#=GF ID Roc
#=GF AC PF08477.17
#=GF DE Ras of Complex, Roc, domain of DAPkinase
#=GF PI Miro;
#=GF AU Fenech M;0000-0001-7933-4617
#=GF SE Pfam-B_1154 (release 17.0)
#=GF GA 27.00 27.00;
#=GF TC 27.00 27.00;
#=GF NC 26.90 26.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0023
#=GF RN [1]
#=GF RM 14654223
#=GF RT Roc, a Ras/GTPase domain in complex proteins.
#=GF RA Bosgraaf L, Van Haastert PJ;
#=GF RL Biochim Biophys Acta. 2003;1643:5-10.
#=GF RN [2]
#=GF RM 12482879
#=GF RT Atypical Rho GTPases have roles in mitochondrial homeostasis and
#=GF RT apoptosis.
#=GF RA Fransson A, Ruusala A, Aspenstrom P;
#=GF RL J Biol Chem 2003;278:6495-6502.
#=GF RN [3]
#=GF RM 15479738
#=GF RT Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via
#=GF RT a novel pathway.
#=GF RA Frederick RL, McCaffery JM, Cunningham KW, Okamoto K, Shaw JM;
#=GF RL J Cell Biol. 2004;167:87-98.
#=GF RN [4]
#=GF RM 18650931
#=GF RT Structure of the Roc-COR domain tandem of C. tepidum, a
#=GF RT prokaryotic homologue of the human LRRK2 Parkinson kinase.
#=GF RA Gotthardt K, Weyand M, Kortholt A, Van Haastert PJ, Wittinghofer
#=GF RA A;
#=GF RL EMBO J. 2008;27:2239-2249.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Roc, or Ras of Complex, proteins are mitochondrial Rho proteins
#=GF CC (Miro-1, Swiss:Q8IXI2, and Miro-2, Swiss:Q8IXI1) and atypical
#=GF CC Rho GTPases. Full-length proteins have a unique domain
#=GF CC organisation, with tandem GTP-binding domains and two EF hand
#=GF CC domains (Pfam:PF00036) that may bind calcium. They are also
#=GF CC larger than classical small GTPases. It has been proposed that
#=GF CC they are involved in mitochondrial homeostasis and apoptosis
#=GF CC [1,2,3,4].
#=GF SQ 7991
#=GS A0A6J2G5C3_9PASS/604-724 AC A0A6J2G5C3.1
#=GS A0A8J6GBU8_MICOH/18-85 AC A0A8J6GBU8.1
#=GS A0A7K6DS76_9PASS/1313-1432 AC A0A7K6DS76.1
#=GS A0A8C8GB38_ONCTS/1185-1302 AC A0A8C8GB38.1
#=GS F6UFP4_HORSE/8-128 AC F6UFP4.3
#=GS A0A8C6GW50_MUSSI/5-124 AC A0A8C6GW50.1
#=GS H3CTP9_TETNG/5-119 AC H3CTP9.1
#=GS A0A2K6CSG9_MACNE/23-116 AC A0A2K6CSG9.1
#=GS A0A6P3F7F7_OCTDE/45-112 AC A0A6P3F7F7.1
#=GS A0A7K6Y7N0_ALCTO/8-129 AC A0A7K6Y7N0.1
#=GS A0A2K6R8N0_RHIRO/15-67 AC A0A2K6R8N0.1
#=GS A0A8B8DSC5_CRAVI/671-808 AC A0A8B8DSC5.1
#=GS S9XHC2_CAMFR/7-71 AC S9XHC2.1
#=GS A0A8B6HS33_MYTGA/423-563 AC A0A8B6HS33.1
#=GS A0A7M7P1A8_STRPU/335-419 AC A0A7M7P1A8.1
#=GS A0A8D2D2C5_SCIVU/8-131 AC A0A8D2D2C5.1
#=GS L8HIZ3_ACACA/1100-1234 AC L8HIZ3.1
#=GS A0A7K7IL72_LOXCU/1315-1434 AC A0A7K7IL72.1
#=GS A0A267FUW0_9PLAT/1752-1878 AC A0A267FUW0.1
#=GS A0A2J8V717_PONAB/9-42 AC A0A2J8V717.1
#=GS A0A3P7JA57_STRVU/1-86 AC A0A3P7JA57.1
#=GS Q8YSQ4_NOSS1/5-118 AC Q8YSQ4.1
#=GS A0A804L178_MUSAM/22-141 AC A0A804L178.1
#=GS F2URG9_SALR5/549-666 AC F2URG9.1
#=GS G7YU65_CLOSI/44-111 AC G7YU65.1
#=GS A0A2G5C896_AQUCA/148-252 AC A0A2G5C896.1
#=GS A0A812JV84_9DINO/386-473 AC A0A812JV84.1
#=GS G3PR61_GASAC/17-132 AC G3PR61.1
#=GS A0A8C8EVZ9_ONCTS/5-119 AC A0A8C8EVZ9.1
#=GS A0A835EF09_9POAL/28-144 AC A0A835EF09.1
#=GS A0A139X7R5_9CYAN/384-498 AC A0A139X7R5.1
#=GS Q00ZK8_OSTTA/68-144 AC Q00ZK8.1
#=GS A0A7J8AAH6_PIPKU/8-131 AC A0A7J8AAH6.1
#=GS A0A6I9ZAP2_GEOFO/1258-1377 AC A0A6I9ZAP2.1
#=GS A0A8C8Y6K2_PANLE/1337-1456 AC A0A8C8Y6K2.1
#=GS A0A369S9K2_9METZ/1179-1287 AC A0A369S9K2.1
#=GS A0A6J2GLH2_9PASS/45-111 AC A0A6J2GLH2.1
#=GS A0A7K8BHM0_9CORV/45-111 AC A0A7K8BHM0.1
#=GS A0A830CSH8_9LAMI/86-203 AC A0A830CSH8.1
#=GS A0A7K9HEF3_9AVES/1325-1444 AC A0A7K9HEF3.1
#=GS A0A8B6BRB2_MYTGA/296-414 AC A0A8B6BRB2.1
#=GS A0A672UCG3_STRHB/45-111 AC A0A672UCG3.1
#=GS A0A673XXX6_SALTR/8-130 AC A0A673XXX6.1
#=GS A0A7N8X0B8_9TELE/8-129 AC A0A7N8X0B8.1
#=GS A0A543CG69_9ACTN/363-480 AC A0A543CG69.1
#=GS A0A2P6NF34_9EUKA/40-158 AC A0A2P6NF34.1
#=GS A0A813F552_POLGL/731-845 AC A0A813F552.1
#=GS A0A2R9CJV8_PANPA/14-95 AC A0A2R9CJV8.1
#=GS A0A2P4SP29_BAMTH/5-125 AC A0A2P4SP29.1
#=GS A0A4V3S9P4_9HYME/1147-1256 AC A0A4V3S9P4.1
#=GS A0A0Q3T7M5_AMAAE/5-125 AC A0A0Q3T7M5.1
#=GS A0A098S8X4_9BACT/200-328 AC A0A098S8X4.1
#=GS Q38C89_TRYB2/9-126 AC Q38C89.1
#=GS A0A7E4VDA0_PANRE/1065-1175 AC A0A7E4VDA0.1
#=GS A0A091GMB8_BUCRH/77-196 AC A0A091GMB8.1
#=GS A0A2K5CBB4_AOTNA/23-88 AC A0A2K5CBB4.1
#=GS A0A6P4YQC6_BRABE/184-299 AC A0A6P4YQC6.1
#=GS A0A3Q7QXC9_VULVU/45-111 AC A0A3Q7QXC9.1
#=GS A0A6G0U8J1_APHGL/12-125 AC A0A6G0U8J1.1
#=GS A0A7L3MDY1_9PASS/29-100 AC A0A7L3MDY1.1
#=GS A0A1L8HBZ9_XENLA/8-129 AC A0A1L8HBZ9.1
#=GS A0A8C8DIK9_9TELE/406-519 AC A0A8C8DIK9.1
#=GS A0A7M7MZ72_STRPU/1587-1703 AC A0A7M7MZ72.1
#=GS A0A813P937_ADIRI/1597-1728 AC A0A813P937.1
#=GS A0A8B7BWB5_PHODC/23-142 AC A0A8B7BWB5.1
#=GS A0A7M7MPZ9_APIME/11-64 AC A0A7M7MPZ9.1
#=GS Q4DF14_TRYCC/10-50 AC Q4DF14.1
#=GS A0A2K5Y6R0_MANLE/18-59 AC A0A2K5Y6R0.1
#=GS A0A8B6CB27_MYTGA/279-384 AC A0A8B6CB27.1
#=GS A0A0M3JTB2_ANISI/9-51 AC A0A0M3JTB2.1
#=GS A0A7K9F4Y8_STEPR/7-128 AC A0A7K9F4Y8.1
#=GS I3JDE7_ORENI/634-754 AC I3JDE7.2
#=GS A0A7K8E5B0_LEURO/8-129 AC A0A7K8E5B0.1
#=GS G3UH46_LOXAF/45-111 AC G3UH46.1
#=GS A0A3P8WFW3_CYNSE/43-164 AC A0A3P8WFW3.1
#=GS A0A8B9MR27_9AVES/15-66 AC A0A8B9MR27.1
#=GS A0A1S3J0R0_LINUN/243-361 AC A0A1S3J0R0.1
#=GS A0A667GTH9_LYNCA/1296-1415 AC A0A667GTH9.1
#=GS A0A8C3ZQT8_9TELE/7-45 AC A0A8C3ZQT8.1
#=GS A0A7H1N4S0_9PROT/445-572 AC A0A7H1N4S0.1
#=GS A0A4X2K683_VOMUR/1252-1371 AC A0A4X2K683.1
#=GS A0A674AHD7_SALTR/600-720 AC A0A674AHD7.1
#=GS A0A844MEF1_9CYAN/384-498 AC A0A844MEF1.1
#=GS A0A674GFJ1_TAEGU/1317-1436 AC A0A674GFJ1.1
#=GS A0A3P9CWY4_9CICH/23-89 AC A0A3P9CWY4.1
#=GS F2ULQ5_SALR5/527-641 AC F2ULQ5.1
#=GS A0A2P6RRJ1_ROSCH/24-143 AC A0A2P6RRJ1.1
#=GS A0A2Y9N4Y8_DELLE/1336-1455 AC A0A2Y9N4Y8.2
#=GS Q3SDK5_PARTE/8-132 AC Q3SDK5.1
#=GS R1CLF0_EMIHU/369-489 AC R1CLF0.1
#=GS B4VKC2_9CYAN/386-505 AC B4VKC2.1
#=GS A0A150G430_GONPE/173-288 AC A0A150G430.1
#=GS A0A673SPY0_SURSU/411-540 AC A0A673SPY0.1
#=GS A0A8C3HBE3_CHRPI/1115-1233 AC A0A8C3HBE3.1
#=GS A0A1S3HM91_LINUN/66-120 AC A0A1S3HM91.1
#=GS E2AKZ5_CAMFO/1074-1179 AC E2AKZ5.1
#=GS A0A6P4XHY3_BRABE/3010-3126 AC A0A6P4XHY3.1
#=GS A0A2Y9N9P8_DELLE/1264-1383 AC A0A2Y9N9P8.2
#=GS A0A8C5V588_MICMU/640-760 AC A0A8C5V588.1
#=GS A0A6J0U041_9SAUR/1315-1434 AC A0A6J0U041.1
#=GS A0A663NF32_ATHCN/45-111 AC A0A663NF32.1
#=GS A0A813GFH5_POLGL/29-77 AC A0A813GFH5.1
#=GS A0A1S3HRH2_LINUN/839-953 AC A0A1S3HRH2.1
#=GS A0A2P5WG31_GOSBA/11-57 AC A0A2P5WG31.1
#=GS A2EFD0_TRIV3/5-101 AC A2EFD0.1
#=GS A0A669PB56_PHACC/630-750 AC A0A669PB56.1
#=GS A0A158RC19_THECL/1036-1140 AC A0A158RC19.1
#=GS A0A5C7IQS3_9ROSI/185-297 AC A0A5C7IQS3.1
#=GS A0A8C5HWW9_9TELE/12-125 AC A0A8C5HWW9.1
#=GS A0A0D2T203_GOSRA/90-184 AC A0A0D2T203.1
#=GS A0A2I3T2F5_PANTR/45-111 AC A0A2I3T2F5.1
#=GS G5AU88_HETGA/1-114 AC G5AU88.1
#=GS A0A0A1UAV3_ENTIV/10-122 AC A0A0A1UAV3.1
#=GS A0A8R2D438_ACYPI/41-154 AC A0A8R2D438.1
#=GS H0YYY0_TAEGU/1302-1421 AC H0YYY0.2
#=GS A0A5A9PDU8_9TELE/393-509 AC A0A5A9PDU8.1
#=GS A0A168JUU4_MUCCL/47-112 AC A0A168JUU4.1
#=GS A0A2I3GF38_NOMLE/8-128 AC A0A2I3GF38.1
#=GS A0A1S3NVP7_SALSA/8-127 AC A0A1S3NVP7.1
#=GS A0A1S3JBV3_LINUN/329-447 AC A0A1S3JBV3.1
#=GS A0A8B8D706_CRAVI/2571-2689 AC A0A8B8D706.1
#=GS A0A7L1VSZ6_9PASS/660-780 AC A0A7L1VSZ6.1
#=GS A0A6P6NW64_CARAU/46-115 AC A0A6P6NW64.1
#=GS V8N0D0_OPHHA/14-70 AC V8N0D0.1
#=GS D7M287_ARALL/24-144 AC D7M287.1
#=GS A0A8B7BWB2_PHODC/23-142 AC A0A8B7BWB2.1
#=GS A0A674HIX9_TAEGU/1306-1425 AC A0A674HIX9.1
#=GS A0A2K5P959_CEBIM/45-111 AC A0A2K5P959.1
#=GS A0A182YEY4_ANOST/1052-1196 AC A0A182YEY4.1
#=GS A0A444X525_ARAHY/23-143 AC A0A444X525.1
#=GS A0A6J1SYG8_FRAOC/5-126 AC A0A6J1SYG8.1
#=GS A0A8B7ZDX2_ACAPL/5-126 AC A0A8B7ZDX2.1
#=GS A0DMK2_PARTE/23-137 AC A0DMK2.1
#=GS A0A671P0M8_9TELE/18-134 AC A0A671P0M8.1
#=GS F2USQ8_SALR5/585-701 AC F2USQ8.1
#=GS A0A8I6B1B9_RAT/613-733 AC A0A8I6B1B9.1
#=GS A0A8D2IBE0_UROPR/8-128 AC A0A8D2IBE0.1
#=GS G1RA41_NOMLE/5-81 AC G1RA41.2
#=GS A0A6J8ATM3_MYTCO/59-152 AC A0A6J8ATM3.1
#=GS A0A8B7DZR5_HYDVU/1-111 AC A0A8B7DZR5.1
#=GS A0A7K8AKU4_9CORV/1325-1444 AC A0A7K8AKU4.1
#=GS H0WT11_OTOGA/1-114 AC H0WT11.1
#=GS K9W0B0_9CYAN/380-493 AC K9W0B0.1
#=GS A0A6J0CK44_PERMB/1335-1454 AC A0A6J0CK44.1
#=GS F2UN94_SALR5/390-524 AC F2UN94.1
#=GS A0A444V262_ACIRT/269-389 AC A0A444V262.1
#=GS A0A813ZUH9_9BILA/7-128 AC A0A813ZUH9.1
#=GS A0A7L3VCL4_MOLAT/1316-1435 AC A0A7L3VCL4.1
#=GS A0A8C3WDH5_9CETA/641-761 AC A0A8C3WDH5.1
#=GS A0A8C6UUF2_9GOBI/27-140 AC A0A8C6UUF2.1
#=GS A0A3G3GI78_9BACT/259-374 AC A0A3G3GI78.1
#=GS A0A7J7DU29_TRIWF/11-55 AC A0A7J7DU29.1
#=GS A0A495E5L6_9FLAO/364-478 AC A0A495E5L6.1
#=GS A0A834N929_VESVU/8-119 AC A0A834N929.1
#=GS A0A1I1DKX3_9BACT/311-434 AC A0A1I1DKX3.1
#=GS A0A8B9DXU9_ANSCY/45-111 AC A0A8B9DXU9.1
#=GS A0A821MYZ7_9NEOP/52-104 AC A0A821MYZ7.1
#=GS A0A836J0B2_9ROSI/12-128 AC A0A836J0B2.1
#=GS B3N0D1_DROAN/6-117 AC B3N0D1.1
#=GS H5Y3V6_9FIRM/457-584 AC H5Y3V6.1
#=GS A0A6A2ZS58_HIBSY/23-145 AC A0A6A2ZS58.1
#=GS U3IYL7_ANAPP/1342-1461 AC U3IYL7.2
#=GS F6W350_CIOIN/47-120 AC F6W350.2
#=GS A0A672GDB8_SALFA/14-89 AC A0A672GDB8.1
#=GS A0A2K6R5W7_RHIRO/1336-1455 AC A0A2K6R5W7.1
#=GS A0A3P8UHQ8_AMPPE/5-124 AC A0A3P8UHQ8.1
#=GS A0A6J8DRC5_MYTCO/22-126 AC A0A6J8DRC5.1
#=GS A0A1X0NRS7_9TRYP/7-132 AC A0A1X0NRS7.1
#=GS A0A8C2YZ23_CYCLU/45-111 AC A0A8C2YZ23.1
#=GS A0A6J3JJ22_SAPAP/8-129 AC A0A6J3JJ22.1
#=GS A0A8A4TW59_9BACT/102-212 AC A0A8A4TW59.1
#=GS A0A7L2K7G9_9PASS/45-111 AC A0A7L2K7G9.1
#=GS A7SHA4_NEMVE/44-114 AC A7SHA4.1
#=GS A0A7K4TN24_9SYLV/1325-1444 AC A0A7K4TN24.1
#=GS A0A7M5WXZ0_9CNID/1421-1543 AC A0A7M5WXZ0.1
#=GS A0A8C4U061_FALTI/1295-1414 AC A0A8C4U061.1
#=GS A0A8B8CSB4_CRAVI/374-486 AC A0A8B8CSB4.1
#=GS A0A7E6EH86_OCTVU/304-427 AC A0A7E6EH86.1
#=GS A0A2K6USE4_SAIBB/9-42 AC A0A2K6USE4.1
#=GS A0A803W2P2_FICAL/1241-1360 AC A0A803W2P2.1
#=GS A0A0R3WSK3_HYDTA/8-138 AC A0A0R3WSK3.1
#=GS A0A087RKP0_APTFO/1287-1406 AC A0A087RKP0.1
#=GS A0A8C8D8Z5_ONCTS/8-78 AC A0A8C8D8Z5.1
#=GS A0A850U9K1_GRUAM/418-458 AC A0A850U9K1.1
#=GS A0A087QKQ6_APTFO/661-781 AC A0A087QKQ6.1
#=GS A0A670J7K0_PODMU/1299-1418 AC A0A670J7K0.1
#=GS A0A2K6UR05_SAIBB/23-99 AC A0A2K6UR05.1
#=GS A0A7C9BFM8_9BACT/234-333 AC A0A7C9BFM8.1
#=GS A0A8I3MH84_CANLF/626-746 AC A0A8I3MH84.1
#=GS A0A7J7QZC2_MYOMY/45-111 AC A0A7J7QZC2.1
#=GS A0A7J5XKU8_DISMA/18-96 AC A0A7J5XKU8.1
#=GS A0A091VBX2_OPIHO/1-115 AC A0A091VBX2.1
#=GS A0A0L8HQY5_OCTBM/1373-1489 AC A0A0L8HQY5.1
#=GS A0A7K6CK87_PTIVI/652-772 AC A0A7K6CK87.1
#=GS A0A851KFU1_VIDCH/1314-1433 AC A0A851KFU1.1
#=GS A0A7K6KUE6_9CORV/660-780 AC A0A7K6KUE6.1
#=GS A0A218UHE7_9PASE/1339-1458 AC A0A218UHE7.1
#=GS A0A6I9W921_BACDO/982-1091 AC A0A6I9W921.1
#=GS A0A212CSK3_CEREH/290-408 AC A0A212CSK3.1
#=GS A0A8K1FS67_PYTOL/159-301 AC A0A8K1FS67.1
#=GS A0A5M9JA09_MONFR/11-62 AC A0A5M9JA09.1
#=GS A0A3P9DFK9_9CICH/5-124 AC A0A3P9DFK9.1
#=GS A0A8C0Y6N7_CYPCA/15-100 AC A0A8C0Y6N7.1
#=GS A0A452QNQ6_URSAM/14-88 AC A0A452QNQ6.1
#=GS A0A2P8ZE40_BLAGE/53-164 AC A0A2P8ZE40.1
#=GS A0A851W3B8_CORMO/1313-1432 AC A0A851W3B8.1
#=GS A0A7L0VFC7_9PASE/1-115 AC A0A7L0VFC7.1
#=GS A0A250XVW4_CASCN/5-124 AC A0A250XVW4.1
#=GS A0A7E4V2K9_PANRE/12-130 AC A0A7E4V2K9.1
#=GS A0A150FYE2_GONPE/74-187 AC A0A150FYE2.1
#=GS A0A093EKQ0_TAUER/665-785 AC A0A093EKQ0.1
#=GS A0A2K5LWJ1_CERAT/8-128 AC A0A2K5LWJ1.1
#=GS A0A3L6S6X6_PANMI/28-143 AC A0A3L6S6X6.1
#=GS A0A8B6BPY8_MYTGA/202-292 AC A0A8B6BPY8.1
#=GS A0A2U4ABR1_TURTR/8-128 AC A0A2U4ABR1.1
#=GS B7QGJ2_IXOSC/1019-1133 AC B7QGJ2.1
#=GS V4ANL8_LOTGI/375-490 AC V4ANL8.1
#=GS A0A7K5JPD0_9TYRA/8-129 AC A0A7K5JPD0.1
#=GS A0A4V6XVX1_STECR/5-124 AC A0A4V6XVX1.1
#=GS A0A663LJK1_ATHCN/1247-1366 AC A0A663LJK1.1
#=GS A0A8D2KKV5_UROPR/413-542 AC A0A8D2KKV5.1
#=GS A0A8C8VP56_9SAUR/1304-1423 AC A0A8C8VP56.1
#=GS A0A3Q2VFP9_HAPBU/214-331 AC A0A3Q2VFP9.1
#=GS A0A8R1YGS0_PRIPA/22-137 AC A0A8R1YGS0.1
#=GS A0A8K0GL12_9COLE/48-114 AC A0A8K0GL12.1
#=GS A0A8B6CWV9_MYTGA/505-636 AC A0A8B6CWV9.1
#=GS A0A6P4Z5W5_BRABE/304-432 AC A0A6P4Z5W5.1
#=GS F2TWV0_SALR5/1068-1179 AC F2TWV0.1
#=GS A0A8C8GFT1_ONCTS/1126-1243 AC A0A8C8GFT1.1
#=GS Q7Q5M9_ANOGA/8-118 AC Q7Q5M9.4
#=GS A0A8B8DPY6_CRAVI/671-809 AC A0A8B8DPY6.1
#=GS A0A091R9R3_MERNU/1-115 AC A0A091R9R3.1
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