#=GF ID   SH3_14
#=GF AC   PF18343.4
#=GF DE   Dda helicase SH3 domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00924
#=GF GA   111.30 111.30;
#=GF TC   121.40 121.30;
#=GF NC   109.00 105.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0010
#=GF RN   [1]
#=GF RM   22658750
#=GF RT   The T4 phage SF1B helicase Dda is structurally optimized to
#=GF RT   perform DNA strand separation.
#=GF RA   He X, Byrd AK, Yun MK, Pemble CW 4th, Harrison D, Yeruva L, Dahl
#=GF RA   C, Kreuzer KN, Raney KD, White SW;
#=GF RL   Structure. 2012;20:1189-1200.
#=GF DR   INTERPRO; IPR041214;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a Src homology-3 (SH3) like beta-barrel domain which can
#=GF CC   be found in Dda enzyme. Dda is a phage T4 SF1B helicase. The Dda
#=GF CC   SH3 domain contains two insertions (compared to RecD2), a second
#=GF CC   beta-ribbon that is referred to as the hook and a
#=GF CC   beta-ribbon/two-helix substructure that is referred to as the
#=GF CC   tower. The tower region within the domain is rigidly connected
#=GF CC   to domain 2A in Dda and appears to be specifically designed for
#=GF CC   the task of supporting the extended pin. Hence, it is suggested
#=GF CC   that 2A and this SH3 domain move as one unit during the
#=GF CC   ATP-driven translocation of ssDNA while maintaining contact with
#=GF CC   the pin. In this scenario, the pin-tower interaction can be
#=GF CC   considered as an additional transmission site that serves to
#=GF CC   more efficiently couple the energy from ATP binding and
#=GF CC   hydrolysis to the unwinding of dsDNA [1].
#=GF SQ   39
#=GS A0A5P8PJZ1_9CAUD/262-392  AC A0A5P8PJZ1.1
#=GS A0A386K6Z1_9CAUD/263-393  AC A0A386K6Z1.1
#=GS A0A0A0YT70_9CAUD/262-392  AC A0A0A0YT70.1
#=GS A0A7G8LBD7_9CAUD/250-371  AC A0A7G8LBD7.1
#=GS I7J3V8_9CAUD/261-389      AC I7J3V8.1
#=GS A0A2H4YFE8_9CAUD/262-392  AC A0A2H4YFE8.1
#=GS A0A7D7ISA8_9CAUD/262-392  AC A0A7D7ISA8.1
#=GS E3SFA5_9CAUD/262-392      AC E3SFA5.1
#=GS A0A0A0Q3A4_9CAUD/264-394  AC A0A0A0Q3A4.1
#=GS A0A1Z1LY03_9CAUD/260-391  AC A0A1Z1LY03.1
#=GS A0A126HHJ8_9CAUD/250-371  AC A0A126HHJ8.1
#=GS E5FID0_9CAUD/262-392      AC E5FID0.1
#=GS A0A482MVS5_9CAUD/257-387  AC A0A482MVS5.1
#=GS R9TGH5_9CAUD/250-371      AC R9TGH5.1
#=GS DDA_BPT4/260-389          AC P32270.2
#=GS DDA_BPT4/260-389          DR PDB; 3UPU B; 260-389;
#=GS DDA_BPT4/260-389          DR PDB; 3UPU A; 260-389;
#=GS DDA_BPT4/260-389          DR PDB; 3UPU C; 260-389;
#=GS A0A088FVJ1_9CAUD/257-387  AC A0A088FVJ1.1
#=GS W6ASY7_9CAUD/263-393      AC W6ASY7.1
#=GS D7RM26_9CAUD/265-395      AC D7RM26.1
#=GS Q6WHZ8_BPKVM/240-361      AC Q6WHZ8.1
#=GS A0A3G2KBT9_9CAUD/257-387  AC A0A3G2KBT9.1
#=GS A0A2K9VMG7_9CAUD/260-389  AC A0A2K9VMG7.1
#=GS A0A346FJA2_BPT6/260-389   AC A0A346FJA2.1
#=GS A0A2Z5ZC85_9CAUD/260-391  AC A0A2Z5ZC85.1
#=GS Q7Y5C3_BPR69/257-387      AC Q7Y5C3.1
#=GS E5DI28_9CAUD/257-387      AC E5DI28.1
#=GS A0A5B9NBB2_9CAUD/263-393  AC A0A5B9NBB2.1
#=GS A0A3T0IM64_9CAUD/143-273  AC A0A3T0IM64.1
#=GS M1EA88_9CAUD/261-390      AC M1EA88.1
#=GS C3V204_BPR51/260-389      AC C3V204.1
#=GS A0A7G8AKP8_9CAUD/257-387  AC A0A7G8AKP8.1
#=GS A0A4Y5TQL1_9CAUD/262-392  AC A0A4Y5TQL1.1
#=GS A0A2S1GM41_9CAUD/265-393  AC A0A2S1GM41.1
#=GS A0A5B7LFN5_9CAUD/247-377  AC A0A5B7LFN5.1
#=GS A0A482JP83_9CAUD/263-393  AC A0A482JP83.1
#=GS A8R8V4_9CAUD/263-393      AC A8R8V4.1
#=GS A0A386K5D0_9CAUD/257-387  AC A0A386K5D0.1
#=GS A0A2I6UFQ6_9CAUD/262-392  AC A0A2I6UFQ6.1
#=GS A0A1B0VV18_9CAUD/262-391  AC A0A1B0VV18.1
#=GS A0A6H0X803_9CAUD/240-361  AC A0A6H0X803.1
A0A5P8PJZ1_9CAUD/262-392             .e-DAFITGEVIVMQEPLIKELEFEGK.RFNDLKFNNGQYVRIVSAEYVSSFVSCKGVSGEYML...RHWRLTVETY.D.K.DeD.YHLETINVISDEQEQNKFQFFLAKAADTYRNWQKGG.KAP.WKSFWAAKRMFHKVK-p
A0A386K6Z1_9CAUD/263-393             ..DRPFVVGEIVVMQEPLTKELKFEGK.KFSEILFNNGQFVRILDAVETTTFLGARGVPGEYLV...RHWVLDIETY.G.D.DeE.YAREKICVISSEEEMNKFQFFLAKTADTYKNWNKGG.KAP.WSEFWDAKRKFHKVKA.
A0A0A0YT70_9CAUD/262-392             .e-DAFIAGEIIVMQEPLMRELMYDGK.KFTETLFNNGQYVRILDAQYTSTFLGAKGVSGEHLI...RHWVLDVETY.G.D.DeE.YAREQIRVISDEQEMNKFQFFLAKAADTYKNWNKGG.KAP.WSEFWEAKRKFHKVKA.
A0A7G8LBD7_9CAUD/250-371             ..SEPFIPNEYLVTQMPVMQS---NGKyPVC--VIDNGEIVKILD-------VRQKTIDGMLPKvdnESFDVAVLTV.E.K.D.D.GNVYEFTVLWDDLQKERFARYLMVAAGTYKSMRGNT.KRY.WRAFWGLKEQMIETKS.
I7J3V8_9CAUD/261-389                 ..DKPFINGEVLVMQEPLMKELEFDGK.KFHEIVFNNGQLVKILYASETSTFISARNVPGEYMI...RYWNLEVETA.DsD.D.D.YATSQIQVICDPAEMTKFQMFLAKTADTYKN--SGV.KAY.WKDFWSVKNKFKKVKA.
A0A2H4YFE8_9CAUD/262-392             .e-DAFIAGEIIVMQEPLMRELMYDGK.KFTETLFNNGQYVRILDAQYTSTFLGAKGVSGEHLI...RHWVLDVETY.G.D.D.EeYVREQIRVISDEQEMNKFQFFLAKAADTYKNWNKGG.KAP.WSEFWEAKRKFHKVKA.
A0A7D7ISA8_9CAUD/262-392             ..DKAFLPYEVLVMQEPHMKELEFEGK.KFSETIFNNGQLVRIKDCKYTSTILRCKGESHQLVI...NYWDLEVESIdE.D.E.E.YQVDRIKVLPEDQQ-PKFQAYLAKVADTYKQMKAAG.KRPeWKDFWKARRTFLKVRA.
E3SFA5_9CAUD/262-392                 ..DKAFLPYEVLVMQEPHMKELEFEGK.KFSETIFNNGQLVRIKDCKYTSTILRCKGESHQLVI...NYWDLEVESIdE.D.E.E.YQVDRIKVLPEDQQ-PKFQAYLAKVADTYKQMKAAG.KRPeWKDFWKARRTFLKVRA.
A0A0A0Q3A4_9CAUD/264-394             et--SFIKDEIIVMQEPMIKELEFDGK.KFSETIFNNGQLVRIKDAMLTSGFLSARNVSTRQMI...NYWSLEVETA.E.D.D.E.EYRVDVIKFLPADQVEKFNYFLAKTATTYREMKNAGkKAP.WEDFWKAKRTFLKVRA.
A0A1Z1LY03_9CAUD/260-391             .e-SPFIVGEVLVMQEPYMKSLEFDGK.KFNEIIFNNGQMVRILDCKLTSTFLKARDVSVKQMI...SYWHLEVETV.DeD.D.D.YQRETIKVLADDNEKQKFDMFLAKVATSYRELKSAG.RRPhWADFWDAKRTFLKVKA.
A0A126HHJ8_9CAUD/250-371             ..SEPFIPNEYLVTQMPVMQS---NGKyPVC--VIDNGEIVKILD-------VRQKTIDGMLPKvdnESFDVAVLTV.E.K.D.D.GNVYEFTVLWDDLQKERFARYLMVAAGTYKSMRGNT.KRY.WRAFWGLKEQMIETKS.
E5FID0_9CAUD/262-392                 ..DKAFLPYEVLVMQEPHMKELEFEGK.KFSETIFNNGQLVRIKDCKYTSTILRCKGESHQLVI...NYWDLEVESIdE.D.E.E.YQVDRIKVLPEDQQ-PKFQAFLAKVADTYKQMKAAG.KRPeWKDFWKARRTFLKVRA.
A0A482MVS5_9CAUD/257-387             ..EKPFIKDEVIVLQEPFTKTYKLDGK.NMTEMLFNNGQFVRIRDAVETSTFVKARGVSGEYMI...RYWNLTVETY.G.D.D.EeYIREDIKVISSEEELYKFNLFLAKTAETYKFWNKGG.KAP.WSEFWDAKRMFTKVKA.
R9TGH5_9CAUD/250-371                 .t-EPFIPNEYLVTQMPVMVS---TGKyPVC--VIENGEVVKILD-------VRQKTIDGMLPKvdnESFDVAVLTV.E.K.E.N.GTVYEFTVLWDDLQKERFARYLSVAAGTYKSMRGNT.KRY.WRAFWGLKEQMIETKS.
DDA_BPT4/260-389                     ..DKDFIVGEIIVMQEPLFKTYKIDGK.PVSEIIFNNGQLVRIIEAEYTSTFVKARGVPGEYLI...RHWDLTVETY.G.D.D.E.YYREKIKIISSDEELYKFNLFLAKTAETYKNWNKGG.KAP.WSDFWDAKSQFSKVKA.
#=GR DDA_BPT4/260-389          SS    ..S-SS-TT-EEEESS-EEEEEEETTE.EEEEEEE-TT-EEEEEEEEEEEEEE--TTSSS-EEE...EEEEEEEEEE.S.S.S.-.--EEEEEE--SHHHHHHHHHHHHHHHHHHHS--SSS.S--.THHHHHHHTTEE-EEE.
A0A088FVJ1_9CAUD/257-387             ..EKPFIKDEVIVLQEPFTKTYKLDGK.NMTEMLFNNGQFVRIRDAVETSTFVKARGVSGEYMI...RYWNLTVETY.G.D.D.EeYVREDIKVISSEEELYKFNLFLAKTAETYKFWNKGG.KAP.WSEFWDAKRMFTKVKA.
W6ASY7_9CAUD/263-393                 .e-EPFIVGEVVVMQEPLIKELEYDGK.KFSEVIFNNGQYVRILSCKESSDFIGAKGVPGEYMV...RHWDLELETY.G.DeD.D.YYRETIRVIADEQEQNKFQFFLAKAADTYKNWNKGG.KAP.WKDFWAAKRRYHKVKA.
D7RM26_9CAUD/265-395                 ..DAPYIKGEILVMQEPFMKELEYDGK.KFSETIFNNGQMVRILDVNHTSLFLSAKDVGTRQMI...NYWDLQVESVdE.D.D.E.YYVEHLKVI-DEASVEKFHYFLAKVATEYKAMRGTG.KKPkWADFWKAKRMFTKVRA.
Q6WHZ8_BPKVM/240-361                 ..SEPFIPGEYLVTQMPVMVS---NGKyPVC--VIENGEVVKILD-------VRQKTIDGMLPKvdnEAFDVAVLTV.E.K.E.D.GNVYEFTVLWDDLQKERFARYLSVAAGTYKSMRGNT.KRY.WRAFWGLKEQMIETKS.
A0A3G2KBT9_9CAUD/257-387             ..EKPFIKDEVIVLQEPFTKTYKLDGK.NMTEMLFNNGQFVRIRDAVETSTFVKARGVSGEYMI...RYWNLTVETY.G.D.D.EeYVREDIKVISSEEELYKFNLFLAKTAETYKFWNKGG.KAP.WSEFWDAKRMFTKVKA.
A0A2K9VMG7_9CAUD/260-389             ..DKDFIVGEIIVMQEPLIKTYKIDGK.PVSEIIFNNGQLVRIIEAEYTSTFVKARGVPGEYLI...RHWDLTVETY.G.D.D.E.YYREKIKIISSDEELYKFNLFLGKTAETYKNWNKGG.KAP.WSDFWDAKSQFSKVKA.
A0A346FJA2_BPT6/260-389              ..DKDFIVGEIIVMQEPLIKTYKIDGK.PVSEIIFNNGQLVRIIEAEYTSTFVKARGVPGEYLI...RHWDLTVETY.G.D.D.E.YYREKIKIISSDEELYKFNLFLGKTAETYKNWNKGG.KAP.WSDFWDAKSQFSKVKA.
A0A2Z5ZC85_9CAUD/260-391             .e-NPFIVGEVLVMQEPYMKQLEFDGK.KFNEIIFNNGQMIRILDCKLTSTFLKARDVSVKQMI...SYWHLEVETV.DeD.D.D.YQRETIKVLADANEKQKFDMFLAKVATTYRELKSAG.RRPhWADFWDAKRTFLKVKA.
Q7Y5C3_BPR69/257-387                 ..EKPFIKDEVIVLQEPFTKTYKLDGK.NMTEMLFNNGQFVRIRDAVETSTFVKARGVSGEYMI...RYWNLTVETY.G.D.D.EeYIREDIKVISSEEELYKFNLFLAKTAETYKFWNKGG.KAP.WSEFWDAKRMFTKVKA.
E5DI28_9CAUD/257-387                 .e-EPFIVGEVVVMQEPLIKELEYDGK.KFSEVIFNNGQYVRILSCKESSDFIGAKGVPGEYMV...RHWDLELETY.G.DeD.D.YYRETIRVIADEQEQNKFQFFLAKAADTYKNWNKGG.KAP.WKDFWAAKRRYHKVKA.
A0A5B9NBB2_9CAUD/263-393             .e-RPFVVGEIVVMQEPLTKELKFEGK.KFSEILFNNGQFVRILDAVETTSFLGARGVPGEYLV...RHWVLDIETY.G.D.DeE.YAREKICVISSEEEMNKFQFFLAKTADTYKNWNKGG.KAP.WSEFWDAKRKFHKVKA.
A0A3T0IM64_9CAUD/143-273             ..DAPYIKGEILVMQEPFIKELEYDGK.KFSETIFNNGQMVRILDVNHTSLFLSAKDVGTRQMI...NYWDLQVESVdE.D.D.E.YYVEHLKVI-DEASVEKFHYFLAKVATEYKAMRGSG.KKPkWADFWKAKRMFTKVRA.
M1EA88_9CAUD/261-390                 .e-EAFVVGEVIVMQEPLMRELVFEGK.KFHETLFTNGQYVRILSADYTSSFLGAKGVSGEHLI...RHWVLDVETY.D.D.E.E.YAREKINVISDEQEMNKFQFFLAKTADTYKNWNKGG.KAP.WSEFWDAKRKFHKVKA.
C3V204_BPR51/260-389                 ..DKDFIVGEIIVMQEPLIKTYKIDGK.PVSEIIFNNGQLVRIIEAEYTSTFVKARGVPGEYLI...RHWDLTVETY.G.D.D.E.YYREKIKIISSDEELYKFNLFLGKTAETYKNWNKGG.KAP.WSDFWDAKSQFSKVKA.
A0A7G8AKP8_9CAUD/257-387             ..EKPFIKDEVIVLQEPFTKTYKLDGK.NMTEMLFNNGQFVRIRDAVETSTFVKARGVSGEYMI...RYWNLTVETY.G.D.D.EeYIREDIKVISSEEELYKFNLFLAKTAETYKFWNKGG.KAP.WSEFWDAKRMFTKVKA.
A0A4Y5TQL1_9CAUD/262-392             .e-DAFIKGEVIVMQEPLIKELEFEGK.RFNDLKFNNGQYVRIVSAEYVSSFVSCTGVSGEYML...RHWRLAVETY.D.K.DeD.YHLETINVISDEQEQNKFQFFLAKAADTYRNWQKGG.KAP.WKSFWAAKRMFHKVK-p
A0A2S1GM41_9CAUD/265-393             .e-DPFVVNEVLVMQEPLTKEIKFEGK.RFSEMIFHNGQMVRVVKAEKTSKFLRAKGVSGEQMI...RYWSLVVETN.DaE.D.E.YFREQICVLSDENEINKYYYFLAKVADAYKS--GAV.KAH.WADFWAAKRAFIKVKA.
A0A5B7LFN5_9CAUD/247-377             .e-RPFVVGEIVVMQEPLTKELKFEGK.KFSEILFNNGQFVRILDAVETTTFLGARGVPGEYLV...RHWVLDIETY.G.D.DeE.YAREKICVISSEEEMNKFQFFLAKTADTYKNWNKGG.KAP.WSEFWDAKRKFHKVKA.
A0A482JP83_9CAUD/263-393             ..DAPYIKGEILVMQEPFMKELEYDGK.KFSETIFNNGQMVRILDVNHTSLFLSAKDVGTRQMI...NYWDLQVESVdE.D.D.E.YYVEHLKVI-DEASVEKFHYFLAKVATEYKAMRGTG.KKPkWADFWKAKRMFTKVRA.
A8R8V4_9CAUD/263-393                 ..DAPYIKGEILVMQEPFIKELEYDGK.KFSETIFNNGQMVRILDVNHTSLFLSAKDVGTRQMI...NYWDLQVESVdE.D.D.E.YYVEHLKVI-DEASVEKFHYFLAKVATEYKAMRGTG.KKPkWADFWKAKRMFTKVRA.
A0A386K5D0_9CAUD/257-387             ..EKPFIKDEVIVLQEPFTKTYKLDGK.NITEMLFNNGQFVRIRDAVETSTFVKARGVSGEYMI...RYWNLTVETY.G.D.D.EeYIREDIKVISSEEELYKFNLFLAKTAETYKFWNKGG.KAP.WSEFWDAKRMFTKVKA.
A0A2I6UFQ6_9CAUD/262-392             .e-DAFITGEVIVMQEPLIKELEFEGK.RFNDLKFNNGQYVRIVSAEYVSSFVSCKGVSGEYML...RHWRLTVETY.D.K.DeD.YHLETINVISDEQEQNKFQFFLAKAADTYRNWQKGG.KAP.WKSFWAAKRMFHKVK-p
A0A1B0VV18_9CAUD/262-391             .e-EAFVIGEVIVMQEPLMRELVFEGK.KFHETLFTNGQYVRILSADYTSSFLGAKGVSGEHLI...RHWVLDVETY.D.D.E.E.YAREKINVISDEQEMNKFQFFLAKTADTYKNWNKGG.KAP.WSEFWDAKRKFHKVKA.
A0A6H0X803_9CAUD/240-361             ..SEPFIPGEYLVTQMPVMVS---NGKyPVC--VIENGEVVKILD-------VRQKTIDGMLPKvdnEAFDVAVLTV.E.K.E.D.GNVYEFTVLWDDLQKERFARYLSVAAGTYKSMRGNT.KRY.WRAFWGLKEQMIETKS.
#=GC SS_cons                         ..S-SS-TT-EEEESS-EEEEEEETTE.EEEEEEE-TT-EEEEEEEEEEEEEE--TTSSS-EEE...EEEEEEEEEE.S.S.S.-.--EEEEEE--SHHHHHHHHHHHHHHHHHHHS--SSS.S--.THHHHHHHTTEE-EEE.
#=GC seq_cons                        ...cPFIsGEllVMQEPhhKplca-GK.+FoEhlFNNGQhVRIlDsp.TSoFlpA+GVuGEhhI...RaWsLsVETh.s.D.D.E.YhpEcIpVIu--pEhpKFphFLAKsA-TYKshppuG.KAP.Wu-FWcAKRpFpKVKA.
//