#=GF ID   Tis1_ImmP
#=GF AC   PF24154.2
#=GF DE   Tis1 immunity protein
#=GF AU   Andreeva A;0000-0002-0450-0091
#=GF SE   Manual
#=GF GA   27.00 27.00;
#=GF TC   29.40 49.30;
#=GF NC   25.60 23.20;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 90746521 --cpu 8 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   31695193
#=GF RT   An interbacterial toxin inhibits target cell growth by
#=GF RT   synthesizing (p)ppApp.
#=GF RA   Ahmad S, Wang B, Walker MD, Tran HR, Stogios PJ, Savchenko A,
#=GF RA   Grant RA, McArthur AG, Laub MT, Whitney JC;
#=GF RL   Nature. 2019;575:674-678.
#=GF DR   INTERPRO; IPR056206;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Tas1 is a type VI secretion effector in the pathogen Pseudomonas
#=GF CC   aeruginosa that synthesizes (p)ppApp. Its cognate immunity
#=GF CC   protein Tis1 is represented by this entry. Binding of the
#=GF CC   immunity protein probably neutralises Tas1-mediated toxicity by
#=GF CC   inducing structural rearrangement in the acceptor nucleotide
#=GF CC   binding site of the enzyme [1].
#=GF SQ   14
#=GS A0A0D6SLL0_9PSED/1-51     AC A0A0D6SLL0.1
#=GS Q8XTX7_RALN1/1-64         AC Q8XTX7.1
#=GS A0A1X7FA05_TRICW/1-73     AC A0A1X7FA05.1
#=GS A0A1I3VMK7_9BURK/1-73     AC A0A1I3VMK7.1
#=GS A0A3S0PZM1_9GAMM/1-74     AC A0A3S0PZM1.1
#=GS Q21GQ9_SACD2/1-74         AC Q21GQ9.1
#=GS A0A5P9EUU3_9GAMM/361-434  AC A0A5P9EUU3.1
#=GS A0A369UH08_9GAMM/1-74     AC A0A369UH08.1
#=GS A0A2U9T2Y0_9GAMM/1-74     AC A0A2U9T2Y0.1
#=GS A0A1W1Y1K9_9NEIS/1-74     AC A0A1W1Y1K9.1
#=GS A0A1M5XDJ4_9VIBR/1-74     AC A0A1M5XDJ4.1
#=GS A0A1I6M2A7_9SPHN/8-77     AC A0A1I6M2A7.1
#=GS A0A523Q1X4_9BURK/1-74     AC A0A523Q1X4.1
#=GS A0A245ZJA2_9SPHN/8-77     AC A0A245ZJA2.1
A0A0D6SLL0_9PSED/1-51                .........-----------------------MFRWDHRQGQVFVKFYGQSESVEPVPQDSRLYNEALRFGEEITREAYEAGK.
Q8XTX7_RALN1/1-64                    .......mr-----------GDTYIDYPFEEVMFRWCHVEKKAYRKFYCERESG-PIPHDNNLYNEALRSGDEITREAYIAGK.
A0A1X7FA05_TRICW/1-73                .........MGINKGERFGREDLYVDYPFEDVMFRWDYLEQKVYRKFYGEKETG-PIPHDNRLYNDALLYGDEITREVYAAGK.
A0A1I3VMK7_9BURK/1-73                .........MGIKKDERFGREDIYVDYPFEEVMFRWDHKDRKVYRKFYDKAESG-PVPPDNNLYNEALRFGDEIQRDAYIAGK.
A0A3S0PZM1_9GAMM/1-74                .........MGVSKGPEFARRDIYIDYAYLRVMFRWDHVAGKIYVRHYGHVETATPVPHDNGLFTEATLYGLEISQAEYLAGK.
Q21GQ9_SACD2/1-74                    .........MAIKTGEYLNTKDVYIDYPFEEVMFRRMKKNGAIYRKFYGEKESTEVIHYQNKLYNEALLSGDEITQEEYEIGE.
A0A5P9EUU3_9GAMM/361-434             .........MSIKTGEYLNLKHVYIDYSFESVMFRRDKETKNIYRKFYGEKEHPAPIPHTNRLFNDALLYGQEITKEEYLKGE.
A0A369UH08_9GAMM/1-74                .........MPVSKGEHFAQRDIYIDYSFEEVMFRCDHVTGSIFRRFYGEGESAKPVPHDNHLFNHALLYGDEITSEQYEQGK.
A0A2U9T2Y0_9GAMM/1-74                .........MAPGKGEHFATRDIYIDYDFEEVTYRWDHRLRRIYVRFYGEIESPGAVPHDNRPFTDALRFGREITRGDYERG-f
A0A1W1Y1K9_9NEIS/1-74                .........MAVEKGTNFVGRDVYIDYSYMKVMFRWDHVAGCIFVRPYGKAELPTPVPHDNKIFNDATLYGFEISSEEYLKGK.
A0A1M5XDJ4_9VIBR/1-74                .........MGISKSRLSSIEDIFIDYPFEDVMYRWDSKNKKVHVKFYGKEESKNEVSHDNRLFNDALLFGNEITKDEYAAGK.
A0A1I6M2A7_9SPHN/8-77                .gvpseafr---------QAEDVCIIYSFEDVAFRWDHATGRVFRRFRDTGRES-ETDSANRLFGDAQTGGRLATREEYD---a
A0A523Q1X4_9BURK/1-74                .mknphdaf--------NAGRDVYIDYPYESVMFRWEHLTQRVYKKFYGQVESANPVPHDNRLYNDAILCGDEIDAAAYLQGK.
A0A245ZJA2_9SPHN/8-77                gvpseafre----------GHDVYVIYSFEDVASHWEHASERVFRRFKGTGRESET-VHSNRLFADAQIGGRLATREEYE---h
#=GC seq_cons                        .........Ms.tps...stcDlYIDYsFE-VMFRWDHhst+la++FYGctEostPlPHDN+LaN-ALlaGcEIT+EpY.tGK.
//