GenomeNet

Database: Pfam
Entry: Peptidase_S32
LinkDB: Peptidase_S32
Original site: Peptidase_S32 
#=GF ID   Peptidase_S32
#=GF AC   PF05579.16
#=GF DE   Equine arteritis virus serine endopeptidase S32
#=GF AU   Studholme DJ;0000-0002-3010-6637
#=GF SE   Merops
#=GF GA   24.70 24.70;
#=GF TC   24.70 24.90;
#=GF NC   24.60 24.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0124
#=GF RN   [1]
#=GF RM   10725411
#=GF RT   Virus-encoded proteinases and proteolytic processing in the
#=GF RT   Nidovirales. 
#=GF RA   Ziebuhr J, Snijder EJ, Gorbalenya AE; 
#=GF RL   J Gen Virol 2000;81:853-879.
#=GF RN   [2]
#=GF RM   19646449
#=GF RT   Structure and cleavage specificity of the chymotrypsin-like
#=GF RT   serine protease (3CLSP/nsp4) of Porcine Reproductive and
#=GF RT   Respiratory Syndrome Virus (PRRSV).
#=GF RA   Tian X, Lu G, Gao F, Peng H, Feng Y, Ma G, Bartlam M, Tian K,
#=GF RA   Yan J, Hilgenfeld R, Gao GF;
#=GF RL   J Mol Biol. 2009;392:977-993.
#=GF DR   INTERPRO; IPR008760;
#=GF DR   MEROPS; S32;
#=GF DR   SCOP; 1mbm; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Serine peptidases involved in processing nidovirus polyprotein.
#=GF SQ   33
#=GS RPOA_SHFV/1368-1665         AC Q68772.4
#=GS A0A089FYB2_9NIDO/1323-1615  AC A0A089FYB2.1
#=GS A0A0V0QLM1_PSEPJ/21-91      AC A0A0V0QLM1.1
#=GS A0A0B5JQL5_9NIDO/1484-1783  AC A0A0B5JQL5.1
#=GS A0A0B6CDG7_9NIDO/1342-1639  AC A0A0B6CDG7.1
#=GS A0A6B9PQ75_9NIDO/1677-1974  AC A0A6B9PQ75.1
#=GS A0A0G2UIN6_9NIDO/1322-1619  AC A0A0G2UIN6.1
#=GS A0A0Y0BQ57_9NIDO/1321-1617  AC A0A0Y0BQ57.1
#=GS B5L2W7_EAV/963-1269         AC B5L2W7.1
#=GS A0A0B5JKI4_9NIDO/1465-1765  AC A0A0B5JKI4.1
#=GS A0A5C2SC59_9APHY/259-379    AC A0A5C2SC59.1
#=GS A0A2T2ZUM1_9PEZI/8-83       AC A0A2T2ZUM1.1
#=GS A0A1Z2RX52_9NIDO/1253-1551  AC A0A1Z2RX52.1
#=GS A0A2P1GMT8_9NIDO/1384-1521  AC A0A2P1GMT8.1
#=GS A0A2P1GMT8_9NIDO/1531-1724  AC A0A2P1GMT8.1
#=GS B5L2W6_EAV/963-1269         AC B5L2W6.1
#=GS A0A167L705_9NIDO/1342-1645  AC A0A167L705.1
#=GS A0A2P1GMW5_9REOV/1132-1419  AC A0A2P1GMW5.1
#=GS A0A0G2UPV3_9NIDO/1322-1619  AC A0A0G2UPV3.1
#=GS A0A2P1GMV4_9NIDO/1810-2118  AC A0A2P1GMV4.1
#=GS M1YYQ6_NITG3/264-373        AC M1YYQ6.1
#=GS A0A1Z2RX77_9NIDO/1253-1551  AC A0A1Z2RX77.1
#=GS A0A2H4MWN4_9NIDO/1659-1956  AC A0A2H4MWN4.1
#=GS Q6PR44_PRRSV/1717-2014      AC Q6PR44.1
#=GS RPOA_PRRSL/1601-1897        AC Q04561.3
#=GS RPOA_EAVBU/963-1269         AC P19811.3
#=GS RPOA_EAVBU/963-1269         DR PDB; 1MBM A; 7-204;
#=GS RPOA_EAVBU/963-1269         DR PDB; 1MBM C; 7-197;
#=GS RPOA_EAVBU/963-1269         DR PDB; 1MBM D; 9-203;
#=GS RPOA_EAVBU/963-1269         DR PDB; 1MBM B; 7-198;
#=GS G9FGR7_9NIDO/1275-1576      AC G9FGR7.3
#=GS RPOA_PRRSB/1717-2014        AC Q8B912.3
#=GS A0A0B6C113_9NIDO/1346-1643  AC A0A0B6C113.1
#=GS A0A159D6R9_9NIDO/1344-1644  AC A0A159D6R9.1
#=GS A0A089G1D3_9NIDO/1323-1615  AC A0A089G1D3.1
#=GS G9FGR6_9NIDO/1275-1576      AC G9FGR6.3
#=GS A0A0Y0BX48_9NIDO/1321-1617  AC A0A0Y0BX48.1
RPOA_SHFV/1368-1665                    ....................................LSMKYIAFFc..ctTAF...VDFTSVVVV..LT..A...LLVGWILARYT.GIG..GFVTPYDIHDV..VKSQRDG.....VAVANAPPNTYLGAVRRAALTGKPAFFVANNTGIV...L.EGLLREK.TRASNSVSV.YGVTCGSGGLFS..DGNNTVCLTATHVCG.NN.KA....VVDY.QG...TRYE.AV.FTTKGDYASAVV....-P.IPGA.FPP.LKFA.pQSYTGRAYWYANTGVETGFVG....T....TGCLVF...SGPGDSGSPIITPD...GLIVGV.HTGSD..S.KGSGAYTTPNGLTVS-GPLSLKEMGA..HY...EGPIVDVPT.-RLPRNVHNDTKSVPQPLARLLESSINLEG................
#=GR RPOA_SHFV/1368-1665         pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A089FYB2_9NIDO/1323-1615             ............................lllltalt---------.....TSL...VDLPASLVC..CI..L...FGSAWVVGKCT.GVG..GLVTPYDIHLC..AKTPRDS.....IAIANAAPNTYLGAVRMAALSGTNKFFVGSNAGII...L.EGLLREK.TKADNTCSV.FGVTAGTGGLYS..RDGKVICVTASHVCG.DG.EA....MIKL.GD...TSTY.AT.FKRCGDYAEAEV....-N.IPGV.FPA.YVPA..NNYQGRAYWLTSTGVETGFVT....H....QGAVVF...SGPGDSGSPIITPT...GEIIGV.HTGSD..S.KGSGAYSQSNGRLVT-GPVKLSDMAA..YY...EGPLVSVET.-RLPGNVTKDVESIPKTLATLLANSIHLEG................
#=GR A0A089FYB2_9NIDO/1323-1615  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A0V0QLM1_PSEPJ/21-91                 ............kpvnikllinsqksiglgkiidfs---------.....---...---------..--..-...-----------.---..-----------..-------.....-----------------------------------...-.-------.---------.------------..---------------.--.--....----.--...----.--.------------....--.----.---.----..---------------------....-....QFILCYegtTACGSSGSPVIDQN...GNLLGI.NTGS-..-.--------------------------..--...---------.------------------------------fdditenekvskvq..
A0A0B5JQL5_9NIDO/1484-1783             ..............................vvlang-------VF.....LLL...VSRPAALIY..WA..F...LVVSYL-QKFV.ASPaiHLITPHTLGEI..TNNPLAA.....MAVANAKPGSYQHTAKTAALTGRCYLHIPSHASVL...L.EGKLRSK.QRSANTVIC.SGSSCGVGTIWK..RNNKHVLLTATHLAA.ED.KTgkyvLVDV.ES...LTMR.VD.LTCKGDYAEGEI....QT.RLGNvYPA.LQLA..TGYQGRAYWLTASGVDVGIVT....D....KLAVCY...TNPGDSGSAVVCPE...GKFIGV.HTGSN..Q.RGFGIVTCPDGKVRG-GQGKLSELVQ..YY...DGPLVPRPA.-SLPVNVVPDVEMIPKTLATVLDGVVVNEG................
#=GR A0A0B5JQL5_9NIDO/1484-1783  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A0B6CDG7_9NIDO/1342-1639             ..................................ls--TKVIGFYl..asTVL...ISPAAACIS..AI..G...MACAWIVGAFT.GTV..GLVTPFDIHRL..SRSSRDA.....VAIANAPANTFLGAVRKAALTGKPTYFLADNTGIV...L.EGLLRHS.KPADSSVSV.FGVACGSGGLFS..DKGKTVVVTATHVCG.QQ.PA....IVKT.GG...EERS.VT.FQTIGDFAHAEI....-D.LPGS.FPA.FKIA.pPTYMGRAYWYCNNGVETGFVT....P....HGCVVF...SGPGDSGSPIVTPD...GQLIGV.HTGSD..S.NGCGAYTRPDGTLVS-GGIQLSVAAP..HY...DGDLVDVPS.-RLPKNVVADAQKIPATLARLLSQSVLLEG................
#=GR A0A0B6CDG7_9NIDO/1342-1639  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A6B9PQ75_9NIDO/1677-1974             ....................................LTIVWVCFF.....LVT...CNPPAGFLA..MV..F...LLILWVLGRYT.QVA..GIVTPYDIHSH..TNGPRGA.....AALMNASDGTYLAAVRKAALTGRTMMFCPSNLGSL...L.EGAFRTQ.KPCSNTVNV.VGSSMGSGGVFT..YKGKKVCITAAHVLS.GN.SA....RVTG.PG...FNRM.LQ.FETHGDFAIAPC....ED.WVGQ.APE.TKDV.pKGWTGRAFWLTATGVEPGVMG....K....GFAFCF...TACGDSGSPVLTEA...GDLIGI.HTGSN..K.QGGGIVTSPDGTTCNIQDVALSELSK..YF...AGPLVPLGD.LKVGQHIIVDTHQLPSDLCALLAAKPTLEG................
#=GR A0A6B9PQ75_9NIDO/1677-1974  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A0G2UIN6_9NIDO/1322-1619             ...............................ltqrg-----IVIF.....TVTcalIDIPSLVTI..CI..L...AISAWVLGKYT.GVG..GLVTPYDIRNV..VKTARDS.....VAVANAPPNTYLGAVRRAALTGGCVYYIADNTGIV...L.EGLLREK.TPAPNAVRV.FGKTTGTGALLR..KGGKTVCISAQHVTG.EG.KA....IIRH.NG...VEYE.AQ.FATVGDFAEAEV....-Q.IPGS.FPE.YKLA.pPTYSGRAYWLCNDGVEVGFVT....P....QGCVVF...SGPGDSGSAIITPE...SQLIGI.HTGSD..S.KGCGAYTTPDGSTIT-GAVSLSHMTA..CY...EGPSVSVPE.-RLPRNVTRDVDSVPQPLATILQSSINLEG................
#=GR A0A0G2UIN6_9NIDO/1322-1619  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A0Y0BQ57_9NIDO/1321-1617             ........................vefrvlvfaiis---------.....SAL...LDPTASIVI..LI..L...LSLTWAIGKWT.GLG..GLVTPYDIHLV..SKTPRDA.....IAVANAPPNSYLGAVRMAALTNTNRFYVGSNTGTV...L.EGLLREK.SCADNTCRV.FGVTSGTGGLYS..RDGKVVCVTASHVCG.EQ.PA....VIRY.QD...EQHT.AV.FERKGDYAEATV....-N.IPGT.FPS.YKLA..KDYCGRAYWLTSTGIETGFVT....P....SGAVVF...SGPGDSGSPIITPT...GELIGV.HTGSD..S.RGSGAYTNSSGTLVT-GPVSLSEMSS..HY...DGKKTTVAG.-RLPRNVVVDATEIPSALATILSNSVNLEG................
#=GR A0A0Y0BQ57_9NIDO/1321-1617  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
B5L2W7_EAV/963-1269                    ....................................LATLFVNLFfpqatLVT...MGYWACVAA..LA..V...YSLMGLRVK-V.NVP..MCVTPAHFLLL..ARSAGQSreqmlRVSAAAPTNSLLGVARDCYVTGTTRLYIPKEGGMV...F.EGLFRSP.KARGNVGFV.AGSSYGTGSVWT..RNNEVVVLTASHVVGrAN.MA....TLKI.GD...AMLT.LT.FKKNGDFAEAVTt..qSE.LPGN.WPQ.LHFA..QPTTGPASWCTATGDEEGLLS....G....EVCLAW...TTSGDSGSAVVQGD...A-VVGV.HTGSN..T.SGVAYVTTPSGKLLGADTVTLSSLSK..HF...TGPLTSIPK.-DIPDNIIADVDAVPRSLAMLIDGLSNRES................
#=GR B5L2W7_EAV/963-1269         pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A0B5JKI4_9NIDO/1465-1765             .............................vvvlang-------VF.....LLL...VSRPAALIY..WA..F...LVVSYL-QKFV.ASPaiHLITPHTLGEI..TNNPLAA.....MAVANAKPGSYQHTAKTAALTGRCYLHIPSHASVL...L.EGKLRSK.QRSANTVIC.SGSSCGVGTIWK..RNNKHVLLTATHLAA.ED.KTgkyvLVDV.ES...LTMR.VD.LTCKGDYAEGEI....QT.RLGNvYPA.LQLA..TGYQGRAYWLTASGVDVGIVT....D....KLAVCY...TNPGDSGSAVVCPE...GKFIGV.HTGSN..Q.RGFGIVTCPDGKVRG-GQGKLSELVQ..YY...DGPLVPRPA.-SLPVNVVPDVEMIPKTLATVLDGVVVNEG................
#=GR A0A0B5JKI4_9NIDO/1465-1765  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A5C2SC59_9APHY/259-379               ........................rtpedlanpdty---------.....---...---------..--..-...-----------.---..-----------..-------.....-----------------------------------...-.-------.---------.------------..---------------.--.--....----.--...----.--.-DSNGEPCVVVM....--.KDGN.TSD.LTVG..RYAGLEAYTCDNLGVESIELAiynyD....KQSGSF...SAKGDSGSLVFDGQ...GRMVGIlHSGLA..Q.SGSNYVTYATPAWWVIEQLKL-----..--...---------.------------------------------qyphadf.........
A0A2T2ZUM1_9PEZI/8-83                  ..........................vtkeivvvpt---------.....---...---------..--..-...-----------.---..-----------..-------.....-----------------------------------...-.-------.---------.------------..---------------.--.--....----.--...----.--.------------....--.----.---.----..-----------------PFHG....K....KKAFAF...SAKGDSGSIVFDKR...GAIVGM.VVASN..SpAGSGLHDYTEAD--------------..--...---------.------------------------------vtfvspiqwvlddiqk
A0A1Z2RX52_9NIDO/1253-1551             ..............................ntisyl-------VF.....LVI...VSFVSPVGL..LGnlA...FCLVAALLRFVpGAP..VVITPWDLARF..VSNPKNA.....ASVANATPGSYVHALRTSALTGRNMIYIPTTQGIT...L.EGLRRKP.LVPCNVTTV.VGSATGVGSLWT..IAGKRSIITASHLLEdDD.TA....VVTL.GA...DAST.VK.FQRRGDFAIGAS....PF.LGFV.HPD.AEFG..-KPTGPAYWLTTSGTELGFVN....D....TICVCY...TDCGDSGSPVLNNE...RRILGV.HTGSN..K.RGLGVITMQDGSQLGYGKTNLSALVP..HF...GGELVTVSD.AEVPVNLVRDVEMIPKGLYDAISSRMNLEG................
#=GR A0A1Z2RX52_9NIDO/1253-1551  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A2P1GMT8_9NIDO/1384-1521             ...............................atpyl------ILL.....III...LNPFAAIHHgfDG..A...IVKSGLLSKDP.RCP..VYVTPTTLSEI..SAANGVTlttaiTKSAADPEDSLSNCAFRCMMDGKARIFIPKVRNMVrflQ.ESKARSQ.TKTQSTVMLtSGISVGSGALFT..ASGS-----------.--.--....----.--...----.--.------------....--.----.---.----..---------------------....-....------...--------------...------.-----..-.--------------------------..--...---------.------------------------------qirh............
A0A2P1GMT8_9NIDO/1531-1724             .........................pgfvttasdmy---------.....---...---------..--..-...-----------.---..-----------..-------.....-----------------------------------...-.-------.---------.------------..----ILLLTASHNLQ.GSiRV....TLSEgSS...FKIMeNQ.FFKKNDLAVSILepehSNiVTFN.IPR.LTQT..VDYTGPAFWSTRTGVEPGFTA....RskegNLFFCF...TDPGDSGSAVIDSS...GGLIGI.HSGSN..Q.RGRCVVTDLCGRMAPLNDIYLSEVAP..HF...RGPLVPVPE.--LPPGLVKDVNLIPSLLATMLTE------nnvrpe..........
#=GR A0A2P1GMT8_9NIDO/1531-1724  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
B5L2W6_EAV/963-1269                    ....................................LATLFVNLFfpqatLVT...MGYWACVAA..LA..V...YSLMGLRVK-V.NVP..MCVTPAHFLLL..ARSAGQSreqmlRVSAAAPTNSLLGVARDCYVTGTTRLYIPKEGGMV...F.EGLFRSP.KARGNVGFV.AGSSYGTGSVWT..RNNEVVVLTASHVVGrAN.MA....TLKI.GD...AMLT.LT.FKKNGDFAEAVTt..qSE.LPGN.WPQ.LHFA..QPTTGPASWCTATGDEEGLLS....G....EVCLAW...TTSGDSGSAVVQGD...A-VVGV.HTGSN..T.SGVAYVTTPSGKLLGADTVTLSSLSK..HF...TGPLTSIPK.-DIPDNIIADVDAVPRSLAMLIDGLSNRES................
#=GR B5L2W6_EAV/963-1269         pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A167L705_9NIDO/1342-1645             .................laakfmnfrhiclglalva---------.....--P...FDPYAAVTG..LI..I...LGCCVLSARYT.GFG..GLVTPYDIHAY..TTNPRQA.....IALANAREGTYLASVRQAALTGKPAWFVPSNFGIM...V.EGALRTG.KPHFATCGV.TGSSTGTGAIFD..HKGKQVAVTATHVLSeDK.TA....FVNH.SG...LTKC.IS.FKTKGDFAIGEV...vPP.FPGD.FPP.YVPT..EAYEGRAYWLCAGGIDVGYLS....K....QGAVVF...TGPGDSGSAIITAS...GQVLGV.HTGSD..S.NGCGAYTTPSGTT-TVGSLKLSVIAK..HY...EGDLVPVET.--VPKNVQADVTMIPRPLANIFKNSL----hlqg............
#=GR A0A167L705_9NIDO/1342-1645  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A2P1GMW5_9REOV/1132-1419             ...................nlrllllvivmillaip---------.....---...---------..--..-...---LLTLSLHP.SAP..TVVTPWTSCSLmlKYGVSSS.....EMCALSLSSPFIKAALDCSTRGTFSLYKPPTI--I...P.EAAEASRpHNSAWVGSV.YGA-NGNGICFV..SGKK--IYSTRHALT.N-.GA....VCTF.KD...FSVE.ANnVIYSGETAC-FT....PD.VDCC.MPMgPKFVdqRAYSGRVSVLGALEH-RGVIV....N....GGYFVQ...SDPGDSGSPVLATDlptDVVIGV.HYGSN..K.SGFASYSNLAGELNSFNGCSLSDLNQ..RS...AGNLVPLPSsFVLPSGITRDTNIIATDLLS----------cftrvtpe........
A0A0G2UPV3_9NIDO/1322-1619             ...............................ltqrg-----IVIF.....TVTcalIDIPSLVTI..CI..L...AISAWVLGKYT.GVG..GLVTPYDIRNV..VKTARDS.....VAVANAPPNTYLGAVRRAALTGGCVYYIADNTGIV...L.EGLLREK.TPAPNAVRV.FGKTTGTGALLR..KGGKTVCISAQHVTG.EG.KA....IIRH.NG...VEYE.AQ.FATVGDFAEAEV....-Q.IPGS.FPE.YKLA.pPTYSGRAYWLCNDGVEVGFVT....P....QGCVVF...SGPGDSGSAIITPE...SQLIGI.HTGSD..S.KGCGAYTTPDGSTIT-GAVSLSHMTA..CY...EGPSVSVPE.-RLPRNVTRDVDSVPQPLATILQSSINLEG................
#=GR A0A0G2UPV3_9NIDO/1322-1619  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A2P1GMV4_9NIDO/1810-2118             lhyflinaglyiaiflvltfsnvsfgfsgtafrlhg---------.....---...---------..--..-...---------FG.LLP..CVVTPNTIVQY..SNATNSSlqsvmTRAASAPNGTILAACLDAHINNTNYLYLPRDQGVI...IkESGLRSS.IPSKFVFKV.ISDTTTSTGFMAkdRNGNVTLYTTKHALA.SD.RL....ILKF.PSgdiTCSR.SQ.WKVEGENASLKY...vGP.DADK.AAM.MEWD..NPSNGLVTLHTCTGTDTAVWC....S....RTYVSQ...STAGDSGSPVTQG-...GKLVGI.HYGSN..K.AGYAVMSDQYGSLSSTNLVRLSEVDK..FF...SGPMIATPS.-FSSLAIEIDTEMIHSDTAQAL--------trhaeqs.........
M1YYQ6_NITG3/264-373                   ........................eqqimifpvgye---------.....---...---------..--..-...-----------.---..-----------..-------.....-----------------------------------...-.-------.---------.------------..---------------.--.--....----.--...----.--.------------....--.----.---.----..---------------------....-....TGNVCF...SARGDSGSAVVNED...NKIVGL.LFGSNgiT.NTSTSVEYRAGVACPITNV-LNELQVdlVFgqpAGHIFTVPE.-PVSESVALASEAVPS--------------papasmte........
A0A1Z2RX77_9NIDO/1253-1551             ..............................ntisyl-------VF.....LVI...VSFVSPVGL..LGnlA...FCLVAALLRFVpGAP..VVITPWDLARF..VSNPKNA.....ASVANATPGSYVHALRTSALTGRNMIYIPTTQGIT...L.EGLRRKP.LVPCNVTTV.VGSATGVGSLWT..IAGKRSIITASHLLEdDD.TA....VVTL.GA...DAST.VK.FQRRGDFAIGAS....PF.LGFV.HPD.AEFG..-KPTGPAYWLTTSGTELGFVN....D....TICVCY...TDCGDSGSPVLNNE...RRILGV.HTGSN..K.RGLGVITMQDGSQLGYGKTNLSALVP..HF...GGELVTVSD.AEVPVNLVRDVEMIPKGLYDAISSRMNLEG................
#=GR A0A1Z2RX77_9NIDO/1253-1551  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A2H4MWN4_9NIDO/1659-1956             ....................................LTILWVQFF.....LVV...CNAPAAMLA..FV..L...LVCLWVLGKYT.QVA..GLVTPYDIHAY..TGTPRGA.....ASVASAPDGTFLAAVRKSALTGRTMMFAPSTTGAI...L.EGAFRSQ.KPSLNTVNV.VGSSMGSGGVFE..YKGKKICVTATHVLS.GH.SA....RVTG.PG...FNRM.VE.FKVTGDYAIAEL....PD.WQGV.APK.CDFA.pAKWSGRAFWLTSSGVEPGVIG....T....NFAFCF...TNCGDSGSPVLTDG...GDLIGI.HTGSN..K.VGGGIVTRPDGSTVTIQNVKLSELSK..FF...AGPAVPLGD.IKVGPHVVVDSAYVPSDLAAMLASSPTAEG................
#=GR A0A2H4MWN4_9NIDO/1659-1956  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
Q6PR44_PRRSV/1717-2014                 ....................................LTILWLVFF.....LIS...VNMPSGILA..MV..L...LVSLWLLGRYT.NVA..GIVTPYDIHHY..TSGPRGV.....AALATAPDGTYLAAVRRAALTGRTMLFTPSQLGSL...L.EGAFRTR.KPSLNTVNV.IGSSMGSGGVFT..IDGKVKCVTAAHVLT.GN.SA....RVSG.VG...FNQM.LD.FDVKGDFAMADC....PN.WQGA.APK.TQFC.tDGWTGRAYWLTSSGVEPGVIG....K....GFAFCF...TACGDSGSPVITEA...GELVGV.HTGSN..K.QGGGIVTRPSGQFCNVAPIKLSELSE..FF...AGPKVPLGD.VKVGSHIIKDISEVPSDLCALLAAKPELEG................
#=GR Q6PR44_PRRSV/1717-2014      pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
RPOA_PRRSL/1601-1897                   ....................................LTMLWVHSF.....LVF...CLPAAGILS..LG..I...TGLLWAIGRFT.QVA..GIITPYDIHQY..TSGPRGA.....AAVATAPEGTYMAAVRRAALTGRTLIFTPSAVGSL...L.EGAFRTH.KPCLNTVNV.VGSSLGSGGVFT..IDGRRTVVTAAHVLN.GD.TA....RVTG.DS...YNRM.HT.FKTNGDYAWSHA....DD.WQGV.APV.VKVA..KGYRGRAYWQTSTGVEPGIIG....E....GFAFCF...TNCGDSGSPVISES...GDLIGI.HTGSN..K.LGSGLVTTPEGETCTIKETKLSDLSR..HF...AGPSVPLGD.IKLSPAIIPDVTSIPSDLASLLASVPVVEG................
#=GR RPOA_PRRSL/1601-1897        AS    ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
RPOA_EAVBU/963-1269                    ....................................LATLFVNLFfpqatLVT...MGYWACVAA..LA..V...YSLMGLRVK-V.NVP..MCVTPAHFLLL..ARSAGQSreqmlRVSAAAPTNSLLGVARDCYVTGTTRLYIPKEGGMV...F.EGLFRSP.KARGNVGFV.AGSSYGTGSVWT..RNNEVVVLTASHVVGrAN.MA....TLKI.GD...AMLT.LT.FKKNGDFAEAVTt..qSE.LPGN.WPQ.LHFA..QPTTGPASWCTATGDEEGLLS....G....EVCLAW...TTSGDSGSAVVQGD...A-VVGV.HTGSN..T.SGVAYVTTPSGKLLGADTVTLSSLSK..HF...TGPLTSIPK.-DIPDNIIADVDAVPRSLAMLIDGLSNRES................
#=GR RPOA_EAVBU/963-1269         SS    ....................................XXXXXXXXXXXXXXXXX...XXXXXXXXX..XX..X...XXXXXXXXX-X.XXX..XXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...X.XXXXXXX.---TTEEEE.ESSSEEEEEEEE..CTTEEEEEEEHHHH-TTS.EE....EEEE.TT...EEEE.EE.EEEETTEEEEEE-..TTT.S-S-.--B.--B-..---SEEEEEEETTEEEEEEE-....S....S-EE--...--GGGTT-EEEETT...E-EEEE.EEEEE..T.TTEEEEE-TT--EETSS-EEHHHHHT..T-...-SSEEE--S.----TTEE--SSEEEHHHHHHHCTXSXXXX................
#=GR RPOA_EAVBU/963-1269         pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
G9FGR7_9NIDO/1275-1576                 .................................vvi---ILVATF.....MVW...SSCGGSMAS..VN..IngpVVSPLLLMSNG.TAP..SVVTPTTLACA..AQSAGVPfaslvARAAVSRPGTVLKAAYDSAKDGKVRIYIPTGTGVV...Q.EGAMRCN.RVPSNVGVA.TGATTGTASGWS..YGENSRIITATHVTG.TP.TF....VTIG.TQ...TFTI.PQ.FNTNGDFAYVDI....-N.GNYG.WPE.YKTG..-QFEGPCFWLTRTGVETGAVV....G....KAAVAF...THPGDSGSPVVTKD...NVILGV.HSASN..Q.RGLAVITDCSGVEIGYQPVQLSKMVK..LF...SGPLTRAPA.-VMPANIVRDIESVPETLANALNGQLNYEG................
#=GR G9FGR7_9NIDO/1275-1576      pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
RPOA_PRRSB/1717-2014                   ....................................LTILWLVFF.....LIS...VNIPSGILA..VV..L...LVSLWLLGRYT.NIA..GLVTPYDIHHY..TSGPRGV.....AALATAPDGTYLAAVRRAALTGRTMLFTPSQLGSL...L.EGAFRTQ.KPSLNTVNV.VGSSMGSGGVFT..IDGKIKCVTAAHVLT.GN.SA....RVSG.VG...FNQM.LD.FDVKGDFAIADC....PN.WQGA.APK.AQFC.eDGWTGRAYWLTSSGVEPGVIG....N....GFAFCF...TACGDSGSPVITEA...GELVGV.HTGSN..K.QGGGIVTRPSGQFCNVTPIKLSELSE..FF...AGPKVPLGD.VKIGSHIIKDTCEVPSDLCALLAAKPELEG................
#=GR RPOA_PRRSB/1717-2014        pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A0B6C113_9NIDO/1346-1643             ..................................ls--TKVIGFYl..asTVL...ISPAAACIS..AI..G...MACAWIVGAFT.GTV..GLVTPFDIHRL..SRSSRDA.....VAIANAPANTFLGAVRKAALTGKPTYFLADNTGIV...L.EGLLRHS.KPADSSVSV.FGVACGSGGLFS..DKGKTVVVTATHVCG.QQ.PA....IVKT.GG...EERS.VT.FQTIGDFAHAEI....-D.LPGS.FPA.FKIA.pPTYMGRAYWYCNNGVETGFVT....P....HGCVVF...SGPGDSGSPIVTPD...GQLIGV.HTGSD..S.NGCGAYTRPDGTLVS-GGIQLSVAAP..HY...DGDLVDVPS.-RLPKNVVADAQKIPATLARLLSQSVLLEG................
#=GR A0A0B6C113_9NIDO/1346-1643  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A159D6R9_9NIDO/1344-1644             ...................syvsfknlglglalvap---------.....---...LDPVAACAG..LL..I...LGCCYLVGRFT.GFG..GLITPYDIHAH..TGNPRQA.....IAVANAKDGTYLAAVRQAALTGKPAWFIPSNFGIM...V.EGALRTG.KPHFATCGV.TGSSTGTGAILN..RNGKQVVVTATHVLSeDK.SA....FVSH.SG...LTRS.VK.FIAKGDFAIGDV...dTP.FPGD.FPQ.YIPA..AHYEGRAYWLCAGGIDVGYLS....P....TGAVVF...TGPGDSGSAIINAS...GQLLGV.HTGSD..A.NGCGAYTTPAGDTIV-GSLKLSLLAK..HY...EGDLVPVDT.--VPRNVICDVTMIPQPLADILKNSLR---lqg.............
#=GR A0A159D6R9_9NIDO/1344-1644  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A089G1D3_9NIDO/1323-1615             ............................lllltalt---------.....TSL...VDLPASLVC..CI..L...FGSAWVVGKCT.GVG..GLVTPYDIHLC..AKTPRDS.....IAIANAAPNTYLGAVRMAALSGTNKFFVGSNAGII...L.EGLLREK.TKADNTCSV.FGVTAGTGGLYS..RDGKVICVTASHVCG.DG.EA....MIKL.GD...TSTY.AT.FKRCGDYAEAEV....-N.IPGV.FPA.YVPA..NNYQGRAYWLTSTGVETGFVT....H....QGAVVF...SGPGDSGSPIITPT...GEIIGV.HTGSD..S.KGSGAYSQSNGRLVT-GPVKLSDMAA..YY...EGPLVSVET.-RLPGNVTKDVESIPKTLATLLANSIHLEG................
#=GR A0A089G1D3_9NIDO/1323-1615  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
G9FGR6_9NIDO/1275-1576                 .................................vvi---ILVATF.....MVW...SSCGGSMAS..VN..IngpVVSPLLLMSNG.TAP..SVVTPTTLACA..AQSAGVPfaslvARAAVSRPGTVLKAAYDSAKDGKVRIYIPTGTGVV...Q.EGAMRCN.RVPSNVGVA.TGATTGTASGWS..YGENSRIITATHVTG.TP.TF....VTIG.TQ...TFTI.PQ.FNTNGDFAYVDI....-N.GNYG.WPE.YKTG..-QFEGPCFWLTRTGVETGAVV....G....KAAVAF...THPGDSGSPVVTKD...NVILGV.HSASN..Q.RGLAVITDCSGVEIGYQPVQLSKMVK..LF...SGPLTRAPA.-VMPANIVRDIESVPETLANALNGQLNYEG................
#=GR G9FGR6_9NIDO/1275-1576      pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
A0A0Y0BX48_9NIDO/1321-1617             ........................vefrvlvfaiis---------.....SAL...LDPTASIVI..LI..L...LSLTWAIGKWT.GLG..GLVTPYDIHLV..SKTPRDA.....IAVANAPPNSYLGAVRMAALTNTNRFYVGSNTGTV...L.EGLLREK.SCADNTCRV.FGVTSGTGGLYS..RDGKVVCVTASHVCG.EQ.PA....VIRY.QD...EQHT.AV.FERKGDYAEATV....-N.IPGT.FPS.YKLA..KDYCGRAYWLTSTGIETGFVT....P....SGAVVF...SGPGDSGSPIITPT...GELIGV.HTGSD..S.RGSGAYTNSSGTLVT-GPVSLSEMSS..HY...DGKKTTVAG.-RLPRNVVVDATEIPSALATILSNSVNLEG................
#=GR A0A0Y0BX48_9NIDO/1321-1617  pAS   ........................................................................................................................................................................................................*....................................*........................................................................*....................................................................................................................
#=GC SS_cons                           ....................................XXXXXXXXXXXXXXXXX...XXXXXXXXX..XX..X...XXXXXXXXX-X.XXX..XXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...X.XXXXXXX.---TTEEEE.ESSSEEEEEEEE..CTTEEEEEEEHHHH-TTS.EE....EEEE.TT...EEEE.EE.EEEETTEEEEEE-..TTT.S-S-.--B.--B-..---SEEEEEEETTEEEEEEE-....S....S-EE--...--GGGTT-EEEETT...E-EEEE.EEEEE..T.TTEEEEE-TT--EETSS-EEHHHHHT..T-...-SSEEE--S.----TTEE--SSEEEHHHHHHHCTXSXXXX................
#=GC seq_cons                          ..................................h.........h.....hhh...hs.sushhh..hh..h...hs.hhlls+as.sss..slVTPacltth..spsspsu.....hulAsAsssoaLuAsRpuALTGpshhalssstGhl...l.EGhhRpp.psssNsstV.hGsosGoGulas..hss+hhhlTAoHVhu.ss.pA....hlph.ss...hphh.sp.FpppGDaA.uth.....s.hsGs.aPt.hphu..tsapGcAaWhTsoGlEsGhls....s....phslsF...ossGDSGSsVlsss...GpllGV.HTGSs..p.pGsGhhTpssGphhs.sslpLSchst..aa...sGslVslss..plPtNlltDsp.lPpsLAslLss...hEG................
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