#=GF ID   Staphopain_pro
#=GF AC   PF14731.13
#=GF DE   Staphopain proregion
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF SE   CATH:1x9y_A_0
#=GF GA   27.00 27.00;
#=GF TC   31.30 141.50;
#=GF NC   26.10 26.10;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0320
#=GF RN   [1]
#=GF RM   15518582
#=GF RT   Prostaphopain B structure: a comparison of proregion-mediated
#=GF RT   and staphostatin-mediated protease inhibition.
#=GF RA   Filipek R, Szczepanowski R, Sabat A, Potempa J, Bochtler M;
#=GF RL   Biochemistry. 2004;43:14306-14315.
#=GF DR   INTERPRO; IPR028076;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is the proregion of the cysteine protease
#=GF CC   staphopain. Like many papain type peptidases, staphopain is
#=GF CC   synthesised as an inactive precursor and cleavage of the
#=GF CC   proregion is required for activation. This proregion has a
#=GF CC   half-barrel or barrel-sandwich hybrid fold. The proregion blocks
#=GF CC   the active site cleft of the mature enzyme on one side of the
#=GF CC   nucleophilic cysteine [1]
#=GF SQ   4
#=GS B9DIR7_STACT/40-179  AC B9DIR7.1
#=GS SSPP_STAA8/37-203    AC Q2G2R8.1
#=GS SSPB_STAA8/41-210    AC Q2FZL3.1
#=GS ECPA_STAEQ/42-210    AC Q5HKF6.1
B9DIR7_STACT/40-179             ap--LKVKVSNTEVPAKAEQQAETQFSSYAQALSQIDKSgTNGEYQLGKPFKIYKFNGQEDGNYYFPVL-QGEHIKYVLTVTPKNENDvNANKNSANYSVRISKFIADSLNQYRQAntPITIYTNKDGYF-AEHNHKIEMIKQ--------------------------------n
SSPP_STAA8/37-203               ..KHVQVNVEDKSVPTDVRNLAQKDYLSYVTSLDKIYNK.EKASYTLGEPFKIYKFNKKSDGNYYFPVLNTEGNIDYIVTISPKIT--.KYSSSSSKYTINVSPFLSKVLNQYKDQ..QITILTNSKGYYVVTQNHKAKLVLKTPRLEDKKLKKTESIPTGNNVTQLKQKASVTM.
SSPB_STAA8/41-210               ..KQLEINVKSDKVPQKVKDLAQQQFAGYAKALDKQSNA.KTGKYELGEAFKIYKFNGEEDNSYYYPVI-KDGKIVYTLTLSPKNKDDlNKSKEDMNYSVKISNFIAKDLDQIKDKnsNITVLTDEKGFY-FEEDGKVRLVKATPLPGNVKEKESAKTVSAKLKQELKNTVTPTK.
ECPA_STAEQ/42-210               ..KTTKVTVSNKDVPDAVRKLAEEQYLSRVALLDKASNH.KATSYTLGEPFKIYKFNKESDGNYYYPVLNKKGDVVYVVTISPNPSNS.KASKQQNNYSINVSPFLSKILNQYKNQ..KITILTNTKGYFALTEDGKVTLVLKTPRNNEKTYENATESTKPKDLNDFKQTASVTK.
#=GC seq_cons                   ..KplcVsVpsccVPscV+pLAppQahSYspuLDKhsNp.csupYpLGEPFKIYKFNtcpDGNYYaPVL.pcGcIsYllTlSPKspss.ptSKpssNYSlplSsFluKsLNQYKsp..pITILTNpKGYa.hpcstKlcLVhpTPh.tphp.cpstp.spsp.hpphKppsosTh.
//