GenomeNet

Database: Pfam
Entry: Tk-SP_N-pro
LinkDB: Tk-SP_N-pro
Original site: Tk-SP_N-pro 
#=GF ID   Tk-SP_N-pro
#=GF AC   PF18237.4
#=GF DE   Tk-SP N-propeptide domain
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF04991
#=GF GA   26.50 26.50;
#=GF TC   27.00 27.30;
#=GF NC   26.30 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0570
#=GF RN   [1]
#=GF RM   20595040
#=GF RT   Crystal structure of a subtilisin homologue, Tk-SP, from
#=GF RT   Thermococcus kodakaraensis: requirement of a C-terminal
#=GF RT   beta-jelly roll domain for hyperstability.
#=GF RA   Foophow T, Tanaka S, Angkawidjaja C, Koga Y, Takano K, Kanaya S;
#=GF RL   J Mol Biol. 2010;400:865-877.
#=GF DR   INTERPRO; IPR041326;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the N-propeptide domain found in Tk-SP, a
#=GF CC   subtilisin-like serine protease from Thermococcus kodakaraensis.
#=GF CC   The beta sheet of this domain packs tightly to the two nearly
#=GF CC   parallel alpha helices 2 and 3 located at the surface of the
#=GF CC   subtilisin domain. Gln105 and Asp107 of the N-propeptide domain
#=GF CC   also bind to the N-termini of these two alpha-helices to form
#=GF CC   helix caps [1].
#=GF SQ   21
#=GS A0A1I3U5D7_9BACL/47-113  AC A0A1I3U5D7.1
#=GS A0A3Q9HPY2_9FIRM/41-105  AC A0A3Q9HPY2.1
#=GS A0A4R3L6S8_9BACL/49-115  AC A0A4R3L6S8.1
#=GS A0A4R3NCZ8_9BACI/52-120  AC A0A4R3NCZ8.1
#=GS A0A235FFX0_9BACI/33-101  AC A0A235FFX0.1
#=GS A0A096BK00_9CLOT/54-121  AC A0A096BK00.1
#=GS S0FME8_RUMCE/47-114      AC S0FME8.1
#=GS A0A1M6R337_9CLOT/54-121  AC A0A1M6R337.1
#=GS A0A1T5M656_9CLOT/54-119  AC A0A1T5M656.1
#=GS R7RSJ3_9CLOT/2-65        AC R7RSJ3.1
#=GS A0A140KZU6_9CLOT/54-121  AC A0A140KZU6.1
#=GS Q8RBJ2_CALS4/57-124      AC Q8RBJ2.1
#=GS A0A0A5I207_9BACI/56-128  AC A0A0A5I207.1
#=GS TKSP_THEKO/37-103        AC Q5JIZ5.1
#=GS TKSP_THEKO/37-103        DR PDB; 3AFG A; 14-80;
#=GS TKSP_THEKO/37-103        DR PDB; 3AFG B; 14-80;
#=GS R1AR17_9CLOT/54-118      AC R1AR17.1
#=GS A0A4E0Q582_9EURY/22-73   AC A0A4E0Q582.1
#=GS L0L2B9_METHD/27-74       AC L0L2B9.1
#=GS A0A1B1Z1J5_9BACI/27-95   AC A0A1B1Z1J5.1
#=GS A0A1C0A7K6_9FIRM/33-97   AC A0A1C0A7K6.1
#=GS Q8U0C9_PYRFU/37-103      AC Q8U0C9.1
#=GS A0A1H8EAR0_9BACL/46-114  AC A0A1H8EAR0.1
A0A1I3U5D7_9BACL/47-113             .....kgt----KYMSNLKNKMDQ...ASDSENIPVIVTFK..T...KDQSSNLK.KAKSAVPNFSPKHVYKNIPAMSAKLTKSQ...
A0A3Q9HPY2_9FIRM/41-105             ........KDNDKIFDDLALKLKD...ASDSDEFKVIAVFN..E...SYNLQ---.GIKNAIGHFATSYEYININAFAATLNKGQ...
A0A4R3L6S8_9BACL/49-115             .....qgs----KLLSNLQNKISK...VNHSEKLPVIITFK..N...LQQTSNLQ.ASKAKVPSLKAKHLYKNIPAIATELTKS-e..
A0A4R3NCZ8_9BACI/52-120             ........KNGNKFFDNLEQKLDQ...AKNDEKLPVIIQFD..T..sKVNSNAAN.ALQKRIGKFDVKYKYEIIDGVAATLTKKQ...
A0A235FFX0_9BACI/33-101             .......s-NSNKMLDNLEQKIKG...LKNEEKVPVIIQFN..E...EFAGGKAYeKLAQKLGAFKKNFDYKVFNGMAATMTVKQ...
A0A096BK00_9CLOT/54-121             .......s-NKDKLFENLSKKMDK...VTDNEEIPVIVVFK..E...KLDSKRKI.FVNKLIGNYKIKHEYKNIPAIAMKLKKDQ...
S0FME8_RUMCE/47-114                 ......sp--NSKLFVNLEKKINE...AKDSDEVPVTVVFN..K...KLTDDEFA.SIEKLLGNPEIKHKFEIIPGAALNLTKNQ...
A0A1M6R337_9CLOT/54-121             ........KDKDKLFENLSEKMNK...AKDDEEISVIVVFE..E...KMNKVRNN.DMKMLLGSYKIKHEYKNIPAVAMKLNKGQ...
A0A1T5M656_9CLOT/54-119             ........KNKDKIFESLSKEMKK...TE--DELPVIIVFN..E...KSDKVKSN.NIKSLLGKYKVKHEYKNIPAAAMKLNKE-e..
R7RSJ3_9CLOT/2-65                   fwflnkki----------DKKLKEymnINSKRKIPVIVTYK..N...NLKSSKNS.IVYN--GG-KIKYEYKIINAIACEL----sp.
A0A140KZU6_9CLOT/54-121             ........ENKDKLFENLSKKMDK...ANDDEEISVIVVFK..D...KLDTEKKG.KVKEVLGEYMAKHEYENIPAMAMKLKKGQ...
Q8RBJ2_CALS4/57-124                 .......s-NKNKIFDDLEQRLLN...KPDSEEFPVIITFN..K...PVSDADIF.TIAKNIGKFNIKHRYKIIPSIAANLTKSQ...
A0A0A5I207_9BACI/56-128             ........KDQNKLYDNLEQKLKE...MQQNEKLPVIIQFDtsNmpgKSSKALDK.KLKNQVGKYSTKHTYSVVKGVAATLNKKQ...
TKSP_THEKO/37-103                   ........KNYGLLTPGLFKKVQR...MSWDQEVSTIIMFD..N...QADKEKAV.EILDFLGA-KIKYNYHIIPALAVKIKVKD...
#=GR TKSP_THEKO/37-103        SS    ........--BTTB-HHHHHHHHT...S-TT-EEEEEEEES..S...HHHHHHHH.HHHHHCT--EEEEE-SSSSEEEEEEEHHH...
R1AR17_9CLOT/54-118                 ........KNNNKIFENLEKKLEK...ASDKENLPVIVVFK..N...KPDKN---.NLKNILGNYKTKHEYKNIPAIAMELNKGQ...
A0A4E0Q582_9EURY/22-73              ....tasa---------------K...TNENEKVPVLITFK..G...TTDAD---.LVKAHGGN--VKYEYTIIPSIAAELPQ--ka.
L0L2B9_METHD/27-74                  ....aaqe----------------...--KQEKVPVLINFK..E...KTDTE---.LVKAHGGN--VKHEYTIIPAVAAEL----ppq
A0A1B1Z1J5_9BACI/27-95              .......l-NKNKLFDNLESKLQQ...LTDEEKVPVIIQFN..E...EFAGGKAFeKLASKVGVFKKSFEYKVINGMAATMTKKQ...
A0A1C0A7K6_9FIRM/33-97              ........KNGNKIFEDLEEKLAE...IKGNYKLDIIVVFN..K...NFTKK---.AIEAKIGAFDLKYNYKNINAFAGKLNKGQ...
Q8U0C9_PYRFU/37-103                 ........KNYGLLTPGLFRKIQK...LNPNEEISTVIVFE..N...HREKEIAV.RVLELMGA-KVRYVYHIIPAIAADLKVRD...
A0A1H8EAR0_9BACL/46-114             ....kvkg---SKLLSNLHERLSK...ASSSEKLPVLISFQ..S...LNQQANLT.KAKAMLQPFTPQHVYKNLPLMSAKLTKQQ...
#=GC SS_cons                        ........--BTTB-HHHHHHHHT...S-TT-EEEEEEEES..S...HHHHHHHH.HHHHHCT--EEEEE-SSSSEEEEEEEHHH...
#=GC seq_cons                       .........stsKlhpsLppKlpc...hsssEclPVIlsFc..p...chspsp...plcshlGsachKacY+sIPAhAscLsKpQ...
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