GenomeNet

Database: Pfam
Entry: Pep_M12B_propep
LinkDB: Pep_M12B_propep
Original site: Pep_M12B_propep 
#=GF ID   Pep_M12B_propep
#=GF AC   PF01562.22
#=GF DE   Reprolysin family propeptide
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_117 (release 4.0)
#=GF GA   22.70 22.70;
#=GF TC   22.70 22.70;
#=GF NC   22.60 22.60;
#=GF BM   hmmbuild --amino HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RC   See pages 196-198
#=GF RN   [1]
#=GF RM   7674922
#=GF RT   Evolutionary families of metallopeptidases. 
#=GF RA   Rawlings ND, Barrett AJ; 
#=GF RL   Meth Enzymol 1995;248:183-228.
#=GF DR   INTERPRO; IPR002870;
#=GF DR   MEROPS; M12;
#=GF DR   SCOP; 1fvl; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This region is the propeptide for members of peptidase family
#=GF CC   M12B.  The propeptide contains a sequence motif similar to the
#=GF CC   "cysteine switch" of the matrixins. This motif is found at the C
#=GF CC   terminus of the alignment but is not well aligned.
#=GF SQ   16227
#=GS A0A5N4CKB5_CAMDR/81-221     AC A0A5N4CKB5.1
#=GS A0A3Q4I046_NEOBR/41-186     AC A0A3Q4I046.1
#=GS A0A2Y9P673_DELLE/67-208     AC A0A2Y9P673.1
#=GS A0A6J3ED91_AYTFU/31-155     AC A0A6J3ED91.1
#=GS A0A3P8WHZ1_CYNSE/39-187     AC A0A3P8WHZ1.1
#=GS A0A452GAL8_CAPHI/41-186     AC A0A452GAL8.1
#=GS A0A3P9ANJ0_ESOLU/57-198     AC A0A3P9ANJ0.1
#=GS A0A663LXW7_ATHCN/63-192     AC A0A663LXW7.1
#=GS A0A4S2KCG7_9HYME/22-158     AC A0A4S2KCG7.1
#=GS A0A7E6DU99_9CHIR/121-292    AC A0A7E6DU99.1
#=GS A0A3Q2FSS4_CYPVA/16-144     AC A0A3Q2FSS4.1
#=GS A0A669QJ82_PHACC/45-192     AC A0A669QJ82.1
#=GS A0A668SQ25_OREAU/5-92       AC A0A668SQ25.1
#=GS A0A3P8UJB1_CYNSE/38-167     AC A0A3P8UJB1.1
#=GS A0A2I0UGW0_LIMLA/54-123     AC A0A2I0UGW0.1
#=GS A0A6P6E0E3_OCTDE/36-181     AC A0A6P6E0E3.1
#=GS A0A5E4D1R6_MARMO/1-64       AC A0A5E4D1R6.1
#=GS A0A3Q3LVA8_9TELE/51-195     AC A0A3Q3LVA8.2
#=GS A0A452E2H3_CAPHI/129-250    AC A0A452E2H3.1
#=GS A0A4W3H112_CALMI/3-129      AC A0A4W3H112.1
#=GS A0A5G2QFB9_PIG/13-123       AC A0A5G2QFB9.1
#=GS W5NVP8_SHEEP/1-112          AC W5NVP8.1
#=GS A0A674CKY4_SALTR/66-204     AC A0A674CKY4.1
#=GS A0A2R8ZWA8_PANPA/14-141     AC A0A2R8ZWA8.1
#=GS A0A672U6F6_STRHB/96-221     AC A0A672U6F6.1
#=GS A0A7N6AS51_ANATE/48-192     AC A0A7N6AS51.1
#=GS A0A6P3J334_BISBI/41-186     AC A0A6P3J334.1
#=GS A0A444U725_ACIRT/72-157     AC A0A444U725.1
#=GS A0A6P7J3X0_9TELE/45-178     AC A0A6P7J3X0.1
#=GS A0A667WKB6_9TELE/41-184     AC A0A667WKB6.1
#=GS A0A2U3XSY8_LEPWE/40-159     AC A0A2U3XSY8.1
#=GS A0A6P7KT56_BETSP/53-192     AC A0A6P7KT56.1
#=GS A0A6I9LC81_PERMB/30-153     AC A0A6I9LC81.1
#=GS A0A6I8QIW1_XENTR/89-229     AC A0A6I8QIW1.2
#=GS A0A341BP44_NEOAA/1-96       AC A0A341BP44.1
#=GS A0A2R9A9H5_PANPA/20-94      AC A0A2R9A9H5.1
#=GS A0A668SNS4_OREAU/1-90       AC A0A668SNS4.1
#=GS A0A2P8YZ70_BLAGE/32-169     AC A0A2P8YZ70.1
#=GS A0A0D9RUJ7_CHLSB/1-96       AC A0A0D9RUJ7.1
#=GS A0A6J3R1P8_TURTR/53-195     AC A0A6J3R1P8.1
#=GS A0A6G0HMV3_LARCR/17-170     AC A0A6G0HMV3.1
#=GS A0A6P5LLW7_PHACI/17-161     AC A0A6P5LLW7.1
#=GS A0A6P6BZZ3_PTEVA/40-180     AC A0A6P6BZZ3.1
#=GS A0A091Q528_LEPDC/3-136      AC A0A091Q528.1
#=GS A0A2K5L5P3_CERAT/55-210     AC A0A2K5L5P3.1
#=GS A0A6J2MUN1_9CHIR/47-186     AC A0A6J2MUN1.1
#=GS A0A151MEA8_ALLMI/19-144     AC A0A151MEA8.1
#=GS A0A673ZJJ0_SALTR/21-165     AC A0A673ZJJ0.1
#=GS A0A6P8U9C6_GYMAC/11-146     AC A0A6P8U9C6.1
#=GS A0A6P5M3R3_PHACI/116-255    AC A0A6P5M3R3.1
#=GS A0A667XK77_9TELE/19-153     AC A0A667XK77.1
#=GS A0A0R3WZ11_HYDTA/1-59       AC A0A0R3WZ11.1
#=GS A0A0V0ZLX5_9BILA/2-115      AC A0A0V0ZLX5.1
#=GS A0A2S4N9Z8_9FLAO/46-178     AC A0A2S4N9Z8.1
#=GS H3B4Z2_LATCH/53-169         AC H3B4Z2.1
#=GS V8NZD2_OPHHA/31-170         AC V8NZD2.1
#=GS A0A2K5EHA8_AOTNA/6-139      AC A0A2K5EHA8.1
#=GS A0A6I9IFW5_VICPA/25-153     AC A0A6I9IFW5.1
#=GS L8HUJ8_9CETA/70-191         AC L8HUJ8.1
#=GS A0A093HCS1_STRCA/20-167     AC A0A093HCS1.1
#=GS A0A1D2NCY5_ORCCI/47-211     AC A0A1D2NCY5.1
#=GS S9Y846_CAMFR/28-163         AC S9Y846.1
#=GS A0A673WH44_SALTR/19-177     AC A0A673WH44.1
#=GS G1ND70_MELGA/1-141          AC G1ND70.2
#=GS A0A287DEC8_ICTTR/26-153     AC A0A287DEC8.1
#=GS Q5JRP2_HUMAN/40-165         AC Q5JRP2.1
#=GS A0A6J3D3V4_AYTFU/24-146     AC A0A6J3D3V4.1
#=GS A0A6P3FLP1_OCTDE/32-167     AC A0A6P3FLP1.1
#=GS A0A556THT0_BAGYA/41-181     AC A0A556THT0.1
#=GS A0A493TAE4_ANAPP/50-197     AC A0A493TAE4.1
#=GS A0A2K6K278_RHIBE/23-150     AC A0A2K6K278.1
#=GS A0A6G1AG80_CROCR/13-182     AC A0A6G1AG80.1
#=GS A0A5N5KD40_PANHP/15-151     AC A0A5N5KD40.1
#=GS F6SJB8_CALJA/30-158         AC F6SJB8.2
#=GS V3ZLC7_LOTGI/37-169         AC V3ZLC7.1
#=GS A2RSG8_MOUSE/34-159         AC A2RSG8.1
#=GS A0A6J2X962_SITOR/94-244     AC A0A6J2X962.1
#=GS A0A315VJZ6_GAMAF/207-253    AC A0A315VJZ6.1
#=GS A0A673XM48_SALTR/3-35       AC A0A673XM48.1
#=GS A0A6P6E010_OCTDE/36-181     AC A0A6P6E010.1
#=GS A0A6I9PI78_9TELE/44-201     AC A0A6I9PI78.1
#=GS A0A3Q7VIE0_URSAR/21-188     AC A0A3Q7VIE0.1
#=GS G1KNW2_ANOCA/44-198         AC G1KNW2.1
#=GS A0A091H101_9AVES/11-153     AC A0A091H101.1
#=GS A0A0K6G5C0_9AGAM/31-135     AC A0A0K6G5C0.1
#=GS A0A0V0UVJ0_9BILA/57-201     AC A0A0V0UVJ0.1
#=GS A0A087TGI8_STEMI/25-161     AC A0A087TGI8.1
#=GS A0A2Y9H128_NEOSC/34-188     AC A0A2Y9H128.1
#=GS A0A663E798_AQUCH/27-156     AC A0A663E798.1
#=GS A0A384AWE3_BALAS/139-283    AC A0A384AWE3.1
#=GS A0A452FAF5_CAPHI/34-163     AC A0A452FAF5.1
#=GS A0A0V0TXA4_9BILA/36-171     AC A0A0V0TXA4.1
#=GS A0A2I3M499_PAPAN/38-188     AC A0A2I3M499.1
#=GS A0A452CPR3_BALAS/34-159     AC A0A452CPR3.1
#=GS A0A2R8MX54_CALJA/35-162     AC A0A2R8MX54.1
#=GS A0A267F7W0_9PLAT/55-186     AC A0A267F7W0.1
#=GS A0A2K6U5A2_SAIBB/25-168     AC A0A2K6U5A2.1
#=GS A0A6I9J3S0_CHRAS/45-188     AC A0A6I9J3S0.1
#=GS B4JYM1_DROGR/44-181         AC B4JYM1.1
#=GS S9XQP7_CAMFR/42-160         AC S9XQP7.1
#=GS A0A7M7MUU7_APIME/88-225     AC A0A7M7MUU7.1
#=GS A0A4W6D152_LATCA/27-200     AC A0A4W6D152.1
#=GS A0A2Y9JEB8_ENHLU/46-186     AC A0A2Y9JEB8.1
#=GS H3DA49_TETNG/1-56           AC H3DA49.1
#=GS A0A5N3W130_MUNRE/50-183     AC A0A5N3W130.1
#=GS A0A674MQ32_TAKRU/7-106      AC A0A674MQ32.1
#=GS A0A369RUH1_9METZ/71-222     AC A0A369RUH1.1
#=GS A0A7N9DA05_MACFA/56-184     AC A0A7N9DA05.1
#=GS A0A485P5C0_LYNPA/19-157     AC A0A485P5C0.1
#=GS A0A671RLJ4_9TELE/35-192     AC A0A671RLJ4.1
#=GS F1PGL0_CANLF/43-176         AC F1PGL0.2
#=GS A0A673GNX1_9TELE/28-171     AC A0A673GNX1.1
#=GS A0A384CZW4_URSMA/79-207     AC A0A384CZW4.1
#=GS A0A6I9MSF8_9TELE/40-166     AC A0A6I9MSF8.1
#=GS A0A674B8D6_SALTR/25-170     AC A0A674B8D6.1
#=GS A0A7F8QBH5_LEPWE/40-180     AC A0A7F8QBH5.1
#=GS A0A7F5RP28_AGRPL/25-160     AC A0A7F5RP28.1
#=GS A0A6F9A8K3_9TELE/50-160     AC A0A6F9A8K3.1
#=GS A0A671Q3T8_9TELE/30-140     AC A0A671Q3T8.1
#=GS A0A663LLS4_ATHCN/2-106      AC A0A663LLS4.1
#=GS A0A3Q2CFB5_CYPVA/2-63       AC A0A3Q2CFB5.1
#=GS A0A2K5RL55_CEBIM/139-279    AC A0A2K5RL55.1
#=GS A0A3R7MLV1_PENVA/106-183    AC A0A3R7MLV1.1
#=GS T1K9Y1_TETUR/31-160         AC T1K9Y1.1
#=GS Q400M8_DROME/40-188         AC Q400M8.2
#=GS A0A665X6F6_ECHNA/27-189     AC A0A665X6F6.1
#=GS A0A2K5CU39_AOTNA/27-156     AC A0A2K5CU39.1
#=GS G1QC05_MYOLU/31-161         AC G1QC05.1
#=GS L5KCQ7_PTEAL/18-93          AC L5KCQ7.1
#=GS A0A4W5LMI6_9TELE/25-154     AC A0A4W5LMI6.1
#=GS A0A2R9AGK0_PANPA/14-141     AC A0A2R9AGK0.1
#=GS H3CD70_TETNG/20-155         AC H3CD70.1
#=GS A0A672ZW78_9TELE/26-171     AC A0A672ZW78.1
#=GS A0A673I7J2_9TELE/28-160     AC A0A673I7J2.1
#=GS A0A0J7L3H7_LASNI/12-142     AC A0A0J7L3H7.1
#=GS A0A7N4UYU6_SARHA/42-103     AC A0A7N4UYU6.1
#=GS A0A6J2N2G8_9CHIR/110-230    AC A0A6J2N2G8.2
#=GS A0A182Y5H1_ANOST/72-193     AC A0A182Y5H1.1
#=GS A0A2B4RGB5_STYPI/268-405    AC A0A2B4RGB5.1
#=GS A0A5F8MPY1_MOUSE/56-211     AC A0A5F8MPY1.1
#=GS A0A6P7Y6J4_9AMPH/24-150     AC A0A6P7Y6J4.1
#=GS A0A286XGU2_CAVPO/42-181     AC A0A286XGU2.1
#=GS H2Y604_CIOSA/3-139          AC H2Y604.1
#=GS A0A4W2DY66_BOBOX/41-128     AC A0A4W2DY66.1
#=GS A0A4W3KKF5_CALMI/21-150     AC A0A4W3KKF5.1
#=GS A0A401NH58_SCYTO/3-125      AC A0A401NH58.1
#=GS A0A672RJ59_SINGR/26-183     AC A0A672RJ59.1
#=GS A0A6A4WGL0_AMPAM/30-153     AC A0A6A4WGL0.1
#=GS F7CZH8_HORSE/14-141         AC F7CZH8.2
#=GS A0A4W3HCS1_CALMI/25-167     AC A0A4W3HCS1.1
#=GS A0A2I4BR66_9TELE/15-149     AC A0A2I4BR66.1
#=GS A0A6P6H7U1_PUMCO/49-179     AC A0A6P6H7U1.1
#=GS A0A6P9B3V3_PANGU/80-274     AC A0A6P9B3V3.1
#=GS A0A673T965_SURSU/33-188     AC A0A673T965.1
#=GS A0A7N5ZTY3_ANATE/34-178     AC A0A7N5ZTY3.1
#=GS A0A674CNG8_SALTR/34-106     AC A0A674CNG8.1
#=GS A0A6P8YXS9_THRPL/96-244     AC A0A6P8YXS9.1
#=GS A0A5F4D3F6_CANLF/12-141     AC A0A5F4D3F6.1
#=GS A0A151WUP5_9HYME/15-152     AC A0A151WUP5.1
#=GS A0A6I9ZU61_ACIJB/19-141     AC A0A6I9ZU61.1
#=GS A0A6Q2ZLH3_ESOLU/66-211     AC A0A6Q2ZLH3.1
#=GS A0A674J6S7_TERCA/7-130      AC A0A674J6S7.1
#=GS A0A6P9DKK0_PANGU/23-142     AC A0A6P9DKK0.1
#=GS E0VJV8_PEDHC/8-150          AC E0VJV8.1
#=GS A0A484CKE4_PERFV/44-168     AC A0A484CKE4.1
#=GS A0A0V1BE18_TRISP/63-194     AC A0A0V1BE18.1
#=GS A0A4W2DWS0_BOBOX/12-141     AC A0A4W2DWS0.1
#=GS A0A226P6L6_COLVI/665-813    AC A0A226P6L6.1
#=GS A0A803K8I8_XENTR/20-164     AC A0A803K8I8.1
#=GS A0A452I6G3_9SAUR/1-80       AC A0A452I6G3.1
#=GS A0A3Q3NIR8_9TELE/25-163     AC A0A3Q3NIR8.1
#=GS A0A6P5LV85_PHACI/38-177     AC A0A6P5LV85.1
#=GS A0A667YKH4_9TELE/5-141      AC A0A667YKH4.1
#=GS A0A6P8HS31_ACTTE/43-155     AC A0A6P8HS31.1
#=GS A0A4Z2CQ16_SCHJA/4-121      AC A0A4Z2CQ16.1
#=GS A0A2K5CYC5_AOTNA/24-157     AC A0A2K5CYC5.1
#=GS G3VAH7_SARHA/42-167         AC G3VAH7.2
#=GS A0A1S3LDJ2_SALSA/44-201     AC A0A1S3LDJ2.1
#=GS A0A4W4G1M0_ELEEL/8-123      AC A0A4W4G1M0.1
#=GS A0A6P6PT04_CARAU/54-197     AC A0A6P6PT04.1
#=GS F4X616_ACREC/44-183         AC F4X616.1
#=GS A0A3M7RWB4_BRAPC/27-151     AC A0A3M7RWB4.1
#=GS A0A668VTY3_OREAU/27-173     AC A0A668VTY3.1
#=GS A0A1U7RHI9_MESAU/36-167     AC A0A1U7RHI9.1
#=GS A0A4W4GMF8_ELEEL/25-147     AC A0A4W4GMF8.1
#=GS G3WJ68_SARHA/29-161         AC G3WJ68.2
#=GS A0A6J2MX11_9CHIR/26-148     AC A0A6J2MX11.1
#=GS A0A5C6NSE9_9TELE/51-210     AC A0A5C6NSE9.1
#=GS A0A091SV43_PELCR/3-136      AC A0A091SV43.1
#=GS A0A3Q7SGA2_VULVU/19-157     AC A0A3Q7SGA2.1
#=GS A0A2Y9DHD1_TRIMA/43-191     AC A0A2Y9DHD1.1
#=GS V8N0F2_OPHHA/4-128          AC V8N0F2.1
#=GS A0A6I8NB70_ORNAN/88-230     AC A0A6I8NB70.1
#=GS A0A669EG79_ORENI/36-173     AC A0A669EG79.1
#=GS A0A452E8F4_CAPHI/17-126     AC A0A452E8F4.1
#=GS M3XDF4_FELCA/19-141         AC M3XDF4.1
#=GS G1NR58_MELGA/70-192         AC G1NR58.1
#=GS A0A3L8S0Z3_CHLGU/84-208     AC A0A3L8S0Z3.1
#=GS A0A672LN32_SINGR/32-177     AC A0A672LN32.1
#=GS A0A2Y9KBC1_ENHLU/24-157     AC A0A2Y9KBC1.1
#=GS A0A3Q2DP76_CYPVA/39-204     AC A0A3Q2DP76.1
#=GS A0A4C1T6Y2_EUMVA/131-208    AC A0A4C1T6Y2.1
#=GS A0A667WYU5_9TELE/41-184     AC A0A667WYU5.1
#=GS A0A556TIK9_BAGYA/25-99      AC A0A556TIK9.1
#=GS A0A1L8GI02_XENLA/1-131      AC A0A1L8GI02.1
#=GS A0A4W6FYV3_LATCA/35-122     AC A0A4W6FYV3.1
#=GS A0A6J3IFP8_SAPAP/34-151     AC A0A6J3IFP8.1
#=GS A0A1W4WQD5_AGRPL/18-158     AC A0A1W4WQD5.1
#=GS A0A2Y9K358_ENHLU/27-156     AC A0A2Y9K358.1
#=GS A0A6I9KRJ9_CHRAS/22-159     AC A0A6I9KRJ9.1
#=GS A0A2K6JVF8_RHIBE/38-188     AC A0A2K6JVF8.1
#=GS A0A556U8Y5_BAGYA/81-233     AC A0A556U8Y5.1
#=GS E7FEN5_DANRE/41-197         AC E7FEN5.2
#=GS F2UCI9_SALR5/86-226         AC F2UCI9.1
#=GS G0PKK9_CAEBE/29-164         AC G0PKK9.1
#=GS A0A2K5XPE0_MANLE/28-155     AC A0A2K5XPE0.1
#=GS A0A158NXT6_ATTCE/45-189     AC A0A158NXT6.1
#=GS A0A6P5BKX0_BOSIN/30-150     AC A0A6P5BKX0.1
#=GS A0A493TPV7_ANAPP/51-179     AC A0A493TPV7.1
#=GS A0A674PEN8_TAKRU/39-171     AC A0A674PEN8.1
#=GS A0A2K6DC48_MACNE/15-137     AC A0A2K6DC48.1
#=GS L8IX70_9CETA/9-138          AC L8IX70.1
#=GS A0A1A6H4D3_NEOLE/14-152     AC A0A1A6H4D3.1
#=GS A0A672RYU9_SINGR/6-121      AC A0A672RYU9.1
#=GS G3X800_BOVIN/49-167         AC G3X800.2
#=GS H3DNF0_TETNG/5-131          AC H3DNF0.1
#=GS G3RE41_GORGO/30-158         AC G3RE41.2
#=GS A0A2Y9I964_NEOSC/43-201     AC A0A2Y9I964.1
#=GS A0A672I385_SALFA/20-136     AC A0A672I385.1
#=GS A0A3M0KZ91_HIRRU/1041-1177  AC A0A3M0KZ91.1
#=GS A0A674GQY5_TAEGU/54-196     AC A0A674GQY5.1
#=GS A0A6G1QTN3_9TELE/21-150     AC A0A6G1QTN3.1
#=GS A0A6P9AM21_PANGU/49-186     AC A0A6P9AM21.1
#=GS M4AL57_XIPMA/37-198         AC M4AL57.1
#=GS A0A3Q4GWA7_NEOBR/21-143     AC A0A3Q4GWA7.1
#=GS A0A665W7Y1_ECHNA/23-153     AC A0A665W7Y1.1
#=GS A0A6J2PJ24_COTGO/45-191     AC A0A6J2PJ24.1
#=GS A0A674P6U7_TAKRU/6-50       AC A0A674P6U7.1
#=GS A0A2Y9N1R6_DELLE/110-249    AC A0A2Y9N1R6.1
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