#=GF ID T3SS_needle_reg
#=GF AC PF09025.16
#=GF DE YopR, type III needle-polymerisation regulator
#=GF PI YopR_core;
#=GF AU Mistry J;0000-0003-2479-5322
#=GF AU Sammut SJ;0000-0003-4472-904X
#=GF SE pdb_1z21
#=GF GA 25.00 25.00;
#=GF TC 25.70 32.40;
#=GF NC 24.20 23.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 90746521 -E 1000 --cpu 8 HMM pfamseq
#=GF TP Domain
#=GF WK YopR_bacterial_protein_domain
#=GF CL CL0646
#=GF RN [1]
#=GF RM 15930010
#=GF RT Crystal structure of the protease-resistant core domain of
#=GF RT Yersinia pestis virulence factor YopR.
#=GF RA Schubot FD, Cherry S, Austin BP, Tropea JE, Waugh DS;
#=GF RL Protein Sci. 2005;14:1679-1683.
#=GF RN [2]
#=GF RM 19968786
#=GF RT YopR impacts type III needle polymerization in Yersinia species.
#=GF RA Blaylock B, Berube BJ, Schneewind O;
#=GF RL Mol Microbiol. 2010;75:221-229.
#=GF DR INTERPRO; IPR013349;
#=GF DR TC; 3.A.6;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The YopR core domain, predominantly found in the
#=GF CC Gammaproteobacteria virulence factor YopR, is composed of five
#=GF CC alpha-helices, four of which are arranged in an antiparallel
#=GF CC bundle. Little is known about this domain, though it may
#=GF CC contribute to the virulence of the protein YopR [1]. YopR
#=GF CC controls the selective access of early (YscF, YscI and YscP)
#=GF CC substrates to the type III secretion machines of yersiniae and
#=GF CC other Gammaproteobacteriae. YopR is a mobile regulatory
#=GF CC component thought to function as a checkpoints probing the
#=GF CC completion of discrete intermediary stages in the assembly of
#=GF CC the type III injection pathway. The location of secreted YopR
#=GF CC (into the medium) is directly controlling the secretion of YscF,
#=GF CC the polymerised needle protein Pfam:PF09392, thereby impacting
#=GF CC the assembly of type III machines [2].
#=GF SQ 7
#=GS A8T5N3_9VIBR/79-210 AC A8T5N3.1
#=GS D0Z4V1_PHODD/83-173 AC D0Z4V1.1
#=GS E3BLT3_9VIBR/10-152 AC E3BLT3.1
#=GS A0A105T2U0_9PSED/24-136 AC A0A105T2U0.1
#=GS Q7N0U6_PHOLL/39-187 AC Q7N0U6.1
#=GS YOPR_YERPE/24-164 AC P68590.1
#=GS Q9I316_PSEAE/30-142 AC Q9I316.1
A8T5N3_9VIBR/79-210 ..................................avsrslegrfts-------------------------SSAMRDALWYAFNQ-EKSLKGTDNASPEL--FVS.LEQELLGSFSRRL-LADPPQDRAELKALLSEHFPFNAQKEQALWRSWAELKGASD------QDALLEMVRKETVTVMQINSLVKNMLNNSHKIDF-s
D0Z4V1_PHODD/83-173 .............................dkaspellgsfsgrlla-----------------------------------------------------------.----------------DPPKDREELKVLLSEHFPLGAQKEQALWHSWAKLQD------IPDQELLLDMVRKELSFVIQINSMVKNMLTYSHKLEL-s
E3BLT3_9VIBR/10-152 nwqdqeatlspvsaddvnkmarlmsdrtsdkrvssrektpdsnvss----------------------------------------------------E--ISTPsVKDDSFDRFLNDLM-AKMPKDRQELKALLSEHFSLGKHKEQALIHSLKALKE----KGDPGQAPLMDLVQKEWGFLIQTNAMIKNLVTYSHKLDLE.
A0A105T2U0_9PSED/24-136 arpadthafeqamqtpveatkpvsavtlqvlqtlqanagndeqarl-----------------------------------------------------------.-----------------------ALKHLIKQDAPFAKQQQEALLRVLGEIKP------LPDTTGASRVINTELRHLIPLAGMIDHLMRHTHKPDLE.
Q7N0U6_PHOLL/39-187 ..............................................QQMLKERQQRWLQGEPLENVLGDLDPATQRKVIWQWYQALSSDKQPSQRAQLQAKLIAP.VQERLWSQFGGLAGNIKPPLDMPELRKIVREFAPTGRQQETVLLEVLGEIKP------IPGNEYLSDLIRQELKTLIPRNGMVDNLIRNSHKPDLE.
YOPR_YERPE/24-164 .....................................qpvaselkt---------------QLENKLKSESAEKTREVLWQQYYA----SNPPDHAVLEV-LATP.VREALLARFGQHQGSVVPAIDLPELRSVLQQFDSFGKRWEAILLQVLEGIKPNESQVGLP---YLSELINKELMILLPSNSIVDSLLHNSHQIDMD.
Q9I316_PSEAE/30-142 .....................lafeqalggeppaagrrlaglenga-----------------------------------------------------------.LGERLLQRFAQPLQGL--EADRLELKAMLRAELPLGRQQQTFLLQLLGAVEH------APGGEYLAQLARRELQVLIPLNGMLDNLVRNSHKLDLE.
#=GC seq_cons ..................................th.ts.stphts............................................................ltpt.htpF.t....h..shDh.ELKslLppahPhG+QpEpsLlcsLutlKs......hPspphL.-llp+ELthLI.hNuMlcNLlppSHKlDL-.
//
