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Database: Pfam
Entry: Sfi1_C
LinkDB: Sfi1_C
Original site: Sfi1_C 
#=GF ID   Sfi1_C
#=GF AC   PF10638.12
#=GF DE   Spindle body associated protein C-terminus  
#=GF AU   Wood V;0000-0001-6330-7526
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Wood V
#=GF GA   21.00 21.00;
#=GF TC   21.90 21.50;
#=GF NC   20.80 20.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   17392514
#=GF RT   Novel sfi1 alleles uncover additional functions for Sfi1p in
#=GF RT   bipolar spindle assembly and function. 
#=GF RA   Anderson VE, Prudden J, Prochnik S, Giddings TH Jr, Hardwick KG; 
#=GF RL   Mol Biol Cell. 2007;18:2047-2056.
#=GF DR   INTERPRO; IPR018907;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This C-terminal domain of spindle-body-associated protein Sfi1
#=GF CC   has an important role to play in the bridge-splitting during
#=GF CC   bi-polar spindle assembly, and this separation event possibly
#=GF CC   requires interaction with integral components of the nuclear
#=GF CC   envelope, such as the Mps2-Bbp1 complex [1]. Centrally to this
#=GF CC   domain is a region carrying centrin-binding repeats with
#=GF CC   repeating units containing tryptophan, family Sfi1_central,
#=GF CC   Pfam:PF08457.
#=GF SQ   31
#=GS A0A1G4M6V6_LACFM/819-925  AC A0A1G4M6V6.1
#=GS A0A7H9AWR8_ZYGMR/833-937  AC A0A7H9AWR8.1
#=GS SFI1_YEAST/809-914        AC Q12369.1
#=GS A7TFM1_VANPO/803-906      AC A7TFM1.1
#=GS G0V5H1_NAUCC/820-920      AC G0V5H1.1
#=GS A0A0C7MYA9_9SACH/825-928  AC A0A0C7MYA9.1
#=GS C5DCH5_LACTC/826-927      AC C5DCH5.1
#=GS G8BU12_TETPH/798-900      AC G8BU12.1
#=GS I2H870_TETBL/863-969      AC I2H870.1
#=GS A0A7H9HTK6_9SACH/809-921  AC A0A7H9HTK6.1
#=GS K0KX74_WICCF/894-1026     AC K0KX74.1
#=GS A0A1S7HJ85_9SACH/823-936  AC A0A1S7HJ85.1
#=GS J8Q587_SACAR/809-914      AC J8Q587.1
#=GS Q6FVT4_CANGA/762-857      AC Q6FVT4.1
#=GS A0A1S7H9B6_9SACH/823-936  AC A0A1S7H9B6.1
#=GS C5DRP6_ZYGRC/850-964      AC C5DRP6.1
#=GS G8JXI5_ERECY/831-939      AC G8JXI5.1
#=GS A0A1X7QYC4_9SACH/807-863  AC A0A1X7QYC4.1
#=GS A0A1E5R2E0_9ASCO/882-971  AC A0A1E5R2E0.1
#=GS G8ZVL3_TORDC/816-920      AC G8ZVL3.1
#=GS G0W7Z2_NAUDC/911-1011     AC G0W7Z2.1
#=GS J7S9R5_KAZNA/814-906      AC J7S9R5.1
#=GS A0A1V2L7P5_CYBFA/791-853  AC A0A1V2L7P5.1
#=GS Q75F87_ASHGO/838-946      AC Q75F87.1
#=GS A0A1E4S7Y9_CYBJN/815-880  AC A0A1E4S7Y9.1
#=GS A0A1E3NXD7_WICAA/882-976  AC A0A1E3NXD7.1
#=GS A0A376B9K1_9ASCO/830-919  AC A0A376B9K1.1
#=GS A0A1G4J835_9SACH/825-928  AC A0A1G4J835.1
#=GS Q6CK76_KLULA/822-924      AC Q6CK76.1
#=GS A0A1G4KGD1_9SACH/812-913  AC A0A1G4KGD1.1
#=GS H2ATD2_KAZAF/806-909      AC H2ATD2.1
A0A1G4M6V6_LACFM/819-925             .....................ee--AESLVTPTRVKPKD....QITIPGSEIIKKKRMEAM.RNHYRNAR.R..AIPSPVKSS..DTL...DSVSKRKLARNDIEG.SNFAGIsr.......spPPKMDLEKVNKKLATSRASISFKRIPE....................................................
A0A7H9AWR8_ZYGMR/833-937             .....................ap--SSNLVTPVRNTSSN....NNTIPGSEGVKKYRLEAM.KSHYSKVR.R..AIPSPVKSS..TTL...DSIAKKKFSRENENT.HWVAQPl.........pPPRISIERINKNLASKIDNINFERIPE....................................................
SFI1_YEAST/809-914                   .....................nl--KHELKTPIRSDSQN....ASTIPGSERIKQHRMEAM.KSHYSRAR.R..AIPSPVKSS..SVL...DSTAKKQINLESTTG.LNGSPTr........gkPLRYSPRRTTRNMPSKVDHIDFGRIP-a...................................................
A7TFM1_VANPO/803-906                 ......................m-DPAHLVTPMRDPPFA...eSQTIPGSELIKNYRIEAV.KFRYSRAK.R..LVPSPIKSS..VSL...GSSVKEKLQVSAASY.INERIS...........PPRLAIEKINKNLASKVHEIRFDKIPN....................................................
G0V5H1_NAUCC/820-920                 ...................ensp----NYQTPVKEPSDL....WTTIPGSERIKRSKMRAM.MDHYGKAR.R..AIPSPIKSS..SSL...NATARKRIETQKTAV.GIQWDRr........spSPRTRTSTRTNNVNSAIRK--------ssi.................................................
A0A0C7MYA9_9SACH/825-928             ....................gdm---QGLITPTRIRNSG....RITIPGSEQMKQNRMEAM.RNHYRKAR.K..AIPSPIRFS..ERL...DTVTKRRLEANAYAL.EQGSIS..........pPPKMDLEKINRKLASRKPAISFKSIPE....................................................
C5DCH5_LACTC/826-927                 ......................v-EDQSLVTPTRIKKSG....NITIPGSERMKQNRMEAM.RNHYRRAR.K..AIPSPIKFS..DNL...DTITKKRLEIGDRES.SEPSP-...........PPKLDLGKINKKLASRHTKISFKTIPE....................................................
G8BU12_TETPH/798-900                 ......................n-EVDRLETPKKSINTS....GNTIPGSELVKNYKVEAM.KSRYSRVR.H..SIPSPIKNS..STI...GSTIKRRFNQRNLNV.SPFPAS...........PPKLNLYRRYNISDNKNLEIDFNELP-y...................................................
I2H870_TETBL/863-969                 esspkklrllrntefstskvksp------ETPLKSML--....-ETIPGSSNIKRNRFDAF.KSRYGGVR.R..AIPSPQKKS..SLT...QTV-LNR--------.------...........---------------------------tdtpkiflsshtkenilstpnlpsenistpkv....................
A0A7H9HTK6_9SACH/809-921             .............snrvrqqipa--ESGLVTPIRRSATK....NNTIPGSEGVKRYRIEAM.KSHYGRIR.R..AIPSPIKSS..TTL...NSIAKKKINSEVDAF.TWSTRTi.........pPPRLSLERINKNLASKIDRINFERIPE....................................................
K0KX74_WICCF/894-1026                ..................nksis-----NSTPINNNENSi.isNSIIPGSEKIKRQRMEAL.KNHYSQIK.Y..AIPSPLKSEikNPL...STSTVKKLNFNKQDE.NDDEYD...........---------------------------dvdvnneeknqfyfndesidnfenqisspvishkkinqnflkrynslnkskt
A0A1S7HJ85_9SACH/823-936             .....................lq--NVELKTPTRRLSPK...gTNTIPGSEGVKMHRIEAM.KSHYSRVR.R..AIPSPIKSS..LSL...NSAVKKKIETEENVF.FATRAEqrqqq.hqqrpPPRLSLEKINRNLASKIDRINFERIPE....................................................
J8Q587_SACAR/809-914                 .....................dl--KRELKTPIRSDPLS....ASTIPGSERIKQHRMEAM.KSHYSRAR.R..AIPSPVKSS..SVL...DSTAKKQIKIEGATD.LNGSPTr........vrPIKYSPRRANRNLPSRVDHIDFGRIP-a...................................................
Q6FVT4_CANGA/762-857                 .............sdeldtaykt----------------....----PHRENVRKYDVLNFsDAKYRQAM.RtkKIASPIKAS..SVL...ESVLKRRVDNPYKLT.DENATQ...........MTIENGKEQMKKIESSISKLAFSDVP-q...................................................
A0A1S7H9B6_9SACH/823-936             .....................lq--NVELKTPTRRISPK...gTNTIPGSEGVKMHRIEAM.KSHYSRVR.R..AIPSPIKSS..LSL...NSAVKKKIETEDNVF.FTTRAEqhqhq.hqqrpPPRLSLEKINRNLASKIDRINFERIPE....................................................
C5DRP6_ZYGRC/850-964                 ......................q-QDFEVKTPIKKLSPK...gSNTIPGSEGVKMHRIEAM.KSHYSRVR.R..AIPSPVKSS..LSL...NSTAKKKIENEEDNV.FFSSKQkqqqqnqrlppPPRLSLERINKNLASKIDRINFERIPE....................................................
G8JXI5_ERECY/831-939                 .....................dv--SSGFMTPLKLDR--....-ITIPGSERMMKNKMERI.KNRYRGAR.R..AIPSPIKSS..NVL...GSSIKRKLSTMVNTN.QPHDDAyedd..htmtpVPKLNILQEGKKYNSSVKNLDFSRIPE....................................................
A0A1X7QYC4_9SACH/807-863             ...................qniq----GTQTPQRVPPQN....QDTIRGSSKVRKYKMDAR.ISHYRRAG.K..AIPSPIKD-..---...---------------.------...........---------------------------eigesr..............................................
A0A1E5R2E0_9ASCO/882-971             ....snnxepvfsnkqavdsksa----------------....------KDRMMQLSFSAR.KNRYRRTI.-..SRPSPIKET..LVL...SSAIKQRLMASQYET.------...........---------------------------pgntfptemgpratrsnqqkkprl............................
G8ZVL3_TORDC/816-920                 ......................s-EGMELVTPVRRNVPR....KNTIPGSEGVKRYRLEAM.KSHYGRVR.R..AIPSPVKSS..ATL...NSTAKRKIESEQEST.AWSPKPl.........fPPRLSLERINKNLASKIDTINFERIPE....................................................
G0W7Z2_NAUDC/911-1011                ...................ngtp----NFKTPRKSIMGT....SSTIPGSERMKDSKMKAM.MNHYSKAR.R..AIPSPLKTS..SSL...NLSARKKIEGRSWE-.------...........---------------------------grspsptihmgnsntndqrvirnnsislgdia....................
J7S9R5_KAZNA/814-906                 ....................tgn---NTLKTPMRKPD--....DSTFPGSTDIRRHKMAET.ISRYRKAR.R..AIPSPLKSS..TSL...TTPTKRMFQQRGLRG.PTDSTP..........rPPKLDFG--------------------nlqplrpdstr.........................................
A0A1V2L7P5_CYBFA/791-853             ....qtpqkavldpysipaltmt----------------....RGSIPGSERIKRKRMEAL.KTRYSQAK.F..AIPSPLKDQ..R--...---------------.------...........---------------------------tpasgri.............................................
Q75F87_ASHGO/838-946                 .....................si--SHDFMTPLKADK--....-VTIPGSERVKKNKMERI.KNRYRGAR.R..AIPSPIKSS..DIL...DSTTKRKLSKIGKIQ.TPLQNAyvdd..pnttpIPKLKLEQEGRRYSLRVRNIDFNRIPE....................................................
A0A1E4S7Y9_CYBJN/815-880             ..........rdpletssllysg---------------G....RSTMPGSERIRRKRMEAL.KVRYSQVK.K..AIPSPLKKD..RKL...DDSF-----------.------...........---------------------------lstlwknde...........................................
A0A1E3NXD7_WICAA/882-976             ...............ksplafgt------------NKKT....TTSIPGSERIKRKRIEAL.KSHYSQIK.Y..AIPSPLKSE..RKIinnSSQSSKRLDFTQHT-.------...........---------------------------prnqffqtqfnqrnsnnfqygaeldds.........................
A0A376B9K1_9ASCO/830-919             ....................pre----YFETPTKPRSRT....TSSIPMSERIKQTRMSAM.KNRYKKASlR..AIPSPIKSS..SVL...NSTIKNKFSPIKNRSpTRLQKS...........---------------------------dtflninsvrlrp.......................................
A0A1G4J835_9SACH/825-928             .....................pn--DRSLVTPTRMKKSG....RITIPGSEVIKRNRMEAM.KNHYRRAR.K..AIPSPIKFS..DNL...DSVTKRRLETNSETM.EDRATP..........pPPKMNLEKINKNLASKKSMINFRSIPE....................................................
Q6CK76_KLULA/822-924                 ......................n-DELTFQTPMKSPNNA....AVTIPGSTRVKRNKMDRI.RNRFSRAR.G..AIPSPIKTT..NVL...DSTVKARLSDQRNTA.AKDTTG...........AQATYLLSVNKRLAGKTRNISFNKIPE....................................................
A0A1G4KGD1_9SACH/812-913             .....................st--THHLTTPSRYRE-T....NQPVPDSELIKRNRMEAM.KTQYQRAR.R..AIPSPIKSS..ESL...NKSAKKRLTSSTEDS.GQKFPS...........PPKLDLNKVNSRLANKGEHISFKAIP-k...................................................
H2ATD2_KAZAF/806-909                 .....................tk--QTSLQTPHRPITPNssddVTTIPGSTAVRRTRMEAM.MSHYSKARrR..AIPSPLKSS..NAL...DTTVKRKLNSVEGNF.KPLRL-...........---------------------------dfgnlealkpsndrparsrrevtl............................
#=GC seq_cons                        ......................s....ph.TPh+..p.t....psTIPGSEplK+pRMEAh.Ks+Yu+AR.R..AIPSPlKSS..ssL...sSssK++lptppts.....t.............s.+hph.p..pphssph.tltFttlP.....................................................
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