#=GF ID RhoGEF
#=GF AC PF00621.23
#=GF DE RhoGEF domain
#=GF AU SMART;
#=GF SE Alignment kindly provided by SMART
#=GF GA 27.60 27.60;
#=GF TC 27.60 27.60;
#=GF NC 27.50 27.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK RhoGEF_domain
#=GF RN [1]
#=GF RM 8791419
#=GF RT The Dbl family of oncogenes.
#=GF RA Cerione RA, Zheng Y;
#=GF RL Curr Opin Cell Biol 1996;8:216-222.
#=GF RN [2]
#=GF RM 1956381
#=GF RT Catalysis of guanine nucleotide exchange on the CDC42Hs protein
#=GF RT by the dbl oncogene product.
#=GF RA Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA;
#=GF RL Nature 1991;354:311-314.
#=GF RN [3]
#=GF RM 8262969
#=GF RT The human active breakpoint cluster region-related gene encodes
#=GF RT a brain protein with homology to guanine nucleotide exchange
#=GF RT proteins and GTPase-activating proteins.
#=GF RA Tan EC, Leung T, Manser E, Lim L;
#=GF RL J Biol Chem 1993;268:27291-27298.
#=GF RN [4]
#=GF RM 9790532
#=GF RT Crystal structure of the Dbl and pleckstrin homology domains
#=GF RT from the human Son of sevenless protein.
#=GF RA Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J;
#=GF RL Cell 1998;95:259-268.
#=GF DR INTERPRO; IPR000219;
#=GF DR SMART; RhoGEF;
#=GF DR SCOP; 1dbh; fa;
#=GF DR HOMSTRAD; RhoGEF;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like
#=GF CC GTPases Also called Dbl-homologous (DH) domain. It appears that
#=GF CC Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH
#=GF CC domains.
#=GF SQ 56628
#=GS A0A2I4CYZ2_9TELE/4908-5085 AC A0A2I4CYZ2.1
#=GS A0A4W2EQZ9_BOBOX/878-1060 AC A0A4W2EQZ9.1
#=GS A0A2A9P0G6_9AGAR/80-265 AC A0A2A9P0G6.1
#=GS A0A674AT42_SALTR/206-386 AC A0A674AT42.1
#=GS A0A452RDA7_URSAM/257-431 AC A0A452RDA7.1
#=GS A0A663MMW4_ATHCN/1235-1415 AC A0A663MMW4.1
#=GS A0A5C2SPT8_9APHY/936-1000 AC A0A5C2SPT8.1
#=GS A0A3Q2H5T4_HORSE/269-438 AC A0A3Q2H5T4.2
#=GS A0A5N5K039_PANHP/175-348 AC A0A5N5K039.1
#=GS A0A672KUW6_SINGR/94-268 AC A0A672KUW6.1
#=GS A0A2S5B5B4_9BASI/269-491 AC A0A2S5B5B4.1
#=GS A0A1U7V2U1_CARSF/143-326 AC A0A1U7V2U1.1
#=GS A0A669F154_ORENI/198-370 AC A0A669F154.1
#=GS D4A1J1_RAT/125-301 AC D4A1J1.1
#=GS A0A6J2I3C0_9PASS/107-285 AC A0A6J2I3C0.1
#=GS A0A1S3PDQ7_SALSA/189-367 AC A0A1S3PDQ7.1
#=GS A0A2K5PS12_CEBIM/873-1056 AC A0A2K5PS12.1
#=GS A0A671DU90_RHIFE/168-354 AC A0A671DU90.1
#=GS A0A668VJ03_OREAU/583-759 AC A0A668VJ03.1
#=GS A0A6J0CQY2_PERMB/103-284 AC A0A6J0CQY2.1
#=GS A0A6J2WSF8_CHACN/548-733 AC A0A6J2WSF8.1
#=GS A0A6J1NB62_BICAN/1662-1833 AC A0A6J1NB62.1
#=GS A0A5F8MPF6_MOUSE/210-401 AC A0A5F8MPF6.1
#=GS A0A6J0D723_PERMB/284-475 AC A0A6J0D723.1
#=GS A0A6P8U960_GYMAC/147-320 AC A0A6P8U960.1
#=GS A0A2A2JAL3_9BILA/1160-1327 AC A0A2A2JAL3.1
#=GS K5WQA6_PHACS/12-201 AC K5WQA6.1
#=GS A0A2K5NI18_CERAT/107-285 AC A0A2K5NI18.1
#=GS A0A6P7KVR0_BETSP/199-372 AC A0A6P7KVR0.1
#=GS A0A6P6NB02_CARAU/1-85 AC A0A6P6NB02.1
#=GS A0A0D9RNP0_CHLSB/100-292 AC A0A0D9RNP0.1
#=GS U3JGK9_FICAL/203-386 AC U3JGK9.1
#=GS A0A6J1PAU7_BICAN/661-854 AC A0A6J1PAU7.1
#=GS A0A5F9CFV0_RABIT/716-883 AC A0A5F9CFV0.1
#=GS A0A067RH01_ZOONE/356-531 AC A0A067RH01.1
#=GS A0A218VC28_9PASE/27-212 AC A0A218VC28.1
#=GS A0A2Y9SSC3_PHYMC/694-882 AC A0A2Y9SSC3.1
#=GS A0A663N3P5_ATHCN/245-414 AC A0A663N3P5.1
#=GS A0A3Q3XMM5_MOLML/55-224 AC A0A3Q3XMM5.1
#=GS A0A6G1G680_9PEZI/262-440 AC A0A6G1G680.1
#=GS A0A2T9Z203_9FUNG/198-366 AC A0A2T9Z203.1
#=GS A0A0V0ZMH2_9BILA/138-309 AC A0A0V0ZMH2.1
#=GS A0A183SX44_SCHSO/49-235 AC A0A183SX44.1
#=GS A0A6P7F730_DIAVI/435-623 AC A0A6P7F730.1
#=GS A0A6P6H233_PUMCO/455-638 AC A0A6P6H233.1
#=GS OBSCN_MOUSE/6646-6823 AC A2AAJ9.3
#=GS A0A6P7L0L4_BETSP/5235-5413 AC A0A6P7L0L4.1
#=GS A0A0A1TU71_ENTIV/408-608 AC A0A0A1TU71.1
#=GS A0A1Y3P0A1_PIRSE/701-874 AC A0A1Y3P0A1.1
#=GS A0A091ILP3_CALAN/379-564 AC A0A091ILP3.1
#=GS A0A672SFZ8_SINGR/135-315 AC A0A672SFZ8.1
#=GS A0A6J3QCM6_TURTR/473-656 AC A0A6J3QCM6.1
#=GS A0A667WYG5_9TELE/165-338 AC A0A667WYG5.1
#=GS A0A4X2LKQ0_VOMUR/387-565 AC A0A4X2LKQ0.1
#=GS A0A2P6MVN7_9EUKA/1-170 AC A0A2P6MVN7.1
#=GS A0A409YH03_9AGAR/596-785 AC A0A409YH03.1
#=GS A0A6P8H591_ACTTE/1973-2138 AC A0A6P8H591.1
#=GS A0A670IC73_PODMU/1102-1282 AC A0A670IC73.1
#=GS A0A5N5MW02_PANHP/623-797 AC A0A5N5MW02.1
#=GS A0A2K6TAU0_SAIBB/303-481 AC A0A2K6TAU0.1
#=GS A0A6J1XTW1_ACIJB/855-1044 AC A0A6J1XTW1.1
#=GS A0A0P7ULC0_SCLFO/515-706 AC A0A0P7ULC0.1
#=GS A0A6A5FHI3_PERFL/1757-1939 AC A0A6A5FHI3.1
#=GS A0A5F4BZC0_CANLF/1044-1232 AC A0A5F4BZC0.1
#=GS A0A3Q7T8R6_VULVU/2001-2192 AC A0A3Q7T8R6.1
#=GS A0A2I3S7P6_PANTR/1243-1416 AC A0A2I3S7P6.1
#=GS A0A2I3G9R5_NOMLE/217-395 AC A0A2I3G9R5.1
#=GS A0A267FCT3_9PLAT/242-422 AC A0A267FCT3.1
#=GS A0A267E8B9_9PLAT/510-689 AC A0A267E8B9.1
#=GS A0A2K5KN56_CERAT/132-308 AC A0A2K5KN56.1
#=GS A0A168I6P8_MUCCL/98-282 AC A0A168I6P8.1
#=GS A0A4W4FCL3_ELEEL/106-282 AC A0A4W4FCL3.1
#=GS H2YPF9_CIOSA/221-401 AC H2YPF9.1
#=GS A0A2I3SL02_PANTR/318-499 AC A0A2I3SL02.1
#=GS A0A1D2MQ78_ORCCI/721-894 AC A0A1D2MQ78.1
#=GS A0A2K5PP59_CEBIM/97-271 AC A0A2K5PP59.1
#=GS A0A384C489_URSMA/171-349 AC A0A384C489.1
#=GS F7BQ90_MACMU/387-565 AC F7BQ90.3
#=GS M3Z1J0_MUSPF/333-524 AC M3Z1J0.1
#=GS Q9VEF9_DROME/158-340 AC Q9VEF9.1
#=GS A0A2Y9SI58_PHYMC/202-371 AC A0A2Y9SI58.1
#=GS A0A0Q9WRW2_DROWI/15-195 AC A0A0Q9WRW2.1
#=GS A0A484CZX7_PERFV/707-898 AC A0A484CZX7.1
#=GS A0A665XDX7_ECHNA/338-519 AC A0A665XDX7.1
#=GS A0A6J3L4D0_9HYME/862-1044 AC A0A6J3L4D0.1
#=GS A0A6P8VKR9_GYMAC/761-941 AC A0A6P8VKR9.1
#=GS A0A367LPT1_9HYPO/251-457 AC A0A367LPT1.1
#=GS A0A1U7S838_ALLSI/7-187 AC A0A1U7S838.1
#=GS A0A668AUT1_9TELE/1194-1374 AC A0A668AUT1.1
#=GS A0A6J3F4L3_SAPAP/38-221 AC A0A6J3F4L3.1
#=GS A0A5N4DA24_CAMDR/46-231 AC A0A5N4DA24.1
#=GS A0A7E6DH70_9CHIR/202-374 AC A0A7E6DH70.1
#=GS A0A671F7A2_RHIFE/513-700 AC A0A671F7A2.1
#=GS A0A6P7NYJ1_BETSP/1252-1424 AC A0A6P7NYJ1.1
#=GS A0A6I8SH41_XENTR/270-444 AC A0A6I8SH41.2
#=GS A0A6I9LJU9_PERMB/81-259 AC A0A6I9LJU9.1
#=GS A0A672IDE9_SALFA/119-295 AC A0A672IDE9.1
#=GS A0A4C1TJ60_EUMVA/67-255 AC A0A4C1TJ60.1
#=GS A0A1J4KF27_9EUKA/185-354 AC A0A1J4KF27.1
#=GS C3YJI7_BRAFL/401-583 AC C3YJI7.1
#=GS A0A7N8WVU6_9TELE/189-369 AC A0A7N8WVU6.1
#=GS A0A1Y1WDB4_9FUNG/674-833 AC A0A1Y1WDB4.1
#=GS A0A7F8Q9D1_LEPWE/98-280 AC A0A7F8Q9D1.1
#=GS A0A1S3PB60_SALSA/630-804 AC A0A1S3PB60.1
#=GS A0A0L0N869_TOLOC/253-462 AC A0A0L0N869.1
#=GS S7QDN4_GLOTA/216-385 AC S7QDN4.1
#=GS S7QH17_GLOTA/105-290 AC S7QH17.1
#=GS A0A6J1RTM5_FRAOC/1197-1376 AC A0A6J1RTM5.1
#=GS A0A673BGG8_9TELE/244-424 AC A0A673BGG8.1
#=GS M0R3X3_RAT/192-373 AC M0R3X3.2
#=GS A0A287BDP5_PIG/26-195 AC A0A287BDP5.2
#=GS A0A091Q660_LEPDC/164-338 AC A0A091Q660.1
#=GS H2QKY3_PANTR/1044-1232 AC H2QKY3.1
#=GS A0A671UCB2_SPAAU/246-426 AC A0A671UCB2.1
#=GS G5BGA7_HETGA/798-981 AC G5BGA7.1
#=GS A0A6J1NY50_BICAN/132-311 AC A0A6J1NY50.1
#=GS A0A093R226_PHACA/226-404 AC A0A093R226.1
#=GS A0A6J3GF41_SAPAP/240-431 AC A0A6J3GF41.1
#=GS A0A663N7Y1_ATHCN/1245-1418 AC A0A663N7Y1.1
#=GS A0A0Q3P4E8_AMAAE/152-330 AC A0A0Q3P4E8.1
#=GS A0A2R9A6W5_PANPA/1258-1431 AC A0A2R9A6W5.1
#=GS A0A1U7SYA0_CARSF/232-423 AC A0A1U7SYA0.1
#=GS A0A074S603_9AGAM/1137-1341 AC A0A074S603.1
#=GS B8PJ84_POSPM/183-467 AC B8PJ84.1
#=GS A0A1Y3NG76_PIRSE/446-633 AC A0A1Y3NG76.1
#=GS A0A7N9D3U3_MACFA/245-417 AC A0A7N9D3U3.1
#=GS A0A1J4KTD7_9EUKA/203-377 AC A0A1J4KTD7.1
#=GS A0A3B3IBM2_ORYLA/196-387 AC A0A3B3IBM2.1
#=GS A0A5F9DSZ6_RABIT/120-282 AC A0A5F9DSZ6.1
#=GS A0A2K5PS19_CEBIM/871-1054 AC A0A2K5PS19.1
#=GS A0A455AP78_PHYMC/48-225 AC A0A455AP78.1
#=GS A0A673WLL6_SALTR/1011-1199 AC A0A673WLL6.1
#=GS A0A668T9X9_OREAU/202-385 AC A0A668T9X9.1
#=GS A0A0V1PCK5_9BILA/207-398 AC A0A0V1PCK5.1
#=GS A0A6P6JQT3_CARAU/217-395 AC A0A6P6JQT3.1
#=GS A0A1V4J4V4_PATFA/647-821 AC A0A1V4J4V4.1
#=GS A0A5N5TGT3_9CRUS/10-196 AC A0A5N5TGT3.1
#=GS A0A096N081_PAPAN/284-475 AC A0A096N081.2
#=GS W5K0H8_ASTMX/933-1102 AC W5K0H8.2
#=GS H9GF94_ANOCA/1-149 AC H9GF94.1
#=GS A0A152A6S1_9MYCE/37-222 AC A0A152A6S1.1
#=GS A0A1B9I7V8_9TREE/1026-1278 AC A0A1B9I7V8.1
#=GS A0A674F198_SALTR/120-296 AC A0A674F198.1
#=GS A0A6P6N867_CARAU/8-185 AC A0A6P6N867.1
#=GS A0A6P8GK79_CLUHA/217-298 AC A0A6P8GK79.1
#=GS A0A2K6UR45_SAIBB/105-296 AC A0A2K6UR45.1
#=GS A0A670YTY4_PSETE/154-237 AC A0A670YTY4.1
#=GS A0A3Q7W2I5_URSAR/376-558 AC A0A3Q7W2I5.1
#=GS S2JK55_MUCC1/102-292 AC S2JK55.1
#=GS A0A7N6BT19_ANATE/74-262 AC A0A7N6BT19.1
#=GS A0A6J3QBZ0_TURTR/254-428 AC A0A6J3QBZ0.1
#=GS A0A2G4T7P2_RHIZD/106-295 AC A0A2G4T7P2.1
#=GS A0A1X2HME6_SYNRA/38-213 AC A0A1X2HME6.1
#=GS A0A3Q7R7Z7_CALUR/793-970 AC A0A3Q7R7Z7.1
#=GS A0A2P4ZI40_9HYPO/1132-1343 AC A0A2P4ZI40.1
#=GS A0A7F8KF51_DELLE/668-842 AC A0A7F8KF51.1
#=GS A0A3Q0CIP0_MESAU/153-331 AC A0A3Q0CIP0.1
#=GS G3JLH4_CORMM/112-326 AC G3JLH4.1
#=GS A0A484DFV0_PERFV/251-432 AC A0A484DFV0.1
#=GS A0A2T9ZAF6_9FUNG/876-1134 AC A0A2T9ZAF6.1
#=GS A0A6P3VHT0_CLUHA/168-344 AC A0A6P3VHT0.1
#=GS B4L5C3_DROMO/18-185 AC B4L5C3.1
#=GS A0A2K5XVY9_MANLE/107-285 AC A0A2K5XVY9.1
#=GS A0A6A4JRL8_APOLU/94-184 AC A0A6A4JRL8.1
#=GS B3M4P5_DROAN/1026-1212 AC B3M4P5.1
#=GS A0A3Q1HIJ3_ANATE/1230-1401 AC A0A3Q1HIJ3.1
#=GS A0A6A6YGS8_9PEZI/846-1032 AC A0A6A6YGS8.1
#=GS A0A6J0TTG2_9SAUR/1173-1353 AC A0A6J0TTG2.1
#=GS A0A6G0HT92_LARCR/247-438 AC A0A6G0HT92.1
#=GS A7RJS1_NEMVE/284-413 AC A7RJS1.1
#=GS A0A2Y9HP02_NEOSC/269-438 AC A0A2Y9HP02.1
#=GS H3CSU3_TETNG/213-390 AC H3CSU3.1
#=GS A0A0V1CM40_TRIBR/207-398 AC A0A0V1CM40.1
#=GS A0A2T9ZLB8_9FUNG/696-877 AC A0A2T9ZLB8.1
#=GS A0A0L0FT69_9EUKA/127-335 AC A0A0L0FT69.1
#=GS A0A1S3LRD0_SALSA/392-579 AC A0A1S3LRD0.1
#=GS A0A5F5XMD2_FELCA/766-950 AC A0A5F5XMD2.1
#=GS A0A6G1PWR8_9TELE/821-1006 AC A0A6G1PWR8.1
#=GS A0A096M8U4_POEFO/613-784 AC A0A096M8U4.1
#=GS A0A452EL38_CAPHI/2011-2202 AC A0A452EL38.1
#=GS A0A340XU33_LIPVE/456-639 AC A0A340XU33.1
#=GS A0A1S3KSQ3_SALSA/879-1062 AC A0A1S3KSQ3.1
#=GS A0A060Y1Z8_ONCMY/4-172 AC A0A060Y1Z8.1
#=GS A0A6J3K5M8_9HYME/281-462 AC A0A6J3K5M8.1
#=GS A0A6J2TBG7_DROLE/653-838 AC A0A6J2TBG7.1
#=GS A0A3P9QG14_POERE/64-228 AC A0A3P9QG14.1
#=GS S9YFH5_CAMFR/58-228 AC S9YFH5.1
#=GS A0A5G2RCI1_PIG/171-349 AC A0A5G2RCI1.1
#=GS A0A7M7MZF8_STRPU/539-721 AC A0A7M7MZF8.1
#=GS A0A1S3MFB5_SALSA/1325-1494 AC A0A1S3MFB5.1
#=GS A0A0V1NNW3_9BILA/789-969 AC A0A0V1NNW3.1
#=GS A0A2U3ZAS6_ODORO/198-371 AC A0A2U3ZAS6.1
#=GS A0A024UQR4_9STRA/85-268 AC A0A024UQR4.1
#=GS A0A151LZI5_ALLMI/7543-7722 AC A0A151LZI5.1
#=GS A0A6P3R1W7_PTEVA/126-302 AC A0A6P3R1W7.1
#=GS A0A0Q9W472_DROVI/718-894 AC A0A0Q9W472.1
#=GS A0A151X226_9HYME/1242-1431 AC A0A151X226.1
#=GS A0A2Y9HG54_NEOSC/1256-1429 AC A0A2Y9HG54.1
#=GS A0A1Y2AXN9_9TREE/835-1016 AC A0A1Y2AXN9.1
#=GS A0A6P6NWB2_CARAU/244-424 AC A0A6P6NWB2.1
#=GS A0A6P3H4P9_BISBI/425-608 AC A0A6P3H4P9.1
#=GS A0A3P8XYE5_ESOLU/1085-1273 AC A0A3P8XYE5.1
#=GS A0A6J3QDK3_TURTR/105-280 AC A0A6J3QDK3.1
#=GS A0A6J1SG27_FRAOC/946-1111 AC A0A6J1SG27.1
#=GS A0A0A2J7Z3_PENEN/175-348 AC A0A0A2J7Z3.1
#=GS A0A016TXX4_9BILA/357-538 AC A0A016TXX4.1
#=GS A0A6P8YKT5_THRPL/316-501 AC A0A6P8YKT5.1
#=GS A0A384DRH2_URSMA/1075-1234 AC A0A384DRH2.1
#=GS A0A7M7QBH2_NASVI/1450-1638 AC A0A7M7QBH2.1
#=GS A0A6P7P2B3_BETSP/1020-1208 AC A0A6P7P2B3.1
#=GS F1MPJ6_BOVIN/397-583 AC F1MPJ6.3
#=GS G1X7D9_ARTOA/1086-1297 AC G1X7D9.1
#=GS A0A6P7JQD4_9TELE/121-309 AC A0A6P7JQD4.1
#=GS A0A091VTE4_NIPNI/1-142 AC A0A091VTE4.1
#=GS A0A4W6G994_LATCA/26-213 AC A0A4W6G994.1
#=GS A0A672IUU9_SALFA/177-355 AC A0A672IUU9.1
#=GS A0A093PCF5_PYGAD/538-725 AC A0A093PCF5.1
#=GS A0A673V7Z6_SURSU/198-371 AC A0A673V7Z6.1
#=GS A0A4W5JIZ2_9TELE/1820-1990 AC A0A4W5JIZ2.1
#=GS A0A6I9HSQ4_GEOFO/101-283 AC A0A6I9HSQ4.1
#=GS A0A668VVV3_OREAU/112-290 AC A0A668VVV3.1
#=GS A0A091LCC6_CATAU/13-182 AC A0A091LCC6.1
#=GS A0A452GAV1_CAPHI/107-289 AC A0A452GAV1.1
#=GS A0A225ASF6_9EURO/528-714 AC A0A225ASF6.1
#=GS A0A671W2E4_SPAAU/961-1149 AC A0A671W2E4.1
#=GS A0A6P6BTC9_PTEVA/173-351 AC A0A6P6BTC9.1
#=GS A0A3L8S5P7_CHLGU/33-211 AC A0A3L8S5P7.1
#=GS A0A2Y9RH14_TRIMA/91-265 AC A0A2Y9RH14.1
#=GS A0A3P8YTA6_ESOLU/1-176 AC A0A3P8YTA6.2
#=GS A0A067CJP0_SAPPC/660-889 AC A0A067CJP0.1
#=GS A0A094MPH9_PODCR/612-785 AC A0A094MPH9.1
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