#=GF ID   Phlebovirus_NSM
#=GF AC   PF07246.16
#=GF DE   Phlebovirus nonstructural protein NS-M
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_17508 (release 10.0)
#=GF GA   27.20 27.20;
#=GF TC   27.20 27.20;
#=GF NC   26.40 26.20;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -E 1000 -Z 90746521 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR009879;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several Phlebovirus nonstructural NS-M
#=GF CC   proteins which represent the N-terminal region of the M
#=GF CC   polyprotein precursor. The function of this family is unknown.
#=GF SQ   23
#=GS A0A482KFQ4_9VIRU/10-277   AC A0A482KFQ4.1
#=GS A0A482KC17_9VIRU/12-274   AC A0A482KC17.1
#=GS I1T372_9VIRU/1-261        AC I1T372.1
#=GS A0A1U6ZHF1_9VIRU/4-304    AC A0A1U6ZHF1.1
#=GS A0A286XN02_CAVPO/457-614  AC A0A286XN02.1
#=GS A0A286XB91_CAVPO/457-614  AC A0A286XB91.1
#=GS GP_RVFVZ/89-144           AC P21401.1
#=GS I1T369_9VIRU/1-256        AC I1T369.1
#=GS F4ZCK5_9VIRU/2-276        AC F4ZCK5.1
#=GS U5XM01_9VIRU/5-187        AC U5XM01.1
#=GS A0A6M4ALR6_9VIRU/6-313    AC A0A6M4ALR6.1
#=GS A0A1S5SHT8_9VIRU/9-278    AC A0A1S5SHT8.1
#=GS A0A482KFT4_9VIRU/1-284    AC A0A482KFT4.1
#=GS A0A1S5SHV8_9VIRU/3-304    AC A0A1S5SHV8.1
#=GS A0A343X9V7_9VIRU/1-303    AC A0A343X9V7.1
#=GS A0A0C5ARY4_9VIRU/1-290    AC A0A0C5ARY4.1
#=GS A0A1S5SHW8_9VIRU/8-291    AC A0A1S5SHW8.1
#=GS A0A7G8PYJ9_9VIRU/1-276    AC A0A7G8PYJ9.1
#=GS A0A7G8PYK7_9VIRU/2-269    AC A0A7G8PYK7.1
#=GS A0A1S5SHW2_9VIRU/1-201    AC A0A1S5SHW2.1
#=GS GP_RVFVZ/1-95             AC P21401.1
#=GS A0A5C0E4I4_9VIRU/2-318    AC A0A5C0E4I4.1
#=GS A0A0S1MT47_PTPV/2-270     AC A0A0S1MT47.1
A0A482KFQ4_9VIRU/10-277              ...............tetlvlia-------L-LLGAVDS.K...YYLRSKNGDQ.GSSICLSNDSPVRVLRHYW-V.TMKS--ALGSDAMRCQIG.TSGDAYTTEKNALNLVADI...QRSTTYLSLFCH.fE.NDNAK..NI.N.LTFDGLSD..dLEGSH..VVDCDT.G..ISI.....---...-.-..--E....SPRLr......iDEP....I...PKK.VIgipa.....npmsSIVDNLISKeESAISEE...................--I..SRMGKSQIRTLQDA.....LAIERAS.....................RD.K.LIRD.LEMEKL.QTN...SIrGDMAALREK-----..................----...-----..------...-----------.....----------------lsrestkaqleleeekaklstiqrlllqeqkrianmeqakkdldikyai.............................................................................................
A0A482KC17_9VIRU/12-274              .....................fw--IFIILLGSTTLVRA.R...YQIDSHSAGT.YKKICLSNQSPARALEHYWNL.QRVS---LTDGRMACKIG.NSARSQSTSANIKLLIQTV...QETPTEINLHCR.iD.DDKGT..SI.N.LYFDGVED..nVDGAK..IVSCDD.S..TII.....SDV...R.L..MLDpssiIPKV.......vDAG....S...LPN.GS.............NNGDIIRNE.ITRTSIEdm...............agDTR..EEAVKFISRLDMEE.....MKSLRDQ.....................LA.E.IRAH.RDSLIRqLEK...QE.HETASIRSSLRSI-..................HELE...KADNEeaLRELRE...KNEKSERLQSA.....L---------------sqqi..........................................................................................................................................
I1T372_9VIRU/1-261                   ....................mky----LTILTLTTLLST.AycsYKLLAVHSKG.SSEICLSNLASLSALKRYW-V.DLDQ--EISAGDKHCSLG.SSGMSFSTNKTIMSLIAEV...QNSPSELALYCT..T.IDSAD..SI.G.LSFDGLSD..nFNKAK..ILNCKDpS..KSL.....GDI..eG.S..GNK....NLNM........ISD....Q...IRG.YRer.........iaEMEERLISEtKLLEAER...................EIR..NMELNDHSDRYYSN.....DVKLRAH.....................-E.E.IINK.RDMTIS.-KQ...S-.GIIMSL---QKNLT..................-ETM...RLLNN..IATHKP...K---LTTVLPV.....ITAISLLSSSMAE---lpi...........................................................................................................................................
A0A1U6ZHF1_9VIRU/4-304               ....................ifl--ITLVVVSALLLTLA.D...VRLDSVSAGK.EESICFSQNTKVLWIESYWGY.EMAK---MPGFDLYCRYNdEGDFKFMTNEKARQQIPLV...SGAPDSMRFSCG..D.MARDF..SV.T.LTNDGRNN...MMEGA..LIKCGT.K..EFI.....KSL...P.D..SVS....APTT........ESS....M...VHV.NStwere...lerveNAKKQ----.SVRLHEEvk..............valEGK..LSALTHELEKKEND.....LERTRDEl..................ksVK.MsMERK.MEAEDK.LQD...AQ.YIIEQLREKVALLTsrvvn........setdrEGLL...KAKNE..MKELRK...QVKTME-----.....----------------eenneirktfmqrpeanrsspliattmmallsta............................................................................................................
A0A286XN02_CAVPO/457-614             .....nevlqsflqsqttieksi----------------.-...----------.---------------------.------------------.-------------------...------------..-.-----..--.-.--------...-----..------.-..-LQ.....SDK...A.L..TDG....EKAI........AAE....R...AKK.EA.............AEKEQEVLRqKTEEQQQm.................mEAQ..ERSFQENMAQLKEK.....MEKERQD.....................IL.R.EQER.MLEHKL.KAQ...EE.LLRDGFRKKSEALN..................REIH...HLKEE..IEKTQD...KKSFFSKIVDT.....VGTVLV----------avlpgagklv....................................................................................................................................
A0A286XB91_CAVPO/457-614             .....nevlqsflqsqttieksi----------------.-...----------.---------------------.------------------.-------------------...------------..-.-----..--.-.--------...-----..------.-..-LQ.....SDK...A.L..TDG....EKAI........AAE....R...AKK.EA.............AEKEQEVLRqKTEEQQQm.................mEAQ..ERSFQENMAQLKEK.....MEKERQD.....................IL.R.EQER.MLEHKL.KAQ...EE.LLRDGFRKKSEALN..................REIH...HLKEE..IEKTQD...KKSFFSKIVDT.....VGTVLV----------avlpgagklv....................................................................................................................................
GP_RVFVZ/89-144                      .....................it----------------.-...----------.---------------------.------------------.-------------------...------------..-.-----..--.-.--------...-----..------.-..---.....---...-.-..---....----........---....-...---.--.............--------C.HGKDPED...................---..------KISLIKGP.....PHKKRVG.....................IV.R.CERR.RDAKQI.GRK...TM.AGIA----------..................----...-----..------...-----------.....----------------mtvlpalav.....................................................................................................................................
I1T369_9VIRU/1-256                   ..............miylpilll----------LRLTAA.S...FVLESTRPKGhSSKVCLSNTSSSKILERYW--.DNLE-QGMPNGPRMCSIG.SGESHLTSGANIKKLIRDV...RDSPTALNVSCV.vA.NQPEH..SI.S.IAFLEIPD..dFIKPT..SIDCVT.G..ESI.....REV...G.T..LDE....A---........---....-...---.--.............---------.-------...................---..--------------.....-------.....................--.-.----.------.---...--.--------------..................----...-----..------...-----------.....----------------asppdfhkpviiemdedtdflpprvlpasndirpvtldtrhghitrdeekialqlevdtlrdqlgverrqiaelnsimqntanmadsereqnqktisekhrqihdqtrqihelereimr.......................
F4ZCK5_9VIRU/2-276                   .............kifqyicyis------------VVVS.R...LVLHYSTPTY.SNKICFSSGSPESIVTNYW--.-MEVMESFPAGHQKCELG.DGQFSAVALDDMPKFIKAM...TTSDQALRLTCI..S.QNDSY..IS.E.LTTDGD-V...IPGEFhsEIDCKS.G..SII.....KEL...SkV..NVA....PAGVha...rdlLLE....D...AET.NAi...........lQQRDQLIAElREKLRDS...................KVR..EDAALQRSKVNTEL.....LSETKEK.....................AD.K.LQRR.ADELIL.HLEserAE.GRIS--RNRSKWLE..................HELK...DAKED..ISRLRL...DVGRTTT----.....----------------rkpksligltttiiplmllmtseat.....................................................................................................................
U5XM01_9VIRU/5-187                   .............flftalfgia--------------AC.M...FKLETESQRY.TNQICFSSSTPVKDMIRYWDS.EIRR---VPGTDYQCRFN.TDPFARTTSQGSRELLVSI...TSRTAENKYECL..S.QFNDS..RI.E.FSSDGYSE...EFEPA..AMMCDE.EkvDFL.....IQP...V.V..DQG....APAV........DLEselaK...LKQ.QA............kDDMNTLISE.HNKAIQE...................---..--------------.....-------.....................--.-.----.------.---...--.--------------..................----...-----..------...-----------.....----------------lnnlrsadvrklrevet.............................................................................................................................
A0A6M4ALR6_9VIRU/6-313               lvlltslaglseplikvgsihpg----------------.-...---------G.SSKVCLSNRTPAETVLYYWED.QFSK---LPQGQYLCQVG.SERKEEMDFKRIRKLVREV...GESITAVFFQCQ.yK.ENEGY..GI.N.VMFDGFDN..tEEGTY..IADCED.G.rKKI.....SDVrllS.S..GSR....GRTV........EHD....I...VMSpDAannrvrgdlktlqDKVDRMHLEhEKLNLENdklkdkm.....kneglltSSK..IQILQEKLDEAVDD.....LEDRKLE.....................--.R.DRAI.SDHKRT.LDE...-A.AELRVEINHLHKLIeaegdlkkelqrelnesrDQIY...NLKNA..PKSSVS...NKSISSYVTMA.....IPVITTLSLLGSA---aam...........................................................................................................................................
A0A1S5SHT8_9VIRU/9-278               ..................lkafa-----VLLTQSVIAEG.L...FMLKSFKPLS.SAQVCFSSRTPLDGIGVYWIS.EMDK---LVNPTKLCSLG.GSPPSLMTKTSAFMATRAV...ILSEEPSELVCE..S.EDRSE..GI.S.LSNNGEEE...DLGPA..IINCRT.R..EKQ.....EDI...R.V..RVS....A--L........EEN....D...I--.--.............---KRIIEM.TTEYPAT...................ESP..RKILRTEIRKMETS.....KEELNDE.....................IA.KlTARH.EALVNA.LRE...TM.TDRD--RENNRLLSe................kVEME...NEKRE..IEH---...-----------.....----------------kikslnnllesekltvkylreelkrlqhqsnlekdklkeemetfnrr...............................................................................................
A0A482KFT4_9VIRU/1-284               ......................m-KILLYVK-QMVLTLA.V...YTLSSWSIEG.TTRLCMSNESPLEGLVYYWED.KMKKNKLTIDKLSGCRIG.EGDLQEMVNKTIIKMIEEV...QLSMSPLRFSCH..Q.SLNES..GI.S.IDFNGLDD..tDSGYH..IVDCNN.H..KIY.....EDL...G.V..LVG....DGTAw.....esRYN....K...SFN.EEiavktn.qlrlalSDLDRLTDL.RVDDQNEin...............slIRE..NQMLQHKISNITGV.....AYNYNNS.....................LQ.A.LLDD.LHKRDV.EYE...LM.-KIR--EQELKNLL..................DEQN...RTMDK..LKAVRTpadKYVMTTT-PKT....iLMTTLAVSLLSSS---sait..........................................................................................................................................
A0A1S5SHV8_9VIRU/3-304               .....................tk-----NILYLALLSCS.Ea.aIRIRGRKELG.RSEVCFSDQSPDEAVIVYWLS.ELDK---VYSSDFSCSYS.GSDYTGMDRTGINNRINELlseNKRNVSVSLACL..G.KDRAI..EM.E.TLNLITEN...--RPM..IVNCDT.G..DFL.....AEI...R.T..ISG....RKRV........HIE....K...SP-.--.............-ELVSTVLS.EVKSRDE...................D--..--------------.....-------.....................--.-.----.------.---...--.--------------..................----...-----..------...-----------.....----------------ykslyqdilgqynkvtddllrlqseklnldsekegkieklkdtidmlegvveklradnlkerslstrlenelailaheklkakepdtdvavstqvlnggditsneirrshgktikqdkeasyttlapiiavtllasvttvns
A0A343X9V7_9VIRU/1-303               ......................m-FKKLVVLTLALGQGDcL...YKITSLNQGA.RHELCMSNPTSFESVIDYWG-.SMDR--ALGEGDRECDIG.GGVKSYTTASTTKKLVRTV...VDSMTALNMSCS..I.KDSPD..KL.IhLMFDAEYD..gHLAPM..IVSCID.G..SAQ.....GPL...R.IagSHS....TNKI.......iHFP....KgasVEE.GTsppe....vsekpDDLSDEISY.RI----KsltsgnndpgslvhvisskDHE..LSTLKEEINSLKSR.....LEHERED.....................--.-.----.--RDRL.RAE...HK.AQIGHGDAERKLLEdrlrare....qdihndrAELQ...QLKAK..LRSLEN...ARVPVTTIAPKaittaLTVVSLLSAVG-----adln..........................................................................................................................................
A0A0C5ARY4_9VIRU/1-290               ...................myql---IVLILQRIVLAES.K...VSLTITSPDY.SSLSCFNSAVSAKFVQRKWAT.EVSK---MGDFDQFCYYN.NDIPKRSTGENSQGIMTFV...VLSDVPYTFSCV..S.EDRSK..LA.I.VHNDGVPS...DGEPA..YIDCEK.G..SMIhllssSDP...D.V..PKS....NPALe......eEHE....L...LKE.RF.............DDLQLKFND.NVRRLEA...................--E..NQDLKVRLDQLHSSreslkLQKSEQEgnlt............qlnaiIHdL.TKKV.RDGENA.VLN...LL.SEARRDKEALIQLEedt...........drrlEEND...RLIAS..LKARAH...NIIRAPTTVKP.....LITTAI----------avtllssallv...................................................................................................................................
A0A1S5SHW8_9VIRU/8-291               ......ffvsfalssyiltnlrp----------------.-...--------GG.SSKVCLSNTTSDKTLIEYWERlESPS-GEHINRTRSCRLG.DAPYSFSTSRNIRNLIKEV...QKSPSEMTLECN..M.NEEGT..ETiS.LRFDALSGs.dHIQPS..SIDCDT.G..EVI.....APV...R.S..TYRa..vEKKI.......pDQD....S...STP.AAav........mtvPAVDLEYER.KIK----...................DLE..VQLANVKIELLSER.....EQVESIKanlqnqvglsdnairsaddiiRK.K.NEEI.RSLQLS.TRN...LD.HEINKLKNSHGRLE..................EDLReerRAKHE..MNRSLQ...-ASFMTTVIPV.....VTTIALLSDV------alaa..........................................................................................................................................
A0A7G8PYJ9_9VIRU/1-276               .....................mm--ILVLVFLLTPCVLG.F...TRIYSDSSSG.VSETCFSSSTTFTWAVRQWMS.EMTR---LPHTEKFCLLNsEEKAKYMTDEEAVGMIETL...VGLKKPANFSCT..D.IKNSF..IL.G.LEVKPQVE...SHRSS..SIDCKD.F..TMI.....RPL...S.EmkPED....LKPIat...skdDAK....N...LEK.LE.............EELKKLKAF.NDKTLAEnlkla........tsldheLTK..SRMSMDDVRKTVSE.....LEKIKDE.....................--.M.AIKR.EEISEV.QRQ...L-.-------------Kaekeas.....qryqqeiDNLK...AIHQR.rTNELRT...NSSVLSTTIKA.....ITVLSVMSSAS-----aef...........................................................................................................................................
A0A7G8PYK7_9VIRU/2-269               ...................iikv----FIVVSTIGAVLG.Y...TKVFSNSSVG.YFETCYSSQTISQWIVRQWMT.DLNR---LPRDDKYCDLHtHKSNSYMTDDVIISVIETL...QTLDQDAHIICS..N.EDKTFtiGV.Q.VFYPPDGN...LAG--..TIDCNS.K..LLL.....REL...N.N..--E....IPPV........---....-...-KE.NS.............--KEDSI--.--KEMEK...................EIKalKESLDEKIKSNENL.....RRSLDSE.....................IL.K.NRDKaNEADIT.IDE...LN.AAREAILQKEKELHn...............llKEID...QEKKL..SDSYRQ...E----------.....----------------llslrraaekpvavhptrspirapvittamtilaavlsa.......................................................................................................
A0A1S5SHW2_9VIRU/1-201               ....................mky----FIVLTILGLVDA.T...FKLATMTPNR.KQEVCIDSGATLNQMQSIW--.DDLN-NSLATGTRSCTLE.EGTFSFVNERDYKTLLQAV...FSSDVPLKLDCV..L.KDD-Y..KQ.Q.ISFETDGDlipKEHPS..IVNCKT.R..AYI.....SDI...R.P..RVE....HPEE........RTE....K...VAA.SG.............HSKRGMTDD.E-RALEE...................ELR..ALLTKKEIYIMNLQ.....EEKNK--.....................--.-.----.------.---...--.--------------..................----...-----..------...-----------.....----------------wrllgeyedvkeklts..............................................................................................................................
GP_RVFVZ/1-95                        .......................MYVLLTIL-TSVLVCE.A...I-IRVSLSST.REETCFGDSTNPEMIEGAW--.DSLREEEMPE-ELSCS--.------------ISGIREV...KTSSQELY----..-.--RAL..KA.I.IAADGLNN...IT---..------.-..---.....---...-.-..---....----........---....-...---.--.............---------.-------...................---..--------------.....-------.....................--.-.----.------.---...--.--------------..................----...-----..------...-----------.....----------------chgkd.........................................................................................................................................
A0A5C0E4I4_9VIRU/2-318               .....flrtvtliallsgadsii----------------.-...-KIFSIHPEG.SSKVCLSNQSPAEVISYYWSL.QMDK--LAKE-NYMCSIG.DSIKENMDVNKIRRLVKQV...GESPTEISFQCQvaDvEKSGM..GV.S.YTFNGIDD..tVPGTH..LVDCDN.G..TKS.....IGVa.rA.T..GPQ....INRLvgpppvlvEVP....R...LEP.KVrgdla..elsrrvS--------.EAKEKEElmtker......ealksqaDLM..QVKSSAKFKELEEQ.....IAELKED....................iID.R.EFEN.NAIKKE.MRA...SE.AESVALREEINGLHeilkleh....eakkemnRSLE...EAKSR..IQS---...-----------.....----------------gynmrnqplraslgntkygvrmttvlpvltafsllsagaia.....................................................................................................
A0A0S1MT47_PTPV/2-270                .......................IFTILNVLTRAMLVMS.M...YSLTTWDSSS.RNDICFSNDSPLEGLVYYWET.HSKKHDYKKQGSQKCRVG.DSDKKMISNVTIISLISEI...QKSISELSLSCG..N.NDNST..GQ.V.LTFNGLED..tIRGDY..IVDCVT.G..LYQ.....SDI...G.V..GVG....LGRIn......hDHQ....Q...VKN.KAv..........viDEKEKMISLlETQQSEN...................DIK..TQVLMSEIEQLKNQ.....LSKRRNE.....................--.R.GQEK.RDAEKL.MSD...LM.ARNSDLRNHNVILT..................DEIS...QIKNN..ITIHRN...RNMMSTTVVPA.....ILSVALLSSSVGPITA..............................................................................................................................................
#=GC seq_cons                        ....................hhh.......h...hhs.s.h...hhlts.psts.psclChSsposhchl.tYW...chpc...hspsshhCpls.su.hphhstpshhphlppl...tpSssthphpC...p.pppsh..th.p.lthsuhss.....tsh..hlsCps.t..phl.....p-l...s.s....p....t.tl........chp....p...hpt.tt.............pthcp.h...csct.pp...................chp..tp.hppchpphppp.....hpc.+tc........................t...cp..thp.h.htp......h.ht...pp...L...................tph....phhpp..hpt......................................tth...........................................................................................................................................
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