#=GF ID   SID
#=GF AC   PF11778.11
#=GF DE   Septation initiation
#=GF AU   Wood V;0000-0001-6330-7526
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Pfam-B_41015 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   25.40 25.30;
#=GF NC   24.10 24.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10805785
#=GF RT   Sid4p is required to localize components of the septation
#=GF RT   initiation pathway to the spindle pole body in fission yeast. 
#=GF RA   Chang L, Gould KL; 
#=GF RL   Proc Natl Acad Sci U S A. 2000;97:5249-5254.
#=GF RN   [2]
#=GF RM   11676915
#=GF RT   S. pombe cdc11p, together with sid4p, provides an anchor for
#=GF RT   septation initiation network proteins on the spindle pole body. 
#=GF RA   Krapp A, Schmidt S, Cano E, Simanis V; 
#=GF RL   Curr Biol. 2001;11:1559-1568.
#=GF RN   [3]
#=GF RM   15062098
#=GF RT   Sid4p-Cdc11p assembles the septation initiation network and its
#=GF RT   regulators at the S. pombe SPB. 
#=GF RA   Morrell JL, Tomlin GC, Rajagopalan S, Venkatram S, Feoktistova
#=GF RA   AS, Tasto JJ, Mehta S, Jennings JL, Link A, Balasubramanian MK,
#=GF RA   Gould KL; 
#=GF RL   Curr Biol. 2004;14:579-584.
#=GF RN   [4]
#=GF RM   11514632
#=GF RT   Cnm67p is a spacer protein of the Saccharomyces cerevisiae
#=GF RT   spindle pole body outer plaque. 
#=GF RA   Schaerer F, Morgan G, Winey M, Philippsen P; 
#=GF RL   Mol Biol Cell. 2001;12:2519-2533.
#=GF DR   INTERPRO; IPR021750;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family is required for activation of the spg1 GTPase
#=GF CC   signalling cascade which leads to the initiation of septation
#=GF CC   and the subsequent termination of mitosis. It may act as a
#=GF CC   scaffold at the spindle pole body to which other components of
#=GF CC   the spg1 signalling cascade attach in pombe [1,2,3]. In
#=GF CC   S.cerevisiae it is both required for the proper formation of the
#=GF CC   spindle pole body outer plaque and may also connect the outer
#=GF CC   plaque to the central plaque embedded in the nuclear envelope
#=GF CC   [4].
#=GF SQ   72
#=GS A0A0C7NC75_9SACH/811-945   AC A0A0C7NC75.1
#=GS A0A0H5C9N7_CYBJN/295-405   AC A0A0H5C9N7.1
#=GS Q6FWH7_CANGA/482-616       AC Q6FWH7.1
#=GS G8YMB1_PICSO/464-565       AC G8YMB1.1
#=GS Q6BY25_DEBHA/514-634       AC Q6BY25.2
#=GS A0A376BBC7_9ASCO/932-1066  AC A0A376BBC7.1
#=GS A0A1E3P9K6_WICAA/293-423   AC A0A1E3P9K6.1
#=GS C5DYS4_ZYGRC/791-925       AC C5DYS4.1
#=GS A0A1D2V9M5_9ASCO/672-815   AC A0A1D2V9M5.1
#=GS A0A5E8BR95_9ASCO/727-850   AC A0A5E8BR95.1
#=GS A0A0E9NH29_SAICN/757-847   AC A0A0E9NH29.1
#=GS A0A170QZ96_9ASCO/449-556   AC A0A170QZ96.1
#=GS A0A0W4ZW75_PNEJ7/625-736   AC A0A0W4ZW75.1
#=GS A0A1E3NR40_9ASCO/461-547   AC A0A1E3NR40.1
#=GS A5DL82_PICGU/281-380       AC A5DL82.2
#=GS A0A1E5RNV5_9ASCO/582-709   AC A0A1E5RNV5.1
#=GS J7S882_KAZNA/397-527       AC J7S882.1
#=GS C4Y1Z8_CLAL4/410-495       AC C4Y1Z8.1
#=GS A3LQW9_PICST/482-602       AC A3LQW9.2
#=GS G8C1Y1_TETPH/944-1078      AC G8C1Y1.1
#=GS A0A1E4TSS9_PACTA/475-608   AC A0A1E4TSS9.1
#=GS A0A1S7HNH7_9SACH/810-944   AC A0A1S7HNH7.1
#=GS G0WD36_NAUDC/394-528       AC G0WD36.1
#=GS A0A2U9RAK6_PICKU/221-342   AC A0A2U9RAK6.1
#=GS A0A1Y2F6R8_PROLT/690-787   AC A0A1Y2F6R8.1
#=GS A0A2V1AUI7_9ASCO/301-407   AC A0A2V1AUI7.1
#=GS G8ZUK0_TORDC/799-933       AC G8ZUK0.1
#=GS ADY3_YEAST/655-789         AC Q07732.2
#=GS J8Q450_SACAR/654-788       AC J8Q450.1
#=GS L0PA02_PNEJ8/464-576       AC L0PA02.1
#=GS A0A1X7R259_9SACH/346-478   AC A0A1X7R259.1
#=GS CNM67_YEAST/442-576        AC P53865.1
#=GS CNM67_YEAST/442-576        DR PDB; 3OA7 A; 442-573;
#=GS A0A1L0DGH0_9ASCO/396-505   AC A0A1L0DGH0.1
#=GS A0A1E3PFI8_9ASCO/877-981   AC A0A1E3PFI8.1
#=GS A0A1E4RGF6_9ASCO/224-339   AC A0A1E4RGF6.1
#=GS A0A4T0WWG4_9ASCO/453-522   AC A0A4T0WWG4.1
#=GS A0A061ASU5_CYBFA/427-556   AC A0A061ASU5.1
#=GS A0A1E4T8Y8_9ASCO/350-451   AC A0A1E4T8Y8.1
#=GS Q6FP18_CANGA/394-528       AC Q6FP18.1
#=GS A0A1S7HAX5_9SACH/810-944   AC A0A1S7HAX5.1
#=GS A0A1G4MJ78_LACFM/748-882   AC A0A1G4MJ78.1
#=GS A0A2P7YCJ4_9ASCO/262-368   AC A0A2P7YCJ4.1
#=GS A0A1G4JID3_9SACH/806-940   AC A0A1G4JID3.1
#=GS C4R740_KOMPG/208-306       AC C4R740.1
#=GS K0KI32_WICCF/329-449       AC K0KI32.1
#=GS B6JY04_SCHJY/552-663       AC B6JY04.1
#=GS G8JUR7_ERECY/711-845       AC G8JUR7.1
#=GS A0A7H9HRS2_9SACH/939-1073  AC A0A7H9HRS2.1
#=GS J7RZC6_KAZNA/453-584       AC J7RZC6.1
#=GS C5DD50_LACTC/805-939       AC C5DD50.1
#=GS I2GXL5_TETBL/391-526       AC I2GXL5.1
#=GS A0A1X7R6P4_9SACH/549-683   AC A0A1X7R6P4.1
#=GS A0A1G4K4A7_9SACH/819-953   AC A0A1G4K4A7.1
#=GS SID4_SCHPO/545-653         AC O60187.1
#=GS H2AW62_KAZAF/432-570       AC H2AW62.1
#=GS A0A7H9B3K1_ZYGMR/777-911   AC A0A7H9B3K1.1
#=GS J4TU05_SACK1/443-577       AC J4TU05.1
#=GS Q6CQ58_KLULA/615-749       AC Q6CQ58.1
#=GS A7TM73_VANPO/820-954       AC A7TM73.1
#=GS J7S4N5_NAUDC/489-623       AC J7S4N5.1
#=GS I2H6G7_TETBL/875-1010      AC I2H6G7.1
#=GS Q75E63_ASHGO/723-857       AC Q75E63.2
#=GS M7PIM2_PNEMU/610-722       AC M7PIM2.1
#=GS G8YBG6_PICSO/465-564       AC G8YBG6.1
#=GS A0A1E4SIU0_9ASCO/494-609   AC A0A1E4SIU0.1
#=GS G0VEX6_NAUCC/465-599       AC G0VEX6.1
#=GS A0A1Q2YK12_9ASCO/465-543   AC A0A1Q2YK12.1
#=GS G3B4B7_CANTC/253-347       AC G3B4B7.1
#=GS A0A1E4TDC1_9ASCO/215-303   AC A0A1E4TDC1.1
#=GS G0VHZ0_NAUCC/351-485       AC G0VHZ0.1
#=GS A0A2H0ZJ75_CANAR/329-416   AC A0A2H0ZJ75.1
#=GS H2APC8_KAZAF/394-526       AC H2APC8.1
A0A0C7NC75_9SACH/811-945              .....................LERIRGNPARAITFQVASQARPD..LN..R..KFYDSLMVDAVNEMDLTDLQNVVKNLILLLEI.P.LPKITKKMPLVAI......YLRYEKSVCLHFANKLHHLMF.G..ETIDIKRYTNIVYGQYIEH.HDISRLNHPLEACLDNLYKAL-s............................................
A0A0H5C9N7_CYBJN/295-405              ....................i-SKYVGDTSEKISPLKFPELSTTdsNG..I..SLYDGLNLCEVDNLTMVESQNLLKNILINLNI.P.FSRVKELVPQLML......RLTHE-EILVDFTRKLHTVLY.D..QGMDITRYLNET-------.----------------------gntg.........................................
Q6FWH7_CANGA/482-616                  .....................LQNLEGNIEESLTEEALKVRFIS..LS..S..ENYNTLDVECIDRQDLVSLRNLLKVLTLTLEI.P.FSKLQTTIPLLAI......RLYHENTSLLSFCNTLHMHLY.G..KPLAIKNYRRWAYADYLKT.CNIHEVQHPIKPILEAMFNKI-a............................................
G8YMB1_PICSO/464-565                  ....................l-KRQLGDSSCSISRDSVSDEF--..--..K..KYYDKLQLSRVDSLTKVELSNLVKNIMLSLLI.S.--DF-EHLPSVSV......KIGKFFKLIASFMDQLHSIVY.D..D------------------.----------------------sstsvkpshylksy...............................
Q6BY25_DEBHA/514-634                  .................lqgq----IGNTNNLITQDSISSDY--..--..K..QFYTKLQLNQVDRLTKIEMSNLIKNLMLSLLI.TdFEHL----PMVSS......KIGKFFKIISLFMDQLHSMVY.D..DS-----------------.----------------------stairpshylknheygmtelqscldgmletls.............
A0A376BBC7_9ASCO/932-1066             .....................LKLLQGDSRKAINLKSVLVSSMG..ID..K..EHYEHLKVDAVNDLDIVELQNLLKNVILTMNI.P.YDYLHQKLVLTSI......YVRLERGYLVKFAHKLHYLLY.N..DKIHIKEFEKMALGEYNVV.KNIDKVNHPLKQCLDRLLVDI-i............................................
A0A1E3P9K6_WICAA/293-423              .....................LSDLIGDTSEEITPERFPSLSFKgsNG..K..SVYDTLELGLVDSLNLSKSHNIIKNILINLLV.P.FSETKETIPKIAK......LLESED-VLCEFSNKLHKLIY.E..QDINISKFQNEQ-------.----------------------ngndhlrqctsqmyknvetlfkel.....................
C5DYS4_ZYGRC/791-925                  ....................v-YKLKGDPSRKITFEVARRSRPD..IN..A..ITYENLMVNKVDSIDMVELQNIVKNLILLLDI.P.FNKLTKKSPLVAI......YLKYERPIFSHFANRLHYQMF.N..EPIDMKRFANEAYGQYTED.HDMRAIKHPLQSCLDNLYQRL-v............................................
A0A1D2V9M5_9ASCO/672-815              ....neskkvsitakkslqtl-----------------QKIISN.rII..S..KFDSFLEFSKIEKLNELQSKDVIKKVCLLMKV.P.FSSLFQAIR-GSL......EICENESILLKFVKNVHTMLYfG..KKMH---------------.----------------------vpsllssipvtveenstkttvsrkkqltlnqtikkinneknafke
A0A5E8BR95_9ASCO/727-850              ..gtarpltsqempdfkpgak-----------------------..IP..S..ALYERLDMPLIDTLGVIEARNFLKNIVMQTGV.N.LHRLENKIAGL-I......SCVCMTDMYIQFVNDLNRALF.K..IPIDAN-------------.----------------------iypfgeerkrtmaqimhevqnlithyknt................
A0A0E9NH29_SAICN/757-847              ...........danepgltre-----------------------..--..D..RIYYRLQLYKVDRLCSNETGNILKNILIQLAT.P.LDELPTSIQRLRN......KLV-EGKRLRRFAEDVHELVY.E..-------------------.----------------------germaegsvekrc................................
A0A170QZ96_9ASCO/449-556              ....klqsqcsqllgrsepin-------------------SHSF..IK..E..KLYNRLELNEVDSMSLIDAQNMIKNIALIFDM.P.VSRFSKWLPMIAK......LLG-EDDVYLNFTQEVHRIIY.S..GQEL---------------.----------------------rkrknqkclqeml................................
A0A0W4ZW75_PNEJ7/625-736              ................hhtkp-----------ITPQDMPDAHKS..LSkaE..KIYYRLQLHKIDKLCSNETSNLLKNILVQLNI.P.FDLLPETITSIRY......QLQ-QGLRLREFAEEVHLSLY.E.gEPMDPKLASKKC-------.----------------------lgdmitkvdq...................................
A0A1E3NR40_9ASCO/461-547              ..edftkkmlgaspitdeqfg-----------------------..--..-..ARYKSLEMEQVDQLTLMELQNIVKNILSSLNI.K.YSGLKGHIVFI--......---------------------.-..-------------------.----------------------rdhifvffnemhsilhsekrgnsv.....................
A5DL82_PICGU/281-380                  .........mselkhsmptni------------KPITIDSVPPE..F-..R..KHYKKLNLDVIDSISDIEVRNTLKNVMLSLLI.CdYQSLP----EMSV......KIANYIRITGEFMDEIHEKLY.D..-------------------.----------------------iqgslrpssy...................................
A0A1E5RNV5_9ASCO/582-709              ...fsmikgsaadaltkldfk-----------------------..-D..P..DKYFSLSMGDVDKMSLVEAQNALKKALYVMDM.P.LNKFETGIILYSL......ISRLERKALYEFIDVLHVFAY.D..TPIELQSYTQNMYNQYLAT.RDFNQVIPPVKKDLDDL-----tiaf.........................................
J7S882_KAZNA/397-527                  .....................LNRVVGDAANKIRYASLKHVH--..MT..K..EKYDELAIDSVEQYTLTELQNIVKRASLELEV.P.PSTLLVNLPRLNV......AIE-QQVILMKFAYWTLQVFA.N..QELDVLSFTERAVEVYETT.GCMTDALRPLEQTMQGL-----rtll.........................................
C4Y1Z8_CLAL4/410-495                  .....hnieepltednvpeef-----------------------..--..R..PFYHRLQLDKINSLSNVEKGNIIKNVMLSLLVtD.FDHLPSMAPKVGA......FLR----ITARFLDELHARFY.E..-------------------.----------------------cgdm.........................................
A3LQW9_PICST/482-602                  .................seei-----GEKNNLITENTVEARF--..--..R..QYYSRLELHKVDNMTKVEMSNLIKNLMLSLLI.SdFSNLAVNARKFGR......FLK----LALHFLDRLHSVIY.V..Q------------------.----------------------gdpnikpsfyvknsqdiqamenlgqclhgmlenv...........
G8C1Y1_TETPH/944-1078                 .....................IRKLEGNKYEKVMFDSISKTHPG..IT..K..KKYDDLHVDNVDSIDMVQLQNIVKNIILLFEI.P.LSKLTKKLPLIAI......YIKYERTFLLNFANQLHYQIY.N..ETIDIKRFINIVYTQYIDG.ISLENLDHPLESCLEDLYIKI-k............................................
A0A1E4TSS9_PACTA/475-608              ..tiggdsaaidadflqsngf-----------------------..--..G..KIYFELQMDEIDKLTLVELQNKLKELLLVLFI.P.YDRLSIALNNITR......FFRNDYIRLISFIKRLHDIIY.R..N------------------.----------------------ngsgvklpnvykfscfdgefdsdndylqdevanfqncldemlknv
A0A1S7HNH7_9SACH/810-944              .....................LRKLQGDPARKITFEVARRSRPD..IN..A..TTYDHLMVNKVDSIDMIELQNIVKNIILLLDI.P.FNKLTKKSPLVAI......YLKYERPIFSHFANRLHFQVF.N..EAIDLRRFSNEAYEQYTEN.HDMRAIKHPLQTCLDNLHQKV-i............................................
G0WD36_NAUDC/394-528                  ....................i-RDIQGDAAERIKYDRYQLMKLG..IT..E..DLFKTYGIDEVEILDKISLENIVKRTMVLLNI.P.FNELNTKISRIAV......FLRYEKPLLRKFVTELHMATF.G..TSADLIYKANRATKQFNTT.GDLTHIDHPLNRCLDKLLNQL-i............................................
A0A2U9RAK6_PICKU/221-342              ............klstqiqgs--------------ENVLKLSND..YF..G..SKYSFLEMDKIDSLSLFESQNLLKNIVHVLNV.N.FTGLKSSILFI--......-----RDEVFPFFNKIHNLLH.S.rKSGNLLVVNNSANLTLSDR.ENLKQCMHLLIEDVESL-----kqs..........................................
A0A1Y2F6R8_PROLT/690-787              ...........pdydahrlgl-----------------------..--..S..ELYETLALAQVDSMDTHMRGNLIKNIAIQLNV.P.LHDLSSSICQLGSeaenreMLVHETIKLRMFAEQVHASLY.-..-------------------.----------------------agariegsvvqdac...............................
A0A2V1AUI7_9ASCO/301-407              ............ngenveacf-----------------------..--..R..PYYSKLQLDKVDGLSDVEKSNMIKNLMLSLLV.SdFDHMRTMAPRVGD......YLR----ITSRFLDKLHARFY.E..-------------------.----------------------cegyspskylrdysvesmedfqecldgmmeli.............
G8ZUK0_TORDC/799-933                  .....................LKRLEGDQSRRITYEVARQSRPD..ID..R..ALYDKLMISKVDSIDRVELQNIVKNLILLLEI.P.FNKLTKKGPLVAI......YLKYERPIFSYFANRLHFELF.N..EAIDMMRFTNEAYDQYTDT.HNMNTIKHPLESCLENLYQKL-v............................................
ADY3_YEAST/655-789                    .....................LKKLYGDPSTELNFETVGKSFPH..IT..K..EKYDSLGLDILTDLTYVQSQNLIKNLLIVLDI.P.LKTFLKIVPTIVI......QLRCELTLLTKFANDLNLKVF.G..KQLDFKSRRKVAMNEFLNN.HDIAEVKHPLEYDLQALFKYF-f............................................
J8Q450_SACAR/654-788                  .....................LKTLYGDPSTELNFETVGKSFPH..VT..K..DKYDSLGLDILTDLTYVQSQNLIKNLLIVLDI.P.LKTFLKVVPTIVI......QLRCELTLLTRFANDLNLKVF.G..KQIDFKSRRKIAMNEFLSN.HDIAEVKHPLNYDLQALFKYF-f............................................
L0PA02_PNEJ8/464-576                  ................hhtkp-----------ITPQDMPDAHKS..LSkaE..KIYYRLQLHKIDKLCSNETSNLLKNILVQLNI.P.FDLLPETITSIRY......QLQ-QGLRLREFAEEVHLSLY.E.gEPMDPKLASKKC-------.----------------------lgdmitkvdql..................................
A0A1X7R259_9SACH/346-478              ...................yq--TTRGNSKDSLTYDDVKSAD--..VT..R..VVFDSLELEQIDKLDMVTLQNELKKICVGIQT.P.FNKIQRKVILANV......LIKNELVHALNFINLLYFQLH.G..DNLHFRELENTAYRQYLKI.RDVDNVQHPLKHILDEMYQHI-l............................................
CNM67_YEAST/442-576                   ...................fg--NLEGNTSERITIKNILQSRPD..IS..A..EECNFLMVEQIDSANLTTLQNTVKEIVLAVGI.P.YPKLRRKIPLLAI......KLKYENIMLSNFAQRLHRQVY.S..QEMNLKKFTDQAYYDFMST.RRMDSIDHHLERCLDHLYDHI-l............................................
#=GR CNM67_YEAST/442-576        SS    ...................HH--HHH--GGG---HHHHHHH-TT..--..H..HHHHHHTGGGGGG--HHHHHHHHHHHHHHHT-.-.GGGHHHHHHHHHH......HHHTHHHHHHHHHHHHHHHH-.-..----HHHHHHHHHHHHHHH.--STT---HHHHHHHHH--XX-X............................................
A0A1L0DGH0_9ASCO/396-505              ..........aldassipeef-----------------------..--..R..PYYHRLQLDKVETLTSEEKSNLIKRIMLSLLV.SdYDHLSSVMPQVGS......YLR----LTSKFLDNLHLKLYyN..NEIG---------------.----------------------plrylqdynlhtddgleecldgmfnmlm.................
A0A1E3PFI8_9ASCO/877-981              ................dampd----------------ATKVYAN..PN..R..KLYNRLKLSELDEMGVIQLRSTLKKILIFLNA.T.SSSLRNKLDLM-I......AREEEAIVLAKFFEDLHLAIY.G..YKVISASVNSKAYK-----.----------------------lcleqtlai....................................
A0A1E4RGF6_9ASCO/224-339              ....................l-TKKIGNPTQMINESNLEPKF--..--..N..HYYKKLQLYKLDHLSNVELSNIIKNIMLSLLI.TdFNNLPRMMSKLGK......YIQ----ITNNFIDQLHHRVY.N..NNTN---------------.----------------------psmylrqmeldlkdlqlclndllnk....................
A0A4T0WWG4_9ASCO/453-522              yndlktqylgtdpitqdrfgg-----------------------..--..-..-FYQLLEMDKVDKLTLTELQNIVKNILKSLNI.K.FSDLKQNIIFI--......---------------------.-..-------------------.----------------------rddifn.......................................
A0A061ASU5_CYBFA/427-556              .....................LNKVRGNLKDSVTPEKYPELMSKttCG..V..PLYEDLKLAEVDVLSLVQAQNMIKNVLINLGV.P.FDKVKEMIPNIAL......QSQ-RESILREFVNKTHKLLY.D..EDMALDVY-----------.----------------------mdldqrgkehltqcttqmyknlellyt..................
A0A1E4T8Y8_9ASCO/350-451              .............kpgelrmp----------------------S..SK..D..NLYIDLKLDEVDKLSYVELSNKIKTIMLLFCV.R.YESLEPLLKFIG-......---KTRYFYQNFLEVLHRRLF.N..NQ-----------------.----------------------rladhikikgnlttfddenikdfk.....................
Q6FP18_CANGA/394-528                  ...................ll--SITGNTNNMLSFEKLKQLDNS..FC..K..EEYVSLKISEIEDISLVQLQNMAKMICMYFRT.P.FDKLDIKLPLAAI......QIIHERKILIHFANILNEYFM.S..KPLSMKKCTDSAYCEWQLS.HNIFRIEHPLKFKLEELYTTI-l............................................
A0A1S7HAX5_9SACH/810-944              .....................IRKLQGDPARKITFEVARRSRPD..IN..A..ATYDHLMVNKVDSIDMVELQNIVKNIILLLDI.P.FNKLTKKSPLVAI......YLKYERPIFSHFANRLHFQVF.N..EAIDLRRFSNEAYEQYTEN.HDMRAIKHPLQTCLDNLYQKV-v............................................
A0A1G4MJ78_LACFM/748-882              .....................INKIEGKSSKKITFQVASHSHPH..LT..K..RIYDSLMVDAVNNLNLVELQNMVKNMILLLEI.P.LSKLTKKIPLVSI......YLRYEKSLCLHFANRLHHLVF.H..EAIDIKRFTNVAYGQYLES.HDICHLQHPLEKCLENLFKEV-s............................................
A0A2P7YCJ4_9ASCO/262-368              ...skkenttpinsdnvdacf-----------------------..--..R..PYYLKLQLDKVDGLSDVEKSNVIKNLMLSLLV.SdFDHLQKMAPRVGD......YLR----ISSRFLDKLHARYY.EcgEYCPLRYLRD---------.----------------------yavetmddfqa..................................
A0A1G4JID3_9SACH/806-940              ....................l-AKACGNPARRITFQMASQVRPH..LT..R..REYESLMVDAVNDMDVVDLQNVVKNLILLLEI.P.LSKITKKMPLVAI......YLRYEKSICLHFANKLHNMIF.R..ETIDIKRFTNSTYAQYQEN.HDICHLEHPLEACLDNLYRAV-s............................................
C4R740_KOMPG/208-306                  ..........atrigkvrsln--------------------KSD..FE..G..DKYNELGLAVVDNLSLRRLQNFVKQMLVDLNV.P.YARIDSIVEHH--......------LVLQSFVQDLHRMIY.S..NSIDPKLTKQC--------.----------------------cqgmnayikrh..................................
K0KI32_WICCF/329-449                  ....................l-KSVLGDLEEAAIESKYPSLKETesNG..K..TVQEYLEIDQINDLNLSKSHRLLKNILINLEI.P.LSQAHIMIPKIAN......LLQSE-DILLNFANRVHLLLY.N..KKLNMSKFQRK--------.----------------------keggqhlhqcttsmf..............................
B6JY04_SCHJY/552-663                  .........hvskplteqdmp------------------DAQLHlpNS..E..KIYYRLGLDKIDRQCNVETANMLKTALVQLDM.P.FDLFPQAIGQVRR......QLQQGRRL-YTWAQSLHRHLY.D..EEMS---------------.----------------------pglvsrkclmnmmneitqh..........................
G8JUR7_ERECY/711-845                  .....................LEKLKGNPAEMISFESAQKIYQN..LD..R..KTYNNLMVEQVNQLDLVELQNVVKNVILLLET.P.FSKLSKKMPLVSI......YLRYEKSLCFHFANKLHYHVY.Q..EPIDIKKFTNKAYSQYLER.HDLTKIKHPLEFCLDKLYEEV-r............................................
A0A7H9HRS2_9SACH/939-1073             .....................LQKLQGDNSKAITFHIARQSRPD..IT..R..DLYDKLMISQVDCIDMVELQNIVKNLILLLEI.P.FNKLTKKVPLVAM......YLKYERPIFSHFANRLHFDVF.N..EAIDIKRFTNEAYDQYTET.HNMASIKYPLEACLENLYQRL-v............................................
J7RZC6_KAZNA/453-584                  ....................y-NLLEGDKDKSVLWEDLCSIQPE..--..-..ATEEYLQFERFDSLTYVELQNIVKKLVVMLMI.P.MDKVDKRLIMTGI......ALKYERNVYSYFANRLNYLLH.K..EKIPIKEYQQCAYQQFKCT.GTLEGINHGLTDKLEELYNDI-a............................................
C5DD50_LACTC/805-939                  .....................LARLKGKASRKITFQMASQSRPH..LS..R..KTYDSLMVDAVNDMDMVELQNIIKNIILLLEI.P.LAKITKKMPLVGI......YLRYEKNICLHFANKIHYLMF.R..ETIDIKRYTNVAYGQYLDH.HDICHLDHPLESCLDNLYKEV-s............................................
I2GXL5_TETBL/391-526                  ...................kn--LLIGDKSKKITYENIKSSYPD.vTI..S..DYEETLNINHIETLSLVELQNIVKHLQLTLQV.P.LSKLQMATDMALI......TYKLEQPIFVGLINNLLLQAQ.L..KQISYKELSDKAYFNYQKV.RSLKKVNHPLQDFLKDSYYHL-l............................................
A0A1X7R6P4_9SACH/549-683              .....................LAELIGDETKKITYEQMLLNNSD..TS..R..DTYDFLEVDDVDKLTMVELQNVIKNLIILLNI.P.FSKLAKKIPLIGI......YLIYERNMYAYFVNRLYYQLN.G..KQLMLTDYNREAFNQYITT.NSLNNIRHPLEECLETLCNRI-i............................................
A0A1G4K4A7_9SACH/819-953              ...................ld--RTLGDQSKVIDFKMASRTRPH..LS..R..KLYDSLMLDAVNDLNLVEVQNILKNIIILLET.P.LSKLTKKMPLVSI......YLRYERTICLHFANKLHFLIF.N..ETINIKRYTNIAYAQYNED.HDICHIQHPLEACLEDLYAEL-c............................................
SID4_SCHPO/545-653                    ...tsqpltslnmpdsrfnla-----------------------..KE..K..QLYYRLGLQHIDQQCSVETANMLKTVLVQLNI.P.FAIFPSTIGQVRR......QLQQGRR-LYQWARNIHYLIY.E..ENM----------------.----------------------rdglvskqcladmlkkir...........................
H2AW62_KAZAF/432-570                  .....................LKFLEGDFSKRITFETIHQKNPE.kFT..K..EIYDYLEFPTIDNMNLIELQNIIKHFSLFFEV.P.LSKFFKKLPTICI......YLRYERNLLHFFVDRLNYQIY.NpsKKINFKSYTVDAYQQYLKNgNSFEDINHPLQKCLDDLYNEI-i............................................
A0A7H9B3K1_ZYGMR/777-911              ....................f-QKLQGDISKRINFEIAHKSRPD..IE..K..TNYAALMIDKVDYIDMVELQNIVKNLILLLEI.P.FNKLTKKSPLVAI......YLKYERPIFSHFANRLHYEIF.N..EPIDMKGFTSDAYDQYTEN.HSMTTIQHPLESCLDNLYQKIV.............................................
J4TU05_SACK1/443-577                  ....................l-GNLEGNTSERITIKDILQSRPD..IS..A..EECNLLMVDQIDSASLTDLQNIIKEIILAIEI.P.YPKLRRKIPLLAI......KLKYENIMLSNFAQRLHRQIY.K..QEMNLKKFTDQAYYEFMAA.RRMDSINHHLERCLDHLYDHI-l............................................
Q6CQ58_KLULA/615-749                  ....................y-EKVKGNAADKITPDTLMKIHTH..MN..K..ESYENLELDTIDNLNLVECQNTIKNIVAILDI.S.YSKLSSKLPLVNI......MLRYEKTMLFHFANKVHNLLF.H..QEIDFKTFTKKALENYWTH.RNAKEIQHPLEQCLKDLYKSV-s............................................
A7TM73_VANPO/820-954                  .....................IKKLEGNRYQKITYEIAKKSRPE..MD..R..HMYESLMVDEVDTIDMTQLQNIIKNLILLLEI.P.FSKLTKKLPLIGI......YLKYERPILIHFANQIHYQLY.N..EEIDTKYFTNKVYTEYIES.YDLNGLKHPLEICLDSLYQRI-s............................................
J7S4N5_NAUDC/489-623                  ....................i-NIIVGDLREALTFNIVRSTRPD..VT..K..ELYNLLMVDKIDDLNLTQLQNIIKNMILLFEI.P.FDQFMGKVPFLVI......SLKYEKALLAFFANRVFYHLY.N..QRIDFKELSKEAYLQFMKS.KSMNNINHPLQPILEELYRVV-v............................................
I2H6G7_TETBL/875-1010                 .....................LEKLTGDKSLRITENNIRNTFKG.dGS..N..SLIENLKLDQVDELTMIQLQNALKNIIVSLKI.P.FDKFSYKMPLITI......YIHLERVIFLKFINRIHFKLH.D..RYFEMERFTTEAYVQFMNT.HDLNTVKHPIATYLHSMLKEL-e............................................
Q75E63_ASHGO/723-857                  .....................LEKLKGNPADMISFESAQRIYHN..LD..R..KMYNTLMVDQVNQLDLVELQNVVKNIILLLET.P.FSKLSKKMPLVSI......YLRYEKSLCFHFANKLHFQVY.Q..EPIDIKKFTNDAYSQYLER.HDITKIKHPLEICLEKLYDEV-r............................................
M7PIM2_PNEMU/610-722                  ................hhtrp-----------ITPQNMPDAHKP..IS..KaeKIYYSLQLYKIDKLCSNETSNLLKNILIQLNI.P.FDSLPETITSIRY......QLQ-QSLRLREFAEEVHLSLY.E.gEPMDPKLVSKKCL------.----------------------gdmitkvdql...................................
G8YBG6_PICSO/465-564                  .lkrqlgvpscsisrdsvsee-----------------------..-F..K..KYYDKLQLSRVDSLTKVELSNLVKNIMLSLLI.S.--DF-EHLPSVSV......KIGKFFKLITSFMDQLHSIVY.D..D------------------.----------------------sstsvkpshylk.................................
A0A1E4SIU0_9ASCO/494-609              .................leae----IGDKAKSITMDTIDDRF--..--..H..AQYKKLQLDKVDGLSKVELGNTLKNLMLSLLI.SdLDHLPSQAAKYGR......FLK----MSIQFMDNMHASVY.T..QA-----------------.----------------------sgvkpsdylrmhderalqhlgecldgm..................
G0VEX6_NAUCC/465-599                  .....................LKKKMGDATEMITFSNTCKVRLD..IT..K..DMYERLMVDDVEKMNLVELQNIIKNLILLFEI.P.LNKLTKRLPLMVI......VFMYEKPLFSYFVNRLFYQIK.N..EQLDLKHFTDDTYRQYLEG.NSIKNLNHPLKDVLEELFQYI-v............................................
A0A1Q2YK12_9ASCO/465-543              ......rkmlgaspitdeqfg-----------------------..--..-..ARYKSLEMEQVDQLTLMELQNIVKNILSSLNI.K.YSGLKGQIVFI--......---------------------.-..-------------------.----------------------rdhifvffnnmhsilhsekr.........................
G3B4B7_CANTC/253-347                  .....ksesslisketlearf-----------------------..--..Q..SLYDSLNLADIDQLSRTQMANLIKNLLLTLVL.N.FRELPGQLSRL-I......KVH---KIALRFIDQVHGQLY.V..-------------------.----------------------nspsplmyfdtnkp...............................
A0A1E4TDC1_9ASCO/215-303              .............ssyyesrs------------------AEKLA..RQ..Q..AIFSHYELEDVENLSLTDSHNLIKNILLQHDC.P.LSKIKTCSMNYRS......SMK-ELHDLRNFADSVHKVVY.N..SQ-----------------.----------------------hrhp.........................................
G0VHZ0_NAUCC/351-485                  .....................LELLEGDKENMVVFDKETLTRFG..VN..G..DIAKYLSLTQVNSVDRITLINTVKRIMIFLQM.S.YTDLPDKIQRLAV......YLQYEKPLLRKFVNELHRMVF.G..EPIDLVNKAAVAYSQFSKT.GDMNSINHPLEKCLNNLIDHV-a............................................
A0A2H0ZJ75_CANAR/329-416              ...........vnketvepcf-----------------------..--..R..PYYSKLQLDKVDELCDIEKSNVIKNLMLSLLV.SdFDHLQQMAPRVGD......YLR----ISSRFLDKLHSRFY.-..-------------------.----------------------lcgeycpsrylrd................................
H2APC8_KAZAF/394-526                  .....................LNKLRGDSSELLTFKDFKNSD--..ID..K..RLYQALQVDKVEQLDLVQLQNKMKKVIVDMQT.P.LDKLDAKLPLANL......LIKSELVITLDFINRLYQTMY.N..EGLDFNHYTEEAYLQYRKS.NYLDPWQHPIRPIIDHLYNDI-i............................................
#=GC SS_cons                          ...................HH--HHH--GGG---HHHHHHH-TT..--..H..HHHHHHTGGGGGG--HHHHHHHHHHHHHHHT-.-.GGGHHHHHHHHHH......HHHTHHHHHHHHHHHHHHHH-.-..----HHHHHHHHHHHHHHH.--STT---HHHHHHHHH--XX-X............................................
#=GC seq_cons                         ..........................Gp....lp.p.h.p...t..hp..c..phYppLplcpVDpLshlElpNllKNlll.Lpl.P.ascLppplshlul......hLp.-t.lhhpFsscLHhhla.s..pths...htp................................h............................................
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