GenomeNet

Database: Pfam
Entry: SAM_Exu
LinkDB: SAM_Exu
Original site: SAM_Exu 
#=GF ID   SAM_Exu
#=GF AC   PF18609.3
#=GF DE   Exuperantia SAM-like domain
#=GF PI   Exu_SAM;
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF07930
#=GF GA   28.90 28.90;
#=GF TC   32.60 29.80;
#=GF NC   26.30 25.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0003
#=GF RN   [1]
#=GF RM   27376588
#=GF RT   The bicoid mRNA localization factor Exuperantia is an
#=GF RT   RNA-binding pseudonuclease.
#=GF RA   Lazzaretti D, Veith K, Kramer K, Basquin C, Urlaub H, Irion U,
#=GF RA   Bono F;
#=GF RL   Nat Struct Mol Biol. 2016;23:705-713.
#=GF DR   INTERPRO; IPR040941;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Exuperantia (Exu) is associated with localization of bicoid
#=GF CC   (bcd) mRNA and required for its localization at the anterior
#=GF CC   pole of the oocyte. Crystal structure of Exu reveals a dimeric
#=GF CC   assembly with each monomer consisting of a 3'-5' EXO-like domain
#=GF CC   and a sterile alpha motif (SAM)-like domain. The SAM-like domain
#=GF CC   interacts with its target RNA as a homodimer and is required for
#=GF CC   RNA binding activity [1].
#=GF SQ   106
#=GS A0A182G7T8_AEDAL/392-463  AC A0A182G7T8.1
#=GS W5J7G2_ANODA/360-431      AC W5J7G2.1
#=GS A0A2P8Z427_BLAGE/263-335  AC A0A2P8Z427.1
#=GS B4GGY8_DROPE/299-370      AC B4GGY8.1
#=GS A0A6A4K426_APOLU/327-397  AC A0A6A4K426.1
#=GS EXU1_DROPS/299-370        AC Q24618.2
#=GS B4QF43_DROSI/325-396      AC B4QF43.1
#=GS A0A151I2L3_9HYME/266-338  AC A0A151I2L3.1
#=GS B4MQI9_DROWI/322-393      AC B4MQI9.1
#=GS A0A0N1IHY0_PAPMA/272-344  AC A0A0N1IHY0.1
#=GS A0A6G0Z5T7_APHCR/271-338  AC A0A6G0Z5T7.1
#=GS E9GKX8_DAPPU/213-285      AC E9GKX8.1
#=GS A0A151WZW0_9HYME/265-337  AC A0A151WZW0.1
#=GS A0A3B0IZT9_DROGU/300-371  AC A0A3B0IZT9.1
#=GS EXU_DROME/325-396         AC P28750.2
#=GS EXU_DROME/325-396         DR PDB; 5L80 B; 275-343;
#=GS EXU_DROME/325-396         DR PDB; 5L80 A; 272-343;
#=GS E9HLH8_DAPPU/313-385      AC E9HLH8.1
#=GS A0A0J7KKA6_LASNI/76-148   AC A0A0J7KKA6.1
#=GS A0A0L7QRE5_9HYME/268-340  AC A0A0L7QRE5.1
#=GS A0A0L7KXY6_9NEOP/111-175  AC A0A0L7KXY6.1
#=GS E0VAW5_PEDHC/259-333      AC E0VAW5.1
#=GS A0A2J7QQD4_9NEOP/81-153   AC A0A2J7QQD4.1
#=GS A0A087ZTV1_APIME/267-339  AC A0A087ZTV1.1
#=GS E9HXI3_DAPPU/51-111       AC E9HXI3.1
#=GS E9HU85_DAPPU/263-335      AC E9HU85.1
#=GS B4HQN5_DROSE/325-396      AC B4HQN5.1
#=GS A0A653CZM7_CALMS/271-343  AC A0A653CZM7.1
#=GS A0A026X1U4_OOCBI/271-343  AC A0A026X1U4.1
#=GS E9GSP2_DAPPU/199-264      AC E9GSP2.1
#=GS EXU_DROVI/300-371         AC Q24747.1
#=GS E9HAV7_DAPPU/579-651      AC E9HAV7.1
#=GS B0WUE0_CULQU/304-374      AC B0WUE0.1
#=GS A0A484AVC6_DRONA/252-322  AC A0A484AVC6.1
#=GS A0A2W1B9I5_HELAM/271-321  AC A0A2W1B9I5.1
#=GS B4K0P3_DROGR/295-366      AC B4K0P3.1
#=GS A0A5E4PPM0_9NEOP/251-323  AC A0A5E4PPM0.1
#=GS E2AQD8_CAMFO/266-338      AC E2AQD8.1
#=GS A0A0T6B4S9_9SCAR/265-337  AC A0A0T6B4S9.1
#=GS J9JXF7_ACYPI/271-341      AC J9JXF7.1
#=GS E9HMJ0_DAPPU/276-348      AC E9HMJ0.1
#=GS E9HYX0_DAPPU/261-303      AC E9HYX0.1
#=GS Q16TW3_AEDAE/385-456      AC Q16TW3.1
#=GS E9HTE1_DAPPU/189-261      AC E9HTE1.1
#=GS EXU2_DROPS/306-377        AC Q24617.1
#=GS B4M2F2_DROVI/260-330      AC B4M2F2.2
#=GS A0A195F464_9HYME/266-338  AC A0A195F464.1
#=GS A0A0Q9X7F8_DROMO/308-379  AC A0A0Q9X7F8.1
#=GS E9GUY9_DAPPU/268-343      AC E9GUY9.1
#=GS A0A1J1ITK6_9DIPT/249-320  AC A0A1J1ITK6.1
#=GS A0A1J1I8J0_9DIPT/53-116   AC A0A1J1I8J0.1
#=GS B4GYD4_DROPE/268-339      AC B4GYD4.1
#=GS A0A6A4KJT8_APOLU/309-379  AC A0A6A4KJT8.1
#=GS A0A4S2JTY0_9HYME/273-345  AC A0A4S2JTY0.1
#=GS A0A195E3K0_9HYME/266-338  AC A0A195E3K0.1
#=GS A0A6I8VHI8_DROPS/306-377  AC A0A6I8VHI8.1
#=GS B4GYD7_DROPE/137-208      AC B4GYD7.1
#=GS A0A1S4E8I1_DIACI/269-343  AC A0A1S4E8I1.1
#=GS A0A2A4JK56_HELVI/271-343  AC A0A2A4JK56.1
#=GS A0A182XYN5_ANOST/195-261  AC A0A182XYN5.1
#=GS A0A553NNW8_TIGCA/278-349  AC A0A553NNW8.1
#=GS H9JWT2_BOMMO/244-316      AC H9JWT2.1
#=GS E9HX57_DAPPU/158-230      AC E9HX57.1
#=GS W5JWG6_ANODA/360-431      AC W5JWG6.1
#=GS A0A2J7QQC9_9NEOP/263-335  AC A0A2J7QQC9.1
#=GS A0A1W4WW29_AGRPL/267-339  AC A0A1W4WW29.1
#=GS B4J965_DROGR/295-366      AC B4J965.1
#=GS A0A5E4MZM6_9HEMI/274-341  AC A0A5E4MZM6.1
#=GS A0A194PWP5_PAPXU/289-361  AC A0A194PWP5.1
#=GS Q7PT28_ANOGA/368-439      AC Q7PT28.4
#=GS T1GIA2_MEGSC/259-330      AC T1GIA2.1
#=GS B4LA16_DROMO/257-327      AC B4LA16.2
#=GS A0A3B0JKP7_DROGU/236-307  AC A0A3B0JKP7.1
#=GS A0A653D1B1_CALMS/193-265  AC A0A653D1B1.1
#=GS E9HHX2_DAPPU/225-290      AC E9HHX2.1
#=GS E9G1V1_DAPPU/77-149       AC E9G1V1.1
#=GS E9G1V0_DAPPU/197-269      AC E9G1V0.1
#=GS A0A067R7W9_ZOONE/268-340  AC A0A067R7W9.1
#=GS E9GNG4_DAPPU/1-58         AC E9GNG4.1
#=GS A0A3B0JE28_DROGU/47-114   AC A0A3B0JE28.1
#=GS A0A182XYN5_ANOST/791-862  AC A0A182XYN5.1
#=GS A0A6I8WAF1_DROPS/306-377  AC A0A6I8WAF1.1
#=GS B3MIT1_DROAN/310-381      AC B3MIT1.1
#=GS A0A6G0T2Q6_APHGL/581-647  AC A0A6G0T2Q6.1
#=GS A0A195D162_9HYME/266-338  AC A0A195D162.1
#=GS T1HBK3_RHOPR/234-304      AC T1HBK3.1
#=GS A0A154PRH3_DUFNO/267-339  AC A0A154PRH3.1
#=GS A0A158P1F4_ATTCE/266-338  AC A0A158P1F4.1
#=GS A0A2A3EEB3_APICC/267-339  AC A0A2A3EEB3.1
#=GS N6TK10_DENPD/268-340      AC N6TK10.1
#=GS A0A0Q9W9P7_DROVI/300-371  AC A0A0Q9W9P7.1
#=GS A0A1Y1LZ98_PHOPY/264-336  AC A0A1Y1LZ98.1
#=GS F4WYK4_ACREC/266-338      AC F4WYK4.1
#=GS D6WRU5_TRICA/268-340      AC D6WRU5.1
#=GS A0A484BPW4_DRONA/308-379  AC A0A484BPW4.1
#=GS A0A164T201_9CRUS/386-458  AC A0A164T201.1
#=GS A0A0M8ZV13_9HYME/267-339  AC A0A0M8ZV13.1
#=GS A0A212FEN1_DANPL/117-189  AC A0A212FEN1.1
#=GS E2C9Q4_HARSA/271-343      AC E2C9Q4.1
#=GS A0A4C1VU95_EUMVA/268-340  AC A0A4C1VU95.1
#=GS A0A3S2NIW9_CHISP/272-344  AC A0A3S2NIW9.1
#=GS A0A310SQF0_9HYME/267-339  AC A0A310SQF0.1
#=GS B4KR35_DROMO/345-416      AC B4KR35.2
#=GS E9I2X2_DAPPU/1-50         AC E9I2X2.1
#=GS E9GJP8_DAPPU/34-99        AC E9GJP8.1
#=GS E1JGN9_DROME/325-396      AC E1JGN9.1
#=GS A0A6I8WA49_DROPS/255-326  AC A0A6I8WA49.1
#=GS A0A1D2N4U7_ORCCI/250-323  AC A0A1D2N4U7.1
A0A182G7T8_AEDAL/392-463             .....RPVFLQYFKT.TIY.HRVKAVTYRRVLAEYGHDFASLQQIWNDS...K..REGLEVVV-SKIS.ELK.EEERTELVELLDCH............
W5J7G2_ANODA/360-431                 .....RPVFLLYFKT.TIY.HRVKAVTYRRVLAEIGHDYESLRKVWQES...K..REGMEAIV-NKII.ELK.EEERTELTELLDCH............
A0A2P8Z427_BLAGE/263-335             .....RPIFGALLGI.NKQ.ERQRAVNLRRILVEAGIDYAMLKAAYGKD...G..KESIAELLSSKVP.NTK.QKEADELKELLIHH............
B4GGY8_DROPE/299-370                 .....RPVFLNYFRT.TLY.HRVRAVKFRIVLAENGFTLDSLKAIWTEK...R..KEGLELAL-TNID.TLK.TEEKTELVELLDSF............
A0A6A4K426_APOLU/327-397             .....KPIFEHLIKI.SS-.ERKRAIVLRQYLTDANIDFQSLNLVVKEE...K..D--MKQYLHSKIGgELP.EKDLSDLETVVTKH............
EXU1_DROPS/299-370                   .....RPVFLNYFRT.TLY.HRVRAVKFRIVLAENGFTLDSLKAIWTEK...R..KEGLELAL-TNID.TLK.TEEKTELVELLDSF............
B4QF43_DROSI/325-396                 .....RPVFLNYFKT.TLY.HRVRAVKFRIVLAENGFDLNKLSAIWAEK...Q..TEGLDMAL-QSIG.RLK.IKDKTELLELLDSY............
A0A151I2L3_9HYME/266-338             .....RPIFSALFRM.NRR.ERQHASPLRRLLAEAGIVYSELQDAWTNA...K..KDGLEHLMKEKLP.TVE.EKKMEDLMIILERH............
B4MQI9_DROWI/322-393                 .....RPVFLNYFKT.TLY.HRVRAVKFRIVLAENGFDLSSLKTIWTEN...S..SAGVDKAL-QSIT.SLK.PEDKSELVELLDSY............
A0A0N1IHY0_PAPMA/272-344             .....RPVFAPLLRA.ARP.ERKRVTQLRRILAEAGFLYDQLRDAWQEH...K..LTGLEKQLASLSV.SAK.EEDIKELIEIFDCH............
A0A6G0Z5T7_APHCR/271-338             slsyq---------T.SAL.DRKKAISYRNSIAKANIDYMTLQSLWTEN...-..KDGFKDAVKEKLP.ELS.DDDKENIVT-----tiimh.......
E9GKX8_DAPPU/213-285                 .....RPVFADMFRQ.GIK.PRWRAGFLRHMPVESGITYAGLTETFKDK...K..DDGVVEVIKENIK.GKN.EADVEEVIKLLNQH............
A0A151WZW0_9HYME/265-337             .....RPIFSALFRM.NRR.ERQHASPLRRLLAEAGIVYSELQDAWTNA...K..KDGLEHLMKEKLP.TVD.EKKMEDLMIILERH............
A0A3B0IZT9_DROGU/300-371             .....RPLFLNYFRN.TLY.HRVRAVKFRIVLAENGFTLDSLNDIWTEK...G..KEGLDLAL-AAID.TLK.DEEKTELLDLLDSF............
EXU_DROME/325-396                    .....RPVFLNYFKT.TLY.HRVRAVKFRIVLAENGFDLNTLSAIWAEK...N..IEGLDIAL-QSIG.RLK.SKDKAELLELLDSY............
#=GR EXU_DROME/325-396         SS    .....TTTTHCHHHH.-HH.HHHHHHHHHHHHHHTT--HHHHHHHHH--...-..--THHHHH-HT-T.T--.HHHHHHHHHHHHTT............
E9HLH8_DAPPU/313-385                 .....RPVFADMFRQ.GIK.PRRRAGFLRHMLVESGITYVGLTETFKDK...K..DDGVVEVIKENIK.GKN.EADVEEVIKLLNQH............
A0A0J7KKA6_LASNI/76-148              .....RPIFSALFRM.NRR.ERQHASPLRRLLAEAGIVYSELQDAWTNA...K..KDGLEHLMKEKLP.TVD.EKKMEDLMIILERH............
A0A0L7QRE5_9HYME/268-340             .....KPIFEFFFRI.NRR.ERQHASPLRRLLAEAGIEYTQLQEAWSNG...K..KEGLENLIKEKLT.TIE.EKKVEDLLFVLESH............
A0A0L7KXY6_9NEOP/111-175             dmvet----------.---.ARAWARPVRRLLADAGLLYDQLQTSWEQN...Q..LAGLEKELGELSV.SAK.EEDIKELIEIFDCH............
E0VAW5_PEDHC/259-333                 .....RPIFGDMFSS.RMRlERNRANTLRRLIAEANLTYENLEEAWKKD...K..KESLTALVKERIT.TAKkPEDLDDLTETLLRH............
A0A2J7QQD4_9NEOP/81-153              .....RPVFGPLLRL.NRR.ERQRASNLRRILAEAGIDYPMLSATYSKN...G..KESIAQLLASKLA.QAK.PKEVDELHELLVGH............
A0A087ZTV1_APIME/267-339             .....RPIFGVLFRV.NRR.ERQHASPLRRLLAEAGIEYSQLQEAWSNG...K..KEGLDKLIKEKLT.ATD.EKKIEDVLIVLEGH............
E9HXI3_DAPPU/51-111                  .....RPVFADIFRQ.GIK.PRRRAGFLRHMLVESGITYAGLTETFKDK...K..DDGVVG-------.---.--------------sskrtskarmkp
E9HU85_DAPPU/263-335                 .....RPVFADMFRQ.GIK.PRRRAEFLRHMLVESGITYAGLTETFKDK...K..DDGVVEVIKENIN.GKN.EADVEEFIKLLNQH............
B4HQN5_DROSE/325-396                 .....RPVFLNYFKT.TLY.HRVRAVKFRIVLAENGFDLNKLSAIWAEK...Q..TEGLDMAL-QSIG.RLK.IKDKTELLELLDSY............
A0A653CZM7_CALMS/271-343             .....RPVFGALMRA.SRT.ERQHASHLRRLLAENDINYDKLKMAYDEN...A..KEGLEKIIKAEVT.NGE.EKDIEELLNILDCF............
A0A026X1U4_OOCBI/271-343             .....RPIFSALFRM.NRR.ERQHASPLRRLLAEAGIVYSELQDAWTNA...K..KEGLESLVKEKLP.KVD.EKKLEDLMTILERH............
E9GSP2_DAPPU/199-264                 .....RPVFADIFHQ.GIK.PRRRAGFLRHMLVESGITYAGLTETFKDK...K..DDGVVEVIKENIK.GKN.EADVEE--------p...........
EXU_DROVI/300-371                    .....RPVFLNYFKT.TLY.HRVRAVKFRIVLAENGFDLTTLNDIWTEK...R..IEGLDAAL-QGIA.SLK.AEDKNELVELLDSF............
E9HAV7_DAPPU/579-651                 .....RPVFADMFRQ.GIK.PRRRAEFLRHMLVESGITYAGLTETFKDK...K..DDGVVEVIKENIN.GKN.EADVEEVIKLLNQH............
B0WUE0_CULQU/304-374                 .....RPVFLQYFKT.TIY.HR-QAVTYRRVLAEYGHDFESLRQIWTES...K..REGLEQVI-AKLT.ELK.EDERTELCELLDCH............
A0A484AVC6_DRONA/252-322             .....RPLFVNYFKT.TV-.QRMRAVKFRIALAEGGLDLSTLSDVWKDS...R..IQGLISTL-QPVG.RLT.DGEKTELVALLDSY............
A0A2W1B9I5_HELAM/271-321             .....RPVFAPLLRS.ARP.ERKRVTQLRRLLADAGLLYDQLKDAWQEQ...K..LVG----------.---.--------------edhay.......
B4K0P3_DROGR/295-366                 .....RPVFLHYFKT.TLY.HRVRAVKFRIVLAENGFDLTTFRDIWTDK...H..SEGLHAAL-QGID.SLK.AEDKCELVGLLDSF............
A0A5E4PPM0_9NEOP/251-323             .....RPIFAPLLHL.ARP.ERRRVTHLRRMLADAGLLYEHLQQAWEEQ...R..LTGLEKQLAALST.KAK.EEDMKELIEILDCH............
E2AQD8_CAMFO/266-338                 .....RPIFSALFRM.NRR.ERQHASPLRRLLAEAGIVYSELQDAWTNS...K..KDGLEHLMKEKLP.KVD.EKKLEDLMIILERH............
A0A0T6B4S9_9SCAR/265-337             .....KPVFGALLRA.TPV.ERQHASHLRRILAENKIDYDKLKNAFETD...S..KDGLEKLLKAEIS.NAK.EEDLANLLEILDCF............
J9JXF7_ACYPI/271-341                 slsyq---------T.STL.DRKKAISYRNSIAKANIDYITLQSLWTEN...KenKDGFKDAVKDKLP.ELS.DEEKEGIVS-----tiimh.......
E9HMJ0_DAPPU/276-348                 .....RPVFADMFHQ.GIK.PRRRAGFLRHMLVESGITYAGLTETFKDK...K..DDGVVEVIKENIK.GKN.EADVEEVIKLLNQH............
E9HYX0_DAPPU/261-303                 .....RPVFADMFHQ.GIK.PRRRAGFLRHMLVESGITYAGLTETFK--...-..-------------.---.--------------vsl.........
Q16TW3_AEDAE/385-456                 .....RPVFLQYFKT.TIY.HRVKAVTYRRVLAEYGHDFASLQQVWNDS...K..REGLEAVV-NKIT.ELK.EEERTELVELLDCH............
E9HTE1_DAPPU/189-261                 .....RPVFTDMFRQ.GIK.PRRRAEFLRHMLVESGITYAGLTETFKDK...K..DDGVVEVIKENIN.GKN.EADVEEVIKLLNQH............
EXU2_DROPS/306-377                   .....RPVFLNYFRT.TLN.YRVRAVKYRIGLAEHGFTLKSLKAIWSDK...R..KPGLELVL-TAID.SLK.TEETAELLDLLDSY............
B4M2F2_DROVI/260-330                 .....RPLFLNYFKT.TV-.HRVRAVKFRILLAENGLDLGILNEIWNEI...R..MQGLISTL-APIE.SLT.SKEKTELVILMDSY............
A0A195F464_9HYME/266-338             .....RPIFSALFRM.NRR.ERQHASPLRRLLAEAGIVYSELQDAWTNA...K..KDGLEHLMKEKLP.TVE.EKKMEDLMIILERH............
A0A0Q9X7F8_DROMO/308-379             .....RPVFLNYFKT.TLY.HRVRAVKFRIVLAENGFDLTTLNDIWTEK...R..TEGLDAAL-QGIA.SLK.TEDKNELVELLDSF............
E9GUY9_DAPPU/268-343                 .....RPVFADIFRQ.GIK.PRRRAGFLRHMLVESGITYAGLTETFKVNltrK..MTVWSRSSKRTSK.GKN.EADVEEVIKLLNQH............
A0A1J1ITK6_9DIPT/249-320             .....REVFRSYFQT.SRF.HRRRAVTFRRVLAEGKYDMESLQKMWTDG...K..RDAIVEAV-KKLE.TLK.EDEFDELVDILDSH............
A0A1J1I8J0_9DIPT/53-116              .....REVFRSYFLT.SRF.HRRHAIKFHRVLAEGKYDMENFQNTWNDG...K..RDIIDETI-KKLD.SSN.--------------kmnlmn......
B4GYD4_DROPE/268-339                 .....RPVFLNYFRT.TLN.YRVRAVKYRIALAEHGFTLKSLKAIWSDK...R..KPGLELVL-TAID.SLK.TEETAELLDLLDSY............
A0A6A4KJT8_APOLU/309-379             .....KPIFEHLIKI.SS-.ERKRAIVLRQYLTDANIDFQSLNLVVKEE...K..D--MKQYLHSKIGgELP.EKDLSDLETVVTKH............
A0A4S2JTY0_9HYME/273-345             .....RPIFSALFRM.NRR.ERQHASPLRRLLAEAGIVYSELQDAWTNA...K..KDGLEHLMKEKLP.TVE.EKKMEDLMIILERH............
A0A195E3K0_9HYME/266-338             .....RPIFSALFRM.NRR.ERQHASPLRRLLAEAGIVYSELQDAWTNA...K..KDGLEHLMKEKLP.TVE.EKKMEDLMIILERH............
A0A6I8VHI8_DROPS/306-377             .....RPVFLNYFRT.TLN.YRVRAVKYRIALAEHGFTLKSLKAIWSDK...R..KPGLELVL-TAID.SLK.TEETAELLDLLDSY............
B4GYD7_DROPE/137-208                 .....RPVFLNYFRT.TLN.YRVRAVKYRIALAEHGFTLKSLKAIWSDK...R..KPGLELVL-TAID.SLK.TEETAELLDLLDSY............
A0A1S4E8I1_DIACI/269-343             .....KPVFYFGLKTkNYK.DRQQVMQLRSYVTNALIDYEQLQNVWTNQ..nG..KEGIEQLINTKLS.EVE.EKDRETIIDY----ivkh........
A0A2A4JK56_HELVI/271-343             .....RPVFAPLLRS.ARP.ERKRVTQLRRLLADAGLLYDQLKDAWQEQ...K..LVGLEKQMSSLTV.SAK.EEDIKELIEIFDCH............
A0A182XYN5_ANOST/195-261             aeekc----------.TKT.IKVKAVTYRRVLAESGHDYESLRQLWQEK...K..REGVEAVI-NEIA.ELK.EDERSELVELLDCH............
A0A553NNW8_TIGCA/278-349             .....RPIFESQLKQ.RRS.LKEKAMTLRSLVADAGVDIDELTRVYHEQ...K..DEA-KSVLQNRIE.KAS.ESDIDKLVELMKSH............
H9JWT2_BOMMO/244-316                 .....RPVFAPLLRG.ARG.ERRRVTQLRRLLADHGLLYQQLHDAWEKQ...Q..LAGLEKQLSALSV.SAK.EEDIKELIEILDSH............
E9HX57_DAPPU/158-230                 .....RPVFADMFHQ.GIK.PRRRAGFLRHLLVESGITYAGLTETFKDK...K..DDGVVEVIKENIK.GKN.EADVEEVIKLLNQH............
W5JWG6_ANODA/360-431                 .....RPVFLLYFKT.TIY.HRVKAVTYRRVLAEIGHDYESLRKVWQES...K..REGMEAIV-NKII.ELK.EEERTELTELLDCH............
A0A2J7QQC9_9NEOP/263-335             .....RPVFGPLLRL.NRR.ERQRASNLRRILAEAGIDYPMLSATYSKN...G..KESIAQLLASKLA.QAK.PKEVDELHELLVGH............
A0A1W4WW29_AGRPL/267-339             .....KPVFGALLRA.TRS.ERVHASHLRRLLAENNIDYEKLKTAYQTS...A..RQGIEKILKDEVP.NAK.EKDITELLEILDCF............
B4J965_DROGR/295-366                 .....RPVFLHYFKT.TLY.HRVRAVKFRIVLAENGFDLTTFRDIWTDK...H..SEGLHAAL-QGID.SLK.AEDKCELVGLLDSF............
A0A5E4MZM6_9HEMI/274-341             ..sls-------FHS.STA.DRKKAIGYRNSIAKANIDYMTLQNLWTEN...-..KDGFKDIVKEKLS.GLS.DEEKENIA------isiikh......
A0A194PWP5_PAPXU/289-361             .....RPVFAPLLRA.ARP.ERKRVTQLRRILAEAGFLYEQLRDAWEEH...K..LTGLEKQLGLLSV.SAK.EEDIKELIEIFDCH............
Q7PT28_ANOGA/368-439                 .....RPVFLLYFKT.TIY.HRVKAVTYRRVLAETGHDYESLRQVWQEK...K..REGLEAII-NEIA.ELK.EDERTELNELLDCH............
T1GIA2_MEGSC/259-330                 .....RPVFLQYFKT.TLY.HRVKAVKFRIVLAENGHDLNSLSTIWNEK...R..KEGLAEVI-QNVP.DLK.AEEKTELVDLFDSY............
B4LA16_DROMO/257-327                 .....RPLFVNYFKT.TV-.QRVRAVKFRIALAENGLDLTILSDIWKDL...R..IQGLITTL-EPIG.RLT.DSEKTELVAVLDSY............
A0A3B0JKP7_DROGU/236-307             .....RPLFLNYFRN.TLY.HRVRAVKFRIVLAENGFTLDSLNDIWTEK...G..KEGLDLAL-AAID.TLK.DEEKTELLDLLDSF............
A0A653D1B1_CALMS/193-265             .....RPVFGALMRA.SRT.ERQHASHLRRLLAENDINYDKLKMAYDEN...A..KEGLEKIIKAEVT.NGE.EKDIEELLNILDCF............
E9HHX2_DAPPU/225-290                 ..avq----------.RIK.PRRRAEFLRHMLVESGITYAGLTETLKDK...K..DDGVVEVIKENIN.GKN.EADVEEVIKLLNQH............
E9G1V1_DAPPU/77-149                  .....RPVFADMFHQ.GIK.PRRRAGFLRHMLVESGITYAGLTETFKDK...K..DDGVVEVIKENIK.GKN.KADVEEVIKLLNQH............
E9G1V0_DAPPU/197-269                 .....RPVFADMFHQ.GIK.PRRRAGFLRHMLVESGITYAGLTETFKDK...K..DDGVVEVIKENIK.GKN.KADVEEVIKLLNQH............
A0A067R7W9_ZOONE/268-340             .....RPVFGPLLSV.NRR.ERQRASNLRRILAEAEIDYPLLTATYSKD...G..KESITQLLASKLT.QVK.PKERDELHELLMGH............
E9GNG4_DAPPU/1-58                    .....------MFRQ.GIK.PRRRAEFLRHMLVESGITYAGLTETFKDK...K..DDGVVEVIKENIN.GKN.EADI----------l...........
A0A3B0JE28_DROGU/47-114              ..qns-------FRP.LFL.NRVRAVKFRIVLAENGFTLDSLNAIWTEK...G..KEGLDLAL-AAID.TLK.DEKKTELLGLLDSF............
A0A182XYN5_ANOST/791-862             .....RPVFLLYFKT.TIY.HRVKAVTYRRVLAESGHDYESLRQLWQEK...K..REGVEAVI-NEIA.ELK.EDERSELVELLDCH............
A0A6I8WAF1_DROPS/306-377             .....RPVFLNYFRT.TLN.YRVRAVKYRIALAEHGFTLKSLKAIWSDK...R..KPGLELVL-TAID.SLK.TEETAELLDLLDSY............
B3MIT1_DROAN/310-381                 .....RPVFLNYFKT.TLY.HRVRAVKFRIVLAENGFDLNSLNAIWTDK...R..TEGLDMAL-QSIG.TLK.NEDKTELLELLDSF............
A0A6G0T2Q6_APHGL/581-647             .lsyq---------T.SAL.DRKKAISYRNSIAKANIDYMTLQSLWTEN...-..KDGFKDAVKEKLP.ELS.DDDKENIVT-----tiimh.......
A0A195D162_9HYME/266-338             .....RPIFSALFRM.NRR.ERQHASPLRRLLAEAGIVYSELQDAWTNA...K..KDGLEHLMKEKLP.TVD.EKKMEDLMIILERH............
T1HBK3_RHOPR/234-304                 .....KPIFGQFIRM.DK-.KRRQALILRRHLINSDIEYEMLKEVWT--...R..KEDMKVFLKKNIKdEIS.DDDINDLDFMINKH............
A0A154PRH3_DUFNO/267-339             .....KPIFGVLLRV.NRR.ERQHTSPLRRLLAEAGIEYSQLQEAWSNG...K..KEGLEKLIREKLI.AAE.EKKIEDLLIVLEGH............
A0A158P1F4_ATTCE/266-338             .....RPIFSALFRM.NRR.ERQHASPLRRLLAEAGIVYSELQDAWTNA...K..KDGLEHLMKEKLP.TVE.EKKMEDLMIILERH............
A0A2A3EEB3_APICC/267-339             .....RPIFGVLFRV.NRR.ERQHASPLRRLLAEAGIEYSQLQEAWSNG...K..KEGLDKLIKEKLT.ATD.EKKIEDVLIVLEGH............
N6TK10_DENPD/268-340                 .....RPVFGALMRA.SPT.ERQHASYLRRLLAENNINYDKLKEAYEQG...A..KDALDKILKDEVA.NAK.EEDLIELLEILDCF............
A0A0Q9W9P7_DROVI/300-371             .....RPVFLNYFKT.TLY.HRVRAVKFRIVLAENGFDLTTLNDIWTEK...R..IEGLDAAL-QGIA.SLK.AEDKNELVELLDSF............
A0A1Y1LZ98_PHOPY/264-336             .....RPVFGALMKA.TLP.ERRHASHLRRLLAENNIDYAKLQSAYESS...A..KDGIEGILKNEVP.NAK.EKDLTELLEILDCF............
F4WYK4_ACREC/266-338                 .....RPIFSALFRM.NRR.ERQHASPLRRLLAEAGIVYSELQDAWTNA...K..KDGLEHLMKEKLP.TVE.EKKMEDLMIILERH............
D6WRU5_TRICA/268-340                 .....RPVFGALLRA.SRP.ERQHATHLRRLLAENNINYDKLKQAYEDG...A..KDGLDKVLKSEVA.NAK.ETELSELLDILDCF............
A0A484BPW4_DRONA/308-379             .....RPVFLNYFKT.TLY.HRVRAVKFRIVLAENGFDLTTLNDIWTEK...R..TEGLDAAL-QGIA.SLK.TEDKNELVELLDSF............
A0A164T201_9CRUS/386-458             .....RPVFADMFRQ.GIK.PRRRAGFLRHLLVESGITYAGVTETFKEK...K..DDGVIEIVKEKIK.GKN.EADVDEVIKLLNQH............
A0A0M8ZV13_9HYME/267-339             .....RPIFVSLFRV.NRR.ERQYASPLRRLLAEAGIEYAQLEEAWNNG...K..KEGLEKLIKENLT.TTD.EKKITDLLVVLEDH............
A0A212FEN1_DANPL/117-189             .....RPVFAPLLRL.ANP.ERKRVTQLRRLLADGGFLYDTLKEAWQEQ...Q..VAGLEKQLSSLTV.SAN.ESDIKELIEIFDCH............
E2C9Q4_HARSA/271-343                 .....RPIFSALFRM.NRR.ERQHASPLRRLLAEAGIEYSELQDAWTNE...K..KDGLEHLLKEKLP.RVE.EKKIDDLLFILERH............
A0A4C1VU95_EUMVA/268-340             .....RPVFAPLLRT.ARL.ERKRVTALRRMLADADILYDQLQDAWQAD...K..VEGLERLLSKLSV.SAK.QEDVKELIEILDCH............
A0A3S2NIW9_CHISP/272-344             .....RPVFAPLLRS.ARP.ERKRVTQLRRLLADAGLLYEQLKDAWQEQ...K..LDGLEKQLASLSV.SAK.EEDIKELIEIFDCH............
A0A310SQF0_9HYME/267-339             .....RPIFGFLYRV.NRR.ERQQVSPLRRLLAEAGIEYTQLQDAWSNG...K..KEGLEKLIKEKLT.AAE.EKKVEDLLSVLESH............
B4KR35_DROMO/345-416                 .....RPVFLNYFKT.TLY.HRVRAVKFRIVLAENGFDLTTLNDIWTEK...R..TEGLDAAL-QGIA.SLK.TEDKNELVELLDSF............
E9I2X2_DAPPU/1-50                    .....----------.---.----------MLVESGITYAGLTETLKDK...K..DDGVVEVIKENIN.GKN.EADVEEVIKLLNQH............
E9GJP8_DAPPU/34-99                   .ydaa----------.-PA.PRWRAGFLRHMPVESGITYAGLTETFKDK...K..DDGVVEVIKENIK.GKN.EADVEEVIKLLNQH............
E1JGN9_DROME/325-396                 .....RPVFLNYFKT.TLY.HRVRAVKFRIVLAENGFDLNTLSAIWAEK...N..IEGLDIAL-QSIG.RLK.SKDKAELLELLDSY............
A0A6I8WA49_DROPS/255-326             .....RPVFLNYFRT.TLN.YRVRAVKYRIALAEHGFTLKSLKAIWSDK...R..KPGLELVL-TAID.SLK.TEETAELLDLLDSY............
A0A1D2N4U7_ORCCI/250-323             .....RPIFASKIRR.GRK.DRNRAVILRRYLIDAKLDYEDLSKAFESG...Q..KETVTEVVSTKTQaKKK.EKDMEELIDMI---vtf.........
#=GC SS_cons                         .....TTTTHCHHHH.-HH.HHHHHHHHHHHHHHTT--HHHHHHHHH--...-..--THHHHH-HT-T.T--.HHHHHHHHHHHHTT............
#=GC seq_cons                        .....RPVFhshF+t.shh.cRp+AsthR+lLAEuGlsYspLpcsWp-p...+..c-GL-plltppls.shc.-c-hpELlclL-pa............
//
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