GenomeNet

Database: Pfam
Entry: Saf_2TM
LinkDB: Saf_2TM
Original site: Saf_2TM 
#=GF ID   Saf_2TM
#=GF AC   PF18303.4
#=GF DE   SAVED-fused 2TM effector domain
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Laks
#=GF GA   29.50 29.50;
#=GF TC   29.90 36.30;
#=GF NC   27.50 29.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   26590262
#=GF RT   Comparative genomic analyses reveal a vast, novel network of
#=GF RT   nucleotide-centric systems in biological conflicts, immunity and
#=GF RT   signaling.
#=GF RA   Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;
#=GF RL   Nucleic Acids Res. 2015;43:10633-10654.
#=GF DR   INTERPRO; IPR041167;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Predicted pore-forming effector domain directly fused to
#=GF CC   predicted SAVED sensor domain. Binding of a ligand via the SAVED
#=GF CC   sensor is predicted to activate the Saf-2TM and initiate a cell
#=GF CC   suicide response. Component of a class of conflict systems
#=GF CC   reliant on the production of second messenger nucleotide or
#=GF CC   nucleotide derivative [1].
#=GF SQ   23
#=GS A0A2U2DQC0_9RHIZ/3-152  AC A0A2U2DQC0.1
#=GS W4QZT7_BACA3/10-155     AC W4QZT7.1
#=GS A0A1G7I4J2_9PROT/3-155  AC A0A1G7I4J2.1
#=GS A0A2R7T6R6_9BURK/6-157  AC A0A2R7T6R6.1
#=GS J2GUT1_9SPHN/1-112      AC J2GUT1.1
#=GS A0A0Q6MFZ1_9RHIZ/8-160  AC A0A0Q6MFZ1.1
#=GS A0A0X8GNB7_9BURK/7-154  AC A0A0X8GNB7.1
#=GS A0A3N9U3C1_9VIBR/1-154  AC A0A3N9U3C1.1
#=GS A0A1V8MAM2_9GAMM/5-149  AC A0A1V8MAM2.1
#=GS F4GRJ5_PUSST/3-155      AC F4GRJ5.1
#=GS C5T076_ACIDE/4-152      AC C5T076.1
#=GS A0A285UUJ7_9RHIZ/3-155  AC A0A285UUJ7.1
#=GS A0A0S3EW60_9SPHN/2-149  AC A0A0S3EW60.1
#=GS D0Z5J0_PHODD/8-156      AC D0Z5J0.1
#=GS A0A4R2N595_9BURK/3-152  AC A0A4R2N595.1
#=GS A0A255Y394_9SPHN/2-149  AC A0A255Y394.1
#=GS A0A0Q8BVH6_9RHIZ/3-152  AC A0A0Q8BVH6.1
#=GS A0A0D8CXJ8_9GAMM/2-154  AC A0A0D8CXJ8.1
#=GS A0A327M1P5_9PROT/8-154  AC A0A327M1P5.1
#=GS A0A1I4RIV7_9PSED/1-146  AC A0A1I4RIV7.1
#=GS Q07GQ9_ROSDO/3-155      AC Q07GQ9.1
#=GS M4S6W7_9SPHN/2-149      AC M4S6W7.1
#=GS A0A6C0TP34_9PSED/4-150  AC A0A6C0TP34.1
A0A2U2DQC0_9RHIZ/3-152             ......r-ETIDWAFREFIRFLLRPKGFEVR..IAAGCVAVLVVLLGW.....NFVVKATAPEG.-YSIEV--GSTNaIPEWVQWPLVAIFSA..IFVFCVFMGWRRSTRENELRNRKKVIVIEGRGLREDDGSPLTEAVPA.DIVGNRIG.VLLDLRQR.KDGIVVDPEELL.........
W4QZT7_BACA3/10-155                ......v-ILVIGAIIFFRNMVIQKKEQGYAavLFTTGIVLITNAFGTf...fDNVMQILTMLQ.SNSVEDSLRIQE.SFSDVNYTSLFIGVV..LLLTG--WLFSRY-----IQNKMFILNINGYYDRRIEGHHNELSLSTfEFKEREVD.FVRLFKIN.----KMTPTLA-a........
A0A1G7I4J2_9PROT/3-155             .......KRHFDNFLTKLIDWWFRITAVERY..LIGTGVTLLIAIFGG.....MPLILELLRFI.LGAVPERIFHFEaELETIDVLIFGAALL..LIVVGIAFAIARFIREARAQSKLRNIVIEARGLRDDDGNPLADTVAK.HQKGTVVP.VLLDLRNR.LDGQVIAPDRAL.........
A0A2R7T6R6_9BURK/6-157             .....tn--LVWLFCSKLIEWAFRKRGIARA..LITAGVSLIVLTAGV.....NLVGKAVYRDG.ARSIDVSVSTTDaFPSWVYWGLLALGLL..LLLAGVGFAVSDAWRDARAAHRGRVVVVEVRGLHSSPDSPLEKA-SI.SAPGVRQS.VLVDFRPA.SEQELVTPEAAL.........
J2GUT1_9SPHN/1-112                 ......m---LNHFLRSLIDWVFRRRSVGAS..LIKVGVPLYALVLV-.....SLTIGVRVPTK.DGPVVFSWDTSG.GAAALSWGVFIVATV..IVLTGLLLVVRDV----RRENRDKVIVIEARGLRDWQGEPL------.--------.--------.------------g........
A0A0Q6MFZ1_9RHIZ/8-160             .......WNTLDFVVRSLVSWFVRARHAESW..IFRGAVAALVAIHGA.....NWVFKYSGTIG.GESGSIEFGTAGaVPDSILWIITVVCIA..LMLGSAVWAWIRYANEQKRLARKKVFVIEGRGLRDDDGSSLKSAVPE.SITGTRID.YMLDLRQR.KDGVIVEPEDLL.........
A0A0X8GNB7_9BURK/7-154             ......l-NRILNILQEFGVLYLRRTPAGM-..FMKYGVLLMLGGPLL.....NISVSSYFKDDkGNFIKASLNSSE.PIWWISAGCFALGFI..FTAIGGYLAWQNY----RIQQRKRIIAIEVRGLTQSVDSPLVAAIPI.LILGQREE.LLIDVRNL.VDGTPAQRQKAL.........
A0A3N9U3C1_9VIBR/1-154             ......m-SLFHSVVTKAADYFFRKRSPALI..VFRGGISLLTMTLLG.....NFAFNARYENT.HQAFSINIPSSD.LPISLLTVGFYCGVA..LVVIGLIWEIHRDVAERRKLSRQVVISLEERGLVNTSDSPLSTFIQL.QYKGKRVDpIVIDIRDSlANGAVNYPVP--al.......
A0A1V8MAM2_9GAMM/5-149             ....lvy---FKSAIWKFILWLMRPKNI---..IFTTGRLFLVTGFGGgalfsNFSIKH-LSDN.GNNIVVDFSSDQ.VPYLLQHGLWLLGFIgaLILIA-EIIYISL-----GRSRTLVIGIEHIGLKKRISTPLSA----.-FLGRAET.IPIDLTTCyENDKVSNPTKAL.........
F4GRJ5_PUSST/3-155                 .......WDTVDFVIRSAARWFFRIRNAENW..IFHGAIAVLIVIHGA.....NWIFKYSGPIF.GTPSSVEFGTVGsIPDGILWSVTAVCAL..LMIASPVWAWKRYVNEQKRLSRKKVFIIEGRGLRDDDGSPLKTAVPD.SIVGTQMD.YLLDLRQH.KDGRIVEPEDLL.........
C5T076_ACIDE/4-152                 ....lnw---LMGIGTQLVTWWVRPRNIGLG..MMRWCGMVLVAALSG.....GLLVQLQAGA-.--EYRFMFSTAEgTPAVILYAVSAVALL..GFIVGAVLAGHAHVQDAKVTQVSRVLVAELRGLVDTSDRPLTKAVPP.TLRGRIED.CLVDVRAQ.LSG---------apdvpaal.
A0A285UUJ7_9RHIZ/3-155             .......WNTLDFVVRSLVSWFVRARHAESW..IFRGAVAVLVAIHGA.....NWVFKYSGTIG.GESGSIEFGTAGaVPDSILWIITVVCIA..LMLGSAMWAWIRYANEQKRLARKKVFVIEGRGLRDDDGSSLKSAVPE.SITGTRID.YMLDLRQR.KDGVIVEPEDLL.........
A0A0S3EW60_9SPHN/2-149             .......KKHFDYFIRSWIDFIFLRPLPGMR..LIKWGVTLILATFA-.....GFALTVGIPTE.NGRIDVSFDSGAgIPAFVLALVLTLASL..MIIGGALWLIVDL----RRESRKQVLAIELRGLRDMSGQPLISAVPT.GIMDRRVS.LLLDIRQG.ADGVLLSPEQAL.........
D0Z5J0_PHODD/8-156                 .......MYRLLHWGDLLFKWYTRPKSK---..LFTIGKFLVVSGLSSi..glTTALKIAFITPeGYELTASFFEND.----TGIFILLISSC..FIIVGFFLIIYDALLTIKDSGKANNILVEHIALFKPLSSSFLSTVTK.-AKGKMRC.VKIDLSEYyRDGVLSEPSDAV.........
A0A4R2N595_9BURK/3-152             ....ltw---LKSLIDQLVSFVLRPRHLGVK..LLEVSTLVLLGLAG-.....GFAFELRGFAD.IEVLK--FSSGEgLPGYLVSLTAYMALV..TWVIGLAMVVSSFRRERTEADARRVLVVELRGLMDTSDRPLLSSLPR.TVVGRPID.CHIDVRQL.VSA---------kppqvqeal
A0A255Y394_9SPHN/2-149             .......KKHFDYFIRSWIDFIFLRPLPGMR..LIKWGVTLILSTFV-.....GFALTVGIPTE.NGRIDVSFDSGAgIPAFVLALVLTFASL..MIIGGALWLFVDL----RRESRKQVLAIELRGLRDISGQPLISALPT.GIMDRRVS.LLLDIRQG.ADGVLLSPEQAL.........
A0A0Q8BVH6_9RHIZ/3-152             .......KDTLDWALREFVRFLVRPRGFEGR..IAQGCVPILVALLGW.....DWFVKFAAPDG.---HSLELGSANtIPEWIQLPLIVLFST..IFTFCMLISWRRLVRDNELRNRKKVIVIEGRGLREDDGSPLTEAVPA.DIVGNRIG.VLLDLRQR.RDGIVVDPKELL.........
A0A0D8CXJ8_9GAMM/2-154             .......KKAISYFIEKAADWFFRKRSPALI..VLRVGGSILLATLVG.....SWALTLVYKDA.ERSLELGYQSSS.TAQLFFTIGFFVGIA..TIVWGAVWEYQRYRDESKRNAKKKTIVIEQRGLVDTSDSPLGEYVKR.NCSWLVDT.IVNDIRERiIDNVITRPDLAL.........
A0A327M1P5_9PROT/8-154             .....nq--LLRRAVAAFIEWRFRKRSASLA..LIGLGVSILVAALG-.....----GLAVRFR.SGDTEFEFGGGA.SF-ALSAVGLAVGAA..LVGLGTWLLLQDRREEREARERKRVLVVEQRGLQRRFSTALREALPR.ALVGQIVE.KVIDVTPYfRDGVLAEQAA--af.......
A0A1I4RIV7_9PSED/1-146             ......m---INYFLRSLIDWIFRRRSTGLT..LVRIGVPLLAVVLV-.....GLTIGVEIPTS.QGPLVLKWDSSG.STGVLSYGVFVIASL..IVLIGLGLIIRDI----REEGRKKVIVIEARGLRDWQGQPLASAVPW.SVPGRREQ.VIVDLRQGlVDGQIVSPDVAL.........
Q07GQ9_ROSDO/3-155                 .......KRLFESFATKAIDWWFRVSAIERF..LITTAVALLIAIFGG.....VPLIAELLRIA.IGAVPEGYLNAQgKIDAVAGWILGIGFL..MIVVGLGLAIARFAGDAKSRSKKRIVVIEGRGLRDDDGAPLEGTVGK.QVEGQVVP.VLLDLRRR.MDGKVIEPERAL.........
M4S6W7_9SPHN/2-149                 .......KKHFDYFVRSWIDFIFLRPLPGMR..LIKWGVTLILATFA-.....GFALTVGIPTE.NGRIDVSFDSGAgIPAFALALVLTLASL..MIIGGALWLFVDL----RRESRKQVIAIELRGLRDMSGQPLISAVPT.GIMNRRVS.LLLDIRQG.ADGVLLSPEQAL.........
A0A6C0TP34_9PSED/4-150             aqlmdsi--------FDLATLYFRRSPTGL-..LLSAGVTLMLGGPWL.....AAKLVFRKESDdGGYIVGEINTTE.AEWWVNAACLGVGAL..LIAVGLYFAWITF----QEQRRKLVIALELRGLSQTADSSIQRAIPS.LILGRRES.IFIDVRQL.VQGTTAQKQEAV.........
#=GC seq_cons                      .........hlchhlpphlcahhRt+ssuhh..lhpsGVslLlushuh.....shslphth.ss.stslshpasous.hsthl.hhlhsluhl..lllsGhhhhhtchh.p.+ppsRK+VllIEtRGL+-ssusPLtsAlPp.slhGpphs.lllDlRpt.hDGhlspPpphL.........
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