#=GF ID SUP10_C
#=GF AC PF29118.1
#=GF DE SUP-10 C-terminal domain
#=GF AU Morveli N;0000-0003-2496-881X
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE TED:Q17374_TED03
#=GF GA 27.00 27.00;
#=GF TC 27.00 27.20;
#=GF NC 25.90 25.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 8 -E 1000 -Z 90746521 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 14534247
#=GF RT sup-9, sup-10, and unc-93 may encode components of a two-pore K+
#=GF RT channel that coordinates muscle contraction in Caenorhabditis
#=GF RT elegans.
#=GF RA de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR;
#=GF RL J Neurosci. 2003;23:9133-9145.
#=GF RN [2]
#=GF RM 24586202
#=GF RT The Caenorhabditis elegans iodotyrosine deiodinase ortholog
#=GF RT SUP-18 functions through a conserved channel SC-box to regulate
#=GF RT the muscle two- pore domain potassium channel SUP-9.
#=GF RA de la Cruz I.P., Ma L., Horvitz H.R.;
#=GF RL PLoS Genet. 10:E1004175-E1004175(2014).
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This entry represents the C-terminal domain found in SUP-10
#=GF CC proteins, spanning approximately 125 amino acids. This domain is
#=GF CC found in nematodes within the Chromadorea class. SUP-10 is a
#=GF CC putative potassium channel regulatory protein that may
#=GF CC contribute to coordination of muscle contraction as a regulatory
#=GF CC subunit of a nonessential potassium channel complex [1]. SUP-10
#=GF CC may form a complex with SUP-9 and UNC-93 where SUP-10 and UNC-93
#=GF CC act as regulatory subunits of the two pore potassium channel
#=GF CC SUP-9 [1,2]. The protein localises to dense body-like structures
#=GF CC in body-wall muscle cells and colocalises with SUP-18. The
#=GF CC specific function of this domain within SUP-10 remains to be
#=GF CC determined
#=GF SQ 66
#=GS A0A914DK20_9BILA/57-85 AC A0A914DK20.1
#=GS W2U1N3_NECAM/173-201 AC W2U1N3.1
#=GS A0AAF3EPS5_9BILA/299-327 AC A0AAF3EPS5.1
#=GS A0A6V7WGH6_9BILA/338-366 AC A0A6V7WGH6.1
#=GS A0A914XEC4_9BILA/374-402 AC A0A914XEC4.1
#=GS A0A914GG43_9BILA/321-349 AC A0A914GG43.1
#=GS A0A1I7V7F2_LOALO/301-329 AC A0A1I7V7F2.1
#=GS A0A914M6K8_MELIC/340-368 AC A0A914M6K8.1
#=GS A0A9P1MJG4_9BILA/294-322 AC A0A9P1MJG4.1
#=GS A0A914IR05_9BILA/247-275 AC A0A914IR05.1
#=GS A0A0R3PPA9_ANGCS/224-252 AC A0A0R3PPA9.1
#=GS A0A077ZF58_TRITR/302-330 AC A0A077ZF58.1
#=GS A0A915PDJ3_9BILA/302-330 AC A0A915PDJ3.1
#=GS A0A914MVV0_MELIC/161-189 AC A0A914MVV0.1
#=GS A0A914U4U0_9BILA/410-438 AC A0A914U4U0.1
#=GS A0A261CRK2_9PELO/321-349 AC A0A261CRK2.1
#=GS A0AAD5R6Y5_PARTN/155-183 AC A0AAD5R6Y5.1
#=GS J9FAA0_WUCBA/302-330 AC J9FAA0.1
#=GS A0A183EJ13_9BILA/297-325 AC A0A183EJ13.1
#=GS A0A3P7PS86_DRAME/80-108 AC A0A3P7PS86.1
#=GS A0AAD5R6Q4_PARTN/98-126 AC A0AAD5R6Q4.1
#=GS A0A158RAM2_THECL/301-329 AC A0A158RAM2.1
#=GS A0A2G5SM11_9PELO/280-308 AC A0A2G5SM11.1
#=GS A0A016VSB6_9BILA/79-107 AC A0A016VSB6.1
#=GS A0A8S1H4F7_9PELO/336-364 AC A0A8S1H4F7.1
#=GS A0A914GTX8_GLORO/314-342 AC A0A914GTX8.1
#=GS SUP10_CAEEL/290-318 AC Q17374.2
#=GS A8WRG8_CAEBR/291-319 AC A8WRG8.2
#=GS A0A3P7SD77_HAEPC/244-272 AC A0A3P7SD77.1
#=GS A0A182EHJ6_ONCOC/298-326 AC A0A182EHJ6.1
#=GS A0A183J686_9BILA/284-312 AC A0A183J686.1
#=GS A0A368FWI9_ANCCA/190-218 AC A0A368FWI9.1
#=GS A0A8R1XZG9_ONCVO/298-326 AC A0A8R1XZG9.1
#=GS A0A6V7Y682_9BILA/290-318 AC A0A6V7Y682.1
#=GS A0A2G9UPL8_TELCI/234-262 AC A0A2G9UPL8.1
#=GS A0A2A2KMK2_9BILA/243-271 AC A0A2A2KMK2.1
#=GS A0AA36G4S0_9BILA/296-323 AC A0AA36G4S0.1
#=GS A0A0N4TS98_BRUPA/302-330 AC A0A0N4TS98.1
#=GS A0A0C2D7E1_9BILA/98-126 AC A0A0C2D7E1.1
#=GS A0A3P6T2C4_LITSI/304-332 AC A0A3P6T2C4.1
#=GS A0A7E4W4K3_PANRE/303-331 AC A0A7E4W4K3.1
#=GS A0A4E9EQF0_BRUMA/302-330 AC A0A4E9EQF0.1
#=GS A0A6V7XI93_9BILA/287-315 AC A0A6V7XI93.1
#=GS A0A8R1HUT0_CAEJA/263-291 AC A0A8R1HUT0.1
#=GS A0A914MI34_MELIC/339-367 AC A0A914MI34.1
#=GS A0A915DTX2_9BILA/417-445 AC A0A915DTX2.1
#=GS A0A9P1IYT4_9PELO/294-322 AC A0A9P1IYT4.1
#=GS A0A8S1ELX7_9PELO/291-319 AC A0A8S1ELX7.1
#=GS A0A914RFC1_PAREQ/76-104 AC A0A914RFC1.1
#=GS A0A0B1TS17_OESDE/256-284 AC A0A0B1TS17.1
#=GS A0A498SEY6_ACAVI/302-330 AC A0A498SEY6.1
#=GS A0A3P7IYJ1_STRVU/51-79 AC A0A3P7IYJ1.1
#=GS A0A915BDQ5_PARUN/319-347 AC A0A915BDQ5.1
#=GS A0A914YU54_9BILA/312-340 AC A0A914YU54.1
#=GS E3MMK6_CAERE/337-365 AC E3MMK6.1
#=GS A0A0R3R2W2_9BILA/302-330 AC A0A0R3R2W2.1
#=GS A0AA36HDZ2_CYLNA/101-129 AC A0AA36HDZ2.1
#=GS A0AAD4R6L8_9BILA/436-464 AC A0AAD4R6L8.1
#=GS A0A8J2Q5W7_9BILA/302-330 AC A0A8J2Q5W7.1
#=GS A0AAF3ENP1_9BILA/302-330 AC A0AAF3ENP1.1
#=GS A0A9P1AZA2_9PELO/694-722 AC A0A9P1AZA2.1
#=GS A0A0D8XJ72_DICVI/290-318 AC A0A0D8XJ72.1
#=GS A0A0M3JSV5_ANISI/191-219 AC A0A0M3JSV5.1
#=GS A0A0B2UMX3_TOXCA/297-325 AC A0A0B2UMX3.1
#=GS A0A811KJ24_9BILA/283-311 AC A0A811KJ24.1
#=GS A0A1I7SUG2_BURXY/287-315 AC A0A1I7SUG2.1
A0A914DK20_9BILA/57-85 ...ESAIKKLERNPTFIVVGAIGGIAVVALAM
W2U1N3_NECAM/173-201 ...EHDLVKLEHKQSYVLVGLTGGIAVIALAM
A0AAF3EPS5_9BILA/299-327 ...EVDLKKLEHKTAYIAVGLAGGIAVIALAI
A0A6V7WGH6_9BILA/338-366 ...ERHLKSIEQNRQYLAVGTIGGVAVMALAM
A0A914XEC4_9BILA/374-402 ...EGSIDRLKRKTSYVVIGATGGIAVILLAI
A0A914GG43_9BILA/321-349 ...ELYINGIVTNPTYIIVGLIGGIAVIALAI
A0A1I7V7F2_LOALO/301-329 ...NEQSLLLKSDPSYILVGATGGIAVVVLAI
A0A914M6K8_MELIC/340-368 ...ERHLKSIEQNRQYLAVGTIGGVAVMALAM
A0A9P1MJG4_9BILA/294-322 ...EHLLMELEHKISYVLIGVAGGCAVCTLAF
A0A914IR05_9BILA/247-275 ...ELSIREMESNPTYIVVGAIGGIAVIALAI
A0A0R3PPA9_ANGCS/224-252 ...EHDLVKLEHKQSYVLVGITGGVAVIALAI
A0A077ZF58_TRITR/302-330 ela---LASRMQRPLYIITGLTGGIGVIVLAV
A0A915PDJ3_9BILA/302-330 ...NEESTTLESEPSYILVGATGGIAVVALAI
A0A914MVV0_MELIC/161-189 ...ERHLKSIEQNRQYLAVGTIGGVAVMALAM
A0A914U4U0_9BILA/410-438 ...ELYINGIVTNPTYIIVGLIGGIAVIALAI
A0A261CRK2_9PELO/321-349 ...ELEISERNKRPTFILVGLTSGIAVIILAF
A0AAD5R6Y5_PARTN/155-183 ...EHDLVKLEHNQAYVLVGITGGVAVIALAI
J9FAA0_WUCBA/302-330 ...NEQSLLLESDSSYILVGATGGIAVVVLAI
A0A183EJ13_9BILA/297-325 ...HEQSSALESEPSYILVGATGGIAVVALAI
A0A3P7PS86_DRAME/80-108 ..q-RLSHEIEWRPSLITVGAIGGIAVVALAM
A0AAD5R6Q4_PARTN/98-126 ...EHDLVKLEHNQAYVLVGITGGVAVIALAI
A0A158RAM2_THECL/301-329 ...NEQASTLVSKPNYILVGATGGIAVVALAI
A0A2G5SM11_9PELO/280-308 ...ELEISERNKRPTFILVGLTGGIAVIILAF
A0A016VSB6_9BILA/79-107 ...EHDLVKLEHKQSYVLVGLTGGIAVIALAM
A0A8S1H4F7_9PELO/336-364 ...EQEIQIFNHRKSYVLVGLTGGVAVIALAM
A0A914GTX8_GLORO/314-342 ...ERILRAIERKREYLTVGIIGGVAVMALAM
SUP10_CAEEL/290-318 ...ELEISERNKRPAFVLVGLTGGIAVIILAF
A8WRG8_CAEBR/291-319 ...ELEISERNKRPTFILVGLTGGIAVIILAF
A0A3P7SD77_HAEPC/244-272 ...EHDLVKLEHKQSYVLVGLTGGIAVIALAM
A0A182EHJ6_ONCOC/298-326 ..n-KQSLILESEPSYILVGATGGIAVVALAI
A0A183J686_9BILA/284-312 ...EEDAMEVTSKSKFIIIGVTGGIGVIALAV
A0A368FWI9_ANCCA/190-218 ...EHDLVKLEHKQSYVLVGLTGGIAVIALAM
A0A8R1XZG9_ONCVO/298-326 ..n-KQSLILESEPSYILVGATGGIAVVALAI
A0A6V7Y682_9BILA/290-318 ...ERHLKSIEQNRQYLAVGTIGGVAVMALAM
A0A2G9UPL8_TELCI/234-262 ...EHDLVKLEHKQAYVLVGLTGGIAVIALAM
A0A2A2KMK2_9BILA/243-271 ...EIDLDKLTKRTSYVLVGLVGGVSVIILAI
A0AA36G4S0_9BILA/296-323 ..y--DLKKLEHKTSYIAVGLAGGIAVIALAI
A0A0N4TS98_BRUPA/302-330 ...NEQSLLLESDSSYILVGATGGIAVVVLAI
A0A0C2D7E1_9BILA/98-126 ...EHDLVKLEHKQSYVLVGLTGGIAVIALAM
A0A3P6T2C4_LITSI/304-332 ...NEQSLILESDPNYIVVGATGGIAVVVLAI
A0A7E4W4K3_PANRE/303-331 ...ELLIQRIEENPTYIVVGTVGGIAVIALAI
A0A4E9EQF0_BRUMA/302-330 ...NEQSLLLESDSSYILVGATGGIAVVVLAI
A0A6V7XI93_9BILA/287-315 ...ERHLKSIEQNRQYLAVGTIGGVAVMALAM
A0A8R1HUT0_CAEJA/263-291 ...ELEITERNKRPTFFLVGLTGGIAVIILAF
A0A914MI34_MELIC/339-367 ...ERHLRSIEQNRQYLAVGTIGGVAVMALAM
A0A915DTX2_9BILA/417-445 ...EISIKEIEYNRVYILVGTIGGIAVVALAI
A0A9P1IYT4_9PELO/294-322 ...EVESAKKNKRIEFILVGLTGGLAVIVLAY
A0A8S1ELX7_9PELO/291-319 ...ELEITERNKRPAFVLVGLAGGLAVIVLAY
A0A914RFC1_PAREQ/76-104 ...EDLSRKLEWKPVCIMVGATGGIAVVALAI
A0A0B1TS17_OESDE/256-284 ...EHDLVKLENKQSYVLVGLTGGIAVIALAV
A0A498SEY6_ACAVI/302-330 ..n-EKSLILESDPSYIVVGATGGIAVVVLAI
A0A3P7IYJ1_STRVU/51-79 ...EHDLVKLEHKQSYVLVGLTGGIAVIALAI
A0A915BDQ5_PARUN/319-347 ...EDLSRKLEWKPVCIMVGATGGIAVVALAI
A0A914YU54_9BILA/312-340 ...ELYINGIVTNPTYIIVGLIGGIAVIALAI
E3MMK6_CAERE/337-365 ...ELEISERNKRPTFILVGLTSGIAVIILAF
A0A0R3R2W2_9BILA/302-330 ...NEQSLLLESDSSYILVGATGGIAVVVLAI
A0AA36HDZ2_CYLNA/101-129 ...EHDLVKLENKQSYVLVGLTGGIAVIALAI
A0AAD4R6L8_9BILA/436-464 ...ELLIKNIETNRVFILVGTIGGIAVVALAI
A0A8J2Q5W7_9BILA/302-330 ...NEQSLILKSDPHYIVVGATGGIAVVVLAI
A0AAF3ENP1_9BILA/302-330 ...EVDLKKLEHKTAYIAVGLAGGIAVIALAI
A0A9P1AZA2_9PELO/694-722 ...ELEITERNKRPVFFLVGLTGGIAVIILAV
A0A0D8XJ72_DICVI/290-318 ...EHDLVKLEHKQSYVLVGVTGGVAVIALAI
A0A0M3JSV5_ANISI/191-219 ...ENLSKELEWKFGCIMVGTTGGIAVVALAI
A0A0B2UMX3_TOXCA/297-325 ...EDVSRELEWRPGCIMVGATGGIAVVALAI
A0A811KJ24_9BILA/283-311 ...ERSVQKIQENQVYVVVGAIGGIAVIALAI
A0A1I7SUG2_BURXY/287-315 ...ERSVQKIQDNQVYVVVGAIGGIAVIALAI
#=GC seq_cons ...EcpltclEpc.sYllVGhTGGIAVlALAl
//
