#=GF ID   Peptidase_C37
#=GF AC   PF05416.19
#=GF DE   Southampton virus-type processing peptidase
#=GF AU   Studholme DJ;0000-0002-3010-6637
#=GF SE   Manual
#=GF GA   20.20 20.20;
#=GF TC   20.20 20.60;
#=GF NC   20.10 20.00;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 90746521 --cpu 8 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0124
#=GF RN   [1]
#=GF RM   12021327
#=GF RT   Identification of active-site amino acid residues in the Chiba
#=GF RT   virus 3C-like protease. 
#=GF RA   Someya Y, Takeda N, Miyamura T; 
#=GF RL   J Virol 2002;76:5949-5958.
#=GF DR   INTERPRO; IPR001665;
#=GF DR   MEROPS; C37;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Corresponds to Merops family C37. Norwalk-like viruses (NLVs),
#=GF CC   including the Southampton virus, cause acute non-bacterial
#=GF CC   gastroenteritis in humans. The NLV genome encodes three open
#=GF CC   reading frames (ORFs). ORF1 encodes a polyprotein, which is
#=GF CC   processed by the viral protease into six proteins.
#=GF SQ   6
#=GS POLG_SVSAP/923-1020      AC Q672I1.1
#=GS POLG_NVN68/706-1269      AC Q83883.1
#=GS A0A8X7SWX1_9BASI/35-222  AC A0A8X7SWX1.1
#=GS Q38QJ4_9VIRU/2571-2611   AC Q38QJ4.1
#=GS A0A0E0ATU9_9ORYZ/23-118  AC A0A0E0ATU9.1
#=GS A0A9P9SY90_9PLEO/62-171  AC A0A9P9SY90.1
POLG_SVSAP/923-1020                 .......................................................saaniaylm-----------------------------------.----------------------------------------------------------------------------------------------------...--------------------------------------------------..-----.....................-------------------------.----..------TRGSRTEE.AKGKTKHGRGMR..HGHRAGVSLSDDEYDEWRDLMRDWRRDMSVNDFL.MLRER--SALGVDDEDEARYRAW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------leiramrmaggayt
POLG_NVN68/706-1269                 ................................................................KPDFSHLKMELAPQGGFDNQGNTPFGKGVMKPTTI.NRLLIQAVALTMERQDEFQLQGPTYDFDTDRVAAFTRMARANGLGLISMASLGKKLRSVTTIEGLKNALSGYKISKCSIQWQSRVYIIESDGA-SVQIKEdkqALTPLQQTINTASLAITRLKAARAVAYASCFQSAITTILQMAGSALVINR..AVKRMfgtrtaamalegpgkehncrvHKAKEAGKGPIGHDDMVERFGLCET.EEEEseDQIQMVPSDAVPEGkNKGKTKKGRGRKnnYNAFSRRGLSDEEYEEYKKIREEKNGNYSIQEYL.EDRQRYEEELAEVQAGGDGGIGETEMEIRHRVFYKSKSKKHQQEQRRQLGLVTGSDIRKRKPIDWTPPKNEWADDDREVDYNEKINFEAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIAIHQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAVRMGAIASMRIQGRLVHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDWVVCGVHAAATKSGNTVVC..............
#=GR POLG_NVN68/706-1269      AS    ..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................*.......................*....................................................................................*............................................
A0A8X7SWX1_9BASI/35-222             avttdrsvlkkarrhwalflhpdknpdpqaveamkllnqafdvlmtlppgqlwraphqteptka-----------------------------------.----------------------------------------------------------------------------------------------------...--------------------------------------------------..-----.....................-------RPTGGASQKQQGKAKHNDpQQAK..ERQRQKDQQRQKDQ.EQRQDQKQRQQK..QQKQKQKQLQEEEHEAYLRQQE-RQRRCQQEDWMrQERARFEWHLLERQRKEAADCEQRRRTI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------stitktmvatvla.
Q38QJ4_9VIRU/2571-2611              ...........................................................tdtvf-----------------------------------.----------------------------------------------------------------------------------------------------...--------------------------------------------------..-----.....................-------------------------.----..--------------.------------..----------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFSGDCGLPYIYKHGSEYKMIGIHAMATTSP-----gsyvs.........
A0A0E0ATU9_9ORYZ/23-118             .........................................................kavvshv-----------NAQGPHDFQKENAVLKGQMESLTReNTILKRAFAIQHERQKDYDAKNQELQDEKQRIAEFQEQVRNLELNNYRLS--------------------------------------------------...--------------------------------------------------..-----.....................-------------------------.----..--------------.------------..----------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------mllrqaqqgssipg
A0A9P9SY90_9PLEO/62-171             .................................................vnpdlederrnlvtp-----------------------------------.----------------------------------------------------------------------------------------------------...--------------ALKTI--ARI-TLWGIIKSAISTGIVLGITAWAVWKlfIVKRW.....................-VEDVEYEGNVDADEALENLGEEEK.EKEK..EKKDEEEEKSEKAA.EEEKKKKGKGKK..----------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------k.............
#=GC seq_cons                       .........................................................tt.sshh................................................................................................................................................................................................................................................................ptt..tt.tptppp+t+t.+......................................................................................................................................................................................................................................................................................................h.hht.........
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