#=GF ID   Ste5_C
#=GF AC   PF12194.11
#=GF DE   Protein kinase Fus3-binding
#=GF PI   ste5minscaffold;
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Gavin OL;
#=GF SE   pdb_3fze
#=GF GA   25.00 25.00;
#=GF TC   26.20 50.70;
#=GF NC   24.80 24.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0128
#=GF RN   [1]
#=GF RM   8943027
#=GF RT   Dimerization of Ste5, a mitogen-activated protein kinase cascade
#=GF RT   scaffold protein, is required for signal transduction.
#=GF RA   Yablonski D, Marbach I, Levitzki A;
#=GF RL   Proc Natl Acad Sci U S A. 1996;93:13864-13869.
#=GF DR   INTERPRO; IPR021106;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain family is found in eukaryotes, and is approximately
#=GF CC   190 amino acids in length. This domain is the penultimate C
#=GF CC   terminal domain from the protein ste5 which co-catalyses the
#=GF CC   phosphorylation of fus3 by ste7. It is involved in the MAPK
#=GF CC   pathways. This domain is the minimal scaffold domain of ste5. It
#=GF CC   binds to the mitogen activated protein kinase fus3 before it is
#=GF CC   phosphorylated.
#=GF SQ   29
#=GS Q6FL43_CANGA/371-561      AC Q6FL43.1
#=GS G0V9Z2_NAUCC/615-804      AC G0V9Z2.1
#=GS G0WGW1_NAUDC/642-832      AC G0WGW1.1
#=GS A0A1B7TIF5_9ASCO/490-680  AC A0A1B7TIF5.1
#=GS A0A0C7N9Q7_9SACH/565-756  AC A0A0C7N9Q7.1
#=GS A0A1G4MK69_LACFM/558-746  AC A0A1G4MK69.1
#=GS Q6CKB4_KLULA/499-686      AC Q6CKB4.1
#=GS A0A1S7HWK6_9SACH/577-766  AC A0A1S7HWK6.1
#=GS A7TJH8_VANPO/599-787      AC A7TJH8.1
#=GS A0A1G4JIU1_9SACH/568-756  AC A0A1G4JIU1.1
#=GS C5DN46_LACTC/557-744      AC C5DN46.1
#=GS J8Q9F9_SACAR/603-793      AC J8Q9F9.1
#=GS STE5_YEAST/594-785        AC P32917.2
#=GS STE5_YEAST/594-785        DR PDB; 3FZE A; 594-780;
#=GS STE5_YEAST/594-785        DR PDB; 4F2H A; 594-774;
#=GS A0A1S7HFF1_9SACH/577-766  AC A0A1S7HFF1.1
#=GS Q74ZU4_ASHGO/514-703      AC Q74ZU4.1
#=GS C5DSP8_ZYGRC/566-755      AC C5DSP8.1
#=GS A0A7H9B767_ZYGMR/606-793  AC A0A7H9B767.1
#=GS A0A1E5R6X5_HANUV/780-972  AC A0A1E5R6X5.1
#=GS A0A1X7R6A5_9SACH/583-771  AC A0A1X7R6A5.1
#=GS G8JS69_ERECY/510-700      AC G8JS69.1
#=GS I2H533_TETBL/650-838      AC I2H533.1
#=GS G8ZX41_TORDC/421-611      AC G8ZX41.1
#=GS J7S1Y2_KAZNA/648-844      AC J7S1Y2.1
#=GS A0A1E5RVE3_9ASCO/499-649  AC A0A1E5RVE3.1
#=GS G8BPS0_TETPH/605-793      AC G8BPS0.1
#=GS A0A1G4KIP3_9SACH/560-742  AC A0A1G4KIP3.1
#=GS A0A7H9I0P1_9SACH/582-770  AC A0A7H9I0P1.1
#=GS A0A376B763_9ASCO/731-927  AC A0A376B763.1
#=GS H2AR28_KAZAF/586-775      AC H2AR28.1
Q6FL43_CANGA/371-561                 ...TITSSVLSIKK.E.KPSDILLLIQIDE.QKITDq.....kdQIKQVIKNTLMAL....KL..KYPE....YFLVILSATGEVLLMDSI-DRLNLDN...QLL...SGEEPKNP...FRLEISSIRTHV...Y..GTS....I..LENLAIVAVSNSAMVETTSIL..........FKNFSPLISKGRLRPN..EIRIKVGY..SNNDYSDVVSELVEIESWDYLLEALCHTFSLDYDDDYTSY-e..
G0V9Z2_NAUCC/615-804                 ...TTISSILSLKR.E.RPDDVVIVLQIDF.KKIKN.......eDDYTTIYNTLKAL....TF..KFPR....LKACIVDAERNTLAIEPVADFIKNKD...ELR...NLKDREIG...KTFNIPWLKETL...Y..PSG....I..RQNIGIVVISNSSMENDKSVL..........LMDFQPFTCAGRRRPN..ELKLKVGY..LNVDYSEKVNELVEIESWCSLLETLCYSLTLNFDDDGDTYD...
G0WGW1_NAUDC/642-832                 ...TTISSILSLKR.E.RPDDIIIVLQLDL.NKLKL.......gNNSTTLYNSLTAL....NM..KFPN....FKICIVDSNSNVLAYGDVMKAVINAA...DIL...KCEHKNAG..nQNFTPEWLKNVF...Y..PNC....M..DQNIGIIVISNTVMELDKSCL..........FMDYKPFTCLGRRRPN..ELKIKVGY..LNVDYSDEINELVEIESWNYLLETLCYSMSLNFDDEDDEND...
A0A1B7TIF5_9ASCO/490-680             ..l-QISNLMPIKN.NlKPKDLIVVLQIDS.QKLIK.......kSENHNLINSIKAL....KN..YYELkkgiFRIVVLDETLKILSIGTANDILCQLN...GLI...SFTQIRGKklnGNLWSS-LVMQK...Y..YSE....T..ENDIGIVVLSNSEMKENTNCL..........FKDF--FGS----QEN..LLKVHIGY..LNVDYSDFITDLVEINTWMDLMEIICYSFDIEFGQDDCDD-e..
A0A0C7N9Q7_9SACH/565-756             ...TTITSLLSLQR.D.RPKNLAIVLQVDL.THLKD........TDFLALVNSLRAL....IM..NMKE....TQMCLVDPSGRMINQGVAEEQIAQLK...ILKiasRTSDADNR...PKFSPTQFKVAC...C..S-K....M..TDDVGIVVFSNTSVEAGKSCL..........FMDYKAFSSSNRSRPH..ELKVHVGF..LNVDYTDQVSELVEVSSFQNILETVSYGFNLTFGEDNDDF-dd.
A0A1G4MK69_LACFM/558-746             ..a-TITSILSLKR.E.RPESLIVVLQLSF.RYLND........SDTLIIRNSLKAL....TF..KFPG....ARMCVVDALGRIVTYGAINDNLSEIG...KAQ...EDTNCSSR...AKFTPELLKS-W...Q..NTD....S..DERLAIAIFSNSPMEEGKSCL..........FMDYKVFANENRREAN..ELKVRVGC..LNFDYADKIHQLVEIASWSNLLEIACYSFNFSFDEEDSED-sd.
Q6CKB4_KLULA/499-686                 ...TSISSILSIKR.A.TPNELNLVLQLDK.RKTNE........DNIVSIKNVILAL....TW..KFST....FNCCIVDVEGMVINCGTANDVL---N...SLA...GPIKSNGN...QPFSPDLLHQLW...YrqKQK....I..CKNVGVVVLSNSSMENGKSCL..........FSDYRIFADAGKRHPN..ELKIKVGF..LNVDYSDNIKELVEIQDWNELLEAVAYSFNLSFDDDLDSSD...
A0A1S7HWK6_9SACH/577-766             ...TNISSILSLKR.E.RPDELVVVLQLDY.DKVSS.......qKGQLVIYNSLKAL....GI..KFHN....MKICIVDTEGFVKTCGAAEEKLSTVD...DLM...NSASLPRE...ARFEPVWLKSRL...Y..ADG....P..LKSLGIAVVSNTCMDSQTSCL..........LRDYSCFTNVGRRRPK..ELKIKVGY..LNLDYSDKIGELVEVESWDNFLEALTYSFGLTFGDDDDEG-d..
A7TJH8_VANPO/599-787                 ...TSVSSILSLKR.E.RPEGIVIILQLDF.RKLKD........DSYIIIYNSLQAL....VT..KYPN....LIYCTVDADGFVVQYGQASKDILNLQ...SIY...KMNKPNAG...IKFSPTWLKNTI...Y..PLG....I..TSSLGIAILSNGSMEEARSCL..........LMDYKIFASPGRRHAN..ELKIKVGY..LNSDYSDKITELVEIGTWAFMLEALCYSFSLSFEDDDDDED...
A0A1G4JIU1_9SACH/568-756             ...TTITSLLSLKR.D.RPSNLAIVLQLEI.SRLKH........DELTTAVNSMRAL....VM..KMQE....TNICIVDQNARIVSQGPAQEQIAILA...NLS...SEMPNSPY...PQFTPELFKEI-...S..CIN....M..RATVGIAVFSNTSVEEGKSCL..........FMDFGCFANPKRTRPN..ELKAHIGY..LNFDYMDLVEELVEVSSFNDILETLCYCFNITFDEDDGD--cdd
C5DN46_LACTC/557-744                 ...TTITSLLSLKR.G.RPTLLALVLQLDP.SRLKD........AELIGLVNSLMAL....TF..KIRD....ARLCLVDLEGGIVSQGLVREQLSVVK...DLK...STVKDHNR...ARFNPADFKNEF...I..WEN....V..DK-IGIAVISNTLVESGKSCL..........FMDYNSFAGINRTRPH..ELKIHIGF..LNVDYTDCISELVEVASAHDLLETLCYGFNLSFEEEDDNND...
J8Q9F9_SACAR/603-793                 ...TTISSILSLKR.E.RPDNLVVILQVDF.RKVEK.......hGNLIVIYNSLKAL....MI..KFSL....LQFCFVDRNNNVLDYGLVSRKIDTVD...DIS...KLISKSLS...TQFSSRWLKDIL...Y..PGK....I..HEHLGIIAVSDSNMEAGKSVL..........FQDYKCFTSLGRRRPN..ELKVKVGY..LNVDYSDRIGELVEVGSWNFVLETLCYSFSLSFDEDDEEE-ed.
STE5_YEAST/594-785                   ...TTISSILSLKR.E.KPDNLAIILQIDF.TKLKE.......eDSLIVVYNSLKAL....TI..KFAR....LQFCFVDRNNYVLDYGSVLHKIDSLD...SIS...NLKSKSSS...TQFSPIWLKNTL...Y..PEN....I..HEHLGIVAVSNSNMEAKKSIL..........FQDYRCFTSFGRRRPN..ELKIKVGY..LNVDYSDKIDELVEASSWTFVLETLCYSFGLSFDEHDDDD-eed
#=GR STE5_YEAST/594-785        SS    ...HHHHHHHHHHH.T.--SEEEEEEEE-C.CC-SS.......TCCHHHHHHHHHHH....CC..C-TT....-EEEEEETTSBEEEEEEHHHH--SCH...HHH...HGGG----...-B--HHHHHHHH...-..TT-....-..-S-EEEEEEE-S---TTT-CC..........CS-GGGG--TT-SS--..EEEEEES-..-SS--TTTSSSEEEES-HHHHHHHHHHCTT--SSXXXXXX-XXX
A0A1S7HFF1_9SACH/577-766             ...TNISSILSLKR.E.RPDELVVVLQLDY.DKVCS.......qKCQLVIFNSLKAL....GI..KFHN....MKICIVDTEGFVKTCGAAEEMFCTVD...DLM...NSASLPQE...AKFEPVWLKSTL...Y..ADG....P..LKSLGIAVVSNTCMDSQTSCL..........LRDYSCFTNVGRRRPK..ELKIKVGY..LNLDYSDKIGELIEVESWDNFLEALTYSFGLTFGDDDDEG-d..
Q74ZU4_ASHGO/514-703                 ..a-SINSILSLKR.R.HPDELCLFFQIDT.AKVQA........VDYKILANTCKAI....LW..KFNT....AKVALADSNGGIVTMSLLKDFIPIFS...SID...HILRRHET..rRKLSPNLVYRHF...Y..GKE....R..LKNVGVCIISNSAMQYGKSLL..........LMDYSAFCNIGKKRPN..ELKVKVGY..LNTDYSDQVFELVETGGWGDVLEVVCYSFNMAFGQDDYSDD...
C5DSP8_ZYGRC/566-755                 ...TNISSILSLKR.E.RPDELVVVLQLDF.EKIRT.......kNNSLVIFNSLKAL....VL..KFPD....MKICIVDSGGFVRTLGRTKDVISTVE...DLE...DAQKLSEG...NRFEPIWLKNSL...Y..PDT....T..LKGLGIAIVSNTPMDTQKSCL..........LKDYSCFTNEGRRRPR..ELKIKVGY..LNLDYSDKVGELVELESWNNFLEALSYSFGLAFGDDDDDD-v..
A0A7H9B767_ZYGMR/606-793             ...TSISRILSLKR.E.TPDDLVIVLQLDY.EKLKK.......dNGFKIIDNSLRAL....NS..KFLS....LKLCLVDSDGFLIDSFLLGS--HHFT...SVM...EMASCNSD...RKFEPQWLKNKY...Y..PGG....L..TQNVGIAVISNSSMQNGKSSL..........LLDYDSFTCGGRRRPN..ELKVKIGY..LNADYSDRVNDLVEVESWNDLLEAVSYSFSIYFGDDDDDN-i..
A0A1E5R6X5_HANUV/780-972             .ne--VSTTLPIKSyS.EVEDLILILQLDSeKKIKI........SENFNLVNSIKSLndyfTK..KXKT....LKFVILDQKLKVLCVGSSKDVLNQLNgrmKFE...QIRGKKFT...ESFWSNSVLQKY...F..XST....E..DSKLNIVVMSNTEMNVEQNCL..........FKDFYASSF-----ED..VLKVHVGF..LNIDYSEEINDLVEINTWFDLMEILCFSLNLEFGQDDLDND...
A0A1X7R6A5_9SACH/583-771             ...TSISSIISMRR.K.KPDNLIVIIQIDK.RYVIS.......eDIYSTIYNNLKAL....EI..LFPS....LYICLVDSKMSLVRQGPASEIIKTPE...DL-...--KISTPI...CSFNSKLLRETV...L..NVT....IssSRTVGIALISNTMMNKESCIL..........FQQIALLRKMGELRAN..ILKIKVGY..LNMNYTDQIDELVEIDNWTDMLELLCYTFAIDYDSEDDNSD...
G8JS69_ERECY/510-700                 ...TRISSILSLKR.K.IPNDLFIVFQIDP.IKLLD........GDVNTLVNICKAL....SW..KLET....AKLCLVDKDGYLVTSCSLKLAIPKLK...GLN...SLLAEADR..sIKFSPADIYQQI...Y..GAW....Q..RENIGVTIISNSSMETGRSAL..........LMDYSAFCNVGKRRPN..ELKIKVGY..LNADYSDKVYELVETDKWNDVFEVICYSFNMAFGQDALTD-ed.
I2H533_TETBL/650-838                 ...TNVSLMVSLKR.D.CPEKMVLVLQLKD.NTIPQ........ETSRLIFNTIFAV....RS..RLSK....MQITIVNEDAMVIYFGEFLDKLDEFN...KL-...LVKDSSNN...IKFSPSWLKKQL...N.lSAG....S..TDNTAIAIVSEAAMKKGSSCL..........LMDYSPFAAKGKRIAN..EVKIKVGY..LNVDYTDQITELVEVGGWKFVLEMLCYSFSLNFEDDDDE--sy.
G8ZX41_TORDC/421-611                 ...TTVSSILSLKR.D.RPDELIVVLQWNL.KETNN........GLALDIYNNVRAL....SL..TYRD....LKVCIVNEEGRVANHALAKDFFTTSD...RVL...GLKDNNGT...VRFDPKWLKNTF...Y..PGN....I..TANIGIAVISDISLESDKSCL..........LMDYKPFARVGRRRPN..ELKVKIGYllLNVDYSKRIEELVEVGSWNQILEALSYSFSLAFGDDDEDDD...
J7S1Y2_KAZNA/648-844                 ...TTASSILSLKR.E.RADELILVIQLDF.DKLKEksggiggvSDYTTIFNTFKAL....SL..KYAR....LPFCVLNSAGYILKIGQVKQEFSNLK...CVE...EWIDLKPT...SKFDPKELKNIL...H..PEG....I..QKHIQLVIVSNSSMEEGMSSL..........LMDYRSFSAPKRRHAD..EIKIKVGY..LNVDYSDKIDELLEINSWEFMLEALCYNFSLNFDEDDDGVD...
A0A1E5RVE3_9ASCO/499-649             pws-----------.-.-------------.-----........-------------....--..----....VKLCCIDETGKVLSSGQISDVLKQLG...STP...GLQFSQIR..gKMLTSDYWDQTLiqxY..YQD....S..DTPIEVCIISNCGVXNSTGILsnpstntktnIMMWNNFFTLTKE--T..LCKIHIGY..LNEDIGD---ELIEINNWTEIMELLCVYYGFEFGQDFE---dl.
G8BPS0_TETPH/605-793                 ...TSFSSIISMKM.K.KPENLLLVVQIDF.RKLNQ........GEELVIKNTIRAL....TL..NYSD....LHMCFVDNHSKVIKIVPTKDIVNGTD...YFK...DLSQIKGS...TSFSPSWLLSEL...Y..PDG....V..KTSLGVSVISNTKMDETESIL..........FMDFDKFNGLGRKKVH..QLKVHVGF..LNIDYSEEIQELLEINNWNLLLESLCFTFDIVYGQDEDTVD...
A0A1G4KIP3_9SACH/560-742             ..g-TISSTLSLKK.S.KPSDLLVIFQLDL.RTVSQ........HDMRTLKNSLQAL....TL..QDEN....CKVCLVDIAGDVLSFGLIKEQLPNFG...QHK...KS-----Q...TPSNIQELVKST...-..AES....V..TSTFGIAVFSSTPMDKSKSYL..........FKDFKAFSQLERKKVK..ELKVHIGY..LNVDHSDEISELAEISSWENMIEMMCFAFNMTFDDDDDDDD...
A0A7H9I0P1_9SACH/582-770             ...TSISSILSLKR.E.KPDDLVVVLQFNF.EDPNF.......fNSLPIIHNNIKAL....NI..KFRD....LKICVVNEKGYVIQHGHVDKITFDPD...SIT...SLQKTSGT...NKFNPEWLRNTF...Y..PNG....V..LGNVGVAVVSASSMEEGKSCL..........LMNYKPFTCPGRRRPN..ELKVKVGY..LNVDYSDSIEELVEVAAWANVLEALSYSFSLVFGDDEDE--e..
A0A376B763_9ASCO/731-927             ...TIITFYLTLKK.R.EPTELIIVLQLDSeKKITQ........IQNNNLINAIKAL....NTypKLKK....LHLCCISEDLKILCFGSTTHVLSQMS...SGL...NFKQF-RG...ATFTPEDLFYKI...Y..PHGasndF..LNDVGLVVISNSSMNESKSCL..........FMNYNIFGSNPTQFENfsGIKIHVGF..LNVDYSNKISELLEIDTWNDLLEVISFTFNIKFGEDSEE--vv.
H2AR28_KAZAF/586-775                 ...TTISSILSLKR.E.RPDDLVIIFQIDF.FKVKN.......nDDILNFYNILKAL....LL..KFPE....CKFCAVNTAGFIIDYGLITEKVEGPD...YFQ...VINKVDGT...IKFEPTWLKSLL...F..PQE....I..RHNVAIVIVSNSSMEADKSCL..........LMDYNPFASNGRRRPN..ELKVKVGY..LNIDYSDKINELIEIDSWSVLLEALCYSFTLNFDEDEGS--ey.
#=GC SS_cons                         ...HHHHHHHHHHH.T.--SEEEEEEEE-C.CC-SS.......TCCHHHHHHHHHHH....CC..C-TT....-EEEEEETTSBEEEEEEHHHH--SCH...HHH...HGGG----...-B--HHHHHHHH...-..TT-....-..-S-EEEEEEE-S---TTT-CC..........CS-GGGG--TT-SS--..EEEEEES-..-SS--TTTSSSEEEES-HHHHHHHHHHCTT--SSXXXXXX-XXX
#=GC seq_cons                        ...ToISSILSLKR.-.+P--LllVLQlDh.pKlpp........sshhslhNol+AL....sh..Katp....h+lClVDpsGhllshG.sp-hlsphs...sl....phpptsss...tpFsPphL+pph...Y..sps....h..ppslGIsllSNosM-ps+SsL..........hhDYpsFsshGR+RPN..ELKlKVGY..LNlDYSDcIsELVElsoWsslLEsLCYSFsLsFs-DD--s....
//