#=GF ID   SLC25_like
#=GF AC   PF18405.4
#=GF DE   Mitochondrial SLC25 homolog
#=GF PI   Serine_protease;
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Swiss:Q5ZWE8
#=GF GA   34.50 34.50;
#=GF TC   39.80 96.10;
#=GF NC   34.40 30.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   28966893
#=GF RT   The Legionella pneumophila effector Lpg1137 is a homologue of
#=GF RT   mitochondrial SLC25 carrier proteins, not of known serine
#=GF RT   proteases.
#=GF RA   Gradowski M, Pawlowski K;
#=GF RL   PeerJ. 2017;5:e3849.
#=GF RN   [2]
#=GF RM   28504273
#=GF RT   Legionella effector Lpg1137 shuts down ER-mitochondria
#=GF RT   communication through cleavage of syntaxin 17.
#=GF RA   Arasaki K, Mikami Y, Shames SR, Inoue H, Wakana Y, Tagaya M;
#=GF RL   Nat Commun. 2017;8:15406.
#=GF RN   [3]
#=GF RM   28933649
#=GF RT   Legionella blocks autophagy by cleaving STX17 (syntaxin 17).
#=GF RA   Arasaki K, Tagaya M;
#=GF RL   Autophagy. 2017; [Epub ahead of print]
#=GF DR   INTERPRO; IPR041000;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family includes distant homologs of mitochondrial carrier
#=GF CC   proteins (MCs, also known in mammals as solute carrier family
#=GF CC   25, SLC25). Sequence analysis suggest that it is likely that
#=GF CC   Lpg1137 forms a standard MC structure with a pseudo-threefold
#=GF CC   symmetry with six transmembrane helices. Furthermore, sequence
#=GF CC   logos of the repeats in homologues of Lpg1137, compared to
#=GF CC   sequence logo of the eukaryotic mitochondrial carriers support
#=GF CC   the structural similarity by highlighting the conservation of
#=GF CC   structurally important Pro and Gly residues (e.g., Pro at
#=GF CC   positions 15 and 239 in the logos or the YxG motif at positions
#=GF CC   45-47 [1]. It was previously thought that members of this family
#=GF CC   are serine proteases that target the mitochondria-associated ER
#=GF CC   membrane (MAM) and degrades STX17 (syntaxin 17), a SNARE
#=GF CC   implicated in macroautophagy/autophagy as well as mitochondria
#=GF CC   dynamics and membrane trafficking in fed cells [2,3].
#=GF SQ   21
#=GS A0A0W1AAH8_9GAMM/48-342   AC A0A0W1AAH8.1
#=GS A0A098G7K4_9GAMM/38-331   AC A0A098G7K4.1
#=GS W0BAG2_9GAMM/46-332       AC W0BAG2.1
#=GS A0A378LMZ8_9GAMM/22-295   AC A0A378LMZ8.1
#=GS A0A0W0TMF6_9GAMM/1-231    AC A0A0W0TMF6.1
#=GS A0A078KTX4_9GAMM/37-326   AC A0A078KTX4.1
#=GS A0A078L176_9GAMM/33-313   AC A0A078L176.1
#=GS A0A098GH05_TATMI/38-325   AC A0A098GH05.1
#=GS A0A0W0ZY72_9GAMM/173-458  AC A0A0W0ZY72.1
#=GS A0A0W0VC51_9GAMM/21-301   AC A0A0W0VC51.1
#=GS A0A0W0VJH6_9GAMM/23-307   AC A0A0W0VJH6.1
#=GS A0A433K0J0_9GAMM/22-299   AC A0A433K0J0.1
#=GS A0A0W0TM72_9GAMM/24-306   AC A0A0W0TM72.1
#=GS A0A433JM47_9GAMM/20-300   AC A0A433JM47.1
#=GS A0A0W1AMD2_9GAMM/204-490  AC A0A0W1AMD2.1
#=GS Q5ZWE8_LEGPH/26-304       AC Q5ZWE8.1
#=GS A0A0W0Z5C9_LEGSP/26-315   AC A0A0W0Z5C9.1
#=GS A0A0W0VLF0_9GAMM/23-296   AC A0A0W0VLF0.1
#=GS A0A378LSD9_9GAMM/200-483  AC A0A378LSD9.1
#=GS G9EIQ5_9GAMM/29-322       AC G9EIQ5.1
#=GS A0A6F8T413_9GAMM/27-311   AC A0A6F8T413.1
A0A0W1AAH8_9GAMM/48-342              ...WDFLNFMTKASVISGAIVSVQSPIKTILVK.GTQSG..KLT.A-AFtvpatSATSFpfqAVVKSLYAGTFS.GLKGSLMRTAYVTNVKGSSA..........KSEEHAVEPSAKTRG.......QF..---PFL..FWSAVGESLVTGRSNS..VSQLQKLGILTP.A.....NmeiirfrFNKESVVNNAKLMSTGFAAKTSKSLLNLYFLCVLEEIM....ANKI.TF.GPESSRHLVSGVMTGFTATMFSFPFDYYADIMQGKTTV.QNRKLQSPYSFQVLGSAAKEMFL.NPYGTSRYFFT.QYFKQVPVRAVLTGAIFGIISSVSDVLGEKPAE----nmy
A0A098G7K4_9GAMM/38-331              ...WDCANLATVTFLTSTSIAALQSPFKAWILN.LSKDG..SFS.S-AY.....KGGVF...GFVRAAYSGYTA.SLSSSAIRSAYVTGAKNNRPv.......elMTEGMAKEENLVVKDegl.kkaLF.rAKMGYV..TVAALGEIFVTQIPES..LSLLRKIPRLLP.P.....N.......FKWYTLNNAYQLMSGGFMARYLSGVVSFTSLCIIEDQI....AEAL.PI.KDKKTKHFMAGALSGAIAATCSYPFAAFKDYTLVRATV.NNGKLVNKKATSIIVDMTKQFWT.SPKEVANSVVI.HALKQLPLRIALVAGIFGTVGFVNETCGPAPLDEVIP...
W0BAG2_9GAMM/46-332                  ...WQASNFVVTVATTSTAIALVQNPLNGIVAN.LMRHG..TVLaPVGP.....GAGRL...AAVRGLYAALGS.SMVGSSLRTTYVTGAKKATA..........EVGVEEIKPEVEVSGs.....gVV..QRVGLV..SAISFGDLAVTKIPAT..REFLHKLHV-IP.D.....D.......FKM-NFYNFRQMAATGFFARYSGGLVSFSALCLVEGVY....ARYM.PF.SHESTRHFAAGAASGMTAAVFAYPFSYYADSVLYRARLgSDGRLQIPGLLDAGREVAAYVREvGFVEASKKAGR.DFLKQAPVRMARTGLTFAIVAGVSAALGSEPLASI--g..
A0A378LMZ8_9GAMM/22-295              ...YFLTNLCFKTAVISLSVSTVTQPFKAVLNH.VQTN-..S-L.N-GL.....NGG--...-IFRSLWRGFLPyAVAGQQRGAVAVTSKQANR-..........EVVEEEFE--FSYRQ.......YW..--LGTL..VFSQA-DLLFANALIE..KAKLENAGIITK.S.....N.......FKW-SLVNYKQLTFANWGSRSLSSFMNFSALGIVGDYV....TSRY.HF.KNDAYNKIAGGATAGVIATLFTSLPNSYADRKLLASKI.ENGRLLTLTPYTFFRQAKSHVATvGVKQALTQFVFcNYLKEVAVRSPMSALTFATIFYLDNIMGVYPLEQI--g..
A0A0W0TMF6_9GAMM/1-231               ..m------------------------------.-----..---.----.....-----...------------.------------TGVKGNKPveglseeaasLIREEELMQEGRMKQ.......LS.rQKMGFV..ASATFGDMCVTQVPGT..YTTLRKIPGLLP.E.....N.......FRFSKPANIFQAMKAGFIPAYLAGLTNYTSLLVMEPYIagymAKNL.RI.EDRKAQHFLAGAVSGSLAAFFAYPFAATCDYMVVRTSVnDQGILSSRSTLSIAQEIAKTVRD.NPKQAMHTFFG.NAAKQLPIRMGLTAIIYSIVSGVGETLGTEPLKAVVP...
A0A078KTX4_9GAMM/37-326              ...WNGLNFTTVAAVTSGAVVAIQSPVKTVLVN.LTKDG..NFL.P-SY.....SGGTF...GLFRAVYAGTLA.SLTGSSVRTLYVTGTKKHKP..........MELTPEIEEAIEVQEkt..gipKF..SKTGYV..MAAAFGDIIVTQIPES..LSHYKKMPGFLP.K.....D.......FQWKTLNNSRQLMLGGFMPRYLSGVVNFSALCVVEDKI....AKNL.PI.DEKNTRHFTAGALSGMTAAFFSYPFTLFKDYTLTQTTVnEQGELRAKNSFTLLKEVGELVVQ.NPKEMGKTFVK.NAVKQLPLRMGLTGAIFATVAGVGEILGSEPLDAVVP...
A0A078L176_9GAMM/33-313              ...WRALNFTTVAATTSAAIVSIQSPIKTVLVS.LSKDG..TFF.P-PF.....SGGTL...GLVRAAYAGTLS.SLSSSSLRTLYVTGTKKIRP.........tATETREIEETVRVNE.......--..--TGYV..MAVSFGDILVSQFSES..LSQYKKMHGFLP.K.....D.......FNWKTRHNAYQLMKGGFAPRYLSGLVNFTSLCMVEDRI....AESL.PI.EDPTARHFAAGALSGITAGVFSYPFSAFKDYVLAQSTItEKGELQTKSSFAVLKQAGALIKQ.NPREMGMTFFK.NAAKQLPVRSGLTGTIFATVAGINELLGPEPLG----als
A0A098GH05_TATMI/38-325              ...WEALNFLFVTGVTCGGVVIFQSPLKTVLTN.LTIDG..TVL.P-KYp..ltSIGTF...GFFRALYAGTSA.SFAGSAARTAYVTAAKNNKP..........IEVKESTPHEEKLSG......lNL..NKAGYV..MSAAFGDYVVTQIPKS..LSQLRKIPNLLP.S.....G.......FKWYTRNNLYQLWTGGFPSEYFAGFANFGALCVLEEEL....AKRL.PI.EDEKIRHLLSGALTGVGAGVISYPFALLRDYTLVHANV.TNGQLRIDSTATILKKLAAAYLE.NPKEAGLAFLA.NAAKQVPIRAILTGGVFSIVASVGATLGNAPLSKIIP...
A0A0W0ZY72_9GAMM/173-458             ...WSGANFVTVTLATCVSVVGVQSPVKTMLVN.LSKNN..TVI.P-TY.....SGGIW...SLAKVMYAGTGA.SFSGSLVRSGYVTGAKGNS-..........KPLEDGVHETGKEKS......rKYvtVNYSYV..AAMALGDILVTQIPES..LSTLKKVPGLLP.P.....D.......FTWKTLNNSWKLMMGGFIPRYGSGMVNFACLCVVEERI....AKGL.PI.QDKNMAHFTSGMLSGMTAAVVSYPLTSFKDYTLVQSTV.KDGRLHNANAIKLTQELFYCFIS.NPGASLKSFGS.MALKQVPMRMGLTGIIFALVAGVGETMGSEPLAKVVP...
A0A0W0VC51_9GAMM/21-301              ...YVFANLVFKTAAISFSVSAFTQPFQYMLTR.MQLPG.aSGA.DSAF.....KQG--...-LFRSMYRGFGSyAIAGQKRGAVAVTAKQQNR-..........ESAEEQLEHEVHPHK.......RV..--LGTF..LFSQA-DLLVSNGLVS..KAKLESAKIVTK.G.....N.......FNW-SVANLWHLTTTNWGSRSIAGFINFAAIGMMGDSI....ASLF.KF.NRDIYNQVAAGATSGVIATFLTTIPNAYADKKLLASKM.NEGRVVTVSPFSMFSQAKVHMREmGAKEAMKTFFKvTFLKEALIRSPQTALTFSIIFGLDHAMGTEPLKRVWP...
A0A0W0VJH6_9GAMM/23-307              ...YTFANLAVKTGTISFSVSLLTQPFNFVLNR.IQ---..SGT.PSAV.....SGG--...-LFRGMYRGFLPyAIAGQKRGAVAVTAKQTNRVq.......eeLVEEEGIDMVLLQRQ.......RFmkAVMGTV..AFSQF-DLLVSNGLGG..KSRLENLGIITK.S.....N.......FKW-SFTNWWKLTTVNWGSRSSAGFVNFAAIGVVGDYC....SSLY.KF.NDELYNKMLGGATAGVLATLFTTIPNSYADRKLLASKV.ENGRLLTVTPYTMFKQMKSHVNTiGVFEAVKTFIKfNYLKEVAVRSPQTALTFGIIFGIDHMMGDEPLRRVWP...
A0A433K0J0_9GAMM/22-299              ...YIVSNLVAKTAGISFTVSLVTQPFQSLLTQ.LQMSG..TS-.--AV.....SGG--...-LFRGLYRGFLPyAVAGQKRGAVAVTSKHANKE..........AVVEEEIEAELPLSR.......KW..--AGTL..AFAQA-DHFISNALYG..KAKLTSAGIITA.D.....N.......FKW-SPFNIYKLTMVNWGSRSIAGFVNFAAIGFVGDKF....SSFY.HF.EQELLNKIAGGATAGVFATFFTTLPNAYADRKLLATTV.ENKRLLTTSPFTMFRSMEQHVKKvGLKSAASELAYtNFLREFIIRSPQAALTFATILGMDYMMGTEPLKAIWP...
A0A0W0TM72_9GAMM/24-306              .lk--GADLIFKTSITSLTTSLITAPITLLLSN.KQLST..TIK.P-T-.....---PL...AFAKSSWQIFQSqAIANQKRGAVSVTSKHINKEng......peGVPTQHKEEAEPIQN.......-Y.nSFFTSL..TFSQA-DTALGSVFNN..RAKILSGGIVKP.V.....K.......LT---GYNIRQLFLMGYPVKSLSNFMSFTALLTLSDSI....TNQL.PI.ENSAVANFVGGGLAGAVSSLLTHPLNASYDRIILGTRMdSEAKLIRVSSLSFFKEKMNYAKTiSLGEIAQNFWL.ITRNELPVRMLSTITIFSIIQGFNYLMGDRPVSHFLP...
A0A433JM47_9GAMM/20-300              ...WELMNLGTSILATSTVISLIHPPINYIIFKkMKSAGmgNAA.ANGE.....QASIL...SFINCCYK--NS.NFAGQSARTAYVTGTKKTSMsee....nalPHEASELKENVATTK.......KL.kQEVGFI..FSASLGEAGLTQLFTM..KAYLGQAGI-ID.S.....K.......FNWKTYHNIKVLSRLGFFPRFLANVGNFSALCILEEFF....TQNV.FK.NNSASSHFFAGALSGMTASLVTSPLTYWRDQLVCGSKV.QEGKLCSPPTFSVLHGFPAHMRT.PA------FFI.----AVSLGMTRTGLTFAFVSGLMAALGNEPLSK---fn.
A0A0W1AMD2_9GAMM/204-490             spv---YNLMFKVPVISAGITSVVQPTNLLMAN.IINHS..NPI.K-GM.....PSAPS...AIFFALYKGFGNnVVAGQMRGAVSVTAKQSQGV.........eVAKEAELSTESSSAN.......KG.sKMISTV..SFAQA-DTLVAQYGNRgvLTGYYSNEGIFK.KmacplE.......KIPLTINNVKQIVAMGYPIKTTGGLVTYGAMVIGSDFI....ENQQ.FL.SNPTTNKVVASMIAGGLASIVTTPISIINDKVVLSTTI.NNQNQLSRLTFTQSMEVAAHFVK.DA-----SFKT.KLAYAGPMNAVRSTIIFGTLTFANELLGDQPLKKV--k..
Q5ZWE8_LEGPH/26-304                  ...YEMANLVFKTGAISFTVSAGTQPFQYLLNK.LQFSQ..SGT.PSGL.....SGG--...-LFRGMYRGFLPyAIAGQKRGAVAVTHKQTNK-..........VTEEEEFE--APFRQ.......RW..--WGTI..FFSQA-DLLVSNGLSG..KARLQNVGVINA.E.....N.......FKW-SLSNFWKLTSVNWGSRSFAGGVNFALIGFAGDYV....SSFY.KF.DKDLYNKILGGATSGVIATLFTTAPNAYADSKLLQTKVaENNRLITVSPYTMFGQMKSHVKAvGLKEAFMTFFKvSYLQQVAVRAPQAAITFALIFGMDEYMGPQPLKKVWP...
A0A0W0Z5C9_LEGSP/26-315              ...WWAANMFVKISMTSASISFLTTPLNVMLTN.SQMGG..TGT.N-RF.....IFG--...---ANLLKGLTSnVIAGQKRGAISGAAKTVNTS..........--NEEQVGQRTEHGRgkgqvtsFF..ARYPYLqpLIFAQGDLAVSQIFAN..KGKLQAADIIKTgT.....P.......FKM-NFHNMRQLFAMAYPVKTLAGGVNFYSICYLSNFI....TGWMaNFsQNPAMNNFVGGAATGAIAAAITHVPNSVADAMVLKSRVdSQGKLSRVSTLGFFKEQINHVKTvGIKDSILPFLM.RSKVELPLRTANSMVIFGMLQLMFHVMGDEPLAR---fy.
A0A0W0VLF0_9GAMM/23-296              ...YDLTNLTFKTMVISFVVSATTQPFQIVLTR.LQQQ-..SSA.PSS-.....NKG--...--LLGLYRGFLSyAIAGQKRGAVAVTSKQTNR-..........ESPEDEIR---TIQQ.......RW..--LGTF..LFSQA-DLGLSSALSN..KAKLQGGAIITK.T.....N.......FKW-SLENFWKLTKVNWGSRSIAGFINFSAIGFMGDYI....SSFY.KF.NNDFYNKLAGGATSGVVATIFTTIPNSYADKKVLASRV.VDGRLLTVTPYTMFQNTKSHVKTvGLKEATMAFFKlSFLKEVLIRSPQAAITFGLIFSLDHIMGPEPLQKVWP...
A0A378LSD9_9GAMM/200-483             ...WNGANFLTVAATTSTCIVAVQSPVKTMSLS.LVKNG..TFL.P-PN.....SAGLS...NIMGILYSGGKA.GAATSLGRSIYVSGAKGGS-..........KSTEEGIHEASREDG......rKYaaVSYPYV..LTMALGEVVVTNGPDT..LGSLQKVPGLLP.K.....D.......FVWKTPYNITKLMTGGAELKYASAIFNFGALCILEERI....ASGL.PI.QDKRAAHFASGMLSGMAAAMVTHPINSLREYGLVQFRV.DNGRLHNVSTVKLCQELFYCFTS.DPKAALKSFGN.MSLKRVPINATLTGLIFAFVAGINETMGPEPLN----vf.
G9EIQ5_9GAMM/29-322                  ...WEFANFIVVAGTTSAAVIGVQSPVKTLLMN.LSKHN..TLL.PNTY.....SGGTL...SFFKALYAGTNT.SIKGSAARTAYVTSTKENKPt........eTVLNEGLIKEENIVEdg..ikpNH.rVSPGYV..ASAALGDTAVTQIPES..LSQLKKVPGLLP.A.....N.......FKWYTPYNAYKLMSNGFGFRYSAGLINFMCMLQFENEI....ARRL.PI.NDTVKKHSLAGALSGATAAFFAYPFAAYKDYLLAQTTVnNKGLLINARSSIVIKDIINNLTN.DPKKALLQVFD.NTKKQLPIRMALTATIFAIISGTEKILGPEPLTKIVP...
A0A6F8T413_9GAMM/27-311              ...WRFSNFTAVAGVTSFCIVAVQSPAKTFLVN.LTKNG..TAM.P-VY.....SGGTF...GFVRALYAGSTA.SLSGSLARTVYVTSAKNHKPv........eIMPEEMVRGEGKFTR.......--..ANLAFF..AAAAGGDVAVSQIPES..LSILKKVQGLLP.P.....D.......FKWFTANNAYQLMTGGFGAKYSSALINFTSLCMVEDVI....AQNL.PI.SEPKTRHFFAGALSGVVASVCSYPFTVIKDLTLVKSMVsPASQLSIPSTSSVIKDLIKDFKE.NPLQVAKAAVG.NSGKQLLVRAPLTAAIFGIISTVGAAMGPEPLKDFVP...
#=GC seq_cons                        ...aphsNhsshsushShulsslpsPhpslLsp.lppsu..ohh.s.sh.....suG.....shh+uhYtGhhu.uluGptttslhVTup+sN+...........hs.E-plcpphphpp.......pa....hGhl..hhushGDlhVoph.ps..hupLppsshlhs.s.....s.......FpW.ohtNhhpLhpsGassRhhuGhlNFuuLshlp-hI....upth..h.pccthp+hsuGAhSGshAuhhoaPhsuatDhhLlpopV.psG+Lhssoshohhpphtsphpp.ss+puhpsFht.shhKplPlRsshTullFuhlsGlschhGsEPLpclhP...
//