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Database: Pfam
Entry: Tat
LinkDB: Tat
Original site: Tat 
#=GF ID   Tat
#=GF AC   PF00539.21
#=GF DE   Transactivating regulatory protein (Tat)
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   SCOP
#=GF GA   22.50 22.50;
#=GF TC   24.00 24.00;
#=GF NC   22.40 19.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Tat_(HIV)
#=GF RN   [1]
#=GF RM   7515512
#=GF RT   Structure of the equine infectious anemia virus Tat protein. 
#=GF RA   Willbold D, Rosin-Arbesfeld R, Sticht H, Frank R, Rosch P; 
#=GF RL   Science 1994;264:1584-1587.
#=GF RN   [2]
#=GF RM   7502045
#=GF RT   Solution structure of a bovine immunodeficiency virus Tat-TAR
#=GF RT   peptide-RNA complex. 
#=GF RA   Puglisi JD, Chen L, Blanchard S, Frankel AD; 
#=GF RL   Science 1995;270:1200-1203.
#=GF RN   [3]
#=GF RM   9126842
#=GF RT   Solution structure of the HIV-2 TAR-argininamide complex. 
#=GF RA   Brodsky AS, Williamson JR; 
#=GF RL   J Mol Biol 1997;267:624-639.
#=GF RC   Original characterisation of Tat as a novel RNA-binding factor
#=GF RN   [4]
#=GF RM   2478293
#=GF RT   Tat trans-activates the human immunodeficiency virus through a
#=GF RT   nascent RNA target. 
#=GF RA   Berkhout B, Silverman RH, Jeang KT; 
#=GF RL   Cell 1989;59:273-282.
#=GF RC   Review of Tat function
#=GF RN   [5]
#=GF RM   10506122
#=GF RT   Multifaceted activities of the HIV-1 transactivator of
#=GF RT   transcription, Tat. 
#=GF RA   Jeang KT, Xiao H, Rich EA; 
#=GF RL   J Biol Chem 1999;274:28837-28840.
#=GF DR   INTERPRO; IPR001831;
#=GF DR   SCOP; 1tvs; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The retroviral Tat protein binds to the Tar RNA [4].  This
#=GF CC   activates  transcriptional initiation and elongation from the
#=GF CC   LTR promoter. Binding is mediated by an arginine rich region.
#=GF SQ   38
#=GS B3CKG2_SIV/49-107      AC B3CKG2.1
#=GS TAT_HV1MA/2-64         AC P04613.1
#=GS TAT_HV1MA/2-64         DR PDB; 1K5K A; 2-64;
#=GS O57293_9PLVG/2-64      AC O57293.1
#=GS TAT_SIVMB/2-64         AC Q1A264.1
#=GS A0A437P497_9RHIZ/1-57  AC A0A437P497.1
#=GS TAT_HV1YF/2-64         AC O91083.1
#=GS TAT_SIVTN/2-63         AC Q8AIH8.1
#=GS TAT_HV193/2-64         AC O70889.1
#=GS TAT_HV192/2-64         AC O12161.1
#=GS P89907_SIVTA/9-66      AC P89907.1
#=GS Q9Q6W1_9HIV1/2-64      AC Q9Q6W1.1
#=GS Q9YX52_9HIV1/2-64      AC Q9YX52.1
#=GS TAT_HV1MV/2-61         AC P0C1K2.1
#=GS A0A502BKH9_9RHIZ/3-37  AC A0A502BKH9.1
#=GS Q8AII5_SIV/14-70       AC Q8AII5.1
#=GS TAT_HV2BE/40-91        AC P18098.1
#=GS TAT_SIVSP/38-93        AC P19507.1
#=GS Q900A7_9HIV1/2-64      AC Q900A7.1
#=GS TAT_HV1B1/2-64         AC P69697.1
#=GS TAT_HV1B1/2-64         DR PDB; 5L1Z D; 2-49;
#=GS TAT_SIVEK/2-64         AC Q1A246.1
#=GS A0A1B4WRK0_SIV/12-62   AC A0A1B4WRK0.1
#=GS TAT_JEMBR/22-82        AC Q82854.1
#=GS TAT_JEMBR/22-82        DR PDB; 1ZBN B; 1-17;
#=GS TAT_HV1BR/2-64         AC P04610.1
#=GS TAT_HV1BR/2-64         DR PDB; 1JFW A; 2-64;
#=GS TAT_HV1A2/2-64         AC P04614.1
#=GS TAT_HV1RH/2-64         AC P05908.1
#=GS TAT_HV2UC/38-93        AC Q76632.1
#=GS TAT_SIVCZ/2-65         AC P17285.1
#=GS TAT_HV1H2/2-64         AC P04608.2
#=GS TAT_HV1H2/2-64         DR PDB; 3MI9 C; 2-49;
#=GS TAT_HV1H2/2-64         DR PDB; 6CYT D; 2-48;
#=GS TAT_HV1H2/2-64         DR PDB; 4OR5 H; 2-48;
#=GS TAT_HV1H2/2-64         DR PDB; 6MCE B; 44-60;
#=GS TAT_HV1H2/2-64         DR PDB; 3MIA C; 2-48;
#=GS TAT_HV1H2/2-64         DR PDB; 4OR5 C; 2-48;
#=GS TAT_HV1H2/2-64         DR PDB; 6MCF B; 44-60;
#=GS Q87111_SIVSA/6-69      AC Q87111.1
#=GS TAT_HV1EL/2-64         AC P04611.1
#=GS TAT_HV1ET/2-42         AC Q75005.1
#=GS TAT_HV1YB/2-64         AC Q9IDV5.1
#=GS TAT_HV190/2-64         AC O70899.1
#=GS TAT_HV2RO/40-91        AC P04605.1
#=GS W8EG24_9PLVG/2-64      AC W8EG24.1
#=GS TAT_HV1Y2/2-64         AC P35965.1
#=GS TAT_HV1AN/2-62         AC P0C1K1.1
#=GS TAT_HV1B9/2-64         AC Q73370.1
B3CKG2_SIV/49-107                 glqeireelsretls-------------------..PCNHqCRCKKCIFSCQLCFLQKGLGISYH..S.YSKK-----------tnkdksdast
TAT_HV1MA/2-64                    ..............d-PVDPNLEPWNHPGSQPRT..PCNK.CYCKKCCYHCQMCFITKGLGISYG..R.KKRRQRRRPPQGNQ-a.........
#=GR TAT_HV1MA/2-64         SS    ..............T-TS--SS-TT-----TTT-..S-TT.SSS--SS---S------S-SSSS-..S.S-------S-SSHH-H.........
O57293_9PLVG/2-64                 ...............EPVDPRLEPWKHPGSKPKT..ACTN.CYCKKCCFHCQVCFITKALGISYG..R.KKRRQRRRAHQNSQT..........
TAT_SIVMB/2-64                    ...............EPIDPNLEPWNHPGSQPKT..ACNN.CYCKQCCYHCQLCFTKKGLGISYG..R.RKRKQRRRTSESSQ-n.........
A0A437P497_9RHIZ/1-57             ....mpaltawlsdt---------------PGRT..SCTCwCSLNLCCM-GSVSFVGAGRGIGPG..R.ARRQARRRALR----aa........
TAT_HV1YF/2-64                    ...............EPVDPRLEPWNHPGSQPKT..ACNN.CYCKRCCYHCLYCFTKKGLGISYG..R.KKRSQRRRTPQSSK-s.........
TAT_SIVTN/2-63                    ...............NPIDPQVAPWEHPGAAPET..PCTN.CYCKKCCFHCPVCFTKKALGISYG..R.KRR-GRKSAVH----stnn......
TAT_HV193/2-64                    .............el--VDPNLDPWNHPGSQPTT..PCTR.CYCKWCCFHCYWCFTTKGLGISYG..R.KKRRQRPRTPQSSQ-i.........
TAT_HV192/2-64                    ...............EPVDPNLEPWNHPGSQPKT..ACNN.CYCKRCSYHCLVCFQTKGLGISYG..R.KKRRQRRSAPPSS--ed........
P89907_SIVTA/9-66                 ......aesllqdlh---------------RPLT..PCTNkCFCKRCCYHCQVCFLQKGLGITYH..V.SRIRRPKKNHSNH--qn........
Q9Q6W1_9HIV1/2-64                 ...............EPVDPRLEPWKHPGSQPKT..ACTN.CYCKKCCLHCQVCFMKKGLGISYG..R.KKRRQRRRAPQDNQT..........
Q9YX52_9HIV1/2-64                 ...............EPVDPDLEPWNHPGSQPTT..DCNK.CFCKKCCWHCQVCFLKKGLGISYG..R.KKRKHRRGSLQGSK-g.........
TAT_HV1MV/2-61                    ..............d-PVDPEMPPWHHPGSKPQT..PCNN.CYCKRCCYHCYVCFTKKGLGISHG..R.KKR--RRPA------aaasy.....
A0A502BKH9_9RHIZ/3-37             ..........llrts----------SGPGSQPKTstACTR.CLMKTTCLHFVLC-----------..-.---------------tt........
Q8AII5_SIV/14-70                  .......dvtpydpf--------------RDRTT..PCDT.CYCKRCCYHCQLCFLQKALGVHYH..AyRNRRSRQRL------lekis.....
TAT_HV2BE/40-91                   ..........laqlh---------------RPLE..PCTNkCYCKRCSFHCQLCFSKKGLGISYE..R.KGR--RRRTPRKTKT..........
TAT_SIVSP/38-93                   ........eilsqly---------------RPLE..ACYNkCYCKRCCYHCQHCFLKKGLGICYE..Q.QRR----RTPKKTK-antss.....
Q900A7_9HIV1/2-64                 ...............EPVDPRLEPWKHPGSQPKT..ACTN.CYCKKCCFHCQVCFMTKALGISYG..R.KKRRQRRRAHQNSQT..........
TAT_HV1B1/2-64                    ...............EPVDPRLEPWKHPGSQPKT..ACTN.CYCKKCCFHCQVCFITKALGISYG..R.KKRRQRRRPPQGSQT..........
#=GR TAT_HV1B1/2-64         SS    ...............----TTS-GGGS-BSS-SS..----.--STTGGGSSHHHHHHTTS-----..-.XXXXXXXXXXXXXXX..........
TAT_SIVEK/2-64                    ...............EPVDPELEPWNHPGSQPKT..ACNN.CHCKVCCYHCVYCFTKKGLGISYG..R.KKRSQRRRTPQSNK-s.........
A0A1B4WRK0_SIV/12-62              ............plg---------WKTDNLQP--..-CNNkCFCKRCCYHCQLCFLQKGLGINYA..P.RPRRKK---------vilpy.....
TAT_JEMBR/22-82                   .......pkcwlfwn------------TCAGPRR..VCPK.CSCPICVWHCQLCFLQKGLGIRHDgrR.KKR-GTR--------gkgrkihya.
#=GR TAT_JEMBR/22-82        SS    .......XXXXXXXX------------XXXXXXX..XXXX.XXXXXXXXXXXXXXXXXXXXXXXX--S.-----SS--------SSS-----X.
TAT_HV1BR/2-64                    ...............EPVDPRLEPWKHPGSQPKT..ACTT.CYCKKCCFHCQVCFTTKALGISYG..R.KKRRQRRRPPQGSQT..........
#=GR TAT_HV1BR/2-64         SS    ...............-S-SS--SS-----SSS-S..SSS-.BTTTTBTSSSS--STTTSEETTEE..S.S---------SSS--..........
TAT_HV1A2/2-64                    ...............EPVDPNLEPWKHPGSQPRT..ACNN.CYCKKCCFHCYACFTRKGLGISYG..R.KKRRQRRRAPQDSQT..........
TAT_HV1RH/2-64                    ...............EPVDPRLEPWKHPGSQPKT..ACNN.CYCKKCCYHCQVCFLTKGLGISYG..R.KKRRQRRGPPQGSQT..........
TAT_HV2UC/38-93                   ........eilsqly---------------RPLE..ACDNkCYCKKCCYHCQLCFLKKGLGIWYD..H.SRKRSSKRAK-----vtass.....
TAT_SIVCZ/2-65                    ..............d-PIDPDLEPWKHPGSQPRT..VCNN.CYCKACCYHCIYCFTKKGLGISYG..R.KKRTTRRRTA-----pagskn....
TAT_HV1H2/2-64                    ...............EPVDPRLEPWKHPGSQPKT..ACTN.CYCKKCCFHCQVCFITKALGISYG..R.KKRRQRRRAHQNSQT..........
#=GR TAT_HV1H2/2-64         SS    ...............XXXXTTSXGGGSXBXSXSS..XXXS.XXSHHHHTSSHHHHHHTTT---SS..-.-BTTTBSTTT-XXXX..........
Q87111_SIVSA/6-69                 .earpqvweelqeel--------------HRPLQ..ACDNtCFCKVCCFHCILCFHKKALGIRYY..V.PRP---RRAS-----kkishnqv..
TAT_HV1EL/2-64                    ..............d-PVDPNLEPWNHPGSQPRT..PCNK.CHCKKCCYHCPVCFLNKGLGISYG..R.KKRRQRRGPPQGG--qa........
TAT_HV1ET/2-42                    ...............EPVDPNLEPWNHPGSQPKT..ACNQ.CYCKKCSYHCLVCFLTKA------..-.---------------..........
TAT_HV1YB/2-64                    ...............EPVDPRLEPWNHPGSQPKT..ACNK.CYCKKCCYHCMCCFTKKGLGISYG..R.KKRSQRRRPPKSSK-d.........
TAT_HV190/2-64                    ..............d-PVDPKLEPWNHPGSQPQT..ACNN.CYCKKCCYHCQMCFLKKGLGISYG..R.KKRSQRHRTPAS---lqd.......
TAT_HV2RO/40-91                   ..........lsqly---------------RPLE..TCNNsCYCKRCCYHCQMCFLNKGLGICYE..R.KGR--RRRTPKKTKT..........
W8EG24_9PLVG/2-64                 ...............EPVDPNLEPWKHPGSQPKT..ACTN.CYCKKCCFHCQVCFTKKGLGISYG..R.KKRRHRRGSPQSSK-d.........
TAT_HV1Y2/2-64                    ...............EPVDPNLEPWKHPGSQPRT..ACNN.CYCKKCCFHCQVCFTKKGLGISYG..R.KKRRQRRRPPQDSQT..........
TAT_HV1AN/2-62                    ..............d-PVDPEVPPWHHPGSQPQI..PCNN.CYCKRCCYHCYVCFVRKGLGISYG..R.KKR-GR---------paaashpd..
TAT_HV1B9/2-64                    ...............EPVNPSLEPWKHPGSQPKT..ACTN.CYCKKCCFHCQACFITKGLGISYG..R.KKRRQRRRPPQDSQT..........
#=GC SS_cons                      ..............TXTSSTTSSGGGSXBSSTSS..SSTT.CTSTTCCCSSCHHHHHTTCCTTSC..S.SBTTTCSTTTSSCHXCSS.......
#=GC seq_cons                     ................PVDPpL-PWpHPGSQP+T..uCsN.CYCK+CCaHCQlCFhpKGLGISYG..R.KKRppRRRsspts............
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