#=GF ID SHU2
#=GF AC PF29629.1
#=GF DE Suppressor of hydroxyurea sensitivity protein 2
#=GF AU Morveli N;0000-0003-2496-881X
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE TED:A7TGA7_TED01
#=GF GA 27.00 27.00;
#=GF TC 27.10 27.60;
#=GF NC 26.90 26.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RC Function description for P38957
#=GF RN [1]
#=GF RM 12972632
#=GF RT "A genomewide screen in Saccharomyces cerevisiae for genes that
#=GF RT suppress the accumulation of mutations.";
#=GF RA Huang M.-E., Rio A.-G., Nicolas A., Kolodner R.D.;
#=GF RL Proc. Natl. Acad. Sci. U.S.A. 100:11529-11534(2003).
#=GF RC Function description for P38957
#=GF RN [2]
#=GF RM 15654096
#=GF RT "A genetic screen for top3 suppressors in Saccharomyces
#=GF RT cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes
#=GF RT involved in error-free DNA repair.";
#=GF RA Shor E., Weinstein J., Rothstein R.;
#=GF RL Genetics 169:1275-1289(2005).
#=GF RC Function description for P38957
#=GF RN [3]
#=GF RM 17671161
#=GF RT "Shu proteins promote the formation of homologous recombination
#=GF RT intermediates that are processed by Sgs1-Rmi1-Top3.";
#=GF RA Mankouri H.W., Ngo H.P., Hickson I.D.;
#=GF RL Mol. Biol. Cell 18:4062-4073(2007).
#=GF RC Function description for P38957
#=GF RN [4]
#=GF RM 19496932
#=GF RT "The yeast Shu complex couples error-free post-replication
#=GF RT repair to homologous recombination.";
#=GF RA Ball L.G., Zhang K., Cobb J.A., Boone C., Xiao W.;
#=GF RL Mol. Microbiol. 73:89-102(2009).
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This entry represents the SHU2 proteins found in fungi. SHU2 is
#=GF CC a component of the Shu complex, which includes CSM2, PSY3, SHU1
#=GF CC and SHU2 [1]. The complex plays a role in RAD51/RAD54- dependent
#=GF CC homologous recombination repair to repair MMS-induced lesions
#=GF CC during S-phase [1,2,3]. SHU2 is required for error-free repair
#=GF CC of spontaneous and induced DNA lesions to protect the genome
#=GF CC from mutation [1]. The protein is localised to the nucleus and
#=GF CC is found at sites of double-strand breaks [1]. SHU2 promotes the
#=GF CC formation of homologous recombination intermediates that are
#=GF CC processed by Sgs1-Rmi1-Top3 [2]. The Shu complex couples error-
#=GF CC free post-replication repair to homologous recombination [3].
#=GF SQ 51
#=GS A0A0C7N558_9SACH/106-305 AC A0A0C7N558.1
#=GS A0A8H7BB83_9PLEO/37-264 AC A0A8H7BB83.1
#=GS A0A1E5R754_HANUV/11-90 AC A0A1E5R754.1
#=GS J5RHS2_SACK1/9-74 AC J5RHS2.1
#=GS G8YKW8_PICSO/152-370 AC G8YKW8.1
#=GS A0A1E5RVW3_9ASCO/59-217 AC A0A1E5RVW3.1
#=GS SHU2_CANGA/11-246 AC Q6FM84.1
#=GS SHU2_VANPO/10-243 AC A7TGA7.1
#=GS SHU2_EREGS/9-65 AC Q74ZQ8.1
#=GS A0A376B925_9ASCO/1-91 AC A0A376B925.1
#=GS A0A8J5UGI8_9ASCO/111-234 AC A0A8J5UGI8.1
#=GS B6QI10_TALMQ/86-219 AC B6QI10.1
#=GS SHU2_KLULA/12-246 AC B4UNA2.1
#=GS I6NDZ1_ERECY/11-255 AC I6NDZ1.1
#=GS G0W3X8_NAUDC/12-297 AC G0W3X8.1
#=GS R0IUY4_EXST2/120-307 AC R0IUY4.1
#=GS A0A1G4MKA0_LACFM/11-245 AC A0A1G4MKA0.1
#=GS A0A1E3PP12_9ASCO/151-268 AC A0A1E3PP12.1
#=GS A0A7H9HY72_9SACH/10-235 AC A0A7H9HY72.1
#=GS J7S6T0_HUIN7/60-211 AC J7S6T0.1
#=GS J8LQ97_SACAR/62-218 AC J8LQ97.1
#=GS A0A9P0W0R2_9ASCO/141-269 AC A0A9P0W0R2.1
#=GS G8BRZ5_TETPH/11-260 AC G8BRZ5.1
#=GS A0A0D2IS06_9EURO/54-268 AC A0A0D2IS06.1
#=GS A0A1G4INQ6_9SACH/10-260 AC A0A1G4INQ6.1
#=GS G0VA18_NAUCA/11-260 AC G0VA18.1
#=GS A0A1G4KHP6_9SACH/11-243 AC A0A1G4KHP6.1
#=GS J7S6T0_HUIN7/8-76 AC J7S6T0.1
#=GS A0A1E5RVW3_9ASCO/11-70 AC A0A1E5RVW3.1
#=GS SHU2_YEAST/61-218 AC P38957.1
#=GS I2GY33_HENB6/10-69 AC I2GY33.1
#=GS I2GY33_HENB6/58-210 AC I2GY33.1
#=GS SHU2_YEAST/9-74 AC P38957.1
#=GS Q6BYP3_DEBHA/212-380 AC Q6BYP3.2
#=GS A0A061HH11_BLUGR/45-247 AC A0A061HH11.1
#=GS A0A376B925_9ASCO/65-224 AC A0A376B925.1
#=GS A0A9X9MN29_BLUGR/45-247 AC A0A9X9MN29.1
#=GS G8YNA0_PICSO/94-370 AC G8YNA0.1
#=GS J8LQ97_SACAR/9-79 AC J8LQ97.1
#=GS G8ZLJ9_TORDE/10-246 AC G8ZLJ9.1
#=GS SHU2_EREGS/57-197 AC Q74ZQ8.1
#=GS H2AS96_KAZAF/9-249 AC H2AS96.1
#=GS A0A7H9AXX2_ZYGMR/10-249 AC A0A7H9AXX2.1
#=GS J5RHS2_SACK1/62-218 AC J5RHS2.1
#=GS A0A367XWJ2_9ASCO/105-182 AC A0A367XWJ2.1
#=GS A0AAI9SYY6_9ASCO/81-245 AC A0AAI9SYY6.1
#=GS SHU2_ZYGRC/66-217 AC C5DRT0.1
#=GS A0A0C7N558_9SACH/10-120 AC A0A0C7N558.1
#=GS A0A1X7R8A9_9SACH/8-261 AC A0A1X7R8A9.1
#=GS SHU2_LACTC/10-244 AC C5E2S6.1
#=GS SHU2_ZYGRC/14-76 AC C5DRT0.1
A0A0C7N558_9SACH/106-305 ......................................................................................................................................pettktraqqa----------..-...--.....---------------....---------------------------...........TGERKLDTDRDLNGv...aNTGISRETSQKKC..............NVSSGIQGKNM............VDALYDDDPAq..rIVNRLVIKQ.NNDQ...............TPPVCVDLNRWFCSCEEF.N.TQFLQN..IIKPTNTdp....pdqTTLYSRAVQDLnTDHVPQRS......................DR.FAQLPHNPAdHVQHYFRH...........EM...AMCPHLLAFAILLQTS...........ARVLSYF.TDTNMTVYLITVHNLDEWLNLH.....................
A0A8H7BB83_9PLEO/37-264 .........................................................................................................................aktninplnnlsdatrkhllsfqv----------..-...--.....-----------VFPT....E-FVPALDLLDRRLVTRFHIRNEEQMA...........ELKTVVDAGDQQQD.....VHMMQDTTVEMTD..............KDKTNDLNNNN............NNTIYYVRSA...qQQRSSRFAT.SYDT...............TTYYQVRLRAWNCSCPAF.AfSAFPATtvTTRHA-Ene....etaAAVHTPLHNNP.TTHQELDNs....................kDS.NNSDDDNAD.NKWIF--Ggisl..vgketMP...PVCKHLLACVF-----...........-------.----------------------verckglfggfve........
A0A1E5R754_HANUV/11-90 ................................................................................................................................................g-RIYSKLIKD..D...YK....gINEEITTFLILIGNNdqfiDLYIMAISLLDSKNMFIYNYKNISQKIi.........yK-------------.....-------------..............-----------............----------....---------.----...............------------------.-.------..-------.........-----------.--------......................--.---------.--------...........--...----------------...........-------.----------------------dileqetqaksiddfdk....
J5RHS2_SACK1/9-74 .................................................................................................................................................SKLFAKLVDQndD...TK.....LDDVIASFLYYMFPR....ELFIRAISLLESSDMFIYILDKFHEEE...........NKVS----------.....-------------..............-----------............----------....---------.----...............------------------.-.------..-------.........-----------.--------......................--.---------.--------...........--...----------------...........-------.----------------------rslvd................
G8YKW8_PICSO/152-370 ............................................................................................................................lfkqeetspedyiitvrvtqq----------..-...--.....---------------....---------------------------...........-----RRTEMDHRR.....KVSLKKAAKIRKEliqlel..eeilhrAKVSQREMQQS............IGSFQHMHEI....DKRRSELES.ELNSgf..........slsQVSHVVDLKTWYCTCTEY.Q.MCYTRS..FTSDHTE.........EQELDPASHSL.PTATQVSPytkglkmvaanelikgepncvsK-.---------.----FFTGmknknttkhlqQL...PICCHLLAVVLVSANM...........N------.----------------------qhsklhsvsfhtniktv....
A0A1E5RVW3_9ASCO/59-217 ...........................................................................................................................................tpvpll----------..-...--.....---------------....---------------------------...........--------------.....-------------..............-ETNANQQETL............LSSFYKNQNDs..qYLKRIIIKE.-NNE...............KDIVFVDLDSWYCGCEEH.N.RKYRDS..MDDLSSLvek...kqeLNTSQNKTMYF.SQPPQEPE......................DF.FAKIPAS--.--KQYDSS...........CK...IMCPHLLAAAILLQSS...........MAVFQHF.LTKKETCYIIKVESMDEWLRLQ.....................
SHU2_CANGA/11-246 .................................................................................................................................................SEIFSTLVKD..D...G-.....VDDMVASFLYYMFPR....ELFIRGLSLLESSDMFIYVFDAMKGES...........-SESEVNTDVDTSV.....NLSSKENIATSTTatq........inaKDNSVDVTKNY............LNKLYEDDDL....LQYRLIVKS.SSSDg.............iETPVYVDLHNWLCSCEEY.T.EIMREC..LLADK--.........-DLVQEFVQLI.DDFSCFRD......................DT.FGQIEAHSL.SLQKYVNT...........KK...LLCPHLLAYSIILLSS...........PKVLRHY.TVEKPGVIVIPITSIDEWLKLH.....................
SHU2_VANPO/10-243 .................................................................................................................................................SQFFSKLIND..N...NE.....MDDTMTSFLYYLFPR....ELFIRALSLLDSGDMFIYVLENGNISS...........SSMNLVPTVCDSDEs...rSPSSSGNSNNEAS..............NESNTIDSNSI............VEELYDIDTE....LQNRLIVKT.HEKD...............SPPIYVDLKTWFCSCDEF.N.SYFNLE..LQKNQSI.........-PIQDTLIRNI.DDIQEFSE......................DK.FAQIDAHSL.SKQKYVCH...........EK...LMCPHLLAYSILLASS...........TKTLRYF.TLVNQTVLLIRISNMDEWLKLH.....................
SHU2_EREGS/9-65 .................................................................................................................................................SKLLRNLVTE..D...NV.....LNEVVVSFLYQLFPR....DLFVRAFSLLESADMFIYVWMPTPKEA...........--------------.....-------------..............-----------............----------....---------.----...............------------------.-.------..-------.........-----------.--------......................--.---------.--------...........--...----------------...........-------.----------------------de...................
A0A376B925_9ASCO/1-91 .........................................................................................................................................mvskdnsr---------N..E...LK.....LNENILGFCYNLFEP....DLFIKAISILESNNLFIYILNLDNKND...........EEINKSLTLCNVNK.....EK-----------..............-----------............----------....---------.----...............------------------.-.------..-------.........-----------.--------......................--.---------.--------...........--...----------------...........-------.----------------------vmfriiikedsddcnqndsdg
A0A8J5UGI8_9ASCO/111-234 ......................................................................................iycclsmgielndyfndplkftttqfkititsrstvnmeeklllklgykklhgrlvpss----------..-...--.....---------------....---------------------------...........--------------.....-------------..............-----------............------DNNT....STNEIIISS.KSLG...............-DYNSVDLYNWYCDCDEY.Q.QSYTDD..MKPVKINg.......dSNLIECL----.--------......................--.---------.--------...........--...----------------...........-------.----------------------lsqsksii.............
B6QI10_TALMQ/86-219 .............................................................................................................................................hdnn----------..-...--.....---------------....---------------------------...........--------------.....-------------..............---------NL............NNNIDNDNDD....TLIS-IVQS.TSNHdrd........agggGKVYHVHLKTWNCSCPAF.VmNCFPPS..TSDDIN-.........--GDSDMIDDV.IGGQDFEE......................DAwFGGTIRNR-.-ESSYDDR...........SV...PICKHMLACVLVAK--...........-------.----------------------cpnlfgrkcltyevnn.....
SHU2_KLULA/12-246 .................................................................................................................................................SQLLSELVDG..R...GR....tLNDTTVAFLYQLFPN....DLFVKAFSLLETHNLFLYVWDSIDDVAl.........nDGVQCSDAEIDETSnsvagSRLPTEGHQCHSK..............RNSNDNDISRL............ANMLYDLETRs..kTLHRIIVQS.VDEEv.............sKKPIYVDVTAWFCSCNEY.T.KCFSGM..LHNNGDE.........--GYQGM---F.ETYGNETD......................DN.FAKVNSHTH.-----VNS...........SK...VICQHLLAAAILLQTS...........LKVLKYF.TSVKQSVSLFSINNKDDWLKLH.....................
I6NDZ1_ERECY/11-255 .................................................................................................................................................SKLLCNLVTD..A...YS.....LNEVVVSFLYQLFPR....DLFVRAFSLLESGNMFIYIWNDEKYTQliqatevaenvHGTKATDVGIGDPN....rQYRSCGNAADYPE..............EEPEGSHSEQLg.........lqIAAFYENRQQ....LLYRLIIKE.EHED...............DSPIYVDLDHWFCSCDEF.N.GLLHDA..ASSPTF-.........-HSKEELTSS-.YTENTDNQ......................DS.FARLGTLDL.T-GIFIKH...........EK...LMCSHLLAFAILLQTH...........EKILRYFsKGPSTQIFMINICSTDEWLKLH.....................
G0W3X8_NAUDC/12-297 .........................................................................................................................selfknliipreqstkkpsenktv--------RE..D...GDedamiINDNIITFLYYLFPR....ELFIKALSLIESNDMFIYVLLPNHIDPsmen...nkdkNNTYITKTFDDKADk..dnMASRSKTIDNNDAddtv.....ektksNEPTRTSIDSIk..........lIDMLYDEDNDdddsLIYELIIKS.SNDR...............IPPITTTLKNWNCSCVEF.T.EHFRKGmmMKNNIDE........eMKLIDRFIKII.DDPTKFSN......................DI.FAKIDKFSL.SKQYYFDL...........IKnkgIICPHLLAYSILLKSS...........KQVLKYF.ILNKADVILIPITNMDEWLKLH.....................
R0IUY4_EXST2/120-307 ....................................................................................................................................eheqheeaihmrn----------..-...--.....---------------....---------------------AHDASK...........HHNTRTPSSSNDDT.....TVQEPNTTTTTTT..............TPPPIPQIPPI............HNTYYVRSAQ....HRSSRHAPA.SYDA...............TTSYQVRLAAWNCSCPAF.AfAAFPAG..IDDDEVD.........DTYHYPENEQN.HAYEQEYEy....................eEQ.EQQHPACSF.GGMTLGDH...........MP...PVCKHLLAC-VLAESC...........PTLFGAF.VQEKH-----------------vtlaea...............
A0A1G4MKA0_LACFM/11-245 .................................................................................................................................................SQLFSQLIDE..E...DE.....MNETVVSFLYHLFPN....ELFVRGISVLESGNMFIYVLEKDGKEL...........HSNSSSSTDNDAPS.....-VSTAEASEPSSTsl.........ndiFQSSHTKENSL............VEKLYTEPHS....LTYRLIVKQ.EELK...............SPPIYVDLPHWFCSCDEF.N.ELFKQE..MLENEE-.........PSLYSQAVFEL.IDESEHLE......................DK.FGLLAPRSG.H-QRFFRH...........EL...VMCPHLLAFGLILETR...........PAMLRYF.IEKRSQVFLITIQNVDEWLKLH.....................
A0A1E3PP12_9ASCO/151-268 ...........................................................................................................................egeleqqiwrvgnklskgacsr----------..-...--.....---------------....---------------------------...........--------------.....-------------..............-----------............----------....---------.KASD...............EKSYRVDLAQWNCGCTEFlC.AAFARQ..TNSGNSDs......dtDEDRERKGEEI.KSENKEKR......................DV.YSIGFGG-T.GYIRKLRH...........DRr.pAVCRHIMAC-------...........-------.----------------------ylgera...............
A0A7H9HY72_9SACH/10-235 .................................................................................................................................................SRLFAQLIGK..D...GH.....MNDTIASFLYYLFPR....ELFVRALSLIESNDMFIYILDTTRCDR...........-NRSDTSTDADSP-.....SKPSSKRTDTVPT..............QTSTVIETHPL............VGMAYENGPD....YLHRLIVKH.---A...............NQPIFVDLQNWFCSCDEY.T.QLFAQE..TTPHPND.........--CVSLLVSDI.DDLQDFSD......................DK.FAQLDAHSL.CKQRYFRH...........DK...LICAHLLAYSILLRSS...........KNILSYF.TTTRQLVPMIKVNNMDEWLKLH.....................
J7S6T0_HUIN7/60-211 ...............................................................................................................................................sa----------..-...--.....---------------....---------------------------...........--------------.....-------------..............----EATSETL............LSKFINTDFLd.ldIMYRLIVKSgENDS...............DVPISVDLAQWFCSCDDF.S.KLFTDV..GNENPEG.........-SIQDVLLKEI.DDFDQFSD......................DK.FAQFDSHSL.NTQRYLQF...........EK...VMCPHLLAFAILLLAD...........GKNLRHF.AALKRSVVLIPVGSIDEWLKLH.....................
J8LQ97_SACAR/62-218 .............................................................................................................................................hknk----------..-...--.....---------------....---------------------------...........--------------.....-------------..............DDKSASLVDVV............IDEFYKDSSVs..pLEYRLIVKD.NNEG...............APPILVDIAHWFCTCEEY.S.KNFYEA..VERTDEK.........EELCDVLINEI.DDHLQFSD......................DK.FAQLDPRSL.SKQWYFRF...........DK...TCCSHLLAFSILLKSS...........INVLKFF.TVSSNKVFLISIDNIDEWLNLH.....................
A0A9P0W0R2_9ASCO/141-269 ...............................................................................................................epidavrhrvlinelarleagdqeasppdfgiyq----------..-...--.....---------------....---------------------------...........--------------.....-------------..............-----------............----------....---------.----...............--VFSVDLKSWYCNCDEY.Q.DQMADN..SENHPEAyr....kekGEFSLKSMEEI.ISQSRGAS......................GL.LLDILTSSE.IPTR-HKS...........PL...PLCSHLLAVIIC----...........-------.----------------------synrkiely............
G8BRZ5_TETPH/11-260 .................................................................................................................................................SKLFGNLINS..R...WK.....LDDTMISFLYYLFPR....DLFVRALSLLDSGDMFIYLLESGPEEQv.........cEEAAVVHTGEDGTTh..eqERSDDNGLENQQTre.........tldSSNYQTFLEEF............SRKLYDPGQS....IPKRLIVKS.NEDT...............DVPIYVDLGTWICSCGEY.T.ERFQEA..MTAGPSDass..qetnSKLSSILLTIK.DDSSKFSD......................DK.FAQIDAHSL.SSQYYIDH...........SK...LICPHLLAYSILLSSS...........QRTFRYF.AIRNPTVLLIKITNLDEWLRLH.....................
A0A0D2IS06_9EURO/54-268 ............................................................................................................................hsllynlspadaeharslflt----------..-...--.....--------LHVLFPH....EL-LPALDLLDRRLV--TRLTTQNLPP...........RSPGRRGAARDEDA.....DVDTAEKCEMLN-..............KELKVESRSDM............CEVYYIHSHPskvtTLARYHARN.ANPG...............ATFYEVHLDSWNCSCPAF.S.VSAFQA..LNMHYND........eGEIASKAS-QV.DHMHEPTTle.................kesWS.FGGVATN--.-----VHS...........ST...PSCKHILA-AVLVKAA...........PKLFNH-.----------------------gvretvvs.............
A0A1G4INQ6_9SACH/10-260 .................................................................................................................................................SQLLSQLLDE..K...GE.....LNDTITSFLYHLFPE....ELFVRAMSLLDSNDMFIYVYDKLQTES...........KHIKSISTEPDEPEarealSGTSNEMLKTSEAa...........esRPDAGANSKDI............AHLLYEGREA....PLNRLIVKP.ETPE...............SPPICVDLDHWFCSCEEY.N.CQFRSN..LLNVPEQpagpvdleeSSLYSRAIVEHeLKSQAPHS......................DR.FAQVKSLHL.QFQRYFRH...........EL...AMCPHLLAFAILLQTS...........SAILMYF.THTNATVYLITVQNLDEWLKLH.....................
G0VA18_NAUCA/11-260 .................................................................................................................................................SQLFSQLIKP..A...TSgdggvMDDTMASFLYYLFPR....ELFIRALSLLESNDMFIYTFQPDSSLP..........lKESSTTKTFDDKDA....vTKTSSDLTSSSKTdpdner.dsneaegKKEKEKEIEEL............VNDVYNEEDQ....FLHRLIVKP.ENTH...............SPPISVDLLNWFCSCSEF.N.ELFHEE..LKKGE--.........-ELSNCLIKEI.DDMSEFSN......................DK.FSQLDAHSL.SRQKYFKF...........DK...CLCHHLLAYSIILRSS...........PDILRYF.TLKNCSVFHLRIDNLDEWLKLH.....................
A0A1G4KHP6_9SACH/11-243 .................................................................................................................................................SQLLSGIIET..NegvDQ.....LNEVVVSFLYHLFPK....ELFVRALSLLESSNMFIYVLENKTCDE...........HGSKQVDNTNGSRVs...aSLLISEANLVPSG..............NDSSRTEQRHL............WELLYETE-Q....LQHKLIVEN.EDSV..............gGTPVVTDLDRWFCSCSEY.I.TLFGDE..LQQDDDE.........RPLACKLVQEI.-DKTEGAH......................DK.FARIKQQ--.--QRYFRH...........DK...IMCPHLLAFSILLQTE...........PKTLRYF.TGTRQTVYLIRVQNIDEWLRLH.....................
J7S6T0_HUIN7/8-76 ................................................................................................................................................i-DLLSRFIGDgkD...GE....eLDGNVASFLYYLFPR....ELFVRALSLLESNDMFIYCYDSAEATS...........E-------------.....-------------..............-----------............----------....---------.----...............------------------.-.------..-------.........-----------.--------......................--.---------.--------...........--...----------------...........-------.----------------------tllskfintd...........
A0A1E5RVW3_9ASCO/11-70 .................................................................................................................................................SEILSQLVNE..E...NE.....LNQDILAFCFNLFDS....ETFIKALSILESRNLFLYLFTPVPLL-...........--------------.....-------------..............-----------............----------....---------.----...............------------------.-.------..-------.........-----------.--------......................--.---------.--------...........--...----------------...........-------.----------------------etnanq...............
SHU2_YEAST/61-218 ...........................................................................................................................................vhnkeg----------..-...--.....---------------....---------------------------...........--------------.....-------------..............-NEHTSLIDVL............VDEFYKGSSNs..lLEYRLIVKD.TNDG...............APPILVDIAHWFCSCEEF.C.KYFHEA..LEKTDEK.........EELHDVLINEV.DDHLQFSD......................DR.FAQLDPHSL.SKQWYFKF...........DK...VCCSHLLAFSILLRSS...........INVLKFF.TVNSNKVFVIAIDNIDEWLNLH.....................
I2GY33_HENB6/10-69 .................................................................................................................................................SELFSELVND..E...GQ.....LDDAKASFLYYMFPQ....EMFIRALSLLESGEIFIYIYPCSTS--...........--------------.....-------------..............-----------............----------....---------.----...............------------------.-.------..-------.........-----------.--------......................--.---------.--------...........--...----------------...........-------.----------------------tdleslv..............
I2GY33_HENB6/58-210 ..........................................................................................................................................pcststd----------..-...--.....---------------....---------------------------...........--------------.....-------------..............---LESLVNTI............VQTVYNDHND...gKLIKVVVQT.NDDR...............--TIFTDIEHWFCSCQEY.S.EKFSQI..ITSDPET.........-PLQVLLLKEI.DNVEDFSS......................DK.FAQLEANSL.SKQRYFNH...........SK...VICPHLLACSILLKSS...........SRILHFF.TVTKGSVLVFPINDIDEWLRLH.....................
SHU2_YEAST/9-74 .................................................................................................................................................SKLFAKLVNTndD...TK.....LDDTIASFLYYMFPR....ELFIRAISLLESSDMFIYILDRVHNKE...........GN------------.....-------------..............-----------............----------....---------.----...............------------------.-.------..-------.........-----------.--------......................--.---------.--------...........--...----------------...........-------.----------------------ehtslid..............
Q6BYP3_DEBHA/212-380 ..............................................................................................................................lttipkstsilniptntsk----------..-...--.....---------------....---------------------------...........--------------.....-------------..............-----------............PTTMFSAN--....SVERTRLQK.ELDAav..........atkRESYVVDLKSWYCSCDEF.Q.ASYVPQ..TTPDTSDn.......dSDTHCPISPY-.DTLSTPAGlym...............mdtdDL.IAKCHDNPI.--TRYFRSlsphnqtrhlsKL...PICCHLIALSIAATNS...........PHTHRYFtILSSDNV---------------wsml.................
A0A061HH11_BLUGR/45-247 ............................................................................................................................................rqail----------..-...--.....------ITLHALFPP....PMLLQALDLLDRGLVTRIVLTSHHVSR...........EQDDPHALQQPAIS....nTNLSADSPNVMHHnp.........aleIKVRSGSIGGM............YQVCSTQPKK...rAPKRSSYRN.TSSS..............aEKYYTVYLTAWNCSCADF.T.FSLFPA..LLVDSVS.........SKNSKNDIEDA.KVDNESVE......................WE.FGGVRRKNA.T------E...........TV...PICKHLIACLI-----...........-------.----------------------gerwgkllgsyvkerq.....
A0A376B925_9ASCO/65-224 ...........................................................................................................................................nvnkek----------..-...--.....---------------....---------------------------...........--------------.....-------------..............-----------............----------....VMFRIIIKE.DSDDcnqndsdgnlknkknTSIVFTDLPNWYCSCNEF.N.GKFQQK..LNTVNLK.........KDLVVIYNHHK.DRLNEHGK......................DY.FGKFQYSSH.-KDKYT-S...........GL...LMCPHLLASAMLLQNSdekigdslleeNRVLRYF.TKIKQSCYIIQVTNIDEWLRLQ.....................
A0A9X9MN29_BLUGR/45-247 ............................................................................................................................................rqail----------..-...--.....------ITLHALFPP....PMLLQALDLLDRGLVTRIVLTSHHVSR...........EQDDPHALQQPAIS....nTNLSADSPNVMHHnp.........aleIKVRSGSIGGM............YQVCSTQPKK...rAPKRSSYRN.TSSS..............aEKYYTVYLTAWNCSCADF.T.FSLFPA..LLVDSVS.........SKNSKNDIEDA.KVDNESVE......................WE.FGGVRRKNA.T------E...........TV...PICKHLIACLI-----...........-------.----------------------gerwgkllgsyvkerq.....
G8YNA0_PICSO/94-370 dtekslglsllfgdiytralavlsspsnvdvmifsrlgqepedlqelgakylagefdgrfkqeetspedhiitvrvtqqcrtevdhrrkvslkkaakirkeliqleleeilhrakisqmgsyqstsghqhmheiekrrseleskl----------..-...--.....---------------....---------------------------...........--------------.....-------------..............-----------............----------....---------.--NSgf..........sicEVSHVVDLKTWYCTCTEY.Q.MCYTRS..FASDNTE.........EQTSGPASPNL.PTITQVSPytkglrmvaaneliegepncvsKF.FTGMKDKNT.TK--H-LS...........SL...PICCHLLAVVLVSSNM...........-------.----------------------nqdsrlhsvsfhtniktv...
J8LQ97_SACAR/9-79 .................................................................................................................................................SKLFAKLVNSndD...TK.....LDDTIASFLYYMFPR....ELFIRAISLLESSDMFIYILDKVHKNKd.........dKSASLVD-------.....-------------..............-----------............----------....---------.----...............------------------.-.------..-------.........-----------.--------......................--.---------.--------...........--...----------------...........-------.----------------------vvide................
G8ZLJ9_TORDE/10-246 .................................................................................................................................................TKLFSQLIDK..D...GQ.....MDDTIASFLYYLFPR....ELFIRAVSLIESCDMFIYVLDPDNCHLd.........sRITTSVSTDVDSPT.....SSNSVGPITPPVAd...........knPTNKSQETDTL............VSIVYDSESD....TLHRLIVKT.DHGG...............NPPIYVDLQNWFCSCDEY.S.DLFASE..TDKIADE.........-SYIDHLSNEV.TDLHEFSD......................DR.FAQLDAHSL.SKQRYFLH...........DK...VCCAHLIAYSLLLRTS...........KRVLHYF.ATEKQQVPMIRVTSMDEWLKLH.....................
SHU2_EREGS/57-197 .............................................................................................................................................mptp----------..-...--.....---------------....---------------------------...........--------------.....-------------..............-----KEADEL............LESLYNGT--....PLYRPIVRP.RGPD...............DRPVCVDLDHWFCSCTEF.A.ATCRPH..LVGDT--.........-PLSDALFRP-.-TEAADPD......................DC.FGMLAGLQH.LR---ADP...........EK...LMCEHLFAFAILLQTD...........LRVLRHFsTGPGAQVFVLGITSIDEWLKLH.....................
H2AS96_KAZAF/9-249 .................................................................................................................................................SKLFSKLLKE..H...NE.....IDDTVSSFLYYMFPR....DLFIRALSLIESNNMFIYALAAECCQV...........--SALTTTFHDTPV.....SSTISKSVTSEITeidv......nipqMSSPISQVNKL............IEKFMQDDID....LSYRLIVRP.ENTQ...............SSPLYVDLDNWTCSCTEF.S.ELFQKE..LETSRNSa.......nTDLKDLLIREI.DDMNDFSE......................DK.FAQLDSHSL.SKQRYFKW...........ER...ITCCHLLAYSIVLKSS...........PKLLRYF.IVEKTNVLLIPINNIDEWLKLH.....................
A0A7H9AXX2_ZYGMR/10-249 .................................................................................................................................................SKLFSRLINK..N...GQ.....MDDTIASFLYYMFPK....EMFVRALSLIESSNMFIYAFDIQEVNSr........amEPSDSASTNPDESV.....RQNSSESTSFVPAn...........kpSSPHSATTHVL............VAPIYENDSE....LLYRLIVKA.DSDT...............DPSVYVDLTNWFCSCEEF.A.NGFLEH..GLNGTSK........eDDIAQRLTREV.TELQDFSD......................DR.FAQLDAHSL.SKQRYFHH...........DK...VMCPHLLAFSILLRSS...........PSVLQYF.AVNKGQVLLIPITNMDEWLKLH.....................
J5RHS2_SACK1/62-218 .............................................................................................................................................heee----------..-...--.....---------------....---------------------------...........--------------.....-------------..............NKVSRSLVDML............IDKFYTDSLDs..pLEYRLIVKD.TNDG...............APPILVDIAHWFCSCEEY.C.KHFHET..LEKTDEK.........EELHDLLINEV.DDHLQFSD......................DK.FAQLDPHSL.CKQWYFKF...........DK...ICCSHLLAFSILLKSS...........ITVLRFF.TDSSNKVFVISIDDIDEWLNLH.....................
A0A367XWJ2_9ASCO/105-182 ........................................................................................................................aqllaklglcwrndtlikgnlhfih----------..-...--.....---------------....---------------------------...........--------------.....-------------..............-----------............----------....---------.-QER...............GSPVHVDLANWFCECQEY.Q.TKYFDG..MELINVT........gNTLVHRLLQEL.K-------......................--.---------.--------...........--...----------------...........-------.----------------------skils................
A0AAI9SYY6_9ASCO/81-245 ......................................................................................................................wvfameiegdvdfqkyttnkqqqqqqe----------..-...--.....---------------....---------------------------...........--------------.....------------Slhi.......ikliAKKEKRNIHALlaklgyewkdgkFSPLLKTDKK....KQPSLGIIE.EKEE...............EEEYHVDLDNWYCDCREF.T.QKLNDN..S-----Q.........-LLCKSNLKVI.SFNEKSQN......................NL.LWQILFKSP.C-NQFLPI...........--...SICRHLLAIFIVIYNY...........-------.----------------------knyek................
SHU2_ZYGRC/66-217 ...........................................................................................................................................vndknn----------..-...--.....---------------....---------------------------...........--------------.....-------------..............QPLKFLEVSDL............VNSIYDDS--....ELHRLIVKP.-SDE...............DVPTYVDLNNWMCSCQEY.T.DLMLER..LNQMEAG.........-SLASSLLKDI.DDSQRFQE......................DR.FAQLDAHSL.SMQRYVHC...........EK...LNCPHLLAYSILLRSS...........TRTLQHF.-LEKGQILLIQINNMDEWLKLH.....................
A0A0C7N558_9SACH/10-120 .................................................................................................................................................SQLLSHLLTE..E...GD.....LNDGVVSFLYHLFPG....DLFVRAMSLLDSRDMFIYLFDDSRNAC...........KHSESTETEPDRDF.....VASSSPSRGSENKl...........vkKSLEQDQKNHI............PET-------....---------.----...............------------------.-.------..-------.........-----------.--------......................--.---------.--------...........--...----------------...........-------.----------------------tktraqqatger.........
A0A1X7R8A9_9SACH/8-261 .................................................................................................................................................SELFSRLLDN..E...GN.....LNNSMLTFLYYMFPR....DLFIRALSLLESNDMLIYILEEGLVNDns.......tgKEAERTVTLADKPT.....SERSTNTLEDKQDtdsikkgnnssdtdTHERIEDMDKL............LKDIYNDDDY...qLLYRLIVKS.D--N...............ESPIYVDLKDWTCSCTEY.C.ELFSKE..IHSAEESnt.....nnSTIQDIMINEI.DDIEEFKE......................DR.VGQLDAYSF.SKQRYFKI...........DK...IMCSHLLAYSILLRSS...........LKNLNYF.VQKKSNVLLIRISNIDEWLKLH.....................
SHU2_LACTC/10-244 .................................................................................................................................................SQLLAQLLDK..D...GE.....LNETTVSFLYHLFPS....DFFVRAMSLIDSNNMFIYVFERDETSA...........ALTTSVGTEPDEV-.....-ETTTETLRTSPSppv.......aseqELGNAVQSSAL............INTLYEKPQS....VLHRLIVKQ.EGPQ...............SPPVCVDLRHWFCSCDEY.N.TLFEER..MLTDEE-.........PSLYSKATTEL.-RAGASIT......................DS.FASMPPKGA.S-RRYFRH...........DI...IMCPHLLAFAILLQTT...........PELLTYF.THKAATVYLITIQNLDEWLKLH.....................
SHU2_ZYGRC/14-76 .................................................................................................................................................SELFSQLVNK..D...GQ.....MNDTVASFLYYMFPR....ELFIRALSLIESCNMFIYVLVPSGVND...........KNNQ----------.....-------------..............-----------............----------....---------.----...............------------------.-.------..-------.........-----------.--------......................--.---------.--------...........--...----------------...........-------.----------------------plkf.................
#=GC seq_cons ...................................................................................................................................................................................hh.........l.uhsll-pt.h..h.h........................................................................t.h.............p.h.p.t.........c.hlpt.pttt...............t.shhVDLtpWhCSCpEa.s.tha.pt..h.ts..t..........ph.p.hhpph..s.tp.tp......................-..auth..pt......hhp............ph....hC.HLLAhsllh.s...............................................................
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