#=GF ID TBPIP
#=GF AC PF07106.16
#=GF DE TBPIP/Hop2 winged helix domain
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE Pfam-B_14830 (release 10.0)
#=GF GA 22.80 22.80;
#=GF TC 22.80 22.80;
#=GF NC 22.70 22.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0123
#=GF RN [1]
#=GF RM 10806355
#=GF RT Molecular cloning and characterization of a human homologue of
#=GF RT TBPIP, a BRCA1 locus-related gene.
#=GF RA Ijichi H, Tanaka T, Nakamura T, Yagi H, Hakuba A, Sato M;
#=GF RL Gene 2000;248:99-107.
#=GF RN [2]
#=GF RM 9708739
#=GF RT The meiosis-specific Hop2 protein of S. cerevisiae ensures
#=GF RT synapsis between homologous chromosomes.
#=GF RA Leu JY, Chua PR, Roeder GS;
#=GF RL Cell. 1998;94:375-386.
#=GF RN [3]
#=GF RM 11447128
#=GF RT A novel meiosis-specific protein of fission yeast, Meu13p,
#=GF RT promotes homologous pairing independently of homologous
#=GF RT recombination.
#=GF RA Nabeshima K, Kakihara Y, Hiraoka Y, Nojima H;
#=GF RL EMBO J. 2001;20:3871-3881.
#=GF RN [4]
#=GF RM 15192114
#=GF RT Positive role of the mammalian TBPIP/HOP2 protein in
#=GF RT DMC1-mediated homologous pairing.
#=GF RA Enomoto R, Kinebuchi T, Sato M, Yagi H, Shibata T, Kurumizaka H,
#=GF RA Yokoyama S;
#=GF RL J Biol Chem. 2004;279:35263-35272.
#=GF RN [5]
#=GF RM 9345291
#=GF RT Molecular cloning and characterization of a novel TBP-1
#=GF RT interacting protein (TBPIP):enhancement of TBP-1 action on Tat
#=GF RT by TBPIP.
#=GF RA Tanaka T, Nakamura T, Takagi H, Sato M;
#=GF RL Biochem Biophys Res Commun. 1997;239:176-181.
#=GF DR INTERPRO; IPR010776;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This family consists of several eukaryotic TBP-1 interacting
#=GF CC protein (TBPIP) sequences. TBP-1 has been demonstrated to
#=GF CC interact with the human immunodeficiency virus type 1 (HIV-1)
#=GF CC viral protein Tat, then modulate the essential replication
#=GF CC process of HIV. In addition, TBP-1 has been shown to be a
#=GF CC component of the 26S proteasome, a basic multiprotein complex
#=GF CC that degrades ubiquitinated proteins in an ATP-dependent
#=GF CC fashion. Human TBPIP interacts with human TBP-1 then modulates
#=GF CC the inhibitory action of human TBP-1 on HIV-Tat-mediated
#=GF CC transactivation [1]. TBPIP was found to be an activator that
#=GF CC specifically stimulates the homologous pairing catalyzed by
#=GF CC DMC1. Family members also include yeast homologous-pairing
#=GF CC protein 2 (Hop2) and its homologues from animals and plants.
#=GF CC They are required for proper homologous pairing and efficient
#=GF CC cross-over and intragenic recombination during meiosis [2, 3, 4,
#=GF CC 5].
#=GF SQ 1297
#=GS A0A6J1HWT5_CUCMA/7-69 AC A0A6J1HWT5.1
#=GS A0A6P6V981_COFAR/7-69 AC A0A6P6V981.1
#=GS A0A6I8U2Y6_AEDAE/8-68 AC A0A6I8U2Y6.1
#=GS A0A023BA90_GRENI/3-56 AC A0A023BA90.1
#=GS M3CX20_SPHMS/19-80 AC M3CX20.1
#=GS E5A3K7_LEPMJ/15-76 AC E5A3K7.1
#=GS A0A669DDT2_ORENI/15-77 AC A0A669DDT2.1
#=GS A0A7N9AUJ2_9TELE/6-69 AC A0A7N9AUJ2.1
#=GS A0A383UV75_BLUGH/86-138 AC A0A383UV75.1
#=GS A0A1I7VD91_LOALO/16-77 AC A0A1I7VD91.1
#=GS T1FXU5_HELRO/11-72 AC T1FXU5.1
#=GS A0A165KT84_9APHY/6-58 AC A0A165KT84.1
#=GS A0A5N5SKK5_9CRUS/6-67 AC A0A5N5SKK5.1
#=GS A0A0L0G0A6_9EUKA/450-512 AC A0A0L0G0A6.1
#=GS A0A2C9UKF1_MANES/7-69 AC A0A2C9UKF1.1
#=GS M7BTH7_CHEMY/11-44 AC M7BTH7.1
#=GS B0D8R8_LACBS/1-50 AC B0D8R8.1
#=GS A0A6A5LUB7_LUPAL/7-69 AC A0A6A5LUB7.1
#=GS A0A7C8MJW1_9PLEO/15-76 AC A0A7C8MJW1.1
#=GS A0A6J1HXK8_CUCMA/20-74 AC A0A6J1HXK8.1
#=GS A0A1V9YSU8_9STRA/99-160 AC A0A1V9YSU8.1
#=GS A0A1U8BNR4_MESAU/11-74 AC A0A1U8BNR4.1
#=GS A0A0K9Q345_ZOSMR/7-69 AC A0A0K9Q345.1
#=GS J9DKK0_EDHAE/314-375 AC J9DKK0.1
#=GS A0A0C3CMR1_HEBCY/1-50 AC A0A0C3CMR1.1
#=GS A0A2J6L425_LACSA/7-69 AC A0A2J6L425.1
#=GS A0A2Y9JUQ8_ENHLU/11-74 AC A0A2Y9JUQ8.1
#=GS A0A6I9YWB8_9SAUR/13-76 AC A0A6I9YWB8.1
#=GS A0A7N8Y763_9TELE/6-69 AC A0A7N8Y763.1
#=GS A0A0D3C9E7_BRAOL/49-111 AC A0A0D3C9E7.1
#=GS W5N3W0_LEPOC/8-71 AC W5N3W0.1
#=GS A0A4S3ZY04_9FLAO/13-64 AC A0A4S3ZY04.1
#=GS C1MPP9_MICPC/1-62 AC C1MPP9.1
#=GS A0A0U5G4M7_9EURO/19-79 AC A0A0U5G4M7.1
#=GS A0A3N4L8J5_9PEZI/15-76 AC A0A3N4L8J5.1
#=GS A0A673B9L7_9TELE/2-65 AC A0A673B9L7.1
#=GS A0A653DGR2_CALMS/1-64 AC A0A653DGR2.1
#=GS A0A453H6W6_AEGTS/6-67 AC A0A453H6W6.1
#=GS A0A165VQD7_9AGAM/1-50 AC A0A165VQD7.1
#=GS A0A699ZWU7_HAELA/6-65 AC A0A699ZWU7.1
#=GS K4AEQ4_SETIT/7-69 AC K4AEQ4.1
#=GS A0A498L5E6_LABRO/7-70 AC A0A498L5E6.1
#=GS A0A2K5YXT6_MANLE/11-74 AC A0A2K5YXT6.1
#=GS A0A151I4C8_9HYME/1-62 AC A0A151I4C8.1
#=GS S9XKI3_CAMFR/11-74 AC S9XKI3.1
#=GS A0A135L9T0_PENPA/20-76 AC A0A135L9T0.1
#=GS A0A368GE36_ANCCA/52-113 AC A0A368GE36.1
#=GS A0A6P7ZEM8_9AMPH/8-71 AC A0A6P7ZEM8.1
#=GS A0A2Y9EHR2_PHYMC/11-74 AC A0A2Y9EHR2.1
#=GS A0A562JH95_9FIRM/2-60 AC A0A562JH95.1
#=GS A0A2P6R1T2_ROSCH/7-69 AC A0A2P6R1T2.1
#=GS A0A2K5P183_CERAT/11-74 AC A0A2K5P183.1
#=GS A0A7I4CR99_PHYPA/1-43 AC A0A7I4CR99.1
#=GS A0A409XX42_9AGAR/1-50 AC A0A409XX42.1
#=GS H0Y0T6_OTOGA/11-74 AC H0Y0T6.1
#=GS A0A0R3TQY0_RODNA/1-53 AC A0A0R3TQY0.1
#=GS A0A072UEX6_MEDTR/7-69 AC A0A072UEX6.1
#=GS B6AE56_CRYMR/113-174 AC B6AE56.1
#=GS A0A484DZL4_BRELC/96-157 AC A0A484DZL4.1
#=GS A0A1X2IT77_9FUNG/12-72 AC A0A1X2IT77.1
#=GS A0A0J8RSU1_COCIT/18-70 AC A0A0J8RSU1.1
#=GS A0A668SZF3_OREAU/6-69 AC A0A668SZF3.1
#=GS W4KDS4_HETIT/1-50 AC W4KDS4.1
#=GS A0A0D8Y8H6_DICVI/9-42 AC A0A0D8Y8H6.1
#=GS A0A2I3RLK0_PANTR/11-74 AC A0A2I3RLK0.1
#=GS A0A0L9UTJ7_PHAAN/7-69 AC A0A0L9UTJ7.1
#=GS A0A1E3IVZ8_9TREE/16-77 AC A0A1E3IVZ8.1
#=GS A0A6P9EPA7_JUGRE/1-39 AC A0A6P9EPA7.1
#=GS K7ELD8_HUMAN/11-74 AC K7ELD8.1
#=GS A0A6J1HZ82_CUCMA/7-69 AC A0A6J1HZ82.1
#=GS A0A0C9T3R6_PLICR/17-78 AC A0A0C9T3R6.1
#=GS A0A0B1P327_UNCNE/78-130 AC A0A0B1P327.1
#=GS A0A3B5Q9J9_XIPMA/6-69 AC A0A3B5Q9J9.1
#=GS A0A6J2X024_CHACN/6-69 AC A0A6J2X024.1
#=GS A7ERG3_SCLS1/124-178 AC A7ERG3.1
#=GS F2SHM2_TRIRC/60-105 AC F2SHM2.2
#=GS A0A669D3M7_ORENI/6-69 AC A0A669D3M7.1
#=GS A0A7F8R8Z3_LEPWE/11-74 AC A0A7F8R8Z3.1
#=GS S8AXC5_PENO1/17-78 AC S8AXC5.1
#=GS H2XUK0_CIOIN/4-65 AC H2XUK0.1
#=GS F0ZLC9_DICPU/5-58 AC F0ZLC9.1
#=GS B6HEQ8_PENRW/9-68 AC B6HEQ8.1
#=GS A0A1Y2BHR4_9TREE/16-77 AC A0A1Y2BHR4.1
#=GS A0A6J3QP72_TURTR/11-74 AC A0A6J3QP72.1
#=GS A0A6P6BIP5_DURZI/7-69 AC A0A6P6BIP5.1
#=GS A0A2P6TXS6_CHLSO/2-39 AC A0A2P6TXS6.1
#=GS Q6BS19_DEBHA/15-76 AC Q6BS19.2
#=GS A0A1Y1I9S1_KLENI/30-94 AC A0A1Y1I9S1.1
#=GS E3RIF3_PYRTT/15-76 AC E3RIF3.1
#=GS A0A0D7AQI3_9AGAR/16-77 AC A0A0D7AQI3.1
#=GS A0A4C1Y6T3_EUMVA/1-62 AC A0A4C1Y6T3.1
#=GS A0A1L9V374_ASPBC/20-82 AC A0A1L9V374.1
#=GS M2ZFD0_PSEFD/19-79 AC M2ZFD0.1
#=GS A0A2T3ARW6_AMORE/68-120 AC A0A2T3ARW6.1
#=GS A0A3P6T6C8_LITSI/38-99 AC A0A3P6T6C8.1
#=GS A0A3Q7GFI7_SOLLC/37-92 AC A0A3Q7GFI7.1
#=GS A0A0E0GSL9_ORYNI/954-1009 AC A0A0E0GSL9.1
#=GS A0A7D8YTE4_9HELO/106-158 AC A0A7D8YTE4.1
#=GS A4I343_LEIIN/16-77 AC A4I343.1
#=GS A0A1L9TQF7_9EURO/18-79 AC A0A1L9TQF7.1
#=GS A0A2T7P8P2_POMCA/125-186 AC A0A2T7P8P2.1
#=GS A0A3Q3XPX1_MOLML/13-67 AC A0A3Q3XPX1.1
#=GS A0A427YHX4_9TREE/16-77 AC A0A427YHX4.1
#=GS A0A1U7SS88_CARSF/11-74 AC A0A1U7SS88.1
#=GS A0A7E5VJ44_TRINI/1-62 AC A0A7E5VJ44.1
#=GS A0A0Q3R0X4_AMAAE/13-76 AC A0A0Q3R0X4.1
#=GS A0A3Q7W621_URSAR/11-74 AC A0A3Q7W621.1
#=GS G4VQ39_SCHMA/5-65 AC G4VQ39.1
#=GS A0A4S2MUQ2_9PEZI/15-76 AC A0A4S2MUQ2.1
#=GS A0A6P3EXF5_OCTDE/10-73 AC A0A6P3EXF5.1
#=GS A0A665VMT7_ECHNA/6-69 AC A0A665VMT7.1
#=GS A0A6J0X1D2_ODOVR/11-74 AC A0A6J0X1D2.1
#=GS A0A1V8UEM4_9PEZI/20-81 AC A0A1V8UEM4.1
#=GS B9HJ11_POPTR/7-69 AC B9HJ11.1
#=GS G7XFK3_ASPKW/20-69 AC G7XFK3.1
#=GS A0A370TC02_9HELO/91-143 AC A0A370TC02.1
#=GS A0A6P3WNI9_DINQU/1-62 AC A0A6P3WNI9.1
#=GS A0A1R2BWV6_9CILI/104-165 AC A0A1R2BWV6.1
#=GS A0A669D6Q7_ORENI/6-69 AC A0A669D6Q7.1
#=GS A0A6I9WUY1_9HYME/1-62 AC A0A6I9WUY1.1
#=GS B6TAH2_MAIZE/7-69 AC B6TAH2.1
#=GS A0A0C2MEU5_THEKT/8-81 AC A0A0C2MEU5.1
#=GS A0A5N5XAZ2_9EURO/1-59 AC A0A5N5XAZ2.1
#=GS A0A1V4JQQ4_PATFA/12-75 AC A0A1V4JQQ4.1
#=GS Q01AX2_OSTTA/1-63 AC Q01AX2.1
#=GS A0A6A3CQJ8_HIBSY/7-69 AC A0A6A3CQJ8.1
#=GS A0A067MH93_9AGAM/6-67 AC A0A067MH93.1
#=GS U6KDG5_9EIME/43-104 AC U6KDG5.1
#=GS A0A1X7RA10_9SACH/14-75 AC A0A1X7RA10.1
#=GS A0A3L8Q6M2_CHLGU/12-75 AC A0A3L8Q6M2.1
#=GS C5FZW4_ARTOC/37-85 AC C5FZW4.1
#=GS A0A493SXC6_ANAPP/14-77 AC A0A493SXC6.1
#=GS A8BZF2_GIAIC/7-69 AC A8BZF2.1
#=GS A0A2G2W3V1_CAPBA/48-104 AC A0A2G2W3V1.1
#=GS A0A0D7BLN8_9AGAR/1-45 AC A0A0D7BLN8.1
#=GS A0A0D9S1R5_CHLSB/11-74 AC A0A0D9S1R5.1
#=GS A0A1B9IC80_9TREE/16-77 AC A0A1B9IC80.1
#=GS A0A4S8IXY9_MUSBA/7-69 AC A0A4S8IXY9.1
#=GS A0A183T9P0_SCHSO/1-53 AC A0A183T9P0.1
#=GS A0A0G4FU35_VITBC/132-193 AC A0A0G4FU35.1
#=GS A0A484GW25_SOUCH/11-74 AC A0A484GW25.1
#=GS A0A7F5RN36_AGRPL/1-62 AC A0A7F5RN36.1
#=GS W6YUW1_COCCA/15-76 AC W6YUW1.1
#=GS C5GM89_AJEDR/18-79 AC C5GM89.2
#=GS A0A2I2Y431_GORGO/11-74 AC A0A2I2Y431.1
#=GS W6UNE3_ECHGR/14-74 AC W6UNE3.1
#=GS A0A0L1IER7_PLAFA/455-516 AC A0A0L1IER7.1
#=GS A0A3S1I096_ELYCH/8-69 AC A0A3S1I096.1
#=GS A0A199UHM3_ANACO/7-69 AC A0A199UHM3.1
#=GS A0A3R7IL45_9EURO/18-82 AC A0A3R7IL45.1
#=GS A0A1D8PMI3_CANAL/13-74 AC A0A1D8PMI3.1
#=GS A0A0N5CPD2_THECL/9-50 AC A0A0N5CPD2.1
#=GS A0A072UQ55_MEDTR/21-70 AC A0A072UQ55.1
#=GS A0A1E4RK13_9ASCO/17-78 AC A0A1E4RK13.1
#=GS A0A446RRT4_TRITD/7-69 AC A0A446RRT4.1
#=GS A0A3P9D712_9CICH/6-69 AC A0A3P9D712.1
#=GS A0A6P6N4Q5_CARAU/7-70 AC A0A6P6N4Q5.1
#=GS R0MI60_NOSB1/157-212 AC R0MI60.1
#=GS A0A6P7SVF1_OCTVU/6-67 AC A0A6P7SVF1.1
#=GS A0A218ZCD8_9HELO/102-154 AC A0A218ZCD8.1
#=GS A0A1Q9C7G7_SYMMI/756-817 AC A0A1Q9C7G7.1
#=GS A0A7N6AXH7_ANATE/7-69 AC A0A7N6AXH7.1
#=GS F0P214_WEEVC/35-95 AC F0P214.1
#=GS C9RC43_AMMDK/378-432 AC C9RC43.1
#=GS A0A060YC91_ONCMY/7-69 AC A0A060YC91.1
#=GS A0A444TGL8_ARMVU/6-67 AC A0A444TGL8.1
#=GS A0A453H6W9_AEGTS/14-76 AC A0A453H6W9.1
#=GS A0A6I8NPG0_ORNAN/10-73 AC A0A6I8NPG0.1
#=GS A0A1U8LZ61_GOSHI/7-69 AC A0A1U8LZ61.1
#=GS A0A433DG68_9FUNG/16-56 AC A0A433DG68.1
#=GS A0A151PBL9_ALLMI/13-76 AC A0A151PBL9.1
#=GS A0A2G3B691_CAPCH/7-69 AC A0A2G3B691.1
#=GS A0A2I0RZ64_9PEZI/658-719 AC A0A2I0RZ64.1
#=GS A0A1E5R6Y3_HANUV/14-75 AC A0A1E5R6Y3.1
#=GS A0A4Y7JEF2_PAPSO/7-69 AC A0A4Y7JEF2.1
#=GS A0A151PBX8_ALLMI/13-76 AC A0A151PBX8.1
#=GS A0A1B9GYL0_9TREE/2-47 AC A0A1B9GYL0.1
#=GS A0A0R3W103_TAEAS/5-65 AC A0A0R3W103.1
#=GS A0A4Q9L2K1_9MICR/17-77 AC A0A4Q9L2K1.1
#=GS A0A2K5DJX2_AOTNA/11-74 AC A0A2K5DJX2.1
#=GS A0A444F5M4_ENSVE/1-52 AC A0A444F5M4.1
#=GS I4YF47_WALMC/10-74 AC I4YF47.1
#=GS A0A0S7DHM5_9EURO/19-82 AC A0A0S7DHM5.1
#=GS A0A5A8CNI8_CAFRO/141-202 AC A0A5A8CNI8.1
#=GS A0A5C3MN02_9AGAM/6-72 AC A0A5C3MN02.1
#=GS A0A067PUL9_9AGAM/1-50 AC A0A067PUL9.1
#=GS F7BQN1_HORSE/11-74 AC F7BQN1.1
#=GS A0A059J0A3_TRIIM/1-58 AC A0A059J0A3.1
#=GS A0A0C9XAJ0_9AGAR/1-50 AC A0A0C9XAJ0.1
#=GS H0W6E6_CAVPO/11-74 AC H0W6E6.1
#=GS M0RHA4_MUSAM/7-69 AC M0RHA4.1
#=GS A0A1Y1VDM7_9FUNG/12-73 AC A0A1Y1VDM7.1
#=GS M4DTI2_BRARP/7-69 AC M4DTI2.1
#=GS E1EW28_GIAIA/7-69 AC E1EW28.1
#=GS A0A6I8MFH2_9FUSO/226-286 AC A0A6I8MFH2.1
#=GS A0A6P6ENX5_OCTDE/10-73 AC A0A6P6ENX5.1
#=GS A0A0F7TJ93_PENBI/26-84 AC A0A0F7TJ93.1
#=GS A0A183KUZ4_9TREM/5-65 AC A0A183KUZ4.1
#=GS A0A0L0VTI9_9BASI/17-77 AC A0A0L0VTI9.1
#=GS A0A1M6J7A3_9CLOT/2-52 AC A0A1M6J7A3.1
#=GS A0A6D2JE90_9BRAS/7-69 AC A0A6D2JE90.1
#=GS F7FVR4_MONDO/12-75 AC F7FVR4.1
#=GS G0QR73_ICHMG/1-53 AC G0QR73.1
#=GS A0A1Q2YFW0_9ASCO/1-58 AC A0A1Q2YFW0.1
#=GS A0A5E4QAN3_9NEOP/1-62 AC A0A5E4QAN3.1
#=GS A0A166DCA8_9AGAM/16-77 AC A0A166DCA8.1
#=GS A0A2U9CTM5_SCOMX/497-559 AC A0A2U9CTM5.1
#=GS A0A1E4TRL1_PACTA/1-61 AC A0A1E4TRL1.1
#=GS A0A5M6C7N0_9TREE/16-77 AC A0A5M6C7N0.1
#=GS A0A5B8MN86_9CHLO/4-66 AC A0A5B8MN86.1
#=GS A0A6A6ME08_HEVBR/7-69 AC A0A6A6ME08.1
#=GS A0A165GJI3_EXIGL/16-62 AC A0A165GJI3.1
#=GS A0A6A3MAI6_9STRA/126-187 AC A0A6A3MAI6.1
#=GS A0A6P6EN20_OCTDE/10-73 AC A0A6P6EN20.1
#=GS K6UEF8_PLACD/399-460 AC K6UEF8.1
#=GS A0A1X6MMY0_9APHY/1-50 AC A0A1X6MMY0.1
#=GS A0A1Y1ZZW2_9PLEO/15-66 AC A0A1Y1ZZW2.1
#=GS A0A087HN93_ARAAL/7-69 AC A0A087HN93.1
#=GS A0A1S3BG80_CUCME/46-108 AC A0A1S3BG80.1
#=GS A0A364N6B0_9PLEO/776-829 AC A0A364N6B0.1
#=GS S8ARV9_DACHA/1-50 AC S8ARV9.1
#=GS A0A1X0SE01_RHIZD/13-74 AC A0A1X0SE01.1
#=GS G3V8N3_RAT/11-74 AC G3V8N3.1
#=GS A0A329RFD1_9STRA/114-175 AC A0A329RFD1.1
#=GS A9V6T0_MONBE/17-78 AC A9V6T0.1
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