GenomeNet

Database: Pfam
Entry: Serinc
LinkDB: Serinc
Original site: Serinc 
#=GF ID   Serinc
#=GF AC   PF03348.18
#=GF DE   Serine incorporator (Serinc)
#=GF PI   TMS_TDE; 
#=GF AU   Mifsud W;0000-0002-9805-6461
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF SE   Pfam-B_3473 (release 6.5)
#=GF GA   24.00 24.00;
#=GF TC   24.10 24.10;
#=GF NC   23.90 23.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10559794
#=GF RT   The human TDE gene homologue: localization to 20q13.1-13.3 and
#=GF RT   variable expression in human tumor cell lines and tissue. 
#=GF RA   Bossolasco M, Lebel M, Lemieux N, Mes-Masson AM; 
#=GF RL   Mol Carcinog 1999;26:189-200.
#=GF RN   [2]
#=GF RM   10637174
#=GF RT   Identification of a ubiquitous family of membrane proteins and
#=GF RT   their expression in mouse brain. 
#=GF RA   Grossman TR, Luque JM, Nelson N; 
#=GF RL   J Exp Biol 2000;203:447-457.
#=GF RN   [3]
#=GF RM   16120614
#=GF RT   Serinc, an activity-regulated protein family, incorporates
#=GF RT   serine into membrane lipid synthesis. 
#=GF RA   Inuzuka M, Hayakawa M, Ingi T; 
#=GF RL   J Biol Chem. 2005;280:35776-35783.
#=GF DR   INTERPRO; IPR005016;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is a family of eukaryotic membrane proteins which
#=GF CC   incorporate serine into membranes and facilitate the synthesis
#=GF CC   of the serine-derived lipids phosphatidylserine and sphingolipid
#=GF CC   [3].  Members of this family contain 11 transmembrane domains
#=GF CC   and form intracellular complexes with key enzymes involved in
#=GF CC   serine and sphingolipid biosynthesis [3].
#=GF SQ   5561
#=GS A0A6A4W318_AMPAM/3-397      AC A0A6A4W318.1
#=GS A0A5J5CWA6_9PERO/207-380    AC A0A5J5CWA6.1
#=GS A0A0P7UXM3_SCLFO/15-457     AC A0A0P7UXM3.1
#=GS A0A1A0H9G7_9ASCO/16-470     AC A0A1A0H9G7.1
#=GS G5BUA6_HETGA/1-394          AC G5BUA6.1
#=GS A0A5A7SW70_CUCME/2-408      AC A0A5A7SW70.1
#=GS B9RWQ0_RICCO/296-370        AC B9RWQ0.1
#=GS A0A1Q3EMM5_LENED/220-387    AC A0A1Q3EMM5.1
#=GS A0A3P8SPJ6_AMPPE/15-456     AC A0A3P8SPJ6.1
#=GS A0A6P3XA66_DINQU/11-459     AC A0A6P3XA66.1
#=GS A0A2K6CAM7_MACNE/24-462     AC A0A2K6CAM7.1
#=GS G3MXF8_BOVIN/15-453         AC G3MXF8.1
#=GS A0A2I3RWG6_PANTR/11-417     AC A0A2I3RWG6.1
#=GS F6ZBF6_MOUSE/1-76           AC F6ZBF6.1
#=GS A0A250XPI8_9CHLO/1-302      AC A0A250XPI8.1
#=GS A0A0M3IZX9_ANISI/1-247      AC A0A0M3IZX9.1
#=GS A0A2K5EYC7_AOTNA/35-493     AC A0A2K5EYC7.1
#=GS A0A183KZH5_9TREM/1-64       AC A0A183KZH5.1
#=GS A0A1S4ABT3_TOBAC/16-318     AC A0A1S4ABT3.1
#=GS A0A3M6UUN0_POCDA/157-230    AC A0A3M6UUN0.1
#=GS A0A672ZRP6_9TELE/15-452     AC A0A672ZRP6.1
#=GS A0A7N9DE05_MACFA/1-277      AC A0A7N9DE05.1
#=GS A0A401RWU5_CHIPU/15-474     AC A0A401RWU5.1
#=GS A0A7N9APM4_9TELE/3-456      AC A0A7N9APM4.1
#=GS A0A099ZHG4_TINGU/3-450      AC A0A099ZHG4.1
#=GS F7D835_ORNAN/15-421         AC F7D835.2
#=GS A0A3Q7F704_SOLLC/26-323     AC A0A3Q7F704.1
#=GS A0A6A6MEZ5_HEVBR/1-315      AC A0A6A6MEZ5.1
#=GS G2R2Z6_THETT/23-494         AC G2R2Z6.1
#=GS A0A2K6LCJ3_RHIBE/1-220      AC A0A2K6LCJ3.1
#=GS A0A6P5CF47_BOSIN/11-455     AC A0A6P5CF47.1
#=GS A0A093JX40_STRCA/2-445      AC A0A093JX40.1
#=GS A0A2H2JBA9_CAEJA/15-443     AC A0A2H2JBA9.1
#=GS A0A6P3ET63_OCTDE/15-469     AC A0A6P3ET63.1
#=GS A0A162JHI3_CORFA/23-476     AC A0A162JHI3.1
#=GS A0A1B6Q1D1_SORBI/248-332    AC A0A1B6Q1D1.1
#=GS A0A315WB77_GAMAF/53-504     AC A0A315WB77.1
#=GS A0A0A0L9J6_CUCSA/348-435    AC A0A0A0L9J6.1
#=GS A0A3P9N2F9_POERE/11-456     AC A0A3P9N2F9.1
#=GS A0A3R7M259_TRYRA/312-397    AC A0A3R7M259.1
#=GS F4P5C1_BATDJ/13-457         AC F4P5C1.1
#=GS A0A1S2Y353_CICAR/82-390     AC A0A1S2Y353.2
#=GS D7LFR2_ARALL/36-331         AC D7LFR2.1
#=GS A0A1S3PBI2_SALSA/40-383     AC A0A1S3PBI2.1
#=GS A0A672H1D2_SALFA/7-444      AC A0A672H1D2.1
#=GS A0A397IGS5_9GLOM/21-460     AC A0A397IGS5.1
#=GS G1MHA6_AILME/24-460         AC G1MHA6.2
#=GS A0A6P5WH07_DURZI/8-411      AC A0A6P5WH07.1
#=GS A0A6G1G0K3_9PEZI/9-463      AC A0A6G1G0K3.1
#=GS A0A5C3E836_9BASI/214-269    AC A0A5C3E836.1
#=GS A0A498HYC0_MALDO/16-158     AC A0A498HYC0.1
#=GS A0A286ZRW1_PIG/15-403       AC A0A286ZRW1.2
#=GS Q494Q0_ARATH/2-406          AC Q494Q0.1
#=GS A0A2T3A2Y4_9PEZI/23-481     AC A0A2T3A2Y4.1
#=GS A0A4V4H3J4_MUSBA/8-413      AC A0A4V4H3J4.1
#=GS A0A068TTL0_COFCA/318-400    AC A0A068TTL0.1
#=GS A0A663MNQ2_ATHCN/3-247      AC A0A663MNQ2.1
#=GS A0A1B9FUR9_9TREE/26-502     AC A0A1B9FUR9.1
#=GS A0A663MNQ2_ATHCN/314-423    AC A0A663MNQ2.1
#=GS A0A135LHB3_PENPA/1-431      AC A0A135LHB3.1
#=GS M3ZSV6_XIPMA/46-487         AC M3ZSV6.1
#=GS A7S8Z8_NEMVE/3-265          AC A7S8Z8.1
#=GS A0A673N9F6_9TELE/16-453     AC A0A673N9F6.1
#=GS A0A4W5QLQ0_9TELE/12-454     AC A0A4W5QLQ0.1
#=GS A0A2R8M3X6_CALJA/11-457     AC A0A2R8M3X6.1
#=GS A0A1P8B544_ARATH/15-318     AC A0A1P8B544.1
#=GS A0A5E4QG35_9NEOP/67-149     AC A0A5E4QG35.1
#=GS K7N284_SOYBN/1-218          AC K7N284.1
#=GS A0A446MGQ3_TRITD/4-414      AC A0A446MGQ3.1
#=GS A0A2U9R3L2_PICKU/20-516     AC A0A2U9R3L2.1
#=GS A0A498HYC0_MALDO/154-354    AC A0A498HYC0.1
#=GS A0A445J9Y3_GLYSO/14-321     AC A0A445J9Y3.1
#=GS A0A2K5VS73_MACFA/15-470     AC A0A2K5VS73.2
#=GS A0A428NY17_9HYPO/23-472     AC A0A428NY17.1
#=GS A0A453E8X1_AEGTS/1-176      AC A0A453E8X1.1
#=GS A0A2P5W9V7_GOSBA/5-407      AC A0A2P5W9V7.1
#=GS A0A7E4VQI9_PANRE/15-441     AC A0A7E4VQI9.1
#=GS A0A0E0BY75_9ORYZ/179-320    AC A0A0E0BY75.1
#=GS A0A4W4GLL4_ELEEL/15-456     AC A0A4W4GLL4.1
#=GS W5N9X8_LEPOC/40-490         AC W5N9X8.1
#=GS A0A1A6HCH7_NEOLE/3-419      AC A0A1A6HCH7.1
#=GS A0A0E0BY69_9ORYZ/250-391    AC A0A0E0BY69.1
#=GS A0A2K6FBU7_PROCO/15-450     AC A0A2K6FBU7.1
#=GS A0A2G9NAV0_LITCT/25-467     AC A0A2G9NAV0.1
#=GS M2V1E9_COCH5/23-485         AC M2V1E9.1
#=GS A0A673MSC1_9TELE/15-443     AC A0A673MSC1.1
#=GS A0A6I9NDX2_9TELE/15-450     AC A0A6I9NDX2.1
#=GS A0A401TQN3_CHIPU/2-230      AC A0A401TQN3.1
#=GS A0A1X2IVI5_9FUNG/21-492     AC A0A1X2IVI5.1
#=GS A0A0L9VHU4_PHAAN/11-322     AC A0A0L9VHU4.1
#=GS A0A3B5Q8L0_XIPMA/1-233      AC A0A3B5Q8L0.1
#=GS A5DIX7_PICGU/20-473         AC A5DIX7.2
#=GS A0A5B8MYD9_9CHLO/5-301      AC A0A5B8MYD9.1
#=GS A0A1Z5RGY5_SORBI/9-209      AC A0A1Z5RGY5.1
#=GS A0A0D8Y0U2_DICVI/15-462     AC A0A0D8Y0U2.1
#=GS A0A6P7MJS3_BETSP/1-335      AC A0A6P7MJS3.1
#=GS A0A6P5L834_PHACI/11-457     AC A0A6P5L834.1
#=GS A0A453CDR0_AEGTS/5-154      AC A0A453CDR0.1
#=GS A0A6P4CMY2_ARADU/244-335    AC A0A6P4CMY2.1
#=GS A0A671T574_9TELE/15-451     AC A0A671T574.1
#=GS A0A199UES5_ANACO/302-384    AC A0A199UES5.1
#=GS A0A1A6HB86_NEOLE/15-473     AC A0A1A6HB86.1
#=GS A0A0C2J7G7_THEKT/12-425     AC A0A0C2J7G7.1
#=GS A0A6A3AZT8_HIBSY/8-411      AC A0A6A3AZT8.1
#=GS A0A2K5QNT9_CEBIM/6-441      AC A0A2K5QNT9.1
#=GS A0A0M0JSZ1_9EUKA/26-482     AC A0A0M0JSZ1.1
#=GS F4PVI0_CAVFA/16-417         AC F4PVI0.1
#=GS A0A093NP07_PYGAD/1-417      AC A0A093NP07.1
#=GS A0A3Q0GG78_ALLSI/1-421      AC A0A3Q0GG78.1
#=GS A0A091IL55_CALAN/3-450      AC A0A091IL55.1
#=GS A0A1Y1WHF5_9FUNG/13-462     AC A0A1Y1WHF5.1
#=GS A0A5J5EPF6_9PEZI/23-478     AC A0A5J5EPF6.1
#=GS A0A485N3L5_LYNPA/15-450     AC A0A485N3L5.1
#=GS A0A2G5DGD1_AQUCA/26-327     AC A0A2G5DGD1.1
#=GS L8WQT9_THACA/25-235         AC L8WQT9.1
#=GS A0A6I9MB08_PERMB/1-87       AC A0A6I9MB08.1
#=GS A0A059BX97_EUCGR/1-314      AC A0A059BX97.1
#=GS A0A015ING1_RHIIW/21-471     AC A0A015ING1.1
#=GS A0A4U5QDZ2_POPAL/36-332     AC A0A4U5QDZ2.1
#=GS A0A421J5I6_9ASCO/20-471     AC A0A421J5I6.1
#=GS A0A4V3XIX8_9APHY/25-489     AC A0A4V3XIX8.1
#=GS A0A673ZUM2_SALTR/59-501     AC A0A673ZUM2.1
#=GS A0A674I157_TERCA/18-448     AC A0A674I157.1
#=GS A0A1D6KQL3_MAIZE/1-336      AC A0A1D6KQL3.1
#=GS A0A0V0X036_9BILA/28-453     AC A0A0V0X036.1
#=GS A0A093H1G4_DRYPU/1-377      AC A0A093H1G4.1
#=GS A0A6J8B4P3_MYTCO/405-463    AC A0A6J8B4P3.1
#=GS A0A6P6D9F0_OCTDE/2-214      AC A0A6P6D9F0.1
#=GS A0A6P6BUC0_PTEVA/11-457     AC A0A6P6BUC0.1
#=GS G1PMB3_MYOLU/11-457         AC G1PMB3.1
#=GS A0A5N6JU34_9HELO/23-474     AC A0A5N6JU34.1
#=GS A0A368G7L8_ANCCA/2-253      AC A0A368G7L8.1
#=GS A0A2P5YRS0_GOSBA/26-321     AC A0A2P5YRS0.1
#=GS A0A4U5TVQ2_COLLU/55-499     AC A0A4U5TVQ2.1
#=GS A0A6F9D055_9TELE/15-485     AC A0A6F9D055.1
#=GS A0A5B6WH74_9ROSI/218-311    AC A0A5B6WH74.1
#=GS A0A091D5C7_FUKDA/15-450     AC A0A091D5C7.1
#=GS A0A672S5E6_SINGR/402-435    AC A0A672S5E6.1
#=GS A0A669D5S5_ORENI/15-435     AC A0A669D5S5.1
#=GS A0A6G1C089_9ORYZ/34-281     AC A0A6G1C089.1
#=GS A0A5A9PP46_9TELE/25-474     AC A0A5A9PP46.1
#=GS M5WS67_PRUPE/5-411          AC M5WS67.1
#=GS A0A2K6L2B5_RHIBE/35-285     AC A0A2K6L2B5.1
#=GS A0A674BN77_SALTR/11-476     AC A0A674BN77.1
#=GS A0A671L0I2_9TELE/11-456     AC A0A671L0I2.1
#=GS A0A399HU89_9PLEO/23-485     AC A0A399HU89.1
#=GS A0A5A8ED10_CAFRO/1-464      AC A0A5A8ED10.1
#=GS A0A6A4M312_9ERIC/110-322    AC A0A6A4M312.1
#=GS A0A667Z0G5_9TELE/15-440     AC A0A667Z0G5.1
#=GS A0A0V0RPH6_9BILA/18-443     AC A0A0V0RPH6.1
#=GS A0A6J0CEC2_NEOLC/11-439     AC A0A6J0CEC2.1
#=GS C3YMU1_BRAFL/18-480         AC C3YMU1.1
#=GS A0A6A4M8E6_9ERIC/103-227    AC A0A6A4M8E6.1
#=GS A0A671TTT6_SPAAU/15-456     AC A0A671TTT6.1
#=GS A0A3N0XTZ4_ANAGA/1-436      AC A0A3N0XTZ4.1
#=GS J3KWZ9_ORYBR/379-470        AC J3KWZ9.1
#=GS A0A2I0BH73_9ASPA/8-414      AC A0A2I0BH73.1
#=GS A0A5C6NAB8_9TELE/133-409    AC A0A5C6NAB8.1
#=GS M3X6Q6_FELCA/15-450         AC M3X6Q6.1
#=GS A0A6P8R049_GEOSA/15-458     AC A0A6P8R049.1
#=GS H0Z4A1_TAEGU/15-471         AC H0Z4A1.2
#=GS A0A183K852_9TREM/9-181      AC A0A183K852.1
#=GS A0A673BPM4_9TELE/315-413    AC A0A673BPM4.1
#=GS A0A6P5ZAG6_DURZI/310-386    AC A0A6P5ZAG6.1
#=GS A0A453CDS1_AEGTS/14-316     AC A0A453CDS1.1
#=GS A0A2K1JUL8_PHYPA/1-307      AC A0A2K1JUL8.1
#=GS A0A075B2S9_ROZAC/82-174     AC A0A075B2S9.1
#=GS A0A0L9VRR8_PHAAN/273-361    AC A0A0L9VRR8.1
#=GS A0A367IJ34_RHIST/1-288      AC A0A367IJ34.1
#=GS A0A667XVC0_9TELE/13-476     AC A0A667XVC0.1
#=GS A0A2K5KLY3_CERAT/1-242      AC A0A2K5KLY3.1
#=GS A0A0L7L6U5_9NEOP/1-42       AC A0A0L7L6U5.1
#=GS A0A6A2Z6M6_HIBSY/34-334     AC A0A6A2Z6M6.1
#=GS A0A446WPQ0_TRITD/97-328     AC A0A446WPQ0.1
#=GS A0A397YIC4_BRACM/25-405     AC A0A397YIC4.1
#=GS A0A672GIB7_SALFA/23-460     AC A0A672GIB7.1
#=GS A0A139AUA9_GONPJ/1-413      AC A0A139AUA9.1
#=GS A0A6G1C067_9ORYZ/15-310     AC A0A6G1C067.1
#=GS A0A665WKV7_ECHNA/1-426      AC A0A665WKV7.1
#=GS A0A507C9J9_9FUNG/1110-1213  AC A0A507C9J9.1
#=GS A0A059CWY5_EUCGR/314-396    AC A0A059CWY5.1
#=GS A0A446L7W6_TRITD/4-414      AC A0A446L7W6.1
#=GS A0A484CEJ7_PERFV/15-456     AC A0A484CEJ7.1
#=GS SERIC_MONBE/20-480          AC A9UY97.1
#=GS A0A674A5N0_SALTR/15-452     AC A0A674A5N0.1
#=GS A0A0P7X062_SCLFO/2-435      AC A0A0P7X062.1
#=GS F4RIM1_MELLP/29-505         AC F4RIM1.1
#=GS A0A2R6QV43_ACTCC/14-320     AC A0A2R6QV43.1
#=GS Q385C4_TRYB2/300-386        AC Q385C4.1
#=GS SERC3_HUMAN/15-470          AC Q13530.2
#=GS A0A6A2ZCZ4_HIBSY/225-381    AC A0A6A2ZCZ4.1
#=GS A0A6I9QTY6_ELAGV/17-323     AC A0A6I9QTY6.1
#=GS A0A445DXP9_ARAHY/11-319     AC A0A445DXP9.1
#=GS A0A6I9IWC3_CHRAS/35-481     AC A0A6I9IWC3.1
#=GS A0A553NKC9_9TELE/40-288     AC A0A553NKC9.1
#=GS A0A7I4F4G9_PHYPA/263-359    AC A0A7I4F4G9.1
#=GS A0A0S7DLU4_9EURO/23-485     AC A0A0S7DLU4.1
#=GS A0A212CBA9_CEREH/10-457     AC A0A212CBA9.1
#=GS W9YDS1_9EURO/23-478         AC W9YDS1.1
#=GS A0A1D6LS52_MAIZE/9-294      AC A0A1D6LS52.1
#=GS A0A672LM26_SINGR/6-153      AC A0A672LM26.1
#=GS S7RJ13_GLOTA/25-489         AC S7RJ13.1
#=GS A0A3Q1JTV1_ANATE/15-454     AC A0A3Q1JTV1.2
#=GS A0A0V1LL18_9BILA/28-233     AC A0A0V1LL18.1
#=GS Q7SAQ3_NEUCR/23-477         AC Q7SAQ3.1
#=GS A0A5J4ZW64_9ASTE/12-207     AC A0A5J4ZW64.1
#=GS A0A672ZZA7_9TELE/11-456     AC A0A672ZZA7.1
#=GS D6WM99_TRICA/14-459         AC D6WM99.1
#=GS A0A6A2ZCZ4_HIBSY/8-229      AC A0A6A2ZCZ4.1
#=GS A0A4Y9YQX7_9APHY/25-485     AC A0A4Y9YQX7.1
#=GS A0A2T7CJA6_9POAL/1-220      AC A0A2T7CJA6.1
#=GS A0A4S4LPG6_9AGAM/25-488     AC A0A4S4LPG6.1
#=GS L8YEH7_TUPCH/37-453         AC L8YEH7.1
#=GS A0A6J3HMD9_SAPAP/15-450     AC A0A6J3HMD9.1
#=GS A0A670JI79_PODMU/15-451     AC A0A670JI79.1
#=GS B0DAG8_LACBS/25-491         AC B0DAG8.1
#=GS Q28HX7_XENTR/15-445         AC Q28HX7.1
#=GS V7BLF0_PHAVU/322-410        AC V7BLF0.1
#=GS A0A6P6I012_PUMCO/15-450     AC A0A6P6I012.1
#=GS A0A0E0FH52_ORYNI/180-320    AC A0A0E0FH52.1
#=GS A0A6G1BZ81_9ORYZ/15-312     AC A0A6G1BZ81.1
#=GS W9CM21_SCLBF/23-474         AC W9CM21.1
#=GS A0A2K6CAP9_MACNE/15-453     AC A0A2K6CAP9.1
#=GS A0A6J0WKP5_ODOVR/1-397      AC A0A6J0WKP5.1
#=GS G0S656_CHATD/1-423          AC G0S656.1
#=GS W9J5G8_FUSOX/23-471         AC W9J5G8.1
#=GS A0A2N5SW59_9BASI/29-512     AC A0A2N5SW59.1
#=GS A0A1X2GYS5_SYNRA/153-459    AC A0A1X2GYS5.1
#=GS A0A2K5QNY9_CEBIM/14-449     AC A0A2K5QNY9.1
#=GS A0A6P5ZAE7_DURZI/19-322     AC A0A6P5ZAE7.1
#=GS A0A287IR11_HORVV/1-284      AC A0A287IR11.1
#=GS A0A670Y1J5_PSETE/11-457     AC A0A670Y1J5.1
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