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Database: Pfam
Entry: T3SSipB
LinkDB: T3SSipB
Original site: T3SSipB 
#=GF ID   T3SSipB
#=GF AC   PF16535.7
#=GF DE   Type III cell invasion protein SipB
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_3tul
#=GF GA   31.00 31.00;
#=GF TC   32.90 32.80;
#=GF NC   30.80 30.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   8801431
#=GF RT   Functional conservation of the Salmonella and Shigella effectors
#=GF RT   of entry into epithelial cells.
#=GF RA   Hermant D, Menard R, Arricau N, Parsot C, Popoff MY;
#=GF RL   Mol Microbiol. 1995;17:781-789.
#=GF RN   [2]
#=GF RM   7608068
#=GF RT   Homologs of the Shigella IpaB and IpaC invasins are required for
#=GF RT   Salmonella typhimurium entry into cultured epithelial cells.
#=GF RA   Kaniga K, Tucker S, Trollinger D, Galan JE;
#=GF RL   J Bacteriol. 1995;177:3965-3971.
#=GF RN   [3]
#=GF RM   10051653
#=GF RT   The Salmonella invasin SipB induces macrophage apoptosis by
#=GF RT   binding to caspase-1.
#=GF RA   Hersh D, Monack DM, Smith MR, Ghori N, Falkow S, Zychlinsky A;
#=GF RL   Proc Natl Acad Sci U S A. 1999;96:2396-2401.
#=GF RN   [4]
#=GF RM   10972796
#=GF RT   Membrane fusion activity of purified SipB, a Salmonella surface
#=GF RT   protein essential for mammalian cell invasion.
#=GF RA   Hayward RD, McGhie EJ, Koronakis V;
#=GF RL   Mol Microbiol. 2000;37:727-739.
#=GF RN   [5]
#=GF RM   14662750
#=GF RT   A Salmonella protein causes macrophage cell death by inducing
#=GF RT   autophagy.
#=GF RA   Hernandez LD, Pypaert M, Flavell RA, Galan JE;
#=GF RL   J Cell Biol. 2003;163:1123-1131.
#=GF RN   [6]
#=GF RM   16159789
#=GF RT   Multinucleated giant cell formation and apoptosis in infected
#=GF RT   host cells is mediated by Burkholderia pseudomallei type III
#=GF RT   secretion protein BipB.
#=GF RA   Suparak S, Kespichayawattana W, Haque A, Easton A, Damnin S,
#=GF RA   Lertmemongkolchai G, Bancroft GJ, Korbsrisate S;
#=GF RL   J Bacteriol. 2005;187:6556-6560.
#=GF RN   [7]
#=GF RM   22975346
#=GF RT   Membrane topology of Salmonella invasion protein SipB confers
#=GF RT   osmotolerance.
#=GF RA   Asakura H, Ekawa T, Sugimoto N, Momose Y, Kawamoto K, Makino S,
#=GF RA   Igimi S, Yamamoto S;
#=GF RL   Biochem Biophys Res Commun. 2012;426:654-658.
#=GF RN   [8]
#=GF RM   22321794
#=GF RT   The structures of coiled-coil domains from type III secretion
#=GF RT   system translocators reveal homology to pore-forming toxins.
#=GF RA   Barta ML, Dickenson NE, Patil M, Keightley A, Wyckoff GJ,
#=GF RA   Picking WD, Picking WL, Geisbrecht BV;
#=GF RL   J Mol Biol. 2012;417:395-405.
#=GF DR   INTERPRO; IPR032391;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   T3SSipB is a family of pathogenic Gram-negative bacterial
#=GF CC   proteins that invade human intestinal cells via the type III
#=GF CC   secretion system translocators. T3SSipB represents the coiled
#=GF CC   -coil region of the proteins and is shown to be homologous in
#=GF CC   activity to the pore-forming toxins of other Gram-negative
#=GF CC   pathogens, such as colicin Ia [1-8].
#=GF SQ   23
#=GS A9MF89_SALAR/82-234       AC A9MF89.1
#=GS A0A4Z0LEJ9_SALET/82-234   AC A0A4Z0LEJ9.1
#=GS A0A1N7SC18_9BURK/107-267  AC A0A1N7SC18.1
#=GS Q326S9_SHIDS/76-231       AC Q326S9.1
#=GS BIPB_BURPS/99-261         AC Q63K34.1
#=GS A0A4R1NFA6_9GAMM/95-246   AC A0A4R1NFA6.1
#=GS A0A6I4LQH6_9ENTR/84-240   AC A0A6I4LQH6.1
#=GS A0A0F7HEC7_SERFO/262-339  AC A0A0F7HEC7.1
#=GS A0A0X1T887_PSEAA/79-239   AC A0A0X1T887.1
#=GS A0A5E4TBS3_9BURK/81-232   AC A0A5E4TBS3.1
#=GS Q7NUS8_CHRVO/81-233       AC Q7NUS8.1
#=GS G8Q409_PSEF3/85-238       AC G8Q409.1
#=GS A0A4U2UGT3_9ENTR/94-245   AC A0A4U2UGT3.1
#=GS A0A4R3YYT3_9ENTR/98-251   AC A0A4R3YYT3.1
#=GS A0A2X4WDD8_SALER/1-121    AC A0A2X4WDD8.1
#=GS IPAB_SHIFL/76-231         AC P18011.2
#=GS IPAB_SHIFL/76-231         DR PDB; 5WKQ A; 76-231;
#=GS IPAB_SHIFL/76-231         DR PDB; 3U0C B; 76-224;
#=GS IPAB_SHIFL/76-231         DR PDB; 5WKQ B; 76-230;
#=GS IPAB_SHIFL/76-231         DR PDB; 3U0C A; 76-224;
#=GS A0A239S6G5_9BURK/83-235   AC A0A239S6G5.1
#=GS A0A3S4I3Q7_SALBN/82-234   AC A0A3S4I3Q7.1
#=GS A0A4Q2J256_9BURK/87-242   AC A0A4Q2J256.1
#=GS SIPB_SALTY/82-234         AC Q56019.1
#=GS SIPB_SALTY/82-234         DR PDB; 3TUL B; 83-227;
#=GS SIPB_SALTY/82-234         DR PDB; 3TUL D; 83-226;
#=GS SIPB_SALTY/82-234         DR PDB; 3TUL A; 82-226;
#=GS SIPB_SALTY/82-234         DR PDB; 3TUL C; 84-225;
#=GS A0A0N0E431_9PSED/79-231   AC A0A0N0E431.1
#=GS A0A0J6RGR6_9NEIS/79-231   AC A0A0J6RGR6.1
#=GS A0A4R0Z222_9GAMM/80-232   AC A0A4R0Z222.1
A9MF89_SALAR/82-234                  ......EGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKAMGLQVSKEFQAALGEAEKATDIYEESIKKMDTAKSVYDTAAKKLTQAQN.............KLQSMDPSDPGYAKA....EAAEGQAR--...KE.AK.DAKTAF..DKAKKAADLAGTDAKTKTEQA.DNILTKFQGT-t................
A0A4Z0LEJ9_SALET/82-234              ......EGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKRVYAAAAKNLTQAQN.............NLQSLDPADPGYAQA....EAAVEQAG--...KE.AT.EAKEAL..DKATDATLNAGTDAKAKAEKA.DNILTKFQGTA.................
A0A1N7SC18_9BURK/107-267             ......AARLTQIVSDLMKLIGRGSLDELEKNAKLWHALSDAAKEQLENVSRAYKRAAQDAADAVAAAKDAADIAERARHEADAADKSAEEAKE.............QLDRAGNNHAPQAEL....DRLKAEWEKA...RDvAK.RADNTA..HAAASRAEAAKQQAVDASNSA.ADAE-------savdsavinaqt.....
Q326S9_SHIDS/76-231                  ......SSQLTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNLEFSDKINTLLSETEGLTRDYEKQINKLKNADSKIKDLENKINQIQT.............RLSELAPDSPEKKKL....RREEIQLTIK...KD.AA.VKDRTLieQKTLSIHSKLTDKSMQLEKEI.DSFSA-FSNTA.................
BIPB_BURPS/99-261                    ......AAKLTELLGVLMSVISASSLDELKQRSDIWNQMSKAAQDNLSRLSDAFQRATDEAKAAADAAEQAAAAAKQAGADAKAADAAVDAAQKryddavkqglpddRLQSL------KAAL....EQARQQAGDAhgrAD.AL.QADA--..TKKLDAASALATQARACEQQV.DDAVNQATQQY.................
A0A4R1NFA6_9GAMM/95-246              ....sa--VFTLLAGNAMMLLGNHSLVQLADRLQIIQANSEALQQANEALAQQFQQAVDSSAAALSAAEADSASLQTAQNSLAEKQENYDQAKN.............RLDLLSPEDPEYTAAlsrfESAERELSDA..aRD.VA.QAQVKA..GESYQAA--------------.-----------resslllddlfrkmqgp
A0A6I4LQH6_9ENTR/84-240              .....d-ARLTMILGNLTGIADQDITTRLHNNLDSTLLRHEMAHNKFRELSDAYASSLDSAQKADDIMHQANNNYNAVDKKVQSLEKKVNTLNQ.............ELSQLQPGDPQYNKV....LTQKNAAEKT..lTL.SL.QKKSLA..EKSLNTAIMDADAAIGQSMEIfDEIQ-------qqeqinn..........
A0A0F7HEC7_SERFO/262-339             ......AATLSLLLGKFIQSVGDQSVEDLKNDLAITNTMREANQKDMLKKSEEFAEQQRKAEEASKA---------------------------.............---------------....----------...--.--.------..---------------------.-----------tgclgkiiggiatavga
A0A0X1T887_PSEAA/79-239              ....eg--EFVRLIASLIELLGNANLESLKNRLSMLRAVTQSSQQGLDRLSADYKQALGELVAAQGAVDTSQEQLQLLKDRLDQAQIELEAAES.............HLASLDPSSPEYADA....LARRDAAKAA...LG.GL.QQG--F..EAALKAHLGLLATAKSVAIRT.EALARQVQ---aagidgkvvdq......
A0A5E4TBS3_9BURK/81-232              ......AGALTEMLTRLVDQLGTSSLAAIDARLAAWQAKNDVRSNAGEKLSAEYEAAKQGVSDAIAAYEDALKALADAIAQAKAAQDRVDKLRG.............ERDALTPGTLAYDAA....MQKHETAM--...QS.AA.QAENAV..AARRAEAERAQTAAAAAVNAA.DKLLN------dglnt............
Q7NUS8_CHRVO/81-233                  ......AGKLTLLLGQLMSLLGNVSLSQLESRIATWRAMMEAQVAMGEKLSQEFQDAFKAASEATEALKDAVGNYDSAKQAADAAQKKADAAQA.............KVDGMSPDEPGYAEA....QAASQQAA--...AD.AL.QAKQKA..DKAYDAAEKARVVAVEKGKVA.DDLAGKVQGAN.................
G8Q409_PSEF3/85-238                  ..sgdl---FTLLMAMISELIGEVDVKKLKNRLAMLQSMAGARQQGHENLSAEYAAAVEAMAAAEGNVGSSQEHLDQLQERVLHFQALLQESEV.............RLAQLDPESPEYAQE....LALRDQLR--...GD.VA.SHTQTL..QTATAAHLKLIEVANACARTV.TAVVAKMQE--ss...............
A0A4U2UGT3_9ENTR/94-245              .....t-ARFTQLAGNAMRLLGNASLSQLASRLEVMMANSHALQQRNEALYMQFQQAAEHSTAATAQAEADLASLDAAAQQLADKQQAYDQAKL.............ALSQLAPQDPGYEAA....YGQLQTA---...EL.ALnQAREQW..GKAESLAQQSYAAAREAVLAV.DDLLI------rlesl............
A0A4R3YYT3_9ENTR/98-251              nasfvk------VMSDLMVLLGSISLADLAGRLKIFQSAANAKKQHNEARAAEYDKAVKANETALKNAQADMDAANADKGDLAQRQQSVKDCEA.............ALQKLKPGDPAYPQA....EKKLQQAQKR..eAL.AV.GKYRQA..QQKADASYQVARDAFSKLDQL.DK---------qiraddk..........
A0A2X4WDD8_SALER/1-121               ......--------------------------------MIESQKAMGLQVSKEFQAALEEAEKATDIYEESIKKMDTAKSVYDTAAKKLTQAQN.............KLQSMDPSDPGYAKA....EAAEGQAR--...KE.AK.DAKTAF..DKAKKAADLAGTDAKTKTEQA.DNILTKFQGT-t................
IPAB_SHIFL/76-231                    ......SSQLTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNLEFSDKINTLLSETEGLTRDYEKQINKLKNADSKIKDLENKINQIQT.............RLSELDPESPEKKKL....SREEIQLTIK...KD.AA.VKDRTLieQKTLSIHSKLTDKSMQLEKEI.DSFSA-FSNTA.................
#=GR IPAB_SHIFL/76-231         SS    ......HHHHHHHHHHHHHHH-SGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.............HHHCS-SS-SHHHHH....HHHHHHHHHH...HH.HH.HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.HCHHH-HHHHS.................
A0A239S6G5_9BURK/83-235              .....r-ASLTYLLGRLTELFSHSSLSDLQNRLKQSQLEAASRQAMAEQSQAEFDQAVAAATQAMDALDQATQHLADAEQALANAQETLTNTKA.............ALDSATPGTPEYDAA....MQAYEAAKSG...YD.AA.KARH--..DQAKHEATQAFEAAKDATRKA.DDILGKFLG--nq...............
A0A3S4I3Q7_SALBN/82-234              ......EGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQSALGEAQEATDLYEASIKKTDTAKSVYDAAAKKLTQAQN.............KLQSLDPADPSYAQA....EAAVEQAG--...KE.AT.EAKEAL..DKAADATVKAGTDAKAKAEKA.DSILTKFQGTA.................
A0A4Q2J256_9BURK/87-242              .....g-ATLMLLLGQLNELLGLAGMTELNTRIAAFKEAAEARSAALAEGAEKFSDAVTVADAAVTAYAGGKEQAAAARAAMDGAQAEAAAAEA.............ELQALEEGDPARPQA....MHKFEAAQ--...KT.LT.AATQKY..AGAVENEKRLSDDVVQKVRIA.ADL--------ekkamadgaas......
SIPB_SALTY/82-234                    ......EGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKSVYDAATKKLTQAQN.............KLQSLDPADPGYAQA....EAAVEQAG--...KE.AT.EAKEAL..DKATDATVKAGTDAKAKAEKA.DNILTKFQGTA.................
#=GR SIPB_SALTY/82-234         SS    ......XXCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHTTTTT----STHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.............HHTT---------CH....HHHHHHHH--...HH.HH.HHHHHH..HHHHHHHHHHHHHHHHHHHHH.HTXXXXXXXXX.................
A0A0N0E431_9PSED/79-231              ....eg--EFVRLIASLVELLGNSSLESLKNRLSLLRSMAHASQQALQQLSADYAGALAELVAAQGDVDTSQERLEALKARLDQAQPELDAAES.............HLASLNPSSPEYAEA....LARRDRAK--...AA.VA.PLQQGF..SQAADAHVQLLGKAKLAAIRA.EGLARQVQDK-a................
A0A0J6RGR6_9NEIS/79-231              ......AGKLTLLLGQLMSLLGNVSLSQLESRIATWRAMMEAQVAMGEKLSKEFQDAFKAASEATEALKDAVGNYDSAKQAADAAQKKADAALA.............KLNGMSPDDPGYADA....QAASQQAS--...GE.AA.QAKQKA..DKASEVAEKARVVAVEKGKIA.DDLAGKVQGAN.................
A0A4R0Z222_9GAMM/80-232              .....l-ARLRELMGEFSGVVDGARGAKLRGDLLIWLDRQKTRQGVLDQLSSKFRGASDAYRDALDELTRRGKAVQAAADEANRLSREVGRLKD.............LLQGLSPDDPKRAEL....EGALAAAR--...RD.AG.QATQSL..DVALKRLQDGVDKAEHAAKDV.DALSDAV----rhes.............
#=GC SS_cons                         ......HHCHHHHHHHHHHHHHCHCHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.............HHCCS-SS-SHHHCH....HHHHHHHHHH...HH.HH.HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.HCHHHXHHHHS.................
#=GC seq_cons                        .......upLThLlGpLhpLLGssSLspLcsRLshapuhtcuppptspplSp-FpsAlspuppAscsh-suhpphcsAcsthcsAppclspAps.............cLpuLsPscPtYspA....pstpppAp.....p-.As.pAcpth..spAhcss.pstssAhttscps.Dslhs.h....t................
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