC A0A0M2KGV9.1
#=GS S3MR44_9GAMM/2-110 AC S3MR44.1
#=GS A0A1H4EPM9_9GAMM/2-129 AC A0A1H4EPM9.1
#=GS A0A4Z0W700_9GAMM/2-106 AC A0A4Z0W700.1
#=GS A0A291P2U5_9GAMM/3-115 AC A0A291P2U5.1
#=GS A0A0G4JSM8_9GAMM/2-129 AC A0A0G4JSM8.1
#=GS Q1R076_CHRSD/7-121 AC Q1R076.1
#=GS A4VRW7_STUS1/15-142 AC A4VRW7.1
#=GS A0A918K3C2_9GAMM/2-113 AC A0A918K3C2.1
#=GS A0A1H2EJ22_9GAMM/2-125 AC A0A1H2EJ22.1
#=GS A0A6I4V6Q5_9GAMM/2-127 AC A0A6I4V6Q5.1
#=GS A0A0P7E7B5_9GAMM/6-121 AC A0A0P7E7B5.1
#=GS A0A1M5EEF7_9GAMM/10-135 AC A0A1M5EEF7.1
#=GS A0A2I0CNW9_9PSED/2-125 AC A0A2I0CNW9.1
#=GS A0A1S8CFU8_9GAMM/2-129 AC A0A1S8CFU8.1
#=GS A0AA37EXJ8_9ALTE/9-121 AC A0AA37EXJ8.1
#=GS A0A562IKI6_9GAMM/2-116 AC A0A562IKI6.1
#=GS L0M0P9_ENTBF/2-125 AC L0M0P9.1
#=GS A0A485AP43_KLUCR/2-125 AC A0A485AP43.1
#=GS A0A4P8YGP7_9ENTR/2-125 AC A0A4P8YGP7.1
#=GS A0A369KVI9_9GAMM/7-107 AC A0A369KVI9.1
#=GS B7UL10_ECO27/2-125 AC B7UL10.1
#=GS A0A085G013_9ENTR/2-125 AC A0A085G013.1
#=GS A0A0L0GWA7_9ENTR/2-125 AC A0A0L0GWA7.1
#=GS A0A941ZAR2_9ENTR/2-125 AC A0A941ZAR2.1
#=GS A0A7Z0RUT2_9GAMM/8-119 AC A0A7Z0RUT2.1
#=GS A0A2G8EHJ7_9GAMM/2-127 AC A0A2G8EHJ7.1
#=GS K2JEG4_9GAMM/2-122 AC K2JEG4.1
#=GS A0A379A9K0_ENTAG/2-103 AC A0A379A9K0.1
#=GS D4GD63_PANAM/5-130 AC D4GD63.1
#=GS A8AR13_CITK8/5-128 AC A8AR13.1
#=GS A0A418YKT7_9GAMM/2-126 AC A0A418YKT7.1
#=GS A0A089Q2Z5_9ENTR/2-125 AC A0A089Q2Z5.1
#=GS A0A4R6TYP9_9GAMM/2-125 AC A0A4R6TYP9.1
#=GS M5DN24_9GAMM/2-134 AC M5DN24.1
#=GS A0A0U5KWQ7_9GAMM/63-188 AC A0A0U5KWQ7.1
#=GS A0A3N9TZ15_9GAMM/7-126 AC A0A3N9TZ15.1
#=GS E9CLI9_9GAMM/2-131 AC E9CLI9.1
#=GS A0A085G3F8_EWIA3/2-124 AC A0A085G3F8.1
#=GS W1N6V1_9GAMM/7-122 AC W1N6V1.1
#=GS B2VJR2_ERWT9/2-127 AC B2VJR2.1
#=GS A0A1C4C471_9ENTR/2-125 AC A0A1C4C471.1
#=GS A0A5J6QGR5_9PSED/2-132 AC A0A5J6QGR5.1
#=GS A0A1I3G6Z9_9GAMM/2-133 AC A0A1I3G6Z9.1
#=GS A0A1X0WFS7_9GAMM/2-125 AC A0A1X0WFS7.1
#=GS A0A0U3K365_9GAMM/2-127 AC A0A0U3K365.1
#=GS A0A1Y0CZ19_9GAMM/3-119 AC A0A1Y0CZ19.1
#=GS A0AA42NNJ4_9PSED/2-129 AC A0AA42NNJ4.1
#=GS A0A5P9H6B7_9GAMM/2-107 AC A0A5P9H6B7.1
#=GS A0A085U6J5_YERRU/2-129 AC A0A085U6J5.1
#=GS D2TLI2_CITRI/2-125 AC D2TLI2.1
#=GS A0A927C2A3_9GAMM/2-126 AC A0A927C2A3.1
#=GS H0J5Q2_9GAMM/6-128 AC H0J5Q2.1
#=GS A0A4Y4F8D7_9GAMM/2-123 AC A0A4Y4F8D7.1
#=GS A1SZI5_PSYIN/4-137 AC A1SZI5.1
#=GS M4U761_9GAMM/3-137 AC M4U761.1
#=GS A0A2N0ZZT3_9GAMM/4-136 AC A0A2N0ZZT3.1
#=GS PANZ_SALTY/2-125 AC Q7CPJ9.1
#=GS A0A317NAY6_9GAMM/10-123 AC A0A317NAY6.1
#=GS S6AJW9_METRE/2-129 AC S6AJW9.1
#=GS A0A2X4SWR0_SALER/2-125 AC A0A2X4SWR0.1
#=GS A0A2N5EI28_9GAMM/2-123 AC A0A2N5EI28.1
#=GS A0A8K0V4L8_9ENTR/2-125 AC A0A8K0V4L8.1
#=GS H5V3I4_ATLHE/19-142 AC H5V3I4.1
#=GS A0A853I0F4_9GAMM/2-127 AC A0A853I0F4.1
#=GS A0A370QTY9_9GAMM/2-131 AC A0A370QTY9.1
#=GS A0A024HNW1_PSEKB/2-127 AC A0A024HNW1.1
#=GS A0A7L5RVG7_9PSED/2-129 AC A0A7L5RVG7.1
#=GS E0SFI3_DICD3/2-131 AC E0SFI3.1
#=GS W7PYR5_9GAMM/6-105 AC W7PYR5.1
#=GS A0A1B2LW03_9GAMM/2-109 AC A0A1B2LW03.1
#=GS K8WH96_9GAMM/2-131 AC K8WH96.1
#=GS A0A366W723_9GAMM/2-137 AC A0A366W723.1
#=GS A0A2P5TIQ0_9GAMM/5-120 AC A0A2P5TIQ0.1
#=GS A0A0H3EQP2_ECO8N/2-125 AC A0A0H3EQP2.1
#=GS A0A233RD93_9GAMM/2-120 AC A0A233RD93.1
#=GS A0A4R3IAT0_9GAMM/4-106 AC A0A4R3IAT0.1
#=GS C4L9Y5_TOLAT/3-125 AC C4L9Y5.1
#=GS A0A484ZBU7_9ENTR/2-125 AC A0A484ZBU7.1
#=GS Q32AS4_SHIDS/2-125 AC Q32AS4.1
#=GS A0A1G8K397_9PSED/2-121 AC A0A1G8K397.1
#=GS I2B469_SHIBC/2-125 AC I2B469.1
#=GS A0A078LHL3_CITKO/2-125 AC A0A078LHL3.1
#=GS A0A2V1H4V0_9GAMM/3-128 AC A0A2V1H4V0.1
#=GS H2G061_OCESG/2-120 AC H2G061.1
#=GS A0A4R3YSZ6_9GAMM/2-130 AC A0A4R3YSZ6.1
#=GS A0A1J7C8V5_9GAMM/2-130 AC A0A1J7C8V5.1
#=GS A0A9X1WW02_9GAMM/2-110 AC A0A9X1WW02.1
#=GS A0A427K5N7_9GAMM/2-124 AC A0A427K5N7.1
#=GS A0A558NGW9_9GAMM/8-137 AC A0A558NGW9.1
#=GS A0A5P9ISK9_9GAMM/2-123 AC A0A5P9ISK9.1
#=GS A0A385Z7A8_9PSED/2-129 AC A0A385Z7A8.1
#=GS A0A8J6UJ96_9GAMM/2-128 AC A0A8J6UJ96.1
#=GS A0A077P1X4_XENBV/2-131 AC A0A077P1X4.1
#=GS A0AA37W2L7_9GAMM/2-125 AC A0AA37W2L7.1
#=GS U3TZP9_9ENTR/2-121 AC U3TZP9.1
#=GS A0A839T2I2_AZOMA/2-127 AC A0A839T2I2.1
#=GS A0A848MMI9_9GAMM/2-125 AC A0A848MMI9.1
#=GS A0A0F7M2S3_9GAMM/2-126 AC A0A0F7M2S3.1
#=GS B7MDU3_ECO45/2-125 AC B7MDU3.1
#=GS A0A0H2VBY9_ECOL6/2-125 AC A0A0H2VBY9.1
#=GS A0A5B8SQM7_9GAMM/3-127 AC A0A5B8SQM7.1
#=GS Q7N005_PHOLL/2-131 AC Q7N005.1
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//
