#=GF ID RIPR_jelly-roll-like
#=GF AC PF29999.1
#=GF DE RIPR second jelly roll-like domain
#=GF AU Morveli N;0000-0003-2496-881X
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE ECOD:O97302_TED02
#=GF GA 30.20 30.20;
#=GF TC 30.20 31.70;
#=GF NC 30.10 30.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 90746521 --cpu 8 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RC Function description for O97302
#=GF RN [1]
#=GF RM 21909261
#=GF RT "An EGF-like protein forms a complex with PfRh5 and is required
#=GF RT for invasion of human erythrocytes by Plasmodium falciparum.";
#=GF RA Chen L., Lopaticki S., Riglar D.T., Dekiwadia C., Uboldi A.D.,
#=GF RA Tham W.H., O'Neill M.T., Richard D., Baum J., Ralph S.A., Cowman
#=GF RA A.F.;
#=GF RL PLoS Pathog. 7:E1002199-E1002199(2011).
#=GF RC Function description for O97302
#=GF RN [2]
#=GF RM 25583518
#=GF RT "Multiprotein complex between the GPI-anchored CyRPA with PfRH5
#=GF RT and PfRipr is crucial for Plasmodium falciparum erythrocyte
#=GF RT invasion.";
#=GF RA Reddy K.S., Amlabu E., Pandey A.K., Mitra P., Chauhan V.S., Gaur
#=GF RA D.;
#=GF RL Proc. Natl. Acad. Sci. U.S.A. 112:1179-1184(2015).
#=GF RC Function description for O97302
#=GF RN [3]
#=GF RM 27374406
#=GF RT "Essential Role of the PfRh5/PfRipr/CyRPA Complex during
#=GF RT Plasmodium falciparum Invasion of Erythrocytes.";
#=GF RA Volz J.C., Yap A., Sisquella X., Thompson J.K., Lim N.T.,
#=GF RA Whitehead L.W., Chen L., Lampe M., Tham W.H., Wilson D., Nebl
#=GF RA T., Marapana D., Triglia T., Wong W., Rogers K.L., Cowman A.F.;
#=GF RL Cell Host Microbe 20:60-71(2016).
#=GF RC Function description for O97302
#=GF RN [4]
#=GF RM 27692771
#=GF RT "Identification of Plasmodium falciparum reticulocyte binding
#=GF RT protein homologue 5-interacting protein, PfRipr, as a highly
#=GF RT conserved blood-stage malaria vaccine candidate.";
#=GF RA Ntege E.H., Arisue N., Ito D., Hasegawa T., Palacpac N.M.Q.,
#=GF RA Egwang T.G., Horii T., Takashima E., Tsuboi T.;
#=GF RL Vaccine 34:5612-5622(2016).
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This entry represents the a jelly roll-like domain found in the
#=GF CC RH5-interacting protein (RIPR) of Plasmodium species. RIPR is an
#=GF CC essential component of the PfRH5 adhesion complex, which
#=GF CC facilitates merozoite invasion of human erythrocytes [1,2]. The
#=GF CC protein forms a tripartite complex with RH5 and CyRPA at the
#=GF CC merozoite surface during host cell invasion [2,3]. While the
#=GF CC full-length RIPR protein is critical for erythrocyte invasion
#=GF CC and contains multiple EGF-like domains, the specific function of
#=GF CC this domain remains to be determined. This domain is found in
#=GF CC apicomplexan parasites, particularly within the genus
#=GF CC Plasmodium. This domain is next to the N-terminal domain.
#=GF SQ 25
#=GS Q7RSJ8_PLAYO/173-254 AC Q7RSJ8.1
#=GS A0A0L7M7C4_PLAF4/164-245 AC A0A0L7M7C4.1
#=GS A5K7J3_PLAVS/169-252 AC A5K7J3.1
#=GS K6UJP1_PLACD/98-180 AC K6UJP1.1
#=GS A0A1D3TGU7_PLAOA/183-264 AC A0A1D3TGU7.1
#=GS A0A653HE41_9APIC/1-79 AC A0A653HE41.1
#=GS A0A024VWJ5_PLAFA/164-245 AC A0A024VWJ5.1
#=GS W4IRK1_PLAFP/164-245 AC W4IRK1.1
#=GS A0A024WCV4_PLAFA/164-245 AC A0A024WCV4.1
#=GS A0A0L1ID04_PLAFA/164-245 AC A0A0L1ID04.1
#=GS A0A024XED2_PLAFC/164-245 AC A0A024XED2.1
#=GS A0A024WXT8_PLAFA/164-245 AC A0A024WXT8.1
#=GS A0A1A8WBK7_PLAOA/183-264 AC A0A1A8WBK7.1
#=GS A0A1A8YRF9_PLAOA/188-269 AC A0A1A8YRF9.1
#=GS A0A0L0CXG4_PLAFA/159-240 AC A0A0L0CXG4.1
#=GS W7KCI0_PLAFO/164-245 AC W7KCI0.1
#=GS W7JI43_PLAFA/164-245 AC W7JI43.1
#=GS A0A1J1H8F6_PLARL/161-242 AC A0A1J1H8F6.1
#=GS RH5IP_PLAF7/164-245 AC O97302.1
#=GS A0A0L7KDH5_PLAFX/164-245 AC A0A0L7KDH5.1
#=GS A0A8S3TS21_MYTED/9-89 AC A0A8S3TS21.1
#=GS A0A1Y1JEA0_PLAGO/174-257 AC A0A1Y1JEA0.1
#=GS A0A509ANC3_PLABA/170-251 AC A0A509ANC3.1
#=GS A0A384LLB5_PLAKH/166-248 AC A0A384LLB5.1
#=GS A0A1D3PAH2_PLAMA/184-265 AC A0A1D3PAH2.1
Q7RSJ8_PLAYO/173-254 .....................IYQEIiFLENQKKILINCNTMFIDIVSINSIPF..TYCLNDNLLLYGLKLCANKTYCYINFSKFDV-.KSCPIYDS.YILHIKYRCK.
A0A0L7M7C4_PLAF4/164-245 .....................VYEET.FFEKGKNDQINCQGMYISLRSVHVHTH..NAILQQETLTYIKNLCDGKNNCKFDFDSIKYE.NKSLTHYL.FFINIQYQCI.
A5K7J3_PLAVS/169-252 .....................VYEEL.FFQESEKGVISCHAMNINLRYVGIHTSgnNTCIQDYLQEHLKELCNEKKACEIDFKNVKKG.NSCSLENN.FLIHVNYECV.
K6UJP1_PLACD/98-180 .....................VYEEI.FFKDSEKGSISCHAMNISLRYVSINTSgnNNCIQDHLQDYLKNLCNEKKSCEIDFTKVKS-.NGCILGSD.FIIHVKYECV.
A0A1D3TGU7_PLAOA/183-264 .....................IYQEL.FYEKEKKGIINCHGMNINIRSINIHTK..NSCINNYILNHIKELCDDKKYCEIDFDIIKRN.EKCELDEF.FVVSINYEC-e
A0A653HE41_9APIC/1-79 .....................----L.FFANMQKMVINCHSMNILIRSINIYTE..PNCIFNNLTYHIKELCEKKSSCVIDVSSLSIK.NKCDINNRfYFIHINYEC-e
A0A024VWJ5_PLAFA/164-245 .....................VYEET.FFEKGKNDQINCQGMYISLRSAHVHTH..NAILQQETLTYIKNLCDGKNNCKFDFDSIKYE.NKSLTHYL.FFINIQYQCI.
W4IRK1_PLAFP/164-245 .....................VYEET.FFEKGKNDQINCQGMYISLRSVHVHTH..NAILQQETLTYIKNLCDGKNNCKFDFDSIKYE.NKSLTHYL.FFINIQYQCI.
A0A024WCV4_PLAFA/164-245 .....................VYEET.FFEKGKNDQINCQGMYISLRSVHVHTH..NAILQQETLTYIKNLCDGKNNCKFDFDSIKYE.NKSLTHYL.FFINIQYQCI.
A0A0L1ID04_PLAFA/164-245 .....................VYEET.FFEKGKNDQINCQGMYISLRSVHVHTH..NAILQQETLTYIKNLCDGKNNCKFDFDSIKYE.NKSLTHYL.FFINIQYQCI.
A0A024XED2_PLAFC/164-245 .....................VYEET.FFEKGKNDQINCQGMYISLRSVHVHTH..NAILQQETLTYIKNLCDGKNNCKFDFDSIKYE.NKSLTHYL.FFINIQYQCI.
A0A024WXT8_PLAFA/164-245 .....................VYEET.FFEKGKNDQINCQGMYISLRSVHVHTH..NAILQQETLTYIKNLCDGKNNCKFDFDSIKYE.NKSLTHYL.FFINIQYQCI.
A0A1A8WBK7_PLAOA/183-264 .....................IYQEL.FYEKEKKGIINCHGMNINIRSINIHTK..NSCINNYILNHIKELCDDKKYCEIDFDIIKRN.EKCELDEF.FVVSINYEC-e
A0A1A8YRF9_PLAOA/188-269 .....................IYQEL.FYEKEKKGIINCHSMNINIRSINIHTK..NSCINNYILNHIKELCDDKKYCEIDFDIIKRN.EKCELDEF.FLVSINYEC-e
A0A0L0CXG4_PLAFA/159-240 .....................VYEET.FFEKGKNDQINCQGMYISLRSAHVHTH..NAILQQETLTYIKNLCDGKNNCKFDFDSIKYE.NKSLTHYL.FFINIQYQCI.
W7KCI0_PLAFO/164-245 .....................VYEET.FFEKGKNDQINCQGMYISLRSVHVHTH..NAILQQETLTYIKNLCDGKNNCKFDFDSIKYE.NKSLTHYL.FFINIQYQCI.
W7JI43_PLAFA/164-245 .....................VYEET.FFEKGKNDQINCQGMYISLRSVHVHTH..NAILQQETLTYIKNLCDGKNNCKFDFDSIKYE.NKSLTHYL.FFINIQYQCI.
A0A1J1H8F6_PLARL/161-242 .....................VFQEL.FFEKEKKGILDCHGLTIDIRLINIHTQ..HGCLQDKLLNNIMSECNEKSHCEIIFSNVDKS.SKCLTAHS.FFVSIYYECK.
RH5IP_PLAF7/164-245 .....................VYEET.FFEKGKNDQINCQGMYISLRSVHVHTH..NAILQQETLTYIKNLCDGKNNCKFDFDSIKYE.NKSLTHYL.FFINIQYQCI.
A0A0L7KDH5_PLAFX/164-245 .....................VYEET.FFEKGKNDQINCQGMYISLRSVHVHTH..NAILQQETLTYIKNLCDGKNNCKFDFDSIKYE.NKSLTHYL.FFINIQYQCI.
A0A8S3TS21_MYTED/9-89 ivktytegerahlacsvefke-----.---------------IIDITSINYF-N..DTCIHSETY-GIGNLCNGKTNCSFDVSNSNIG.SSCGANGT.AMFKVEYNCI.
A0A1Y1JEA0_PLAGO/174-257 .....................IYEDI.FFKENEKGIITCHAMKINLRYISIHTF.dKKCLQDVFEEHVRAKCNERKTCEIDFKNIKTGkKKCVLGKD.FIVHIKYECI.
A0A509ANC3_PLABA/170-251 .....................VYQEIvFLENKKKILINCNTMFVDIISINSIPS..KYCLNDYLLLYGLKLCTNKTYCHIDFSKFNV-.NSCPINDS.YILHIKYKCK.
A0A384LLB5_PLAKH/166-248 ....................m-YQEI.FFQESEKGVINCHGMDISLRYVGIHTNgnNNCIQDYLHDHLKNLCNGKKLCEIDFKMVKH-.EKCILGSN.FLIHVNYECV.
A0A1D3PAH2_PLAMA/184-265 .....................TYENI.FFEKDKKGIINCYAMDIDIRYVHVYAT..NECVHNYFLEYIKEACQGKKYCELDFTTIKNG.ENCPMSKN.IFITVQYTCV.
#=GC seq_cons .....................VYEEh.FFEKuKps.INCpGMhIsLRSlplHT+..NuhLQpchLsYIKNLCDGKssCchDFDsIKhp.NKslhchh.FFIsIpYpCl.
//
