GenomeNet

Database: Pfam
Entry: TetR_C_15
LinkDB: TetR_C_15
Original site: TetR_C_15 
#=GF ID   TetR_C_15
#=GF AC   PF17918.4
#=GF DE   Tetracyclin repressor-like, C-terminal domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF03130
#=GF GA   26.80 26.80;
#=GF TC   26.80 26.80;
#=GF NC   26.70 26.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0174
#=GF RN   [1]
#=GF RM   15944459
#=GF RT   The TetR family of transcriptional repressors.
#=GF RA   Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe
#=GF RA   K, Zhang X, Gallegos MT, Brennan R, Tobes R;
#=GF RL   Microbiol Mol Biol Rev. 2005;69:326-356. 
#=GF RN   [2]
#=GF RM   27091999
#=GF RT   Structures of the nucleoid occlusion protein SlmA bound to DNA
#=GF RT   and the C-terminal domain of the cytoskeletal protein FtsZ.
#=GF RA   Schumacher MA, Zeng W;
#=GF RL   Proc Natl Acad Sci U S A. 2016;113:4988-4993.
#=GF RN   [3]
#=GF RM   7707374
#=GF RT   The complex formed between Tet repressor and tetracycline-Mg2+
#=GF RT   reveals mechanism        of antibiotic resistance.
#=GF RA   Kisker C, Hinrichs W, Tovar K, Hillen W, Saenger W;
#=GF RL   J Mol Biol. 1995;247:260-280.
#=GF DR   INTERPRO; IPR041669;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   TetR family regulators are involved in the transcriptional
#=GF CC   control of multidrug efflux pumps, pathways for the biosynthesis
#=GF CC   of antibiotics, response to osmotic stress and toxic chemicals,
#=GF CC   control of catabolic pathways, differentiation processes, and
#=GF CC   pathogenicity [1]. The TetR proteins identified in overm ultiple
#=GF CC   genera of bacteria and archaea share a common helix-turn-helix
#=GF CC   (HTH) structure in their DNA-binding domain. However, TetR
#=GF CC   proteins can work in different ways: they can bind a target
#=GF CC   operator directly to exert their effect (e.g. TetR binds Tet(A)
#=GF CC   gene to repress it in the absence of tetracycline), or they can
#=GF CC   be involved in complex regulatory cascades in which the TetR
#=GF CC   protein can either be modulated by another regulator or TetR can
#=GF CC   trigger the cellular response. This entry represents the
#=GF CC   C-terminal domain found in a number of different TetR
#=GF CC   transcription regulator proteins including SlmA proteins found
#=GF CC   in E. coli. Unlike other TetR proteins, SlmA functions not as a
#=GF CC   transcription regulator but rather as an NO (nucleoid occlusion)
#=GF CC   factor [2]. TetR regulates the expression of the
#=GF CC   membrane-associated tetracycline resistance protein, TetA, which
#=GF CC   exports the tetracycline antibiotic out of the cell before it
#=GF CC   can attach to the ribosomes and inhibit protein synthesis [3].
#=GF CC   TetR blocks transcription from the genes encoding both TetA and
#=GF CC   TetR in the absence of antibiotic. The C-terminal domain is
#=GF CC   multi-helical and is interlocked in the homodimer with the
#=GF CC   helix-turn-helix (HTH) DNA-binding domain [3].
#=GF SQ   1196
#=GS Q89MG3_BRADU/95-204       AC Q89MG3.1
#=GS A0A6L6XRE0_9ACTN/96-202   AC A0A6L6XRE0.1
#=GS A0A370B5A8_9ACTN/99-206   AC A0A370B5A8.1
#=GS A0A2G5PGR7_9MYCO/84-187   AC A0A2G5PGR7.1
#=GS A5V7D9_SPHWW/126-235      AC A5V7D9.1
#=GS A0A261GS31_9GAMM/90-191   AC A0A261GS31.1
#=GS A0A0C2QDU1_9CYAN/94-203   AC A0A0C2QDU1.1
#=GS Q1IUZ5_KORVE/97-204       AC Q1IUZ5.1
#=GS A0A1G6W9R9_9PSEU/101-205  AC A0A1G6W9R9.1
#=GS A0A1L6LKD3_9DELT/90-199   AC A0A1L6LKD3.1
#=GS V9XQB4_9NOCA/2-57         AC V9XQB4.1
#=GS A0A1H6DH98_9ACTN/89-205   AC A0A1H6DH98.1
#=GS G7CDB6_MYCT3/68-170       AC G7CDB6.1
#=GS A0A0K1PW94_9DELT/127-233  AC A0A0K1PW94.1
#=GS A0A1U9Z4R1_9RHIZ/97-204   AC A0A1U9Z4R1.1
#=GS A0A401ZMA0_9CHLR/104-211  AC A0A401ZMA0.1
#=GS A0A2T1DJ30_9CYAN/97-206   AC A0A2T1DJ30.1
#=GS A0A1H0GFL8_9FIRM/95-204   AC A0A1H0GFL8.1
#=GS A0A3P1SW31_9GAMM/109-216  AC A0A3P1SW31.1
#=GS A0A4R5C7F1_9ACTN/95-203   AC A0A4R5C7F1.1
#=GS A0A0F0HI73_LENAE/87-194   AC A0A0F0HI73.1
#=GS A0A1I5SHJ5_9BURK/94-206   AC A0A1I5SHJ5.1
#=GS A0A120MW98_9CYAN/104-213  AC A0A120MW98.1
#=GS A0A0Q8QF81_9SPHN/96-204   AC A0A0Q8QF81.1
#=GS U5RR00_9CLOT/92-201       AC U5RR00.1
#=GS A0A3N0GP93_9ACTN/98-204   AC A0A3N0GP93.1
#=GS A0A0K1QDE2_9DELT/74-183   AC A0A0K1QDE2.1
#=GS A0A495RC12_SPHMI/95-204   AC A0A495RC12.1
#=GS A0A1I0IV08_9BACL/94-203   AC A0A1I0IV08.1
#=GS A0A2Z3HPK6_9CAUL/128-234  AC A0A2Z3HPK6.1
#=GS B7JYP1_RIPO1/99-207       AC B7JYP1.1
#=GS A0A429GBU2_9ACTN/94-203   AC A0A429GBU2.1
#=GS A0A2Z5G0K5_9BACT/81-189   AC A0A2Z5G0K5.1
#=GS A0A0P4V5N8_9CYAN/102-209  AC A0A0P4V5N8.1
#=GS A0A0Q8DK32_9ACTN/76-183   AC A0A0Q8DK32.1
#=GS A0A4U1IYP1_9DELT/96-204   AC A0A4U1IYP1.1
#=GS A0A3N0VFZ9_9GAMM/102-211  AC A0A3N0VFZ9.1
#=GS A0A1N0HZQ0_9MYCO/1-96     AC A0A1N0HZQ0.1
#=GS X8BIZ2_MYCXE/84-187       AC X8BIZ2.1
#=GS A0A1H8IGX0_9ACTN/91-199   AC A0A1H8IGX0.1
#=GS A0A657AYA8_9GAMM/73-181   AC A0A657AYA8.1
#=GS A0A162JX45_9ACTN/96-202   AC A0A162JX45.1
#=GS A0A1Z4K9Z8_9CYAN/98-206   AC A0A1Z4K9Z8.1
#=GS D2B6E5_STRRD/114-221      AC D2B6E5.1
#=GS A0A1Q9S7V2_9PSEU/78-186   AC A0A1Q9S7V2.1
#=GS A0A089JVD6_9BACL/96-203   AC A0A089JVD6.1
#=GS A0A1X0Y5U9_9DELT/94-204   AC A0A1X0Y5U9.1
#=GS J3HI42_9BURK/96-199       AC J3HI42.1
#=GS A0A4R5M459_9BURK/76-183   AC A0A4R5M459.1
#=GS A0A1M7P5U3_9ACTN/101-200  AC A0A1M7P5U3.1
#=GS G2IRL5_SPHSK/105-213      AC G2IRL5.1
#=GS A0A4T0UW08_9ACTN/90-196   AC A0A4T0UW08.1
#=GS A0A6L9LVU8_9DELT/101-208  AC A0A6L9LVU8.1
#=GS A0A0N9I1Q5_9PSEU/95-203   AC A0A0N9I1Q5.1
#=GS A0A1Z2KUR8_9ACTN/101-209  AC A0A1Z2KUR8.1
#=GS A0A504F202_9RHIZ/98-199   AC A0A504F202.1
#=GS A0A3N1CWG3_9ACTN/81-192   AC A0A3N1CWG3.1
#=GS A0A014NXF4_9BURK/62-171   AC A0A014NXF4.1
#=GS K5BCY9_MYCHD/68-171       AC K5BCY9.1
#=GS A0A562CV50_9ACTN/90-199   AC A0A562CV50.1
#=GS A0A418KIZ3_9ACTN/70-177   AC A0A418KIZ3.1
#=GS A1SMH3_NOCSJ/86-195       AC A1SMH3.1
#=GS A0A1N7PND9_9GAMM/94-207   AC A0A1N7PND9.1
#=GS A0A4V3YUZ5_9ACTN/114-225  AC A0A4V3YUZ5.1
#=GS A0A3S8X078_9ACTN/94-202   AC A0A3S8X078.1
#=GS A0A0K1PKQ9_9DELT/73-180   AC A0A0K1PKQ9.1
#=GS K9UFF7_CHAP6/94-202       AC K9UFF7.1
#=GS A0A1Q9SRD0_9ACTN/107-214  AC A0A1Q9SRD0.1
#=GS E0UMZ9_GLOV7/97-205       AC E0UMZ9.1
#=GS A0A372FV56_9ACTN/75-182   AC A0A372FV56.1
#=GS A0A4R4E3G7_9BACL/69-176   AC A0A4R4E3G7.1
#=GS A0A3R7FZ18_9ACTN/134-241  AC A0A3R7FZ18.1
#=GS K0EV10_9NOCA/74-182       AC K0EV10.1
#=GS A0A550IEK1_9ACTN/94-202   AC A0A550IEK1.1
#=GS A0A1H1KD49_9RHIZ/92-197   AC A0A1H1KD49.1
#=GS D0WEH6_SLAES/119-226      AC D0WEH6.1
#=GS A0A2P7SAY0_9RHIZ/96-204   AC A0A2P7SAY0.1
#=GS A0A1I6MA24_9BACT/96-204   AC A0A1I6MA24.1
#=GS A0A1I5DNW7_9MICO/105-211  AC A0A1I5DNW7.1
#=GS A0A369WCV7_9GAMM/107-214  AC A0A369WCV7.1
#=GS A0A1I6AED7_9PSEU/93-201   AC A0A1I6AED7.1
#=GS A0A542CTC9_9PSEU/95-203   AC A0A542CTC9.1
#=GS A0A0F4JE96_9ACTN/12-102   AC A0A0F4JE96.1
#=GS A0A3S4SBK6_MYCCI/118-215  AC A0A3S4SBK6.1
#=GS A0A1V0A3W7_9ACTN/89-196   AC A0A1V0A3W7.1
#=GS A0A4P8IPT4_9BURK/97-199   AC A0A4P8IPT4.1
#=GS A0A6L5F1F0_9PSEU/105-211  AC A0A6L5F1F0.1
#=GS A0A2S5TFG5_9GAMM/101-210  AC A0A2S5TFG5.1
#=GS A0A221W528_9PSEU/94-201   AC A0A221W528.1
#=GS A0A1V0B7Q8_9PSED/90-201   AC A0A1V0B7Q8.1
#=GS A0A132PUY8_9MYCO/96-201   AC A0A132PUY8.1
#=GS A0A0T7BT00_9CYAN/97-205   AC A0A0T7BT00.1
#=GS A0A1I2J272_9ACTN/92-199   AC A0A1I2J272.1
#=GS L8LUJ0_9CYAN/94-201       AC L8LUJ0.1
#=GS A0A147H3N0_9BURK/84-191   AC A0A147H3N0.1
#=GS A0A4Y9EN49_9SPHN/110-218  AC A0A4Y9EN49.1
#=GS A0A101CMQ6_9ACTN/96-201   AC A0A101CMQ6.1
#=GS A0A132T3R9_9MYCO/84-201   AC A0A132T3R9.1
#=GS A0A0H5D4K2_9PSEU/94-197   AC A0A0H5D4K2.1
#=GS A0A556AXB6_9BURK/95-203   AC A0A556AXB6.1
#=GS A0A1X9YKX8_9SPHN/75-184   AC A0A1X9YKX8.1
#=GS A0A0N9HZS4_9PSEU/89-188   AC A0A0N9HZS4.1
#=GS A0A0J6VSI0_MYCCU/84-186   AC A0A0J6VSI0.1
#=GS I4BCP6_MYCCN/84-186       AC I4BCP6.1
#=GS B9JP64_AGRRK/84-192       AC B9JP64.1
#=GS A0A428YRL4_9ACTN/93-201   AC A0A428YRL4.1
#=GS A0A426VC27_9BURK/124-230  AC A0A426VC27.1
#=GS Q8YTB0_NOSS1/116-225      AC Q8YTB0.1
#=GS A0A0F6W5I0_9DELT/96-203   AC A0A0F6W5I0.1
#=GS A0A1C0UUU4_9CYAN/99-206   AC A0A1C0UUU4.1
#=GS A0A4Q7L6A0_9PSEU/90-194   AC A0A4Q7L6A0.1
#=GS A0A1H3NVJ8_9PSEU/95-203   AC A0A1H3NVJ8.1
#=GS B9TM16_RICCO/95-196       AC B9TM16.1
#=GS A0A4R6GM33_9BRAD/34-132   AC A0A4R6GM33.1
#=GS A0A429Z277_9RHIZ/96-204   AC A0A429Z277.1
#=GS A0A2C8F5B8_9DELT/97-207   AC A0A2C8F5B8.1
#=GS A0A399EVB2_9DEIN/95-202   AC A0A399EVB2.1
#=GS I3TPU2_TISMK/95-202       AC I3TPU2.1
#=GS A0A1Y0RJH9_9CYAN/87-194   AC A0A1Y0RJH9.1
#=GS A0A132PPA0_9MYCO/105-208  AC A0A132PPA0.1
#=GS W3RGD1_9BRAD/86-192       AC W3RGD1.1
#=GS A0A1C4M8H3_9ACTN/94-202   AC A0A1C4M8H3.1
#=GS S3AYR5_9ACTN/95-203       AC S3AYR5.1
#=GS J2LPY3_9BURK/91-199       AC J2LPY3.1
#=GS A0A1X1SXR5_9MYCO/86-187   AC A0A1X1SXR5.1
#=GS A0A1V8RV80_9RHIZ/103-210  AC A0A1V8RV80.1
#=GS D7DHK9_METV0/96-201       AC D7DHK9.1
#=GS A0A081XJ31_STRTO/96-204   AC A0A081XJ31.1
#=GS W0RUQ1_9BACT/120-228      AC W0RUQ1.1
#=GS A0A2T4V284_9DELT/124-232  AC A0A2T4V284.1
#=GS A7HS18_PARL1/94-201       AC A7HS18.1
#=GS A0A1C0BIK4_9CLOT/88-196   AC A0A1C0BIK4.1
#=GS A0A1W2AJ43_KIBAR/89-188   AC A0A1W2AJ43.1
#=GS A0A161I8B8_9BURK/115-222  AC A0A161I8B8.1
#=GS A0A3N1CYA9_9ACTN/93-201   AC A0A3N1CYA9.1
#=GS A0A4Q7XZ75_9BACT/96-199   AC A0A4Q7XZ75.1
#=GS A0A4S1EJI9_9BURK/92-201   AC A0A4S1EJI9.1
#=GS A0A3N4SDS7_9ACTN/195-303  AC A0A3N4SDS7.1
#=GS A0A4U1HEG4_9DELT/114-224  AC A0A4U1HEG4.1
#=GS K5B8H0_MYCHD/64-165       AC K5B8H0.1
#=GS A0A1H8YT91_9FIRM/90-198   AC A0A1H8YT91.1
#=GS A0A379JL43_9NOCA/74-183   AC A0A379JL43.1
#=GS A0A1Q9AW72_9RHIZ/96-204   AC A0A1Q9AW72.1
#=GS A0A2V4B0A3_9PSEU/94-202   AC A0A2V4B0A3.1
#=GS Q828S3_STRAW/96-201       AC Q828S3.1
#=GS Q6N3J7_RHOPA/94-200       AC Q6N3J7.1
#=GS W0A8L2_9SPHN/96-204       AC W0A8L2.1
#=GS A0A6L6Q0R3_9BURK/92-200   AC A0A6L6Q0R3.1
#=GS A0A4S8NM50_9ACTN/75-184   AC A0A4S8NM50.1
#=GS A0A171KNT1_9BURK/92-201   AC A0A171KNT1.1
#=GS A0A1Q9B0C4_9RHIZ/96-199   AC A0A1Q9B0C4.1
#=GS A0A4P6JXL9_9CHLR/96-203   AC A0A4P6JXL9.1
#=GS A0A4Q1JWU7_9GAMM/95-203   AC A0A4Q1JWU7.1
#=GS E4NA88_KITSK/106-212      AC E4NA88.1
#=GS W7IZ56_9PSEU/96-204       AC W7IZ56.1
#=GS S2YI05_9ACTN/95-203       AC S2YI05.1
#=GS A0A132PH11_9MYCO/91-198   AC A0A132PH11.1
#=GS A0A3A5G156_9DELT/98-206   AC A0A3A5G156.1
#=GS A0A2U1EAI0_9PSEU/93-196   AC A0A2U1EAI0.1
#=GS A0A1Q9UXA6_9PSEU/90-185   AC A0A1Q9UXA6.1
#=GS A0A3G9J4M6_9ACTN/74-179   AC A0A3G9J4M6.1
#=GS A0A100W769_9MYCO/84-187   AC A0A100W769.1
#=GS A0A6A7MDS1_9PROT/94-205   AC A0A6A7MDS1.1
#=GS W0RH74_9BACT/97-201       AC W0RH74.1
#=GS V5X597_MYCNE/84-187       AC V5X597.1
#=GS A0A1C0BQP5_9CLOT/93-202   AC A0A1C0BQP5.1
#=GS A0A1Q4RIC8_9CYAN/87-194   AC A0A1Q4RIC8.1
#=GS A0A6N7I5B5_9PSEU/87-195   AC A0A6N7I5B5.1
#=GS U5W4V5_9ACTN/94-202       AC U5W4V5.1
#=GS B7KD56_GLOC7/87-195       AC B7KD56.1
#=GS A0A1H3P5I8_9RHOB/104-207  AC A0A1H3P5I8.1
#=GS A0A0K1Q0E5_9DELT/92-200   AC A0A0K1Q0E5.1
#=GS A0A212DQZ0_9RHIZ/95-201   AC A0A212DQZ0.1
#=GS A0A4R4YUX8_9ACTN/92-199   AC A0A4R4YUX8.1
#=GS A0A1D9H6T9_9BURK/103-208  AC A0A1D9H6T9.1
#=GS A0A1I4RWI7_9PSEU/88-188   AC A0A1I4RWI7.1
#=GS B8FHP5_DESAL/97-205       AC B8FHP5.1
#=GS A0A1H5ZC10_9BACT/96-204   AC A0A1H5ZC10.1
#=GS W9BMG6_9MYCO/77-180       AC W9BMG6.1
#=GS A0A1S1QKF9_9ACTN/137-236  AC A0A1S1QKF9.1
#=GS A0A2Z4ULV2_9RHIZ/94-203   AC A0A2Z4ULV2.1
#=GS A0A0T1WJ84_9MYCO/94-202   AC A0A0T1WJ84.1
#=GS A0A0A1VJC4_9BURK/93-201   AC A0A0A1VJC4.1
#=GS G1Y2D5_9PROT/75-174       AC G1Y2D5.1
#=GS B8FLB0_DESAL/99-211       AC B8FLB0.1
#=GS A0A4R2J9X9_9PSEU/91-188   AC A0A4R2J9X9.1
#=GS A0A1A0M5V2_9MYCO/94-201   AC A0A1A0M5V2.1
#=GS A0A370BGG6_9ACTN/95-203   AC A0A370BGG6.1
#=GS A0A0Q6UZ51_9ACTN/90-195   AC A0A0Q6UZ51.1
#=GS A0A5R8YFR1_9RHIZ/106-214  AC A0A5R8YFR1.1
#=GS A0A6G8QFR6_9ACTN/1-60     AC A0A6G8QFR6.1
#=GS A0A495BN45_9BACT/104-211  AC A0A495BN45.1
#=GS A0A0K1K650_9BURK/105-213  AC A0A0K1K650.1
#=GS B8HXR3_CYAP4/96-203       AC B8HXR3.1
#=GS A0A4Q0T6D6_9BACT/96-204   AC A0A4Q0T6D6.1
#=GS A0A1A1YD08_9MYCO/84-185   AC A0A1A1YD08.1
#=GS A0A1V2THD0_9NOCA/91-196   AC A0A1V2THD0.1
#=GS A0A501X485_9GAMM/101-208  AC A0A501X485.1
#=GS A0A367ED37_9ACTN/95-203   AC A0A367ED37.1
#=GS A0A132PFP8_9MYCO/91-196   AC A0A132PFP8.1
#=GS A0A429DTP3_9ACTN/98-206   AC A0A429DTP3.1
#=GS A0A0S4NSZ7_9BURK/98-204   AC A0A0S4NSZ7.1
#=GS A0A4Y3QYY6_STRCI/97-202   AC A0A4Y3QYY6.1
#=GS A0A379JLQ1_9NOCA/72-174   AC A0A379JLQ1.1
#=GS A0A562CDS3_9ACTN/108-219  AC A0A562CDS3.1
#=GS A0A1H7PML1_9BURK/92-195   AC A0A1H7PML1.1
#=GS A0A3E0U407_9GAMM/101-212  AC A0A3E0U407.1
#=GS C1F3Y8_ACIC5/96-204       AC C1F3Y8.1
#=GS A0A562D0U9_9ACTN/86-195   AC A0A562D0U9.1
#=GS A0A3N1B1X1_9ACTN/94-202   AC A0A3N1B1X1.1
#=GS A0A1H8EUN8_9BURK/92-200   AC A0A1H8EUN8.1
#=GS A0A1J4N815_9ACTN/88-194   AC A0A1J4N815.1
#=GS A0A2T0SN57_9PSEU/95-203   AC A0A2T0SN57.1
#=GS G2NGQ9_STREK/94-202       AC G2NGQ9.1
#=GS A0A2W2E239_9ACTN/120-227  AC A0A2W2E239.1
#=GS A0A4S8N0G2_9ACTN/122-233  AC A0A4S8N0G2.1
#=GS A0A5M8SH64_9BACT/83-191   AC A0A5M8SH64.1
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