GenomeNet

Database: Pfam
Entry: TPIP1
LinkDB: TPIP1
Original site: TPIP1 
#=GF ID   TPIP1
#=GF AC   PF15338.9
#=GF DE   p53-regulated apoptosis-inducing protein 1
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Jackhmmer:Q9HCN2
#=GF GA   27.00 27.00;
#=GF TC   32.10 31.60;
#=GF NC   23.40 20.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11030628
#=GF RT   p53AIP1, a potential mediator of p53-dependent apoptosis, and
#=GF RT   its regulation by Ser-46-phosphorylated p53.
#=GF RA   Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T,
#=GF RA   Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y;
#=GF RL   Cell. 2000;102:849-862.
#=GF DR   INTERPRO; IPR029284;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   TPIP1 is a family of eukaryotic proteins whose expression is
#=GF CC   induced by wild-type p53. Ectopically expressed TPIP1, which is
#=GF CC   localised within mitochondria, leads to apoptotic cell death
#=GF CC   through dissipation of mitochondrial A(psi)m. Phosphorylation of
#=GF CC   p53 Ser-46 regulates the transcriptional activation of TPIP1,
#=GF CC   thereby mediating p53-dependent apoptosis.
#=GF SQ   27
#=GS TPIP1_HUMAN/2-124       AC Q9HCN2.1
#=GS H2Q540_PANTR/2-124      AC H2Q540.1
#=GS A0A2K5XZ83_MANLE/2-119  AC A0A2K5XZ83.1
#=GS A0A2K6MAJ5_RHIBE/2-113  AC A0A2K6MAJ5.1
#=GS A0A2R9AIP3_PANPA/2-124  AC A0A2R9AIP3.1
#=GS A0A2K6P1Z8_RHIRO/2-88   AC A0A2K6P1Z8.1
#=GS A0A2I3RA32_PANTR/2-86   AC A0A2I3RA32.1
#=GS A0A2K5IV63_COLAP/2-86   AC A0A2K5IV63.1
#=GS A0A2K5IUX6_COLAP/2-116  AC A0A2K5IUX6.1
#=GS A0A2I3GNZ4_NOMLE/1-123  AC A0A2I3GNZ4.1
#=GS A0A2K5UU87_MACFA/2-112  AC A0A2K5UU87.2
#=GS H2NFV2_PONAB/2-124      AC H2NFV2.1
#=GS G3RIT2_GORGO/2-124      AC G3RIT2.1
#=GS A0A6J3IE48_SAPAP/2-47   AC A0A6J3IE48.1
#=GS A0A2R9ANI0_PANPA/2-86   AC A0A2R9ANI0.1
#=GS A0A0D9S4L6_CHLSB/1-119  AC A0A0D9S4L6.1
#=GS A0A2K6MAH1_RHIBE/2-86   AC A0A2K6MAH1.1
#=GS A0A2K6P1Y5_RHIRO/2-86   AC A0A2K6P1Y5.1
#=GS A0A2K6BQ79_MACNE/2-118  AC A0A2K6BQ79.1
#=GS A0A2K5NC42_CERAT/2-119  AC A0A2K5NC42.1
#=GS A0A5F7ZLQ1_MACMU/2-54   AC A0A5F7ZLQ1.1
#=GS A0A2K6P1Z2_RHIRO/2-113  AC A0A2K6P1Z2.1
#=GS A0A2I3HTQ4_NOMLE/1-85   AC A0A2I3HTQ4.1
#=GS A0A2K5CPH3_AOTNA/2-117  AC A0A2K5CPH3.1
#=GS A0A2K5P8Q9_CEBIM/2-62   AC A0A2K5P8Q9.1
#=GS A0A096NCN8_PAPAN/2-119  AC A0A096NCN8.2
#=GS A0A2I2Y7M2_GORGO/2-86   AC A0A2I2Y7M2.1
TPIP1_HUMAN/2-124                  GSSSEASFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQT..HTP..GWVSDPLVLGA.QVHGGCRGIEALSVSSGSWSSATVWILTGLGLGLSRPFLPGATVLRDRPLGSAFELSYDQKKAPLRLQ..................
H2Q540_PANTR/2-124                 GSSSEASFRSAQASCSGARRQGPGRGDQSLSVMPPNGRAQT..HTP..GWVSDLLVLGA.QVHGGCRGIEALSVSSGSWSSATVWILTGLGLGLSRPFLPGATVLRDRPLGSAFELSYDQKKAPLRLQ..................
A0A2K5XZ83_MANLE/2-119             GSSSKASFRSAQASGSGARRQGLGRGDQSLSMMPPNGRAQT..HTP..DWGS-PRTLCL.QVHRRCRGREAPSVSSGSWSSATVWCLTDLGLGLSRPFFPGAAVLKDRPLG----LSYDPKKAPLRLQ..................
A0A2K6MAJ5_RHIBE/2-113             GSSSKASFRSAQASGSGARRQGLGRRDQSLSMMPPNGRTQT..HTP..DWGSPP-TLGL.QVHGGCRGREAPSVSSGAWSSATVWCLTGV------PFFPGASVLKDRPLG----LSYDQKKAPLRSQ..................
A0A2R9AIP3_PANPA/2-124             GSSSEASFRSAQASCSGARRQGPGRGDQSLSVMPPNGRAQT..HTP..GWVSDLLVLGA.QVHGGCRGIEALSVSSGSWSSATVWILTGLGLGLSRPFLPGATVLRDRPLGSAFELSYDQKKAPLRLQ..................
A0A2K6P1Z8_RHIRO/2-88              GSSSKASFRSAQASGSGARRQGLGRGDQSLSMMPPNGRTQT..HTP..DWGNGLLPAVAlRRLCSHRGADIPS-------------------------------------------------------fqtrqdpvtasvaldgag
A0A2I3RA32_PANTR/2-86              GSSSEASFRSAQASCSGARRQGPGRGDQSLSVMPPNGRAQT..HTP..GWVSDLLVLGA.QVHGGCRGIEALSVSSGSWSSATVWILT----------------------------------------vq................
A0A2K5IV63_COLAP/2-86              GSSSKASFRSAQASGSGARRQGLGRGDQSLSMMPPSGRAQT..HTP..DRVSGLLALGL.QVHGGCRGREAPSVSSGAWSSATVWCLT----------------------------------------vq................
A0A2K5IUX6_COLAP/2-116             GSSSKASFRSAQASGSGARRQGLGRGDQSLSMMPPSGRAQT..HTPdrGRPRSLLALGL.QVHGGCRGREAPSVSSGAWSSATVWCLTGV------PFFPGAAMLKDRPLG----LSYDQKKAPLRLQ..................
A0A2I3GNZ4_NOMLE/1-123             GSSSKASFRSAQASCRGARRQGLGRGDQSLLVMPPNGRAQT..HTP..GWVSGLLVLGP.QVHGGWRGIEAPSVSSGSWSSAAVWCLTGLGLGLSRPFLLGGTVLRDRPLGSACELSYDQKKAPLRLQ..................
A0A2K5UU87_MACFA/2-112             GSSSKASFRSAQASGSGARRQGLGRGDQSLSMMPPNGRAQT..HTL..DWGS-PCTLCL.QVHGRCRGREAPSVSSGSWSSATVWCLTDLGLGLSRPFFPGATVL-----------SCDQKKAPLRLQ..................
H2NFV2_PONAB/2-124                 GSSSKVSFRSAQASCSGTRRQGLGRGDQNLSVMLPNGRAQT..HTL..GWVSGLLVLGA.QVHGGCRGIEAPSVSSGSWSSATVWCLTGLGLGLSKPFLPGVIVLRDRPLESACELSYDQKKALLSLQ..................
G3RIT2_GORGO/2-124                 GSSPKVSFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQT..HTP..GWVSDLLVLGA.QVHGGCRGIEALSVSSGSWSSVTVWILTGLGLGLSRPFLPGATVLRDRPLGSAFELSYDQKKAPLRLQ..................
A0A6J3IE48_SAPAP/2-47              GSSPKASFRSAQASGGRARRQGLGWGDQX-----PRSDAQI..PAL..GW---------.--------------------------------------------------------------------eeprs.............
A0A2R9ANI0_PANPA/2-86              GSSSEASFRSAQASCSGARRQGPGRGDQSLSVMPPNGRAQT..HTP..GWVSDLLVLGA.QVHGGCRGIEALSVSSGSWSSATVWILT----------------------------------------vq................
A0A0D9S4L6_CHLSB/1-119             GSSSKASFRSAQASGSGARRQGLGRGDQSLSMMPPNSRAQT..HTP..DWISGLLALGL.QVHRGCRGREAPSVSSGSWSSATVWCLTGLGLGLSRPFFPGTTVLKDRPLGSAVSLSYDQKKAP----..................
A0A2K6MAH1_RHIBE/2-86              GSSSKASFRSAQASGSGARRQGLGRRDQSLSMMPPNGRTQT..HTP..DWVSGLLALGL.QVHGGCRGREAPSVSSGAWSSATVWCLT----------------------------------------vq................
A0A2K6P1Y5_RHIRO/2-86              GSSSKASFRSAQASGSGARRQGLGRGDQSLSMMPPNGRTQT..HTP..DWVSGLLALGL.QVHGGCRGREAPSVSSGAWSSATVWCLT----------------------------------------vq................
A0A2K6BQ79_MACNE/2-118             GSSSKASFRSAQASGGGARRQGLGRGDQSLSMMPPNGRAQT..HTL..DWGSPSFCL--.QVHGRCRGREAPSVSSGSWSSATVWCLTDLGLGLSRPFFPGATVLKDRPLG----LSCDQKKAPLRLQ..................
A0A2K5NC42_CERAT/2-119             GSSSKASFRSAQASGSGARRQGLGRGDQSLSMMPPNGRAQT..HTP..DWGS-PRTLCL.QVYGRCRGREAPSVSSGSWSSATVWCLTDLGLGLSRPFFPGAAVLKDRPLG----LSYDPKKAPLRLQ..................
A0A5F7ZLQ1_MACMU/2-54              GSSSKASFRSAQASGSGARRQGLGRGDQSLSMMPPNGRAQT..HTL..DWGS-------.--------------------------------------------------------------------pcsek.............
A0A2K6P1Z2_RHIRO/2-113             GSSSKASFRSAQASGSGARRQGLGRGDQSLSMMPPNGRTQT..HTP..DWGS-LLALGL.QVHGGCRGREAPSVSSGAWSSATVWCLTGV------PFFPGASVLKDRPLG----LSYNQKKAPLRSQ..................
A0A2I3HTQ4_NOMLE/1-85              GSSSKASFRSAQASCRGARRQGLGRGDQSLLVMPPNGRAQT..HTP..GWVSGLLVLGP.QVHGGWRGIEAPSVSSGSWSSAAVWCLT----------------------------------------vq................
A0A2K5CPH3_AOTNA/2-117             GSSPKANFRSAQASRGRARRQGLGWGDQKTS---PQGRALSpaSIS..SQVSGLFVFGP.RVHGGCRGIE-----SGSGSSATVWCLVGLGRGLSSPFLPGVTVLRDRLLGSACELSYDQKKST----rlq...............
A0A2K5P8Q9_CEBIM/2-62              GSSPKASFRSAQASGGRARRQGLGWGDQSPA--------LA..SIS..SQVSGLFVLGP.RVHGGCRGIEAPSV------------------------------------------------------..................
A0A096NCN8_PAPAN/2-119             GSSSKASFRSAQASGSGARRQGLGRGDQSLSMMPPNGRAQT..HTP..DWGS-PCTLCL.QVHGRCRGREAPSVSSGSWSSATVWCLTDLGLGLSRPFFPGTTVLKDRPLG----LSYDQKKAPLRLQ..................
A0A2I2Y7M2_GORGO/2-86              GSSPKVSFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQT..HTP..GWVSDLLVLGA.QVHGGCRGIEALSVSSGSWSSVTVWILT----------------------------------------vq................
#=GC seq_cons                      GSSSKASFRSAQASsSGARRQGLGRGDQSLShMPPNGRAQT..HTP..sWsSsLLsLGh.QVHGGCRGhEAPSVSSGSWSSATVWhLT..........................................................
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