GenomeNet

Database: Pfam
Entry: TSR
LinkDB: TSR
Original site: TSR 
#=GF ID   TSR
#=GF AC   PF18487.4
#=GF DE   Thrombospondin type 1 repeat
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF01584
#=GF GA   25.00 25.00;
#=GF TC   26.80 40.10;
#=GF NC   24.40 23.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Repeat
#=GF RN   [1]
#=GF RM   28366782
#=GF RT   Identification and characterization of properdin in amphioxus:
#=GF RT   Implications for a functional alternative complement pathway in
#=GF RT   the basal chordate.
#=GF RA   Gao Z, Ma Z, Qu B, Jiao D, Zhang S;
#=GF RL   Fish Shellfish Immunol. 2017;65:1-8.
#=GF RN   [2]
#=GF RM   28069958
#=GF RT   Properdin binding to complement activating surfaces depends on
#=GF RT   initial C3b deposition.
#=GF RA   Harboe M, Johnson C, Nymo S, Ekholt K, Schjalm C, Lindstad JK,
#=GF RA   Pharo A, Hellerud BC, Nilsson Ekdahl K, Mollnes TE, Nilsson PH;
#=GF RL   Proc Natl Acad Sci U S A. 2017;114:E534.
#=GF RN   [3]
#=GF RM   15491616
#=GF RT   The dimeric and trimeric solution structures of the multidomain
#=GF RT   complement protein properdin by X-ray scattering, analytical
#=GF RT   ultracentrifugation and constrained modelling.
#=GF RA   Sun Z, Reid KB, Perkins SJ;
#=GF RL   J Mol Biol. 2004;343:1327-1343.
#=GF DR   SO; 0001068; polypeptide_repeat;
#=GF CC   This is a thrombospondin type I repeat (TSR) found in properdin.
#=GF CC   Properdin, also known as factor P (fP), is a glycoprotein
#=GF CC   constructed from a common pool of structure units or modules,
#=GF CC   which are homologous to the thrombospondin type 1 repeat, TSR.
#=GF CC   It is positive regulator of the complement system that
#=GF CC   stabilises the alternative pathway C3-convertase C3bBb.
#=GF CC   Properdin also inhibits the factor H-mediated cleavage of C3b by
#=GF CC   factor I. In addition, properdin acts as a pattern recognition
#=GF CC   molecule capable of identifying and interacting with microbial
#=GF CC   surfaces, apoptotic cells, and necrotic cells [1]. However this
#=GF CC   role of pattern recognition is controversial [2]. Studies
#=GF CC   indicate that this domain is a TSR variants. It is present at
#=GF CC   the N-terminal of properdin and has been denoted as TSR-0. It is
#=GF CC   suggested that the TSR-0 domain of properdin which possesses
#=GF CC   only the six Cys residues and no CWR-layered motif (which is
#=GF CC   usually found in other TSR domains) may constitute a truncated
#=GF CC   TSR domain [3].
#=GF SQ   241
#=GS A0A0D9RMD2_CHLSB/28-77    AC A0A0D9RMD2.1
#=GS A0A5C6NTY8_9TELE/20-65    AC A0A5C6NTY8.1
#=GS G3HXI8_CRIGR/24-73        AC G3HXI8.1
#=GS G5B0C5_HETGA/25-74        AC G5B0C5.1
#=GS A0A498MTP6_LABRO/1-47     AC A0A498MTP6.1
#=GS B0BNN4_RAT/24-73          AC B0BNN4.1
#=GS A0A672QGF6_SINGR/22-69    AC A0A672QGF6.1
#=GS A0A2K5ZMG5_MANLE/28-77    AC A0A2K5ZMG5.1
#=GS A0A060WWN2_ONCMY/21-68    AC A0A060WWN2.1
#=GS A0A674MPC0_TAKRU/11-56    AC A0A674MPC0.1
#=GS A0A671DUR6_RHIFE/27-76    AC A0A671DUR6.1
#=GS G1M2K7_AILME/63-112       AC G1M2K7.2
#=GS A0A485PN00_LYNPA/29-78    AC A0A485PN00.1
#=GS A0A4D9DIX2_9SAUR/46-93    AC A0A4D9DIX2.1
#=GS A0A1S3MDI6_SALSA/21-68    AC A0A1S3MDI6.1
#=GS A0A674BBP6_SALTR/21-68    AC A0A674BBP6.1
#=GS A0A671W2V4_SPAAU/13-60    AC A0A671W2V4.1
#=GS A0A3B5PNR6_XIPMA/67-114   AC A0A3B5PNR6.1
#=GS A0A1S3GQN7_DIPOR/24-73    AC A0A1S3GQN7.1
#=GS A0A669EAJ2_ORENI/26-73    AC A0A669EAJ2.1
#=GS A0A6P5BL90_BOSIN/27-76    AC A0A6P5BL90.1
#=GS A0A7R5L7K5_9PASS/21-73    AC A0A7R5L7K5.1
#=GS G1QT70_NOMLE/28-77        AC G1QT70.1
#=GS A0A671LL47_9TELE/21-68    AC A0A671LL47.1
#=GS A0A340WTL1_LIPVE/28-77    AC A0A340WTL1.1
#=GS A0A6J0YWZ8_ODOVR/25-74    AC A0A6J0YWZ8.1
#=GS A0A452FG11_CAPHI/24-73    AC A0A452FG11.1
#=GS A0A670YLL8_PSETE/25-74    AC A0A670YLL8.1
#=GS E2RH18_CANLF/24-73        AC E2RH18.1
#=GS A0A673VLD1_SURSU/35-84    AC A0A673VLD1.1
#=GS E9PAQ1_HUMAN/28-77        AC E9PAQ1.1
#=GS H3A977_LATCH/26-75        AC H3A977.1
#=GS Q17QC8_BOVIN/27-76        AC Q17QC8.1
#=GS A0A671W4B4_SPAAU/24-71    AC A0A671W4B4.1
#=GS A0A2K5IPF9_COLAP/29-78    AC A0A2K5IPF9.1
#=GS A0A2K6L925_RHIBE/28-77    AC A0A2K6L925.1
#=GS A0A2K5QKY6_CEBIM/28-77    AC A0A2K5QKY6.1
#=GS A0A6J0U262_9SAUR/27-76    AC A0A6J0U262.1
#=GS A0A6P6PWY7_CARAU/21-68    AC A0A6P6PWY7.1
#=GS A0A4W5NG09_9TELE/21-66    AC A0A4W5NG09.1
#=GS A0A498N5K1_LABRO/1-47     AC A0A498N5K1.1
#=GS A0A665WW25_ECHNA/18-65    AC A0A665WW25.1
#=GS A0A3P9Q3T3_POERE/22-69    AC A0A3P9Q3T3.1
#=GS A0A672QGB5_SINGR/27-74    AC A0A672QGB5.1
#=GS A0A672V6G2_STRHB/25-77    AC A0A672V6G2.1
#=GS H0V9N6_CAVPO/27-76        AC H0V9N6.1
#=GS A0A6P7XCC9_9AMPH/21-70    AC A0A6P7XCC9.1
#=GS A0A3Q1M2R9_BOVIN/136-185  AC A0A3Q1M2R9.1
#=GS F7CIH0_MONDO/57-106       AC F7CIH0.2
#=GS A0A6J1YX71_ACIJB/29-78    AC A0A6J1YX71.1
#=GS A0A3Q3GVJ8_9LABR/24-71    AC A0A3Q3GVJ8.1
#=GS A0A6Q2WW55_ESOLU/22-69    AC A0A6Q2WW55.1
#=GS A0A6G0HTY5_LARCR/23-70    AC A0A6G0HTY5.1
#=GS A0A6P6N9D3_CARAU/21-68    AC A0A6P6N9D3.1
#=GS A0A3Q1IRU7_ANATE/18-65    AC A0A3Q1IRU7.1
#=GS A9C4A2_DANRE/21-68        AC A9C4A2.1
#=GS A0A484CIH4_PERFV/19-66    AC A0A484CIH4.1
#=GS A0A1L8F5L1_XENLA/25-74    AC A0A1L8F5L1.1
#=GS A0A6G1QDY4_9TELE/18-65    AC A0A6G1QDY4.1
#=GS A0A674PGR6_TAKRU/18-63    AC A0A674PGR6.1
#=GS H2LMQ3_ORYLA/21-68        AC H2LMQ3.1
#=GS A0A6I9YNZ8_9SAUR/29-78    AC A0A6I9YNZ8.1
#=GS M3W950_FELCA/29-78        AC M3W950.3
#=GS A0A2K6B0D4_MACNE/28-77    AC A0A2K6B0D4.1
#=GS M3YPN8_MUSPF/24-73        AC M3YPN8.1
#=GS A0A671MYT4_9TELE/22-69    AC A0A671MYT4.1
#=GS A0A6P8F2Q9_CLUHA/30-77    AC A0A6P8F2Q9.1
#=GS A0A672QGD3_SINGR/21-68    AC A0A672QGD3.1
#=GS A0A6P9DCF9_PANGU/29-78    AC A0A6P9DCF9.1
#=GS I3MEI1_ICTTR/24-73        AC I3MEI1.2
#=GS A0A2K6GRN8_PROCO/27-75    AC A0A2K6GRN8.1
#=GS A0A671W494_SPAAU/209-256  AC A0A671W494.1
#=GS S9WBV0_CAMFR/29-78        AC S9WBV0.1
#=GS F6SP74_HORSE/27-76        AC F6SP74.1
#=GS A0A662YP07_ACIRT/1-43     AC A0A662YP07.1
#=GS A0A5G2RA87_PIG/26-75      AC A0A5G2RA87.1
#=GS A0A2K5V0Z6_MACFA/29-78    AC A0A2K5V0Z6.2
#=GS A0A674BBS8_SALTR/29-76    AC A0A674BBS8.1
#=GS A0A3Q7PD64_CALUR/23-72    AC A0A3Q7PD64.1
#=GS A0A6I9JP05_CHRAS/25-74    AC A0A6I9JP05.1
#=GS A0A671W3M3_SPAAU/13-60    AC A0A671W3M3.1
#=GS A0A1U7R4J5_MESAU/24-73    AC A0A1U7R4J5.1
#=GS A0A667X5C2_9TELE/63-111   AC A0A667X5C2.1
#=GS A0A3Q3WMH8_MOLML/9-56     AC A0A3Q3WMH8.1
#=GS A0A6J3G8S1_SAPAP/28-77    AC A0A6J3G8S1.1
#=GS A0A3Q1C553_AMPOC/34-81    AC A0A3Q1C553.1
#=GS A0A3Q2VRV3_HAPBU/21-68    AC A0A3Q2VRV3.1
#=GS PROP_MOUSE/24-73          AC P11680.2
#=GS A0A0P7U409_SCLFO/6-53     AC A0A0P7U409.1
#=GS A0A096MNK5_PAPAN/28-77    AC A0A096MNK5.1
#=GS A0A671W3L9_SPAAU/209-256  AC A0A671W3L9.1
#=GS A0A5F8HIC4_MONDO/18-67    AC A0A5F8HIC4.1
#=GS A0A2Y9DLP9_TRIMA/24-73    AC A0A2Y9DLP9.1
#=GS A0A5E4CM08_MARMO/24-73    AC A0A5E4CM08.1
#=GS A0A6I9MC76_PERMB/24-73    AC A0A6I9MC76.1
#=GS A0A2K5P164_CERAT/28-77    AC A0A2K5P164.1
#=GS L8IE64_9CETA/30-79        AC L8IE64.1
#=GS A0A673FLM6_9TELE/1-47     AC A0A673FLM6.1
#=GS A0A2I4CBY1_9TELE/21-68    AC A0A2I4CBY1.1
#=GS A0A7N9DB40_MACFA/28-77    AC A0A7N9DB40.1
#=GS A0A060XDG4_ONCMY/21-66    AC A0A060XDG4.1
#=GS W5KJX1_ASTMX/22-68        AC W5KJX1.2
#=GS G1KKP3_ANOCA/29-78        AC G1KKP3.2
#=GS A0A151MYJ4_ALLMI/4-51     AC A0A151MYJ4.1
#=GS A0A671W3L9_SPAAU/110-157  AC A0A671W3L9.1
#=GS B0S697_DANRE/21-68        AC B0S697.1
#=GS A0A6J2MGS8_9CHIR/30-79    AC A0A6J2MGS8.1
#=GS A0A3Q3GL68_9LABR/48-95    AC A0A3Q3GL68.1
#=GS A0A673ZX08_SALTR/21-66    AC A0A673ZX08.1
#=GS A0A6P7N9E0_BETSP/18-65    AC A0A6P7N9E0.1
#=GS A0A6P8P8L1_GEOSA/21-70    AC A0A6P8P8L1.1
#=GS A0A668T1Z1_OREAU/21-68    AC A0A668T1Z1.1
#=GS A0A674MBG1_TAKRU/56-101   AC A0A674MBG1.1
#=GS A0A4W4FL99_ELEEL/18-65    AC A0A4W4FL99.1
#=GS W5NAH4_LEPOC/19-67        AC W5NAH4.1
#=GS A0A6P3H6J1_BISBI/27-76    AC A0A6P3H6J1.1
#=GS A0A669DU42_ORENI/21-68    AC A0A669DU42.1
#=GS A0A2K5E4U9_AOTNA/28-77    AC A0A2K5E4U9.1
#=GS A0A6J1V9G4_9SAUR/29-78    AC A0A6J1V9G4.1
#=GS A0A1S3AMP7_ERIEU/23-72    AC A0A1S3AMP7.1
#=GS H3CC18_TETNG/22-67        AC H3CC18.1
#=GS A0A2K6U639_SAIBB/28-77    AC A0A2K6U639.1
#=GS A0A671W644_SPAAU/110-157  AC A0A671W644.1
#=GS A0A3Q7SA75_VULVU/24-73    AC A0A3Q7SA75.1
#=GS A0A1U8DV08_ALLSI/27-73    AC A0A1U8DV08.2
#=GS A0A6I8MYX4_ORNAN/35-86    AC A0A6I8MYX4.1
#=GS A0A6J0EFV0_PERMB/53-102   AC A0A6J0EFV0.1
#=GS S7N0W7_MYOBR/27-76        AC S7N0W7.1
#=GS PROP_PONAB/28-77          AC Q5RBP8.1
#=GS A0A3Q3BGI6_KRYMA/88-135   AC A0A3Q3BGI6.1
#=GS A0A670KHQ2_PODMU/27-76    AC A0A670KHQ2.1
#=GS A0A452S6D2_URSAM/33-76    AC A0A452S6D2.1
#=GS A0A671W656_SPAAU/110-157  AC A0A671W656.1
#=GS A0A087XX76_POEFO/22-69    AC A0A087XX76.1
#=GS A0A1S3LII4_SALSA/21-66    AC A0A1S3LII4.1
#=GS A0A3Q1C3E9_AMPOC/14-61    AC A0A3Q1C3E9.1
#=GS A0A212C0Y9_CEREH/25-74    AC A0A212C0Y9.1
#=GS A0A4U1EDW7_MONMO/28-77    AC A0A4U1EDW7.1
#=GS A0A6P7IXD7_9TELE/21-69    AC A0A6P7IXD7.1
#=GS A0A673MA36_9TELE/21-68    AC A0A673MA36.1
#=GS A0A3P8VEI0_CYNSE/18-65    AC A0A3P8VEI0.1
#=GS L5L193_PTEAL/27-76        AC L5L193.1
#=GS A0A2R9BZ89_PANPA/28-77    AC A0A2R9BZ89.1
#=GS A0A4W5LU67_9TELE/21-68    AC A0A4W5LU67.1
#=GS A0A4W2BZ28_BOBOX/27-76    AC A0A4W2BZ28.1
#=GS A0A671N066_9TELE/21-68    AC A0A671N066.1
#=GS A0A096LRQ3_POEFO/18-65    AC A0A096LRQ3.1
#=GS A0A6I9IJ95_VICPA/85-134   AC A0A6I9IJ95.1
#=GS A0A5F4WLJ9_CALJA/28-77    AC A0A5F4WLJ9.1
#=GS A0A4W6C4Q1_LATCA/24-71    AC A0A4W6C4Q1.1
#=GS A0A6F9BJG8_9TELE/21-66    AC A0A6F9BJG8.1
#=GS A0A5N3VXQ8_MUNRE/25-74    AC A0A5N3VXQ8.1
#=GS H2RMQ3_TAKRU/56-101       AC H2RMQ3.3
#=GS A0A672FNX1_SALFA/32-79    AC A0A672FNX1.1
#=GS A0A2U3VP49_ODORO/20-69    AC A0A2U3VP49.1
#=GS A0A672F1M8_SALFA/16-63    AC A0A672F1M8.1
#=GS A0A2K6R4Y4_RHIRO/28-77    AC A0A2K6R4Y4.1
#=GS H0X555_OTOGA/27-75        AC H0X555.1
#=GS A0A2J8IU45_PANTR/28-77    AC A0A2J8IU45.1
#=GS K7GQR1_PIG/59-108         AC K7GQR1.2
#=GS A0A6A1Q1Y1_BALPH/50-99    AC A0A6A1Q1Y1.1
#=GS A0A402FNU9_9SAUR/44-93    AC A0A402FNU9.1
#=GS A0A437CEF7_ORYJA/21-68    AC A0A437CEF7.1
#=GS A0A6P3RRG3_PTEVA/27-76    AC A0A6P3RRG3.1
#=GS A0A3P9B8L2_9CICH/21-68    AC A0A3P9B8L2.1
#=GS A0A4W2BZ21_BOBOX/27-76    AC A0A4W2BZ21.1
#=GS F7IDK9_CALJA/28-77        AC F7IDK9.1
#=GS A0A3Q7XR31_URSAR/24-73    AC A0A3Q7XR31.1
#=GS A0A3B5QCJ7_XIPMA/67-114   AC A0A3B5QCJ7.1
#=GS A0A5A9NZ94_9TELE/21-68    AC A0A5A9NZ94.1
#=GS A0A7R5L7L1_9PASS/21-73    AC A0A7R5L7L1.1
#=GS A0A671W3L5_SPAAU/110-157  AC A0A671W3L5.1
#=GS A0A4W3GNM8_CALMI/23-71    AC A0A4W3GNM8.1
#=GS A0A315W5G8_GAMAF/63-101   AC A0A315W5G8.1
#=GS A0A7R5L7K2_9PASS/21-73    AC A0A7R5L7K2.1
#=GS A0A671W675_SPAAU/105-152  AC A0A671W675.1
#=GS A0A452S6H3_URSAM/3-46     AC A0A452S6H3.1
#=GS A0A3Q1MHU8_BOVIN/14-63    AC A0A3Q1MHU8.1
#=GS A0A803K999_XENTR/23-72    AC A0A803K999.1
#=GS A0A673VL87_SURSU/133-182  AC A0A673VL87.1
#=GS A0A3P8SIX7_AMPPE/21-68    AC A0A3P8SIX7.1
#=GS A0A6P6PJ83_CARAU/21-68    AC A0A6P6PJ83.1
#=GS F6ZPU1_ORNAN/14-65        AC F6ZPU1.3
#=GS G1U9S1_RABIT/26-75        AC G1U9S1.2
#=GS A0A4W5LVW5_9TELE/24-71    AC A0A4W5LVW5.1
#=GS A0A3P8YDK5_ESOLU/20-67    AC A0A3P8YDK5.1
#=GS F1RWV1_PIG/23-72          AC F1RWV1.4
#=GS G1Q8L3_MYOLU/34-83        AC G1Q8L3.1
#=GS A0A3Q3WMH5_MOLML/11-58    AC A0A3Q3WMH5.1
#=GS A0A3P9B8A5_9CICH/21-68    AC A0A3P9B8A5.1
#=GS A0A4X2KZC2_VOMUR/32-81    AC A0A4X2KZC2.1
#=GS L8Y675_TUPCH/33-81        AC L8Y675.1
#=GS A0A452FGS4_CAPHI/62-111   AC A0A452FGS4.1
#=GS A0A6J3QUY0_TURTR/28-77    AC A0A6J3QUY0.1
#=GS A0A7R5L7L5_9PASS/21-73    AC A0A7R5L7L5.1
#=GS G3R040_GORGO/28-77        AC G3R040.1
#=GS A0A3Q1FH83_9TELE/21-68    AC A0A3Q1FH83.1
#=GS A0A674BBR7_SALTR/24-71    AC A0A674BBR7.1
#=GS G3STF5_LOXAF/23-72        AC G3STF5.1
#=GS A0A455B260_PHYMC/27-76    AC A0A455B260.1
#=GS A0A6P3VLR8_CLUHA/25-72    AC A0A6P3VLR8.1
#=GS A0A1A6H3G5_NEOLE/46-95    AC A0A1A6H3G5.1
#=GS A0A2Y9JS01_ENHLU/22-71    AC A0A2Y9JS01.1
#=GS A0A673VKY4_SURSU/133-182  AC A0A673VKY4.1
#=GS A0A3Q4BHH2_MOLML/25-72    AC A0A3Q4BHH2.1
#=GS A0A2U3XL84_LEPWE/23-72    AC A0A2U3XL84.2
#=GS A0A6G1BFR2_CROCR/30-79    AC A0A6G1BFR2.1
#=GS A0A673FQJ2_9TELE/21-68    AC A0A673FQJ2.1
#=GS W5PTL2_SHEEP/26-75        AC W5PTL2.1
#=GS A0A4W5LV63_9TELE/14-61    AC A0A4W5LV63.1
#=GS G3PPI0_GASAC/21-68        AC G3PPI0.1
#=GS A0A383ZYY3_BALAS/28-77    AC A0A383ZYY3.2
#=GS A0A6P6N9D3_CARAU/474-521  AC A0A6P6N9D3.1
#=GS A0A341BUM4_NEOAA/28-77    AC A0A341BUM4.1
#=GS A0A384CEV5_URSMA/1-46     AC A0A384CEV5.1
#=GS A0A6F9B164_9TELE/6-55     AC A0A6F9B164.1
#=GS PROP_CAVPO/27-76          AC Q64181.1
#=GS A0A3Q3X1N4_MOLML/25-72    AC A0A3Q3X1N4.1
#=GS L5LE69_MYODS/27-76        AC L5LE69.1
#=GS A0A672KTE7_SINGR/21-68    AC A0A672KTE7.1
#=GS A0A672QG82_SINGR/21-68    AC A0A672QG82.1
#=GS A0A671W494_SPAAU/110-157  AC A0A671W494.1
#=GS F7CGG5_MACMU/28-77        AC F7CGG5.2
#=GS A0A6J2W6Z7_CHACN/20-67    AC A0A6J2W6Z7.1
#=GS A0A672F1L8_SALFA/24-71    AC A0A672F1L8.1
#=GS A0A2Y9LYJ7_DELLE/28-77    AC A0A2Y9LYJ7.1
#=GS A0A6A5EMZ0_PERFL/21-68    AC A0A6A5EMZ0.1
#=GS PROP_HUMAN/28-77          AC P27918.2
#=GS PROP_HUMAN/28-77          DR PDB; 6RV6 A; 28-77;
#=GS PROP_HUMAN/28-77          DR PDB; 6SEJ A; 28-77;
#=GS PROP_HUMAN/28-77          DR PDB; 6RUV X; 28-77;
#=GS PROP_HUMAN/28-77          DR PDB; 6S0B B; 28-77;
#=GS PROP_HUMAN/28-77          DR PDB; 6RUR X; 28-77;
#=GS PROP_HUMAN/28-77          DR PDB; 6RUV U; 28-77;
#=GS PROP_HUMAN/28-77          DR PDB; 6RUR U; 28-77;
#=GS PROP_HUMAN/28-77          DR PDB; 6RUS A; 28-77;
#=GS PROP_HUMAN/28-77          DR PDB; 6S08 B; 28-77;
#=GS PROP_HUMAN/28-77          DR PDB; 6S0A B; 28-77;
#=GS A0A6P3FBC1_OCTDE/27-76    AC A0A6P3FBC1.1
#=GS A0A5N4C0V7_CAMDR/32-81    AC A0A5N4C0V7.1
#=GS A0A1L8F5K8_XENLA/22-71    AC A0A1L8F5K8.1
#=GS A0A091CXT7_FUKDA/27-76    AC A0A091CXT7.1
#=GS A0A3Q2G1M6_CYPVA/22-69    AC A0A3Q2G1M6.1
#=GS A0A671W644_SPAAU/209-256  AC A0A671W644.1
#=GS A0A1U7UMN2_CARSF/27-76    AC A0A1U7UMN2.1
#=GS A0A674MS28_TAKRU/22-67    AC A0A674MS28.1
#=GS M3ZNP1_XIPMA/67-114       AC M3ZNP1.2
#=GS A0A4W5LV25_9TELE/21-68    AC A0A4W5LV25.1
#=GS A0A5N5NLK8_PANHP/23-70    AC A0A5N5NLK8.1
#=GS A0A6P6IN05_PUMCO/29-78    AC A0A6P6IN05.1
#=GS A0A670YVS5_PSETE/25-74    AC A0A670YVS5.1
A0A0D9RMD2_CHLSB/28-77               ...DPVLCFTQYEEPS..GKCKGL..LGGG.V.SVKDCCLNTAYAYQERN..GGLCQPCRS.
A0A5C6NTY8_9TELE/20-65               ..a-GVRCFSQFNQ--..GQCVGE..LG-E.V.EEDDCCQNPRYGHKDTD..GQ-CRSCGP.
G3HXI8_CRIGR/24-73                   ...DPVFCFTKYEESS..GKCKGL..LGGD.V.SVEDCCLNAAYAFQEHG..GGPCQACR-r
G5B0C5_HETGA/25-74                   ...DPVLCFTHYEDST..GRCKGL..LGRD.I.SVENCCLNAAYAFQERD..GGLCQACRS.
A0A498MTP6_LABRO/1-47                ...-MVECFSLFDLSS..GECGKL..LG-Q.V.GKQDCCMNPNYGYKEPD..GI-CRSCG-l
B0BNN4_RAT/24-73                     ...DPVLCFTQYEEPS..GRCKGL..LGRD.I.RVEDCCLNTAYAFQEHD..GGLCQSCRS.
A0A672QGF6_SINGR/22-69               ...EMVECFSSFTLST..GKCGDL..LG-Q.V.EKNSCCLNPSYAYKEAD..GV-CRFCG-r
A0A2K5ZMG5_MANLE/28-77               ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVKDCCLNTAYAYQERN..GGLCQPCRS.
A0A060WWN2_ONCMY/21-68               ...QEVNCYSSFDS--..GNCDDLwlLG-E.V.TMDDCCLNPHYGYIGAD..RK-CKSCGP.
A0A674MPC0_TAKRU/11-56               .tg--ARCFSQFNQ--..GQCVGE..LG-E.V.EEDDCCQNPHYGHKDTD..GQ-CRSCGP.
A0A671DUR6_RHIFE/27-76               ...DPVLCFTQYEESS..GKCKGL..LGGG.V.RVEDCCLNSAYAFQEPD..SKLCQACRS.
G1M2K7_AILME/63-112                  ..v-PVLCFTQYEESS..GKCKGL..LGGG.V.SVEDCCLNPAYGFQKPG..SKLCHACRS.
A0A485PN00_LYNPA/29-78               ...DPVLCFTQYEEAT..GKCTGL..LGGG.V.SVNDCCLNPAYAFQKPG..SKLCQACRP.
A0A4D9DIX2_9SAUR/46-93               ..q-EGLCYEQFAA--..GKCKEF..LGED.V.PEADCCLNPNYGYRPRA..GAPCQSCG-q
A0A1S3MDI6_SALSA/21-68               ...QEVNCYSSFDS--..GNCDDLwlLG-E.V.TMDDCCLNPHYGYIGAD..GK-CKSCGP.
A0A674BBP6_SALTR/21-68               ...QEVNCYSSFDS--..GNCDDLwlLG-E.V.TMDDCCLNPHYGYIGAD..GK-CKSCGP.
A0A671W2V4_SPAAU/13-60               ...ECVRCFVRFNPTL..GQCDEE..LG-E.V.DEDDCCQNPQYGYQAAD..GV-CHSCGP.
A0A3B5PNR6_XIPMA/67-114              ...ECVRCFGSFDLTT..GECSED..LG-D.V.DEDDCCQNSQYGYEAED..GS-CHSCGP.
A0A1S3GQN7_DIPOR/24-73               ...DPVICFTQYEEST..GKCQGL..LGGG.V.RAEDCCLNTAYAFQEHS..SGLCQACRS.
A0A669EAJ2_ORENI/26-73               ...DCVRCFARFDLNT..GECNEE..IG-E.V.DEDDCCQNPNYGYMETD..GQ-CESCG-l
A0A6P5BL90_BOSIN/27-76               ...DPVFCFAQYEEST..GKCKDL..LGRG.V.SVEDCCLNAGYAFQKPG..SNLCMACR-l
A0A7R5L7K5_9PASS/21-73               ..t-PVWCFARLEEAEggGACVEL..LSDEpV.PLADCCLNPAYGYRLRP..HGRCLSCRQ.
G1QT70_NOMLE/28-77                   ...DPVHCFTQYEESS..GKCKGL..LGGG.V.SVKDCCLNTASAYQERS..GGLCQPCRS.
A0A671LL47_9TELE/21-68               ...QMVDCFSSFTLST..GKCSGL..LG-Q.V.KKDDCCLNTNYGYKEAD..GV-CRSCG-w
A0A340WTL1_LIPVE/28-77               ...DSVLCFTQYEEST..GKCKGL..LGGG.V.STEDCCLNADYAFQEPG..SKLCMACR-l
A0A6J0YWZ8_ODOVR/25-74               ...DSVQCFAQYEEST..GKCKDF..LGGG.V.SVEDCCLNAAYAFQKPG..SKLCMACR-l
A0A452FG11_CAPHI/24-73               ...DSVLCFAQYEEST..GKCKDL..LGGG.V.SMKNCCLNANYAFQKPG..SKLCMACR-l
A0A670YLL8_PSETE/25-74               ..v-NVLCYKTFDEIS..GTCSNL..LGDG.V.SQEDCCLNDQYGFQLTE..NGACQSCR-g
E2RH18_CANLF/24-73                   ..v-PIWCFTQYEESS..GKCQGF..LGKG.I.RVEDCCLNPAYAFQEPG..SKLCQACRS.
A0A673VLD1_SURSU/35-84               ...DPVFCFTQYEEAS..GKCTGL..LGGG.V.SVKDCCLNPTFAFQKPG..SNLCQACR-l
E9PAQ1_HUMAN/28-77                   ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVEDCCLNTAFAYQKRS..GGLCQPCRS.
H3A977_LATCH/26-75                   ..e-GVLCYITFDEVT..GTCTNL..LADN.V.DQKTCCLNTEYCFKKDK..ENKFQACRP.
Q17QC8_BOVIN/27-76                   ...DPVFCFAQYEEST..GKCKDL..LGRG.V.SVEDCCLNAGYAFQKPG..SNLCMACR-l
A0A671W4B4_SPAAU/24-71               ...ECVRCFAQFNQTL..GQCDEE..LG-E.V.DEDDCCQNPQYGYQAAD..GV-CHSCGP.
A0A2K5IPF9_COLAP/29-78               ...DPVLCFTQYEESS..SKCKGL..LGGG.V.SVKDCCLNTAYAYQERN..GGLCQPCRS.
A0A2K6L925_RHIBE/28-77               ...DPVLCFTQYEESS..SKCKGF..LGGG.V.SVKDCCLNTAYAYQERN..GGLCQPCRS.
A0A2K5QKY6_CEBIM/28-77               ...DPVFCFSQYEESS..GKCKGL..LGGG.V.SLKDCCLNAAYAYQERG..GGLCQPCRS.
A0A6J0U262_9SAUR/27-76               ...EDVLCYEKFDDTT..GTCSDL..LGGG.V.RLEDCCLNRQYGFRQAV..GGQCRACR-a
A0A6P6PWY7_CARAU/21-68               qla---DCFASFTLST..GKCSDL..LG-Q.V.KKDECCLNPSYGYKEAD..GV-CRSCG-r
A0A4W5NG09_9TELE/21-66               ..r-EVKCYSRFDN--..GDCGDL..LG-E.V.TIEDCCLNPHYGYIGAD..GK-CKFCGP.
A0A498N5K1_LABRO/1-47                ...-MVECFSLFDLSS..GECGKL..LG-Q.V.GKQDCCMNPNYGYKEPD..GI-CRSCG-l
A0A665WW25_ECHNA/18-65               ...ECVRCFARFDITS..GEGDEE..LG-E.V.DEDTCCQNTEYSFLKTD..GL-FQSCG-h
A0A3P9Q3T3_POERE/22-69               ...ECVRCFGSFDLTT..GECSED..LG-V.V.NQDDCCQNSQYGYEAED..GS-CRSCGP.
A0A672QGB5_SINGR/27-74               ...EMVECFSSFTLST..GKCGDL..LG-Q.V.EKNSCCLNPSYAYKEAD..GV-CRFCG-r
A0A672V6G2_STRHB/25-77               ..t-PVWCFSRLEEHAggGACAEL..LSEEpV.PLADCCLNPAYGYKLRP..QGHCHTCRS.
H0V9N6_CAVPO/27-76                   ...DPVLCFSQYEDSS..GKCKGL..LGKD.V.SLEDCCLNAAYAFKERD..NGHCQACRS.
A0A6P7XCC9_9AMPH/21-70               ..e-GVSCYGNFDDST..GKCLDF..ISDD.V.TQEDCCLNLKYGFKRSA..DGSCEACY-p
A0A3Q1M2R9_BOVIN/136-185             ...DPVFCFAQYEEST..GKCKDL..LGRG.V.SVEDCCLNAGYAFQKPG..SNLCMACR-l
F7CIH0_MONDO/57-106                  ...EAVRCFSNFEEAS..NQCMGF..LGEG.I.SKHACCLNAAYSFQIPG..SQTCQACG-a
A0A6J1YX71_ACIJB/29-78               ...DPVLCFTQYEEAT..GKCMGL..LGGG.V.SVNDCCLNPAYAFQKPG..SKLCQACRP.
A0A3Q3GVJ8_9LABR/24-71               ...ECVRCFARFDLIL..GQCDED..IG-E.V.DGDDCCQNPHYGYQATD..GV-CRSCGP.
A0A6Q2WW55_ESOLU/22-69               ...QEVKCYSKFDKNL..GNCANL..LG-N.V.GMDDCCLNTHYGYTGDD..GK-CKSCGP.
A0A6G0HTY5_LARCR/23-70               ...ECVRCFARFNLTL..GQCDEE..IG-E.V.DEDDCFQNPHYGYKAAD..GV-CRSCGP.
A0A6P6N9D3_CARAU/21-68               ...QKVDCFSSFTLSS..GKCGNL..LG-E.V.GKEDCCLNPSYGFKEAD..GV-CRSCG-r
A0A3Q1IRU7_ANATE/18-65               ...ECVRCFARFDLNS..GRCNEE..LG-E.V.DEDDCCQNPHYGYETTD..GA-CQSCGP.
A9C4A2_DANRE/21-68                   ...QMVQCFSAFSIST..GKCADL..LG-E.T.EKDFCCINPSYGFAEAD..GV-CRSCGH.
A0A484CIH4_PERFV/19-66               ...ECVRCFARFDLNL..GQCDEE..LG-E.M.DDDDCCQNPQYGYQGPD..GV-CRGCGP.
A0A1L8F5L1_XENLA/25-74               ..e-GVVCYSDFDERS..GGCTQY..LGEG.V.SEGDCCLNIKYSFKRDP..GAPCESCR-a
A0A6G1QDY4_9TELE/18-65               ...ECVRCFARFDLTS..GQCDEE..LG-N.V.DEDDCCQNPHYGYKTAD..GA-CQSCGP.
A0A674PGR6_TAKRU/18-63               .ag--ARCFSQFNQ--..GQCVGE..LG-E.V.EEDDCCQNPHYGHKDTD..GQ-CRSCGS.
H2LMQ3_ORYLA/21-68                   ...ECVRCFAAFNTTT..GECSDE..LG-E.V.DMDDCCHNPQYGYLTEE..GE-CQFCG-l
A0A6I9YNZ8_9SAUR/29-78               ...ENVLCYKTFDEIS..GTCNNL..LGDE.V.AQEDCCLNHEYGFQSTE..QGPCQSCR-e
M3W950_FELCA/29-78                   ...DPVLCFTQYEEAT..GKCTGL..LGGG.V.SVNDCCLNPAYAFQKPG..SKLCQACRP.
A0A2K6B0D4_MACNE/28-77               ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVKDCCLNTAYAYQEHN..GGLCQPCRS.
M3YPN8_MUSPF/24-73                   ..a-TVFCYTEYEESS..GMCKGL..LGGG.V.SVKDCCLNPAYGFQEPG..SKLCQACR-l
A0A671MYT4_9TELE/22-69               ...EMVECFSSFTLST..GKCGDL..LG-Q.V.EKNSCCLNPSYGYKEAD..GV-CRFCG-r
A0A6P8F2Q9_CLUHA/30-77               ..q-LVPCYSKFDMNT..GTCNEL..IG-N.V.TQGHCCFNSNYGFRKES..GK-CMSCRQ.
A0A672QGD3_SINGR/21-68               ...EMVECFSSFTLST..GKCGDL..LG-Q.V.EKNSCCLNPSYAYKEAD..GV-CRFCG-r
A0A6P9DCF9_PANGU/29-78               ..e-NILCYKTFDAVS..GTCSNL..LGGG.V.SQEDCCLNHEYGFQGTE..HGPCQSCR-e
I3MEI1_ICTTR/24-73                   ...DPVLCFSQYEEDS..GRCKGL..LGGG.V.SVEDCCLNAAYAFQESG..SGLCRACR-l
A0A2K6GRN8_PROCO/27-75               ...DPVLCFTQYEESS..GKCKGL..LG-S.V.KVEDCCLNAAFAFQEDG..SKICQICR-f
A0A671W494_SPAAU/209-256             ..g-CVRCFAQFNPTL..GQCDEE..LG-E.V.DEDDCCQNPQYGYQAAD..GV-CRSCGP.
S9WBV0_CAMFR/29-78                   ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVEDCCLNADYAFQESS..HSFCMACS-f
F6SP74_HORSE/27-76                   ...DPVLCFTQYEEST..GKCKDL..LGGG.V.SVEDCCLNPAYAFQEPG..KKLCQACR-f
A0A662YP07_ACIRT/1-43                ..m-------EFDYQT..GQCSRF..LSAE.V.EQSDCCLNPAYGFINEA..GK-CQSCGS.
A0A5G2RA87_PIG/26-75                 ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SLEDCCLNADYAFQETS..SKFCMPCRP.
A0A2K5V0Z6_MACFA/29-78               ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVKDCCLNTAYAYQERN..GGLCQPCRS.
A0A674BBS8_SALTR/29-76               ...QEVNCYSSFDS--..GNCDDLwlLG-E.V.TMDDCCLNPHYGYIGAD..GK-CKSCGP.
A0A3Q7PD64_CALUR/23-72               ..v-PVLCFTHYEESS..GICEGL..LGGG.V.SVEVCCLNPAYGFQEPG..SKLCQACR-l
A0A6I9JP05_CHRAS/25-74               ...DPVLCFTQYEESS..GKCKDL..LGGG.V.SADDCCLNSAYAFQEPG..SGICQICR-f
A0A671W3M3_SPAAU/13-60               ...ECVRCFVRFNPTL..GQCDEE..LG-E.V.DEDDCCQNPQYGYQAAD..GV-CHSCGP.
A0A1U7R4J5_MESAU/24-73               ...DPVLCFTQYEESS..GKCKGL..LEGD.V.SVEDCCLNAAYAFQEHG..GGPCQACRS.
A0A667X5C2_9TELE/63-111              ..k-CVRCFSRVDLRS..SLCVDE..LGEV.D.DEDDCCQNPHYGYQATD..GE-CHSCG-g
A0A3Q3WMH8_MOLML/9-56                ...ECVRCFARFDQVL..GECNDE..LG-D.V.DEDDCCQNPRYGYQDNN..DT-CKYCGS.
A0A6J3G8S1_SAPAP/28-77               ...DPVFCFSQYEESS..GKCKGL..LGGG.V.SLKDCCLNAAYAYQERS..GGLCHPCRS.
A0A3Q1C553_AMPOC/34-81               ...ECVRCFARFHLPS..GECDEE..LG-E.V.DKDDCCQNPNYGYQETD..GT-CQSCGP.
A0A3Q2VRV3_HAPBU/21-68               ...DCVRCFARFDLNT..GECNEE..IG-E.V.DEDDCCQNPNYGYMETD..GQ-CESCG-l
PROP_MOUSE/24-73                     ...DPVLCFTQYEESS..GRCKGL..LGRD.I.RVEDCCLNAAYAFQEHD..GGLCQACRS.
A0A0P7U409_SCLFO/6-53                ...EVVKCYGQFNKEK..GTCGLY..LG-E.T.ELDDCCLNVDYGFQIKD..GE-CDSCSP.
A0A096MNK5_PAPAN/28-77               ...DPVLCFTQYEESS..GKCKGL..LGSG.V.SVKDCCLNTAYAYQERN..GGLCQPCRS.
A0A671W3L9_SPAAU/209-256             ..g-CVRCFAQFNPTL..GQCDEE..LG-E.V.DEDDCCQNPQYGYQAAD..GV-CRSCGP.
A0A5F8HIC4_MONDO/18-67               ...EAVRCFSNFEEAS..NQCMGF..LGEG.I.SKHACCLNAAYSFQIPG..SQTCQACG-a
A0A2Y9DLP9_TRIMA/24-73               ...DPVLCFTQYEEST..GKCKDL..LGGG.V.SAEDCCLNTAYAFQEPG..SGLCQACRS.
A0A5E4CM08_MARMO/24-73               ...DPVLCFSQYEEDS..GKCKGL..LGGG.V.SVEDCCLNAAYAFQESG..SRLCRACR-l
A0A6I9MC76_PERMB/24-73               ...DPVFCFTQYEESS..GKCKGL..LGGD.I.SVEDCCLNAAYAFQEHA..GGLCQACRS.
A0A2K5P164_CERAT/28-77               ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVKDCCLNTAYAYQELN..GGLCQPCRS.
L8IE64_9CETA/30-79                   ...DPVFCFAQYEEST..GKCKDL..LGRG.V.SMEDCCLNAGYAFQKPG..SNLCMACR-l
A0A673FLM6_9TELE/1-47                ...-MVDCFSSFTLST..GKCSGL..LG-Q.V.KKDDCCLNSNYGYKEAD..GV-CRSCG-r
A0A2I4CBY1_9TELE/21-68               ...ECVQCFGVFDQDS..GVCSAE..IG-E.V.EEDDCCLNPNFGFKTED..GV-CHSCGS.
A0A7N9DB40_MACFA/28-77               ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVKDCCLNTAYAYQERN..GGLCQPCRS.
A0A060XDG4_ONCMY/21-66               ...QEVNCYSRFDN--..GDCGDL..LG-E.V.TIEDCCLNPHYGYIGAD..GK-CKFCGP.
W5KJX1_ASTMX/22-68                   ...QSVQCFTDFSLTD..GTCSDL..LG-D.L.PLEDCCMNPQYGFVERG..A--CKSCR-f
G1KKP3_ANOCA/29-78                   ...QDVHCYEAFDEAT..GSCHNL..LGTG.V.ATQDCCLNHAYGFQAGD..GAPCQSCRS.
A0A151MYJ4_ALLMI/4-51                ..q-IGRCYVDFAD--..GACRDL..LGEG.V.AEVDCCLNPHFGYRTQP..DAPCQACGP.
A0A671W3L9_SPAAU/110-157             ...ECVRCFVRFNPTL..GQCDEE..LG-E.V.DEDDCCQNPQYGYQAAD..GV-CHSCGP.
B0S697_DANRE/21-68                   ...QMVQCFSAFSIST..GKCADL..LG-E.I.EKDFCCINPSYGFAEAD..GV-CRSCGH.
A0A6J2MGS8_9CHIR/30-79               ...DPVVCFSQYEESS..GKCKDF..LGEG.V.REEDCCLNPNYAFQEPD..SKLCQACRP.
A0A3Q3GL68_9LABR/48-95               ...ECVRCFARFDLIL..GQCDED..IG-E.V.DGDDCCQNPHYGYQATD..GV-CRSCGP.
A0A673ZX08_SALTR/21-66               ...QEVKCYSRFDN--..GDCGDL..LG-E.V.TIEDCCLNPHYGYIGAD..RK-CKFCGP.
A0A6P7N9E0_BETSP/18-65               ...ECVRCFARFNPTL..GQCNEE..IG-D.V.VEDDCCQNPQYGYEAAD..GV-CQSCGP.
A0A6P8P8L1_GEOSA/21-70               ..e-GVSCYGTFDNST..GKCLDF..IGDD.V.TEEDCCLNIKYGFKRSA..NDPCEACY-p
A0A668T1Z1_OREAU/21-68               ...DCVRCFARFDLNT..GECNEE..IG-E.V.DEDDCCQNPNYGYMETD..GQ-CESCG-l
A0A674MBG1_TAKRU/56-101              .ag--ARCFSQFNQ--..GQCVGE..LG-E.V.EEDDCCQNPHYGHKDTD..GQ-CRSCGP.
A0A4W4FL99_ELEEL/18-65               ...QMVQCYSSFSLKD..GTCVDI..LG-Q.V.PLDDCCMNPKYSYQENG..KV-CKSCR-y
W5NAH4_LEPOC/19-67                   ..t-QVACYSTFSQET..GSCSGL..LGDG.V.DQDDCCLNPLYGFDRGD..GK-CRSCRP.
A0A6P3H6J1_BISBI/27-76               ...DPVFCFAQYEEST..GKCKDL..LGRG.V.SMEDCCLNAGYAFQKPG..SNLCMACR-l
A0A669DU42_ORENI/21-68               ...DCVRCFARFDLNT..GECNEE..IG-E.V.DEDDCCQNPNYGYMETD..GQ-CESCG-l
A0A2K5E4U9_AOTNA/28-77               ...DPVFCFSQYEESS..GKCKGL..LGGG.V.SLKDCCLNSAYAYQERS..GGLCQPCRS.
A0A6J1V9G4_9SAUR/29-78               ..a-NVLCYKTFDEIS..GTCSNL..LGDG.V.SQEDCCLNDQYGFQLTE..NGACQSCR-g
A0A1S3AMP7_ERIEU/23-72               ..n-PVLCFSQYEESS..GKCKGL..LGGG.V.SVEDCCLNTAYAFQVPG..SKLCQACRS.
H3CC18_TETNG/22-67                   ..v-GVRCFARFIQ--..GVCADE..LG-E.V.EEDDCCQNPHYGHQDTD..GQ-CRSCGS.
A0A2K6U639_SAIBB/28-77               ...DPVFCFSQYEESS..GKCKGL..LGGG.V.SLQDCCLNAAYAYQERS..SGLCQPCRS.
A0A671W644_SPAAU/110-157             ...ECVRCFVRFNPTL..GQCDEE..LG-E.V.DEDDCCQNPQYGYQAAD..GV-CHSCGP.
A0A3Q7SA75_VULVU/24-73               ..v-PIWCFTQYEESS..GKCQGF..LGKG.I.RVEDCCLNPAYAFQEPG..SKLCQACRS.
A0A1U8DV08_ALLSI/27-73               .qi--GWCYVDFAD--..GACRDL..LGEG.V.AEGDCCLHPHFXLPQPD..AP-CQACGP.
A0A6I8MYX4_ORNAN/35-86               ...ESVLCYSKFDEVM..GQCKEL..LGAG.V.SQEDCCMNPNYAFQPEGvpKGFCQSCRP.
A0A6J0EFV0_PERMB/53-102              ...DPVFCFTQYEESS..GKCKGL..LGGD.I.SVEDCCLNAAYAFQEHA..GGLCQACRS.
S7N0W7_MYOBR/27-76                   ...ESVLCFTQYEESS..GKCKGL..LGGG.V.RVQDCCLNAAYAFQEPG..SKLCQPCR-a
PROP_PONAB/28-77                     ...DPVLCFTRYEESS..GKCKGL..LGGG.V.SVKDCCLNTASAYQERS..GGLCQPCRS.
A0A3Q3BGI6_KRYMA/88-135              ...ECVRCFGVFNLNS..GECEAE..IG-E.V.DQDDCCQNPNYGYETED..GT-CQSCG-l
A0A670KHQ2_PODMU/27-76               ...QNVFCYGAFDVTS..GKCNDL..LGEG.V.AQDDCCLNHQYSFQLDR..NGPCQACQ-a
A0A452S6D2_URSAM/33-76               .mf--------YEESS..GKCKGL..LGGG.V.SVEDCCLNPAYGFQEPG..SKLCHACRS.
A0A671W656_SPAAU/110-157             ...ECVRCFVRFNPTL..GQCDEE..LG-E.V.DEDDCCQNPQYGYQAAD..GV-CHSCGP.
A0A087XX76_POEFO/22-69               ...ECVRCFGSFDLTT..GECSED..LG-D.V.NEDDCCQNSQYGYEAED..GS-CRSCGP.
A0A1S3LII4_SALSA/21-66               ...QEVKCYSRFDN--..GDCGDL..LG-E.V.TIEDCCLNPHYGYIGAD..RK-CKFCGP.
A0A3Q1C3E9_AMPOC/14-61               ..f-CVRCFARFHLPS..GECDEE..LG-E.V.DKDDCCQNPNYGYQETD..GT-CQSCGP.
A0A212C0Y9_CEREH/25-74               ...DSVQCFAQYEEST..GKCKDF..LGGG.V.RVEDCCLNAAYAFQKPG..SKLCMACRS.
A0A4U1EDW7_MONMO/28-77               ...DPVLCFTQYEEST..GKCKGL..LGGG.V.STEDCCLNADYAFQEPG..SKLCMACR-l
A0A6P7IXD7_9TELE/21-69               ...ECVRCFAEFDKTS..GKCSKE..LG-E.VdEEDDCCQNPNYGYQKID..GP-CQSCGP.
A0A673MA36_9TELE/21-68               ...EMVECFSSFTLST..GKCGDL..LG-Q.V.EKNSCCLNPSYGYKEAD..GV-CRFCG-r
A0A3P8VEI0_CYNSE/18-65               ...ECVRCFAGFNLTL..GQCSRE..VG-D.V.NQKECCQNPDYGFLTED..GS-CQSCG-v
L5L193_PTEAL/27-76                   ...DPVLCFTQYEESL..GKCKSL..LGEG.V.RVEDCCLNTAYAFQEPG..SKLCQACR-d
A0A2R9BZ89_PANPA/28-77               ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVEDCCLNTAFAYQKRS..GGLCQPCRS.
A0A4W5LU67_9TELE/21-68               ...QEVNCYSRFDS--..GNCDDLwlLG-E.V.AMDDCCLNPHYGYIGAD..GK-CKYCGP.
A0A4W2BZ28_BOBOX/27-76               ...DPVFCFAQYEEST..GKCKDL..LGRG.V.SVEDCCLNAGYAFQKPG..SNLCMACR-l
A0A671N066_9TELE/21-68               ...EMVECFSSFTLST..GKCGDL..LG-Q.V.EKNSCCLNPSYGYKEAD..GV-CRFCG-r
A0A096LRQ3_POEFO/18-65               ...ECVRCFGSFDLTT..GECSED..LG-D.V.NEDDCCQNSQYGYEAED..GS-CRSCGP.
A0A6I9IJ95_VICPA/85-134              ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SAEDCCLNADYAFQESS..HSFCMACR-f
A0A5F4WLJ9_CALJA/28-77               ...DPVFCFSQYEESS..GKCKGL..LGGG.V.SLKDCCLNTAYAYQERS..SGLCQPCRS.
A0A4W6C4Q1_LATCA/24-71               ...ECVRCFARFDLTS..GRCDEE..LG-E.V.DEDDCCQNPQYGYQATG..GV-CQSCGP.
A0A6F9BJG8_9TELE/21-66               ...QEVKCYSRFDN--..GDCDYL..LG-E.V.TMEDCCLNPHYGYIGAD..GK-CKFCGP.
A0A5N3VXQ8_MUNRE/25-74               ...DSVQCFAQYEEST..GKCKDF..LGGG.V.RVEDCCLNAAYAFQKPG..SKLCMACR-l
H2RMQ3_TAKRU/56-101                  .ag--ARCFSQFNQ--..GQCVGE..LG-E.V.EEDDCCQNPHYGHKDTD..GQ-CRSCGP.
A0A672FNX1_SALFA/32-79               ..d-GVRCFAHFNVTS..GVCDEE..LG-E.V.GKDSCCQNPAYGYLATD..GV-CQFCGP.
A0A2U3VP49_ODORO/20-69               ..v-PVLCFTHYEESS..GTCKDL..LGGG.V.SVEVCCLNPAYGFQEPG..SKLCQACR-l
A0A672F1M8_SALFA/16-63               ..n-GVRCFAHFNVTS..GVCDEE..LG-E.V.GKDSCCQNPAYGYLATD..GV-CQFCGP.
A0A2K6R4Y4_RHIRO/28-77               ...DPVLCFTQYEESS..SKCKGF..LGGG.V.SVKDCCLNTAYAYQERN..GGLCQPCRS.
H0X555_OTOGA/27-75                   ...DPVLCFTQHEESS..RKCSGF..LG-S.V.SVEDCCLNTAFAFQKDG..SKLCQTCR-a
A0A2J8IU45_PANTR/28-77               ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVEDCCLNTAFAYQKRS..GGLCQPCRS.
K7GQR1_PIG/59-108                    ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SLEDCCLNADYAFQETS..SKFCMPCRP.
A0A6A1Q1Y1_BALPH/50-99               ...DPVLCFTQYEEST..GKCKGL..LGGG.V.STEDCCLNADYAFQEPG..SKHCMACR-l
A0A402FNU9_9SAUR/44-93               .ea--SLCYEIFDDSS..GSCVQL..LGDG.V.DQEDCCLNHQHGFRRQK..DAPCEACRP.
A0A437CEF7_ORYJA/21-68               ...EAVRCFAVFNTTT..GECHDE..LG-D.V.DLDDCCHNPHYGYLTEE..GT-CQFCGP.
A0A6P3RRG3_PTEVA/27-76               ...DPVLCFTQYEDSS..GKCKSL..LGEG.V.RVEDCCLNTAYAFQEPG..SKLCQACRS.
A0A3P9B8L2_9CICH/21-68               ...DCVRCFTRFDLNT..GECNEE..IG-E.V.DEDDCCQNPNYGYMETD..GQ-CESCG-l
A0A4W2BZ21_BOBOX/27-76               ...DPVFCFAQYEEST..GKCKDL..LGRG.V.SVEDCCLNAGYAFQKPG..SNLCMACR-l
F7IDK9_CALJA/28-77                   ...DPVFCFSQYEESS..GKCKGL..LGGG.V.SLKDCCLNTAYAYQERS..SGLCQPCRS.
A0A3Q7XR31_URSAR/24-73               ..v-PVLCFTQYEESS..GKCKGL..LGGG.V.SVEDCCLNPAYGFQEPG..SKLCHACRS.
A0A3B5QCJ7_XIPMA/67-114              ...ECVRCFGSFDLTT..GECSED..LG-D.V.DEDDCCQNSQYGYEAED..GS-CHSCGP.
A0A5A9NZ94_9TELE/21-68               ..q-MAQCFTEFSRSN..GTCGDL..LG-E.V.EIQDCCINPDYGYVEAD..GV-CKSCG-r
A0A7R5L7L1_9PASS/21-73               ..t-PVWCFARLEEAEggGACVEL..LSDEpV.PLADCCLNPAYGYRLRP..HGRCLSCRQ.
A0A671W3L5_SPAAU/110-157             ...ECVRCFVRFNPTL..GQCDEE..LG-E.V.DEDDCCQNPQYGYQAAD..GV-CHSCGP.
A0A4W3GNM8_CALMI/23-71               ...EMVYCYQEIDPMT..GHCKNL..IGKD.I.ERSDCCMNMNYSVKLNP..EDTCKSCR-.
A0A315W5G8_GAMAF/63-101              ..v----------QRS..GECSKD..LG-N.V.DQDDCCQNSRFGYEAED..GS-CHSCGP.
A0A7R5L7K2_9PASS/21-73               ..t-PVWCFARLEEAEggGACVEL..LSDEpV.PLADCCLNPAYGYRLRP..HGRCLSCRQ.
A0A671W675_SPAAU/105-152             ..g-CVRCFAQFNPTL..GQCDEE..LG-E.V.DEDDCCQNPQYGYQAAD..GV-CRSCGP.
A0A452S6H3_URSAM/3-46                ..g-------TYEESS..GKCKGL..LGGG.V.SVEDCCLNPAYGFQEPG..SKLCHACRS.
A0A3Q1MHU8_BOVIN/14-63               ...DPVFCFAQYEEST..GKCKDL..LGRG.V.SVEDCCLNAGYAFQKPG..SNLCMACR-l
A0A803K999_XENTR/23-72               ...EEVVCFSDFDERT..GGCGEL..LGGG.V.SEEDCCLNIKYSFKRGA..DAPCQACRP.
A0A673VL87_SURSU/133-182             ...DPVFCFTQYEEAS..GKCTGL..LGGG.V.SVKDCCLNPTFAFQKPG..SNLCQACR-l
A0A3P8SIX7_AMPPE/21-68               ...ECVRCFARFHLPS..GECDEE..LG-E.V.DKDDCCQNPNYGYQETD..GT-CQSCGP.
A0A6P6PJ83_CARAU/21-68               qla---DCFASFTLST..GKCSDL..LG-Q.V.KKDECCLNPSYGYKEAD..GV-CKSCG-r
F6ZPU1_ORNAN/14-65                   ...ESVLCYSKFDEVM..GQCKEL..LGAG.V.SQEDCCMNPNYAFQPEGvpKGFCQSCRP.
G1U9S1_RABIT/26-75                   ...DPVVCFTEYDEPS..GKCKGL..LGGG.V.SVEHCCLNAAYAFQEPG..SGLCHACRS.
A0A4W5LVW5_9TELE/24-71               ...QEVNCYSRFDS--..GNCDDLwlLG-E.V.AMDDCCLNPHYGYIGAD..GK-CKYCGP.
A0A3P8YDK5_ESOLU/20-67               ...QEVKCYSKFDKNL..GNCANL..LG-N.V.GMDDCCLNTHYGYTGDD..GK-CKSCGP.
F1RWV1_PIG/23-72                     ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SLEDCCLNADYAFQETS..SKFCMPCRP.
G1Q8L3_MYOLU/34-83                   ...EPVLCFTQYEESS..GKCKGL..LGGG.V.RVQDCCLNAAYAFQEPG..SKLCHPCRS.
A0A3Q3WMH5_MOLML/11-58               ..k-CVRCFARFDQVL..GECNDE..LG-D.V.DEDDCCQNPRYGYQDNN..DT-CKYCGP.
A0A3P9B8A5_9CICH/21-68               ...DCVRCFTRFDLNT..GECNEE..IG-E.V.DEDDCCQNPNYGYMETD..GQ-CESCG-l
A0A4X2KZC2_VOMUR/32-81               ...ESVRCFSNFEEAS..SQCQGL..LGEG.V.SKDACCLNAAHGFQIPG..SPTCQACG-a
L8Y675_TUPCH/33-81                   ...DPVLCFSRYEE-S..GKCKDL..LGGG.V.SVEDCCLNAAYGFQKQG..SGLCQPCRS.
A0A452FGS4_CAPHI/62-111              ...DSVLCFAQYEEST..GKCKDL..LGGG.V.SMKNCCLNANYAFQKPG..SKLCMACR-l
A0A6J3QUY0_TURTR/28-77               ...DPVLCFTQYEEST..GKCKGL..LGGG.V.STEDCCLNADYAFQELG..SKLCMACR-l
A0A7R5L7L5_9PASS/21-73               ..t-PVWCFARLEEAEggGACVEL..LSDEpV.PLADCCLNPAYGYRLRP..HGRCLSCRQ.
G3R040_GORGO/28-77                   ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVEDCCLNTAFAYQKRS..GGLCQPCRS.
A0A3Q1FH83_9TELE/21-68               ...ECVRCFARFHLSS..GQCDEE..IG-E.V.DEDDCCQNPKYGYQATD..GT-CQSCGP.
A0A674BBR7_SALTR/24-71               ...QEVNCYSSFDS--..GNCDDLwlLG-E.V.TMDDCCLNPHYGYIGAD..GK-CKSCGP.
G3STF5_LOXAF/23-72                   ...DPVLCFTQYEESS..SKCKDL..LGGG.V.SAEDCCLNAAYAFQEQG..SGLCQACRS.
A0A455B260_PHYMC/27-76               ...DPVFCFTHYEEST..GKCKDL..LGGG.V.STEDCCLNADYAFQEPH..RKLCMACR-l
A0A6P3VLR8_CLUHA/25-72               ..q-LVPCYSKFDMNT..GTCNEL..IG-N.V.TQGHCCFNSNYGFRKES..GK-CMSCRQ.
A0A1A6H3G5_NEOLE/46-95               ...DPVLCFTQYEESS..GKCKGL..LGGD.I.SVEDCCLNAAYAFQEHT..GGLCQACRS.
A0A2Y9JS01_ENHLU/22-71               ..a-TVFCYTKYEESS..GMCKGL..LGGG.V.SVKDCCLNPAYGFQEPG..SKLCQACR-l
A0A673VKY4_SURSU/133-182             ...DPVFCFTQYEEAS..GKCTGL..LGGG.V.SVKDCCLNPTFAFQKPG..SNLCQACR-l
A0A3Q4BHH2_MOLML/25-72               ..h-CVRCFARFDQVL..GECNDE..LG-D.V.DEDDCCQNPRYGYQDNN..DT-CKYCGP.
A0A2U3XL84_LEPWE/23-72               ..v-PVLCFTHYEESS..GICKGL..LGGG.V.SVEDCCLNPAYGFQEPG..SKLCQACRP.
A0A6G1BFR2_CROCR/30-79               ...DPVFCFTQYEEAS..GKCMGL..LGGG.V.SVKDCCLNPAYAFQKPG..SKLCQACR-l
A0A673FQJ2_9TELE/21-68               ...QMVDCFSSFTLST..GKCSGL..LG-Q.V.KKDDCCLNSNYGYKEAD..GV-CRSCG-r
W5PTL2_SHEEP/26-75                   ...DSVLCFAQYEEST..GKCKDL..LGGG.V.SMKNCCLNANYAFQKPG..SKLCMACR-l
A0A4W5LV63_9TELE/14-61               ..w-EVNCYSRFDS--..GNCDDLwlLG-E.V.AMDDCCLNPHYGYIGAD..GK-CKYCGP.
G3PPI0_GASAC/21-68                   ...QGVRCFARFYLSL..GQCDEE..LG-E.V.DEEDCCQNPQYGYQTTD..GV-CRSCGS.
A0A383ZYY3_BALAS/28-77               ...DPVLCFTQYEEST..GQCKGL..LGGG.V.STEDCCLNADYAFQEPG..SKLCMACR-l
A0A6P6N9D3_CARAU/474-521             ...QKVECFSSFSLSS..GKCGNL..LG-E.V.GKEDCCLNPSYGFKEAD..GV-CRSCG-y
A0A341BUM4_NEOAA/28-77               ...DPVLCFTQYEEST..GKCKGL..LGGG.V.STEDCCLNADYAFQEPG..SKLCMACR-l
A0A384CEV5_URSMA/1-46                ...----CFTQYEESS..GKCKGL..LGGG.V.SVEDCCLNPAYGFQEPG..SKLCHACRS.
A0A6F9B164_9TELE/6-55                ..p-EVKCYTRFDGDS..GNCDDLwlLG-E.V.TMDDCCLNPHYGYIGSD..GK-CKSCH-l
PROP_CAVPO/27-76                     ...DPVLCFSQYEDSS..SKCKDL..LGKD.V.SLEDCCLNAAYAFKERD..NGHCQACRS.
A0A3Q3X1N4_MOLML/25-72               ..h-CVRCFARFDQVL..GECNDE..LG-D.V.DEDDCCQNPRYGYQDNN..DT-CKYCGP.
L5LE69_MYODS/27-76                   ...EPVLCFTQYEESS..GKCKGL..LGGG.V.RVQDCCLNAAYAFQEPG..SKLCQPCRS.
A0A672KTE7_SINGR/21-68               ...QMVDCFSSFTLST..GKCSGL..LG-Q.V.KKDDCCLNTNYGYEEAD..GV-CRSCG-r
A0A672QG82_SINGR/21-68               ...EMVECFSSFTLST..GKCGDL..LG-Q.V.EKNSCCLNPSYAYKEAD..GV-CRFCG-r
A0A671W494_SPAAU/110-157             ...ECVRCFVRFNPTL..GQCDEE..LG-E.V.DEDDCCQNPQYGYQAAD..GV-CHSCGP.
F7CGG5_MACMU/28-77                   ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVKDCCLNTAYAYQERN..GGLCQPCRS.
A0A6J2W6Z7_CHACN/20-67               ...EVVECYGQFDPSS..GRCGNV..LG-A.V.DMDDCCLNVDYGYMDTD..GN-CKSCR-k
A0A672F1L8_SALFA/24-71               .yg--VRCFAHFNVTS..GVCDEE..LG-E.V.GKDSCCQNPAYGYLATD..GV-CQFCGP.
A0A2Y9LYJ7_DELLE/28-77               ...DPVLCFTQYEEST..GKCKGL..LGGG.V.STEDCCLNADYAFQEPG..SKLCMACR-l
A0A6A5EMZ0_PERFL/21-68               ...ECVRCFARFDLNL..GQCDEE..LG-E.L.DEDDCCQNPEYGYQGPD..GV-CRGCGP.
PROP_HUMAN/28-77                     ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVEDCCLNTAFAYQKRS..GGLCQPCRS.
#=GR PROP_HUMAN/28-77          SS    ...-EEEEEEEEETTT..TEEEEE..EEEE.E.EHHHHTTSTT-EEESTT..TSEEEESSS.
A0A6P3FBC1_OCTDE/27-76               ...DSVLCFTQYEESS..GRCKGL..LGKD.I.HVQDCCLNAAYAFKKHD..SGHCQACRS.
A0A5N4C0V7_CAMDR/32-81               ...DPVLCFTQYEESS..GKCKGL..LGGG.V.SVEDCCLNADYAFQESS..HSFCMACS-f
A0A1L8F5K8_XENLA/22-71               ...EEVVCYSDFDERS..GGCTQY..LGEG.V.SEGDCCLNIKYSFKRDP..GAPCESCRP.
A0A091CXT7_FUKDA/27-76               ...DPVLCFSQYEDST..GRCQGP..LGRD.I.SVEDCCLNAAYAFQERD..GGLCQACRS.
A0A3Q2G1M6_CYPVA/22-69               ...ECVRCFASFDLTT..GECSAE..LG-E.V.ELDDCCQNSQYGYQEED..GS-CHSCG-v
A0A671W644_SPAAU/209-256             ...ECVRCFAQFNQTL..GQCDEE..LG-E.V.DEDDCCQNPQYGYQAAD..GV-CHSCGP.
A0A1U7UMN2_CARSF/27-76               ...DPVVCFTQYEESS..GECKNL..LGRG.V.SVEDCCLNAAYAYQEHG..SEFCQACRS.
A0A674MS28_TAKRU/22-67               .ag--ARCFSQFNQ--..GQCVGE..LG-E.V.EEDDCCQNPHYGHKDTD..GQ-CRSCGP.
M3ZNP1_XIPMA/67-114                  ...ECVRCFGSFDLTT..GECSED..LG-D.V.DEDDCCQNSQYGYEAED..GS-CHSCGP.
A0A4W5LV25_9TELE/21-68               ...QEVNCYSRFDS--..GNCDDLwlLG-E.V.AMDDCCLNPHYGYIGAD..GK-CKYCGP.
A0A5N5NLK8_PANHP/23-70               ...QMVQCYAAFRPTD..GTCSNI..LG-Q.V.PLDDCCMNPAYGYQDKG..SD-CKSCR-y
A0A6P6IN05_PUMCO/29-78               ...DPVLCFTQYEEAT..GKCMGL..LGGG.V.SVNDCCLNPAYAFQKPG..SKLCQACRP.
A0A670YVS5_PSETE/25-74               ..v-NVLCYKTFDEIS..GTCSNL..LGDG.V.SQEDCCLNDQYGFQLTE..NGACQSCR-g
#=GC SS_cons                         ...-EEEEEEEEETTT..TEEEEE..EEEE.E.EHHHHTTSTT-EEESTT..TSEEEESSS.
#=GC seq_cons                        ...-sVhCFopa-poo..GcCpsL..LG.s.V.sh-DCCLNssYuaQcss..us.CpuCt..
//
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