#=GF ID Sporozoite_P67
#=GF AC PF05642.14
#=GF DE Sporozoite P67 surface antigen
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_8657 (release 8.0)
#=GF GA 28.90 28.90;
#=GF TC 29.10 29.10;
#=GF NC 28.80 28.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 10024569
#=GF RT Linear peptide specificity of bovine antibody responses to p67
#=GF RT of Theileria parva and sequence diversity of
#=GF RT sporozoite-neutralizing epitopes: implications for a vaccine.
#=GF RA Nene V, Gobright E, Bishop R, Morzaria S, Musoke A;
#=GF RL Infect Immun 1999;67:1261-1266.
#=GF DR INTERPRO; IPR008845;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists of several Theileria P67 surface antigens.
#=GF CC A stage specific surface antigen of Theileria parva, p67, is the
#=GF CC basis for the development of an anti-sporozoite vaccine for the
#=GF CC control of East Coast fever (ECF) in cattle. The antigen has
#=GF CC been shown to contain five distinct linear peptide sequences
#=GF CC recognised by sporozoite-neutralising murine monoclonal
#=GF CC antibodies [1].
#=GF SQ 19
#=GS Q4UCF0_THEAN/1-260 AC Q4UCF0.1
#=GS B4Q5H9_DROSI/2-374 AC B4Q5H9.1
#=GS Q27040_THEPA/297-709 AC Q27040.1
#=GS Q27040_THEPA/142-298 AC Q27040.1
#=GS B4JLF1_DROGR/275-521 AC B4JLF1.1
#=GS B4KEJ9_DROMO/12-376 AC B4KEJ9.2
#=GS Q4UCF0_THEAN/318-454 AC Q4UCF0.1
#=GS A0A0Q9YV25_9COXI/86-335 AC A0A0Q9YV25.1
#=GS Q4UCF0_THEAN/449-917 AC Q4UCF0.1
#=GS U6GPL3_9EIME/3-285 AC U6GPL3.1
#=GS Q27040_THEPA/1-145 AC Q27040.1
#=GS U6K223_9EIME/457-736 AC U6K223.1
#=GS U6GL42_9EIME/177-474 AC U6GL42.1
#=GS A0A5N5DBX6_9PEZI/21-374 AC A0A5N5DBX6.1
#=GS A0A1W5Q009_DROME/7-369 AC A0A1W5Q009.1
#=GS U6LPV0_9EIME/671-969 AC U6LPV0.1
#=GS B4HXF2_DROSE/5-361 AC B4HXF2.1
#=GS A0A428YBX4_9ACTN/26-269 AC A0A428YBX4.1
#=GS A0A6L2PLV0_COPFO/389-648 AC A0A6L2PLV0.1
Q4UCF0_THEAN/1-260 .....................................MNIIHFLLTIPVIFVSGADKMPAGESSRTSKPSPLVTLESAVTQPSKDP.FKTISALSKATKVWKSAVSVSGDSKTVPTPVSEPMITRS.FQEP..................VSQELEFQSDTEINESGS.GSDEDEDD.DDDEEEEEDDKSTSSKNGKG.SPKA.QPGVSSSSTSSASPTSPT...........TTLSQTGLG.....PSGSH........AQQDPGVGV.P.GVgvpg..........................vgvpgVGVPGVG.V.PG.VGV.PGVGgvpGVGVAPGV.G..V..PGVGVA.PG.VGVG........AdSSGL................................................PGSGG......................................................................................................................L----.-------...-------------.................................................................................................................................................----------------------.-------------.---------------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------gagakagkgqg...............................................................
B4Q5H9_DROSI/2-374 ................................etipa-------------------------------------------------.---------------------------------------.----..................------------------.--------.--------------------.----.------------------...........---------.....-----........---------.T.PV...................................VSTDTAS.V.VG.VGV.GGVG...GGGAAAGA.GggA..GGAGGL.LG.DVVS........G.LGGGlvneseayaglmkdadklk.........lmllawnyqnstavrngtegP---Dlsvvgglwaqyqnalaqnaaaaaa......................................................................asgkmdsslspvprqdahspmetqDETNS.SGQKEED...EVSEDDSDDKLDEklatthdperiihlaihlvtsakrvsitsipsfqmfvrlfvdenldriipiskqpkekiqaiidscarqfpefsdrsrkrirtylkscrrnkktrdgwenttrptpahltsvqaeqilaiacenesmnakrmriglepithavpaPGSAVAAAA-AAAAAAAVVAAT.SSSAGGTSTTAAGnATATCGMG-------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------gvgdatgltsaaaaalp.........................................................
Q27040_THEPA/297-709 ...................................pp-------------------------------------------------.---------------------------------------.----..................------------------.--------.--------------------.----.------------------...........---------.....-----........---------.-.--...................................-------.-.--.---.----...--------.-..-..------.--.----........-.----................................................-----......................................................................................................................-----.-------...-------------.................................................................................................................................................----------------------.-------------.----------------------SAPVPSPGAPGIIVRES..........GNRAMDIVQFLGRFKPEPRAYEGERTNVAELKKFLFEELESLVNTLIELKLAIASDFVEITDGLRKNTKDHEARLKLLRGVEFTKRKSVANVVKGFSSLYCVLLMNMNVIKEKTKESEVADGIWKLSTIPDKVANELLLAMEKIVVPPKTPELEEAFEAIEFGFKIAYYATKDILSSIENTVHNLMHAKNYEENFIAQVRNSLRMVPHQMNLTESSFVIKISDMMRRRGTASQDEPAGAGSgvtpgrgssgtgraAGTGGGSLRGLDLSEEEVKKILDEIVKDPSDGELGLGDLSDPSGRSSERQPS-LGPSLVITDGQAGPTIVSPTGPTI------------AAGGEQPPSAPNGTATGPAGTQPEGGEKKEGLIQKLKKKLLGSGFEVASLMIPMATIIISIVH..........................................................................
Q27040_THEPA/142-298 ..................................stl-------------------------------------------------.-------------------STDVSPTIPTPVSEEIITPT.LQAQ..................TKEEVPPA-DLSDQVPSN.GS------.---DSEEEDNKSTSSKDEKE.LKKTlQPG-KTSTGETTSGQDLN...........SKQQQTGVSd...lASGSH........---------.-.--...................................--SSGLK.V.PG.VGV.PG--...--------.-..-..---AVS.PQ.GGQS........-.----................................................-----......................................................................................................................LASNT.SREGQAQ...HQQVRDGDGRVIE.................................................................................................................................................PKIGLPG---------------.-------------.---------------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------pp........................................................................
B4JLF1_DROGR/275-521 ..........................irhsdnlrshn-------------------------------------------------.-------------------------------SSSSVTSStYKSH..................SQQQMQQQQQHQQQQQHH.HSSQRRSH.DER-VRRRRDSRTRSRSGSR.SRTR.TPI-DTPPLRRRQGQQST...........RKYRRRESC.....DSSSRs.....rsP-----VER.P.PVhvrkpsd.....................vdphtrvYSTAGLL.Q.GK.LTL.PSTA...AVSAAAAL.N..A..AAISAAgSG.VGGG........G.VGGG................................................-----......................................................................................................................-----.-------...-------------.................................................................................................................................................----------------------.-------------.---------------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------ggllptpnyapkipslmslelnappsvlidgppaavqlpkyynpgivnanryaeqqqkrkliwgskknedsank
B4KEJ9_DROMO/12-376 ........................hketipaapatst-------------------------------------------------.---------------------------------------.----..................------------------.--------.--------------------.----.------------------...........---------.....-----........-------DT.S.SL...................................VGVGGGG.G.GG.VGG.GGVG..sGAGGAGSG.L..V..DIANSL.SG.GGSG........G.GGGG................................................GG--Itneseayaglmkdadklklmllawnyqnstavrngtegpdlsvv..............................gglwaqyqnalaqnaaavaaanskmdsslspvprqdapspmeaqDETNS.SGQKEED...EVSEDDSDDKLDEklatphdperlkafnmfvrlfvdenldriipiskqpkekiqaiidscarqfpefsdrsrkrir...................tylkscrrnkktrdgwenttrptpahltsvqaeqilaiacenesmnakrmriglepithavpaPGSVVAAAAAAAAVAGTSTTSA.SNAATVTCTAADA.---------------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------aglssvaaaalpfvsavgfarstpn.................................................
Q4UCF0_THEAN/318-454 ................................ggkpg-------------------------------------------------.---------------------------------------.--QP..................VSQELELKSDTEINES--.GSSSEGED.DDDEEEEEENKSTSSKGAGGkAGKG.QGSVSPGGGSSASQTSPT...........TT-PQSGLA.....SSGSHaq....qsPQQDPAPSK.P.SG...................................GGVPGVG.V.PG.VGV.PGVGv.pGVGVAPGV.G..V..V-----.--.----........-.----................................................-----......................................................................................................................-----.-------...-------------.................................................................................................................................................----------------------.-------------.---------------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------pgvg......................................................................
A0A0Q9YV25_9COXI/86-335 .....ltpndakdfqlvsaslahvnkkykavdltakv-------------------------------------------------.-----------------------A--KPSVSSEEEVSPS.KDAS..................NEDSKDASKDASKDASKD.ASKDASKDaSNEDSNEDSKASKSASEEKS.SAKE.EPAKKDEDKKTEENKAED...........AKKADEKKDedtqkASSSY........VTAASAVAG.V.GI...................................V-ATGFW.F.SG.F-Y.PSAV...ALLAKAGL.T..I..PAAAVA.AQ.VGVS........L.AVGI................................................AVVGVlalg..............................................................................................................yygiSKLFG.SSEVPAT...DEKTKEVENRT--.................................................................................................................................................----------------------.-------------.---------------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------edqkyhddlkakqdltaklaeh....................................................
Q4UCF0_THEAN/449-917 ....................................v-------------------------------------------------.---------------------------------------.----..................------------------.--------.--------------------.----.------------------...........---------.....-----........---------.-.--...................................-------.-.--.---.----...--------.-..-..------.--.----........-.----................................................-----......................................................................................................................-----.-------...-------------.................................................................................................................................................----VPGVG-GATTSSSSTTST.STSTTTTTTTSSGkPSNQGSHGTSPRNAVTRQTDSISGPIPSPGDPRAITGQMgllyssksfvGEGERFAVQFLGDFKPKPRRYEGQGTDAVKLKQFIFEEVKSLVQTLINLKLAIANDFVEISEKLKKKNQNYVPKLKLLKGEQFDTKQKVANVLKGFNSLYFVFFMNLNLAKEVNKPEELAEFLWKLNTIPDKVGREFELAIEKTKGSEKKKELEEAFNSIGLGFKIAQYATNDILSSITNSVYSLIKLKNFGDDFVTEVRKSLQMVPHQKNLNGSAFIVKISEIINKKGTEDQDQTSGSGS..............KGTEGGSLRGQDLTEEEVLKVLDELVKDVSEEHVGIGDLSDPSSRTPNAKPAELGPSLVIQNVPSDPSKVTPTQPSNLPQVPTTGPGNGTDGTTTGP-----GGNGEGGKDLKEGEKKEGLFQKIKNKLLGSGFEVASIIIPMTTIIFSIVH..........................................................................
U6GPL3_9EIME/3-285 ivktataaaaaaaataaaaagivaaavpqrrkkqqqq-------------------------------------------------.---------------------------------------.QQQD..................QQQQQQQQDQQQQQQQQDqQQQQHQQD.QQQQQQQQDQQQQQQQQQQE.QQQQ.QQQQDLLQQQQQQQQQQQ...........QQQQQQQQG.....DSGVHt......lQQRHPATAA.K.AA...................................ATATAVA.A.PA.LGA.AAAA...AAVAAADA.A..V..LAVAVV.VT.VATP........A.AGAVaaavaa....................................aaaaisP---Gpllcvllsklefspphnllpeaaaaaaaaa..........................................................tvaaaaaaaaaaklprnitnynctgsnsnsNSSNSnSSELQQQ...QQQ----------.................................................................................................................................................----------------------.-------------.---------------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------pqqkhhhlqqq...............................................................
Q27040_THEPA/1-145 .....................................MQITQFLLIIPVLFVSAGDKMPTEEQPFPSRLGPLVTLESAITQPTAVYtMRTVGNVAKAAKAWKSAVSSSDVSTTIPTPVSEENITST.LQTQteevpaasgsdsytvtnlVQTQSQVQDNVKQQQDTK.GNRSDSEE.ENEDS---------------.----.------------------...........---------.....-----........---------.-.--...................................-------.-.--.---.----...--------.-..-..------.--.----........-.----................................................-----......................................................................................................................-----.-------...-------------.................................................................................................................................................----------------------.-------------.---------------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------tls.......................................................................
U6K223_9EIME/457-736 .............................assnnppn-------------------------------------------------.---------------------------------------.----..................------------------.--------.------------TPSKGNLA.AHAA.TPAAAVPTTASATSTRRSaaaaaaaaaaaAAAAATPHA.....AGGTA........AGQTPAAAQgP.AA...................................AGGRGSA.A.DG.SPA.AGGG...GAAAAAGA.S..AaaAKAGET.PA.AAAA........G.AAAAaaaaaaaddgversaldeidfyqdhccsvcllpkvtasssnpffycarC---Gvtvhrmcygvpl.............................................................................................eclpaalrpdlqqQQQQQ.QQQQQQQ...QQQQQETSGSSLK.................................................................................................................................................RLKQTPGVQDNASSNSSSSSSN.SSSTSARTAGASA.---DGRDSSSSSSS-------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------sstpvtpaaipr..............................................................
U6GL42_9EIME/177-474 ..................taataaataaneaaaqpls-------------------------------------------------.---------------------------------------.----..................----------------RC.GFDKDNHL.EDEDAAAERSSSSSSSNSSS.SSNS.SSSSSSSKGKGASNVLNAv........eiVKQQETGLS.....PPAAAaataaaaaTAATPAAAA.A.AA...................................AGQQGKA.A.TA.ETT.PSTA...---ATAAA.A..A..TAAAAA.PR.LAARsflildepC.KGTA................................................PNCGAallgallealsavkaqgvicthlhhelss............................................................lglsfpnnsvkfkqisprrfysnqqqqqqQ---Q.QQQGQKQqqqQQQQQEQQELAAE.................................................................................................................................................GNSCQPPQDVYTSPSSSSPPSS.STSSSTTTTASSS.TSTTTS----SSS--------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------litkdedke.................................................................
A0A5N5DBX6_9PEZI/21-374 ................................pttta-------------------------------------------------.---------------------------------------.----..................------------------.------DA.DDD---DDDDDHTTSTSIPG.ASVG.TIAISIYSGGSATTTITL...........ATATVTSIS.....GSGGT........GGASAALTR.TvTA...................................VGTPGVS.G.NG.TAT.TTS-...ASATATGS.G..S..GSGDGD.SG.GGGG........T.GGGLsqa.........................................akigIGVGVplgvllllaivwgaymlgrhrrrpnssssspsspsdrgggilalltgnrrrrgrrlradsslsspdgreleedaekamlklagpaeletgpdrpelptavncqelaagdpfeqrrvfeEQQSR.RREGQQE...GQQQEEEGDRQQQeplvqe.....................................................................................................................................rlakelNGVGIAAGALEAAAGDRRRRRV.SSVSTNRKPVAKA.AASRGNGSDGGGSGSARGSYSSYSPIS------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------pvgtgsqsh.................................................................
A0A1W5Q009_DROME/7-369 ...........................asvllhketi-------------------------------------------------.---------------------------------------.----..................------------------.--------.--------------------.----.------------------...........---------.....-----........-------PA.T.PV...................................VSTDTAS.V.VG.VGV.GGGG...GAAAGAGG.G..A..GGAGGL.LG.DVVS........G.LGGGlvneseayaglmkdadklk.........lmllawnyqnstavrngtegP---Dlsvvgglwaqyqnalaqnaaaaaa......................................................................asgkmdsslspvprqdahspmetqDETNS.SGQKEED...EVSEDDSDDKLDEklatthdperlkafnmfvrlfvdenldriipiskqpkekiqaiidscarqfpefsdrsrkrir...................tylkscrrnkktrdgwenttrptpahltsvqaeqilaiacenesmnakrmriglepithavpaPGSAVAAAA-AAAAAAAVVAAT.SSSAGGTSTTAAGnATATCGMGG------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------vgdatgltsaaaaalpfvsa......................................................
U6LPV0_9EIME/671-969 ............................gvimkrdsi-------------------------------------------------.---------------------------------------.----..................METDLETEKETDMETGKE.TEKETEEE.TDMETEEETEKETDLETKKE.TGEL.QPLQQQQQQQQH-PHRRP...........QQQQQQEQQ.....QQQQQ........QQQQQQQGV.S.GVsplalllpkkngidffagnridcssgkirlllllqF---GLR.K.AA.AAA.AGAK..aGAGTAAAA.A..A..GKGAAA.AE.EGEN........G.AAAA................................................PAAAAaaaarsrrgvvf..............................................................................................tsprngskaaaaA----.-------...------------Erdkvrraqmteeeiqkqk............................................................................................................kwrekiqraerggtaadtpPAAAAAG--AGAAAAAKKKKKKrSSSSSDSSSSSSSsDSDSDS---------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------epstcvgyykd...............................................................
B4HXF2_DROSE/5-361 .............................rlretipa-------------------------------------------------.---------------------------------------.----..................------------------.--------.--------------------.----.------------------...........---------.....-----........---------.T.PV...................................VSTDTAS.V.VG.VGV.GGVG...GGGAAAGA.GggA..GGAGGL.LG.DVVS........G.LGGGlvneseayaglmkdadklk.........lmllawnyqnstavrngtegP---Dlsvvgglwaqyqnalaqnaaaaaa......................................................................asgkmdsslspvprqdahspmetqDETNS.SGQKEED...EVSEDDSDDKLDEklatthdperlkafnmfvrlfvdenldriipiskqpkekiqaiidscarqfpefsdrsrkrir...................tylkscrrnkktrdgwenttrptpahltsvqaeqilaiacenesmnakrmriglepithavpaPGSAVAAAA-AAAAAAAVVAAT.SSSAGGTSTTAAGnATATCGMG-------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------gvgdatgltsaaaaalp.........................................................
A0A428YBX4_9ACTN/26-269 .........................rhravtsadpep-------------------------------------------------.---------------------------------------.----..................------------------.--------.--------------------.----.------------------...........----DTNLN.....PSASP........---DPSVS-.P.GL...................................SVSPGVG.VsPG.VGVsPGVGvspGVGVSPGV.G..V.sPGVGVS.PG.VGVSpgv.gaspG.VGAS................................................PGVGA......................................................................................................................SPGLG.AESGLGT...GPDEIAEPARISSprppsgsqdqralrsrvlgtdeasetplrrarldglga....................................................................rvsvvgaervvevflahadsaavlvlrrsyetgdagpllAGRRVAGVSIGALAAGAVVTES.AARS---------.---------------------------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------asravrlgtrrlsrteamasrgsw..................................................
A0A6L2PLV0_COPFO/389-648 ...............................gspgqg-------------------------------------------------.---------------------------------------.----..................------------------.--------.--------------------.----.------------------...........---------.....-----........-------GV.P.GQ...................................GGYPGQGgA.PGqAGV.PGQGgypGQGGSPGQgG..V..PGQGGY.PGqGGSP........G.QGGV................................................PGQGGdpgqsspttpdtaisstpntpggtsassnictsegffpessnckkffrcvdng............kgaftkydfacgegtvwdpesnacnhnwavqrkdcrirehengagsiseqknnT----.-------...------------Qtttptsvenqk..........................................................................................................................sthtpggstfssPSITTSSSSSSSSSSSATTQSQ.SSSSTSTSSSSSN.ESNQESTTSSG-SGGQTATSS------------------..........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..............--------------------------------------------------------------------------------------------------------------------------------------------------------gtgsasn...................................................................
#=GC seq_cons .................................t..s.....................................................................................................................................................................................................................................s..s.sh...................................ssssGhu.s.sG.sus.susu...usususus.u..s..stsush.st.suss........s.huuh................................................s...s......................................................................................................................t..................................................................................................................................................................................ss......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sstt.t....................................................................
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