GenomeNet

Database: Pfam
Entry: TetR_C_21
LinkDB: TetR_C_21
Original site: TetR_C_21 
#=GF ID   TetR_C_21
#=GF AC   PF17926.4
#=GF DE   Tetracyclin repressor-like, C-terminal domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00748
#=GF GA   26.20 26.20;
#=GF TC   26.20 26.20;
#=GF NC   26.10 26.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0174
#=GF RN   [1]
#=GF RM   15944459
#=GF RT   The TetR family of transcriptional repressors.
#=GF RA   Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe
#=GF RA   K, Zhang X, Gallegos MT, Brennan R, Tobes R;
#=GF RL   Microbiol Mol Biol Rev. 2005;69:326-356. 
#=GF RN   [2]
#=GF RM   7707374
#=GF RT   The complex formed between Tet repressor and tetracycline-Mg2+
#=GF RT   reveals mechanism        of antibiotic resistance.
#=GF RA   Kisker C, Hinrichs W, Tovar K, Hillen W, Saenger W;
#=GF RL   J Mol Biol. 1995;247:260-280.
#=GF RN   [3]
#=GF RM   23831227
#=GF RT   SCO4008, a putative TetR transcriptional repressor from
#=GF RT   Streptomyces coelicolor A3(2), regulates transcription of
#=GF RT   sco4007 by multidrug recognition.
#=GF RA   Hayashi T, Tanaka Y, Sakai N, Okada U, Yao M, Watanabe N, Tamura
#=GF RA   T, Tanaka I;
#=GF RL   J Mol Biol. 2013;425:3289-3300.
#=GF DR   INTERPRO; IPR041467;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   TetR family regulators are involved in the transcriptional
#=GF CC   control of multidrug efflux pumps, pathways for the biosynthesis
#=GF CC   of antibiotics, response to osmotic stress and toxic chemicals,
#=GF CC   control of catabolic pathways, differentiation processes, and
#=GF CC   pathogenicity [1]. The TetR proteins identified in overm ultiple
#=GF CC   genera of bacteria and archaea share a common helix-turn-helix
#=GF CC   (HTH) structure in their DNA-binding domain. However, TetR
#=GF CC   proteins can work in different ways: they can bind a target
#=GF CC   operator directly to exert their effect (e.g. TetR binds Tet(A)
#=GF CC   gene to repress it in the absence of tetracycline), or they can
#=GF CC   be involved in complex regulatory cascades in which the TetR
#=GF CC   protein can either be modulated by another regulator or TetR can
#=GF CC   trigger the cellular response [1]. TetR regulates the expression
#=GF CC   of the membrane-associated tetracycline resistance protein,
#=GF CC   TetA, which exports the tetracycline antibiotic out of the cell
#=GF CC   before it can attach to the ribosomes and inhibit protein
#=GF CC   synthesis [2]. TetR blocks transcription from the genes encoding
#=GF CC   both TetA and TetR in the absence of antibiotic. The C-terminal
#=GF CC   domain is multi-helical and is interlocked in the homodimer with
#=GF CC   the helix-turn-helix (HTH) DNA-binding domain [2]. This entry
#=GF CC   represents the C-terminal domain present the TetR
#=GF CC   Transcriptional Repressor found in Streptomyces coelicolor A3.
#=GF CC   Family members include HTH-type transcriptional repressor
#=GF CC   sco4008, which is suggested to be a transcriptional repressor of
#=GF CC   sco4007 responsible for the multidrug resistance system in S.
#=GF CC   coelicolor A3 [3].
#=GF SQ   945
#=GS U5W4A1_9ACTN/90-199       AC U5W4A1.1
#=GS A0A2T0V5N3_9MICO/75-185   AC A0A2T0V5N3.1
#=GS W1IU32_9GAMM/79-190       AC W1IU32.1
#=GS A0A4P6FF70_9MICO/91-196   AC A0A4P6FF70.1
#=GS A0A176LDG1_9ACTN/76-186   AC A0A176LDG1.1
#=GS A0A1H6DD89_9ACTN/90-192   AC A0A1H6DD89.1
#=GS A0A370HES6_9NOCA/94-205   AC A0A370HES6.1
#=GS A0A3A4AIP2_9ACTN/76-191   AC A0A3A4AIP2.1
#=GS A0A0Q7QJC8_9ACTN/82-191   AC A0A0Q7QJC8.1
#=GS A0A4R0HDQ8_9ACTN/87-192   AC A0A4R0HDQ8.1
#=GS D3F4D5_CONWI/77-185       AC D3F4D5.1
#=GS B2HPK8_MYCMM/75-184       AC B2HPK8.1
#=GS V8D4M9_9NOCA/76-180       AC V8D4M9.1
#=GS A0A558DE78_9PSEU/77-183   AC A0A558DE78.1
#=GS A0A505D8W4_9ACTN/98-203   AC A0A505D8W4.1
#=GS A0A1I5F1F5_9ACTN/86-194   AC A0A1I5F1F5.1
#=GS A0A4Q7UP13_9PSEU/75-185   AC A0A4Q7UP13.1
#=GS A0A239D177_9ACTN/36-72    AC A0A239D177.1
#=GS A0A418KMS1_9ACTN/76-182   AC A0A418KMS1.1
#=GS A0A4P6PYW0_9ACTN/81-190   AC A0A4P6PYW0.1
#=GS A0A2M9C510_9MICO/76-180   AC A0A2M9C510.1
#=GS A0A4P7STY3_9MICC/83-186   AC A0A4P7STY3.1
#=GS A0A2N0GP78_9ACTN/76-179   AC A0A2N0GP78.1
#=GS A0A239GZN7_9ACTN/76-179   AC A0A239GZN7.1
#=GS A0A6G2UNN2_9ACTN/65-176   AC A0A6G2UNN2.1
#=GS A0A3A9YMV3_9ACTN/93-204   AC A0A3A9YMV3.1
#=GS A0A1Q8CNK6_9PSEU/101-215  AC A0A1Q8CNK6.1
#=GS H8MXQ6_CORCM/76-185       AC H8MXQ6.1
#=GS A0A6G3S0I2_9ACTN/103-200  AC A0A6G3S0I2.1
#=GS A0A2M9IL12_9ACTN/76-179   AC A0A2M9IL12.1
#=GS A0A495VXF4_9PSEU/81-190   AC A0A495VXF4.1
#=GS A0A0C1YBX3_9ACTN/76-187   AC A0A0C1YBX3.1
#=GS A0A0F0GZ22_9ACTN/76-186   AC A0A0F0GZ22.1
#=GS H0QWQ4_9ACTN/76-183       AC H0QWQ4.1
#=GS A0A3D9V8C1_9ACTN/102-214  AC A0A3D9V8C1.1
#=GS A0A1A3Q192_9MYCO/75-183   AC A0A1A3Q192.1
#=GS A0A0F0H6E3_LENAE/89-187   AC A0A0F0H6E3.1
#=GS A0A1Q5MT13_9ACTN/76-182   AC A0A1Q5MT13.1
#=GS A0A0Q9AGN3_9ACTN/68-177   AC A0A0Q9AGN3.1
#=GS A0A3L7AKV4_9MICO/79-198   AC A0A3L7AKV4.1
#=GS A0A5C8ZDB6_9ACTN/75-185   AC A0A5C8ZDB6.1
#=GS A0A3A1NZS2_9SPHN/125-245  AC A0A3A1NZS2.1
#=GS A0A561ECK9_9MICO/75-184   AC A0A561ECK9.1
#=GS A0A0N0THM9_9ACTN/81-190   AC A0A0N0THM9.1
#=GS A0A285ICF2_9ACTN/88-198   AC A0A285ICF2.1
#=GS A0A660CEU6_9PSEU/75-194   AC A0A660CEU6.1
#=GS A0A1I5XED6_9ACTN/95-204   AC A0A1I5XED6.1
#=GS A0A372G824_9ACTN/93-188   AC A0A372G824.1
#=GS A0A6G8FM80_9MICO/79-191   AC A0A6G8FM80.1
#=GS A1TCC3_MYCVP/75-184       AC A1TCC3.1
#=GS A0A2A3YLY4_9MICO/81-190   AC A0A2A3YLY4.1
#=GS A0A239DL24_9ACTN/76-180   AC A0A239DL24.1
#=GS A0A2T0SUZ8_9PSEU/76-182   AC A0A2T0SUZ8.1
#=GS A0A495IE58_9MICO/77-194   AC A0A495IE58.1
#=GS A0A6G9YSK3_9NOCA/84-192   AC A0A6G9YSK3.1
#=GS A0A2G7ER78_9ACTN/69-192   AC A0A2G7ER78.1
#=GS A0A0D4BZ54_9MICC/76-180   AC A0A0D4BZ54.1
#=GS Z9JTW3_9MICO/77-180       AC Z9JTW3.1
#=GS A0A5A7WTQ4_9MYCO/76-184   AC A0A5A7WTQ4.1
#=GS A0A223S0J5_9ACTN/76-186   AC A0A223S0J5.1
#=GS A0A495XG01_9PSEU/77-186   AC A0A495XG01.1
#=GS A0A5S4GRU3_9ACTN/155-259  AC A0A5S4GRU3.1
#=GS A0A010ZQZ0_9ACTN/81-190   AC A0A010ZQZ0.1
#=GS A0A1X7G5S1_9ACTN/78-189   AC A0A1X7G5S1.1
#=GS A0A2K8P644_STRLA/76-179   AC A0A2K8P644.1
#=GS A0A1J4N9I3_9ACTN/76-181   AC A0A1J4N9I3.1
#=GS A0A0D0KTF0_9NOCA/76-184   AC A0A0D0KTF0.1
#=GS A0A1H3H816_9PSEU/76-190   AC A0A1H3H816.1
#=GS A0A0D8I1Q7_RHOSX/77-187   AC A0A0D8I1Q7.1
#=GS A0A429BSR7_9ACTN/1-72     AC A0A429BSR7.1
#=GS H6QYL8_NOCCG/76-184       AC H6QYL8.1
#=GS A0A6N7KVB9_9ACTN/81-198   AC A0A6N7KVB9.1
#=GS A0A1E3G919_9GAMM/97-204   AC A0A1E3G919.1
#=GS A0A0Q4GTE7_9MICO/80-189   AC A0A0Q4GTE7.1
#=GS A0A6M1Y4Z1_9GAMM/87-184   AC A0A6M1Y4Z1.1
#=GS A0A327V9Y0_9ACTN/80-187   AC A0A327V9Y0.1
#=GS A0A250VRM0_STROL/88-200   AC A0A250VRM0.1
#=GS A0A4P8KPF2_9MICO/79-191   AC A0A4P8KPF2.1
#=GS Q0S726_RHOJR/76-187       AC Q0S726.1
#=GS A0A4R3I2E3_9ACTN/4-92     AC A0A4R3I2E3.1
#=GS A0A4R2IY08_9PSEU/68-195   AC A0A4R2IY08.1
#=GS A0A2T0MXB3_9ACTN/81-190   AC A0A2T0MXB3.1
#=GS A0A542J534_9BURK/79-195   AC A0A542J534.1
#=GS A0A3M8A5D5_9MICO/76-176   AC A0A3M8A5D5.1
#=GS A0A0M2HKG2_9MICO/79-188   AC A0A0M2HKG2.1
#=GS A0A1H7Y0V7_9ACTN/81-189   AC A0A1H7Y0V7.1
#=GS A0A1H2MRG6_9ACTN/108-212  AC A0A1H2MRG6.1
#=GS D2BBX1_STRRD/75-184       AC D2BBX1.1
#=GS A0A4R9E0F1_9ACTN/78-188   AC A0A4R9E0F1.1
#=GS A0A2G5IFP6_9ACTN/79-190   AC A0A2G5IFP6.1
#=GS A0A3N4SZX6_9ACTN/80-185   AC A0A3N4SZX6.1
#=GS A0A243PKL4_9SPHN/64-168   AC A0A243PKL4.1
#=GS A0A0M4QB49_9PSEU/76-178   AC A0A0M4QB49.1
#=GS D7C5T3_STRBB/81-190       AC D7C5T3.1
#=GS A0A1Q4HDS0_9MYCO/75-183   AC A0A1Q4HDS0.1
#=GS A0A4R7VUN7_9PSEU/76-182   AC A0A4R7VUN7.1
#=GS A0A2T0STG3_9PSEU/79-190   AC A0A2T0STG3.1
#=GS A0A2S2C3B2_9NOCA/76-185   AC A0A2S2C3B2.1
#=GS A0A126YV94_9MICO/76-183   AC A0A126YV94.1
#=GS A0A1X1CY12_9GAMM/75-180   AC A0A1X1CY12.1
#=GS A0A5D0NUQ2_9ACTN/95-206   AC A0A5D0NUQ2.1
#=GS A0A0K2AUQ0_STRA7/77-188   AC A0A0K2AUQ0.1
#=GS S7W3P1_9MICO/83-195       AC S7W3P1.1
#=GS A0A1B4VAN3_9GAMM/89-200   AC A0A1B4VAN3.1
#=GS A0A231H976_9NOCA/77-187   AC A0A231H976.1
#=GS H6R4A5_NOCCG/82-189       AC H6R4A5.1
#=GS A0A2G7F1F3_9ACTN/100-211  AC A0A2G7F1F3.1
#=GS A0A0B5DML1_9ACTN/76-179   AC A0A0B5DML1.1
#=GS A0A1S2Q7Z0_9ACTN/75-169   AC A0A1S2Q7Z0.1
#=GS A0A1H1UK51_9ACTN/76-185   AC A0A1H1UK51.1
#=GS A0A1H5ZWX5_9ACTN/76-183   AC A0A1H5ZWX5.1
#=GS HTHR_STRCO/77-188         AC Q9ADP7.1
#=GS HTHR_STRCO/77-188         DR PDB; 2D6Y A; 77-188;
#=GS HTHR_STRCO/77-188         DR PDB; 2D6Y B; 77-188;
#=GS A0A6M6JKC3_9PSEU/75-185   AC A0A6M6JKC3.1
#=GS A0A4V2XKZ2_9ACTN/81-190   AC A0A4V2XKZ2.1
#=GS D9V0G3_9ACTN/84-192       AC D9V0G3.1
#=GS A0A514JR17_9ACTN/77-188   AC A0A514JR17.1
#=GS A0A0S3F3V6_9SPHN/80-187   AC A0A0S3F3V6.1
#=GS A0A1I5K8Y0_9PSEU/81-190   AC A0A1I5K8Y0.1
#=GS A0A4P7SI04_9CELL/76-179   AC A0A4P7SI04.1
#=GS A0A250VSU6_STROL/81-190   AC A0A250VSU6.1
#=GS A0A5C8UP52_9MICO/76-178   AC A0A5C8UP52.1
#=GS A0A4Q7L498_9PSEU/79-192   AC A0A4Q7L498.1
#=GS W7Q1L2_9GAMM/90-184       AC W7Q1L2.1
#=GS A0A164KCB5_9NOCA/79-187   AC A0A164KCB5.1
#=GS A0A1L6JI10_9SPHN/80-184   AC A0A1L6JI10.1
#=GS A0A2T0SG82_9PSEU/75-183   AC A0A2T0SG82.1
#=GS D9X9R3_STRVT/81-190       AC D9X9R3.1
#=GS A0A1G9M8H0_9ACTN/82-193   AC A0A1G9M8H0.1
#=GS A0A1C4WPQ8_MICEC/88-200   AC A0A1C4WPQ8.1
#=GS A0A3R9XSW4_9ACTN/76-186   AC A0A3R9XSW4.1
#=GS A0A2N3ULL1_9ACTN/90-200   AC A0A2N3ULL1.1
#=GS A0A3E0G541_9PSEU/79-190   AC A0A3E0G541.1
#=GS A0A101JIR5_9ACTN/87-196   AC A0A101JIR5.1
#=GS A0A558DMC5_9PSEU/76-183   AC A0A558DMC5.1
#=GS A0A6N7YMM1_9PSEU/80-189   AC A0A6N7YMM1.1
#=GS A0A318M023_9PSEU/76-186   AC A0A318M023.1
#=GS A0A1G9W4C8_9ACTN/84-187   AC A0A1G9W4C8.1
#=GS A0A0N0SFW4_9ACTN/76-186   AC A0A0N0SFW4.1
#=GS U5VZK0_9ACTN/74-181       AC U5VZK0.1
#=GS A0A1H2W1S9_9PSEU/76-185   AC A0A1H2W1S9.1
#=GS A0A231H9R0_9NOCA/80-194   AC A0A231H9R0.1
#=GS A0A4Q7KCZ1_9PSEU/95-204   AC A0A4Q7KCZ1.1
#=GS A0A1H0M7W6_9ACTN/76-180   AC A0A1H0M7W6.1
#=GS F6EMW5_HOYSD/76-188       AC F6EMW5.1
#=GS V5XIU0_MYCNE/75-183       AC V5XIU0.1
#=GS A0A3A9Z8R4_9ACTN/106-213  AC A0A3A9Z8R4.1
#=GS A0A286DWK0_9ACTN/81-190   AC A0A286DWK0.1
#=GS A0A0B5F518_STRA4/81-190   AC A0A0B5F518.1
#=GS A0A4R3IH99_9ACTN/75-179   AC A0A4R3IH99.1
#=GS A0A0N1D460_9MICO/76-182   AC A0A0N1D460.1
#=GS A0A147EPC4_9MICO/79-183   AC A0A147EPC4.1
#=GS A0A223S1R9_9ACTN/78-186   AC A0A223S1R9.1
#=GS A0A1W2FW95_KIBAR/76-180   AC A0A1W2FW95.1
#=GS A0A0Q5E4K7_9MICO/75-184   AC A0A0Q5E4K7.1
#=GS A0A1J7C7S5_9ACTN/85-196   AC A0A1J7C7S5.1
#=GS A0A0A8EAG5_9ACTN/94-205   AC A0A0A8EAG5.1
#=GS A0A3N4SJN8_9ACTN/76-186   AC A0A3N4SJN8.1
#=GS A0A559UXN8_9ACTN/76-186   AC A0A559UXN8.1
#=GS A0A1I2JNM9_9ACTN/76-183   AC A0A1I2JNM9.1
#=GS A0A370H2E2_9NOCA/86-190   AC A0A370H2E2.1
#=GS A0A1E5PG97_9ACTN/76-187   AC A0A1E5PG97.1
#=GS A0A1X4HVI5_9ACTN/77-188   AC A0A1X4HVI5.1
#=GS A0A1Z2KXQ9_9ACTN/107-213  AC A0A1Z2KXQ9.1
#=GS A0A1V0A2H7_9ACTN/78-187   AC A0A1V0A2H7.1
#=GS A0A1R1SL13_9ACTN/78-191   AC A0A1R1SL13.1
#=GS H6MVI6_GORPV/79-183       AC H6MVI6.1
#=GS A0A3E0I6V0_9PSEU/75-177   AC A0A3E0I6V0.1
#=GS A0A1R3ULU1_9ACTN/75-182   AC A0A1R3ULU1.1
#=GS A0A372JHT1_9ACTN/79-190   AC A0A372JHT1.1
#=GS A0A0S9DKE9_9MICO/76-186   AC A0A0S9DKE9.1
#=GS D9V952_9ACTN/94-199       AC D9V952.1
#=GS A0A1W2FWK2_KIBAR/76-179   AC A0A1W2FWK2.1
#=GS A0A2V4ANB6_9PSEU/95-205   AC A0A2V4ANB6.1
#=GS A0A329R0L1_9ACTN/76-188   AC A0A329R0L1.1
#=GS E0DGC7_9CORY/79-189       AC E0DGC7.1
#=GS A0A177YC27_9NOCA/79-190   AC A0A177YC27.1
#=GS R4LES1_9ACTN/78-183       AC R4LES1.1
#=GS J1HJB3_9ACTO/79-190       AC J1HJB3.1
#=GS Q9EWE9_STRCO/99-211       AC Q9EWE9.1
#=GS Q9EWE9_STRCO/99-211       DR PDB; 2PZ9 A; 99-211;
#=GS A0A4Q1QV51_9ACTN/75-180   AC A0A4Q1QV51.1
#=GS A0A545AMP4_9ACTN/77-184   AC A0A545AMP4.1
#=GS A0A3A1TWF9_9MICO/77-190   AC A0A3A1TWF9.1
#=GS B4VGJ1_9ACTN/76-180       AC B4VGJ1.1
#=GS A0A3A9YN35_9ACTN/81-190   AC A0A3A9YN35.1
#=GS A0A2U1TAZ3_9MICO/77-177   AC A0A2U1TAZ3.1
#=GS A0A2C9A1A4_9MICO/82-194   AC A0A2C9A1A4.1
#=GS A0A2C7A5V7_9PROT/76-187   AC A0A2C7A5V7.1
#=GS A0A3A1TXT3_9MICO/76-186   AC A0A3A1TXT3.1
#=GS A0A0Q9YCT5_9COXI/83-184   AC A0A0Q9YCT5.1
#=GS A0A1I3L9W9_9BACL/77-184   AC A0A1I3L9W9.1
#=GS A0A1H6D7C4_9ACTN/89-199   AC A0A1H6D7C4.1
#=GS A0A561PZJ6_9BACL/75-182   AC A0A561PZJ6.1
#=GS A0A3N1D3S7_9ACTN/94-209   AC A0A3N1D3S7.1
#=GS A0A419HPB3_9PSEU/75-183   AC A0A419HPB3.1
#=GS A0A0F2TF95_STRR3/79-191   AC A0A0F2TF95.1
#=GS A0A561BKB9_9ACTN/75-185   AC A0A561BKB9.1
#=GS D5USU1_TSUPD/82-187       AC D5USU1.1
#=GS A0A6I3KMG6_9NOCA/78-188   AC A0A6I3KMG6.1
#=GS A0A0M4R8J8_9PSEU/79-192   AC A0A0M4R8J8.1
#=GS A0A196MGR9_9SPHN/80-184   AC A0A196MGR9.1
#=GS A0A495XLY9_9PSEU/84-194   AC A0A495XLY9.1
#=GS A0A3A4BUK3_9ACTN/76-178   AC A0A3A4BUK3.1
#=GS A0A4R4MWP3_9ACTN/88-194   AC A0A4R4MWP3.1
#=GS A0A4T2C3R2_9MICO/79-191   AC A0A4T2C3R2.1
#=GS A0A1Q9TI79_9ACTN/75-188   AC A0A1Q9TI79.1
#=GS A0A6L9SGE8_9ACTN/75-184   AC A0A6L9SGE8.1
#=GS A0A429A3K3_9ACTN/78-186   AC A0A429A3K3.1
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A0A4R6SIE8_9PSEU/91-201              ......................fpemik-------RYVRASVDKRMG.GKMLAWAG...LA.......D.....T....G.............E..D.....P..D.......D....A......Ea....kE..S...S...A.R....L...R....H.E.V....E.A....M....R....E....R.Q.K...T...........G..D..L....D.P...D....V...D......P.A..AM..MLIAMSAGN.ALAVYPQ...........iAR-..-..-.-.-..-...--.-...--.------------alfgkdgsspelvehyanela............................
A0A117RWF3_9ACTN/38-152              ............................DLPGYVGRLFDYIISHPDL.MRLAAWKQ...LE.......R.....P....L.............G..Q.....G..-.......-....-......G......K..N...I...G.S....Y...E....H.A.L....A.P....L....T....A....A.R.D...E...........G..R..I....D.T...T....F...N......P.V..DL..AVILYGLAS.AWHHIFAaqr.....dtesGTT..D..D.V.W..S...AQ.R...LT.EHREALIEVVRR.................................................
A0A563EIG9_9PSEU/90-196              .................ladvvasfvmt------------TAEQRAQ.GKLMVWAN...LA.......D.....G....T.............P..-.....-..-.......-....E......S......G..D...A...E.F....M...R....G.Q.V....A.R....L....A....E....R.Q.A...A...........G..E..L....P.P...D....I...D......P.A..FL..MLVLMAAAS.APLVLPQ...........vARQ..I..T.G.E..D...PE.S...PE.FARRYADQLA--rv...............................................
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A0A0N0XXH3_9ACTN/79-190              ............................DLGDYAGRVFDYAQQNPYP.ARLLAWEG...LL.......Y.....E....-.............G..R.....A..T.......A....E......R......K..R...V...D.H....Y...A....E.K.I....A.A....V....T....Q....A.Q.R...N...........G..T..L....T.D...E....I...G......A.G..EL..LRAVISLTA.SWVNLPQl..........aHML..T..P.K.A..T...SS.G...PP.AQRELLVTLIRR.................................................
#=GC SS_cons                         ............................GHHHHHHHHHHHHHH-CHH.HHHHHHHH...HH.......C.....T....T.............S..-.....-..T.......T....H......H......H..H...H...H.H....H...H....H.H.H....H.H....H....H....H....H.H.H...T...........T..S..S....-.T...T....S...-......H.H..HH..HHHHHHHHC.HHHH-HHH..........HHHH..H..H.H.S..C...CH.H...HH.HHHHHHHHHHHHH................................................
#=GC seq_cons                        ............................DlssaAs+laDhhhp+P-l.hRLhhWpt...LE.......t.....s..................s..s.....s..........t....t......s......t..p...t...p.t....h...t....p.K.l....s.s....l....t....p....A.Q.t...t...........G..t..l....s.s...s....h...s......s.s..cL..lhhlhulut.sassssp............hhh..h..s.s.t..s...st.t...ht.ppRthlhpsst..................................................
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