#=GF ID RhoGEF
#=GF AC PF00621.24
#=GF DE RhoGEF domain
#=GF AU SMART;
#=GF SE Alignment kindly provided by SMART
#=GF GA 27.60 27.60;
#=GF TC 27.60 27.60;
#=GF NC 27.50 27.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF WK RhoGEF_domain
#=GF RN [1]
#=GF RM 8791419
#=GF RT The Dbl family of oncogenes.
#=GF RA Cerione RA, Zheng Y;
#=GF RL Curr Opin Cell Biol 1996;8:216-222.
#=GF RN [2]
#=GF RM 1956381
#=GF RT Catalysis of guanine nucleotide exchange on the CDC42Hs protein
#=GF RT by the dbl oncogene product.
#=GF RA Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA;
#=GF RL Nature 1991;354:311-314.
#=GF RN [3]
#=GF RM 8262969
#=GF RT The human active breakpoint cluster region-related gene encodes
#=GF RT a brain protein with homology to guanine nucleotide exchange
#=GF RT proteins and GTPase-activating proteins.
#=GF RA Tan EC, Leung T, Manser E, Lim L;
#=GF RL J Biol Chem 1993;268:27291-27298.
#=GF RN [4]
#=GF RM 9790532
#=GF RT Crystal structure of the Dbl and pleckstrin homology domains
#=GF RT from the human Son of sevenless protein.
#=GF RA Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J;
#=GF RL Cell 1998;95:259-268.
#=GF DR INTERPRO; IPR000219;
#=GF DR SMART; RhoGEF;
#=GF DR SCOP; 1dbh; fa;
#=GF DR HOMSTRAD; RhoGEF;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like
#=GF CC GTPases Also called Dbl-homologous (DH) domain. It appears that
#=GF CC Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH
#=GF CC domains.
#=GF SQ 90396
#=GS A0A6P4J0E4_DROKI/593-758 AC A0A6P4J0E4.1
#=GS A0A8B6DRU7_MYTGA/498-680 AC A0A8B6DRU7.1
#=GS A0A663EAY1_AQUCH/1615-1806 AC A0A663EAY1.1
#=GS A0A2U3WM58_ODORO/269-438 AC A0A2U3WM58.1
#=GS A0A671DST4_RHIFE/1238-1418 AC A0A671DST4.1
#=GS I1RWA9_GIBZE/547-732 AC I1RWA9.1
#=GS A0A8C2YFK0_COTJA/520-698 AC A0A8C2YFK0.1
#=GS A0A433TUQ5_ELYCH/745-918 AC A0A433TUQ5.1
#=GS A0A672Q460_SINGR/101-282 AC A0A672Q460.1
#=GS A0A6P6MM57_CARAU/166-342 AC A0A6P6MM57.1
#=GS A0A2K5JNT8_COLAP/1906-2075 AC A0A2K5JNT8.1
#=GS A0A8H6W9F2_MYCCL/1220-1473 AC A0A8H6W9F2.1
#=GS E4X194_OIKDI/17-142 AC E4X194.1
#=GS E3NHY8_CAERE/484-660 AC E3NHY8.1
#=GS V8P932_OPHHA/564-699 AC V8P932.1
#=GS A0A8D0B630_SALMN/246-312 AC A0A8D0B630.1
#=GS A0A852LEG9_UROIN/456-633 AC A0A852LEG9.1
#=GS A0A852CU48_PASAF/1-133 AC A0A852CU48.1
#=GS A0A7L1C1E6_9PASS/869-1052 AC A0A7L1C1E6.1
#=GS A0A4W6F9Q6_LATCA/1-167 AC A0A4W6F9Q6.1
#=GS A0A096LR96_POEFO/281-459 AC A0A096LR96.1
#=GS A0A4U5U663_COLLU/1517-1674 AC A0A4U5U663.1
#=GS A0A8C7ZA77_9TELE/225-399 AC A0A8C7ZA77.1
#=GS A0A811YX74_NYCPR/635-809 AC A0A811YX74.1
#=GS A0A7L0J949_PIPCL/1897-2067 AC A0A7L0J949.1
#=GS A0A8C4WJA9_9SAUR/376-554 AC A0A8C4WJA9.1
#=GS A0A2K6UXM0_SAIBB/198-371 AC A0A2K6UXM0.1
#=GS A0A4Q9PL60_9APHY/386-459 AC A0A4Q9PL60.1
#=GS A0A7L4DUU9_9AVES/245-419 AC A0A7L4DUU9.1
#=GS A0A5F5Y608_FELCA/428-548 AC A0A5F5Y608.1
#=GS A0A096M253_POEFO/5-171 AC A0A096M253.1
#=GS A0A152A6S1_TIELA/37-222 AC A0A152A6S1.1
#=GS A0A663EZ01_AQUCH/1078-1256 AC A0A663EZ01.1
#=GS A0A8C8S581_9SAUR/338-521 AC A0A8C8S581.1
#=GS A0A3S2LE36_CHISP/498-681 AC A0A3S2LE36.1
#=GS A0A8P0P4R1_CANLF/109-287 AC A0A8P0P4R1.1
#=GS A0A3P9A3K1_ESOLU/59-238 AC A0A3P9A3K1.1
#=GS A0A6P3RIV1_PTEVA/1092-1252 AC A0A6P3RIV1.1
#=GS A0A6J3E726_AYTFU/788-972 AC A0A6J3E726.1
#=GS A0A1S3AH60_ERIEU/164-334 AC A0A1S3AH60.1
#=GS A0A8I3QBY1_CANLF/1285-1455 AC A0A8I3QBY1.1
#=GS A0A667H0M4_LYNCA/244-424 AC A0A667H0M4.1
#=GS A0A452GNX4_9SAUR/124-300 AC A0A452GNX4.1
#=GS A0A7K8QJ68_9PASS/118-292 AC A0A7K8QJ68.1
#=GS A0A8C6Q904_NOTFU/75-266 AC A0A8C6Q904.1
#=GS F6Q0Q9_MACMU/245-419 AC F6Q0Q9.3
#=GS A0A673GFZ9_9TELE/346-532 AC A0A673GFZ9.1
#=GS A0A7K6BLY7_PTIVI/1-74 AC A0A7K6BLY7.1
#=GS A0A7P0T958_HUMAN/694-882 AC A0A7P0T958.1
#=GS K7F6B5_PELSI/1-165 AC K7F6B5.1
#=GS A0A7K8JJ65_9GRUI/558-749 AC A0A7K8JJ65.1
#=GS A0A674N4T6_TAKRU/198-370 AC A0A674N4T6.1
#=GS A0A6J3GD91_SAPAP/187-365 AC A0A6J3GD91.1
#=GS A0A8C6TPA2_9GOBI/244-424 AC A0A8C6TPA2.1
#=GS H3DF12_TETNG/1-96 AC H3DF12.1
#=GS A0A8C9EYI0_PAVCR/523-697 AC A0A8C9EYI0.1
#=GS A0A7E6D102_9CHIR/107-285 AC A0A7E6D102.1
#=GS A0A6J2IYJ6_9PASS/1308-1488 AC A0A6J2IYJ6.1
#=GS A0A1S3LJF8_SALSA/4-63 AC A0A1S3LJF8.1
#=GS A0A1D5QRW8_MACMU/1287-1457 AC A0A1D5QRW8.2
#=GS A0A4W6G9Q7_LATCA/38-225 AC A0A4W6G9Q7.1
#=GS A0A8C9CA64_PHOSS/1090-1250 AC A0A8C9CA64.1
#=GS A0A4R0RJY1_9APHY/258-440 AC A0A4R0RJY1.1
#=GS A0A673N2E1_9TELE/140-206 AC A0A673N2E1.1
#=GS A0A1B9GYB8_9TREE/672-841 AC A0A1B9GYB8.1
#=GS A0A3B5QFI1_XIPMA/743-921 AC A0A3B5QFI1.1
#=GS A0A093NGT0_PYGAD/1175-1355 AC A0A093NGT0.1
#=GS A0A8C3MP16_GEOPR/1274-1444 AC A0A8C3MP16.1
#=GS A0A2K5YDA6_MANLE/456-639 AC A0A2K5YDA6.1
#=GS A0A0M9A580_9HYME/77-236 AC A0A0M9A580.1
#=GS A0A668VLP6_OREAU/215-393 AC A0A668VLP6.1
#=GS A0A8B9BAB2_9AVES/106-284 AC A0A8B9BAB2.1
#=GS A0A6P8IXP4_ACTTE/134-317 AC A0A6P8IXP4.1
#=GS A0A6P6R2U9_CARAU/1290-1461 AC A0A6P6R2U9.1
#=GS A0A485PCW9_LYNPA/451-642 AC A0A485PCW9.1
#=GS A0A663N167_ATHCN/105-296 AC A0A663N167.1
#=GS A0A8C4LHH6_EQUAS/1204-1357 AC A0A8C4LHH6.1
#=GS A0A670YWT3_PSETE/52-234 AC A0A670YWT3.1
#=GS A0A6J2GBY8_9PASS/1121-1309 AC A0A6J2GBY8.2
#=GS A0A8V1ADG3_CHICK/157-344 AC A0A8V1ADG3.1
#=GS A0A8B6BYV0_MYTGA/497-686 AC A0A8B6BYV0.1
#=GS A0A7J8E2C8_MOLMO/1168-1348 AC A0A7J8E2C8.1
#=GS A0A8J2MGF8_9HEXA/306-449 AC A0A8J2MGF8.1
#=GS A0A8V1AEV8_CHICK/53-240 AC A0A8V1AEV8.1
#=GS A0A3Q3VYZ3_MOLML/187-360 AC A0A3Q3VYZ3.1
#=GS A0A0N4WZY5_HAEPC/57-146 AC A0A0N4WZY5.1
#=GS A0A8C5INU8_JUNHY/1013-1182 AC A0A8C5INU8.1
#=GS A0A3P8X852_ESOLU/2185-2363 AC A0A3P8X852.2
#=GS A0A4W5PS20_9TELE/536-710 AC A0A4W5PS20.1
#=GS X6MIH7_RETFI/57-114 AC X6MIH7.1
#=GS A0A6P8WRI4_DROAB/1442-1630 AC A0A6P8WRI4.1
#=GS A0A665U888_ECHNA/957-1141 AC A0A665U888.1
#=GS A0A3Q1B433_AMPOC/1307-1487 AC A0A3Q1B433.1
#=GS A0A8B7DVV4_HYDVU/476-658 AC A0A8B7DVV4.1
#=GS A0A3Q7SVL6_VULVU/450-628 AC A0A3Q7SVL6.1
#=GS A0A1Y2ITS9_PYCCO/793-865 AC A0A1Y2ITS9.1
#=GS A0A3Q2DKZ3_CYPVA/594-768 AC A0A3Q2DKZ3.1
#=GS A0A851EYZ3_PITSO/1-107 AC A0A851EYZ3.1
#=GS A0A671EYE6_RHIFE/13-64 AC A0A671EYE6.1
#=GS A0A8R2NPI8_ACYPI/166-349 AC A0A8R2NPI8.1
#=GS U3ISK0_ANAPP/210-388 AC U3ISK0.2
#=GS A0A087V6I9_BALRE/13-182 AC A0A087V6I9.1
#=GS A0A2K5ZBG3_MANLE/161-329 AC A0A2K5ZBG3.1
#=GS A0A8I3NC65_CANLF/381-572 AC A0A8I3NC65.1
#=GS A0A8C7ZVL2_9TELE/737-928 AC A0A8C7ZVL2.1
#=GS A0A8C6TYD1_9GOBI/185-354 AC A0A8C6TYD1.1
#=GS A0A674KDX8_TERCA/1613-1804 AC A0A674KDX8.1
#=GS A0A2Y9MQ26_DELLE/1285-1455 AC A0A2Y9MQ26.1
#=GS G1LQY3_AILME/296-477 AC G1LQY3.2
#=GS A0A3B1ITV7_ASTMX/79-250 AC A0A3B1ITV7.1
#=GS A0A7K9J9D2_9CORV/216-407 AC A0A7K9J9D2.1
#=GS A0A8D0BBV4_SALMN/1342-1524 AC A0A8D0BBV4.1
#=GS A0A6J3A1Q2_VICPA/245-419 AC A0A6J3A1Q2.1
#=GS A0A4W2BM31_BOBOX/95-282 AC A0A4W2BM31.1
#=GS A0A852P2B1_9PASS/164-338 AC A0A852P2B1.1
#=GS A0A6J2AKJ2_ACIJB/1057-1213 AC A0A6J2AKJ2.1
#=GS A0A4Q9Q707_9APHY/102-290 AC A0A4Q9Q707.1
#=GS A0A671PWI7_9TELE/574-748 AC A0A671PWI7.1
#=GS A0A674GMS6_TAEGU/32-217 AC A0A674GMS6.1
#=GS A0A3Q7R327_VULVU/1185-1365 AC A0A3Q7R327.1
#=GS A0A4W6CVM8_LATCA/212-403 AC A0A4W6CVM8.1
#=GS A0A7L0N4G7_9PASS/82-267 AC A0A7L0N4G7.1
#=GS A0A8C0EYA4_BUBBB/269-438 AC A0A8C0EYA4.1
#=GS A0A3Q4HFQ8_NEOBR/182-347 AC A0A3Q4HFQ8.1
#=GS A0A7L1HQW0_9CHAR/152-332 AC A0A7L1HQW0.1
#=GS A0A2Y9MN32_DELLE/117-295 AC A0A2Y9MN32.1
#=GS A0A060SKW4_PYCCI/508-675 AC A0A060SKW4.1
#=GS A0A7L0RGW4_GLABR/581-752 AC A0A7L0RGW4.1
#=GS A0A7L2KYR8_9PASS/185-363 AC A0A7L2KYR8.1
#=GS A0A8C6TDF5_9GOBI/98-270 AC A0A8C6TDF5.1
#=GS A0A8C6L4U1_NOTFU/127-303 AC A0A8C6L4U1.1
#=GS Q498M6_RAT/124-300 AC Q498M6.1
#=GS A0A836ED32_9HYME/268-449 AC A0A836ED32.1
#=GS A0A556TKT0_BAGYA/1795-1969 AC A0A556TKT0.1
#=GS A0A8C8Y7L5_PANLE/1967-2158 AC A0A8C8Y7L5.1
#=GS A0A8C8ZQ94_PROSS/1916-2085 AC A0A8C8ZQ94.1
#=GS A0A7J7XXN7_MYOMY/538-727 AC A0A7J7XXN7.1
#=GS A0A663N4R7_ATHCN/1853-2022 AC A0A663N4R7.1
#=GS W5NFK4_LEPOC/183-362 AC W5NFK4.1
#=GS A0A7L3WZR3_9GRUI/1-124 AC A0A7L3WZR3.1
#=GS A0A8C6NR49_NOTFU/23-207 AC A0A8C6NR49.1
#=GS A0A3Q7QSK6_CALUR/1285-1455 AC A0A3Q7QSK6.1
#=GS A0A0C4EJN7_PUCT1/524-714 AC A0A0C4EJN7.1
#=GS A0A852MT66_9PASS/171-345 AC A0A852MT66.1
#=GS A0A6P6DU35_OCTDE/4124-4302 AC A0A6P6DU35.1
#=GS A0A8C9L9W1_PAVCR/755-932 AC A0A8C9L9W1.1
#=GS A0A803W5L5_FICAL/296-477 AC A0A803W5L5.1
#=GS A0A7N9B0S9_9TELE/169-350 AC A0A7N9B0S9.1
#=GS A0A7R9LM70_9ACAR/230-361 AC A0A7R9LM70.1
#=GS A0A7K8T836_9AVES/2-157 AC A0A7K8T836.1
#=GS A0A444UL91_ACIRT/27-211 AC A0A444UL91.1
#=GS A0A5C3LCX8_9AGAR/747-810 AC A0A5C3LCX8.1
#=GS A0A2B4REN0_STYPI/57-236 AC A0A2B4REN0.1
#=GS A0A7L2TZZ0_BALRX/107-285 AC A0A7L2TZZ0.1
#=GS A0A4U0W750_9BASI/387-569 AC A0A4U0W750.1
#=GS A0A8C5I5L6_9TELE/535-720 AC A0A8C5I5L6.1
#=GS A0A1A6GFE2_NEOLE/298-480 AC A0A1A6GFE2.1
#=GS A0A8C7CJ49_ONCKI/253-431 AC A0A8C7CJ49.1
#=GS A0A1Y2F091_PROLT/199-367 AC A0A1Y2F091.1
#=GS H0W1L8_CAVPO/604-778 AC H0W1L8.2
#=GS A0A6I9IIK6_VICPA/211-388 AC A0A6I9IIK6.1
#=GS A0A8J2HN80_COTCN/1745-1920 AC A0A8J2HN80.1
#=GS A0A7N8WVD2_9TELE/434-618 AC A0A7N8WVD2.1
#=GS A0A7M7HAB9_NASVI/605-777 AC A0A7M7HAB9.1
#=GS A0A8J0TP78_XENLA/162-334 AC A0A8J0TP78.1
#=GS A0A6J2R8P1_COTGO/1304-1473 AC A0A6J2R8P1.1
#=GS A0A8C5IU60_JUNHY/1008-1177 AC A0A8C5IU60.1
#=GS A0A1Y2D5E8_9FUNG/50-234 AC A0A1Y2D5E8.1
#=GS A0A6J0XER9_ODOVR/1170-1350 AC A0A6J0XER9.1
#=GS A0A8B9GC89_9PSIT/1060-1240 AC A0A8B9GC89.1
#=GS A0A7K9FGZ4_STEPR/82-267 AC A0A7K9FGZ4.1
#=GS A0A7K8T0W0_9AVES/190-363 AC A0A7K8T0W0.1
#=GS A0A0L8GC65_OCTBM/1-96 AC A0A0L8GC65.1
#=GS A0A7N5JX14_AILME/58-245 AC A0A7N5JX14.1
#=GS A0A8C5BVQ3_GADMO/1116-1296 AC A0A8C5BVQ3.1
#=GS G3QRS6_GORGO/106-288 AC G3QRS6.2
#=GS A0A6J3GFC9_SAPAP/790-973 AC A0A6J3GFC9.1
#=GS A0A8H5FWF5_9AGAR/219-388 AC A0A8H5FWF5.1
#=GS A0A667J381_LYNCA/431-622 AC A0A667J381.1
#=GS H2UU94_TAKRU/771-925 AC H2UU94.3
#=GS A0A8C9EMC1_PAVCR/460-638 AC A0A8C9EMC1.1
#=GS A0A8H5MN10_9HYPO/1256-1467 AC A0A8H5MN10.1
#=GS A0A673GLV5_9TELE/822-1013 AC A0A673GLV5.1
#=GS A0A5N4DBI0_CAMDR/318-496 AC A0A5N4DBI0.1
#=GS A0A3B5QID2_XIPMA/28-210 AC A0A3B5QID2.1
#=GS A0A7K5X409_9CHAR/127-303 AC A0A7K5X409.1
#=GS A0A6I9MVS6_9TELE/118-288 AC A0A6I9MVS6.1
#=GS G1SJX4_RABIT/153-333 AC G1SJX4.2
#=GS A0A6I8UW48_DROPS/163-334 AC A0A6I8UW48.1
#=GS A0A6P4XW71_BRABE/182-355 AC A0A6P4XW71.1
#=GS A0A673ISZ6_9TELE/455-638 AC A0A673ISZ6.1
#=GS A0A2K5K929_COLAP/247-427 AC A0A2K5K929.1
#=GS A0A6J0B4V2_NEOLC/649-831 AC A0A6J0B4V2.1
#=GS A0A6J2WFE9_CHACN/634-842 AC A0A6J2WFE9.1
#=GS FGD3_MOUSE/157-335 AC O88842.1
#=GS A0A401PM96_SCYTO/942-1032 AC A0A401PM96.1
#=GS J4IAC0_9APHY/675-859 AC J4IAC0.1
#=GS A0A8B9W0P2_BOSMU/1044-1232 AC A0A8B9W0P2.1
#=GS A0A7K8RZD1_9PASS/1-74 AC A0A7K8RZD1.1
#=GS A0A8C3MHX7_GEOPR/752-937 AC A0A8C3MHX7.1
#=GS H2PF73_PONAB/1973-2143 AC H2PF73.2
#=GS A0A8C4F283_DICLA/1062-1242 AC A0A8C4F283.2
#=GS G1MW19_MELGA/38-217 AC G1MW19.3
#=GS A0A4Q9NBT6_9APHY/1619-1794 AC A0A4Q9NBT6.1
#=GS A0A663FHD8_AQUCH/22-163 AC A0A663FHD8.1
#=GS A0A2I1G8G3_9GLOM/1723-1899 AC A0A2I1G8G3.1
#=GS A0A091DPS4_FUKDA/666-848 AC A0A091DPS4.1
#=GS A0A8C7LX10_ONCKI/5-80 AC A0A8C7LX10.1
#=GS A0A7J7ARM1_9COLE/628-808 AC A0A7J7ARM1.1
#=GS A0A1I7VDK9_LOALO/248-434 AC A0A1I7VDK9.1
#=GS A0A8C5SV95_LATLA/254-428 AC A0A8C5SV95.1
#=GS A0A8J5B1D3_9DIPT/397-599 AC A0A8J5B1D3.1
#=GS A0A667XY43_9TELE/104-281 AC A0A667XY43.1
#=GS A0A6J1Z4F6_ACIJB/1557-1657 AC A0A6J1Z4F6.1
#=GS A0A6P6NLX2_CARAU/93-280 AC A0A6P6NLX2.1
#=GS A0A4W6C8T1_LATCA/49-225 AC A0A4W6C8T1.1
#=GS A0A498NDL5_LABRO/983-1166 AC A0A498NDL5.1
#=GS A0A673WMM9_SALTR/724-908 AC A0A673WMM9.1
#=GS A0A7K4XAE7_REGSA/565-756 AC A0A7K4XAE7.1
#=GS A0A0D8XUD9_DICVI/284-436 AC A0A0D8XUD9.1
#=GS A0A2K6T0Z6_SAIBB/576-750 AC A0A2K6T0Z6.1
#=GS A0A0V0XXF3_TRIPS/38-220 AC A0A0V0XXF3.1
#=GS A0A3P7J6X7_STRVU/96-273 AC A0A3P7J6X7.1
#=GS A0A3Q2D428_CYPVA/696-879 AC A0A3Q2D428.1
#=GS A0A8J6FVC9_ELECQ/413-591 AC A0A8J6FVC9.1
#=GS A0A852BC93_9CORV/15-184 AC A0A852BC93.1
#=GS A0A484CT21_PERFV/245-436 AC A0A484CT21.1
#=GS A0A8C9GF57_9PRIM/1999-2190 AC A0A8C9GF57.1
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