#=GF ID SAMD1_SHD
#=GF AC PF24971.1
#=GF DE SAMD1 small helical domain
#=GF AU Andreeva A;0000-0002-0450-0091
#=GF SE Manual
#=GF GA 27.00 27.00;
#=GF TC 28.80 27.30;
#=GF NC 26.70 25.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 8 -Z 81514348 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 33980486
#=GF RT The SAM domain-containing protein 1 (SAMD1) acts as a repressive
#=GF RT chromatin regulator at unmethylated CpG islands.
#=GF RA Stielow B, Zhou Y, Cao Y, Simon C, Pogoda HM, Jiang J, Ren Y,
#=GF RA Phanor SK, Rohner I, Nist A, Stiewe T, Hammerschmidt M, Shi Y,
#=GF RA Bulyk ML, Wang Z, Liefke R;
#=GF RL Sci Adv. 2021; [Epub ahead of print]
#=GF RN [2]
#=GF RM 34006929
#=GF RT The miR-378c-Samd1 circuit promotes phenotypic modulation of
#=GF RT vascular smooth muscle cells and foam cells formation in
#=GF RT atherosclerosis lesions.
#=GF RA Tian S, Cao Y, Wang J, Bi Y, Zhong J, Meng X, Sun W, Yang R, Gan
#=GF RA L, Wang X, Li H, Wang R;
#=GF RL Sci Rep. 2021;11:10548.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found in the human Sterile alpha motif
#=GF CC domain-containing protein 1 (SAMD1) and related proteins. SAMD1
#=GF CC directly recognizes and binds unmethylated CpG-containing DNA
#=GF CC via simultaneous interactions with both the major and the minor
#=GF CC groove [1]. SAMD1 acts as a transcriptional repressor and
#=GF CC chromatin regulator [1,2].
#=GF SQ 189
#=GS A0A670Y965_PSETE/133-198 AC A0A670Y965.1
#=GS A0A8C6PA17_NOTFU/289-371 AC A0A8C6PA17.1
#=GS A0A9J7ZLD9_CYPCA/289-363 AC A0A9J7ZLD9.1
#=GS A0A8C4PQ49_EQUAS/221-288 AC A0A8C4PQ49.2
#=GS A0A2Y9L902_ENHLU/241-320 AC A0A2Y9L902.1
#=GS A0A8C6R799_NANGA/109-157 AC A0A8C6R799.1
#=GS A0A8J4U8E2_CLAMG/218-309 AC A0A8J4U8E2.1
#=GS A0A096M7W4_POEFO/287-368 AC A0A096M7W4.1
#=GS A0A811Z9X8_NYCPR/246-325 AC A0A811Z9X8.1
#=GS W5MUY9_LEPOC/295-369 AC W5MUY9.1
#=GS A0A6P9B4W8_PANGU/154-239 AC A0A6P9B4W8.1
#=GS A0A674JHB9_TERCA/163-242 AC A0A674JHB9.1
#=GS F7CUZ4_MONDO/152-233 AC F7CUZ4.3
#=GS A0A2U9BQW2_SCOMX/204-284 AC A0A2U9BQW2.1
#=GS A0A8J6DVF5_GALPY/238-317 AC A0A8J6DVF5.1
#=GS A0A6J3GVQ3_SAPAP/126-205 AC A0A6J3GVQ3.1
#=GS A0A3Q3M1U2_9TELE/301-382 AC A0A3Q3M1U2.1
#=GS A0A484DLU4_PERFV/199-280 AC A0A484DLU4.1
#=GS A0A2K5F0P0_AOTNA/128-207 AC A0A2K5F0P0.1
#=GS A0A8D2JSU4_SCIVU/132-211 AC A0A8D2JSU4.1
#=GS A0A3Q1N125_BOVIN/236-315 AC A0A3Q1N125.1
#=GS A0A8C0K0X2_CANLU/237-316 AC A0A8C0K0X2.1
#=GS A0A674A928_SALTR/395-478 AC A0A674A928.1
#=GS A0A2I4CN88_AUSLI/262-341 AC A0A2I4CN88.1
#=GS A0A1A6H8K3_NEOLE/67-145 AC A0A1A6H8K3.1
#=GS A0A6F9C7I0_9TELE/337-420 AC A0A6F9C7I0.1
#=GS A0A2R8M4H5_CALJA/132-211 AC A0A2R8M4H5.3
#=GS SAMD1_HUMAN/239-318 AC Q6SPF0.1
#=GS A0A8C4WKV9_9SAUR/130-212 AC A0A8C4WKV9.1
#=GS A0A2K5S740_CEBIM/90-169 AC A0A2K5S740.1
#=GS A0A8T3CVS5_9TELE/301-375 AC A0A8T3CVS5.1
#=GS A0A8T0AD49_SILME/252-341 AC A0A8T0AD49.1
#=GS A0A7J7TAJ1_PIPKU/239-318 AC A0A7J7TAJ1.1
#=GS A0A8C8Y7W2_PANLE/126-205 AC A0A8C8Y7W2.1
#=GS A0A4X2M625_VOMUR/121-202 AC A0A4X2M625.1
#=GS M4AD05_XIPMA/280-361 AC M4AD05.1
#=GS A0A498NVL1_LABRO/291-365 AC A0A498NVL1.1
#=GS A0A3P8SEG9_AMPPE/120-199 AC A0A3P8SEG9.1
#=GS A0A556TL74_BAGYA/245-321 AC A0A556TL74.1
#=GS A0A8T2NHX4_9TELE/348-422 AC A0A8T2NHX4.1
#=GS A0A2K6AV38_MACNE/90-169 AC A0A2K6AV38.1
#=GS A0A6P6KB20_CARAU/287-361 AC A0A6P6KB20.1
#=GS A0A6G0JB93_LARCR/320-401 AC A0A6G0JB93.1
#=GS A0A671EPA5_RHIFE/132-211 AC A0A671EPA5.1
#=GS A0A9B0X063_CHRAS/78-157 AC A0A9B0X063.1
#=GS A0A6J2MF47_9CHIR/241-316 AC A0A6J2MF47.1
#=GS A0A8C5BRK9_GADMO/288-366 AC A0A8C5BRK9.1
#=GS A0A2K5U8C5_MACFA/120-199 AC A0A2K5U8C5.2
#=GS A0A4D9DJZ8_9SAUR/160-240 AC A0A4D9DJZ8.1
#=GS A0A8T3CME6_9TELE/290-371 AC A0A8T3CME6.1
#=GS F6T1W0_HORSE/241-320 AC F6T1W0.2
#=GS A0A7J8BV69_ROUAE/237-316 AC A0A7J8BV69.1
#=GS A0A671X8K1_SPAAU/305-386 AC A0A671X8K1.1
#=GS A0A6J1YLN1_ACIJB/102-177 AC A0A6J1YLN1.1
#=GS A0A8M2BB29_DANRE/284-358 AC A0A8M2BB29.1
#=GS A0A3N0Z147_ANAGA/274-348 AC A0A3N0Z147.1
#=GS A0A3Q3FT00_9LABR/305-384 AC A0A3Q3FT00.1
#=GS A0A6I8N4R7_ORNAN/196-280 AC A0A6I8N4R7.1
#=GS A0A9W2WIH6_PHYMC/130-209 AC A0A9W2WIH6.1
#=GS E9PIW9_HUMAN/133-212 AC E9PIW9.1
#=GS A0A9D3S998_9TELE/248-330 AC A0A9D3S998.1
#=GS A0A8J7T8S5_ATRSP/284-359 AC A0A8J7T8S5.1
#=GS A0A452EQ70_CAPHI/236-315 AC A0A452EQ70.1
#=GS A0A8C4M6M3_EQUAS/123-195 AC A0A8C4M6M3.2
#=GS A0A7J7RA88_MYOMY/239-318 AC A0A7J7RA88.1
#=GS A0A2U4AZD4_TURTR/242-321 AC A0A2U4AZD4.2
#=GS W5P992_SHEEP/129-171 AC W5P992.1
#=GS A0A8D2DZX8_SCIVU/238-317 AC A0A8D2DZX8.1
#=GS A0A6P6N2D6_CARAU/285-359 AC A0A6P6N2D6.1
#=GS A0A287A2N4_PIG/227-306 AC A0A287A2N4.3
#=GS A0A3Q3B7Z5_KRYMA/290-372 AC A0A3Q3B7Z5.1
#=GS A0A5E4AA29_MARMO/233-312 AC A0A5E4AA29.1
#=GS A0A669D207_ORENI/303-384 AC A0A669D207.1
#=GS G3Q4V1_GASAC/228-307 AC G3Q4V1.1
#=GS A0A8C0AJX2_BOSMU/232-311 AC A0A8C0AJX2.1
#=GS A0A8M1M7G6_NEOSC/109-188 AC A0A8M1M7G6.1
#=GS A0A7J6DGL0_9TELE/291-365 AC A0A7J6DGL0.1
#=GS H2NXS6_PONAB/228-307 AC H2NXS6.2
#=GS A0A060ZEW0_ONCMY/175-258 AC A0A060ZEW0.1
#=GS A0A9D3LQF9_ANGAN/289-371 AC A0A9D3LQF9.1
#=GS H0Y1N4_OTOGA/1-52 AC H0Y1N4.1
#=GS SAMD1_RABIT/248-327 AC Q6SPE9.1
#=GS A0A8M1FRU4_URSMA/233-312 AC A0A8M1FRU4.1
#=GS A0A8U0TQ90_SALNM/340-421 AC A0A8U0TQ90.1
#=GS A0A4W5MQL0_9TELE/153-236 AC A0A4W5MQL0.1
#=GS A0A452ER51_CAPHI/231-310 AC A0A452ER51.1
#=GS A0A4Z2E2Z0_9TELE/305-388 AC A0A4Z2E2Z0.1
#=GS A0A4U5U4A1_COLLU/313-394 AC A0A4U5U4A1.1
#=GS A0A8P4FWK3_DICLA/307-388 AC A0A8P4FWK3.1
#=GS A0A5F8ACB3_MACMU/238-317 AC A0A5F8ACB3.1
#=GS A0A3Q1LS12_BOVIN/133-212 AC A0A3Q1LS12.1
#=GS A0A6P8W7R1_GYMAC/294-371 AC A0A6P8W7R1.1
#=GS A0A3Q1EVK3_9TELE/299-378 AC A0A3Q1EVK3.1
#=GS A0A8C1FDY2_CYPCA/261-335 AC A0A8C1FDY2.2
#=GS A0A8C2WZR6_CYCLU/303-385 AC A0A8C2WZR6.1
#=GS A0A6J1UVZ4_9SAUR/165-230 AC A0A6J1UVZ4.1
#=GS A0A8C3W3U1_9CETA/238-317 AC A0A8C3W3U1.1
#=GS A0A1S3L486_SALSA/394-477 AC A0A1S3L486.1
#=GS A0A669EWY4_ORENI/303-384 AC A0A669EWY4.1
#=GS A0A8D2J211_VARKO/130-211 AC A0A8D2J211.1
#=GS A0A8C7N018_ONCKI/411-494 AC A0A8C7N018.1
#=GS A0A8C7EMF5_NEOVI/150-209 AC A0A8C7EMF5.1
#=GS A0A1S3QLF4_SALSA/335-418 AC A0A1S3QLF4.1
#=GS A0A9D4AZV5_9SAUR/163-242 AC A0A9D4AZV5.1
#=GS A0A8C9IQH9_9PRIM/137-212 AC A0A8C9IQH9.1
#=GS A0A553QBQ2_9TELE/215-292 AC A0A553QBQ2.1
#=GS A0A4W2F2E6_BOBOX/364-443 AC A0A4W2F2E6.1
#=GS A0A5E4A9T5_MARMO/233-312 AC A0A5E4A9T5.1
#=GS H3AP11_LATCH/204-289 AC H3AP11.1
#=GS A0A9J8B2B9_CYPCA/289-363 AC A0A9J8B2B9.1
#=GS A0A8D2EM84_THEGE/132-211 AC A0A8D2EM84.1
#=GS A0A8D0BBD8_SALMN/124-206 AC A0A8D0BBD8.1
#=GS A0A6J2PM59_COTGO/301-383 AC A0A6J2PM59.1
#=GS A0A2K5NZ79_CERAT/68-147 AC A0A2K5NZ79.1
#=GS A0A3Q2GFL3_CYPVA/252-327 AC A0A3Q2GFL3.1
#=GS A0A6P5KZW9_PHACI/208-289 AC A0A6P5KZW9.1
#=GS A0A3P9MT77_POERE/208-289 AC A0A3P9MT77.1
#=GS A0A498L779_LABRO/291-365 AC A0A498L779.1
#=GS A0A3P9A3N7_ESOLU/332-409 AC A0A3P9A3N7.1
#=GS A0A8C6D7N7_MOSMO/238-317 AC A0A8C6D7N7.1
#=GS A0A672L365_SINGR/280-354 AC A0A672L365.1
#=GS A0A8C9B1M1_PHOSS/240-319 AC A0A8C9B1M1.1
#=GS A0A7J6A0H2_AMEME/253-329 AC A0A7J6A0H2.1
#=GS A0A9D3T4F8_MEGAT/293-374 AC A0A9D3T4F8.1
#=GS A0A7N4V3D1_SARHA/210-291 AC A0A7N4V3D1.1
#=GS A0A452INQ3_9SAUR/126-205 AC A0A452INQ3.1
#=GS A0A8C3WAW8_9CETA/132-211 AC A0A8C3WAW8.1
#=GS A0A8U0V5T0_MUSPF/242-321 AC A0A8U0V5T0.1
#=GS A0A3Q1I5A2_ANATE/292-375 AC A0A3Q1I5A2.1
#=GS A0A6A5FNL3_PERFL/305-386 AC A0A6A5FNL3.1
#=GS A0A8D2HD61_UROPR/228-307 AC A0A8D2HD61.1
#=GS SAMD1_MOUSE/220-298 AC D3YXK1.1
#=GS A0A8C5D7U2_9TELE/219-298 AC A0A8C5D7U2.1
#=GS A0A3Q2VP01_HAPBU/303-384 AC A0A3Q2VP01.1
#=GS A0A4W6DKQ3_LATCA/306-387 AC A0A4W6DKQ3.1
#=GS A0A2K6JVH9_RHIBE/1-50 AC A0A2K6JVH9.1
#=GS A0A4U1EQE4_MONMO/122-201 AC A0A4U1EQE4.1
#=GS A0A7N9IA20_MACFA/194-273 AC A0A7N9IA20.1
#=GS G3SUU8_LOXAF/1-72 AC G3SUU8.1
#=GS A0A8C5VQV0_MICMU/140-203 AC A0A8C5VQV0.1
#=GS A0A2K6F7H4_PROCO/122-201 AC A0A2K6F7H4.1
#=GS A0A6I9P658_9TELE/295-372 AC A0A6I9P658.1
#=GS A0A8C9XKT1_SANLU/304-385 AC A0A8C9XKT1.1
#=GS A0A670K9R3_PODMU/164-247 AC A0A670K9R3.1
#=GS A0A6I9XR28_9SAUR/154-239 AC A0A6I9XR28.1
#=GS A0A6P7IZU4_9TELE/303-384 AC A0A6P7IZU4.1
#=GS A0A7J8IC98_MOLMO/239-318 AC A0A7J8IC98.1
#=GS A0A9D3QIA3_MEGAT/339-413 AC A0A9D3QIA3.1
#=GS A0A340YB76_LIPVE/1-69 AC A0A340YB76.1
#=GS A0A7J5Y3W2_DISMA/346-423 AC A0A7J5Y3W2.1
#=GS A0A8B7TVA3_CASCN/242-321 AC A0A8B7TVA3.1
#=GS A0A8B8WZC6_BALMU/239-318 AC A0A8B8WZC6.1
#=GS A0A6P8F5G6_CLUHA/322-396 AC A0A6P8F5G6.1
#=GS A0A5J5N3A1_MUNRE/28-107 AC A0A5J5N3A1.1
#=GS A0A3Q7PS58_CALUR/101-179 AC A0A3Q7PS58.1
#=GS A0A8I6AKG2_RAT/220-298 AC A0A8I6AKG2.1
#=GS A0A6P8X4R3_GYMAC/294-371 AC A0A6P8X4R3.1
#=GS A0A671ETG5_RHIFE/234-313 AC A0A671ETG5.1
#=GS A0A8X8BYT4_POLSE/321-400 AC A0A8X8BYT4.1
#=GS A0A9D3S8S6_ANGAN/298-373 AC A0A9D3S8S6.1
#=GS A0A553QBP8_9TELE/215-292 AC A0A553QBP8.1
#=GS A0A1S3QJH8_SALSA/335-418 AC A0A1S3QJH8.1
#=GS A0A3Q4G5R8_NEOBR/263-336 AC A0A3Q4G5R8.1
#=GS A0A1U7R7G0_MESAU/1-43 AC A0A1U7R7G0.1
#=GS A0A0D9R232_CHLSB/1-68 AC A0A0D9R232.1
#=GS A0A8C6D2L9_MOSMO/131-210 AC A0A8C6D2L9.1
#=GS A0A5A9PJJ3_9TELE/167-241 AC A0A5A9PJJ3.1
#=GS A0A8J6G2V8_MICOH/358-436 AC A0A8J6G2V8.1
#=GS A0A0A0MWZ2_PAPAN/222-301 AC A0A0A0MWZ2.3
#=GS A0A3Q1DD23_AMPOC/304-383 AC A0A3Q1DD23.1
#=GS A0A673AXW3_9TELE/307-389 AC A0A673AXW3.1
#=GS A0A3P8SEJ9_AMPPE/211-272 AC A0A3P8SEJ9.1
#=GS A0A0N8JUW3_SCLFO/52-119 AC A0A0N8JUW3.1
#=GS A0A5N5JWU3_PANHP/263-342 AC A0A5N5JWU3.1
#=GS A0A672QNJ0_SINGR/287-361 AC A0A672QNJ0.1
#=GS A0A8I3PXF9_CANLF/237-316 AC A0A8I3PXF9.1
#=GS A0A6G1PAQ7_9TELE/302-383 AC A0A6G1PAQ7.1
#=GS A0A7N4PVQ5_SARHA/210-291 AC A0A7N4PVQ5.1
#=GS H2R2Z5_PANTR/104-184 AC H2R2Z5.2
#=GS A0A665WAH0_ECHNA/308-387 AC A0A665WAH0.1
#=GS A0A6J2VWL1_CHACN/304-378 AC A0A6J2VWL1.1
#=GS A0A6P6PC04_CARAU/286-360 AC A0A6P6PC04.1
#=GS A0A2Y9LXH6_DELLE/33-112 AC A0A2Y9LXH6.1
#=GS A0A8C4G4L7_9TELE/201-285 AC A0A8C4G4L7.1
#=GS A0A4W4H929_ELEEL/303-377 AC A0A4W4H929.1
#=GS A0A8C4T0J3_ERPCA/318-399 AC A0A8C4T0J3.1
#=GS A0A315V7P9_GAMAF/322-403 AC A0A315V7P9.1
#=GS M3X212_FELCA/226-305 AC M3X212.4
#=GS A0A6P7LYW1_BETSP/296-377 AC A0A6P7LYW1.1
A0A670Y965_PSETE/133-198 ................etgrnvrv------.------------------.....--AP.RVTRGRTQELL.QEE-..---RLERTRLGggggg.ggssnSVA.LPRAER.........GAQ.ARAPNARPYRNK...................
A0A8C6PA17_NOTFU/289-371 ........................AATRGHmMKPLGLKEILGYLSSHER.....LSEE.KLTRGKVKVVM.EREV..ERGRLRRTRCG...........NIT.VPLRGMvl.....eeTVS.KNASSSRLAKSA...................
A0A9J7ZLD9_CYPCA/289-363 .......................a-ATRGQ.-APPGLKEILGYLSTQRG.....MPGE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIT.PAARGM.........G--.AAKPSARLLKSA...................
A0A8C4PQ49_EQUAS/221-288 .................sralprr------.---------------QRR.....RPGPaRLTRGRVQGLL.EEEAaaARGRPERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A2Y9L902_ENHLU/241-320 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A8C6R799_NANGA/109-157 ......................pr------.------------------.....----.-----RVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRsP--PTARASRSKrg.................
A0A8J4U8E2_CLAMG/218-309 ......................hq--NQNHqHAPLGLREILGFLGTQAGg..ahMGAE.KLTRSRVKVVL.EREI..ERGRLRRTRLG...........HIAaVPARRGggggggggeAAK.ASEASARLP---ast................
A0A096M7W4_POEFO/287-368 ........................AATRGH.VKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ERGRLRRTRCG...........NIT.LPLRGMep.....dePEP.SDSSADRLARSA...................
A0A811Z9X8_NYCPR/246-325 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
W5MUY9_LEPOC/295-369 .......................c-ASRGH.-TSLGLKEILGFLSSHER.....LSEE.KLTRSKVKVVL.EREV..ARGRLRRTRFG...........NIT.LPVRGA.........G--.-VKSTARLAKSAl..................
A0A6P9B4W8_PANGU/154-239 .....................pav---QEE.SSPVSLREIVRYLGGDGA.....APGGgRVTRGRAQGLL.QEE-..---RLERTRLGgggggggsssnSVA.LPRAER.........GAQ.ARAPNARPYRNK...................
A0A674JHB9_TERCA/163-242 ...................eeape-----R.SSPVSLREIVRYLGGDGS.....VAGGgRVTRGRVQGLL.EEEV..ARGRLERTRFG...........SIA.LARAER.........GPQ.GRAPHARAHRSKk..................
F7CUZ4_MONDO/152-233 .......................g-ASRSGpARPVSLREVVRYLGGS-G.....GGGG.RLTRGRVQGLLlEEEAaaARGRLERTRIA...........SLA.LPRNDR.........SGRaPPATSSRAARTK...................
A0A2U9BQW2_SCOMX/204-284 .......................a-PTRGH.MKPLGLKEILGYLSSQEQ.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGAaaa...aegPMP.KNASAG------rlp................
A0A8J6DVF5_GALPY/238-317 ......................aa--RTGGpARPVSLREVVRYLGGS-G.....GTGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASSRASRSK...................
A0A6J3GVQ3_SAPAP/126-205 .....................aar---AGGaARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARPSRSK...................
A0A3Q3M1U2_9TELE/301-382 ........................AATRGH.MKPLEMKEILGYLSSQER.....LSEE.KLTRGKVKEVM.EREV..ARGRLRRTRCG...........NIT.LPLRRMvv.....eqPMP.KNASADRLVKSA...................
A0A484DLU4_PERFV/199-280 .......................t-ATRGH.VKPLGLKEILGYLSSQDR.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRSRCG...........NIT.LPLRGVvv.....ekPMP.NKASADSLVKS-a..................
A0A2K5F0P0_AOTNA/128-207 .....................gar--RRAAaARARELREVVRYSGAA--.....AAPG.RLTRGRVQGLL.EEEA.gGAGRLERTRLG...........ALA.LPAGTG.........P--.------------dgrrgrqrpflrckr....
A0A8D2JSU4_SCIVU/132-211 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPSASARASRSK...................
A0A3Q1N125_BOVIN/236-315 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRvPPAASARASRSK...................
A0A8C0K0X2_CANLU/237-316 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A674A928_SALTR/395-478 .......................g-ETRGG.HKPLGLKEILGYLTSQDG.....LSSEgKLTRNRVKVVL.EREV..ARGRLRRTRCG...........NIT.LPVRGVea....apaPAK.------------ppgpantllkss.......
A0A2I4CN88_AUSLI/262-341 .......................p-AARGHxMKPLGLKEILGFLSSQER.....LSEE.KLTRGKVRVVM.EREV..ERGRLRRTRHG...........NIT.VLEEPR.........A--.--PSADRP----vrppqgrqe..........
A0A1A6H8K3_NEOLE/67-145 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA..ARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARAARSK...................
A0A6F9C7I0_9TELE/337-420 .......................g-ETRGG.HKPLGLKEILGYLTNQDG.....LSSEgKLTRNRVKVVL.EREV..ARGRLRRTRCG...........NIT.LPVRGVea....apvPAK.PHGPANRLLKSA...................
A0A2R8M4H5_CALJA/132-211 .....................aar---AGGaARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASSRPSRSK...................
SAMD1_HUMAN/239-318 ...................avrag----GA.ARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARPSRSK...................
A0A8C4WKV9_9SAUR/130-212 .................aapraep-----A.ASPVSLREIVRYLGGDGS.....AAGGgRVTRGRVQGLL.EEEV..ARGRLERTRFG...........SIA.LTRAER.........GPQ.GRAPHARAHRSKka.................
A0A2K5S740_CEBIM/90-169 .....................aar---AGGaARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARPSRSK...................
A0A8T3CVS5_9TELE/301-375 .......................a-AARGH.-TPLGLKEILGFLSSQER.....LSQE.KLTRSKVKVVL.EREV..ARGRLRRTRFG...........NIT.LPARGV.........G--.AAKPSARLLKSA...................
A0A8T0AD49_SILME/252-341 ....................sern----GRaHAPLGLKEILGFLGTQAAh...aTNGE.KLTRHRVKVVL.EREI..EKGRLRRTRLG...........HIA.VPARRSgg.....saG--.------------gsagastgadqaserlpvs
A0A7J7TAJ1_PIPKU/239-318 ...................aaras-----GpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRAQGLL.EEEA.aARGRLERTRLG...........ALA.PPRGDR.........PGRaPTAASARASRSK...................
A0A8C8Y7W2_PANLE/126-205 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A4X2M625_VOMUR/121-202 .......................g-ASRSGpARPVSLREVVRYLGGS-G.....SGGG.RLTRGRVQGLLlEEEAaaARGRLERTRIA...........GLA.LPRNDR.........SGRaPPATSSRAARTK...................
M4AD05_XIPMA/280-361 ........................AATRGH.VKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ERGRLRRTRCG...........NIT.LPLRGMep.....dePDP.SDSSADRLARSA...................
A0A498NVL1_LABRO/291-365 .......................a-ATRGH.-APPGLKEILGYLSTQRG.....MPGE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIT.LPARGM.........G--.AAKPSARLLKSA...................
A0A3P8SEG9_AMPPE/120-199 ......................pe--TEAD.CAPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGTv.......vEER.KNASADRLARSA...................
A0A556TL74_BAGYA/245-321 .......................r-NSRGH.-APLGLKEILGYLGTQAA.....HADGeKLTRHRVKVVL.EREI..EKGRLRRTRLG...........HIT.VSGRRW.........GK-.TDKASERL----pdnt...............
A0A8T2NHX4_9TELE/348-422 .......................a-AARGH.-TPLGLKEILGFLSSQER.....LSQE.KLTRSKVKVVL.EREV..ARGRLRRTRFG...........NIT.LPARGV.........G--.AAKPSARLLKSA...................
A0A2K6AV38_MACNE/90-169 ....................aara----GRrSRPVSLAEVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARQSRSK...................
A0A6P6KB20_CARAU/287-361 .......................a-ATRGH.-APPGLKEILDFLSTQRG.....MPEE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIT.LPARGM.........G--.AAKPSARLPRSA...................
A0A6G0JB93_LARCR/320-401 ........................AATRGH.MKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGMvv.....eePMP.KNASADRLGKNA...................
A0A671EPA5_RHIFE/132-211 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GASG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPASSARASRSK...................
A0A9B0X063_CHRAS/78-157 qqravlrvsykgsisyrnaarvqp------.-----------------G.....GAGG.RLTRGRVQGLL.EEEA..ARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAAGARASRSK...................
A0A6J2MF47_9CHIR/241-316 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQ---.EEAA..ARVRLERTRLG...........APA.LSRGER.........PGRaPPAASARASRSK...................
A0A8C5BRK9_GADMO/288-366 .......................g-ATRGQ.IKPLGLREILGHLSGQEW.....LSEE.KLTRGRVKGVL.EREI..ARGRLRRTRCG...........NIT.LPLRGV.........MVL.ENMTTDRHL---nrva...............
A0A2K5U8C5_MACFA/120-199 .....................aar---AGGaARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARQSRSK...................
A0A4D9DJZ8_9SAUR/160-240 ...................eeape-----R.SSPVSLREIVRYLGGDGS.....AAGGgRVTRGRVQGLL.EEEV..ARGRLERTRFG...........SIA.LARAER.........GAQ.GRGPHARAHRSKka.................
A0A8T3CME6_9TELE/290-371 .....................atf---KG-.HAPLGLKEILSFLSSQER.....LSQE.KLTRNKVKVVL.EREV..ARGRLRRTRFG...........NIT.LPVRGV.........VGK.---STARLLQS-alqdrqtak..........
F6T1W0_HORSE/241-320 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRPERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A7J8BV69_ROUAE/237-316 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARSRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A671X8K1_SPAAU/305-386 ........................AATRGH.MKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGMvv.....eePPP.KNASADRLVKSA...................
A0A6J1YLN1_ACIJB/102-177 ..............prrgatppap------.-------PVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A8M2BB29_DANRE/284-358 .......................a-ATRGH.-APPGLKEILDYLCTQKG.....MPGE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIT.LPARGM.........G--.AAKPSARLLKSA...................
A0A3N0Z147_ANAGA/274-348 .......................a-ATRGH.-APPGLKEILGYLSTQSG.....MPGE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIT.LHARGM.........G--.AAKQSARLLKSA...................
A0A3Q3FT00_9LABR/305-384 .......................t-ATRGH.GKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGMv.......lEEP.KNASADRLVKSA...................
A0A6I8N4R7_ORNAN/196-280 .......................g-AQRGGaVRPVSLREVVRYLGGSGGggagsGGGG.RVTRGRVQGLL.EEEA.vARGRPERTRLG...........GQA.LSRGER.........PGR.APAANPRAARSK...................
A0A9W2WIH6_PHYMC/130-209 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPSAASARASRSK...................
E9PIW9_HUMAN/133-212 ...................avrag----GA.ARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARPSRSK...................
A0A9D3S998_9TELE/248-330 .......................r-NSRGH.-APLGLKEILGYLGTQAA.....HADGeKLTRHRVKVVL.EREI..EKGRLRRTRLG...........HIT.VPGRRWgg....stgAAK.ASEASARL----pant...............
A0A8J7T8S5_ATRSP/284-359 .......................c-ASRGH.-TSLGLKEILGFLSSHER.....LSEE.KLTRSKVKVVL.EREV..ARGRLRRTRFG...........NIT.LPVRGV.........G--.-VKSTARLAKSAlq.................
A0A452EQ70_CAPHI/236-315 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRK-e..................
A0A8C4M6M3_EQUAS/123-195 .....................aaa--RAGGpARPVSLREVVRYLGGS--.....----.----GGGRGLL.EEEAaaARGRPERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A7J7RA88_MYOMY/239-318 ...................aaras-----GpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRAQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPTAASARASRSK...................
A0A2U4AZD4_TURTR/242-321 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPSAASARASRSK...................
W5P992_SHEEP/129-171 .....................plp------.------------------.....----.-----------.EEAA..ARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A8D2DZX8_SCIVU/238-317 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPSASARASRSK...................
A0A6P6N2D6_CARAU/285-359 .......................a-ATRGH.-APPGLKEILDYLSTQRG.....MPGE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIT.AAARGM.........G--.AAKPSSRLLKSA...................
A0A287A2N4_PIG/227-306 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........APV.VPRGDR.........PGRaPPAASARASRSK...................
A0A3Q3B7Z5_KRYMA/290-372 .......................a-AARGHmMKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGMvl.....eeTAP.KPPAADRLEKSA...................
A0A5E4AA29_MARMO/233-312 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPSASSRASRSK...................
A0A669D207_ORENI/303-384 .......................a-VTRGH.MKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGVvv.....eePMP.KNASADRLAKSA...................
G3Q4V1_GASAC/228-307 .......................t-ATGGH.AKPLGLKEILGHLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIA.LPLRGA.........AAE.EP----------srappppspred.......
A0A8C0AJX2_BOSMU/232-311 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRvPPAASARASRSK...................
A0A8M1M7G6_NEOSC/109-188 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A7J6DGL0_9TELE/291-365 .......................a-ATRGH.-APPGLKEILGYLSTQRG.....VPGE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIT.LAARGM.........G--.AAKPSARLLKSA...................
H2NXS6_PONAB/228-307 .....................aar---AGGaARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARPSRSK...................
A0A060ZEW0_ONCMY/175-258 .......................g-ETRGG.HKPLGLKEILGYLTSQDG.....LSSEgKLTRNRVKVVL.EREV..ARGRLRRTRCG...........NIT.LPVRGVea....aptPAK.PPGPANRLLKSA...................
A0A9D3LQF9_ANGAN/289-371 .....................aal---KGH.-APLSLKEILGFLSSQER.....LSQE.KLTRSKVKVVL.EREV..ARGRLRRTRFG...........NIT.LPVRGV.........VGK.---SHARLLQS-avqdrqtakk.........
H0Y1N4_OTOGA/1-52 .......................x------.------------------.....----.-LTRGRVQGLL.EEEA.aARGRLERTRLG...........ALT.LPRGDR.........PGRaPTTASARPSRSK...................
SAMD1_RABIT/248-327 ......................aa--RAGGpARPVSLREVVRYLGGS-S.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARAARNK...................
A0A8M1FRU4_URSMA/233-312 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A8U0TQ90_SALNM/340-421 .......................g-ETRGG.HKPLGLKEILGYLTSQDG.....LSSEgKLTRNRVKVVL.EREV..ARGRLRRTRCG...........NIT.LPVRGVe......aaPAK.PTGPANRLLKSA...................
A0A4W5MQL0_9TELE/153-236 .......................g-ETRGG.HKPLGLKEILGYLTSQDG.....LSSEgKLTRNRVKVAL.EREV..ARGRLRRTRCG...........NIT.LPVRGVea....apaPSK.PPGPANRLLKS-e..................
A0A452ER51_CAPHI/231-310 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A4Z2E2Z0_9TELE/305-388 ........................AATRGH.IKPLGLKEILGYLSSHDR.....LSEQ.QLTRGKVKVVM.EREV..ARGRLRRTRSG...........NIT.LPLRGSaee...keeEER.KNAPADRLAKSA...................
A0A4U5U4A1_COLLU/313-394 .......................a-AARGH.MKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGMvv.....eePTP.KNASADRLGKNA...................
A0A8P4FWK3_DICLA/307-388 ........................AATRGH.TKSLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGVvv.....eePMP.KNASADRLIKSA...................
A0A5F8ACB3_MACMU/238-317 .....................aar---AGGaARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARQSRSK...................
A0A3Q1LS12_BOVIN/133-212 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRvPPAASARASRSK...................
A0A6P8W7R1_GYMAC/294-371 .......................s-ATRGH.MQPLGLKEIVGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGV.........VTE.DPRTADRLVKSA...................
A0A3Q1EVK3_9TELE/299-378 ........................AATRGH.MKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGMa.......vEEP.KNASADRLARSA...................
A0A8C1FDY2_CYPCA/261-335 .......................a-ATRGH.-APPGLKEILDFLSTQRG.....MPEE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIA.LPARGM.........G--.AAKPSARLLKSA...................
A0A8C2WZR6_CYCLU/303-385 ........................AATRGH.MKPLGLKEILGYLSSQDR.....LSEQ.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGVva....aeePMP.KNASADRLAKSA...................
A0A6J1UVZ4_9SAUR/165-230 ................etgrnvrv------.------------------.....--AP.RVTRGRTQELL.QEE-..---RLERTRLGggggg.ggssnSVA.LPRAER.........GAQ.ARAPNARPYRNK...................
A0A8C3W3U1_9CETA/238-317 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........APV.VPRGDR.........PGRaPPAASARASRSK...................
A0A1S3L486_SALSA/394-477 .......................g-ETRGG.HKPLGLKEILGYLTSQDG.....LSSEgKLTRNRVKVVL.EREV..ARGRLRRTRCG...........NIT.LPVRGVea....apaPAK.PPGPANRLLKS-s..................
A0A669EWY4_ORENI/303-384 .......................a-VTRGH.MKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGVvv.....eePMP.KNASADRLAKSA...................
A0A8D2J211_VARKO/130-211 .....................paq----EE.SSPVSLREIVRYLGGDGA.....APGGgRVTRGRAQGLL.QEE-..---RLEKTRLGgggg...gggnSVA.LPRAER.........GAQ.ARAPNARAYRNK...................
A0A8C7N018_ONCKI/411-494 .......................g-ETRGG.HKPLGLKEILGYLTSQDG.....LSSEgKLTRNRVKVVL.EREV..ARGRLRRTRCG...........NII.LPVRGVea....astPAK.PPGPANRLLKSA...................
A0A8C7EMF5_NEOVI/150-209 ...................xxxxx------.------------------.....-XGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A1S3QLF4_SALSA/335-418 .......................g-ETRGG.HKPLGLKEILAYLTSQDG.....LSSEgKLTRNRVKVVL.EREV..ARGRLRRTRCG...........NIT.LPVRGVea....apaPAK.------------ppgpantllkss.......
A0A9D4AZV5_9SAUR/163-242 ...................eeape-----R.SSPVSLREIVRYLGGDGS.....AAGGgRVTRGRVQGLL.EEEV..ARGRLERTRFG...........SIA.LARAER.........GPQ.GRAPHARAHRSKk..................
A0A8C9IQH9_9PRIM/137-212 ..................xxxxxx------.---XSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRFG...........ALA.LPRGDR.........PGRaPPAASARQSRSK...................
A0A553QBQ2_9TELE/215-292 ......................gg--HRRH.APPPGLKEILELLSTQSA.....TPDE.KLTRHRVNREL.EREI..ARGRLRRTRLG...........HIT.VPGRAR.........PER.----APRDGRS-aetdk..............
A0A4W2F2E6_BOBOX/364-443 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRvPPAASARASRSK...................
A0A5E4A9T5_MARMO/233-312 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPSASSRASRSK...................
H3AP11_LATCH/204-289 ......................sl--RRGQePKAVTLKELMRVLSSELG.....LPKE.KVTKSKVKGAL.EKEV..AKGRLKRSRFG...........NIT.LPGEGGqsk...gnrRNK.------------aptftplragrgk......
A0A9J8B2B9_CYPCA/289-363 .......................a-ATRGH.-APPGLKEILDFLSTQRG.....MPEE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIA.LPARGM.........G--.AAKPSARLLKSA...................
A0A8D2EM84_THEGE/132-211 .....................aar---AGGaARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARQSRSK...................
A0A8D0BBD8_SALMN/124-206 .....................paq--EESS.SSPVSLRDTERYWGGDGA.....APAGgRVTRGRAQGLL.QQE-..--ERLERTRLGggg.....ggnSVA.LPRAER.........GAQ.ARAPNARPYRNK...................
A0A6J2PM59_COTGO/301-383 .......................t-TTRGH.MKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGMvv....veePTP.KNASADRLVKSA...................
A0A2K5NZ79_CERAT/68-147 .....................aar---AGGaARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARQSRSK...................
A0A3Q2GFL3_CYPVA/252-327 ........................AATRGH.VKPLGLKEILGYLSSQEQ.....LSEE.KLTRGKVKAVM.EREV..ERGRLRRTRCG...........NIT.LPLRGM.........E--.-NPTADRLV---grsa...............
A0A6P5KZW9_PHACI/208-289 .......................g-ASRSGpARPVSLREVVRYLGGS-G.....SGGG.RLTRGRVQGLLlEEEAaaARGRLERTRIT...........GLA.LPRNDR.........SGRaPPATSSRAARTK...................
A0A3P9MT77_POERE/208-289 ........................AATRGH.VKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ERGMLRRTRCG...........NIT.LPLRGMep.....dePEP.SDSSADRLARSA...................
A0A498L779_LABRO/291-365 .......................a-ATRGH.-APPGLKEILGYLSTQRG.....MPGE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIT.LPARGM.........G--.AAKPSARLLKSA...................
A0A3P9A3N7_ESOLU/332-409 .......................g-ETRGG.HKPLGLKEILGYLASQDG.....MSSEgKLTRNRVKVVL.EKEV..ERGRLRRTRCG...........NIT.LPVRGV.........EA-.AAKPTDRLLKSA...................
A0A8C6D7N7_MOSMO/238-317 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A672L365_SINGR/280-354 .......................a-ATRGH.-APPGLKEILGYLSTQRG.....MPGE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIT.PAARGM.........G--.AAKPSARLLKSA...................
A0A8C9B1M1_PHOSS/240-319 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPSAASARASRSK...................
A0A7J6A0H2_AMEME/253-329 .......................r-NSRGH.-APLGLKEILGYLGTQAA.....HADGeKLTRHRVKVVL.EREI..EKGRLRRTRLG...........HIA.VPARRW.........G--.ATKASARLP---antd...............
A0A9D3T4F8_MEGAT/293-374 ...................apfgg------.RTSLGLKEILGFLSSQGR.....LTQE.KLTRSKVKVIL.EREV..ARGRLRRTRFG...........NIT.LPVRGVv......gkPL-.------------rplqsalqdrkitek....
A0A7N4V3D1_SARHA/210-291 .......................g-ASRSGpARPVSLREVVRYLGGS-G.....GGGG.RLTRGRVQGLLlEEEAaaARGRLERTRIA...........SLA.LPRNDR.........SGRaPPATSSRAARTK...................
A0A452INQ3_9SAUR/126-205 ...................eeape-----R.SSPVSLREIVRYLGGDGS.....AAGGgRVTRGRVQGLL.EEEV..ARGRLERTRFG...........SIA.LARAER.........GPQ.GRAPHARAHRSKk..................
A0A8C3WAW8_9CETA/132-211 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........APV.VPRGDR.........PGRaPPAASARASRSK...................
A0A8U0V5T0_MUSPF/242-321 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A3Q1I5A2_ANATE/292-375 ......................rn--LRGH.MKPLGLKEILSYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGMvv....veePTTpKNACADRLGKSA...................
A0A6A5FNL3_PERFL/305-386 .......................t-ATRGH.VKPLGLKEILGYLSSQDR.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRSRCG...........NIT.LPLRGMvv.....ekPMP.KKASADSLVKSA...................
A0A8D2HD61_UROPR/228-307 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPSASARASRSK...................
SAMD1_MOUSE/220-298 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GASG.RLTRGRVQGLL.EEEA..ARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARAARSK...................
A0A8C5D7U2_9TELE/219-298 .................snqggpt------.GKPLGLKEILGYLSSQER.....LSEE.KLTRGNVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGA.........E--.------------ldelrdssndgvaes....
A0A3Q2VP01_HAPBU/303-384 .......................t-VTRGH.MKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGVvv.....eePMP.KNASADRLAKSA...................
A0A4W6DKQ3_LATCA/306-387 ........................AATRGH.MKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGMvv.....eePTP.KNASAERLVKSA...................
A0A2K6JVH9_RHIBE/1-50 ........................------.------------------.....----.--TRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARQSRSK...................
A0A4U1EQE4_MONMO/122-201 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPSAASARASRSK...................
A0A7N9IA20_MACFA/194-273 .....................aar---AGGaARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARQSRSK...................
G3SUU8_LOXAF/1-72 ......................pa------.-RPVSLR-VVRYGGS--G.....GAGG.RLTRGRVQELL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A8C5VQV0_MICMU/140-203 ...................rpvsc------.---------------GSG.....GSGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARPSRSK...................
A0A2K6F7H4_PROCO/122-201 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GSGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPTASARPSRG-k..................
A0A6I9P658_9TELE/295-372 .......................s-ATRGH.MQPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGV.........VTE.EPRTADRLVKSA...................
A0A8C9XKT1_SANLU/304-385 .......................t-ATRGH.VKPLGLKEILGYLSSQDR.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRSRCG...........NIT.LPLRGMvv.....ekPMP.KKASADSLVKSA...................
A0A670K9R3_PODMU/164-247 ...................papee------.PSPVSLREIVRYLGGDGA.....APGGgRVTRGRAQGLL.QEE-..---RLERTRLGggggg.ggsgnSVA.LPRAER.........GAQ.ARAPSARAYRNK...................
A0A6I9XR28_9SAUR/154-239 ......................pa--AQEE.SSPVSLREIVRYLGGDGA.....APGGgRVTRGRAQGLL.QEE-..---RLERTRLGgggggggsssnSVA.LPRAER.........GAQ.ARAPNARPYRNK...................
A0A6P7IZU4_9TELE/303-384 ........................AATRGH.MKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRYG...........NIT.LPLRGMvv.....eePMS.KNASSDRLAKSA...................
A0A7J8IC98_MOLMO/239-318 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LSRGDR.........PGRaLPAASARASRSK...................
A0A9D3QIA3_MEGAT/339-413 .......................a-AARGH.-TPLGLKEILGFLSSQER.....LSQE.KLTRSKVKVVL.EREV..ARGRLRRTRFG...........NIT.LPVRGV.........G--.AAKPSARLLKSA...................
A0A340YB76_LIPVE/1-69 ........................------.----SLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPLAASVRASRSK...................
A0A7J5Y3W2_DISMA/346-423 .......................s-ATRGH.MQPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGV.........VTE.EPRTADRL----ppsp...............
A0A8B7TVA3_CASCN/242-321 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A8B8WZC6_BALMU/239-318 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPSAASARASRSK...................
A0A6P8F5G6_CLUHA/322-396 .......................t-ATRG-.PTPLGLKEILGYLSTQSG.....LGEE.KLTRSRVKAVL.EREV..ARGRLRRTHLG...........HIA.LPTRGM.........G--.AAKPSARLLKSA...................
A0A5J5N3A1_MUNRE/28-107 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A3Q7PS58_CALUR/101-179 ......................pp--RRGA.TPPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A8I6AKG2_RAT/220-298 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GASG.RLTRGRVQGLL.EEEA..ARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARAARSK...................
A0A6P8X4R3_GYMAC/294-371 .......................s-ATRGH.MQPLGLKEIVGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGV.........VTE.DPRTADRLVKSA...................
A0A671ETG5_RHIFE/234-313 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GASG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPASSARASRSK...................
A0A8X8BYT4_POLSE/321-400 .......................s-TARGHpPPQLGLKEILGFLSSQER.....LSQE.KLTRSKVKVVL.EREV..AKGRLRRTRFG...........NIT.LPVRGE.........ARS.-----ARHA---kttttatsp..........
A0A9D3S8S6_ANGAN/298-373 ......................aa-AARG-.PTPLGLKEILGFLSSQER.....LSQE.KLTRSKVKVVL.EREV..ARGRLRRTRFG...........NIT.LPVRGV.........G--.AAKPSARLLKSA...................
A0A553QBP8_9TELE/215-292 ......................gg--HRRH.APPPGLKEILELLSTQSA.....TPDE.KLTRHRVNREL.EREI..ARGRLRRTRLG...........HIT.VPGRAR.........PER.----APRDGRS-aetdk..............
A0A1S3QJH8_SALSA/335-418 .......................g-ETRGG.HKPLGLKEILAYLTSQDG.....LSSEgKLTRNRVKVVL.EREV..ARGRLRRTRCG...........NIT.LPVRGVea....apaPAK.------------ppgpantllkss.......
A0A3Q4G5R8_NEOBR/263-336 .............lgdrlvasvrs------.------------LSE-KS.....LRGG.SLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGVvv.....eePMP.KNASADRLAKSA...................
A0A1U7R7G0_MESAU/1-43 ........................------.------------------.....----.--------GLL.EEEA..ARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARAARSK...................
A0A0D9R232_CHLSB/1-68 ........................------.-----LREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARQSRSK...................
A0A8C6D2L9_MOSMO/131-210 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A5A9PJJ3_9TELE/167-241 .......................a-ATRGH.-APLGLKEILGYFSTQTG.....VPGE.KLTRNRVKVVL.EREI..EQGRLRRTRLG...........HIT.LLARGM.........G--.AAKPSARLLKSA...................
A0A8J6G2V8_MICOH/358-436 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GPSG.RLTRGRVQGLL.EEEA..ARSRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARAARSK...................
A0A0A0MWZ2_PAPAN/222-301 .....................aar---AGGaARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARQSRSK...................
A0A3Q1DD23_AMPOC/304-383 ........................AATRGH.MKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGTv.......vEER.KNASADRLARSA...................
A0A673AXW3_9TELE/307-389 .......................a-AARGH.MKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGMvv.....eePMPvKNASADRLEKSA...................
A0A3P8SEJ9_AMPPE/211-272 .....................srf------.---------------QER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGTv.......vEER.KNASADRLARSA...................
A0A0N8JUW3_SCLFO/52-119 ................iqeqtvlr------.----------------ER.....LAQE.KLTRSRVKVVL.EREV..ARGRLRRTRFG...........NIT.LPVSARpr.....piA-PgAPKSSARALKSA...................
A0A5N5JWU3_PANHP/263-342 .......................r-NSRGH.-APLGLKEILGYLGTQAA.....HADGeKLTRHRVKVVL.EREI..EKGRLRRTRLG...........HIT.VPARRW........gGSTgAAKASARLP---ant................
A0A672QNJ0_SINGR/287-361 .......................a-ATRSH.-APPGPKEILGFLSTQRG.....MPGE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIT.LPARGM.........G--.AAKPSARLLKSA...................
A0A8I3PXF9_CANLF/237-316 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A6G1PAQ7_9TELE/302-383 .......................t-ATRGH.IKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGVvv.....eePKP.KNASTDRLVKSA...................
A0A7N4PVQ5_SARHA/210-291 .......................g-ASRSGpARPVSLREVVRYLGGS-G.....GGGG.RLTRGRVQGLLlEEEAaaARGRLERTRIA...........SLA.LPRNDR.........SGRaPPATSSRAARTK...................
H2R2Z5_PANTR/104-184 ...................avrag----GA.ARPVSLREVVRYLGGSGG.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARPSRSK...................
A0A665WAH0_ECHNA/308-387 .......................t-ATRGH.MKPLELKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..ARGRLRRTRCG...........NIT.LPLRGMa.......vEEP.KNASADRLAKSA...................
A0A6J2VWL1_CHACN/304-378 .......................s-ATRGH.-TALGLKEILGYLSTQGG.....MPEE.KLTRNRVKVVL.EREV..AKGRLRRTRLG...........HIT.LPTRGM.........G--.LAKPSARLLKSA...................
A0A6P6PC04_CARAU/286-360 .......................a-ATRGH.-APPGLKEILDYLSTQRG.....MPGE.KLTRNRVKVVL.EREI..ERGRLRRTRLG...........HIT.AAARGM.........G--.AAKPSARLLKSA...................
A0A2Y9LXH6_DELLE/33-112 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPSAASARASRSK...................
A0A8C4G4L7_9TELE/201-285 ......................ag--SRGSgPAPLGLREVLAHLSAHGG.....PAEE.TLTRGRVRAVL.EREV..ARGRLRRTRFG...........HIA.LAAAER.........RRS.PAAE--------vtsherrgaarrvr.....
A0A4W4H929_ELEEL/303-377 ......................va--IRGH.-ALLGLKEILGYLSTQAG.....QTEE.KLTRNRVKVVL.EREI..EKGRLRRTRLG...........HIT.VPARGM.........G--.AAKPSARLLKSA...................
A0A8C4T0J3_ERPCA/318-399 .......................s-TARGH.PPPLGLKEILGFLSSQER.....LSQE.KLTRSKVKVVL.EREV..AKGRLRRTRFG...........NIT.LPVRGE.........ARS.-----ARHA---kttatspphqer.......
A0A315V7P9_GAMAF/322-403 ........................AATRGH.VKPLGLKEILGYLSSQER.....LSEE.KLTRGKVKVVM.EREV..EKGRLRRTRCG...........NIT.LPLRGMep.....dePEP.SDSSADRLAKSA...................
M3X212_FELCA/226-305 ......................aa--RAGGpARPVSLREVVRYLGGS-G.....GAGG.RLTRGRVQGLL.EEEA.aARGRLERTRLG...........ALA.LPRGDR.........PGRaPPAASARASRSK...................
A0A6P7LYW1_BETSP/296-377 .......................a-ASRGH.MKPLGLKEILGYLSSQER.....LSDE.TLTRGKVKVVM.EREV..AKGRLRRTRCG...........NIT.LPLRGMvv.....eePVP.KDASADRLVRSA...................
#=GC seq_cons .......................s..ptGt.h+PluL+ElltYLuup.u.....huut.+LTRGRVpslL.EcEs..ARGRLcRTRlG...........sls.LPttst.........Psp.ssAuoARhs+St...................
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