#=GF ID TRA2_C
#=GF AC PF27573.1
#=GF DE Transformer protein 2 C-terminal domain
#=GF AU Morveli N;0000-0003-2496-881X
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE ECOD:P34709_TED05
#=GF GA 27.00 27.00;
#=GF TC 28.80 27.40;
#=GF NC 23.10 19.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 90746521 --cpu 8 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 11124807
#=GF RT Direct protein-protein interaction between the intracellular
#=GF RT domain of TRA-2 and the transcription factor TRA-1A modulates
#=GF RT feminizing activity in C. elegans.
#=GF RA Lum D.H., Kuwabara P.E., Zarkower D., Spence A.M.;
#=GF RL Genes Dev. 2000;14:3153-3165.
#=GF RN [2]
#=GF RM 11250902
#=GF RT The TRA-1 transcription factor binds TRA-2 to regulate sexual
#=GF RT fates in Caenorhabditis elegans.
#=GF RA Wang S., Kimble J.;
#=GF RL EMBO J. 2001;20:1363-1372.
#=GF RN [3]
#=GF RM 10364161
#=GF RT Negative regulation of male development in Caenorhabditis
#=GF RT elegans by a protein-protein interaction between TRA-2A and
#=GF RT FEM-3.
#=GF RA Mehra A., Gaudet J., Heck L., Kuwabara P.E., Spence A.M.;
#=GF RL Genes Dev. 1999;13:1453-1463.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This entry represents the C-terminal intracellular domain of the
#=GF CC transformer protein 2 (TRA-2) from Caenorhabditis elegans. This
#=GF CC domain contains the MX regulatory region (residues 1392-1413)
#=GF CC which is required for binding to the TRA-1 transcription factor
#=GF CC and mediates post-translational regulation essential for
#=GF CC hermaphrodite spermatogenesis. The domain also contains a region
#=GF CC (residues 1133-1273) involved in interaction with FEM-3 protein.
#=GF CC The C-terminal domain is produced as a separate isoform (TRA-2B)
#=GF CC through cleavage by TRA-3 protease, which generates a feminising
#=GF CC cytoplasmic form lacking the N-terminal membrane-spanning
#=GF CC regions.
#=GF SQ 34
#=GS A0A9P1AY46_9PELO/149-211 AC A0A9P1AY46.1
#=GS A0A8R1HXW0_CAEJA/423-485 AC A0A8R1HXW0.1
#=GS G0N1X1_CAEBE/275-339 AC G0N1X1.1
#=GS A0A261BFQ5_9PELO/1589-1652 AC A0A261BFQ5.1
#=GS A0A8R1DUA6_CAEJA/113-179 AC A0A8R1DUA6.1
#=GS A0A2G5V0Q7_9PELO/1316-1379 AC A0A2G5V0Q7.1
#=GS A0A2G5SDP2_9PELO/384-448 AC A0A2G5SDP2.1
#=GS A0A9P1AVY7_9PELO/350-406 AC A0A9P1AVY7.1
#=GS G8JY28_CAEEL/268-331 AC G8JY28.1
#=GS Q20791_CAEEL/70-131 AC Q20791.2
#=GS E3MJK7_CAERE/297-362 AC E3MJK7.1
#=GS A0A2G5SZE5_9PELO/293-359 AC A0A2G5SZE5.1
#=GS TRA2_CAEBR/1366-1429 AC Q17307.3
#=GS B6IG15_CAEBR/368-432 AC B6IG15.1
#=GS A0A2G5V006_9PELO/1290-1353 AC A0A2G5V006.1
#=GS TRA2_CAEEL/1356-1419 AC P34709.1
#=GS A0A131MBZ9_CAEEL/395-454 AC A0A131MBZ9.1
#=GS G0N9M8_CAEBE/1306-1370 AC G0N9M8.1
#=GS G0MBG9_CAEBE/338-404 AC G0MBG9.1
#=GS E3MP33_CAERE/186-262 AC E3MP33.1
#=GS A0A9P1ADK1_9PELO/1421-1482 AC A0A9P1ADK1.1
#=GS E3MLM0_CAERE/95-158 AC E3MLM0.1
#=GS E3LQQ1_CAERE/1379-1442 AC E3LQQ1.1
#=GS A0A9P1AXK7_9PELO/329-392 AC A0A9P1AXK7.1
#=GS E3MLR4_CAERE/250-313 AC E3MLR4.1
#=GS G0MB02_CAEBE/376-440 AC G0MB02.1
#=GS A0A261CHW5_9PELO/93-156 AC A0A261CHW5.1
#=GS A0A261CP56_9PELO/349-415 AC A0A261CP56.1
#=GS A0A8R1HV24_CAEJA/407-469 AC A0A8R1HV24.1
#=GS A0A261B266_9PELO/220-256 AC A0A261B266.1
#=GS A0A131MD22_CAEEL/360-419 AC A0A131MD22.1
#=GS A8WZJ9_CAEBR/293-332 AC A8WZJ9.2
#=GS A0A2G5UZY8_9PELO/332-395 AC A0A2G5UZY8.1
#=GS A0A261C047_9PELO/188-263 AC A0A261C047.1
A0A9P1AY46_9PELO/149-211 .......PPILSHYLESPE...-FKNGP..HPKAAWYPEDYSAGMVAYCLDPYFYvNVCVPPPADLLIPPLPK----gfi..............
A0A8R1HXW0_CAEJA/423-485 .......PPNVDEFVELFY...-GITER..HPRADQYPASFSRAMIEYCEDPYWT.RRTVPLPRGVTVPPRPSDYYH.................
G0N1X1_CAEBE/275-339 .......PPILEEIIDQST..sIPLEMRtkHRSAGCWPDNWPYEMVEYASDIFWW.N-QRPVPKGYLIPPKPV----qee..............
A0A261BFQ5_9PELO/1589-1652 .......PPNIHECIQHNT...DPTLPP..HPRRSQYPDHYGRAMICYCEDVYWT.YNDGRLPPNVVMPPRPRDWHH.................
A0A8R1DUA6_CAEJA/113-179 .......PPVMEEIIQANDpilYPNLGR..HPRADQYPANFSRAMVAYAEDPFWT.QRIVPLPPDIPVPPRPRDYF-i................
A0A2G5V0Q7_9PELO/1316-1379 .......PPSMEEYVQKYD...DPNQPS..SRRADQYPPSFTPAMVGYCEDVYWK.YNERNLPDNVPMPPRPRDWDQ.................
A0A2G5SDP2_9PELO/384-448 .......PPIMMEMNENEL..vSPHTEP..HPRADKYPPGFSYAMIEYCEDPFWM.NPLIVQQSGIKAPTRPSDYDE.................
A0A9P1AVY7_9PELO/350-406 .......PPILVDFVDRFTy.eSENNVT..HPRANQYDSKPPYGGIAFLEDPFFR.ERLIPKPKE------------cpw..............
G8JY28_CAEEL/268-331 .......PPSMEDCIRAHS...DPNLPP..HPRADQYPASFTRPMVEYCEDIYWT.HRTGQLPPGLQVPRRPYDYYH.................
Q20791_CAEEL/70-131 .......PPSIECCVRENQ...--GLPP..HPRANQYPAHFCKAMVAYCEDPYWT.ERTVPLPPGLVVPRRPLDYY-n................
E3MJK7_CAERE/297-362 .......PPLLLEIMEQFY..fYSEKKGqkHPIAQFYPPSYTYEMIEYCEDRYWT.EHQGELPGRLKYPQK------rvtwv............
A0A2G5SZE5_9PELO/293-359 .......PPVWYEFCQAAE..kMSAEAKamHPRANQYPSKFSYELIEFCEDPYWE.NHEGKIPDGLQIPQRPFDIE-d................
TRA2_CAEBR/1366-1429 .......PPSMEEYVQKYD...DPNQPP..SRRADQYPPSFTPAMVGYCEDVYWK.YNERNLPDNVPMPPRPRDWDQ.................
B6IG15_CAEBR/368-432 .......PPIMYEMVENEK..vSPHTGP..HPRADKYPPGFSYAMIEYCEDPYWM.HPLIVQSSGIKAPTRPSDHE-e................
A0A2G5V006_9PELO/1290-1353 .......PPSMEEYVQKYD...DPNQPS..SRRADQYPPSFTPAMVGYCEDVYWK.YNERNLPDNVPMPPRPRDWDQ.................
TRA2_CAEEL/1356-1419 .......PPSMEDCIRAHS...DPNLPP..HPRADQYPASFTRPMVEYCEDIYWT.HRTGQLPPGLQVPRRPYDYYH.................
A0A131MBZ9_CAEEL/395-454 .......PPIIEEVLELTR...-NCPEK..HPKAHLYPPAFSYAMIEYSEDRFWT.ERTVDVPPGVLVPNGPR----r................
G0N9M8_CAEBE/1306-1370 .......PPILEEFIQAHD...IPGLGP..HPRADQYAPGLPRSFIAYCEDPFWTnQRTVRLPPGIMIPPRPFDYA-e................
G0MBG9_CAEBE/338-404 .......PPIMDEIVERVC..lMPEESTiiHPKAYRWPVQYTYTMVEYAEDPFWT.ERTIPIPAGLLVPPDPIDGK-y................
E3MP33_CAERE/186-262 .......PPILQEILEKVS..kLPGGPAkkHPKAIFYPPSFSYQMVEYCEDPFWT.ERVVEIPEGYIRPH-------krieiangppppvdwtq
A0A9P1ADK1_9PELO/1421-1482 .......PPIMEELIVEHN...--GLGR..HPRADQYPDRFTRAMVAYSEDIYWT.ERIVPLPFGLDVPPRPYDYF-d................
E3MLM0_CAERE/95-158 .......PPSIEECIQAHS...DPILPP..HPRAGQYPRHYSRAMVAYCEDVYWT.YNIGRLPPGVQMPPRPRDWM-s................
E3LQQ1_CAERE/1379-1442 .......PPNLQECIQQND...DPSLPP..HPRRHQYPDHYGRAMISYCEDVYWT.YNDGRLPPNVAMPPRPFDWH-y................
A0A9P1AXK7_9PELO/329-392 .......PPIMEDFANRFYd.eVVTKTK..HQYQDQYPPTFNYAMVAYNEDPFWT.EREHH----------------asgaglprvlpkdf...
E3MLR4_CAERE/250-313 .......PPNIQECIQQND...DLTLPP..HPRRYQYPENYSRAMICYCEDVYWT.YNEGRLPSNVVMPPRPFDWN-i................
G0MB02_CAEBE/376-440 .......PPRLEEFIQAND...IPGLGP..HPRAAQYPPGLPRSFIAYCEDPFWTsQRTVRLPPGIMIPPRPFDYA-e................
A0A261CHW5_9PELO/93-156 .......PPSVEECIQAHS...DPILPP..HPRAGQYPRHYSRAMVAYCEDVYWT.YNSGRLPRGVHMPPRPRDW--is...............
A0A261CP56_9PELO/349-415 .......PPLLLEIMEQFYfysDKKGQK..HPIAEFYPPSYTYEMIEYCEDPYWT.KHQGELPGRLKYPQK------rvtwvd...........
A0A8R1HV24_CAEJA/407-469 .......PPNVDEFVELFY...-GITER..HPRADQYPASFSRAMIEYCEDPYWT.RRTVPLPRGVTVPPRPSDYYH.................
A0A261B266_9PELO/220-256 snssvhp------------...------..----------------SYCEDVYWV.YNDGRLPPNIEMPPRPFDWD-l................
A0A131MD22_CAEEL/360-419 .......PPIIEEVLELTR...-NCPEK..HPKAHLYPPAFSYAMIEYSEDRFWT.ERTVDVPPGVLVPNGPR----r................
A8WZJ9_CAEBR/293-332 .......PPVWYEFCQAAE..kMSAEAKtkHPRANQYPSKFSYELIEF-------.---------------------l................
A0A2G5UZY8_9PELO/332-395 .......PPSMEEYVQKYD...DPNQPS..SRRADQYPPSFTPAMVGYCEDVYWK.YNERNLPDNVPMPPRPRDWDQ.................
A0A261C047_9PELO/188-263 .......PPILQEILEKIS..kLPGGPSkkHPKAIFYPSYFSYQMVEYCEDPFWT.ERVVEIPEGYIRPH-------krlefangppppvdwt.
#=GC seq_cons .......PP.hcEhlpthp....sshss..HPRAsQYPssaohuMltYCEDsYWT.pppspLPssl.hPsRPhDa...................
//
