#=GF ID   SecM_small
#=GF AC   PF10818.14
#=GF DE   secA translation cis-regulator SecM, small type
#=GF PI   DUF2547;
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   PRODOM
#=GF GA   26.10 26.10;
#=GF TC   26.50 26.10;
#=GF NC   25.60 23.50;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   21635582
#=GF RT   The translational regulatory function of SecM requires the
#=GF RT   precise timing of membrane targeting.
#=GF RA   Yap MN, Bernstein HD;
#=GF RL   Mol Microbiol. 2011;81:540-553.
#=GF DR   INTERPRO; IPR020508;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   In E. coli, SecM encodes a presecretory protein that regulates
#=GF CC   secA expression at the translational level. SecM contains a
#=GF CC   C-terminal sequence motif that induces a transient translation
#=GF CC   arrest [1]. SecM signal peptide plays an essential role in this
#=GF CC   regulatory process by acting as a molecular timer that
#=GF CC   coordinates secM membrane targeting with the synthesis of the
#=GF CC   arrest motif [1].
#=GF SQ   36
#=GS A0A9Q6Z1Y4_HISSO/7-99    AC A0A9Q6Z1Y4.1
#=GS A0A4V2T224_9PAST/7-101   AC A0A4V2T224.1
#=GS Y908_HAEIN/7-98          AC P44073.1
#=GS A0A377IZX5_9PAST/7-102   AC A0A377IZX5.1
#=GS A0A2U0T5D3_9PAST/1-81    AC A0A2U0T5D3.1
#=GS A0A2M8RVP6_9PAST/7-101   AC A0A2M8RVP6.1
#=GS I3D6P3_9PAST/1-85        AC I3D6P3.1
#=GS A0A6H0T847_9PAST/9-102   AC A0A6H0T847.1
#=GS A0A0A3AQ56_9PAST/9-104   AC A0A0A3AQ56.1
#=GS A0A4R1KWH4_9PAST/7-99    AC A0A4R1KWH4.1
#=GS A0A1V3TT08_9PAST/9-105   AC A0A1V3TT08.1
#=GS A0A4R1G641_9PAST/18-110  AC A0A4R1G641.1
#=GS A0A379B629_9PAST/7-102   AC A0A379B629.1
#=GS A0A1A7P2A3_9PAST/10-106  AC A0A1A7P2A3.1
#=GS A0A379CCA3_9PAST/9-105   AC A0A379CCA3.1
#=GS A6VQX1_ACTSZ/7-100       AC A6VQX1.1
#=GS A0A448TT95_9PAST/5-96    AC A0A448TT95.1
#=GS A0A8D4LN65_9PAST/8-109   AC A0A8D4LN65.1
#=GS Q7VKT2_HAEDU/9-106       AC Q7VKT2.1
#=GS A0A447STE5_AVIVO/7-102   AC A0A447STE5.1
#=GS A3MYW0_ACTP2/12-107      AC A3MYW0.1
#=GS B8F3L7_GLAP5/9-105       AC B8F3L7.1
#=GS A0A1V3IQW4_9PAST/7-97    AC A0A1V3IQW4.1
#=GS A0A1T0B2I1_9PAST/7-100   AC A0A1T0B2I1.1
#=GS A0A4P7CHV0_9PAST/9-105   AC A0A4P7CHV0.1
#=GS A0A4R6VCV2_9PAST/7-103   AC A0A4R6VCV2.1
#=GS A0A0J5P867_9PAST/1-82    AC A0A0J5P867.1
#=GS A0A4V2SKB2_9PAST/9-110   AC A0A4V2SKB2.1
#=GS A0A369ZV51_9PAST/9-100   AC A0A369ZV51.1
#=GS Q9CLK6_PASMU/8-102       AC Q9CLK6.1
#=GS A0A4R2N0B7_9PAST/7-101   AC A0A4R2N0B7.1
#=GS A0A1T0ATN4_9PAST/9-105   AC A0A1T0ATN4.1
#=GS E6KZY5_9PAST/8-103       AC E6KZY5.1
#=GS A0A3N4W398_9PAST/9-106   AC A0A3N4W398.1
#=GS A0A011MKJ9_9PAST/10-105  AC A0A011MKJ9.1
#=GS A0A2M8S020_9PAST/6-98    AC A0A2M8S020.1
A0A9Q6Z1Y4_HISSO/7-99               ...KQYFWSQLLLSVIAFFTLP.VA.QDIAPQKIT...NDYPKTQ.........nVI.Q..QL.YYT...AS..NI..Q..QVQQ....QQLRQi...rHVVTE....SSI.PF..QF.VPLFLVGQ...F.SHL-...PPIRAGP-..
A0A4V2T224_9PAST/7-101              ...KHSLWSQILAGMIAIFLLP.AT.QPLENRTAA..eNTYQNEQ..........TL.Q..PQ.SLF...DR..VL..Q.fKQTQ....QT-QIq..syTQIAA....RQK.FL..QI.EPHFAAFL...I.NPL-...APIRAGPV..
Y908_HAEIN/7-98                     ...KPNFWSRLLLSIIAIFALP.NA.QSFENQNNT...ENYSSSV..........SI.Q..QA.LET...VK..VA..R..EVQR....QAIPQ....pSISRQ....TEK.QL..KI.QPHFFTEA...L.NIS-...APIRAGPL..
A0A377IZX5_9PAST/7-102              ...KPHFWSRLLFSVIAFFALP.VA.QELDTANTNmvgGNYQTE-..........TQ.S..IV.SET...LA..TV..R..ELRQ....GSLQP....hTSSHA....VER.MLtpRY.QSDVFFSF...L.PQH-...APIRAGPL..
A0A2U0T5D3_9PAST/1-81               ...-----------MIALLTLP.QV.QGVERAQTL..hLEYQNQS..........LQ.T..QA.AHS...VF..AQ..A..EQYP....QAKTV.....RPAQQ....SIK.FN..KI.SPHFVAKI...F.SPS-...APIRGSPL..
A0A2M8RVP6_9PAST/7-101              ...KQNFWSQFFLSLIAIFALP.AV.QGLDTPTIG..rENYPNEQr........qTQ.S..QA.QQT...VK..QT..R.qIVAP....QPELR.....GFSHP....VII.LA..QN.TPHFYGAR...Y.YVQ-...APIRAGP-h.
I3D6P3_9PAST/1-85                   ...-----------MIAMFALP.NV.QGIEYSEST..tENYQQQSh........hFQ.Q..QL.LKK...VA..LV..-..HQAI....APYSDv...qQRHIE....QVK.FS..KS.EPHLFVSS...LcEFS-...PPIRGSP-s.
A0A6H0T847_9PAST/9-102              ...KSAFWSQFVLGMVAIFALP.QA.LATAEREQT...VINQSVE..........CQ.Q..EA.VQF...N-..--..-..EIEQ....QLFLSq..qqEIAVD....VLP.QA..VE.FCKFSANLprlY.RFVS...HPIRAGPV..
A0A0A3AQ56_9PAST/9-104              ...KPHFWSQFLLGMLAIMSLP.VN.ASLSQNQPAy.dQAYQQSQ.........qLQ.Q..HK.PAS...SL..FY..Q..QQQR....QI-RLq...qQVIRE....LPH.YR..PV.IRLLISRQ...H.HEAV...PPIRAGP-y.
A0A4R1KWH4_9PAST/7-99               ...KHNFWSQLLVSMIAIFALP.DV.QVADRINEY..sQEYQNQS..........NQ.Q..QV.LRA...IY..QI..-..--KQ....QNLSL.....TYPAQptviAKK.FV..KF.TPHFMAKV...F.AEY-...APIRGSP-f.
A0A1V3TT08_9PAST/9-105              ...KSTFLSQILLGVLAIFALP.SV.YGATN----...ENDQASI..........VN.Q..QV.LTL...SDlsAV..TkaDIEQ....AHL-Lq..leKPHVN....AQK.QA..VV.FTEFFTPL...Y.AFESiaiPPIRAGP-h.
A0A4R1G641_9PAST/18-110             ...KSSFWPHLLLGMLALFLLP.TN.QEFEVVNDN...LETNYQP..........LQ.Q..VE.QSD...ID..IA..-..FVQQ....FSLVAd...wDILRD....FPK.LS..QN.LPHFYAKI...L.VRQ-...RPIRAGPVi.
A0A379B629_9PAST/7-102              ...KQNFWSQLLLSMIAIFALP.VAaQGLENHALG..gETCPNEQr........qAP.Q..QV.VNL...IV..LA..K..QTQR....ESGKQ....pLLPIK....LDI.LF..KK.EPHFNTSI...L.HDI-...APIRAGPL..
A0A1A7P2A3_9PAST/10-106             ..r-KTLWQRLLLSVLTLFFLPlHA.EQPEHLTTTp.lEANQTVA..........VN.Q..QQ.QFN...LHflLL..K..KVQQ....QTIVS.....RQKIN....VQP.VL..QVmQQHRLPQI...N.RYQ-...ISIRAGPT..
A0A379CCA3_9PAST/9-105              kst---RFSHLLLGIVAFCAFS.SV.YGSTNQSE-...-TKSISV..........QQ.T..TP.FYQ...LA..HQ..N..SVLR....QTLQHfy.psKTKFS....LGL.QA..VT.FIPFFVKK...Y.QHLEtkaNPIRAGPT..
A6VQX1_ACTSZ/7-100                  ...KRYFWSQLLFSMIAMFALP.QV.QQWQHAEAN..nPTYQNQS..........VQ.R..QI.ACV...AQ..NL..Q.qKQAQ....QQFWA.....VSPIE....SQK.LL..EF.RPHFSGAV...F.TFH-...APIRGSPRi.
A0A448TT95_9PAST/5-96               ...KSYFWSPLLIGLLAIFSLA.NS.HHDSQ-TGD...PVSVQTL..........MT.Q..LQ.KNS...VA..VQ..Q..QMAD....QQLPHhfthaNVDPK....FER.Y-..--.VLGQFSHF...F.FLS-...ILIRAGP-e.
A0A8D4LN65_9PAST/8-109              ...KQQFWSQLLLGMLAIFVFP.LH.TEHKLTETT..eVNYTFTYekrshrynllAE.N..LI.IST...QR..LI..-..KQQN....AKYRT....sNLSSL....NTQ.YF..QI.PIKIYTKF...I.KRQ-...YSIRAGP-f.
Q7VKT2_HAEDU/9-106                  ...KTPFWSQLVFGVMAILALP.EF.QTTVASES-...ENEQNTI..........IN.Q..AV.MQS...AL..SV..D..EVEQ....QALFVe..lkQIIHN....IAP.QA..VV.FYDFLTKC...Y.RFEVdyqPPIRAGP-fi
A0A447STE5_AVIVO/7-102              ..t-QHFWSQLLLSMIAIFALP.NA.QGVENAGLA..cENYSREQ..........RQmQ..QL.ACH...QR..VA..HkqIIQQ....QQKPS....kKSFVA....PKI.LT..KK.APHFVFPV...L.SAA-...TPIRAGPT..
A3MYW0_ACTP2/12-107                 ...KTPFWSQLVFGLVAIFALP.EI.QATLNRE--...-NEQNTV..........IN.Q..LV.TQY...TQ..VT..E..DGEQ....QTLFIae.rhLAQMN....TTS.QA..VV.FCKILTKS...Y.RFYGddnHPIRAGPI..
B8F3L7_GLAP5/9-105                  ...KPALISQFLLGIVAIFALP.TA.QPLANES--...ETLPTNQlvlrlsdfssVQ.K..VE.LEA...AH..LL..-..HLEQ....QPLVI.....-----....PTK.QA..VV.FCEFFAKS...Y.RLYQvsnPPIRAGPT..
A0A1V3IQW4_9PAST/7-97               ..p-PYFWSRLLLSVIAIFALP.NT.QSLENNRA-...ENCSSEI..........SI.Q..QV.LES...AK..VV..R..YVQRp.spQAFP-.....-ASYF....EKK.QP..DF.QPHFVVAV...L.NRQ-...APIRAGPL..
A0A1T0B2I1_9PAST/7-100              ...KHNFWSQLLLSMIAILALP.QV.QGLPNQTNVa.nEAHQKTQ..........TI.Q..QH.LIN...QQ..VL..-..-VKQ....IPLHN....pQFSQQ...aTQQ.KI..AT.ANPYFYSL...A.EANT...PPIRAGP-n.
A0A4P7CHV0_9PAST/9-105              ...KPAFLSQFLLGIVAIFALP.TV.QPLANES--...ETLPTNQlvlrlsdfssVQ.K..VE.LES...AH..LL..-..HLEQ....QPLII.....-----....PTK.QA..VV.FCEFFAKS...Y.RLYQvsnPPIRAGPT..
A0A4R6VCV2_9PAST/7-103              ...KQNFWSQLLISMIAIFALP.QV.QGNQPVQTN...ANYQTQSa.......yqIQ.R..QAlLAS...AS..SV..Q.kTIVR....QIRLS.....ESKLI....PAA.QN..KT.ETNFNGHQ...I.RFH-...TPIRAGP-fi
A0A0J5P867_9PAST/1-82               ...------------MAIFALP.HL.ANGHLH---...EDTQNSQ..........VF.A..PE.MIE...MD..SA..-..-EPE....QPYFVrf.dsPIIPF....QPL.QA..VM.FCEFFTAS...Y.RLIVspkPPIRAGPL..
A0A4V2SKB2_9PAST/9-110              ...KSAFLSQFVLSIVAVFAMS.PI.FSASSAAVQ...DRDSKTV..........AN.Q..RI.LSA...FN..EF..S..TVQKtecsQSVFLqf.tlSFQVI....LPQ.QM..GI.FCNFFAVT...N.RLYFv.nPPIRAGPV..
A0A369ZV51_9PAST/9-100              ..r-KPLLSQFLLGILAIFSLP.EI.QPIPESEQ-...-----TI..........LN.Q..PL.VQA...IT..AE..A..EQEQ....HLFLA....eSKPENv..aSEV.QA..VE.ITPFFAKA...F.HFDGdlnHPIRAGP-a.
Q9CLK6_PASMU/8-102                  ...KHNFWSRLLLSMIAIFALP.QS.QELSTPTGLp.hENHRSSQ.........lIQ.Q..QI.SHT...IA..IA..Q..HVQQ....QSYHL.....IVPPQ....NKP.YV..RQ.NQAFFASI...L.TYSL...PPIRAGPI..
A0A4R2N0B7_9PAST/7-101              ...KPHFWPQLFLSLIAIFALP.TV.SSLENQSVN..hNNLSNEQ..........-R.Q..TV.SYTagiAI..LV..K..QVQN....QKLQP.....NHSVV....ITKiLH..KI.EPHFFSVP...F.FRN-...TPIRAGP-y.
A0A1T0ATN4_9PAST/9-105              ...KTPFWSQLVFGLFAMLALP.HA.QPNSVAE--...-NEPKTV..........VN.Q..SV.SDY...VQ..TYfeQ..ESEQ....QTPFFt..alVQSFE....MPL.QA..VR.FSEISAKS...Y.RLYLhstPPIRAGP-s.
E6KZY5_9PAST/8-103                  ...KHNFWSRLLLGMLAIFVLP.AT.QELNYPAAVg.nENYQNTQ..........QQ.NapQI.LTA...VS..LL..Q..QTRQ....QQFQP....qHALPA....VEI.LS..QN.EPHFSRSP...F.IPH-...APIRAGPV..
A0A3N4W398_9PAST/9-106              ...KSAFWSQLLLGIVAILALP.IP.QLSNETENS...PIQQTLT..........LS.E..LV.AKA...QS..QS..-..-DET....QIYFFlq.dlFSLQV....VIK.QA..VT.FCQLFTSY...Y.HFDTlvnPPIRAGPVi.
A0A011MKJ9_9PAST/10-105             ...KTPFWSQLLLGMFAMLALP.EI.QAINPNE--...-SEQETV..........IN.Q..SV.VQY...AQ..SV..A..DAEQ....QSPFIve.qrNLLVE....IKP.QA..VI.FCEFFAKS...Y.RFDRqnvYPIRAGPV..
A0A2M8S020_9PAST/6-98               ...KHSFWSQLLLGMLAIFLLP.TS.QNVSIQTTTq.eSNYQRTQ..........AL.E..QA.QHD...TV..FA..E..PSAL....TPLQS.....SALAE....AEI.YP..EI.TPHFALNR...F.AIE-...TPIRAGPI..
#=GC seq_cons                       ...KpsFWSQLLLuhlAIFALP.ps.Qshpstpt....pshpsst..........hp.Q..ph.hps...sp..hh..p..phpp....Qshhh.....ph.hp....sph..s..th.hscFhsph...a.php....sPIRAGPh..
//