#=GF ID Pch2_N
#=GF AC PF22107.2
#=GF DE Pch2 N-terminal domain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Andreeva A;0000-0002-0450-0091
#=GF SE ECOD:EF25052
#=GF GA 27.00 27.00;
#=GF TC 30.30 35.50;
#=GF NC 26.60 24.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 81514348 HMM pfamseq
#=GF TP Domain
#=GF CL CL0402
#=GF RC Paper describing PDB structure 4xgu
#=GF RN [1]
#=GF RM 25918846
#=GF RT TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2
#=GF RT conformation switching.
#=GF RA Ye Q, Rosenberg SC, Moeller A, Speir JA, Su TY, Corbett KD;
#=GF RL Elife. 2015; [Epub ahead of print]
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Pch2/TRIP13 belongs to a family of proteins known as AAA-ATPases
#=GF CC and via an adaptor protein binds to the closed form of MAD2.
#=GF CC Pch2/TRIP13 then unfolds a part of the MAD2 protein, converting
#=GF CC MAD2 into the open form. The C.elegans ortholog Pch2 forms a
#=GF CC stable hexamer and its structure consists of a N-terminal domain
#=GF CC and a AAA-ATPase module composed of two subdomains. This entry
#=GF CC represents the N-terminal domain that consists of a
#=GF CC four-stranded beta-sheet and an alpha-helix packed on it. The
#=GF CC structure of this domain shows a clear relationship to the
#=GF CC N-terminal substrate recognition domains of a AAA+ classic
#=GF CC remodeller sub-family that includes NSF, p97, and PEX1.
#=GF SQ 52
#=GS G0P010_CAEBE/4-93 AC G0P010.1
#=GS A0A8S1EWT8_9PELO/31-131 AC A0A8S1EWT8.1
#=GS A0A1I7W3C4_LOALO/1-35 AC A0A1I7W3C4.1
#=GS A8WN70_CAEBR/8-98 AC A8WN70.1
#=GS A0A3P7DYA8_WUCBA/30-117 AC A0A3P7DYA8.1
#=GS A0A914V3N3_9BILA/10-99 AC A0A914V3N3.1
#=GS A0A368GFN2_ANCCA/31-126 AC A0A368GFN2.1
#=GS A0A6G0UXQ2_9BILA/20-106 AC A0A6G0UXQ2.1
#=GS A0A498S9G3_ACAVI/54-130 AC A0A498S9G3.1
#=GS A0A8S1EV04_9PELO/31-131 AC A0A8S1EV04.1
#=GS A0A8J2MBN5_9BILA/34-121 AC A0A8J2MBN5.1
#=GS A0A0B1TEK7_OESDE/2-97 AC A0A0B1TEK7.1
#=GS A0A158T1M8_BRUMA/30-117 AC A0A158T1M8.2
#=GS A0A914DG41_9BILA/28-112 AC A0A914DG41.1
#=GS PCH2_CAEEL/7-100 AC Q09535.1
#=GS PCH2_CAEEL/7-100 DR PDB; 4XGU D; 7-100;
#=GS PCH2_CAEEL/7-100 DR PDB; 4XGU B; 8-100;
#=GS PCH2_CAEEL/7-100 DR PDB; 4XGU E; 8-100;
#=GS PCH2_CAEEL/7-100 DR PDB; 4XGU F; 10-100;
#=GS PCH2_CAEEL/7-100 DR PDB; 4XGU C; 9-100;
#=GS PCH2_CAEEL/7-100 DR PDB; 4XGU A; 7-100;
#=GS A0A0D8XNF1_DICVI/43-138 AC A0A0D8XNF1.1
#=GS A0A915Q348_9BILA/97-172 AC A0A915Q348.1
#=GS A0A914X7M8_9BILA/52-141 AC A0A914X7M8.1
#=GS A0A0B2VNH1_TOXCA/57-144 AC A0A0B2VNH1.1
#=GS A0A182EL50_ONCOC/16-103 AC A0A182EL50.1
#=GS A0A0M3JYI7_ANISI/29-117 AC A0A0M3JYI7.1
#=GS A0A914HRL3_GLORO/44-132 AC A0A914HRL3.1
#=GS A0A915CP65_9BILA/34-102 AC A0A915CP65.1
#=GS A0A3P7ZQB8_9BILA/3-77 AC A0A3P7ZQB8.1
#=GS A0A368GE69_ANCCA/31-126 AC A0A368GE69.1
#=GS A0A914Y1M6_9BILA/20-106 AC A0A914Y1M6.1
#=GS A0A7E4VST0_PANRE/20-107 AC A0A7E4VST0.1
#=GS A0A261C1A3_9PELO/7-100 AC A0A261C1A3.1
#=GS A0A016WR79_9BILA/37-132 AC A0A016WR79.1
#=GS A0A914SHD9_PAREQ/1-51 AC A0A914SHD9.1
#=GS A0A914K125_9BILA/21-107 AC A0A914K125.1
#=GS E3LGT8_CAERE/7-119 AC E3LGT8.1
#=GS A0A915C473_PARUN/38-125 AC A0A915C473.1
#=GS A0A8S1HER5_9PELO/27-126 AC A0A8S1HER5.1
#=GS A0A3P7PTN2_CYLGO/42-163 AC A0A3P7PTN2.1
#=GS A0A3P7JXN5_STRVU/31-119 AC A0A3P7JXN5.1
#=GS A0A914K1A2_9BILA/21-107 AC A0A914K1A2.1
#=GS A0A914X4W3_9BILA/54-143 AC A0A914X4W3.1
#=GS A0A914QNY2_9BILA/20-106 AC A0A914QNY2.1
#=GS A0A0C2D633_9BILA/48-143 AC A0A0C2D633.1
#=GS A0A915HAF0_9BILA/2-105 AC A0A915HAF0.1
#=GS A0A8R1TKL5_ONCVO/34-121 AC A0A8R1TKL5.1
#=GS A0A3P7RZT6_BRUPA/3-77 AC A0A3P7RZT6.1
#=GS A0A0N4W8F9_HAEPC/32-128 AC A0A0N4W8F9.1
#=GS A0A914T4D0_9BILA/20-106 AC A0A914T4D0.1
#=GS A0A2G5UXJ2_9PELO/8-98 AC A0A2G5UXJ2.1
#=GS A0A016WR17_9BILA/31-126 AC A0A016WR17.1
#=GS A0A3P7JJP7_STRVU/10-118 AC A0A3P7JJP7.1
#=GS A0A238BHX4_9BILA/34-121 AC A0A238BHX4.1
#=GS A0A0B1T4R8_OESDE/2-97 AC A0A0B1T4R8.1
#=GS A0A3P6V1F7_LITSI/171-247 AC A0A3P6V1F7.1
#=GS A0A0N5D424_THECL/23-107 AC A0A0N5D424.1
G0P010_CAEBE/4-93 ..........a-TKNLHVEVKLNPKF.......PKSSIQSKIGEIEELIKS..nSTNARNWKPLP....LT......................GEA-.......................ELTELFEKLVIGTCELKDGEQL--VLDDFSIDP..StNLHVYKL.......
A0A8S1EWT8_9PELO/31-131 .........ts--LSLHIEVRLNKKV.......PKSLAMEKLSEIGSFVNS..qLSKSRNWKPID....LQevcd.............pvsdySDKN......................iKLENIIEKVLIGCNQLDDGQSL-SSASEFIPSI..D.NCHIYKL.......
A0A1I7W3C4_LOALO/1-35 ...........---------------.......------------------...-----------....--......................----.......................----MIDCVFIVCSNTPEGESL--TISDTSLTL..A.NVHLYKL.......
A8WN70_CAEBR/8-98 ..........t-LKNLQVEVRLNQKF.......PKSVVQSKIPEFEELIKA..nLEKARNWKPIS....VT......................SESS.......................PITELFEKLVIGSCQLKDGESLSNLLD-FSLDA..S.NIHVYKL.......
A0A3P7DYA8_WUCBA/30-117 ..........s-SPSFHAEIRLNPTT.......ARKDAEKLLPEIHKAILS...VKNVRNGLPIV....LP......................SDN-.......................EFSKIIDDVFIVCSDTPEGEFL--TISDTSLTV..A.NLHLYKL.......
A0A914V3N3_9BILA/10-99 .........ig--STLHVEIRLKRGV.......TKNDGAGAKELVRSYLLD...IGYASNNTSLS....VS......................ERP-.......................ELTNIVEKVIVGQSSLKDGQTV--AFTEASLRDgsA.NYYLYRL.......
A0A368GFN2_ANCCA/31-126 ..........k-TFRPQVEIHLKKGV.......AKSQVEGRISELETFIKL...QKNIRNWIPIV....VNee.................paaGDAK.......................SLTEFIQGIVLGCMNYPDAYPLDAILDKMTLCD..Q.NVHFYKL.......
A0A6G0UXQ2_9BILA/20-106 ..........i-TSTLHLEVRLKKGA.......SKAEVEKHKETILNCINS...VDNVYNWRSFD....LS......................--KH.......................ELFESIDQVLVGCQNTPDGQKI--ESDKIEISS..S.NVHIYS-v......
A0A498S9G3_ACAVI/54-130 .......rifs---------------.......AKKDAEKLLPEIHETLLS...TENVRNGYPVA....LP......................TDK-.......................EFSKMINSIFIVSSDTPEGECL--TISDTSLTL..A.NLHLYKL.......
A0A8S1EV04_9PELO/31-131 .........ts--LSLHIEVRLNKKV.......PKSLAMEKLSEIGSFVNS..qLSKSRNWKPID....LQevcd.............pvsdySDKN......................iKLENIIEKVLIGCNQLDDGQSL-SSASEFIPSI..D.NCHIYKL.......
A0A8J2MBN5_9BILA/34-121 ..........p-NPSFHAEIRLDPTI.......ARKDAEKLLPEIHEALLS...IENVRNGCPVV....LP......................IDK-.......................EFSKMINSVLIVSSDASEGECL--TISDTSLTL..S.NLHLYKL.......
A0A0B1TEK7_OESDE/2-97 ..........k-AFRPQVEVHLKKGI.......AKSQLDGRLPELETFIKQ...QNHIRNWIPIE....VHav.................pfvGDAK.......................PLTEFIQGIVVGCMNYPDACPLDAFLDKMSLCE..Q.NVHFYKL.......
A0A158T1M8_BRUMA/30-117 ..........s-NPSFHAEIRLNPTI.......ARKDAEKLLPEIHKAILS...IKNIRNGHPIA....LP......................SDK-.......................EFSKIIDDVFIVCSDTPEGEFL--TISDTSLTV..A.NLHLYKL.......
A0A914DG41_9BILA/28-112 .........sp--SNVHVEIRLHKGV.......YKSDVEKQRDSIISRILT...-SKIYNWRPFN....VY......................---K.......................ELDSLVSKILIGSAEIPDGELL--NFDGIEAER..I.HTHFYS-v......
PCH2_CAEEL/7-100 ..........t-LKNIHAEIRICQKF.......PKSTVQKRFSEFEELIKA..aSKNARNWKPISsvelFQ......................GDS-.......................SLNELFEKLVIGTCELRDGELFE-NVNDLTINP..S.NIHVYKL.......
#=GR PCH2_CAEEL/7-100 SS ..........------EEEEEE-SSS.......-HHHHHHTHHHHHHHHHH..HHTT-BTTEEEETTTTTS......................S-H-.......................HHHCTEEEEEEE-SSS-TT-B---S--S----T..T.TEEEE--.......
A0A0D8XNF1_DICVI/43-138 ..........k-AFRPHVEVHLKKGV.......SKSQIQGMLMELEILIKK...QKNLFNWIPFV....LQpc.................cdqVDKV.......................VLPDLVNRIVIGCTNFPDASPLEHLLEGLKLNE..F.NVHYYRL.......
A0A915Q348_9BILA/97-172 ........ffs---------------.......SKKDAEKLLPEIYGLLLS...VKNARNGQSVI....LP......................TNN-.......................VCNEIIDNVVIVCSDVPEGDLL--TITNSSLTL..A.NLHLYKL.......
A0A914X7M8_9BILA/52-141 .........ig--STLHVEIRLKRGV.......TKNDGAGAKDLVRSYLLD...IGYASNNTSLS....VS......................ERP-.......................ELTNIVEKVIVGQSSLKDGQTV--TFTETSLRD..G.SA-----kyylyrl
A0A0B2VNH1_TOXCA/57-144 .........li--STVHVEVRIKKGV.......IKWEAEKWRSSIRDTLLS...LDSVLNWRPMP....IS......................NES-.......................SLSKLFESILVGCSAAPDGTTI--KLTDSNLLD..A.NMHIYRL.......
A0A182EL50_ONCOC/16-103 ..........s-NLSFHAEIRLNSTV.......AKKDVEKLLPEIYEALLS...TKNVCNGRSII....LQ......................TDK-.......................EFSKMIDSAVIFCSDIPEGEYL--TVSDTSLTL..A.NVHLYKL.......
A0A0M3JYI7_ANISI/29-117 .........fi--STVHVEVRLKKGV.......SKLEVEKCRPSIRDALLS...SENVLNWRPIS....LS......................DDNG.......................DLSKMIDNILVGCSARPDGSVL--NLRNLTILD..S.NVHIYRM.......
A0A914HRL3_GLORO/44-132 ........ahe---MLDVEIRLTKAN.......CLLDAENCIESLPECIVR..kSEGIRNCRPFF....PK......................-ESE.......................SFPQMVDRLSISCSNVAEGLPLNCHLS--LLKS..A.RYHFY--vv.....
A0A915CP65_9BILA/34-102 ......vsngc---------------.......--------EPTGESALVH...VENIFNWKAFN....VE......................DDS-.......................-LALVADRIVVSCSKQPDGNRL--SLAQEDLKL..S.KVHIY--vv.....
A0A3P7ZQB8_9BILA/3-77 .........fs---------------.......ARKDAEKLLPEIHKAILS...IKNIRNGHPIA....LP......................SDK-.......................EFSKIIDDVFIVCSDTPEGEFL--TISDTSLTV..A.NLHLYKL.......
A0A368GE69_ANCCA/31-126 ..........k-TFRPQVEIHLKKGV.......AKSQVEGRISELEAFIKD...QRNIRNWIPIV....VNee.................paaGDAK.......................SLTEFIQGIVVGCMNYPDAYPLDAILDKMALCD..Q.NVHFYKL.......
A0A914Y1M6_9BILA/20-106 .........it--SSLHLEVRIKKGA.......SKHEIEKLKELIASSVTS...IEDLYNWRSFG....LT......................HP--.......................DLKDIIDQVMIGCSNTPDGQKM--VIESTNIPI..S.NVHVYNV.......
A0A7E4VST0_PANRE/20-107 ..........v-QSTMHLEVRLKKGA.......SKHEIEKCKALISECAKQ..sDADLYNWRSFV....VE......................HP--.......................ELTAVVDQILIGCQNTPDGQKL--LLGDISIPE..N.NVHVYNV.......
A0A261C1A3_9PELO/7-100 ..........p-SQNFQVEIRLNQKF.......PKSTVQTRLPEFEEFIKS..hARNARNWKPIL....VN......................SEESt.....................aSVTELFEKLVIGTCHLKDGDKLNNLLDEFSINP..S.NIHVYKL.......
A0A016WR79_9BILA/37-132 ..........k-TFRPQVEIHLKKGV.......AKSQVEGRISELEAFIKV...QRNIRNWIPIV....VNee.................patGDSK.......................SLTEFIQGIVVGCMNYPDAYPLDAILDKMTLCD..Q.NVHFYKL.......
A0A914SHD9_PAREQ/1-51 ..........m---------------.......---DAEKYRSLVRDALLS...LENVVNWRPVS....LT......................DEH-.......................NLSTLVENILVGCSASPEG--------------..-.-------.......
A0A914K125_9BILA/21-107 .........vt--PNLHLEVRLKKGI.......SKIQIENCKEAIAKSINC...MENLYNWRSFA....LM......................-DH-.......................ELADSIDQILVGCYNTPDGQKI--EFGKIDIPV..S.NVHVYNV.......
E3LGT8_CAERE/7-119 ..........p-SQNFQVEIRLNQKF.......PKSTVQTRLPEFEEFIKS..hATNARNWKPIV....VK......................SEESpasglwlchn..ffiknltimffPVTELFEKLVIGTCHLKDGDKLSNLLDEFSINP..S.NIHVYKL.......
A0A915C473_PARUN/38-125 .........li--SSTHVEVRLKRGV.......SKMDAEKYRSLVRDALLS...LENVVNWRPVS....LT......................DEH-.......................NLSTLVENILVGCSASPEGTSL--TLTDSSISD..A.NVHFYRM.......
A0A8S1HER5_9PELO/27-126 .........qm--PKIQLELRLNRKI.......AKSVAEGRLEEIGKMLRS...TNKVLNWKSFL...pFKasr................dgdS--Ees...................elEIEDLFEEGMLGTTQMTDGAPLTEFLHDFSATS..S.NVHFYKL.......
A0A3P7PTN2_CYLGO/42-163 ..........r-KFRPQVEVHLKKGIilltlysAKSQLEGKLSELEALIKK...QKSLRNWIPAQ....MQdlvvsdelrclagepfraisirK--Knr...................qiSIAELIQGIMVGCMNYSDAYPLNDILDKISLCD..Q.NVHFYKL.......
A0A3P7JXN5_STRVU/31-119 ..........k-TFRPQVEVHLKKGI.......AKSQLEEKLPELETLIKQ...QRNIRNWIPAE....LVev.................emaDRSK.......................SLADLIQGIVVGCMNYPDAYPLDDILDKV----..-.-------rpalv..
A0A914K1A2_9BILA/21-107 .........vt--PNLHLEVRLKKGI.......SKIQIENCKEAIAKSINC...MENLYNWRSFA....LM......................-DH-.......................ELADSIDQILVGCYNTPDGQKI--EFGKIDIPV..S.NVHVYNV.......
A0A914X4W3_9BILA/54-143 .........ig--STLHVEIRLKRGV.......TKNDGAGAKDLVRSYLLD...IGYASNNTSLS....VS......................ERP-.......................ELTNIVEKVIVGQSSLKDGQTV--TFTETSLRD..G.SA-----kyylyrl
A0A914QNY2_9BILA/20-106 .........it--SSLHLEVRVKKGA.......SKHEIEKLKDLIASSVTS...IDDLYNWRSFG....LT......................HP--.......................DLKDVIDQAMIGCSNTPDGQRM--LMESKNIPV..S.NVHVYNV.......
A0A0C2D633_9BILA/48-143 ..........k-TFRPQVEIHLKKGV.......AKSQVDGRISELEAFIKV...QRNIRNWIPIV....VNee.................patGDSK.......................SLTEFIQGIVVGCMNYPDAYPLDAILDKMTLCD..Q.NVHFYKL.......
A0A915HAF0_9BILA/2-105 .......stei----VSVAVRLKRGI.......ARSSIESRLEELSGLIQEeilRGKVYNWRAFM....IS......................QQEAdfeqviv.........enlqvlpAFSTLISAIVFGSLTANDGEML-KFTE--KLDH..Q.LFHIY--c......
A0A8R1TKL5_ONCVO/34-121 ..........s-NLSFHAEIRLNSTV.......AKKDVEKLLPEIYEALLS...TKNVCNGRSII....LQ......................TDK-.......................EFSKMIDSAVIFCSDIPEGEYL--TVSATSLTL..A.NVHLYKL.......
A0A3P7RZT6_BRUPA/3-77 .........fs---------------.......ARKDAEKLLPEIHKAILS...IKNIRNGHPIA....LP......................SDK-.......................EFSKIIDDVFIVCSDTPEGEFL--TISDTSLTV..A.NLHLYKL.......
A0A0N4W8F9_HAEPC/32-128 ..........r-LFKPHVEVQLRKGV.......AKSQIEKRIPELESFIRK...QKNLRNWVPST....VEpsd................aasGDND.......................SLANLIHGIVIGCTNFPDACPLNSLLEDVKLDE..H.NVHFYRL.......
A0A914T4D0_9BILA/20-106 .........it--SSLHLEVRVKKGA.......SKHEIEKLKDLIASSVTS...IDDLYNWRSFG....LT......................HP--.......................DLKDVIDQAMIGCSNTPDGQRM--LMESKNIPA..S.NVHVYNV.......
A0A2G5UXJ2_9PELO/8-98 ..........p-LQNLQVEVRLNQKF.......PKSAVQSKIPELEELIKA..nLEKARNWKPIN....VT......................SESS.......................PITELFEKLVIGSCQLKDGESLSNLLD-FSLDA..S.NIHVYKL.......
A0A016WR17_9BILA/31-126 ..........k-TFRPQVEIHLKKGV.......AKSQVEGRISELEAFIKV...QRNIRNWIPIV....VNee.................patGDSK.......................SLTEFIQGIVVGCMNYPDAYPLDAILDKMTLCD..Q.NVHFYKL.......
A0A3P7JJP7_STRVU/10-118 ........lvs------------PKN.......AKSQLEEKLPELETLIKQ...QRNIRNWIPAQ....LVev..................emADRSkslagrfvpfgilcfagiyllncFFLDLIQGIVVGCMNYPDAYPLDDILDKVTLCD..K.NVHFYKL.......
A0A238BHX4_9BILA/34-121 ..........s-NLSFHAEIRLNPTV.......AKKDVEKLLPEIYEALLS...TKNVPNGRSII....LQ......................SDK-.......................EFSKMIDSAVIFCSYIPEGEYL--TISDASLTL..A.NVHLYKL.......
A0A0B1T4R8_OESDE/2-97 ..........k-AFRPQVEVHLKKGI.......AKSQLDGRLPELETFIKQ...QNHIRNWIPIE....VHav.................pfvGDAK.......................PLTEFIQGIVVGCMNYPDACPLDAILDKMSLCE..Q.NVHFYKL.......
A0A3P6V1F7_LITSI/171-247 .......wrnr---------------.......AKKDAEKLLPEIHEALLS...IENVRNGRPVV....LP......................TDK-.......................EFSKIISSVFIVSSDAPEGEYL--AISKTSLTL..S.NLHLYKL.......
A0A0N5D424_THECL/23-107 spflslqyndc--------------S.......LKKEAQKFIPEIHATLLS...MKGVRNGYPIV....MP......................TNL-.......................EWSEVVEKIVVLCTNTPEGEFV--TLSDSSLVI..S.NVHMYKL.......
#=GC SS_cons ..........------EEEEEE-SSS.......-HHHHHHTHHHHHHHHHH..HHTT-BTTEEEETTTTTS......................S-H-.......................HHHCTEEEEEEE-SSS-TT-B---S--S----T..T.TEEEE--.......
#=GC seq_cons ..........p...p.plEl+Lppsh.......uKppsEphlsElcphlhs...hcslpNWpPls....ls......................s-p........................ploclI-plllGCsshPDGp.L..hlschoLs...u.NlHlY+L.......
//
