#=GF ID   Response_reg_2
#=GF AC   PF19192.3
#=GF DE   Response receiver domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Bellieny-Rabelo D;0000-0003-2544-7899
#=GF SE   Daniel Bellieny-Rabelo
#=GF GA   27.00 27.00;
#=GF TC   27.40 27.10;
#=GF NC   26.60 26.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0304
#=GF RN   [1]
#=GF RM   19575571
#=GF RT   Biological insights from structures of two-component proteins.
#=GF RA   Gao R, Stock AM;
#=GF RL   Annu Rev Microbiol. 2009;63:133-154.
#=GF RN   [2]
#=GF RM   20951027
#=GF RT   The mechanism of signal transduction by two-component systems.
#=GF RA   Casino P, Rubio V, Marina A;
#=GF RL   Curr Opin Struct Biol. 2010;20:763-771.
#=GF DR   INTERPRO; IPR043834;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a receiver domain (REC) commonly found in the same
#=GF CC   gene-neighbourhood of its cognate HK. Together they comprise a
#=GF CC   Two-Component System (TCS). There is a high degree of
#=GF CC   specificity among REC and DHp domains in a cognate pair. This
#=GF CC   domain is related to the Response_reg (Pfam:PF00072) domain. We
#=GF CC   found that Pfam:PF19191 and this domain show high degree of
#=GF CC   linkage in the same gene-neighbourhoods across several bacterial
#=GF CC   lineages. This implies that they comprise a TCS.
#=GF SQ   71
#=GS A0A2H1E9G3_9FLAO/14-171  AC A0A2H1E9G3.1
#=GS F9ZBK0_ODOSD/14-166      AC F9ZBK0.1
#=GS A0A1Y5KET2_9BACL/16-224  AC A0A1Y5KET2.1
#=GS A0A6H9WQW5_9MICO/16-204  AC A0A6H9WQW5.1
#=GS A0A1B3MBT0_9RHIZ/18-184  AC A0A1B3MBT0.1
#=GS A0A1M6P3Z7_9FLAO/14-173  AC A0A1M6P3Z7.1
#=GS A0A502BNZ5_9RHIZ/17-189  AC A0A502BNZ5.1
#=GS A0A0A8WLM1_9DELT/18-212  AC A0A0A8WLM1.1
#=GS A0A1G7BUG9_9FLAO/14-172  AC A0A1G7BUG9.1
#=GS H2CGF8_9LEPT/16-172      AC H2CGF8.1
#=GS N2A448_9FIRM/16-187      AC N2A448.1
#=GS G3IZQ8_METTV/23-190      AC G3IZQ8.1
#=GS A0A2S8WAZ6_9CAUL/17-176  AC A0A2S8WAZ6.1
#=GS A0A1B5FPH1_9CAUD/18-176  AC A0A1B5FPH1.1
#=GS A0A1W2EGB8_9SPHI/14-166  AC A0A1W2EGB8.1
#=GS A0A1U9Z2M5_9RHIZ/15-196  AC A0A1U9Z2M5.1
#=GS Q26DP9_FLABB/14-169      AC Q26DP9.1
#=GS D4E4H6_SEROD/15-187      AC D4E4H6.1
#=GS A0A5R8Y7R1_9RHIZ/14-197  AC A0A5R8Y7R1.1
#=GS A0A174GCD9_9BACE/14-169  AC A0A174GCD9.1
#=GS A0A1X1MR03_9VIBR/15-201  AC A0A1X1MR03.1
#=GS A0A0M7ASZ6_9RHOB/14-270  AC A0A0M7ASZ6.1
#=GS A0A3N2KPE2_9BACT/14-169  AC A0A3N2KPE2.1
#=GS A0A4R5CBT3_9FLAO/16-181  AC A0A4R5CBT3.1
#=GS A0A4Q2ZNS6_9SPHI/16-183  AC A0A4Q2ZNS6.1
#=GS A0A1C3EK79_9GAMM/18-153  AC A0A1C3EK79.1
#=GS A0A4S4BI42_9BACL/14-195  AC A0A4S4BI42.1
#=GS A0A6L6UCM9_9FLAO/14-168  AC A0A6L6UCM9.1
#=GS E8T9T5_MESCW/17-185      AC E8T9T5.1
#=GS A0A4Y9PSQ1_9ACTN/14-219  AC A0A4Y9PSQ1.1
#=GS A0A143B5B0_9DELT/25-220  AC A0A143B5B0.1
#=GS A0A068QNR3_9GAMM/23-186  AC A0A068QNR3.1
#=GS A0A6N0WTL3_9SPHN/22-169  AC A0A6N0WTL3.1
#=GS A0A2W2ANK7_9BACT/15-182  AC A0A2W2ANK7.1
#=GS A0A562VIR5_9DELT/24-229  AC A0A562VIR5.1
#=GS A0A1R4HYG2_9GAMM/33-218  AC A0A1R4HYG2.1
#=GS Q1NVW9_9DELT/15-225      AC Q1NVW9.1
#=GS A0A2M9CM51_9MICO/14-208  AC A0A2M9CM51.1
#=GS A0A073ITG9_9RHOB/1-86    AC A0A073ITG9.1
#=GS Q72B88_DESVH/18-213      AC Q72B88.1
#=GS A0A2S9Q7Y7_9RHIZ/21-171  AC A0A2S9Q7Y7.1
#=GS A0A4U1IEK0_9DELT/19-201  AC A0A4U1IEK0.1
#=GS A0A0M2VEQ7_9GAMM/15-199  AC A0A0M2VEQ7.1
#=GS B3EB44_GEOLS/16-180      AC B3EB44.1
#=GS A0A1M6J3V4_9BACT/23-222  AC A0A1M6J3V4.1
#=GS A0A401FRK9_9DELT/22-230  AC A0A401FRK9.1
#=GS A0A1G6U5J1_9PROT/24-252  AC A0A1G6U5J1.1
#=GS A0A0G8ARU6_9SYNE/18-196  AC A0A0G8ARU6.1
#=GS F8X1T6_9BACT/17-168      AC F8X1T6.1
#=GS A9DFR1_HOEPD/26-191      AC A9DFR1.1
#=GS A0A1I7NAV2_9RHIZ/15-216  AC A0A1I7NAV2.1
#=GS A0A229US92_9BACL/16-224  AC A0A229US92.1
#=GS A0A6I5YGQ0_9SPHN/22-169  AC A0A6I5YGQ0.1
#=GS B2VED8_ERWT9/18-103      AC B2VED8.1
#=GS A0A6F8PTC5_9GAMM/16-219  AC A0A6F8PTC5.1
#=GS A0A2V4MLB4_9RHOB/14-197  AC A0A2V4MLB4.1
#=GS A0A5Q0BI77_9GAMM/1-59    AC A0A5Q0BI77.1
#=GS A1BCM1_CHLPD/22-219      AC A1BCM1.1
#=GS A0A1H8XA45_9SPHI/34-187  AC A0A1H8XA45.1
#=GS A0A2H5AUB7_9ACTN/14-210  AC A0A2H5AUB7.1
#=GS I2B9G7_SHIBC/20-208      AC I2B9G7.1
#=GS A0A5C8JFG5_9BACT/19-222  AC A0A5C8JFG5.1
#=GS T2GB31_DESGG/15-188      AC T2GB31.1
#=GS A0A2G8DX51_9GAMM/18-176  AC A0A2G8DX51.1
#=GS A0A084A0Z1_9GAMM/17-216  AC A0A084A0Z1.1
#=GS A0A1M6C629_9BACT/15-170  AC A0A1M6C629.1
#=GS N0E0J6_9MICO/16-204      AC N0E0J6.1
#=GS A0A3S2V3B0_9RHIZ/17-170  AC A0A3S2V3B0.1
#=GS A0A1V0PYV6_9RHOB/18-209  AC A0A1V0PYV6.1
#=GS A0A081NMD5_9GAMM/15-203  AC A0A081NMD5.1
#=GS F9RCY2_VIBSN/15-186      AC F9RCY2.1
A0A2H1E9G3_9FLAO/14-171             .......................................................SIKSAIFIDEKALEPYKA...KPKDPYP------...........................------.........-----.....................................................................EVDLSINLLKKFKEKGIS..LAV..----HKFTPNDLQN..........EERLKYFFKRRDLVLLDWRL.EGND...................gEEHSLNLLSKIVKEK.----....-HIHF...CSIFTS.....EL..NMNE..IIDNVSTYFSGy.nLGYYQ.NIIDELDIYRDDNLATFNQISFNDEK--an...................................
F9ZBK0_ODOSD/14-166                 ......................................................a-IQSAVCIDDQYQEPYQT...TSGKESL------...........................------.........-----.....................................................................NIEFPACLYRSFRVNG-K..CDLdiYNFKG-Y-DTFLE-..........--DQEYLFNNKELLILDWEL.DPESq.................vkYTDALKVLQKAVECD.----....-YVQF...VTLYTQ.....EE..NINN..IAGQVFSYFRN...FGTAE.EQEKKLEGLIEKTD--------------kflkeiesd............................
A0A1Y5KET2_9BACL/16-224             .......................................................YFKDILYVDDAIKKPSDL...KSIMDLANKESAAasetansiqeq....pitrrpvsfsvaS-----.........----Dvnqtnteqqeei.............................................kqsiletngmldDYFDAFEIIYNLNSNGNK..VSP..FFFEG---DHQVET..........---VVSLIEQSHLTILDWEL.DQTG....................GETTLNILESVFRNT.----....GRLKL...LVIYTK.....NP..LQASkmIRDKFASKIVD...--YTQ.THVEESTVDIFDLHDAFVLVCKKREL--ps...................................
A0A6H9WQW5_9MICO/16-204             .......................................................FLQTILMIDDEAFRRETE...ATL-PTDENWDEV...........................E-----.........----Dasigsplkl...................................................ippsgsvegDELDVQEVSRSFAEEALA..CAI..LSPQSLQENEDFRP..........--AFVGTAKRADALILDWNL.NSDN....................GTTAEKLIKAVLHNDtKLPR....RRLRL...LTVYTG.....EP..DLTQ..IAERVAKATTE..sLGEDE.LKWDDDRRVAFSRGPLRVAVFAKEHV--rs...................................
A0A1B3MBT0_9RHIZ/18-184             ......................................................p-IRSVLIIDDDYPTWEEI...LDRKSLV-----Gi.........................cETVATP........nPES-Ksw.................................................................lkQPGPVLELIKKFRQKKPG..LMI.dIYDGAKASDTDEDV..........---LASHLHQSDMLILDYQL.NGDKg..................dGKKSRSIAHALLENR.----....-HFNL...VVIHTK.....AD..DLAV..-----------...-----.----------------------------pfnemvlsllapcahlkdkqsqideaaarikayd...
A0A1M6P3Z7_9FLAO/14-173             ......................................................n-IKSAIYIDENAREFNQD...VAALIGAD-----...........................------.........-----.....................................................................EEILSLELYSKFRSAGVS..LES..VKYAIGYENDDNWV..........----NYCLDNRDLILLDWHL.DGQS...................gEIQSLIILDKIINTP.----....-NIHF...CVIYTS.....EE..YLDG..VFKRILTNYSSltkEVYSE.YKEYTESIFGEGFDFSEFHKISM-----grnda................................
A0A502BNZ5_9RHIZ/17-189             ......................................................p-IRSVLIIDDDYPTLDEM...LELEI--IHKNGD...........................LPPKSD.........KRWHD.....................................................................NPGRIKSVIDGFRQPQRP..LLV..--DIHDGANVDTKG..........DAKVAAHLHQSDLLVLDYEL.DKNRp.................qdGARSIEILRGLITND.----....-HFNL...VVIHTS.....E-..DLDM..VYREVILGLLG...-----.----------------------------atsdeltegeqeavnqliveyedvdenalqal.....
A0A0A8WLM1_9DELT/18-212             .......................................................FVQTVVFVDDKIYAPSPK...GTVIEEKKVSAPK..........................vRKPATK........sVAKKPidlavyd.......................................................nekleetATFSPHDIQASFAKKRIV..CSL..HQPIK---RKSVGI..........ESDTYKLCASADIVIVDWDL.YGDA....................GENAKTLIENLVLQSlEEDP....HQLRL...VLIYTD.....NP..NLFD..ISDRVSERLIA..kIPKGI.EYKDADKGLAFHTLNARVVVLGKP----air..................................
A0A1G7BUG9_9FLAO/14-172             .......................................................SIKSVIFIDEKGLESYQE...TSSSTVL------...........................------.........-----.....................................................................EESLSKSLYKNFKKKGVS..LTT..----HKFSPNDLKD..........DGIKEYLLKRRDLVLLDWRL.DGDSs..................gELYSLEILSEIVKSQ.----....-HLHF...CSIYTT.....EP..KVIN..IINNIRSYFTGy.nIEYYD.KIIEDLSAYEESFGSQPFTEITYD----vkhn.................................
H2CGF8_9LEPT/16-172                 .......................................................YCRTLTVIDDDAYQTGTW...ESTNPV-------...........................------.........-----.....................................................................IDETYVALVKKCNEDSIL..CHL.qYYPNGKLGGPDIEFyk......kyYDRAVQTAKNSEVVILDWYL.GAES....................SEHSIALLKELAAD-.----....GALRF...VIVYTK.....HK..EDAT..------SSLES...EGYHR.LTISTNHSNSPVEDDDTFQPIGVHDS--qt...................................
N2A448_9FIRM/16-187                 .......................................................YLSHITYIDDDFKIAWEE...EDQEDV---KRPG...........................RSG--A........yVQKEA.....................................................................NEENTEEITKQDSLWN-F..CLF..-MQK---RYPDISLipvpyfqgitEKALKNYIDSAKLLVIDWEL.ESGA....................AKTAIDIIKESNFKN.----....-LFKL...CVIYTS.....NL..SQAQ..--EDFYKNMGY...-----.----------------------------keeqiktggegnktyiyvrdhanlfmlcek.......
G3IZQ8_METTV/23-190                 ......................................................p-IRTVVVIDDEFPSLDGL...IAEKWYGEKGRGG...........................------.........--TEE.....................................................................NAEKVRNILKACRHKDRR..WLV.dVHDGKTISTNDDQC..........---IASHLHQSDLMILDYHL.DGNDg..................sGDKAIAILRELADND.----....-YFNM...VIIYTKgygidAG..NLDR..VIGEIALGLSS...-----.----------------------------nnsaltlksqnldevndyieewelkeeg.........
A0A2S8WAZ6_9CAUL/17-176             ......................................................p-LRSVLIVDDDYPTFEDM..lVEGEPKGAAAKKT...........................WRK---.........-----.....................................................................DRERIGQVLQAFRDAEPP..LIV.dIHDGHNVGQSDETK..........---VAKHLHQSDLLILDFSL.NRNDp.................edGTKAIGIVRTLFSND.----....-HFNL...VVVHSS.....T-..DQTT..VFNDLVFGLLK...PIGEI.LSDEERTGVT------------------vrlaeyedd............................
A0A1B5FPH1_9CAUD/18-176             ......................................................a-IRSVVMIDDDFLTYSESiraLNNEVDLDYNKID...........................------.........-----.....................................................................SSKRAATLESFFQSKNMI..CDV..----------DNGS..........VNFDVDRIRKSDLIIVDYHL.DNNA....................PDKTLKLLQDLKDSD.----....-HLNM...IVIYTR.....E-..NLET..VWMQISSTLKGa.lDINSL.IIDYDNEDVQSYWEDVVLPNLNDNGN--ka...................................
A0A1W2EGB8_9SPHI/14-166             .......................................................SIKSAIFIDEKARDVYEY...ENLDDTML-----...........................------.........-----.....................................................................EEKLSVAIYKNFKENGIS..LAI..----HKFKVEDREN..........ENLLKYLFNDRDLVLLDWKL.QGEG...................gEEYSLELLSHVVHSN.----....-HINF...CCIYTT.....EP..NVDN..IFFNILSYFSG...-INET.KFAAIKEKYAPGFEDELLEIKK------syn..................................
A0A1U9Z2M5_9RHIZ/15-196             .......................................................FAHTLIVVDDEAAADLDE...PVK-SAAKIKKPSrr.......................dlAKPVAVt.......pSKSTDl...................................................................kHPLRADVLVETSMSLGLI..CSV..VKPK----PNDGAP..........-ERVAKASQKADILCVDWEM.HRDN....................GKTAVDIITRVIASD.EANG....GRFRL...IAIYTG.....VA..DKVR..ILNSVLKSIPK...TTRDR.KCLAIRENYIESADGLRIVWLFKQG---gt...................................
Q26DP9_FLABB/14-169                 .......................................................SIKSAIYIDDKARSFFED...VSEPPEI------...........................------.........-----.....................................................................EEELSVKLYNNFRENGIS..LEV..FKYS----KGDETD..........DNKITFITENRDFVILDWKLlGKTG....................EEESLKLLNEIVTAK.----....-NIHF...ATVYTS.....EN..DLED..VLLNILSYFSE...KDKDY.YIDIKEELELEEYSEEIITILHQI----nlnr.................................
D4E4H6_SEROD/15-187                 .......................................................FIQNIIFIDDKAYNSNGP...KDQ----------...........................------.........-----.....................................................................HEFDAQEVTKIFSKKGKI..CAV..YKPQL---VSDLEY..........---LTSIANKSDVTILDWQI.VLDEepaennsqndeedaeeddvrGVYTKKIITSLLGD-.IDNQ....HCIKL...ILIYTG.....EV..DLPN..IASEINAALNE...KNISG.FSINQDDPCTVMSNNCKIMVISKANG--gv...................................
A0A5R8Y7R1_9RHIZ/14-197             .......................................................FAYTMIVVDDEPVADSV-...-EQKPIAEVKTPG...........................RHDVAAa.......qKESQKpea...............................................................krsHPLDAKGLIKSALDLGMV..CSV..VNPT----GDEISV..........AESVAKASLRADIVALDWHMnDGDD....................GELASEIIKEILRGD.QDIG....GRLRL...IAIYTG.....NK..NRDD..ILDKIAHRINA...ASEIS.ETVVKNEEVLSNSAGLRLVWIEKSMG--ne...................................
A0A174GCD9_9BACE/14-169             .......................................................SIKSAVCIDDQYAEPYQK...APK----------...........................------.........-----.....................................................................NGKDAEILYHSFRQQG-K..CDL..----DIYNYNNLED.........fIKAREYLFCNKELLILDWEL.SPSAq.................nvYEDSLKILEDAINNS.----....-YIQF...ITIYTQ.....AP..SFNE..IVYRIFSYFYFn.sMENNS.LRKEKYKNLTEEIEDALSEINSD-----lssdd................................
A0A1X1MR03_9VIBR/15-201             .......................................................FIQTVLIIDDGASLGDKG...ESAAVVDAPGDPFa.........................lEEPTVDfd.....tnEE--Dsde..............................................................remsHPLRTLELTNAFYDLGIV..PGV..YQPQIRDDEDELEF..........ASKAVRVSASADIVILDWML.KEQQ....................SQYSKAIVKKILEHD.KESG....GRLRS...IIIYTG.....ET..DLSD..LRDKLLVYLNF...-----.DEIQADGDYRISGKNLIIDFYGKDKQ--vq...................................
A0A0M7ASZ6_9RHOB/14-270             .......................................................FLQTVVLVDDQADFANEA...ETPAAKEA-ETDQepnvtaetpndn..ssqemarndaskaE-----.........----SpsatrsakavdadeeaekareaeakgemarsaekaqpsadeisdeisdpdelisvsegaaseavgarqkEDLDAGAVTRGFAESGLI..CSI..LKPSA---SEPIED..........--EVSKVAPKSDVIVLDWEMgGGDS....................GDTTIKIIRKVFDCD.ERSG....ERLRL...IAIYTG.....IR..DLSL..IAAKLDAEFAA...----L.QIGEQNLELHNETGTIKLVVLGKGVA--sd...................................
A0A3N2KPE2_9BACT/14-169             .......................................................SISNAICIDDEFCAPYDT...EGR----------...........................------.........-----.....................................................................NLDAPKSMRDSFRNQH-Q..CNL..----EIYRYTNFGD.........iKTLLPVLFKNRDLLILDWEL.NPSEq.................ikYQDTLKIIEAGVDSK.----....-TLRY...IVIYTQ.....NT..DTEN..ICKVILRAFSKy.rQDFSD.IEKNILENLDEFCAENELDFDGDKV---wsl..................................
A0A4R5CBT3_9FLAO/16-181             .......................................................FLQSIVFIDDKAYSGVTE...DDP---------N...........................------.........-----.....................................................................HDFDAQKVSMAFATEKKI..CGV..YQPKT---KLDIEN..........---FKSIVKKADVVILDWKI.ILSEdeiedpn.....adddddprGIYTLDILKNIFLDI.SNNK....ESLKL...IVVYTG.....EI..DLNE..ITSQIFDELIG...----L.KPDLIKESCEVSSNNIKILIRAKSSV--ed...................................
A0A4Q2ZNS6_9SPHI/16-183             .......................................................FLQNIVFIDDKAFENNES...KGK----------...........................------.........-----.....................................................................HDFDAYAVTKAFASHKKI..CAV..YKPKI---NNDIFD..........---LAQLAKRADVTVLDWHI.ELSKeipsaasee..eeeeiedprGQHTLHIIREILSDP.IVGK....GSLKL...IVIYTG.....EV..DLDS..IANTIHTDLES...---IG.IKNIQKSFCELCTDNIKIIVIAKSD---pa...................................
A0A1C3EK79_9GAMM/18-153             ......................................................p-VRTVTVIDDEYPTLDDL...ITKTKDD-----F...........................------.........--KTD.....................................................................DIDRLREIVKVSRTSEFNwlLDV..YNGQE----DKIEE..........-KIVSNRLHHSDLLILDYHL.DGEDn.................gyCKKSIDIIKGLSTNR.----....-HFNI...VAVHTK.....--..----..-----------...-----.----------------------------gysgdkgsvkdvlvdiivslqir..............
A0A4S4BI42_9BACL/14-195             .......................................................YFDNAVIIDDELEFEQQR...LPEIKDEE--LGF..........................iPDDVDI........iDDVAPasmk.............................................................gqlpANEQPGELFHELTKEGIV..TFP..YKYQR---TADELQ..........LRWLSSILRNAKLLFLDWNL.EEAKags.............ssvaGTASLKIIEEYSKVR.----....SGLKC...AVIYTQ.....A-..DCSE..VLEEISSHFEI...VDKNA.YFFQE-----------------------rnaeegnslfgfvmnke....................
A0A6L6UCM9_9FLAO/14-168             .......................................................SIKSAVFIDENARGFFQN...QDELKG-------...........................------.........---ER.....................................................................EEEISIELFNNFKENGIS..LAI..----HQYKIDDEKN..........ENLKNYLFEDRDLVLLDWNL.DGNDs..................gQDISLQLLSDIIKRP.----....-HIHF...CTIYTS.....ESgsKIDN..VFMNILSYFSG...-ENKQ.FYDELYEDLEDE----------------eeiialkdalny.........................
E8T9T5_MESCW/17-185                 ......................................................p-IRSVLIVDDDYPTFDEM...LDAEIARNG--QK...........................EQQ---.........-KAKDw..................................................................ykDPARIKKVIASFRTPGRA..LLV..--DIHDGTNVSSGA..........EVKIAAHLHQSDLLVLDYQL.DKAKp.................gdGSLAIEIIRSLMCND.----....-HFNL...VVVHTS.....E-..ELDT..VFRETLLSLMSplaE----.----------------------------rlgpveleqaqtlllegedelegfi............
A0A4Y9PSQ1_9ACTN/14-219             .......................................................FLRTALVVDDQALTADDR...EEEADSA--ADYAlvppdalli.........gerdhgdagP-----.........----Aqtggag........................................................gadgeagGRLRTRQLVDAFADERIA..CAV..LAPRM----SVTED..........RRRVIELAASTDILVIDWLL.SPLVhaas...........kpdigDRTSLQLIREIVQND.VTSG....GRLRL...ICIYTS.....EP..AIDF..VLSEVAQGLST...-----.----------------------------ltsasvdlpfvadfdegvlagrnlmvrvvakpr....
A0A143B5B0_9DELT/25-220             .......................................................FVMNAVVVDNEPSLSGNQflsKGASSAQTFDDGMg........................ggEADEEQna.....psA---Egapde...........................................................ierniHSLDVQAISDAFSDQEIA..CAF..VLPKE--TDSDEVV..........VKRVLAAAFPADIIVIDWKL.RDGS....................HQLTKDILKKIAEKD.VAEN....GRLRL...ICVYTG.....EP..LIDQ..ITLDAVAALRE...GGLIF.DDVKKDSGYARGKYHCLQVLNKHDEG--vs...................................
A0A068QNR3_9GAMM/23-186             ......................................................p-IRSVTIIDDEYPTIAGL...LQNKQYKKV----...........................------.........-----.....................................................................NEDRLKEVIDFCHNTKRN..WIV..---DIDDGQSFIDS..........FDDSIGSYINSDLLILDYHL.EKGDhg................srSLTALNIIRNLAQKT.----....-HFNL...VVIHTSgyygnGH..DINK..IFIDIISYLQSapiI----.----------------------------nygsgtenkvndfldevtvddeefeq...........
A0A6N0WTL3_9SPHN/22-169             ......................................................a-IRTAVLIDDQFPDYLRM...SDATDEEFS----...........................------.........-----.....................................................................EIARAKHIYGFMHAKGLI..CDI..----QNWRVPDDMD..........V-HLLDKARKSDLILLDYQL.GAAG....................SKTALKILRHLAVSS.----....-HFNL...VVLYTA.....EA..NANT..-ALTVATAMRG...----L.AP--------------------------vqddtapspeileaaedilaeer..............
A0A2W2ANK7_9BACT/15-182             .......................................................FLQNIVFIDDKAFNTADG...ATN----------...........................------.........-----.....................................................................HDFDAYAVTRSFAEKNKI..CAI..YKPKT---SADIEL..........---LARLAKKADITVLDWQI.NLEDepvplgaee..edaenddprGPHTLKIIHEILSDP.ITGE....GSMKL...IIVYTG.....ET..GLTD..IRDDIHKNLEE...----N.GIAATASAFEISTDNVKIIIVAKSDNE-v....................................
A0A562VIR5_9DELT/24-229             .......................................................FVMNAVVVDNQPVLVKSP...PKGTLTAKLAAAAdegigesv..........aeeivdnehV-----.........----Aggnehdge....................................................ndpgaqkneHELDVREVSDAFAEHEIA..CAF..VFPDDSDTDEESKL..........-KRIIAATTHADIVILDWYL.KDED....................PTLTMRVLKFTAGKD.SLEK....GRMRL...ICIYTG.....QP..QIGE..VTRDAITALKE...GGLDFpDNKANIEKGIAKGEHHGLLVLNKQE---ttg..................................
A0A1R4HYG2_9GAMM/33-218             .......................................................FLKTAVVIDNEPWVSYST...PEATAPLVSDDGFge.......................diP----Tlvp..pdavT---Ie..................................................................nrHDLDVRAISDDFASKGIA..CAF..VLPDDNDKHNNEKI..........-NRAVAAAKVSDLVIIDWYL.KKQD....................ESLTLQILQKIAESD.SFEN....GRLRL...ICIYTG.....EP..LKKT..IFADAKEYLQK...-GGVS.LNDLEGEEFCALGDSTIIVMKNKAATS-a....................................
Q1NVW9_9DELT/15-225                 .......................................................YLQSVVFVDDKIYFNQSP...VDLDDLAAGAFSGlkp.....................qftEEQAGGd......mdS-AVEeeqisigelmpat...........................................saegkgedaidggGGYHPRELLESFARKGIV..CAL..YEPRE---GFDSDS..........TSDLFRLCERADVVILDWDL.HGDD....................GDGVSQLLAELIKKSeADLP....HHVRL...CALYTD.....RP..SLQP..ILLRLLEKLEE...--QGC.EVDMGEGKLQLIAGATRIAIFGKPHTA-g....................................
A0A2M9CM51_9MICO/14-208             .......................................................FLQSVVIFDDEAYTPSGG...AYTATSGAAVFDDsyg....................gmaeEHPPSR.........GAEDA.....................................................................GELDTEKVVRAFAQLGMN..CAV..LAPSGDGRERDLAL..........---LGSLARRADVVILDWLI.GSAPavttg.........dvaigeDPTSFSFIETVLAQD.SKVG....SRLRL...ICIYSG.....ER..DLER..VKASVLERLRK...-KFDQ.VFDGGEEALSVTVGDARIVFFSKVHA--eg...................................
A0A073ITG9_9RHOB/1-86               .....................................................mn------------------...-------------...........................------.........-----.....................................................................------------------..---..--------------..........--------------------.NDDD....................GLLASEIIKEILHKD.EEIG....GRLRL...IAIYTG.....DR..DKDG..ILEKIADRLNA...AEEIT.NTVSKNEDTLSNTAGLCVIWREKSGG--ne...................................
Q72B88_DESVH/18-213                 ......................................................p-IKSILFIDDKFPTHADL...LKKSLTTDTEEEHieanlrdi...........atenqfdhE-----.........---EDnthngnidi..................................................eeiqeehdrsIDEHVLRLTQSCRENGYI..FDV..----E---NNLECI..........ERDEYAFINKSDLVVLDYFLtEGED....................SSHALKIIHSLAQSK.----....-RYNL...IIVHST.....K-..EKQD..VASEILFSMKN...---IT.YENTEREELA------------------naaaieaivnenirhildgse................
A0A2S9Q7Y7_9RHIZ/21-171             ......................................................a-IRTAVLIDDQFPDYLQI...GTEDVGAFK----...........................------.........-----.....................................................................ETARAKSIYQFIHRRGLI..CDV..LNWR----EVGEAR..........-LELIDKVRKSDLIVLDYKL.DGDN....................PEPALQILRRLANTD.----....-HFNM...VVLYTA.....DV..T-AP..VAVAVAAAMRG...----V.SPPDQRAMLKPAEEEAAHDFLEDPVN--ae...................................
A0A4U1IEK0_9DELT/19-201             ......................................................g-IRTVVIIDDQMSTFEEA...LQPSA--NDVEPVslsed.................apiaqA--EDVi.......iDAESDlngdipsamfrarpsl.....................................rvskpraattlvkersEDRAAAALVKDFRSRGWL..CDV..VNANF------GGD..........---AVDRAKKSDLVVLDYIL.Q-DD....................GSGAIKILDALAHSD.----....-RMHI...VVLYTR.....EK..E-ST..VWLNIATALAK...-----.----------------------------tpivpdmppge..........................
A0A0M2VEQ7_9GAMM/15-199             ......................................................p-LRSVLIVDDQYPTWEEI...LNSHLDDDAKDAD...........................DYTRSH.........---KKlw.................................................................rtKAQGPFQVIKKFRERKPG..FVI.dIHDAVVNASPEGET..........PSQLANHLHQSDLLVLDYNL.EGADsg................lrGKKAREILYSVLSNQ.----....-HFNL...IIVHTG.....ED..DLEE..VAQECVISLMTsctSKFAV.QEVQNIASLDEAITDLEDDES-------fnratlr..............................
B3EB44_GEOLS/16-180                 .......................................................FIQSILFVDDKAYCPEQD...D------------...........................------.........-----.....................................................................HPFDVNPIIRESASKGLM..ATA..FAPEH---QDDLSM..........---VVSIGRKADVVVLDWRI.DIKNispstgvdlneeeddvadfrGNFAIQIIKSLTAEN.DVPV....DQLKL...IFIYTG.....ET..NLNE..IMTQLSESF--...-----.VCFKPLDAFTLSFGGVRISIWAKESA--ap...................................
A0A1M6J3V4_9BACT/23-222             .......................................................FLQTAMLFDDNATFEE-L...KISIKAEDVNTPNltgpe................eietpsE----Egta..gtaqK---Ekeket...........................................................erkmgENLYAKAINDAFAEEGIV..CGV..IKPK----KDDITA..........LNAIKKAARRADIVVVDWFI.NDDK....................GETALNVIEGILSEDkAEDGeahqGRLRL...LAIYTS.....EP..DLAT..ISLKVKTKFGF...--KNT.ANNTKGRYTLALNENVRLCIYQKDRGS-k....................................
A0A401FRK9_9DELT/22-230             .......................................................YIRSVLFVDDDWPEDNPQ...KKVSDSTREFSESlqsddsvsayd.....setitdesdliD-----.........----Deasedidaa..................................................sseqdkfpdmPSAAANSQLLGFKESVTG..EGI..IFQGIAYRKSHHEK..........--IIVDLASRADIVVFDWELvWKDK....................GRETLSILQELVNK-.----....GGLRF...ICIFTN.....KQ..RVHE..IKERIKERLSDe.kPDSSE.DVDKANSDGEIKPGPSEAVGKADTEK--ge...................................
A0A1G6U5J1_9PROT/24-252             .......................................................FISNVVFIDDRPVIPKSK...REIIVSPAIKDTIedevfgvdaeiaeavpsgeghvpatqaE-----.........----Sleqvdakavaenapgevd.................................dplqrndqlgtndnelneHDLPVRPLTSALAAEGVT..SSF..FFPDAS--DEEEAI..........VLQAERLALQADVVVLDWHL.RNSK....................PDLTIEVIKRILRKD.AEQK....GRLRL...ICIYTG.....EL..IQTG..IAGIIMSEVRE...----V.LELDALTENVLAANHVRIAIFNKSEV--pp...................................
A0A0G8ARU6_9SYNE/18-196             .......................................................FLQTAVVVDDEAYMESEQ...GNE-PTGEVVNPS...........................RTPRASg.......qDNQ-Dpvdr.............................................................srsrHSLDAGSIINSFSKLGVI..CGV..VSPT----NTDS--..........---VLETMRKADIVILDWLL.RDSN....................SQYTQELLRKLLDE-.EADQ....HSLRL...VSIYTG.....KQ..DLET..VCDAIVDELQG...ADLML.KPDNTKTKISYRHGHVVIYAKSNM----klke.................................
F8X1T6_9BACT/17-168                 .......................................................SIKSAIFIDDMIPGLFSS...EED----------...........................------.........-----.....................................................................KEAICQPMYESFQANQCS..LDF..FKFTK-DWATKSKL..........------IFERKDLVVLDWEL.ENEVp..................kYRSTLEIIDGAVRTD.----....-NLHF...VCIYSL.....TP..NATQ.eIHYKILAYYCGnekTKAIA.DITSFKEYVENELGENTDDI--------lprlkd...............................
A9DFR1_HOEPD/26-191                 ......................................................p-IKSVLIIDDQYPTWEQV...FGEEGYDASDTKR...........................WT----.........-----.....................................................................PKNKILKVVKQFRQMSPA..LTV..----D---IHDGQH..........NEEIGSYLCQSDLLVLDYQL.EKNEp..................hGVRAAQIVADLLNNN.----....-HFNL...VVIHTA.....IG..DLID..PFNTILMSLLT...-----.----------------------------plnisddravegfnlvealedtgeerfadvfedlkka
A0A1I7NAV2_9RHIZ/15-216             .......................................................YLQSVVFVDDEIYEHVPA...KAVKAVAAPAEAMtifrsrpve.........pqvekvievP-----.........----Dkevaatea....................................................alsaetdtgALYHPKHLVESFARERMV..CAL..YEPAK---GFETGP..........ESELFKLCERADVVILDWEF.HKEP....................GKKVMDLIGGLVTTAqTTVP....HHVRL...FAIYTS.....TQ..NLKH..VAQQVFDHLGK...---LN.LEVQTDGEYDLNAGSSRIIVLGKPTT--gr...................................
A0A229US92_9BACL/16-224             .......................................................YFKDILYVDDAIKKPTDL...KNVIELANNESAAasetvnsvqe......qpvtrrpvtysV-----.........----Dtqvnqttseqqme...........................................snqsvleaneileDYFDAFEIIYNLNSNGNK..VSP..FFFEG---DHQVET..........---VVSLIEQSHLTILDWEL.DQTG....................GETTLNILESVFRNT.----....GRLKL...LVVYTK.....NP..LQASkmIRDKFTSKIVD...--YTQ.IKVEESTIDIFDLHDAFVLVCKKREL--ps...................................
A0A6I5YGQ0_9SPHN/22-169             ......................................................a-IRTAVLIDDQFPDYLRM...SDATDEEFS----...........................------.........-----.....................................................................EIARAKHIYGFMHAKGLI..CDI..----QNWRVPDDMD..........V-HLLDKARKSDLILLDYQL.GAAG....................SKTALKILRHLAVSS.----....-HFNL...VVLYTA.....EA..NANT..-ALTVATAMRG...----L.AP--------------------------vqddtapspeileaaedilaeer..............
B2VED8_ERWT9/18-103                 ......................................................a-IRSVVMIDDDFITYSDSikaLNSEIKLDPAKID...........................------.........-----.....................................................................SSKRAATLEEYFQAKNMI..CDI..----------DNGS..........VNFDVDRIRKSDLVIIDYHL.D---....................---------------.----....-----...------.....--..----..-----------...-----.----------------------------tmhrik...............................
A0A6F8PTC5_9GAMM/16-219             .......................................................FLQTVLIIDDEIEESPHE...TKLAPPPQPEEIKapigrglpas.......sqkakinaqdK-----.........----Kpeesk..........................................................ddsseiAHTISPKISALFANEGIL..CSM..LKPE----KSDQYF..........EKRTQKALRKADITILDWKM.AKEGa.................nnDARVKSIIESIVGNEeSHKQ....KALRF...IVIYSG.....EH..KLLD..--EHIHSTKTWvddLTSEV.GKIEGEHDHQLSYNHLKFCFYAKPNE--hn...................................
A0A2V4MLB4_9RHOB/14-197             .......................................................FAYTMIVVDDEPV--DDP...VEPEPAVEVKTPG...........................RRDVAA........aK-KVDqkpe.............................................................aqrsHPLDAKGLIKSALDLGLV..CSV..VNPT----GDEGSV..........AKSVAKASLRADIVSLDWHMnHGDD....................GELASEIIQEILRGD.EAIG....GRLRL...IAIYTG.....NK..DQGA..ILEKIAERLNA...AEEIA.GNVSKTGDVLTNSSGLRIIWREKSMG--ne...................................
A0A5Q0BI77_9GAMM/1-59               ......................................................m------------------...-------------...........................------.........-----.....................................................................------------------..---..--------------..........-------------LILDYHL.DGNQ...................gSEKAINILRRLAGNS.----....-NFNL...VVVYTQ.....NR..SEA-..-----------...-----.----------------------------gagientineialsla.....................
A1BCM1_CHLPD/22-219                 .......................................................YLQTVVLIDDKIYPPKAV...RTPTDLQEPPSRHrkaask...............saepvlE-----.........--KKEvidkla.........................................................eeidqsEEVSFHDIQNSFAEKRII..CSL..YQPKQ---GASFNS..........SSDVYNLCSVADVVVVDWDI.HGDS....................GKKATELVVTLIEQSmKEVP....HQLRL...VLIYTM.....DP..NLGS..VANSVYEAFSSq.iDTALI.DVLEDGNGLVFTSENARVVVLGKKIN--ta...................................
A0A1H8XA45_9SPHI/34-187             .......................................................SIKSVVFIDEKALEFYKK...IPKVLEP------...........................------.........-----.....................................................................EERLSINLLNRFKKRGAS..LAV..----HKFNSSDISN..........VELKKYLFDNRDLVLLDWEL.DQDYv.................vgKGYSLKLLSDVVSTS.----....-HLHF...CAIYTS.....TI..RDAD..VFDNIISFFSG...--RTS.VQFEEIRDALSEHEDGLRKV--------lnrvdl...............................
A0A2H5AUB7_9ACTN/14-210             .......................................................YLQTVVVIDDGLLLGVED...ASGEAEVVDPVDPlevd..................paegeG----Et.......kT---Qgsagqd.........................................................ldgapdDLLRGEQLIRGFAEKGLV..CGL..LKPSSGQELEDIKS..........-GQYQRLFARADVMVLDWSL.ARDE....................GATTRKLILDLVGKS.EERV....KRLRL...ICIYTN.....SP..NLAS..IQESIALDLRA..dGINSF.VGGEMERDWFVQGGDFRIAILGKTGVS-r....................................
I2B9G7_SHIBC/20-208                 .......................................................FLKTAVVIDNQPWVKSSN...RNVHLPISTDTGFgden...................tfvlENPDVE........iSEHNE.....................................................................HDLNIRAISDVFAEKGIA..CAF..VLPDDDAGEERDSK..........VNKVLQAAKISDLIVIDWYL.ERQS....................SSLTLEILEKIAKAD.DSDN....GRLRL...LCVYTG.....EP..LGEE..IFDEIKQYLKR...-GGVT.VNDVSDIDYCAENASTIVILRNKTDTQ-a....................................
A0A5C8JFG5_9BACT/19-222             .......................................................FLHSVVVVDDRASLNDEVn.iSNSYTPKDVALKApstrakkvq.........tivettlqqN-----.........----Ehsegveega..................................................pnkdgdntnnRDLKAKILIDTFAEIGLV..CAV..LKPV----DKDERL..........ESQTDHATQKSDIVILDWQI.SESEt.................spGETALRLIKKIIKTD.--SK....DRLRL...IAIYTT.....SQ..DLHG..ITEKVSDVIKT...----P.SETASIDGFEITRGPIKVVIYQKSGG--tt...................................
T2GB31_DESGG/15-188                 .......................................................FLQTVVVIDDQAYDVQNE...KTAIPLKSPSRGQa.........................kA--DDSse....daaRT--Qv...................................................................aHSLDTSQLVSAFACKGLV..CAV..IAPQK-----DEPV..........EQRLGSVVDRCDIVIIDWQM.FNDD....................GKQTLSLIKHLCEGD.--CG....NRLRL...LCVYSG.....EP..DLEK..ISDQITGKKFG...-----.FTCHDNNKLLLRKDHVIVTILGKSVV--pv...................................
A0A2G8DX51_9GAMM/18-176             ......................................................a-IRSVVMIDDDFITYSDSikaLNREIELDPAKID...........................------.........-----.....................................................................SSKRAATLEGYFQSKNMI..CDI..----------DNGS..........VNFDVDRIRKSDLVIMDYHL.DNNA....................PDKTISILKELKSSD.----....-HLNM...IVIYTR.....E-..ELET..VWMQIASSLKGt.vKINDR.IVDTNNDDLIDYWENTILPDLAQ-----igdrs................................
A0A084A0Z1_9GAMM/17-216             .......................................................FLNSVIAIDDNLFFEKKH...QAS-SIMDVDDGFdiive................edsglgQSVN--.........----Tqsvsrr........................................................eqgapinHPLDYQDLSLAFADYGIN..CCA..FRPDIESLESIESA..........ADKIKKIAKRTDITILDWSM.DDKYgv................qaGTLAKLSINKILQDD.KLQN....GRLRL...IVIYTG.....EP..NPLD..IAENIRQDISS...--LDI.KAIRNGGSIVFQCPDLEFCQITIIE---kkv..................................
A0A1M6C629_9BACT/15-170             .......................................................FCKSLVWIDDQILPESDD...PALRLQ-------...........................------.........-----.....................................................................YREFYHPISKAISDEGII..CHL.rGFPSIRSLEEDDYSeeed..idndIQQCSNLATQADIIILDWHLgYEDR....................PELAVRIIKEIASLR.----....-GARF...LVILSR.....KE..NLTS..---EFKSEFPE...-----.----------------------------ferngdwftngqlnvvlkhkqdfd.............
N0E0J6_9MICO/16-204                 .......................................................FLQTILMIDDEAFRRDSG...PEQAADEDWADDD...........................-TPPVGsalklvapgA---Sa..................................................................egDELDVQAVSRSFAEAALS..CAI..LSPQSAEENEDFRP..........--AFVRTAKRADALILDWNL.NGDN....................GATAEKLIRAVLREDtKSPR....RRLRL...VTVYTG.....EP..DLRQ..ITDRIANATSE..sLGEDE.LKWDDDRHVAFSRGPVRVAVFAKEHVQ-s....................................
A0A3S2V3B0_9RHIZ/17-170             ......................................................p-IRSVLIVDDDYPTFEEM...LSDGESLGKDWRN...........................------.........-----.....................................................................QTDRVRKIIRGFRARNLL..VDI..----HDGRNVGLDD..........EIREAEHLHQSDLLVLDYQL.DKTRa.................gdGSIAINIIRKLMANT.----....-HFNL...VVVHTS.....E-..NLDA..VFQNVILALLP...--YEL.YELTQDDLFLVDE---------------aleelrsr.............................
A0A1V0PYV6_9RHOB/18-209             .......................................................FIQTAVFVDDRIYERQDN...TTGDTKSVVAPKT...........................RKKAIK........sVEAEDpiqea..........................................................eigesdSLPDARDIVTSFAKKQIV..CSL..YQPKKTAKYSPESD..........---IFPLCKAADVVILDWDL.FGDG....................GERASELAEGLVTQAvKDVP....EQLRL...ILIYTQ.....EA..NLFD..IANRLYEKITG..sIGDSL.VPRPEDGGLAFHTENSRVVVLGKPGR--tr...................................
A0A081NMD5_9GAMM/15-203             .......................................................FLKTVVCFDDQAYEDSLL...GPN---MVASLPGsg......................fddSEDSFSd.......iSEVEDtael............................................................tdiqsHSLNAQELTGSFAAKGIQ..CSV..IKTS----DEPLDA..........KRQIVTMSMAADIMLLDWQL.ENLSde................ykTTLIGDAIVEILRND.QEGG....GRLRL...IVIFSG.....EK..E-EG..VLSTLTQKLSD...----L.HFSRTPGSYELKHGSTKIVFIGKPEG--vs...................................
F9RCY2_VIBSN/15-186                 .......................................................FIQSIIFIDDKAYKNTAV...ADQ----------...........................------.........-----.....................................................................HDFDAKEITKIFAADGKV..CAV..YEPTS---TQDIES..........---LISVAKKADVAVIDWQI.VIEEntineeidd.eadaeiddvrGVYTKQIITQLLSD-.ESCK....NSVKL...LLIYTG.....ET..DLEQ..IAIDVLDHLVI...NNLND.FSIDKNDSCTIKSSFCKIMVIAKSNRD-d....................................
#=GC seq_cons                       ........................................................lpollhIDDchhp.pp....hstt.............................................................................................................................cphcspplhcsFtppuhh..Csl..h.spt...ts-.ps.............lhphhcpuDlllLDWpL.ptss....................uppulpIlcclhpss..........+l+L...lsIYTu.....c...slss..lhpplhpthpt............tt.pth..t.tt.hh.hht......st...................................
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