GenomeNet

Database: Pfam
Entry: Spectrin
LinkDB: Spectrin
Original site: Spectrin 
#=GF ID   Spectrin
#=GF AC   PF00435.24
#=GF DE   Spectrin repeat
#=GF PI   spectrin; 
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Stabach P;
#=GF SE   Pfam-B_1 (release 1.0)
#=GF GA   29.90 24.20;
#=GF TC   29.90 24.20;
#=GF NC   29.80 24.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Spectrin_repeat
#=GF RN   [1]
#=GF RM   7584474
#=GF RT   Actin-binding proteins. 1: Spectrin super family. 
#=GF RA   Hartwig JH; 
#=GF RL   Protein Profile 1995;2:732-732.
#=GF RN   [2]
#=GF RM   8266097
#=GF RT   Crystal structure of the repetitive segments of spectrin. 
#=GF RA   Yan Y, Winograd E, Viel A, Cronin T, Harrison SC, Branton D; 
#=GF RL   Science 1993;262:2027-2030.
#=GF DR   INTERPRO; IPR002017;
#=GF DR   PROSITE; PDOC50083;
#=GF DR   SCOP; 1aj3; fa;
#=GF DR   HOMSTRAD; SPEC;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Spectrin repeat-domains are found in several proteins involved
#=GF CC   in cytoskeletal structure.  These include spectrin,
#=GF CC   alpha-actinin and dystrophin.  The sequence repeat used in this
#=GF CC   family is taken from the structural repeat in reference [2]. The
#=GF CC   spectrin domain- repeat forms a three helix bundle. The second
#=GF CC   helix is interrupted by proline in some sequences. The repeats
#=GF CC   are defined by a characteristic tryptophan (W) residue at
#=GF CC   position 17 in helix A and a leucine (L) at 2 residues from the
#=GF CC   carboxyl end of helix C. Although the domain occurs in multiple
#=GF CC   repeats along sequences, the domains are actually stable on
#=GF CC   their own - ie they act, biophysically, like domains rather than
#=GF CC   repeats that along function when aggregated.
#=GF SQ   181267
#=GS A0A674DIQ1_SALTR/409-514      AC A0A674DIQ1.1
#=GS B7YZG3_DROME/1074-1183        AC B7YZG3.1
#=GS A0A0M8ZZZ8_9HYME/1167-1271    AC A0A0M8ZZZ8.1
#=GS A0A2K6Q0J9_RHIRO/1899-2002    AC A0A2K6Q0J9.1
#=GS A0A7I2V4Y4_HUMAN/638-741      AC A0A7I2V4Y4.1
#=GS A0A6J2TT47_DROLE/298-408      AC A0A6J2TT47.1
#=GS A0A1Y9IGT0_ANOGA/6652-6758    AC A0A1Y9IGT0.1
#=GS F7HJP2_MACMU/899-985          AC F7HJP2.3
#=GS A0A672VG03_STRHB/5943-6049    AC A0A672VG03.1
#=GS A0A667ZTX1_9TELE/847-951      AC A0A667ZTX1.1
#=GS A0A3Q1JL06_ANATE/1945-2042    AC A0A3Q1JL06.2
#=GS A0A7E6D730_9CHIR/920-1033     AC A0A7E6D730.1
#=GS A0A452I8R1_9SAUR/509-615      AC A0A452I8R1.1
#=GS A0A6J1RH75_9HYME/579-675      AC A0A6J1RH75.1
#=GS A0A7F8RWG4_LEPWE/1444-1550    AC A0A7F8RWG4.1
#=GS A0A2H2IER7_CAEJA/81-189       AC A0A2H2IER7.1
#=GS A0A7M7L3E6_APIME/5914-6020    AC A0A7M7L3E6.1
#=GS A0A6J2WEH8_CHACN/3279-3383    AC A0A6J2WEH8.1
#=GS A0A5J4P2W7_9TREM/162-266      AC A0A5J4P2W7.1
#=GS A0A4W5P654_9TELE/736-838      AC A0A4W5P654.1
#=GS A0A6J1Z8H5_ACIJB/2269-2371    AC A0A6J1Z8H5.1
#=GS A0A673MBT5_9TELE/4351-4457    AC A0A673MBT5.1
#=GS A0A1S3SZ43_SALSA/1591-1695    AC A0A1S3SZ43.1
#=GS A0A7E6DGR1_9CHIR/796-900      AC A0A7E6DGR1.1
#=GS A0A3P9D1E4_9CICH/519-630      AC A0A3P9D1E4.1
#=GS A0A7R5K4Q5_9PASS/4144-4254    AC A0A7R5K4Q5.1
#=GS A0A6P9BE80_PANGU/4711-4818    AC A0A6P9BE80.1
#=GS A0A0V1M9N7_9BILA/3730-3836    AC A0A0V1M9N7.1
#=GS A0A4X2KHB0_VOMUR/1009-1115    AC A0A4X2KHB0.1
#=GS A0A674CUP7_SALTR/671-781      AC A0A674CUP7.1
#=GS A0A1S3KXH4_SALSA/2218-2323    AC A0A1S3KXH4.1
#=GS A0A6P7Q6R7_BETSP/5788-5883    AC A0A6P7Q6R7.1
#=GS A0A401RFM5_CHIPU/90-192       AC A0A401RFM5.1
#=GS A0A3Q7N240_CALUR/2665-2772    AC A0A3Q7N240.1
#=GS A0A6J2UGX6_DROLE/7022-7129    AC A0A6J2UGX6.1
#=GS A0A7N4PIH4_SARHA/973-1064     AC A0A7N4PIH4.1
#=GS A0A6J8DWR6_MYTCO/600-703      AC A0A6J8DWR6.1
#=GS A0A6P4J2J1_DROKI/4235-4342    AC A0A6P4J2J1.1
#=GS A0A067R9E8_ZOONE/566-668      AC A0A067R9E8.1
#=GS G3R7J8_GORGO/1380-1485        AC G3R7J8.2
#=GS Q29EZ8_DROPS/1074-1179        AC Q29EZ8.1
#=GS A0A6P6D9X6_OCTDE/4894-5001    AC A0A6P6D9X6.1
#=GS L9JBB2_TUPCH/1434-1541        AC L9JBB2.1
#=GS A0A6J2JPE6_BOMMA/3191-3296    AC A0A6J2JPE6.1
#=GS A0A0V0U169_9BILA/2300-2407    AC A0A0V0U169.1
#=GS A0A3S2NX91_CHISP/2017-2107    AC A0A3S2NX91.1
#=GS A0A2Y9M7W3_DELLE/2591-2697    AC A0A2Y9M7W3.1
#=GS A0A2K6RG57_RHIRO/1875-1979    AC A0A2K6RG57.1
#=GS A0A667YW67_9TELE/307-415      AC A0A667YW67.1
#=GS A0A6A5DZ13_PERFL/658-760      AC A0A6A5DZ13.1
#=GS A0A671N5A3_9TELE/33-138       AC A0A671N5A3.1
#=GS A0A3Q0DVL1_CARSF/519-632      AC A0A3Q0DVL1.1
#=GS A0A6P8WXS9_DROAB/656-760      AC A0A6P8WXS9.1
#=GS G1STR7_RABIT/1974-2078        AC G1STR7.3
#=GS A0A3Q1CZS7_AMPOC/439-547      AC A0A3Q1CZS7.1
#=GS T1ELU5_HELRO/1497-1602        AC T1ELU5.1
#=GS A0A673NGX6_9TELE/180-283      AC A0A673NGX6.1
#=GS F7HLQ1_MACMU/2210-2309        AC F7HLQ1.3
#=GS A0A0P8XRF6_DROAN/7784-7890    AC A0A0P8XRF6.1
#=GS A0A6P9BCZ5_PANGU/5998-6104    AC A0A6P9BCZ5.1
#=GS A0A6P5IJN3_PHACI/2076-2180    AC A0A6P5IJN3.1
#=GS A0A6J3CR76_AYTFU/284-394      AC A0A6J3CR76.1
#=GS A0A3Q1NKL1_BOVIN/796-900      AC A0A3Q1NKL1.1
#=GS A0A6P4ZD54_BRABE/1607-1713    AC A0A6P4ZD54.1
#=GS A0A667Z651_9TELE/1927-2030    AC A0A667Z651.1
#=GS A0A6I8THL0_AEDAE/4549-4656    AC A0A6I8THL0.1
#=GS A0A6P6D8R1_OCTDE/44-147       AC A0A6P6D8R1.1
#=GS A0A6J3I7T2_SAPAP/641-745      AC A0A6J3I7T2.1
#=GS A0A4S2LQP2_OPIFE/306-416      AC A0A4S2LQP2.1
#=GS A0A437C4J4_ORYJA/52-162       AC A0A437C4J4.1
#=GS A0A287AHQ7_PIG/6126-6236      AC A0A287AHQ7.2
#=GS A0A5E4N784_9HEMI/2022-2123    AC A0A5E4N784.1
#=GS A0A6P3YB47_DINQU/3246-3350    AC A0A6P3YB47.1
#=GS A0A2R9AQK4_PANPA/239-349      AC A0A2R9AQK4.1
#=GS A0A6Q2XA37_ESOLU/337-443      AC A0A6Q2XA37.1
#=GS A0A485N5Z0_LYNPA/596-700      AC A0A485N5Z0.1
#=GS A0A2K6E110_MACNE/1688-1793    AC A0A2K6E110.1
#=GS L9LBP3_TUPCH/309-387          AC L9LBP3.1
#=GS A0A6P9BMG6_PANGU/5148-5256    AC A0A6P9BMG6.1
#=GS A0A2K5YJ69_MANLE/273-383      AC A0A2K5YJ69.1
#=GS B4J2I5_DROGR/2060-2164        AC B4J2I5.1
#=GS A0A7E6DMI0_9CHIR/6347-6450    AC A0A7E6DMI0.1
#=GS A0A4W6E0N1_LATCA/641-745      AC A0A4W6E0N1.1
#=GS A0A672FBI6_SALFA/1508-1612    AC A0A672FBI6.1
#=GS A0A0V0U161_9BILA/1247-1350    AC A0A0V0U161.1
#=GS A0A2I3H911_NOMLE/40-151       AC A0A2I3H911.1
#=GS A0A455BL57_PHYMC/907-1011     AC A0A455BL57.1
#=GS A0A7M7MX18_APIME/2546-2645    AC A0A7M7MX18.1
#=GS A0A663NC38_ATHCN/6893-6999    AC A0A663NC38.1
#=GS A0A4W3JI48_CALMI/301-405      AC A0A4W3JI48.1
#=GS A0A3Q0D9W0_MESAU/3308-3414    AC A0A3Q0D9W0.1
#=GS A0A4W5RSU6_9TELE/1736-1840    AC A0A4W5RSU6.1
#=GS A0A671PU66_9TELE/3265-3386    AC A0A671PU66.1
#=GS A0A6J2JLZ8_BOMMA/4115-4222    AC A0A6J2JLZ8.1
#=GS A0A6Q2ZGK3_ESOLU/490-598      AC A0A6Q2ZGK3.1
#=GS A0A6P6D7H1_OCTDE/255-359      AC A0A6P6D7H1.1
#=GS A0A5N4BYF3_CAMDR/645-748      AC A0A5N4BYF3.1
#=GS A0A6J2UKG8_DROLE/8123-8229    AC A0A6J2UKG8.1
#=GS A0A2Y9QUW9_TRIMA/1070-1175    AC A0A2Y9QUW9.1
#=GS A0A1D5PV03_CHICK/3335-3441    AC A0A1D5PV03.2
#=GS A0A671DYT2_RHIFE/4145-4252    AC A0A671DYT2.1
#=GS A0A6I9MBE2_PERMB/1714-1818    AC A0A6I9MBE2.1
#=GS A0A2K6Q9X8_RHIRO/884-988      AC A0A2K6Q9X8.1
#=GS A0A340YG09_LIPVE/1643-1747    AC A0A340YG09.1
#=GS A0A6J1Z7W2_ACIJB/5576-5682    AC A0A6J1Z7W2.1
#=GS A0A672V5I9_STRHB/1677-1782    AC A0A672V5I9.1
#=GS A0A6P8ZW83_THRPL/4401-4507    AC A0A6P8ZW83.1
#=GS A0A7R5K4Q5_9PASS/2945-3050    AC A0A7R5K4Q5.1
#=GS A0A6P7LKR1_BETSP/392-497      AC A0A6P7LKR1.1
#=GS A0A384AI36_BALAS/4365-4472    AC A0A384AI36.1
#=GS A0A5F9DE47_RABIT/1390-1493    AC A0A5F9DE47.1
#=GS F1NRP8_CHICK/3952-4042        AC F1NRP8.4
#=GS A0A6P8XEG9_DROAB/1737-1844    AC A0A6P8XEG9.1
#=GS A0A2I4CTS4_9TELE/536-642      AC A0A2I4CTS4.1
#=GS A0A6I9PFH3_9TELE/1862-1970    AC A0A6I9PFH3.1
#=GS A0A0N4Y257_NIPBR/1938-2044    AC A0A0N4Y257.2
#=GS A0A2K6GTG7_PROCO/6323-6429    AC A0A2K6GTG7.1
#=GS A0A2I2YG61_GORGO/6767-6873    AC A0A2I2YG61.1
#=GS A0A671RQ41_9TELE/1277-1376    AC A0A671RQ41.1
#=GS A0A6J3ACS7_VICPA/1592-1696    AC A0A6J3ACS7.1
#=GS A0A1J1IJ94_9DIPT/3021-3125    AC A0A1J1IJ94.1
#=GS A0A0P9AS37_DROAN/2374-2480    AC A0A0P9AS37.1
#=GS A0A096NUI9_PAPAN/695-799      AC A0A096NUI9.2
#=GS A0A7E5VIM8_TRINI/3799-3909    AC A0A7E5VIM8.1
#=GS A0A0K0FFX3_STRVS/1494-1598    AC A0A0K0FFX3.1
#=GS A0A6P7F612_DIAVI/1287-1407    AC A0A6P7F612.1
#=GS A0A6J2V6T2_CHACN/736-838      AC A0A6J2V6T2.1
#=GS A0A2B4S4N9_STYPI/422-526      AC A0A2B4S4N9.1
#=GS A0A2I3M122_PAPAN/2019-2102    AC A0A2I3M122.1
#=GS A0A0B4K718_DROME/2934-3041    AC A0A0B4K718.1
#=GS A0A6J0CNE9_PERMB/2733-2840    AC A0A6J0CNE9.1
#=GS A0A7N4P7T0_SARHA/1477-1581    AC A0A7N4P7T0.1
#=GS A0A6P9A7S2_THRPL/2404-2508    AC A0A6P9A7S2.1
#=GS A0A674EF04_SALTR/403-508      AC A0A674EF04.1
#=GS A0A5F4CPF0_CANLF/5841-5946    AC A0A5F4CPF0.1
#=GS W5QJ36_SHEEP/954-1059         AC W5QJ36.1
#=GS A0A674KHL9_TERCA/4225-4332    AC A0A674KHL9.1
#=GS A0A2Y9N9U7_DELLE/5603-5709    AC A0A2Y9N9U7.2
#=GS A0A226NTQ1_COLVI/378-478      AC A0A226NTQ1.1
#=GS A0A341CU75_NEOAA/890-973      AC A0A341CU75.1
#=GS A0A4W5NR23_9TELE/469-573      AC A0A4W5NR23.1
#=GS A0A452G6A1_CAPHI/4492-4601    AC A0A452G6A1.1
#=GS A0A4U5V3J4_COLLU/746-850      AC A0A4U5V3J4.1
#=GS A0A0V1HHQ5_9BILA/1859-1963    AC A0A0V1HHQ5.1
#=GS A0A6J3FGL9_SAPAP/649-752      AC A0A6J3FGL9.1
#=GS A0A7N6ANK1_ANATE/376-484      AC A0A7N6ANK1.1
#=GS F6SIV4_HORSE/1061-1166        AC F6SIV4.2
#=GS A0A6J2K7S9_BOMMA/741-844      AC A0A6J2K7S9.1
#=GS A0A6J1XF45_ACIJB/255-359      AC A0A6J1XF45.1
#=GS A0A0L7R381_9HYME/1443-1547    AC A0A0L7R381.1
#=GS A0A1S3SZA8_SALSA/6634-6732    AC A0A1S3SZA8.1
#=GS A0A6P9AE07_THRPL/2295-2402    AC A0A6P9AE07.1
#=GS A0A1S2ZAV5_ERIEU/2258-2360    AC A0A1S2ZAV5.1
#=GS A0A2K5X002_MACFA/2128-2232    AC A0A2K5X002.2
#=GS A0A2Y9QNV4_TRIMA/314-422      AC A0A2Y9QNV4.1
#=GS A0A177BF72_9BILA/311-421      AC A0A177BF72.1
#=GS A0A671QPL4_9TELE/309-415      AC A0A671QPL4.1
#=GS A0A6J1PKR4_9HYME/3266-3372    AC A0A6J1PKR4.1
#=GS A0A671QH20_9TELE/368-473      AC A0A671QH20.1
#=GS A0A433TWQ3_ELYCH/2141-2248    AC A0A433TWQ3.1
#=GS A0A1S3NJX3_SALSA/901-1005     AC A0A1S3NJX3.1
#=GS A0A455ARI8_PHYMC/6908-7014    AC A0A455ARI8.1
#=GS A0A3Q7WDK3_URSAR/6165-6275    AC A0A3Q7WDK3.1
#=GS A0A673NAX7_9TELE/5544-5646    AC A0A673NAX7.1
#=GS A0A3M6TZK9_POCDA/2033-2137    AC A0A3M6TZK9.1
#=GS A0A672FW49_SALFA/1488-1592    AC A0A672FW49.1
#=GS A0A3P8Y6U5_ESOLU/2323-2430    AC A0A3P8Y6U5.2
#=GS E3NJ80_CAERE/156-260          AC E3NJ80.1
#=GS A0A286ZXS0_PIG/782-865        AC A0A286ZXS0.1
#=GS A0A665VSQ8_ECHNA/209-319      AC A0A665VSQ8.1
#=GS E2C952_HARSA/1485-1589        AC E2C952.1
#=GS A0A6P3YB47_DINQU/764-845      AC A0A6P3YB47.1
#=GS A0A6P8WRY9_DROAB/3144-3248    AC A0A6P8WRY9.1
#=GS A0A341BNJ5_NEOAA/201-306      AC A0A341BNJ5.1
#=GS A0A6J2JLZ8_BOMMA/4554-4664    AC A0A6J2JLZ8.1
#=GS A0A653CK59_CALMS/2259-2366    AC A0A653CK59.1
#=GS A0A5E4NL72_9HEMI/606-707      AC A0A5E4NL72.1
#=GS G5EC35_CAEEL/2728-2831        AC G5EC35.1
#=GS A0A5F4C669_CANLF/44-147       AC A0A5F4C669.1
#=GS A0A4W5N269_9TELE/1986-2068    AC A0A4W5N269.1
#=GS H3CBT9_TETNG/684-788          AC H3CBT9.1
#=GS A0A140UHX6_RAT/302-412        AC A0A140UHX6.1
#=GS A0A1U7QP03_MESAU/536-642      AC A0A1U7QP03.1
#=GS W5KTG2_ASTMX/701-805          AC W5KTG2.2
#=GS A0A674F418_SALTR/5605-5712    AC A0A674F418.1
#=GS A0A7M7SY23_STRPU/3009-3115    AC A0A7M7SY23.1
#=GS A0A672J1Q7_SALFA/1281-1384    AC A0A672J1Q7.1
#=GS A0A3Q2LBZ7_HORSE/6273-6380    AC A0A3Q2LBZ7.2
#=GS G3WFU1_SARHA/274-383          AC G3WFU1.2
#=GS E3LPH0_CAERE/1757-1862        AC E3LPH0.1
#=GS L5JR80_PTEAL/2037-2142        AC L5JR80.1
#=GS A0A6J1RNU4_9HYME/6634-6738    AC A0A6J1RNU4.1
#=GS A0A4W5N7E3_9TELE/1787-1891    AC A0A4W5N7E3.1
#=GS A0A6P4J2P4_DROKI/364-468      AC A0A6P4J2P4.1
#=GS A0A6P5CMP6_BOSIN/1756-1860    AC A0A6P5CMP6.1
#=GS F2U4B5_SALR5/593-696          AC F2U4B5.1
#=GS U3JFB5_FICAL/267-371          AC U3JFB5.1
#=GS F7AXP3_XENTR/133-214          AC F7AXP3.3
#=GS A0A6I9M4V3_PERMB/1564-1669    AC A0A6I9M4V3.1
#=GS A0A1S3SRB1_SALSA/7181-7278    AC A0A1S3SRB1.1
#=GS A0A3B0KTH6_DROGU/1126-1233    AC A0A3B0KTH6.1
#=GS A0A6J0C2E7_NEOLC/7288-7393    AC A0A6J0C2E7.1
#=GS A0A2Y9P1P3_DELLE/3959-4065    AC A0A2Y9P1P3.2
#=GS A0A5A9PL43_9TELE/2318-2423    AC A0A5A9PL43.1
#=GS A0A6I9ICI3_VICPA/1797-1901    AC A0A6I9ICI3.1
#=GS A0A7E6DPS3_9CHIR/1458-1561    AC A0A7E6DPS3.1
#=GS A0A485MS05_LYNPA/5506-5612    AC A0A485MS05.1
#=GS A0A7N5JC11_AILME/2765-2870    AC A0A7N5JC11.1
#=GS A0A5F8HJE1_MONDO/643-707      AC A0A5F8HJE1.1
#=GS A0A6J3II45_SAPAP/1513-1612    AC A0A6J3II45.1
#=GS A0A5A9PC03_9TELE/795-898      AC A0A5A9PC03.1
#=GS A0A3Q3AMB9_KRYMA/2013-2094    AC A0A3Q3AMB9.1
#=GS A0A6P8GJ64_CLUHA/4950-5057    AC A0A6P8GJ64.1
#=GS A0A3Q3GFS5_9LABR/958-1063     AC A0A3Q3GFS5.1
#=GS A0A2K5HVJ5_COLAP/6709-6806    AC A0A2K5HVJ5.1
#=GS A0A2Y9NWA8_DELLE/5271-5377    AC A0A2Y9NWA8.2
#=GS A0A1S3G195_DIPOR/263-366      AC A0A1S3G195.1
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#=GS A0A6P8GAG9_CLUHA/302-408      AC A0A6P8GAG9.1
#=GS A0A6J3L384_9HYME/2938-3044    AC A0A6J3L384.1
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