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Database: Pfam
Entry: Tax
LinkDB: Tax
Original site: Tax 
#=GF ID   Tax
#=GF AC   PF02959.19
#=GF DE   HTLV Tax
#=GF PI   HTLV_tat;
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Jeang K;
#=GF SE   Pfam-B_1456 (release 6.4)
#=GF GA   27.00 27.00;
#=GF TC   238.80 238.40;
#=GF NC   20.30 19.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11325603
#=GF RT   Functional activities of the human T-cell leukemia virus type I
#=GF RT   Tax oncoprotein: cellular signaling through NF-kappaB. 
#=GF RA   Jeang K; 
#=GF RL   Cytokine Growth Factor Rev 2001;12:207-217.
#=GF DR   INTERPRO; IPR004120;
#=GF DR   SCOP; 1ao7; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Human T-cell leukaemia virus type I (HTLV-I) is the etiological
#=GF CC   agent for adult T-cell leukaemia (ATL), as well as for tropical
#=GF CC   spastic paraparesis (TSP) and HTLV-I associate myelopathy (HAM).
#=GF CC   A biological understanding of the involvement of HTLV-I and in
#=GF CC   ATL has focused significantly on the workings of the
#=GF CC   virally-encoded 40 kDa phospho-oncoprotein, Tax. Tax is a
#=GF CC   transcriptional activator. Its ability to modulate the
#=GF CC   expression and function of many cellular genes has been reasoned
#=GF CC   to be a major contributory mechanism explaining HTLV-I-mediated
#=GF CC   transformation of cells. In activating cellular gene expression,
#=GF CC   Tax impinges upon several cellular signal-transduction pathways,
#=GF CC   including those for CREB/ATF and NF-kappaB [1].
#=GF SQ   8
#=GS TAX_HTL32/3-224      AC Q0R5R1.1
#=GS Q9QR98_9DELA/22-243  AC Q9QR98.1
#=GS TAX_HTL1A/3-224      AC P03409.2
#=GS Q9QR97_9DELA/3-224   AC Q9QR97.1
#=GS TAX_HTL1C/3-224      AC P14079.2
#=GS TAX_HTL1C/3-224      DR PDB; 2AV1 C; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 1IM3 C; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 2AV7 F; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 5IRO V; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 1HHK C; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 1IM3 O; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 5IRO B; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 2AV1 F; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 5IRO F; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 1HHK F; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 1BD2 C; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 6UZ1 H; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 6UZ1 C; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 5IRO N; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 1IM3 G; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 5IRO R; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 1AO7 C; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 1IM3 K; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 2AV7 C; 1-9;
#=GS TAX_HTL1C/3-224      DR PDB; 5IRO J; 1-9;
#=GS TAX_HTLV2/3-224      AC P03410.2
#=GS Q9WS52_9STL1/1-116   AC Q9WS52.1
#=GS TAX_HTL3P/3-224      AC Q4U0X7.2
TAX_HTL32/3-224                 HFPGFGQSLLYGYPVYVFGDCVQADWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVVSSALQYLIPRLPSFPTQRTTRTLKVLTPPTTAATPKIPPSFFHAVKKHTPFRNNCLELTLGEQLPAMSFPDPGLRPQNIYTMWGSSVVCLYLYQLSPPMTWPLIPHVIFCHPEQLGAFLTRVPTKRLEELLYKIFLSTGAIIILPENCFPTTLFQPTRAP
Q9QR98_9DELA/22-243             HFPGFGQSLLFGYPVYVFGDCVQGDWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVIGSALQFLIPRLPSFPTQRTSKTLKVLTPPITHTTPNIPPSFLQAMRKYSPFRNGYMEPTLGQHLPTLSFPDPGLRPQNLYTLWGGSVVCMYLYQLSPPITWPLLPHVIFCHPGQLGAFLTNVPYKRIEELLYKISLTTGALIILPEDCLPTTLFQPVKAP
TAX_HTL1A/3-224                 HFPGFGQSLLFGYPVYVFGDCVQGDWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVIGSALQFLIPRLPSFPTQRTSKTLKVLTPPITHTTPNIPPSFLQAMRKYSPFRNGYMEPTLGQHLPTLSFPDPGLRPQNLYTLWGGSVVCMYLYQLSPPITWPLLPHVIFCHPGQLGAFLTNVPYKRIEELLYKISLTTGALIILPEDCLPTTLFQPARAP
Q9QR97_9DELA/3-224              HFPGFGQSLLFGYPVYVFGDCVQGDWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVIGSALQFLIPRLPSFPTQRTSKTLKVLTPPITHTTPNIPPSFLQAMRKYSPFRNGYMEPTLGQHLPTLSFPDPGLRPQNLYTLWGGSVVCMYLYQLSPPITWPLLPHVIFCHPGQLGAFLTNVPYKRIEELLYKISLTTGALIILPEDCLPTTLFQPVKAP
TAX_HTL1C/3-224                 HFPGFGQSLLFGYPVYVFGDCVQGDWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVIGSALQFLIPRLPSFPTQRTSKTLKVLTPPITHTTPNIPPSFLQAMRKYSPFRNGYMEPTLGQHLPTLSFPDPGLRPQNLYTLWGGSVVCMYLYQLSPPITWPLLPHVIFCHPGQLGAFLTNVPYKRIEKLLYKISLTTGALIILPEDCLPTTLFQPARAP
#=GR TAX_HTL1C/3-224      SS    XXXXXXXX---SS----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
TAX_HTLV2/3-224                 HFPGFGQSLLYGYPVYVFGDCVQADWCPVSGGLCSTRLHRHALLATCPEHQLTWDPIDGRVVSSPLQYLIPRLPSFPTQRTSRTLKVLTPPTTPVSPKVPPAFFQSMRKHTPYRNGCLEPTLGDQLPSLAFPEPGLRPQNIYTTWGKTVVCLYLYQLSPPMTWPLIPHVIFCHPRQLGAFLTKVPLKRLEELLYKMFLHTGTVIVLPEDDLPTTMFQPVRAP
Q9WS52_9STL1/1-116              ----------------------------------------------------------------------------------------------------------MRKYSPFRNGYMEPTLGQHLPTLSFPDPGLRPQNLYTLWGDSVVCLYLYQLSPPITWPLPPHVIFCHPGQLGAFLTNVPYKRMEELLYKISLTTGALIILPEDCLPTTLFQPARAP
TAX_HTL3P/3-224                 HFPGFGQSLLYGYPVYVFGDCVQADWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVVSSALQYLIPRLPSFPTQRTTRTLKVLTPPTTATTPKVPPSFFHAVKKHTPFRNNCLELTLGEQLPAMSFPDPGLRPQNVYTIWGCSVVCLYLYQLSPPMTWPLIPHVIFCHPEQLGAFLTRVPTKRLEELLYKIFLSTGAIIILPENCFPTTLFQPTRAP
#=GC SS_cons                    XXXXXXXX---SS----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
#=GC seq_cons                   HFPGFGQSLLaGYPVYVFGDCVQuDWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVluSALQaLIPRLPSFPTQRTS+TLKVLTPPhTtTTPpIPPSFhQAMRKYSPFRNGYMEPTLGQHLPTLSFPDPGLRPQNLYTLWGuSVVChYLYQLSPPITWPLlPHVIFCHPGQLGAFLTNVPYKRlEELLYKISLTTGALIILPEDCLPTTLFQPsRAP
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