#=GF ID T3SSipB
#=GF AC PF16535.8
#=GF DE Type III cell invasion protein SipB
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE pdb_3tul
#=GF GA 31.00 31.00;
#=GF TC 32.90 37.80;
#=GF NC 30.80 30.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 8801431
#=GF RT Functional conservation of the Salmonella and Shigella effectors
#=GF RT of entry into epithelial cells.
#=GF RA Hermant D, Menard R, Arricau N, Parsot C, Popoff MY;
#=GF RL Mol Microbiol. 1995;17:781-789.
#=GF RN [2]
#=GF RM 7608068
#=GF RT Homologs of the Shigella IpaB and IpaC invasins are required for
#=GF RT Salmonella typhimurium entry into cultured epithelial cells.
#=GF RA Kaniga K, Tucker S, Trollinger D, Galan JE;
#=GF RL J Bacteriol. 1995;177:3965-3971.
#=GF RN [3]
#=GF RM 10051653
#=GF RT The Salmonella invasin SipB induces macrophage apoptosis by
#=GF RT binding to caspase-1.
#=GF RA Hersh D, Monack DM, Smith MR, Ghori N, Falkow S, Zychlinsky A;
#=GF RL Proc Natl Acad Sci U S A. 1999;96:2396-2401.
#=GF RN [4]
#=GF RM 10972796
#=GF RT Membrane fusion activity of purified SipB, a Salmonella surface
#=GF RT protein essential for mammalian cell invasion.
#=GF RA Hayward RD, McGhie EJ, Koronakis V;
#=GF RL Mol Microbiol. 2000;37:727-739.
#=GF RN [5]
#=GF RM 14662750
#=GF RT A Salmonella protein causes macrophage cell death by inducing
#=GF RT autophagy.
#=GF RA Hernandez LD, Pypaert M, Flavell RA, Galan JE;
#=GF RL J Cell Biol. 2003;163:1123-1131.
#=GF RN [6]
#=GF RM 16159789
#=GF RT Multinucleated giant cell formation and apoptosis in infected
#=GF RT host cells is mediated by Burkholderia pseudomallei type III
#=GF RT secretion protein BipB.
#=GF RA Suparak S, Kespichayawattana W, Haque A, Easton A, Damnin S,
#=GF RA Lertmemongkolchai G, Bancroft GJ, Korbsrisate S;
#=GF RL J Bacteriol. 2005;187:6556-6560.
#=GF RN [7]
#=GF RM 22975346
#=GF RT Membrane topology of Salmonella invasion protein SipB confers
#=GF RT osmotolerance.
#=GF RA Asakura H, Ekawa T, Sugimoto N, Momose Y, Kawamoto K, Makino S,
#=GF RA Igimi S, Yamamoto S;
#=GF RL Biochem Biophys Res Commun. 2012;426:654-658.
#=GF RN [8]
#=GF RM 22321794
#=GF RT The structures of coiled-coil domains from type III secretion
#=GF RT system translocators reveal homology to pore-forming toxins.
#=GF RA Barta ML, Dickenson NE, Patil M, Keightley A, Wyckoff GJ,
#=GF RA Picking WD, Picking WL, Geisbrecht BV;
#=GF RL J Mol Biol. 2012;417:395-405.
#=GF DR INTERPRO; IPR032391;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC T3SSipB is a family of pathogenic Gram-negative bacterial
#=GF CC proteins that invade human intestinal cells via the type III
#=GF CC secretion system translocators. T3SSipB represents the coiled
#=GF CC -coil region of the proteins and is shown to be homologous in
#=GF CC activity to the pore-forming toxins of other Gram-negative
#=GF CC pathogens, such as colicin Ia [1-8].
#=GF SQ 23
#=GS A9MF89_SALAR/82-234 AC A9MF89.1
#=GS A0A4Z0LEJ9_SALET/82-234 AC A0A4Z0LEJ9.1
#=GS A0A2N8GPZ8_9PSED/83-235 AC A0A2N8GPZ8.1
#=GS A0A1N7SC18_9BURK/107-267 AC A0A1N7SC18.1
#=GS Q326S9_SHIDS/76-231 AC Q326S9.1
#=GS BIPB_BURPS/99-261 AC Q63K34.1
#=GS A0A4R1NFA6_9GAMM/95-246 AC A0A4R1NFA6.1
#=GS A0A0R0D4Y8_9GAMM/95-245 AC A0A0R0D4Y8.1
#=GS A0A1H2AC73_9PSED/79-238 AC A0A1H2AC73.1
#=GS A0A0X1T887_PSEAA/79-239 AC A0A0X1T887.1
#=GS A0A5E4TBS3_9BURK/81-232 AC A0A5E4TBS3.1
#=GS Q7NUS8_CHRVO/81-233 AC Q7NUS8.1
#=GS G8Q409_PSEF3/85-238 AC G8Q409.1
#=GS A0A4U2UGT3_9GAMM/94-245 AC A0A4U2UGT3.1
#=GS A0A4R3YYT3_9GAMM/98-251 AC A0A4R3YYT3.1
#=GS A0A2X4WDD8_SALER/1-121 AC A0A2X4WDD8.1
#=GS IPAB_SHIFL/76-231 AC P18011.2
#=GS IPAB_SHIFL/76-231 DR PDB; 5WKQ A; 76-231;
#=GS IPAB_SHIFL/76-231 DR PDB; 3U0C B; 76-224;
#=GS IPAB_SHIFL/76-231 DR PDB; 5WKQ B; 76-230;
#=GS IPAB_SHIFL/76-231 DR PDB; 3U0C A; 76-224;
#=GS A0A239S6G5_9BURK/83-235 AC A0A239S6G5.1
#=GS A0A3S4I3Q7_SALBN/82-234 AC A0A3S4I3Q7.1
#=GS A0A4Q2J256_9BURK/87-242 AC A0A4Q2J256.1
#=GS SIPB_SALTY/82-234 AC Q56019.1
#=GS SIPB_SALTY/82-234 DR PDB; 3TUL B; 83-227;
#=GS SIPB_SALTY/82-234 DR PDB; 3TUL D; 83-226;
#=GS SIPB_SALTY/82-234 DR PDB; 3TUL A; 82-226;
#=GS SIPB_SALTY/82-234 DR PDB; 3TUL C; 84-225;
#=GS A0A0J6RGR6_9NEIS/79-231 AC A0A0J6RGR6.1
#=GS A0A4R0Z222_9GAMM/80-232 AC A0A4R0Z222.1
A9MF89_SALAR/82-234 ......EGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKAMGLQVSKEFQAALGEAEKATDIYEESIKKMDTAKSVYDTAAKKLTQAQN.............KLQSMDPSDPGYAKA....EAAEGQAR--...KE.AK.DAKTAF.....DKAKKAADLAGTDAKTKTEQADNILTKFQGT-t................
A0A4Z0LEJ9_SALET/82-234 ......EGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKRVYAAAAKNLTQAQN.............NLQSLDPADPGYAQA....EAAVEQAG--...KE.AT.EAKEAL.....DKATDATLNAGTDAKAKAEKADNILTKFQGTA.................
A0A2N8GPZ8_9PSED/83-235 ...gdl---FTLLMAMISELIGEVDVKKLKNRLAMLQSMAGARQQGHEKLAAEYASAVEALEAAEGEIGSSQEHLDQLQERVRQVQGLLDKSEA.............RLAELDPESPEYARE....LALRDKLK--...GE.LA.GHTQTL.....QKATDAHLKLIEIANACAKTLAAVAVKVQE--ag...............
A0A1N7SC18_9BURK/107-267 ......AARLTQIVSDLMKLIGRGSLDELEKNAKLWHALSDAAKEQLENVSRAYKRAAQDAADAVAAAKDAADIAERARHEADAADKSAEEAKE.............QLDRAGNNHAPQAEL....DRLKAEWEKA...RDvAK.RADNTA.....HAAASRAEAAKQQAVDASNSAADAE-------savdsavinaqt.....
Q326S9_SHIDS/76-231 ......SSQLTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNLEFSDKINTLLSETEGLTRDYEKQINKLKNADSKIKDLENKINQIQT.............RLSELAPDSPEKKKL....RREEIQLTIK...KD.AA.VKDRTLi...eQKTLSIHSKLTDKSMQLEKEIDSFSA-FSNTA.................
BIPB_BURPS/99-261 ......AAKLTELLGVLMSVISASSLDELKQRSDIWNQMSKAAQDNLSRLSDAFQRATDEAKAAADAAEQAAAAAKQAGADAKAADAAVDAAQKryddavkqglpddRLQSL------KAAL....EQARQQAGDAhgrAD.AL.QADA--.....TKKLDAASALATQARACEQQVDDAVNQATQQY.................
A0A4R1NFA6_9GAMM/95-246 ....sa--VFTLLAGNAMMLLGNHSLVQLADRLQIIQANSEALQQANEALAQQFQQAVDSSAAALSAAEADSASLQTAQNSLAEKQENYDQAKN.............RLDLLSPEDPEYTAAlsrfESAERELSDA..aRD.VA.QAQVKA.....GESYQAA-------------------------resslllddlfrkmqgp
A0A0R0D4Y8_9GAMM/95-245 ...slr----TWALGELQQSLGKQGFDHIEQRRHTHRSTLDARVQRAEHLSAEMRAALDAATAAQDAAEAAAGEVGAEQGALEAAREHVQQLQS.............ELDALQPNDPARAAK....-QEELAAA--...RE.VL.QQAQ--.....QRFDAAAQALCEAALELDA-------------klgeldeleatlrgf..
A0A1H2AC73_9PSED/79-238 ....eg--EFVRLIASLVELLGNTSLETLKNRLSLLRSVAQASQQSLQRLSADYAQSLAELAAAQGAVDSSQERLEALKARLDQAQFELEAAES.............HLASLDPSSPEYAGA....LARRDRAMGV...VD.TL.QQGFRPvaeahVRLLDTAKVAAVKAEALVRQIQDLA-------vrhpatd..........
A0A0X1T887_PSEAA/79-239 ....eg--EFVRLIASLIELLGNANLESLKNRLSMLRAVTQSSQQGLDRLSADYKQALGELVAAQGAVDTSQEQLQLLKDRLDQAQIELEAAES.............HLASLDPSSPEYADA....LARRDAAKAA...LG.GL.QQG--F.....EAALKAHLGLLATAKSVAIRTEALARQVQ---aagidgkvvdq......
A0A5E4TBS3_9BURK/81-232 ......AGALTEMLTRLVDQLGTSSLAAIDARLAAWQAKNDVRSNAGEKLSAEYEAAKQGVSDAIAAYEDALKALADAIAQAKAAQDRVDKLRG.............ERDALTPGTLAYDAA....MQKHETAM--...QS.AA.QAENAV.....AARRAEAERAQTAAAAAVNAADKLLN------dglnt............
Q7NUS8_CHRVO/81-233 ......AGKLTLLLGQLMSLLGNVSLSQLESRIATWRAMMEAQVAMGEKLSQEFQDAFKAASEATEALKDAVGNYDSAKQAADAAQKKADAAQA.............KVDGMSPDEPGYAEA....QAASQQAA--...AD.AL.QAKQKA.....DKAYDAAEKARVVAVEKGKVADDLAGKVQGAN.................
G8Q409_PSEF3/85-238 ..sgdl---FTLLMAMISELIGEVDVKKLKNRLAMLQSMAGARQQGHENLSAEYAAAVEAMAAAEGNVGSSQEHLDQLQERVLHFQALLQESEV.............RLAQLDPESPEYAQE....LALRDQLR--...GD.VA.SHTQTL.....QTATAAHLKLIEVANACARTVTAVVAKMQE--ss...............
A0A4U2UGT3_9GAMM/94-245 .....t-ARFTQLAGNAMRLLGNASLSQLASRLEVMMANSHALQQRNEALYMQFQQAAEHSTAATAQAEADLASLDAAAQQLADKQQAYDQAKL.............ALSQLAPQDPGYEAA....YGQLQTA---...EL.ALnQAREQW.....GKAESLAQQSYAAAREAVLAVDDLLI------rlesl............
A0A4R3YYT3_9GAMM/98-251 nasfvk------VMSDLMVLLGSISLADLAGRLKIFQSAANAKKQHNEARAAEYDKAVKANETALKNAQADMDAANADKGDLAQRQQSVKDCEA.............ALQKLKPGDPAYPQA....EKKLQQAQKR..eAL.AV.GKYRQA.....QQKADASYQVARDAFSKLDQLDK---------qiraddk..........
A0A2X4WDD8_SALER/1-121 ......--------------------------------MIESQKAMGLQVSKEFQAALEEAEKATDIYEESIKKMDTAKSVYDTAAKKLTQAQN.............KLQSMDPSDPGYAKA....EAAEGQAR--...KE.AK.DAKTAF.....DKAKKAADLAGTDAKTKTEQADNILTKFQGT-t................
IPAB_SHIFL/76-231 ......SSQLTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNLEFSDKINTLLSETEGLTRDYEKQINKLKNADSKIKDLENKINQIQT.............RLSELDPESPEKKKL....SREEIQLTIK...KD.AA.VKDRTLi...eQKTLSIHSKLTDKSMQLEKEIDSFSA-FSNTA.................
#=GR IPAB_SHIFL/76-231 SS ......HHHHHHHHHHHHHHH-SGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.............HHHCS-SS-SHHHHH....HHHHHHHHHH...HH.HH.HHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHCHHH-HHHHS.................
A0A239S6G5_9BURK/83-235 .....r-ASLTYLLGRLTELFSHSSLSDLQNRLKQSQLEAASRQAMAEQSQAEFDQAVAAATQAMDALDQATQHLADAEQALANAQETLTNTKA.............ALDSATPGTPEYDAA....MQAYEAAKSG...YD.AA.KARH--.....DQAKHEATQAFEAAKDATRKADDILGKFLG--nq...............
A0A3S4I3Q7_SALBN/82-234 ......EGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQSALGEAQEATDLYEASIKKTDTAKSVYDAAAKKLTQAQN.............KLQSLDPADPSYAQA....EAAVEQAG--...KE.AT.EAKEAL.....DKAADATVKAGTDAKAKAEKADSILTKFQGTA.................
A0A4Q2J256_9BURK/87-242 .....g-ATLMLLLGQLNELLGLAGMTELNTRIAAFKEAAEARSAALAEGAEKFSDAVTVADAAVTAYAGGKEQAAAARAAMDGAQAEAAAAEA.............ELQALEEGDPARPQA....MHKFEAAQ--...KT.LT.AATQKY.....AGAVENEKRLSDDVVQKVRIAADL--------ekkamadgaas......
SIPB_SALTY/82-234 ......EGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKSVYDAATKKLTQAQN.............KLQSLDPADPGYAQA....EAAVEQAG--...KE.AT.EAKEAL.....DKATDATVKAGTDAKAKAEKADNILTKFQGTA.................
#=GR SIPB_SALTY/82-234 SS ......XXCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHTTTTT----STHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.............HHTT---------CH....HHHHHHHH--...HH.HH.HHHHHH.....HHHHHHHHHHHHHHHHHHHHHHTXXXXXXXXX.................
A0A0J6RGR6_9NEIS/79-231 ......AGKLTLLLGQLMSLLGNVSLSQLESRIATWRAMMEAQVAMGEKLSKEFQDAFKAASEATEALKDAVGNYDSAKQAADAAQKKADAALA.............KLNGMSPDDPGYADA....QAASQQAS--...GE.AA.QAKQKA.....DKASEVAEKARVVAVEKGKIADDLAGKVQGAN.................
A0A4R0Z222_9GAMM/80-232 .....l-ARLRELMGEFSGVVDGARGAKLRGDLLIWLDRQKTRQGVLDQLSSKFRGASDAYRDALDELTRRGKAVQAAADEANRLSREVGRLKD.............LLQGLSPDDPKRAEL....EGALAAAR--...RD.AG.QATQSL.....DVALKRLQDGVDKAEHAAKDVDALSDAV----rhes.............
#=GC SS_cons ......HHCHHHHHHHHHHHHHCHCHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.............HHCCS-SS-SHHHCH....HHHHHHHHHH...HH.HH.HHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHCHHHXHHHHS.................
#=GC seq_cons .......upLThLlGpLhpLLGssSLspLcsRLshapuhtcAppptspplSp-apsAlstupsApcsh-suhcphcsAcsthcsAppclspAps.............+LsuLsPscPtYApA....putpppAp.....p-.As.pAcpth.....s+AtcssppstssAtstscpsDslhs.h....t................
//
