#=GF ID RNA_ligase
#=GF AC PF09414.14
#=GF DE RNA ligase
#=GF AU Mistry J;0000-0003-2479-5322
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE pdb_2hvq
#=GF GA 27.00 27.00;
#=GF TC 27.00 27.00;
#=GF NC 26.90 26.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF CL CL0179
#=GF RN [1]
#=GF RM 17018278
#=GF RT RNA ligase structures reveal the basis for RNA specificity and
#=GF RT conformational changes that drive ligation forward.
#=GF RA Nandakumar J, Shuman S, Lima CD;
#=GF RL Cell. 2006;127:71-84.
#=GF DR INTERPRO; IPR021122;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This is a family of RNA ligases. The enzyme repairs RNA strand
#=GF CC breaks in nicked DNA:RNA and RNA:RNA but not in DNA:DNA
#=GF CC duplexes.
#=GF SQ 2166
#=GS A0A495XQ85_9PSEU/33-182 AC A0A495XQ85.1
#=GS A0A1W1VN79_9DEIO/33-183 AC A0A1W1VN79.1
#=GS L9WG58_9EURY/82-240 AC L9WG58.1
#=GS A0A2C9CXB7_9CAUD/202-407 AC A0A2C9CXB7.1
#=GS A0A559KCJ3_9BACL/23-196 AC A0A559KCJ3.1
#=GS A0A149VVI1_9PROT/38-202 AC A0A149VVI1.1
#=GS A0A833T461_PHYIN/387-567 AC A0A833T461.1
#=GS A0A1C4RQL5_9ACTN/5-209 AC A0A1C4RQL5.1
#=GS A0A1X4ISW7_9RHOB/32-183 AC A0A1X4ISW7.1
#=GS E3RJH4_PYRTT/46-247 AC E3RJH4.1
#=GS A0A401Z7F6_9CHLR/152-327 AC A0A401Z7F6.1
#=GS A0A1W6JU10_9CAUD/28-228 AC A0A1W6JU10.1
#=GS A0A0M6ZQI2_9HYPH/34-226 AC A0A0M6ZQI2.1
#=GS A0A1H7WZY3_9ACTN/21-213 AC A0A1H7WZY3.1
#=GS A0A1E1KF97_9HELO/220-421 AC A0A1E1KF97.1
#=GS A0A6J4D1F8_9CAUD/28-205 AC A0A6J4D1F8.1
#=GS A0A850J866_9ACTN/34-226 AC A0A850J866.1
#=GS A0A285T794_9RHOB/33-184 AC A0A285T794.1
#=GS A0A4Q4W6N0_9PEZI/58-253 AC A0A4Q4W6N0.1
#=GS B2WII2_PYRTR/46-247 AC B2WII2.1
#=GS A0A8J3Y7E9_9ACTN/45-252 AC A0A8J3Y7E9.1
#=GS A0A3Q9R9G4_9CAUD/28-227 AC A0A3Q9R9G4.1
#=GS O27289_METTH/90-248 AC O27289.1
#=GS A0A7M5V7K1_9CNID/32-246 AC A0A7M5V7K1.1
#=GS W7LFS1_GIBM7/153-242 AC W7LFS1.1
#=GS A0A0U5AFW3_9BACT/72-230 AC A0A0U5AFW3.1
#=GS A0A835VRV3_CHLIN/5-225 AC A0A835VRV3.1
#=GS E4NUP9_HALBP/21-192 AC E4NUP9.1
#=GS A0A101JLU7_9ACTN/45-254 AC A0A101JLU7.1
#=GS A0A0K1PIS1_9DELT/17-169 AC A0A0K1PIS1.1
#=GS A0A1E5PMV7_9ACTN/26-242 AC A0A1E5PMV7.1
#=GS A0A5C1AG94_9BACT/16-187 AC A0A5C1AG94.1
#=GS A0A0D2MKB3_9CHLO/298-463 AC A0A0D2MKB3.1
#=GS A0A850ESR1_9BACL/33-187 AC A0A850ESR1.1
#=GS A0A4S2N7Q0_9PEZI/455-629 AC A0A4S2N7Q0.1
#=GS A0A1Q5GN84_9ACTN/33-185 AC A0A1Q5GN84.1
#=GS A0A561UN54_9ACTN/33-186 AC A0A561UN54.1
#=GS I4AJT6_BERLS/56-223 AC I4AJT6.1
#=GS A0A2W2GP62_9ACTN/43-247 AC A0A2W2GP62.1
#=GS A0A3N4J2K8_9PEZI/24-221 AC A0A3N4J2K8.1
#=GS A0A238V4X2_9ACTN/31-183 AC A0A238V4X2.1
#=GS A0A2P6NJU3_9EUKA/181-351 AC A0A2P6NJU3.1
#=GS A0A2Z4PZ07_9CAUD/20-189 AC A0A2Z4PZ07.1
#=GS Q3JB94_NITOC/76-232 AC Q3JB94.1
#=GS A0A6C1BYS9_9AQUI/70-226 AC A0A6C1BYS9.1
#=GS B3FJL6_BP201/202-454 AC B3FJL6.1
#=GS A0A2A3HZ75_9ACTN/158-341 AC A0A2A3HZ75.1
#=GS A0A7W5FCH0_9ACTN/30-182 AC A0A7W5FCH0.1
#=GS F0SGW1_RUBBR/41-239 AC F0SGW1.1
#=GS R4T716_9CAUD/22-204 AC R4T716.1
#=GS Q6D569_PECAS/40-233 AC Q6D569.1
#=GS A0A317NDU3_9GAMM/38-202 AC A0A317NDU3.1
#=GS A0A1Z4JXF4_9CYAN/39-243 AC A0A1Z4JXF4.1
#=GS A0A433PJ65_9FUNG/36-235 AC A0A433PJ65.1
#=GS A0A4S2T4I6_9ACTN/33-182 AC A0A4S2T4I6.1
#=GS Y414_METJA/93-253 AC Q57857.1
#=GS K9RGE4_9CYAN/31-236 AC K9RGE4.1
#=GS A0A6N1NMK5_9VIRU/37-235 AC A0A6N1NMK5.1
#=GS A0A6A5BMS6_NAEFO/42-305 AC A0A6A5BMS6.1
#=GS F2R9Y2_STRVP/158-342 AC F2R9Y2.1
#=GS A0A1U7NRZ3_9DEIO/33-183 AC A0A1U7NRZ3.1
#=GS A0A101QWA8_9ACTN/158-341 AC A0A101QWA8.1
#=GS A0A2S1GLS6_9CAUD/29-228 AC A0A2S1GLS6.1
#=GS A0A2D3UCH1_STRC0/33-183 AC A0A2D3UCH1.1
#=GS D0NDH6_PHYIT/419-459 AC D0NDH6.1
#=GS A0A0G3UTS3_9ACTN/34-183 AC A0A0G3UTS3.1
#=GS A0A218QKQ3_9CYAN/34-237 AC A0A218QKQ3.1
#=GS A0A2Z5R0Y7_9MICC/41-232 AC A0A2Z5R0Y7.1
#=GS A0A2U9NYT1_STRAS/158-342 AC A0A2U9NYT1.1
#=GS A0A7L4XZI5_9ACTN/158-342 AC A0A7L4XZI5.1
#=GS A0A7G6YV84_9BACT/9-170 AC A0A7G6YV84.1
#=GS A0A125STA1_9CAUD/47-238 AC A0A125STA1.1
#=GS A0A4Z0HBV1_9ACTN/33-236 AC A0A4Z0HBV1.1
#=GS K9VR16_9CYAN/20-195 AC K9VR16.1
#=GS A0A6M5YMV4_9BACT/36-228 AC A0A6M5YMV4.1
#=GS A0A8H7THY9_9HELO/204-405 AC A0A8H7THY9.1
#=GS A0A2U7UAP0_9VIRU/29-206 AC A0A2U7UAP0.1
#=GS A0A8B6E1R5_MYTGA/127-365 AC A0A8B6E1R5.1
#=GS A0A345MNE7_9CAUD/162-314 AC A0A345MNE7.1
#=GS R6FN78_9BACE/36-217 AC R6FN78.1
#=GS A0A1E3L3R6_9BACL/26-185 AC A0A1E3L3R6.1
#=GS A0A1Y6IWC7_9VIBR/33-183 AC A0A1Y6IWC7.1
#=GS A0A518BAK1_9BACT/41-234 AC A0A518BAK1.1
#=GS A0A1N6UMC1_9EURY/45-214 AC A0A1N6UMC1.1
#=GS A0A5C5ZX23_9BACT/159-322 AC A0A5C5ZX23.1
#=GS A0A4Q9I0G7_STRKA/33-237 AC A0A4Q9I0G7.1
#=GS A0A2L1GRI2_9DELT/23-185 AC A0A2L1GRI2.1
#=GS A0A317SHJ0_9PEZI/572-740 AC A0A317SHJ0.1
#=GS A0A1H7K442_9FLAO/29-224 AC A0A1H7K442.1
#=GS A0A5B9PKL7_9BACT/41-213 AC A0A5B9PKL7.1
#=GS R8BCV0_PHAM7/189-375 AC R8BCV0.1
#=GS V5ASZ3_TRYCR/50-271 AC V5ASZ3.1
#=GS A0A255SXV5_9BACT/91-289 AC A0A255SXV5.1
#=GS A0A2T3AK68_9PEZI/108-295 AC A0A2T3AK68.1
#=GS A0A0M8SSE2_9ACTN/41-240 AC A0A0M8SSE2.1
#=GS A0A347UD69_9RHOB/35-226 AC A0A347UD69.1
#=GS A0A1I0BGI7_9FIRM/23-195 AC A0A1I0BGI7.1
#=GS V5DD75_TRYCR/110-338 AC V5DD75.1
#=GS A0A1H4PUW1_9ACTN/158-341 AC A0A1H4PUW1.1
#=GS A0A151Z4I4_TIELA/240-415 AC A0A151Z4I4.1
#=GS D3SL17_THEAH/70-226 AC D3SL17.1
#=GS I0K1D2_METFB/69-226 AC I0K1D2.1
#=GS Q56EF5_9CAUD/170-356 AC Q56EF5.1
#=GS A0A8J7ZQW7_9EURY/75-229 AC A0A8J7ZQW7.1
#=GS L9ZLZ0_9EURY/82-241 AC L9ZLZ0.1
#=GS RLIG2_BPT4/28-227 AC P32277.1
#=GS A0A2T6ZGV0_TUBBO/715-893 AC A0A2T6ZGV0.1
#=GS A0A1H1FZ60_9EURY/82-237 AC A0A1H1FZ60.1
#=GS L1KQV0_9ACTN/33-183 AC L1KQV0.1
#=GS A0A8H4X6F5_9HYPO/178-361 AC A0A8H4X6F5.1
#=GS A0A3N1Y6Z5_9GAMM/73-229 AC A0A3N1Y6Z5.1
#=GS A0A7Y0HUF3_9BIFI/177-343 AC A0A7Y0HUF3.1
#=GS A0A1V9ZIM2_9STRA/43-234 AC A0A1V9ZIM2.1
#=GS A0A812I5A4_9DINO/367-533 AC A0A812I5A4.1
#=GS F0T8D9_METLA/114-271 AC F0T8D9.1
#=GS A0A2T4VNZ9_VITXG/27-222 AC A0A2T4VNZ9.1
#=GS A0A2Z3H202_9BACT/36-228 AC A0A2Z3H202.1
#=GS L8WRT3_THACA/801-972 AC L8WRT3.1
#=GS D2V981_NAEGR/48-278 AC D2V981.1
#=GS A0A542QRC3_9ACTN/63-213 AC A0A542QRC3.1
#=GS A9UPG1_MONBE/128-296 AC A9UPG1.1
#=GS T0R8M0_SAPDV/137-303 AC T0R8M0.1
#=GS A0A2T0SD90_9ACTN/35-187 AC A0A2T0SD90.1
#=GS A0A1S6UAE4_9CAUD/204-410 AC A0A1S6UAE4.1
#=GS A0A240F2U3_9CAUD/170-356 AC A0A240F2U3.1
#=GS A0A523QBN9_9BURK/46-239 AC A0A523QBN9.1
#=GS A0A238J9V1_9RHOB/34-226 AC A0A238J9V1.1
#=GS J7L603_NOCAA/158-346 AC J7L603.1
#=GS A0A8A3P9X4_9HELO/38-239 AC A0A8A3P9X4.1
#=GS A0A2P1EKY1_9VIRU/20-198 AC A0A2P1EKY1.1
#=GS A0A2T0SZE1_9PSEU/170-342 AC A0A2T0SZE1.1
#=GS A0A423WKZ1_9PEZI/184-372 AC A0A423WKZ1.1
#=GS I1RAP8_GIBZE/177-360 AC I1RAP8.1
#=GS A0A7W8A862_9ACTN/56-255 AC A0A7W8A862.1
#=GS A0A0B4E3A0_9RHOB/36-187 AC A0A0B4E3A0.1
#=GS A0A395N055_9HYPO/175-358 AC A0A395N055.1
#=GS A0A318USW0_9SPHI/57-186 AC A0A318USW0.1
#=GS A0A6G6XKW7_9CAUD/191-431 AC A0A6G6XKW7.1
#=GS A0A1J4NXT8_9ACTN/158-341 AC A0A1J4NXT8.1
#=GS A0A6G8T572_9EURY/77-233 AC A0A6G8T572.1
#=GS A0A075DXU3_9CAUD/31-263 AC A0A075DXU3.1
#=GS A0A143FJA6_9CAUD/29-193 AC A0A143FJA6.1
#=GS M0CCG5_9EURY/82-238 AC M0CCG5.1
#=GS A0A1Y1R5Z4_9GAMM/39-202 AC A0A1Y1R5Z4.1
#=GS A0A7K0D7C7_9NOCA/158-349 AC A0A7K0D7C7.1
#=GS G2QYB6_THETT/141-330 AC G2QYB6.1
#=GS W7SYW6_9PSEU/40-246 AC W7SYW6.1
#=GS A0A7W3MTK6_9ACTN/18-219 AC A0A7W3MTK6.1
#=GS A0A7Y8X3E4_9ACTN/33-182 AC A0A7Y8X3E4.1
#=GS A0A7L8ZPM7_9CAUD/204-409 AC A0A7L8ZPM7.1
#=GS A0A1X0NW43_9TRYP/50-271 AC A0A1X0NW43.1
#=GS A0A1Y3P150_PIRSE/34-204 AC A0A1Y3P150.1
#=GS Q0IL51_NPVLS/254-433 AC Q0IL51.1
#=GS A0A1H4XSP3_9ACTN/158-341 AC A0A1H4XSP3.1
#=GS A0A0D7K9Q5_9BURK/38-202 AC A0A0D7K9Q5.1
#=GS A0A1S2K0Y6_9ACTN/33-183 AC A0A1S2K0Y6.1
#=GS B2ACJ5_PODAN/277-484 AC B2ACJ5.1
#=GS A0A817N709_9BILA/38-254 AC A0A817N709.1
#=GS A0A4P9VRL8_9GAMM/39-189 AC A0A4P9VRL8.1
#=GS A0A8J3IKM8_9CHLR/36-229 AC A0A8J3IKM8.1
#=GS A0A517ZQA7_9PLAN/41-238 AC A0A517ZQA7.1
#=GS Q828Q7_STRAW/158-341 AC Q828Q7.1
#=GS A0A0A6P7R9_9GAMM/60-224 AC A0A0A6P7R9.2
#=GS L8HFI2_ACACA/43-231 AC L8HFI2.1
#=GS A0A1M7J5K9_9BACT/152-326 AC A0A1M7J5K9.1
#=GS A0A081C3S0_9BACT/37-190 AC A0A081C3S0.1
#=GS D9VMW7_9ACTN/33-182 AC D9VMW7.1
#=GS A0A0B4ZZL5_9CAUD/2-125 AC A0A0B4ZZL5.1
#=GS A0A1H7YA03_9FIRM/164-338 AC A0A1H7YA03.1
#=GS A0A2H3HVB2_FUSOX/177-360 AC A0A2H3HVB2.1
#=GS A0A818LLG6_9BILA/30-237 AC A0A818LLG6.1
#=GS A0A0M8W5C0_9NOCA/34-226 AC A0A0M8W5C0.1
#=GS A0A1Q5E173_9ACTN/33-182 AC A0A1Q5E173.1
#=GS A0A291I9M2_9CAUD/34-210 AC A0A291I9M2.1
#=GS A0A2H4YG17_9CAUD/29-223 AC A0A2H4YG17.1
#=GS A0A221SYH7_9DEIO/34-184 AC A0A221SYH7.1
#=GS A0A345L4N3_9CAUD/190-425 AC A0A345L4N3.1
#=GS A0A5M3XAC8_9ACTN/33-182 AC A0A5M3XAC8.1
#=GS A0A5D0PLF8_9ACTN/22-117 AC A0A5D0PLF8.1
#=GS A0A8H4ASJ3_GIGMA/58-166 AC A0A8H4ASJ3.1
#=GS A0A346YSH3_9HYPH/32-183 AC A0A346YSH3.1
#=GS A0A428PWX8_9HYPO/175-316 AC A0A428PWX8.1
#=GS A0A813A4U3_9DINO/22-176 AC A0A813A4U3.1
#=GS A0A366DPY1_9NOCA/188-404 AC A0A366DPY1.1
#=GS A0A4R4QUL0_9ACTN/51-259 AC A0A4R4QUL0.1
#=GS A0A024B0Q2_9CAUD/28-191 AC A0A024B0Q2.1
#=GS A0A498G4S6_9EURY/81-239 AC A0A498G4S6.1
#=GS A0A075AVU8_ROZAC/38-235 AC A0A075AVU8.1
#=GS A0A0K1LMT7_9CAUD/29-226 AC A0A0K1LMT7.1
#=GS A0A550I5A7_9ACTN/158-341 AC A0A550I5A7.1
#=GS A0A448Z302_9STRA/514-708 AC A0A448Z302.1
#=GS Q30KZ0_9CAUD/22-202 AC Q30KZ0.1
#=GS A0A495IZ39_9SPHI/37-205 AC A0A495IZ39.1
#=GS D3E2W5_METRM/202-389 AC D3E2W5.1
#=GS W7BAS7_9LIST/31-190 AC W7BAS7.1
#=GS A0A8J3RRL7_9ACTN/33-182 AC A0A8J3RRL7.1
#=GS A2BN10_HYPBU/93-251 AC A2BN10.1
#=GS A0A649VNI5_9CAUD/576-777 AC A0A649VNI5.1
#=GS A0A821DEF6_9BILA/32-252 AC A0A821DEF6.1
#=GS A0A1I1X5L7_9ACTN/158-342 AC A0A1I1X5L7.1
#=GS A0A8H6XVU4_9AGAR/652-801 AC A0A8H6XVU4.1
#=GS A0A0U3QVJ4_9ACTN/158-341 AC A0A0U3QVJ4.1
#=GS A0A5N5QP35_9AGAM/785-956 AC A0A5N5QP35.1
#=GS D7AU87_NOCDD/45-252 AC D7AU87.1
#=GS A6G6B3_9DELT/38-188 AC A6G6B3.1
#=GS A0A2Z5H9N0_9CAUD/190-425 AC A0A2Z5H9N0.1
#=GS F4Q603_CAVFA/268-445 AC F4Q603.1
#=GS A0A1I5JJS2_9ACTN/34-226 AC A0A1I5JJS2.1
#=GS D0LWQ3_HALO1/37-232 AC D0LWQ3.1
#=GS A0A813PGQ8_ADIRI/30-236 AC A0A813PGQ8.1
#=GS K9WBH4_9CYAN/37-242 AC K9WBH4.1
#=GS A0A0D8ZS85_9CYAN/151-315 AC A0A0D8ZS85.1
#=GS Q6T452_LEIMA/51-272 AC Q6T452.1
#=GS A0A2M8H195_9VIBR/33-183 AC A0A2M8H195.1
#=GS K9U961_CHAP6/16-193 AC K9U961.1
#=GS A0A835XJA0_9CHLO/39-215 AC A0A835XJA0.1
#=GS A0A7K2YQG6_9ACTN/158-348 AC A0A7K2YQG6.1
#=GS F7VUB1_SORMK/388-580 AC F7VUB1.1
#=GS A0A423VZW1_9PEZI/197-389 AC A0A423VZW1.1
#=GS A0A1C7HIM5_9BURK/17-204 AC A0A1C7HIM5.2
#=GS A0A814S1G8_9BILA/30-236 AC A0A814S1G8.1
#=GS A0A8J7DZP6_9CYAN/15-180 AC A0A8J7DZP6.1
#=GS A0A5B0FIH4_9BACT/32-231 AC A0A5B0FIH4.1
#=GS A0A4E0QQ81_9EURY/92-248 AC A0A4E0QQ81.1
#=GS F8C5T4_THEGP/93-251 AC F8C5T4.1
#=GS A0A2H5AXT8_9ACTN/40-248 AC A0A2H5AXT8.1
#=GS D7AXW3_NOCDD/33-225 AC D7AXW3.1
#=GS A0A0B7FPW1_THACB/799-970 AC A0A0B7FPW1.1
#=GS A0A679DKE1_9CAUD/29-233 AC A0A679DKE1.1
#=GS A0A455X326_9PROT/39-202 AC A0A455X326.1
#=GS A0A848LTN8_9DELT/151-323 AC A0A848LTN8.1
#=GS Q5JDI7_THEKO/85-240 AC Q5JDI7.1
#=GS A0A1I5YDU4_9FIRM/164-338 AC A0A1I5YDU4.1
#=GS A0A7M5UWG5_9CNID/32-243 AC A0A7M5UWG5.1
#=GS A0A5C3KMV9_9AGAR/682-854 AC A0A5C3KMV9.1
#=GS R4T9D4_9CAUD/146-331 AC R4T9D4.1
#=GS A0A1Z4L7H5_NOSLI/36-228 AC A0A1Z4L7H5.1
#=GS A0A4U1J075_9DELT/36-240 AC A0A4U1J075.1
#=GS U2YXE5_9EURY/23-236 AC U2YXE5.1
#=GS A0A1Q9EVM9_SYMMI/529-695 AC A0A1Q9EVM9.1
#=GS A0A813ZE87_9BILA/377-547 AC A0A813ZE87.1
#=GS A0A171DQN0_9ACTN/22-214 AC A0A171DQN0.1
#=GS A0A078APN9_STYLE/176-370 AC A0A078APN9.1
#=GS E8U8X1_DEIML/40-200 AC E8U8X1.1
#=GS A0A410T850_9CAUD/179-374 AC A0A410T850.1
#=GS A0A8J8GWM4_9ACTN/33-225 AC A0A8J8GWM4.1
#=GS A0A364Y9R9_9BACT/36-203 AC A0A364Y9R9.1
#=GS A0A816TG55_9BILA/30-237 AC A0A816TG55.1
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