#=GF ID   SAM_Ste50p
#=GF AC   PF09235.14
#=GF DE   Ste50p, sterile alpha motif
#=GF PI   Ste50p-SAM;
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1uqv
#=GF GA   21.00 21.00;
#=GF TC   21.00 21.00;
#=GF NC   20.90 20.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF WK   Sterile_alpha_motif
#=GF CL   CL0003
#=GF RN   [1]
#=GF RM   14573615
#=GF RT   Structure of the sterile alpha motif (SAM) domain of the
#=GF RT   Saccharomyces cerevisiae mitogen-activated protein kinase
#=GF RT   pathway-modulating protein STE50 and analysis of its interaction
#=GF RT   with the STE11 SAM. 
#=GF RA   Grimshaw SJ, Mott HR, Stott KM, Nielsen PR, Evetts KA, Hopkins
#=GF RA   LJ, Nietlispach D, Owen D; 
#=GF RL   J Biol Chem. 2004;279:2192-2201.
#=GF DR   INTERPRO; IPR015316;
#=GF DR   SCOP; 1uqv; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The fungal Ste50p SAM domain consists of five helices, which
#=GF CC   form a compact, globular fold. It is required for mediation of
#=GF CC   homodimerisation and heterodimerisation (and in some cases
#=GF CC   oligomerisation) of the protein [1].
#=GF SQ   37
#=GS A0A1G4JVT6_9SACH/10-88      AC A0A1G4JVT6.1
#=GS J7RW15_KAZNA/42-126         AC J7RW15.1
#=GS G8ZQR2_TORDC/22-96          AC G8ZQR2.1
#=GS X6LKC0_RETFI/16-81          AC X6LKC0.1
#=GS H2ATI6_KAZAF/12-86          AC H2ATI6.1
#=GS A0A7H9HQV2_9SACH/42-116     AC A0A7H9HQV2.1
#=GS A0A1U7EQ96_9SACH/29-106     AC A0A1U7EQ96.1
#=GS STE50_YEAST/30-104          AC P25344.1
#=GS A0A1G4JZE5_9SACH/20-96      AC A0A1G4JZE5.1
#=GS A0A2G5TZE9_9PELO/57-104     AC A0A2G5TZE9.1
#=GS A0A261BZX2_9PELO/1029-1105  AC A0A261BZX2.1
#=GS G0W313_NAUDC/65-140         AC G0W313.1
#=GS A0A8J4U8U7_CLAMG/118-181    AC A0A8J4U8U7.1
#=GS Q6FX88_CANGA/16-90          AC Q6FX88.1
#=GS Q751W9_ASHGO/75-129         AC Q751W9.1
#=GS G8JM97_ERECY/97-150         AC G8JM97.1
#=GS A0A7H9AX11_ZYGMR/19-98      AC A0A7H9AX11.1
#=GS A8XQJ2_CAEBR/129-199        AC A8XQJ2.2
#=GS A0A8W8M1V8_CRAGI/12-79      AC A0A8W8M1V8.1
#=GS G0VAU1_NAUCC/37-112         AC G0VAU1.1
#=GS A0A1G4MGI2_LACFM/14-90      AC A0A1G4MGI2.1
#=GS A0A0C7NF16_9SACH/15-106     AC A0A0C7NF16.1
#=GS Q6CUY2_KLULA/2-76           AC Q6CUY2.1
#=GS J4TXQ0_SACK1/30-104         AC J4TXQ0.1
#=GS A7TFA3_VANPO/13-87          AC A7TFA3.1
#=GS G8BQ67_TETPH/17-92          AC G8BQ67.1
#=GS A0A376B6K6_9ASCO/21-101     AC A0A376B6K6.1
#=GS I2GWM0_TETBL/2-68           AC I2GWM0.1
#=GS J9J2Y9_9SPIT/28-82          AC J9J2Y9.1
#=GS J8PQW9_SACAR/30-104         AC J8PQW9.1
#=GS C5DK31_LACTC/14-90          AC C5DK31.1
#=GS A0A4C2E7G9_9SACH/100-174    AC A0A4C2E7G9.1
#=GS A0A8W8LXH0_CRAGI/144-211    AC A0A8W8LXH0.1
#=GS A0A261C0V1_9PELO/1043-1119  AC A0A261C0V1.1
#=GS A0A1X7R366_9SACH/47-121     AC A0A1X7R366.1
#=GS A0A0L0FBG7_9EUKA/186-252    AC A0A0L0FBG7.1
#=GS A0A1S7HLW7_9SACH/29-103     AC A0A1S7HLW7.1
A0A1G4JVT6_9SACH/10-88                 .........................................pev---RSWTTDEVCAWCAEV.LRVED.A........D.A.LsaIED...aVRENNIDGQV.IGDLTLDD..CK.SLV..N.GD..........RR.LAVRFKIELNRLRS---ksqe......................
J7RW15_KAZNA/42-126                    ...........................................g-DWKEWSVENVVSWCQTS.LNLPD.D........D.V.L..CRQ....LAENEITGDL.LPELCLDD..CK.ELC..T.GDngavpavegtVQ.KAIRFKLMINKLVN---eng.......................
G8ZQR2_TORDC/22-96                     ............................................DDFTNWTINEVVAWCTSS.LEITE.E........D.L.L..VEK....IRSNEITGEL.LPELTFED..CK.ELC..G.GD..........LS.KSIRLKVLLNKLQDD--ad........................
X6LKC0_RETFI/16-81                     ..........................................sa--MEQWTVEEVVAWAKTQ.VAETF.Q........E.K.V..MDA....LKKNKVDGRTfVSSITVK-..--.---..-.--..........--.-----------------kdledleipkvaaaqifn........
H2ATI6_KAZAF/12-86                     ...........................................g-DYANWTVDEVVSWCKST.LKLPD.D........N.S.L..CLS....LVENDVSGSI.LKDLTLDD..CK.DLC..D.SN..........LK.LAIKLKISINKLNDTS-a.........................
A0A7H9HQV2_9SACH/42-116                ............................................DDFAKWTVEEVISWCVSS.LEISA.D........D.P.V..VDQ....IRLNGICGEL.LTELTFDD..CK.ELC..C.QD..........VN.KAVRLKVVLNRLQ----ndad......................
A0A1U7EQ96_9SACH/29-106                ..........................................ee--YISWSVEDVVKWCAFS.LEIPE.D........D.A.L..VNQ....LRSNAINGEL.LGELTLDD..CR.ELC..E.GD..........LS.LAIRFKVLLNRLQ----qgvdsdv...................
STE50_YEAST/30-104                     ............................................EDFSQWSVDDVITWCIST.LEVEE.T........D.P.L..CQR....LRENDIVGDL.LPELCLQD..CQ.DLC..D.GD..........LN.KAIKFKILINKMRDSKL..........................
A0A1G4JZE5_9SACH/20-96                 ..........................................ee--LLEWGVDEVLTWCEQK.LAIDE.K........ElP.Q..IRE...rFYQNAIDGPS.VLELDLDD..CK.QLL..N.ED..........AQ.LAVKLKLEINRLKH---qeh.......................
A0A2G5TZE9_9PELO/57-104                ...........................................v-NFQLWSHDQVIVWSKKV.FPGAA.G........T.P.T..IQK....IRNTGIAGDI.LAEVA---..--.---..-.--..........--.-----------------sdp.......................
A0A261BZX2_9PELO/1029-1105             ...........................................h-DYYNWKSADLAAWMKSV.LSLDD.R........D.P.L..LQK....MIDEDMDGLV.LEEFLRDEsvCI.TTL..G.VN..........TG.RSIKIKGAIIKVVN---nra.......................
G0W313_NAUDC/65-140                    ...........................................q-SFMEWSVNDVVKWCFKS.LSLNDiN........D.P.L..IKN....LVDHDISGDV.LDELDIND..CK.DLC..D.HD..........NK.KAIKLQLAFNKLTDTH-p.........................
A0A8J4U8U7_CLAMG/118-181               .........................................pda---SSRSQEEVIKRII-E.LIKQE.G........D.V.I..NDK....LRENTIVSSY.FNTITYGS..FK.QLA..D.QY..........VN.S----------------evpqht....................
Q6FX88_CANGA/16-90                     ............................................DNFDKWTTDEVVQWCGTV.LGKDE.Q........E.P.L..FTR....IRDNNIDGSV.LQELTLQD..CK.ELT..D.ND..........LK.EAIKLKLWLNKLIDSQL..........................
Q751W9_ASHGO/75-129                    .....................................taptlds------------------.-----.-........-.-.-..CRR...nFRQHKITGDV.LPFLTLDD..CK.QLF..D.GD..........AR.LGVKFKIAINGL-----krfe......................
G8JM97_ERECY/97-150                    ...................................idpyssiks------------------.-----.-........-.-.-..--N....FHENAITGDV.LPFLSLED..CK.RVF..N.ND..........TK.LAVKFKVSINKL-----ervt......................
A0A7H9AX11_ZYGMR/19-98                 ............................................DNFKKWSSNEVVTWCVAS.LGLSE.S........D.P.L..AER....LQKNDVSGEL.LTELSLDD..LK.ELC..E.PD..........LD.KAIRFKVLLNKLQ----ydagvdskl.................
A8XQJ2_CAEBR/129-199                   ............................................DDFWHWSKETVLSWMALV.IPQEH.Q........N.G.V..IGR....LREVDLDGGW.LPELA---..--.---..-.--..........--.-----------------keqtiknalnltdtqhmflqgfaikv
A0A8W8M1V8_CRAGI/12-79                 ........................................snpl----KWSVNEVVKFLKT-.---TD.C........A.N.L..ARI....CKEQDIDGQA.LLLLTLPA..VQ.EFM..D.LK..........LG.PAVKFCHQIE-------rvkl......................
G0VAU1_NAUCC/37-112                    ............................................ENYEHWSVQEVVTWCSME.LSLAE.S........D.S.L..CQQ....LKINSISGDV.LSELTMND..CK.ELC..S.ND..........LK.RAIKLKIALNKLISD--qds.......................
A0A1G4MGI2_LACFM/14-90                 ...........................................d-GYVKWSVKEVGEWCAEK.LQLDG.E........D.L.V..KLQe..cIEEQGIDGDI.LDELSLQD..CK.MIT..G.GN..........VG.RAVRLKVELNRLREKK-h.........................
A0A0C7NF16_9SACH/15-106                edvalwgveevliwieqiignfgvenaggegkenakdgpnlakv------------------.-----.-........-.-.-..-QE...nFRENAIDGAS.LLELDLDD..CK.QLM..E.ND..........AK.FAVHLKLEINILR----tqkg......................
Q6CUY2_KLULA/2-76                      ............................................SGTNEWSTEEVCKKVKAE.LGLTD.G........D.T.F..ILD...rIRENKITGST.LSEITLAD..CK.ELC..P.DS..........IS.-AVRLKTCINKFVDTEE..........................
J4TXQ0_SACK1/30-104                    ............................................EDYSQWSVDDVISWCIPT.LEVEE.S........D.V.L..CRN....LRENDIVGDL.LPELSLQD..CQ.ELC..E.DD..........LN.KAIKFKILINKLRDTKL..........................
A7TFA3_VANPO/13-87                     ...........................................v-NCNSWTTQEVVAWCMSS.LGIPQ.D........S.T.L..CNN....LHQHNITGDL.LEELTLED..CK.ELC..G.ND..........RG.LALRFKVLLNKLFESKE..........................
G8BQ67_TETPH/17-92                     ...........................................v-NCSKWSAEDVASWCVST.LDIDN.E........S.E.L..YNN....LIEQEISGDL.LKELSLQD..CK.DLC..GsAN..........LK.LAIKFKLQLNKLL----rken......................
A0A376B6K6_9ASCO/21-101                ...........................................k-DVYTWSIDDVVKWYELV.YKTTT.SnihtniypE.S.V..IVN....LRENKIDGPV.LVKLSLDD..CK.ELT..N.ND..........LK.DAVQMKLQINRAI----qg........................
I2GWM0_TETBL/2-68                      .........................................mdy---ENWSIEETSIWADK-.--FEL.G........D.-.-..--K....FLEHGIDGSL.LKELEMND..CK.EIC..G.GD..........KK.KAVMLKMNLNQLVD---dg........................
J9J2Y9_9SPIT/28-82                     .........................................sqv---INWSLDEVLEWLSAN.---HY.E........D.E.L..IKR....FRDNDIDGSC.LLELNFS-..--.---..-.--..........--.-----------------nemrfstsnln...............
J8PQW9_SACAR/30-104                    ............................................EDYSQWSVDDVITWCIST.LELEK.T........D.P.L..FQK....LRDNDIVGDL.LPELSLQD..CQ.ELC..E.DD..........LN.KAIKFKILINKLRDTK-s.........................
C5DK31_LACTC/14-90                     ..........................................ee--VLNWGIDEVSIWCAQK.LALDG.Gr......rD.K.F..QAN....LKEHGIDGQV.LLDLELED..CK.QLT..D.ND..........SS.LAVQLKLEVNRLRAQ--kq........................
A0A4C2E7G9_9SACH/100-174               ...........................................e-EYTKWSVEDVVKWCVFS.LELQN.D........D.P.L..VDQ....LRKNGINGEL.LGELTLED..CK.ELC..E.DD..........LS.LAIRFKVLCNRLQ----qgvn......................
A0A8W8LXH0_CRAGI/144-211               ........................................snpl----KWSVNEVVKFLKT-.---TD.C........A.N.L..ARI....CKEQDIDGQA.LLLLTLPA..VQ.EFM..D.LK..........LG.PAVKFCHQIE-------rvkl......................
A0A261C0V1_9PELO/1043-1119             ...........................................h-DYYNWKSADLAAWMKSV.LSLDD.R........D.P.L..LQK....MIDEDMDGLV.LEEFLRDEsvCI.TTL..G.VN..........TG.RSIKIKGAIIKVVN---nra.......................
A0A1X7R366_9SACH/47-121                ...........................................s-NYELWTVDEVINWCIPL.LDITE.D........H.P.L..ISN....IQLNNIDGDV.INDLSFED..CK.ELC..N.GS..........LQ.DTIKLRLALNKLKDN--ns........................
A0A0L0FBG7_9EUKA/186-252               ...........................................s-DPNEWTVDDVVRWCRNC.----E.M........D.D.A..VEV....IAENGINGQV.LLSLTDKD..QV.---..-.--..........--.-----------------alglnkfgtrrglqielsrlv.....
A0A1S7HLW7_9SACH/29-103                ...........................................e-EYTSWSVEDVVKWCVFS.LEIPE.D........N.A.L..VNQ....LHSNAINGEL.LGELTLDD..CK.ELC..E.GN..........LS.LAIRFKVLLNRLQ----qgvd......................
#=GC seq_cons                          .............................................th.pWol--VlpWshts.Ltlsc.s........-.s.l..hpp....l+-NsIsGsl.LsELoLpD..CK.cLs..s.sc..........hp.hAl+hKl.lN+L.....pt........................
//